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Conserved domains on  [gi|1906108909|ref|WP_188884566|]
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helix-turn-helix transcriptional regulator [Halarchaeum grantii]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 11-79 1.01e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member pfam03551:

Pssm-ID: 481197  Cd Length: 74  Bit Score: 54.95  E-value: 1.01e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906108909 11 LLYVIGgLNEPNGLEVKDELEGYY--ETEIHHGRLYPNLDTLVDKGLVEKGEID----KRTNFYALTRRGRRELE 79
Cdd:pfam03551  1 VLAVLG-EQPRYGYEIIKELEELSggFWRPSEGTLYPILKRLEKEGLVESEWVDsgggPPRKYYRLTDAGRRELA 74
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 11-79 1.01e-11

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 54.95  E-value: 1.01e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906108909 11 LLYVIGgLNEPNGLEVKDELEGYY--ETEIHHGRLYPNLDTLVDKGLVEKGEID----KRTNFYALTRRGRRELE 79
Cdd:pfam03551  1 VLAVLG-EQPRYGYEIIKELEELSggFWRPSEGTLYPILKRLEKEGLVESEWVDsgggPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
23-90 9.51e-11

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 53.40  E-value: 9.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906108909  23 GLEVKDELEGYYE--TEIHHGRLYPNLDTLVDKGLVEKGEID----KRTNFYALTRRGRRELEARREWENQYVE 90
Cdd:COG1695    25 GYEIIKELEERSGgfWKVSEGTLYPALKRLEKEGLVESEWEEseggPRRKYYRLTEAGREELAEWLEEWEKLAE 98
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 11-79 1.01e-11

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 54.95  E-value: 1.01e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906108909 11 LLYVIGgLNEPNGLEVKDELEGYY--ETEIHHGRLYPNLDTLVDKGLVEKGEID----KRTNFYALTRRGRRELE 79
Cdd:pfam03551  1 VLAVLG-EQPRYGYEIIKELEELSggFWRPSEGTLYPILKRLEKEGLVESEWVDsgggPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
23-90 9.51e-11

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 53.40  E-value: 9.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1906108909  23 GLEVKDELEGYYE--TEIHHGRLYPNLDTLVDKGLVEKGEID----KRTNFYALTRRGRRELEARREWENQYVE 90
Cdd:COG1695    25 GYEIIKELEERSGgfWKVSEGTLYPALKRLEKEGLVESEWEEseggPRRKYYRLTEAGREELAEWLEEWEKLAE 98
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-83 1.89e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.95  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906108909   2 HDLTGFQRDLLYVIGGLNEPNGLEVKDELEgyyeteIHHGRLYPNLDTLVDKGLVE--KGEIDKRTNFYALTRRGRRELE 79
Cdd:COG1846    34 LGLTPAQFRVLAALAEAGGLTQSELAERLG------LTKSTVSRLLDRLEEKGLVErePDPEDRRAVLVRLTEKGRALLE 107


                  ....
gi 1906108909  80 ARRE 83
Cdd:COG1846   108 EARP 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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