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Conserved domains on  [gi|1906101402|ref|WP_188877265|]
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helix-turn-helix domain-containing protein [Halarchaeum grantii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
1-128 4.03e-47

Predicted transcriptional regulator [Transcription];


:

Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 148.19  E-value: 4.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402   1 MADSMSEMLRADMECEGLLECFHDLKALDREIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNYE 80
Cdd:COG3355     1 MSDSIEMLVRLEPDLEDVLECVYGLSETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1906101402  81 QGGYYHVYEPRDGEEIAQELQRTLNDWYAKMGTLIGEFEQKYGETPER 128
Cdd:COG3355    81 GGGYPYVYYAIDPEELKEKLVDDLDEWYEKVGELIEEFEEEKADPLAI 128
 
Name Accession Description Interval E-value
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
1-128 4.03e-47

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 148.19  E-value: 4.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402   1 MADSMSEMLRADMECEGLLECFHDLKALDREIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNYE 80
Cdd:COG3355     1 MSDSIEMLVRLEPDLEDVLECVYGLSETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1906101402  81 QGGYYHVYEPRDGEEIAQELQRTLNDWYAKMGTLIGEFEQKYGETPER 128
Cdd:COG3355    81 GGGYPYVYYAIDPEELKEKLVDDLDEWYEKVGELIEEFEEEKADPLAI 128
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 19-92 1.76e-11

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 55.60  E-value: 1.76e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402  19 LECFhDLKALDREIFEVLCERGESlTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNyeqggyYHVYEPRD 92
Cdd:pfam01978   1 LQKL-GLSEYEAKVYLALLKLGPA-TADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGR------PKKYRAVD 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 25-105 4.16e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 47.29  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  25 LKALD----REIFEVLCERGesLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVnyeqgGYYHVYEPRDGEEIAQEL 100
Cdd:cd00090     1 LKALSdptrLRILRLLLEGP--LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE-----GRRVYYSLTDAERLLALL 73


                  ....*
gi 1906101402 101 QRTLN 105
Cdd:cd00090    74 ESLLE 78
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
26-87 2.29e-05

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 40.26  E-value: 2.29e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402   26 KALDR--EIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEqvnyEQGGYYHV 87
Cdd:smart00346   2 QSLERglAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQD----GQNGRYRL 61
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 31-75 9.18e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 34.64  E-value: 9.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1906101402  31 EIFEVLCERGEsLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:TIGR01884 147 KILEVLKATGE-KSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK 190
 
Name Accession Description Interval E-value
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
1-128 4.03e-47

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 148.19  E-value: 4.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402   1 MADSMSEMLRADMECEGLLECFHDLKALDREIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNYE 80
Cdd:COG3355     1 MSDSIEMLVRLEPDLEDVLECVYGLSETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1906101402  81 QGGYYHVYEPRDGEEIAQELQRTLNDWYAKMGTLIGEFEQKYGETPER 128
Cdd:COG3355    81 GGGYPYVYYAIDPEELKEKLVDDLDEWYEKVGELIEEFEEEKADPLAI 128
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 19-92 1.76e-11

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 55.60  E-value: 1.76e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402  19 LECFhDLKALDREIFEVLCERGESlTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNyeqggyYHVYEPRD 92
Cdd:pfam01978   1 LQKL-GLSEYEAKVYLALLKLGPA-TADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGR------PKKYRAVD 66
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 13-96 7.75e-09

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 49.14  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  13 MECEGLLECFHDLKALDREIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVnyeqGGYYHVYEPRD 92
Cdd:COG2512     1 MLVVAALLLYPELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERV----GRENVVELPED 76


                  ....
gi 1906101402  93 GEEI 96
Cdd:COG2512    77 EPEA 80
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 25-105 4.16e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 47.29  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  25 LKALD----REIFEVLCERGesLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVnyeqgGYYHVYEPRDGEEIAQEL 100
Cdd:cd00090     1 LKALSdptrLRILRLLLEGP--LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE-----GRRVYYSLTDAERLLALL 73


                  ....*
gi 1906101402 101 QRTLN 105
Cdd:cd00090    74 ESLLE 78
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
26-87 4.40e-08

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 49.82  E-value: 4.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402  26 KALDR--EIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEqvnyEQGGYYHV 87
Cdd:COG1414     6 QSLERalAILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERD----PEGGRYRL 65
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
24-102 3.85e-07

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 45.92  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  24 DLKALDREIFEVLcERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE--QVNYEQGGYY-----HVY-EPRDGEE 95
Cdd:COG1522     2 ELDEIDRRILRLL-QEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYgaVVDPEKLGLGvtafvEVKvPPHRLDE 80


                  ....*..
gi 1906101402  96 IAQELQR 102
Cdd:COG1522    81 FAEALAA 87
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
30-92 4.60e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 44.95  E-value: 4.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1906101402  30 REIFEVLCERGesLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNYEQGGYYHVYEPRD 92
Cdd:COG4189    22 LRILRLLAEEP--LNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYLRVD 82
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
29-95 4.18e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 43.33  E-value: 4.18e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1906101402  29 DREIFEVLCERGeSLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKeqvnyEQGGYYHVYEPRDGEE 95
Cdd:COG3398    99 PRRILLYLLENP-GATNKELAEELGISRSTVSWHLKRLEEDGLVER-----ERDGRNVRYYLNPPER 159
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
30-94 5.32e-06

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 43.02  E-value: 5.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  30 REIFEVLCERGESLTVDEIADEVGRE-----RSTAYRSVQRLLQAGFIRKeqVNYEQGGYYhvYEPRDGE 94
Cdd:COG0735    23 LAILELLLESDRHLSAEEIYEALRKKgpsisLATVYRTLDLLVEAGLVHR--IEFGGGKAR--YELNEGD 88
HTH_IclR pfam09339
IclR helix-turn-helix domain;
27-75 1.15e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 40.08  E-value: 1.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1906101402  27 ALDR--EIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:pfam09339   1 SLDRalAILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYVEQD 51
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
26-87 2.29e-05

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 40.26  E-value: 2.29e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402   26 KALDR--EIFEVLCERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEqvnyEQGGYYHV 87
Cdd:smart00346   2 QSLERglAVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQD----GQNGRYRL 61
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
28-72 5.61e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.18  E-value: 5.61e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1906101402  28 LDREIFEVLCERGeSLTVDEIADEVGRERSTAYRSVQRLLQAGFI 72
Cdd:pfam13412   2 TDRKILNLLQENP-RISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-75 8.62e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.95  E-value: 8.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1906101402  23 HDLKALDREIFEVLcERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:pfam12802   1 LGLTPAQFRVLLAL-ARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 30-94 8.93e-05

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 39.10  E-value: 8.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  30 REIFEVLCERGESLTVDEIADEVGRE-----RSTAYRSVQRLLQAGFIRKeqVNYEQGGYYhvYEPRDGE 94
Cdd:cd07153     4 LAILEVLLESDGHLTAEEIYERLRKKgpsisLATVYRTLELLEEAGLVRE--IELGDGKAR--YELNTDE 69
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 25-102 1.29e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 38.65  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402   25 LKALDREIFEVLCERGEsLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQ--VNYEQGGYYHV------YEPRDG-EE 95
Cdd:smart00344   1 LDEIDRKILEELQKDAR-ISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTavLNPKKLGLSVTafvgvtLENPDKlEE 79


                   ....*..
gi 1906101402   96 IAQELQR 102
Cdd:smart00344  80 FLEKLEK 86
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 24-75 1.36e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 39.90  E-value: 1.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1906101402  24 DLKALDREIFEVLC----ERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:COG1974     3 KLTKRQREILDFIKeyirERGYPPSQREIAEALGLSSSAVHRHLKALEKKGYLRRD 58
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 25-75 2.05e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 37.13  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1906101402  25 LKALD----REIFEVLCERgESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:pfam12840   4 AEALAdptrLRILRALVGD-EPLTASELARRLDISRNTLSYHLRKLEEAGLVEVV 57
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 28-101 3.47e-04

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 37.58  E-value: 3.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1906101402  28 LDREIFEVLCERGeSLTVDEIADEVGRERSTAYRSVQ----RLLQAGFirkeqVNYEQGGYYHVYEPRDGEEIAQELQ 101
Cdd:pfam03965   4 AEAEVMEILWALG-PATVKEVVEELPEPKDWAYSTVKtlltRLVKKGL-----LSREKDGRAFIYSPLVSREEYKAGQ 75
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-111 4.39e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 4.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402   23 HDLKALD--REIFEVLC--ERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQvNYEQGGYYHVYEPRDGEEIAQ 98
Cdd:smart00347   1 EELKPLGltPTQFLVLRilYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP-SPEDRRSVLVSLTEEGRELIE 79

                           90
                   ....*....|...
gi 1906101402   99 ELQRTLNDWYAKM 111
Cdd:smart00347  80 QLLEARSETLAEL 92
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
25-106 4.65e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.79  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906101402  25 LKAL-D---REIFEVLCERGesLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVnyeqgGYYHVYEPRDgeEIAQEL 100
Cdd:COG0640    14 FKALaDptrLRILRLLAEGE--LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRRE-----GRWVYYRLAD--EALAEL 84


                  ....*.
gi 1906101402 101 QRTLND 106
Cdd:COG0640    85 LEWLLE 90
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
31-94 8.87e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 8.87e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906101402   31 EIFEVLCERGesLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVnyeqgGYYHVYEPRDGE 94
Cdd:smart00418   1 KILKLLAEGE--LCVCELAEILGLSQSTVSHHLKKLREAGLVESRRE-----GKRVYYSLTDEK 57
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-76 1.48e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.83  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1906101402  33 FEVL--CERGESLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQ 76
Cdd:pfam01047   6 FHILriLYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
30-80 9.02e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 34.87  E-value: 9.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1906101402  30 REIFEVLCERgeSLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKEQVNYE 80
Cdd:COG4742    19 KNILLLLAEG--PKTRSELAESLDVSRSTILRQLKELEERGLIERDDGEYE 67
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 31-75 9.18e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 34.64  E-value: 9.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1906101402  31 EIFEVLCERGEsLTVDEIADEVGRERSTAYRSVQRLLQAGFIRKE 75
Cdd:TIGR01884 147 KILEVLKATGE-KSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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