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Conserved domains on  [gi|1915700419|ref|WP_192802453|]
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MULTISPECIES: chemotaxis protein CheW, partial [Campylobacter]

Protein Classification

CheW domain-containing protein( domain architecture ID 378)

CheW domain-containing protein similar to chemotaxis protein CheW that couples methyl-accepting chemoreceptors and histidine kinase CheA and is essential for chemotaxis

Gene Ontology:  GO:0007165|GO:0006935
PubMed:  12011495|10049806

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CheW_like super family cl00256
CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. ...
 1-55 9.52e-06

CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in the chemotaxis associated histidine kinase CheA binds to CheW, suggesting that these domains can interact with each other.


The actual alignment was detected with superfamily member cd00732:

Pssm-ID: 469692  Cd Length: 140  Bit Score: 39.48  E-value: 9.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915700419   1 GFVIDRLTEAIKIHRNRIDPPPETLVKD-KGMIYGIGKRDENIFTILKVEALLKRE 55
Cdd:cd00732    84 GLLVDSVSEVLRLSTDDIQPPPPVLSDInAKFIRGVVKLEGRLLILLDLDKILDER 139
 
Name Accession Description Interval E-value
CheW cd00732
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
 1-55 9.52e-06

CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.


Pssm-ID: 238374  Cd Length: 140  Bit Score: 39.48  E-value: 9.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915700419   1 GFVIDRLTEAIKIHRNRIDPPPETLVKD-KGMIYGIGKRDENIFTILKVEALLKRE 55
Cdd:cd00732    84 GLLVDSVSEVLRLSTDDIQPPPPVLSDInAKFIRGVVKLEGRLLILLDLDKILDER 139
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
1-55 1.56e-05

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 39.09  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915700419   1 GFVIDRLTEAIKIHRNRIDPPPETLVK-DKGMIYGIGKRDENIFTILKVEALLKRE 55
Cdd:COG0835    90 GLLVDSVSGVVRIDPDDIEPPPELLSGgLAPFITGVAKLDDRLILLLDLEKLLAEE 145
 
Name Accession Description Interval E-value
CheW cd00732
CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. ...
 1-55 9.52e-06

CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.


Pssm-ID: 238374  Cd Length: 140  Bit Score: 39.48  E-value: 9.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915700419   1 GFVIDRLTEAIKIHRNRIDPPPETLVKD-KGMIYGIGKRDENIFTILKVEALLKRE 55
Cdd:cd00732    84 GLLVDSVSEVLRLSTDDIQPPPPVLSDInAKFIRGVVKLEGRLLILLDLDKILDER 139
CheW COG0835
Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];
1-55 1.56e-05

Chemotaxis signal transduction protein CheW [Signal transduction mechanisms];


Pssm-ID: 440597  Cd Length: 151  Bit Score: 39.09  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915700419   1 GFVIDRLTEAIKIHRNRIDPPPETLVK-DKGMIYGIGKRDENIFTILKVEALLKRE 55
Cdd:COG0835    90 GLLVDSVSGVVRIDPDDIEPPPELLSGgLAPFITGVAKLDDRLILLLDLEKLLAEE 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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