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Conserved domains on  [gi|1906446634|ref|WP_189213527|]
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gamma-glutamyltransferase [Actinokineospora fastidiosa]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10001375)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

CATH:  3.60.20.40
Gene Ontology:  GO:0016787
SCOP:  4000420

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
39-577 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 440174  Cd Length: 507  Bit Score: 564.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  39 AVVSDTAEATEAGLRVLRaggtaadaavavaatLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFVD 118
Cdd:COG0405     1 MVATAHPLASQAGLEILRaggnavdaavaaaaaLAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 119 PATGraypfwDAVTSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAE 198
Cdd:COG0405    81 AGDE------IPVRGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDPGAAA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 199 LFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHPPlardatidppaGLMTLSDLRHYRTIDRK 278
Cdd:COG0405   155 IFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAG-----------GLLTLEDLAAYRAEWRE 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 279 PTHVNYRGYDVYGMAPSSSgGMTVGMALNTLEPFDLGSLDRS--QALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLS 356
Cdd:COG0405   224 PLSGTYRGYTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDsaEYVHLLAEAMKLAFADRDRYLGDPDFVDVPVEGLLS 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 357 ESYGKSRSCLIDPIRVLPAPAapgnpygdhecvpppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGR 436
Cdd:COG0405   303 PAYAAERAALIDPDRATPSPR---------------PGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 437 GFLLNNELTDFNFTPTqgdapDPNLAAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDA 516
Cdd:COG0405   368 GFLLNNRGDDFSLDPG-----HPNALAPGKRPRSTMSPTIVLKDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEA 442
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906446634 517 VAAPRASQRNTPTTV-AEPAF-IATAGDLTALGHVFTAQPT-IGAAAALEFTPTQT-QAVGEPTR 577
Cdd:COG0405   443 VDAPRWHHQGLPDTLeLEPRFpPAVIAALRARGHKVEVVPDwSGGAQAILRDPDGVlEGAADPRR 507
 
Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
39-577 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 564.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  39 AVVSDTAEATEAGLRVLRaggtaadaavavaatLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFVD 118
Cdd:COG0405     1 MVATAHPLASQAGLEILRaggnavdaavaaaaaLAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 119 PATGraypfwDAVTSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAE 198
Cdd:COG0405    81 AGDE------IPVRGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDPGAAA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 199 LFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHPPlardatidppaGLMTLSDLRHYRTIDRK 278
Cdd:COG0405   155 IFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAG-----------GLLTLEDLAAYRAEWRE 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 279 PTHVNYRGYDVYGMAPSSSgGMTVGMALNTLEPFDLGSLDRS--QALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLS 356
Cdd:COG0405   224 PLSGTYRGYTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDsaEYVHLLAEAMKLAFADRDRYLGDPDFVDVPVEGLLS 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 357 ESYGKSRSCLIDPIRVLPAPAapgnpygdhecvpppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGR 436
Cdd:COG0405   303 PAYAAERAALIDPDRATPSPR---------------PGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 437 GFLLNNELTDFNFTPTqgdapDPNLAAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDA 516
Cdd:COG0405   368 GFLLNNRGDDFSLDPG-----HPNALAPGKRPRSTMSPTIVLKDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEA 442
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906446634 517 VAAPRASQRNTPTTV-AEPAF-IATAGDLTALGHVFTAQPT-IGAAAALEFTPTQT-QAVGEPTR 577
Cdd:COG0405   443 VDAPRWHHQGLPDTLeLEPRFpPAVIAALRARGHKVEVVPDwSGGAQAILRDPDGVlEGAADPRR 507
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
72-579 3.75e-165

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 479.78  E-value: 3.75e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  72 LGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFvdpatGRAYPFWDAVTSGLSVGTPGMLATWERALR 151
Cdd:pfam01019  21 LGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMF-----DGKGDSKLSLTGGLAVGVPGEVAGLAEAHK 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 152 KWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAELFLPGGKVPAVGTIMRNPDLAATYREIARHGTR 231
Cdd:pfam01019  96 RYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQPALAKTLELIAEEGPD 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 232 TFYGGAIGRDVVDAVQHPPlardatidppaGLMTLSDLRHYRTIDRKPTHVNYRGYDVYgMAPSSSGGMTVGMALNTLEP 311
Cdd:pfam01019 176 AFYRGELAQQLVADLQANG-----------GIITAEDLANYRVKIREPLSADYGGYTVY-SPPPSSGGIALLQILNILEG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 312 FDLGS-LDRSQALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLSESYGKSRSCLIDPIRVLPAPAApgnpygdhecvP 390
Cdd:pfam01019 244 FDLSSlLNSAEYLHLLIEAMKLAYADRTRYLGDPDFVPVPVENLLSPEYAKERAKLINPNAAFPSSYA-----------P 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 391 PPPGTAsseneahtnHFVVSDARGNIVSYTNTIEQVGGSGIVVPGRGFLLNNELTDFNFTPTQGDAPDPNLA---APGKR 467
Cdd:pfam01019 313 EDGGTT---------HFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPGNAFGLDPSPAnaiAPGKR 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 468 PRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDAVAAPRASQRNTPTTVAEPAF-IATAGDLTAL 546
Cdd:pfam01019 384 PLSSMAPTIVLDDGKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQLPDVLEVEPGFpEEVLAELEAR 463
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1906446634 547 GHVFTAQPTIGA--AAALEFTPTQT-QAVGEPTRRG 579
Cdd:pfam01019 464 GHKVKVVEDSSSvgAIQIVRRTGGVlYAASDPRRDG 499
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
38-575 2.84e-129

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 388.74  E-value: 2.84e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  38 GAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFV 117
Cdd:TIGR00066   1 GMVASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 118 DpATGRAYPFWDAvTSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRF-RQFSST 196
Cdd:TIGR00066  81 D-KSGNPLPGKSL-TGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLlTTKEDS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 197 AELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHPplardatidppAGLMTLSDLRHYRTID 276
Cdd:TIGR00066 159 KDIFNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKN-----------GGIMTKKDLAAYDVEI 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 277 RKPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFDLGSLD--RSQALHYYLEASKLAYADRNRYIGDPAYVAVPQRAL 354
Cdd:TIGR00066 228 RKPLSGDYRGYQVYTTPPPSSGGIHLLQALNILENFDLSQYGdgSAETYQLLAEAMKLSYADRSRYLGDPEFVDVPLEEL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 355 LSESYGKSRSCLIDPIRVLPAPAAPgnpygdhecvpppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVP 434
Cdd:TIGR00066 308 LDKRYAKELAQSIKINKVDPKSTIY-------------PGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAP 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 435 GRGFLLNNELTDFNFTPTQGDAPDPNlaapgKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLR 514
Cdd:TIGR00066 375 DTGILLNNEMDDFSLKPGGANAVEPN-----KRPLSSMAPTIVLKDGKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLA 449
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1906446634 515 DAVAAPRASQRNTPTTV-AEPAFI-ATAGDLTALGHVFTAQP--TIGAAAALEFTP-TQTQAVGEP 575
Cdd:TIGR00066 450 EAVSEPRIHHQWLPDELrLEKGFPdDVLQLLKDMGHKVTLKEvfPMGVVQAIRVDPeGWLYGVSDP 515
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
5-521 1.31e-92

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 296.05  E-value: 1.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634   5 RSTALVTTLLVGCGLVAAPVQAAASTHYAVGTG---------GAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVT 75
Cdd:PRK09615    8 RRVAIAALLSGSCFSAVAAPPAAPPVSYGVEEDvfhpvrakqGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  76 DPMMAGLGGGGYWVhYDARTGRVSTIDGRETTPRAGHERMFVDpATGRAyPFWDAVTSGLSVGTPGMLATWERALRKWGR 155
Cdd:PRK09615   88 HPQAGNLGGGGFML-LRTKNGNTTAIDFREMAPAKATRDMFLD-DQGNP-DSKKSLTSHLASGTPGTVAGFSLALDKYGT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 156 FGLDDALQPAIEVAERGWPLTPVLRQEI-VDNEPRFRQFSSTAELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFY 234
Cdd:PRK09615  165 MPLNKVVQPAFKLARDGFIVNDALADDLkTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFY 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 235 GGAIGRDVVDAVQHPplardatidppAGLMTLSDLRHYRTIDRKPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFDL 314
Cdd:PRK09615  245 KGTIADQIAQEMQKN-----------GGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDM 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 315 -----GSLDrsqALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLSESYGKSRSCLIDPIRVLPAPAAPgnpygdhecv 389
Cdd:PRK09615  314 kkygfGSAD---AMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIR---------- 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 390 pppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGRGFLLNNELTDFNFTP--------TQGDApdpNL 461
Cdd:PRK09615  381 ---PGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAKPgvpnvyglVGGDA---NA 454
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 462 AAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDAVAAPR 521
Cdd:PRK09615  455 VGPNKRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPR 514
 
Name Accession Description Interval E-value
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
39-577 0e+00

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 564.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  39 AVVSDTAEATEAGLRVLRaggtaadaavavaatLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFVD 118
Cdd:COG0405     1 MVATAHPLASQAGLEILRaggnavdaavaaaaaLAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 119 PATGraypfwDAVTSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAE 198
Cdd:COG0405    81 AGDE------IPVRGPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDPGAAA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 199 LFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHPPlardatidppaGLMTLSDLRHYRTIDRK 278
Cdd:COG0405   155 IFLPDGRPPKAGDILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAG-----------GLLTLEDLAAYRAEWRE 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 279 PTHVNYRGYDVYGMAPSSSgGMTVGMALNTLEPFDLGSLDRS--QALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLS 356
Cdd:COG0405   224 PLSGTYRGYTVYSMPPPSQ-GIALLQILNILEGFDLAALGPDsaEYVHLLAEAMKLAFADRDRYLGDPDFVDVPVEGLLS 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 357 ESYGKSRSCLIDPIRVLPAPAapgnpygdhecvpppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGR 436
Cdd:COG0405   303 PAYAAERAALIDPDRATPSPR---------------PGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 437 GFLLNNELTDFNFTPTqgdapDPNLAAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDA 516
Cdd:COG0405   368 GFLLNNRGDDFSLDPG-----HPNALAPGKRPRSTMSPTIVLKDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEA 442
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1906446634 517 VAAPRASQRNTPTTV-AEPAF-IATAGDLTALGHVFTAQPT-IGAAAALEFTPTQT-QAVGEPTR 577
Cdd:COG0405   443 VDAPRWHHQGLPDTLeLEPRFpPAVIAALRARGHKVEVVPDwSGGAQAILRDPDGVlEGAADPRR 507
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
72-579 3.75e-165

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 479.78  E-value: 3.75e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  72 LGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFvdpatGRAYPFWDAVTSGLSVGTPGMLATWERALR 151
Cdd:pfam01019  21 LGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMF-----DGKGDSKLSLTGGLAVGVPGEVAGLAEAHK 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 152 KWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAELFLPGGKVPAVGTIMRNPDLAATYREIARHGTR 231
Cdd:pfam01019  96 RYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQPALAKTLELIAEEGPD 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 232 TFYGGAIGRDVVDAVQHPPlardatidppaGLMTLSDLRHYRTIDRKPTHVNYRGYDVYgMAPSSSGGMTVGMALNTLEP 311
Cdd:pfam01019 176 AFYRGELAQQLVADLQANG-----------GIITAEDLANYRVKIREPLSADYGGYTVY-SPPPSSGGIALLQILNILEG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 312 FDLGS-LDRSQALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLSESYGKSRSCLIDPIRVLPAPAApgnpygdhecvP 390
Cdd:pfam01019 244 FDLSSlLNSAEYLHLLIEAMKLAYADRTRYLGDPDFVPVPVENLLSPEYAKERAKLINPNAAFPSSYA-----------P 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 391 PPPGTAsseneahtnHFVVSDARGNIVSYTNTIEQVGGSGIVVPGRGFLLNNELTDFNFTPTQGDAPDPNLA---APGKR 467
Cdd:pfam01019 313 EDGGTT---------HFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPGNAFGLDPSPAnaiAPGKR 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 468 PRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDAVAAPRASQRNTPTTVAEPAF-IATAGDLTAL 546
Cdd:pfam01019 384 PLSSMAPTIVLDDGKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQLPDVLEVEPGFpEEVLAELEAR 463
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1906446634 547 GHVFTAQPTIGA--AAALEFTPTQT-QAVGEPTRRG 579
Cdd:pfam01019 464 GHKVKVVEDSSSvgAIQIVRRTGGVlYAASDPRRDG 499
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
38-575 2.84e-129

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 388.74  E-value: 2.84e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  38 GAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFV 117
Cdd:TIGR00066   1 GMVASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 118 DpATGRAYPFWDAvTSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRF-RQFSST 196
Cdd:TIGR00066  81 D-KSGNPLPGKSL-TGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLlTTKEDS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 197 AELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHPplardatidppAGLMTLSDLRHYRTID 276
Cdd:TIGR00066 159 KDIFNPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKN-----------GGIMTKKDLAAYDVEI 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 277 RKPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFDLGSLD--RSQALHYYLEASKLAYADRNRYIGDPAYVAVPQRAL 354
Cdd:TIGR00066 228 RKPLSGDYRGYQVYTTPPPSSGGIHLLQALNILENFDLSQYGdgSAETYQLLAEAMKLSYADRSRYLGDPEFVDVPLEEL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 355 LSESYGKSRSCLIDPIRVLPAPAAPgnpygdhecvpppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVP 434
Cdd:TIGR00066 308 LDKRYAKELAQSIKINKVDPKSTIY-------------PGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAP 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 435 GRGFLLNNELTDFNFTPTQGDAPDPNlaapgKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLR 514
Cdd:TIGR00066 375 DTGILLNNEMDDFSLKPGGANAVEPN-----KRPLSSMAPTIVLKDGKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLA 449
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1906446634 515 DAVAAPRASQRNTPTTV-AEPAFI-ATAGDLTALGHVFTAQP--TIGAAAALEFTP-TQTQAVGEP 575
Cdd:TIGR00066 450 EAVSEPRIHHQWLPDELrLEKGFPdDVLQLLKDMGHKVTLKEvfPMGVVQAIRVDPeGWLYGVSDP 515
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
5-521 1.31e-92

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 296.05  E-value: 1.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634   5 RSTALVTTLLVGCGLVAAPVQAAASTHYAVGTG---------GAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVT 75
Cdd:PRK09615    8 RRVAIAALLSGSCFSAVAAPPAAPPVSYGVEEDvfhpvrakqGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  76 DPMMAGLGGGGYWVhYDARTGRVSTIDGRETTPRAGHERMFVDpATGRAyPFWDAVTSGLSVGTPGMLATWERALRKWGR 155
Cdd:PRK09615   88 HPQAGNLGGGGFML-LRTKNGNTTAIDFREMAPAKATRDMFLD-DQGNP-DSKKSLTSHLASGTPGTVAGFSLALDKYGT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 156 FGLDDALQPAIEVAERGWPLTPVLRQEI-VDNEPRFRQFSSTAELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFY 234
Cdd:PRK09615  165 MPLNKVVQPAFKLARDGFIVNDALADDLkTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFY 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 235 GGAIGRDVVDAVQHPplardatidppAGLMTLSDLRHYRTIDRKPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFDL 314
Cdd:PRK09615  245 KGTIADQIAQEMQKN-----------GGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDM 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 315 -----GSLDrsqALHYYLEASKLAYADRNRYIGDPAYVAVPQRALLSESYGKSRSCLIDPIRVLPAPAAPgnpygdhecv 389
Cdd:PRK09615  314 kkygfGSAD---AMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIR---------- 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 390 pppPGTASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGRGFLLNNELTDFNFTP--------TQGDApdpNL 461
Cdd:PRK09615  381 ---PGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAKPgvpnvyglVGGDA---NA 454
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 462 AAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDAVAAPR 521
Cdd:PRK09615  455 VGPNKRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPR 514
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
8-584 3.30e-65

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 223.41  E-value: 3.30e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634   8 ALVTTLLVGCGLVAAPVQAAA--STHYAVGTGGAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVTDPMMAGLGGG 85
Cdd:PLN02198    2 SLVRTVTIVLFIIAFLQNAAAqkRQQSIVASHGAVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  86 GYWVHYDArTGRVSTIDGRETTPRAGHERMFVDPATGRAypfwdavTSGLSVGTPGMLATWERALRKWGRFGLDDALQPA 165
Cdd:PLN02198   82 AFTLIKLA-NGEEIAYDSRETAPLSATENMYGGNVELKK-------KGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 166 IEVAERGWPLTPVLRQEIVDNEPRFRQFSSTAELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDA 245
Cdd:PLN02198  154 EKLAAEGFKISKYLYMQMNATRSDILADKGLSDLFVSNGELKKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRD 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 246 VQhpplardatidPPAGLMTLSDLRHYRTIDRKPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFDLGS-LDRSQALH 324
Cdd:PLN02198  234 IQ-----------KSGGIITLKDLQSYRVKVKEPLSADILGYRVLGMPPPSSGGAAMMLILNILAQYGIPSgVSGPLGVH 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 325 YYLEASKLAYADRNRyIGDPAYVAVPQ--RALLSESYGKS-RSCLIDPIRVLPapaapgNPYGdhecvppppGTASSENE 401
Cdd:PLN02198  303 RLIEALKHAFAVRMN-LGDPDFVDVTKvvSDMLSPKFAQDlKSKINDNKTFDP------KHYG---------GRWNQIDD 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 402 AHTNHFVVSDARGNIVSYTNTIEQVGGSGIVVPGRGFLLNNELTDFNFTPTQGDAPD------PNLAAPGKRPRSSMSPT 475
Cdd:PLN02198  367 HGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSIPMKSGGNLDvpppapANFIRPGKRPLSSMTPT 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 476 IVLRDGKPFLALGSPGGSTIITTVLQILVNRIDFNMPLRDAVAAPRASQRNTPTTVAEPAFIATAGD-----------LT 544
Cdd:PLN02198  447 IVLKDGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAPRIYHQLIPNRASYENWTTVYNDhfeipkatrvvLE 526
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 1906446634 545 ALGHVFTAqptIGAAAALEFTPTQTQ----------AVGEPtRRGGTHAG 584
Cdd:PLN02198  527 KKGHVLSP---IAGGTIAQFIVQESGensggrselvAVSDP-RKGGFPSG 572
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
38-542 1.90e-58

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 206.45  E-value: 1.90e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634  38 GAVVSDTAEATEAGLRVLRAGGTAADAAVAVAATLGVTDPMMAGLGGGGYWVHYDARTGRVSTIDGRETTPRAGHERMFV 117
Cdd:PLN02180   83 GVVAADDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYK 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 118 DPATGRAYpfwdavtSGLSVGTPGMLATWERALRKWGRFGLDDALQPAIEVAERGWPLTPVLRQEIVDNEPRFRQFSSTA 197
Cdd:PLN02180  163 NDASAKSL-------GALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAMILKDPGLR 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 198 ELFLPGGKVPAVGTIMRNPDLAATYREIARHGTRTFYGGAIGRDVVDAVQHpplardatidpPAGLMTLSDLRHYRTIDR 277
Cdd:PLN02180  236 SVFSRNGQVLKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKK-----------AGGIITMDDLRSYEVLVT 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 278 KPTHVNYRGYDVYGMAPSSSGGMTVGMALNTLEPFD--LGSLDRSQALHYYLEASKLAYADRNRyIGDPAYVAVPQ--RA 353
Cdd:PLN02180  305 DAMSVDVMGYTIHGMPPPSGGTLGFSMVIDILDSYSnlYTASGRELGLHRLIEAMKHMFAARMD-LGDPEFVNITNamNQ 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 354 LLSESYGKSRSclidpIRVLPAPAAPGNPYGDHecvppppgtASSENEAHTNHFVVSDARGNIVSYTNTIEQVGGSGIVV 433
Cdd:PLN02180  384 MLSKAHAEEIQ-----KRIFDNTTFPPEYYLNR---------WSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLS 449
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1906446634 434 PGRGFLLNNELTDFN----FTPTQGDAPDPNLAAPGKRPRSSMSPTIVLRDGKPFLALGSPGGSTIITTVLQILVNRIDF 509
Cdd:PLN02180  450 PSTGIVLNNEMDDFStpaeITPDMLPPAPTNFIEPNKRPLSSMTPLVITKDGEFVAALGGAGGMHIIPAVLQVFLNCFVL 529
                         490       500       510
                  ....*....|....*....|....*....|...
gi 1906446634 510 NMPLRDAVAAPRASQRNTPTTVAEPAFIATAGD 542
Cdd:PLN02180  530 NMKPKEAVESARIYHRLIPNVVSYENFTAINGD 562
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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