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Conserved domains on  [gi|1938293724|ref|WP_196221501|]
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HAMP domain-containing sensor histidine kinase [Sansalvadorimonas verongulae]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-415 7.78e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.56  E-value: 7.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 140 LWTGRYMILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATLEVHQLANSLNAYRSRLGELIER 219
Cdd:COG0642    30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 220 ERSFTRYASHEFRTPLTVIRGVGALLDVSSEPEfIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKTALE-VD-HSFL 297
Cdd:COG0642   110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEE-QREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEpVDlAELL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 298 DQIIDDHRQLLRGKAVEVNVSIHKTA-SVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQS----LCIIDSGCGLD 371
Cdd:COG0642   189 EEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIkYTPEGGTVTVSVRREGdrvrISVEDTGPGIP 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938293724 372 --------------KQPDGHQGFGLGLLIVNDICRKYGWDFSLTNNAsGTGCAAEVIF 415
Cdd:COG0642   269 pedlerifepffrtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEP-GKGTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-415 7.78e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.56  E-value: 7.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 140 LWTGRYMILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATLEVHQLANSLNAYRSRLGELIER 219
Cdd:COG0642    30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 220 ERSFTRYASHEFRTPLTVIRGVGALLDVSSEPEfIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKTALE-VD-HSFL 297
Cdd:COG0642   110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEE-QREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEpVDlAELL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 298 DQIIDDHRQLLRGKAVEVNVSIHKTA-SVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQS----LCIIDSGCGLD 371
Cdd:COG0642   189 EEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIkYTPEGGTVTVSVRREGdrvrISVEDTGPGIP 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938293724 372 --------------KQPDGHQGFGLGLLIVNDICRKYGWDFSLTNNAsGTGCAAEVIF 415
Cdd:COG0642   269 pedlerifepffrtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEP-GKGTTFTVTL 325
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
146-415 7.88e-19

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 87.33  E-value: 7.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 146 MILSVLLFTMAAMavlylaKHLTLPLSILERRLRESQTDDLSPLslPVR-ATLEVHQLANSLNAYRSRLGELIERERSFT 224
Cdd:PRK10755   70 MVSLTLLICFQAV------RWITRPLAELQKELEARTADNLTPI--AIHsSTLEIEAVTSALNQLVSRLTSTLDQERLFT 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 225 RYASHEFRTPLTVIRGVGALLDVSSEPE---FIQRQKRrllnaataMNDVIDTLLNLAREEkESLKTALEVDHSFLDQII 301
Cdd:PRK10755  142 ADVAHELRTPLAGIRLHLELLEKQHHIDvapLIARLDQ--------MMHTVEQLLQLARAG-QSFSSGHYQTVKLLEDVI 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 302 DDHRQ----LLRGKAVEVNVSIHKTASVYAPEAV-VRILLSNLIRNAMACTQEG---EVRIVTESQ--SLCIIDSGCGLD 371
Cdd:PRK10755  213 LPSQDelseMLEQRQQTLLLPESAADITVQGDATlLRLLLRNLVENAHRYSPEGstiTIKLSQEDGgaVLAVEDEGPGID 292

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1938293724 372 KQPDG------------HQGFGLGLLIVNDICRKYGWDFSLTNNASGTGCAAEVIF 415
Cdd:PRK10755  293 ESKCGelskafvrmdsrYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWL 348
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 217-387 1.21e-12

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 68.39  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 217 IERERS-FTRYASHEFRTPLTVIRG-VGALLDVSSEP--------EFIQRQKRRllnaataMNDVIDTLLNLAREEKESL 286
Cdd:TIGR02966 110 LEQMRRdFVANVSHELRTPLTVLRGyLETLADGPDEDpeewnralEIMLEQSQR-------MQSLVEDLLTLSRLESAAS 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 287 KTALE-VDHS-FLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQEG---EVRIVTESQSL 361
Cdd:TIGR02966 183 PLEDEpVDMPaLLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGgtiTVRWRRDGGGA 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1938293724 362 C--IIDSGCGLDKQpdgH-------------------QGFGLGLLIV 387
Cdd:TIGR02966 263 EfsVTDTGIGIAPE---HlprlterfyrvdksrsrdtGGTGLGLAIV 306
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 217-280 1.63e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 53.76  E-value: 1.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 217 IERERSFTRYASHEFRTPLTVIRG-VGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAR 280
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGaLELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 221-284 1.08e-08

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 51.44  E-value: 1.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938293724 221 RSFTRYASHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKE 284
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
174-386 1.15e-08

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 56.96  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 174 LERRLRESQTDDLsplslpvrATLEV--HQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALLdVSSEP 251
Cdd:NF040691  231 LSERMPVKGEDDL--------ARLARsfNQMADSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVI-HDSRD 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 252 EFIQRQKR--RLLNAATA-MNDVIDTLLNLAREEKESlkTALEVDHSFL----DQIIDDHRQLLRGKAVEVNVSIHKTAS 324
Cdd:NF040691  302 DFDPATARsaELLHTELDrFESLLSDLLEISRFDAGA--AELDVEPVDLrplvRRVVDALRQLAERAGVELRVDAPGTPV 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 325 VYA--PEAVVRIlLSNLIRNAMACTQEGEVRIVTESQ----SLCIIDSGCGLDKQPDGH----------------QGFGL 382
Cdd:NF040691  380 VAEvdPRRVERV-LRNLVVNAIEHGEGKPVVVTVAQDdtavAVTVRDHGVGLKPGEVALvfdrfwradpararttGGTGL 458


                  ....
gi 1938293724 383 GLLI 386
Cdd:NF040691  459 GLAI 462
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 332-415 2.69e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.50  E-value: 2.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  332 VRILLSNLIRNAM-ACTQEGEVRIVTESQ----SLCIIDSGCGL---------------DKQPDGHQGFGLGLLIVNDIC 391
Cdd:smart00387   6 LRQVLSNLLDNAIkYTPEGGRITVTLERDgdhvEITVEDNGPGIppedlekifepffrtDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....
gi 1938293724  392 RKYGWDFSLTNNaSGTGCAAEVIF 415
Cdd:smart00387  86 ELHGGEISVESE-PGGGTTFTITL 108
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
134-357 3.39e-07

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 52.14  E-value: 3.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 134 STPQRYLWtgrymILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATlEVHQLANSLNAYRSRL 213
Cdd:NF012163  160 SQQKRASW-----LIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSND-ELGKLAQDFNQLASTL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 214 GELIERERSFTRYASHEFRTPLTVIRGvgalldvssEPEFIQRQKRRLL--NAATAMNDV------IDTLLNLAREEKES 285
Cdd:NF012163  234 EKNEQMRRDFMADISHELRTPLAVLRA---------ELEAIQDGIRKFTpeSLDSLQAEVgtltklVDDLHDLSMSDEGA 304

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 286 LKTAL-EVDH-SFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQE-GEVRIVTE 357
Cdd:NF012163  305 LAYQKaSVDLvPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISAS 379
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-415 7.78e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.56  E-value: 7.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 140 LWTGRYMILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATLEVHQLANSLNAYRSRLGELIER 219
Cdd:COG0642    30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 220 ERSFTRYASHEFRTPLTVIRGVGALLDVSSEPEfIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKTALE-VD-HSFL 297
Cdd:COG0642   110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEE-QREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEpVDlAELL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 298 DQIIDDHRQLLRGKAVEVNVSIHKTA-SVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQS----LCIIDSGCGLD 371
Cdd:COG0642   189 EEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIkYTPEGGTVTVSVRREGdrvrISVEDTGPGIP 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1938293724 372 --------------KQPDGHQGFGLGLLIVNDICRKYGWDFSLTNNAsGTGCAAEVIF 415
Cdd:COG0642   269 pedlerifepffrtDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEP-GKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
206-415 2.01e-28

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 111.92  E-value: 2.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 206 LNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALL--DVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEK 283
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLldEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 284 ESLKTALE-VD-HSFLDQIIDDHRQLLRGKAVEVNVSIH-KTASVYAPEAVVRILLSNLIRNAMACTQEG-EVRIVTESQ 359
Cdd:COG2205    82 GKLSLELEpVDlAELLEEAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARRE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938293724 360 S----LCIIDSGCGLDKQ--------------PDGHQGFGLGLLIVNDICRKYGWDFSLTNNAsGTGCAAEVIF 415
Cdd:COG2205   162 GdgvrISVSDNGPGIPEEeleriferfyrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEP-GGGTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
93-402 1.08e-20

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 93.46  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  93 LGIDEFEIEENVTEYMVYALPDPHLSGHTVYIVMDIVRLENSTPQRYLWTGRYMILSVLLFTMAAMAVLYLAKHLTLPLS 172
Cdd:COG5002    36 LLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 173 ILERRLRESQTDDLSPLSLPVRATLEVHQLANSLNAYR--SRLGELIERERSFTRYASHEFRTPLTVIRG-VGALLD-VS 248
Cdd:COG5002   116 ALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERdiTELERLEQMRREFVANVSHELRTPLTSIRGyLELLLDgAA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 249 SEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKTALE-VD-HSFLDQIIDDHRQLLRGKAVEVNVSIHKT-ASV 325
Cdd:COG5002   196 DDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEpVDlAELLEEVVEELRPLAEEKGIELELDLPEDpLLV 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 326 YAPEAVVRILLSNLIRNAMACTQEG-EVRIVTESQS----LCIIDSGCGLDK--QP--------------DGHQGFGLGL 384
Cdd:COG5002   276 LGDPDRLEQVLTNLLDNAIKYTPEGgTITVSLREEDdqvrISVRDTGIGIPEedLPriferfyrvdksrsRETGGTGLGL 355

                         330
                  ....*....|....*...
gi 1938293724 385 LIVNDICRKYGWDFSLTN 402
Cdd:COG5002   356 AIVKHIVEAHGGRIWVES 373
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
146-415 7.88e-19

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 87.33  E-value: 7.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 146 MILSVLLFTMAAMavlylaKHLTLPLSILERRLRESQTDDLSPLslPVR-ATLEVHQLANSLNAYRSRLGELIERERSFT 224
Cdd:PRK10755   70 MVSLTLLICFQAV------RWITRPLAELQKELEARTADNLTPI--AIHsSTLEIEAVTSALNQLVSRLTSTLDQERLFT 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 225 RYASHEFRTPLTVIRGVGALLDVSSEPE---FIQRQKRrllnaataMNDVIDTLLNLAREEkESLKTALEVDHSFLDQII 301
Cdd:PRK10755  142 ADVAHELRTPLAGIRLHLELLEKQHHIDvapLIARLDQ--------MMHTVEQLLQLARAG-QSFSSGHYQTVKLLEDVI 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 302 DDHRQ----LLRGKAVEVNVSIHKTASVYAPEAV-VRILLSNLIRNAMACTQEG---EVRIVTESQ--SLCIIDSGCGLD 371
Cdd:PRK10755  213 LPSQDelseMLEQRQQTLLLPESAADITVQGDATlLRLLLRNLVENAHRYSPEGstiTIKLSQEDGgaVLAVEDEGPGID 292

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1938293724 372 KQPDG------------HQGFGLGLLIVNDICRKYGWDFSLTNNASGTGCAAEVIF 415
Cdd:PRK10755  293 ESKCGelskafvrmdsrYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWL 348
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 133-410 2.68e-18

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 86.82  E-value: 2.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 133 NSTPQRYLWTGRYMILSVLLftMAAMAVLYLAKHLtlplsileRRLREsQTDDLS---PLSLPVRATLEVHQLANSLNAY 209
Cdd:PRK11100  178 KRSERRILWAGALLLGIALL--IGAGVVWWLNRSI--------RRLTR-YADAVTegkPVPLPKLGSSELRELAQALESM 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 210 RSRL-G-ELIERE-RSFTryasHEFRTPLTVIRGVGALLDVSSEPE----F---IQRQKRRllnaataMNDVIDTLLNLA 279
Cdd:PRK11100  247 RVKLeGkAYVEQYvQTLT----HELKSPLAAIRGAAELLQEDPPPEdrarFtgnILTQSAR-------LQQLIDRLLELA 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 280 R-EEKESLKTALEVD-HSFLDQIIDDHRQLLRGKAVEVNVSIhKTASVYAPEAVVRILLSNLIRNAMACT-QEGEVRIVT 356
Cdd:PRK11100  316 RlEQRQELEVLEPVAlAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSA 394

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938293724 357 ESQS----LCIIDSGCG-----LDK---------QPDGHQ-GFGLGLLIVNDICRKYGWDFSLTNNASGTGCA 410
Cdd:PRK11100  395 EVDGeqvaLSVEDQGPGipdyaLPRiferfyslpRPANGRkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLA 467
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 228-415 7.05e-17

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 82.32  E-value: 7.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 228 SHEFRTPLTVIRGVGALL------DVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKtalEVDhsfLDQII 301
Cdd:COG5000   209 AHEIKNPLTPIQLSAERLrrkladKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLE---PVD---LNELL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 302 DDHRQLLRGKAVEVNVSIHKTASVYAPEAVV-----RILLSNLIRNAM-ACTQEGEVRIVTESQS----LCIIDSGCGLD 371
Cdd:COG5000   283 REVLALYEPALKEKDIRLELDLDPDLPEVLAdrdqlEQVLINLLKNAIeAIEEGGEIEVSTRREDgrvrIEVSDNGPGIP 362

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1938293724 372 KQPDGH----------QGFGLGLLIVNDICRKYGWDFSLTNNaSGTGCAAEVIF 415
Cdd:COG5000   363 EEVLERifepffttkpKGTGLGLAIVKKIVEEHGGTIELESR-PGGGTTFTIRL 415
PRK10337 PRK10337
sensor protein QseC; Provisional
 155-410 3.64e-15

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 77.00  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 155 MAAMAVLYLAKHLTlPLSILERRLRESQTDDLSPLSLPvRATLEVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTP 234
Cdd:PRK10337  174 MLIILMVLLGRELA-PLKKLALALRMRDPDSETPLNAT-GVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 235 LTVIRGVGALLDVSSEPEfiQRQKRRLLN------AATAMndvIDTLLNLAREEKES-LKTALEVD-HSFLDQIIDDHRQ 306
Cdd:PRK10337  252 LAALKVQTEVAQLSDDDP--QARKKALLQlhagidRATRL---VDQLLTLSRLDSLDnLQDVAEIPlEDLLQSAVMDIYH 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 307 LLRGKAVEVNVSIHKTASVYAPEA-----VVRILLSNLIRnamACTQEGEVRIVTESQSLCIIDSGCGLDKQ-------- 373
Cdd:PRK10337  327 TAQQAGIDVRLTLNAHPVIRTGQPlllslLVRNLLDNAIR---YSPQGSVVDVTLNARNFTVRDNGPGVTPEalariger 403

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1938293724 374 ---PDGHQ--GFGLGLLIVNDICRKYGWDFSLTNNASGTGCA 410
Cdd:PRK10337  404 fyrPPGQEatGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEA 445
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 229-395 6.77e-15

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 75.61  E-value: 6.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 229 HEFRTPLTVIRG----VGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKtalEVDhsfLDQIIDDH 304
Cdd:COG4191   151 HEINNPLAAILGnaelLRRRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEERE---PVD---LNELIDEA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 305 RQLLRGKAVEVNVSIHK-----TASVYAPEAVVRILLSNLIRN---AMACTQEGEVRIVTESQS----LCIIDSGCGLDK 372
Cdd:COG4191   225 LELLRPRLKARGIEVELdlppdLPPVLGDPGQLEQVLLNLLINaidAMEEGEGGRITISTRREGdyvvISVRDNGPGIPP 304

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1938293724 373 Q-------------PDGhQGFGLGLLIVNDICRKYG 395
Cdd:COG4191   305 EvlerifepffttkPVG-KGTGLGLSISYGIVEKHG 339
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 217-387 1.21e-12

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 68.39  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 217 IERERS-FTRYASHEFRTPLTVIRG-VGALLDVSSEP--------EFIQRQKRRllnaataMNDVIDTLLNLAREEKESL 286
Cdd:TIGR02966 110 LEQMRRdFVANVSHELRTPLTVLRGyLETLADGPDEDpeewnralEIMLEQSQR-------MQSLVEDLLTLSRLESAAS 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 287 KTALE-VDHS-FLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQEG---EVRIVTESQSL 361
Cdd:TIGR02966 183 PLEDEpVDMPaLLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGgtiTVRWRRDGGGA 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1938293724 362 C--IIDSGCGLDKQpdgH-------------------QGFGLGLLIV 387
Cdd:TIGR02966 263 EfsVTDTGIGIAPE---HlprlterfyrvdksrsrdtGGTGLGLAIV 306
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
229-395 1.02e-11

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 66.02  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 229 HEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKtalEVDhsfLDQIIDDHRQLL 308
Cdd:COG3852   144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPERE---PVN---LHEVLERVLELL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 309 RgKAVEVNVSIHKTAS-----VYA-PEAVVRILLsNLIRNAM-ACTQEGEVRIVTESQS--------------LCIIDSG 367
Cdd:COG3852   218 R-AEAPKNIRIVRDYDpslpeVLGdPDQLIQVLL-NLVRNAAeAMPEGGTITIRTRVERqvtlgglrprlyvrIEVIDNG 295

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1938293724 368 CGLdkqPDGHQ-------------GFGLGLLIVNDICRKYG 395
Cdd:COG3852   296 PGI---PEEILdrifepffttkekGTGLGLAIVQKIVEQHG 333
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
229-395 6.29e-11

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 64.22  E-value: 6.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 229 HEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKtalEVDhsfLDQIIDDHRQLL 308
Cdd:PRK11360  399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQ---PVS---LNALVEEVLQLF 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 309 R--GKAVEVNVSIHKTASVYA----PEAVVRILLsNLIRNAM-ACTQEGEVRIVTES-----QSLCIIDSGCGLDKQPDG 376
Cdd:PRK11360  473 QtaGVQARVDFETELDNELPPiwadPELLKQVLL-NILINAVqAISARGKIRIRTWQysdgqVAVSIEDNGCGIDPELLK 551

                         170       180
                  ....*....|....*....|....*....
gi 1938293724 377 H----------QGFGLGLLIVNDICRKYG 395
Cdd:PRK11360  552 KifdpffttkaKGTGLGLALSQRIINAHG 580
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 217-280 1.63e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 53.76  E-value: 1.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 217 IERERSFTRYASHEFRTPLTVIRG-VGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAR 280
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGaLELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
TMAO_torS TIGR02956
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ...
 177-386 5.53e-09

TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]


Pssm-ID: 274362 [Multi-domain]  Cd Length: 968  Bit Score: 58.64  E-value: 5.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 177 RLRESQTDDLSPLSLPVRATLEVHQLANSLnayrsrlGELIERERS-FTRYASHEFRTPLTVIRGVGALLDVSSEPEFIQ 255
Cdd:TIGR02956 427 QLVAQRTQELAETNERLNAEVKNHAKARAE-------AEEANRAKSaFLATMSHEIRTPLNGILGTLELLGDTGLTSQQQ 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 256 RQKRRLLNAATAMNDVIDTLLNLAREEKESLktALEVDHSFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVV--- 332
Cdd:TIGR02956 500 QYLQVINRSGESLLDILNDILDYSKIEAGHL--SISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLPNWWQgdg 577

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938293724 333 ---RILLSNLIRNAMACTQEGEVRIVT----ESQSL-CIIDSGCGLDK-----------QPDGHQ---GFGLGLLI 386
Cdd:TIGR02956 578 priRQVLINLVGNAIKFTDRGSVVLRVslndDSSLLfEVEDTGCGIAEeeqatlfdaftQADGRRrsgGTGLGLAI 653
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 221-284 1.08e-08

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 51.44  E-value: 1.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938293724 221 RSFTRYASHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKE 284
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
174-386 1.15e-08

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 56.96  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 174 LERRLRESQTDDLsplslpvrATLEV--HQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALLdVSSEP 251
Cdd:NF040691  231 LSERMPVKGEDDL--------ARLARsfNQMADSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVI-HDSRD 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 252 EFIQRQKR--RLLNAATA-MNDVIDTLLNLAREEKESlkTALEVDHSFL----DQIIDDHRQLLRGKAVEVNVSIHKTAS 324
Cdd:NF040691  302 DFDPATARsaELLHTELDrFESLLSDLLEISRFDAGA--AELDVEPVDLrplvRRVVDALRQLAERAGVELRVDAPGTPV 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 325 VYA--PEAVVRIlLSNLIRNAMACTQEGEVRIVTESQ----SLCIIDSGCGLDKQPDGH----------------QGFGL 382
Cdd:NF040691  380 VAEvdPRRVERV-LRNLVVNAIEHGEGKPVVVTVAQDdtavAVTVRDHGVGLKPGEVALvfdrfwradpararttGGTGL 458


                  ....
gi 1938293724 383 GLLI 386
Cdd:NF040691  459 GLAI 462
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 332-415 2.69e-08

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 51.50  E-value: 2.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  332 VRILLSNLIRNAM-ACTQEGEVRIVTESQ----SLCIIDSGCGL---------------DKQPDGHQGFGLGLLIVNDIC 391
Cdd:smart00387   6 LRQVLSNLLDNAIkYTPEGGRITVTLERDgdhvEITVEDNGPGIppedlekifepffrtDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....
gi 1938293724  392 RKYGWDFSLTNNaSGTGCAAEVIF 415
Cdd:smart00387  86 ELHGGEISVESE-PGGGTTFTITL 108
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 228-373 3.08e-08

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 55.26  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 228 SHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRL----LNAAtamNDVIDTLLNLAREEKESLKTaLEVDHSfLDQIIDD 303
Cdd:COG5806   209 AHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIaleeLDRA---EAIITDYLTFAKPQPEKLEK-IDVSEE-LEHVIDV 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 304 HRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQS----LCIIDSGCGLDKQ 373
Cdd:COG5806   284 LSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIeAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKE 358
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 221-284 5.10e-08

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 49.49  E-value: 5.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938293724  221 RSFTRYASHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKE 284
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
PRK15347 PRK15347
two component system sensor kinase;
147-395 8.64e-08

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 54.65  E-value: 8.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 147 ILSVLLFTMAAMAVLYLAKHL---------TLPLSiLERRLRESQTDDL-------SPLSLPVRA---TLE--VHQLANS 205
Cdd:PRK15347  305 ILVLLTSVLFLLLRRYLAKPLwrfvdiinkTGPAA-LEPRLPENRLDELgsiakayNQLLDTLNEqydTLEnkVAERTQA 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 206 LNAYRSRLGELIERERSFTRYASHEFRTPLTVIrgVGALldvssepEFIQR-----QKRRLLNaaTAMN------DVIDT 274
Cdd:PRK15347  384 LAEAKQRAEQANKRKSEHLTTISHEIRTPLNGV--LGAL-------ELLQNtpltaEQMDLAD--TARQctlsllAIINN 452

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 275 LLNLAREEKESLKTALEvdHSFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAV------VRILLSNLIRNAMACTQ 348
Cdd:PRK15347  453 LLDFSRIESGQMTLSLE--ETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLhldslrLRQILVNLLGNAVKFTE 530

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938293724 349 EGEV--RIVTESQSLCII--DSGCGLDK-----------QPDGH-QGFGLGLLIVNDICRKYG 395
Cdd:PRK15347  531 TGGIrlRVKRHEQQLCFTveDTGCGIDIqqqqqiftpfyQADTHsQGTGLGLTIASSLAKMMG 593
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 332-415 9.32e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 50.06  E-value: 9.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 332 VRILLSNLIRNAM-ACTQEGEVRIVTESQ---SLCIIDSGCGLDKQP-------------DGHQGFGLGLLIVNDICRKY 394
Cdd:pfam02518   6 LRQVLSNLLDNALkHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDlprifepfstadkRGGGGTGLGLSIVRKLVELL 85

                          90       100
                  ....*....|....*....|.
gi 1938293724 395 GWDFSLTnNASGTGCAAEVIF 415
Cdd:pfam02518  86 GGTITVE-SEPGGGTTVTLTL 105
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 229-390 9.57e-08

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 53.97  E-value: 9.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 229 HEFRTPLTVIRGVGALLDVSSE--PEFIQrqkrRLLNAATAMNDVIDTLLNLAREEKESLKTALevdhsfLDQIIDDHRQ 306
Cdd:COG5805   296 HEIRNPLTSIKGFLQLLQPGIEdkEEYFD----IMLSELDRIESIISEFLALAKPQAVNKEKEN------INELIQDVVT 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 307 LLRGKAVEVNVSIH-----KTASVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQ----SLCIIDSGCGLDKQPDG 376
Cdd:COG5805   366 LLETEAILHNIQIRlelldEDPFIYCDENQIKQVFINLIKNAIeAMPNGGTITIHTEEEdnsvIIRVIDEGIGIPEERLK 445

                         170       180
                  ....*....|....*....|....
gi 1938293724 377 H----------QGFGLGLLIVNDI 390
Cdd:COG5805   446 KlgepffttkeKGTGLGLMVSYKI 469
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
 125-414 1.41e-07

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 53.98  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 125 VMDIVRLENSTPQ----RYLWTGRYMILSVLLFTMAAMAVLYLAKHLtlplSILERRLR---ESQTDDLSPLS---LPVR 194
Cdd:TIGR03785 384 VLGAVIAEQTTNGirtlRNSALEKLFNVILAIMSIGTLALFGFASWI----SWRIRRLSddaEAAIDSQGRISgaiPASR 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 195 ATLEVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLLNAATAMNDVIDT 274
Cdd:TIGR03785 460 SRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQKYLERAREGTERLSMILNN 539

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 275 LLNLAREEkESLKTAlEVDHSFLDQIIDD----HRQLLRGKAVEVNvsIHKTASVY--APEAVVRiLLSNLIRNAMACTQ 348
Cdd:TIGR03785 540 MSEATRLE-QAIQSA-EVEDFDLSEVLSGcmqgYQMTYPPQRFELN--IPETPLVMrgSPELIAQ-MLDKLVDNAREFSP 614

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 349 EG---EVRI-VTESQSLC----------------IIDSGCGLDKQPDGHQG-FGLGLLIVNDICRKYGWDFSLTNNASGT 407
Cdd:TIGR03785 615 EDgliEVGLsQNKSHALLtvsnegpplpedmgeqLFDSMVSVRDQGAQDQPhLGLGLYIVRLIADFHQGRIQAENRQQND 694


                  ....*..
gi 1938293724 408 GCAAEVI 414
Cdd:TIGR03785 695 GVVFRIS 701
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
221-387 1.49e-07

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 53.48  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 221 RSFTRYASHEFRTPLTVIRGvgaLLDVSSEPEFIQRQKRRLLNAATA----MNDVIDTLLNLAR-EEKESLKTALEVDHS 295
Cdd:PRK11006  205 RNFFANVSHELRTPLTVLQG---YLEMMQDQPLEGALREKALHTMREqtqrMEGLVKQLLTLSKiEAAPTIDLNEKVDVP 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 296 FLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQEG---EVRIVTESQSLC--IIDSGCGL 370
Cdd:PRK11006  282 MMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGthiTVRWQRVPQGAEfsVEDNGPGI 361

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1938293724 371 ---------------DKQPDGHQ-GFGLGLLIV 387
Cdd:PRK11006  362 apehiprlterfyrvDKARSRQTgGSGLGLAIV 394
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
134-357 3.39e-07

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 52.14  E-value: 3.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 134 STPQRYLWtgrymILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATlEVHQLANSLNAYRSRL 213
Cdd:NF012163  160 SQQKRASW-----LIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSND-ELGKLAQDFNQLASTL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 214 GELIERERSFTRYASHEFRTPLTVIRGvgalldvssEPEFIQRQKRRLL--NAATAMNDV------IDTLLNLAREEKES 285
Cdd:NF012163  234 EKNEQMRRDFMADISHELRTPLAVLRA---------ELEAIQDGIRKFTpeSLDSLQAEVgtltklVDDLHDLSMSDEGA 304

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 286 LKTAL-EVDH-SFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQE-GEVRIVTE 357
Cdd:NF012163  305 LAYQKaSVDLvPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISAS 379
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
137-390 4.29e-07

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 51.94  E-value: 4.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 137 QRYLWtgryMI--LSVLLftmAAMAVLYLAKHLTLPLsileRRLRESqTDDLSPLSLPVRATL----EVHQLANSLNAYR 210
Cdd:PRK10549  163 RRTSW----LIvaLSTLL---AALATFLLARGLLAPV----KRLVEG-THKLAAGDFTTRVTPtsrdELGRLAQDFNQLA 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 211 SRLGELIERERSFTRYASHEFRTPLTVIRGvgalldvssEPEFIQRQKRR--------LLNAATAMNDVIDTLLNLAREE 282
Cdd:PRK10549  231 STLEKNEQMRRDFMADISHELRTPLAVLRG---------ELEAIQDGVRKftpesvasLQAEVGTLTKLVDDLHQLSLSD 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 283 KESL---KTALEVDHsFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAMACTQE-GEVRIVTES 358
Cdd:PRK10549  302 EGALayrKTPVDLVP-LLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSgGSLHISAEQ 380

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1938293724 359 QS----LCIIDSGCGL-DKQ----------PDGHQ-----GFGLGLLIVNDI 390
Cdd:PRK10549  381 RDktlrLTFADSAPGVsDEQlqklferfyrTEGSRnrasgGSGLGLAICLNI 432
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 228-390 6.10e-07

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 51.51  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 228 SHEFRTPLTVIRGvgalldvssepeFIQrqkrrLLNAAT----------------AMNDVIDTLLNLAREEkeslktALE 291
Cdd:COG5809   278 AHEIRNPLTSLKG------------FIQ-----LLKDTIdeeqktyldimlseldRIESIISEFLVLAKPQ------AIK 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 292 VDHSFLDQIIDDHRQLLRGKAVEVNVSI-----HKTASVYAPEAVVRILLSNLIRNAM-ACTQEGEVRIVTESQS----- 360
Cdd:COG5809   335 YEPKDLNTLIEEVIPLLQPQALLKNVQIeleleDDIPDILGDENQLKQVFINLLKNAIeAMPEGGNITIETKAEDddkvv 414

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1938293724 361 LCIIDSGCGLDK-------QP---DGHQGFGLGLLIVNDI 390
Cdd:COG5809   415 ISVTDEGCGIPEerlkklgEPfytTKEKGTGLGLMVSYKI 454
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 198-403 2.21e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 49.46  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 198 EVHQLANSLNAYRSRLGELiereRSFTryasHEFRTPLTVIRGvgaLLDVSSEPE---FIQRQKRRLLNAATAM-----N 269
Cdd:COG3290   175 ELERLEEELEGVKELAEAL----RAQR----HDFRNHLHTISG---LLQLGEYDEaleYIDEISEELQELIDSLlsrigN 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 270 DVIDTLL----NLAREEKESLKtaLEVDHSFLDQIIDDHrqllrgkavevnvsihktasvyapeAVVRILlSNLIRNAM- 344
Cdd:COG3290   244 PVLAALLlgkaARARERGIDLT--IDIDSDLPDLPLSDT-------------------------DLVTIL-GNLLDNAIe 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 345 ACTQEG------EVRIVTESQSLCII--DSGCGLD--------------KQPDGHqgfGLGLLIVNDICRKYGWDFSLTN 402
Cdd:COG3290   296 AVEKLPeeerrvELSIRDDGDELVIEveDSGPGIPeellekifergfstKLGEGR---GLGLALVKQIVEKYGGTIEVES 372


                  .
gi 1938293724 403 N 403
Cdd:COG3290   373 E 373
PRK09303 PRK09303
histidine kinase;
174-393 9.54e-06

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 47.64  E-value: 9.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 174 LERRLRESQTDDLsplslpvRATLEVHQLANSLNAYRSRLGELIER----ERsFTRYASHEFRTPLTvirgvGALLDV-- 247
Cdd:PRK09303  109 LGENLQPSEIDSG-------RYSQELLQLSDELFVLRQENETLLEQlkfkDR-VLAMLAHDLRTPLT-----AASLALet 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 248 ------SSEPEFIQRQKRRLLNAATA----MNDVIDTLLNLAREEKESLKT-ALEVDHSFLDQ-IIDDHRQLLRGKAVEV 315
Cdd:PRK09303  176 lelgqiDEDTELKPALIEQLQDQARRqleeIERLITDLLEVGRTRWEALRFnPQKLDLGSLCQeVILELEKRWLAKSLEI 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 316 NVSIHKT-ASVYAPEAVVRILLSNLIRNAMACTQE-GEVRIV-----TESQSLCIIDSGCG----------LD----KQP 374
Cdd:PRK09303  256 QTDIPSDlPSVYADQERIRQVLLNLLDNAIKYTPEgGTITLSmlhrtTQKVQVSICDTGPGipeeeqerifEDrvrlPRD 335

                         250
                  ....*....|....*....
gi 1938293724 375 DGHQGFGLGLlivnDICRK 393
Cdd:PRK09303  336 EGTEGYGIGL----SVCRR 350
PRK10604 PRK10604
sensor protein RstB; Provisional
 201-395 1.44e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 46.91  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 201 QLANSLNAyrsrlgeLIERERSFTRYASHEFRTPLTVIRGVGALLDVSSEPEfIQRQKRRLlnaaTAMNDVIDTLLNLAR 280
Cdd:PRK10604  200 QMADNINA-------LIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAE-SQALNRDI----GQLEALIEELLTYAR 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 281 EEKESLKTAL-EVD-HSFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRIlLSNLIRNAMA-CTQEGEVRIVTE 357
Cdd:PRK10604  268 LDRPQNELHLsEPDlPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERV-LDNLLNNALRyAHSRVRVSLLLD 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1938293724 358 SQSLCII--DSGCG---------------LDKQPDGHQ-GFGLGLLIVNDICRKYG 395
Cdd:PRK10604  347 GNQACLIveDDGPGippeerervfepfvrLDPSRDRATgGCGLGLAIVHSIALAMG 402
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
198-403 6.36e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 45.50  E-value: 6.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  198 EVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGvgaLLDVSSEPEFIQRQKRRLLNAATAMNDVIDTLLN 277
Cdd:PRK09959   690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMG---FLELLSGSGLSKEQRVEAISLAYATGQSLLGLIG 766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  278 --LAREEKESLKTALEVDHSFLDQIIDDHRQLLRGKAVEVNVSIhKTASVYAPEAVVRI-------LLSNLIRNAMACTQ 348
Cdd:PRK09959   767 eiLDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIAL-SCSSTFPDHYLVKIdpqafkqVLSNLLSNALKFTT 845

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1938293724  349 EGEVRIVTE---------SQSLCIIDSGCGLDKQPD------------GHQ--GFGLGLLIVNDICRKYGWDFSLTNN 403
Cdd:PRK09959   846 EGAVKITTSlghiddnhaVIKMTIMDSGSGLSQEEQqqlfkrysqtsaGRQqtGSGLGLMICKELIKNMQGDLSLESH 923
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 297-415 1.10e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 41.85  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 297 LDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAVVRILLSNLIRNAM----------ACTQEGEVRI--------VTES 358
Cdd:cd16954     3 LDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACkwclefvevtARQTDGGLHLivdddgpgVPES 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938293724 359 QSLCIIDSGCGLDKQpdgHQGFGLGLLIVNDICRKYGWDFSLTNNASGtGCAAEVIF 415
Cdd:cd16954    83 QRSKIFQRGQRLDEQ---RPGQGLGLAIAKEIVEQYGGELSLSDSPLG-GARFEVVF 135
PRK10490 PRK10490
sensor protein KdpD; Provisional
 197-409 1.65e-04

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 44.26  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 197 LEVHQLANSlnAYRSRLGelIERER---SFTRYASHEFRTPLTVIRGVGALL--DVSSE--PEFIQ----RQKrrLLNAA 265
Cdd:PRK10490  642 LERLTLTAS--EEQARLA--SEREQlrnALLAALSHDLRTPLTVLFGQAEILtlDLASEgsPHARQaseiRQQ--VLNTT 715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 266 TAMNDvidtLLNLAREEKESLKTALEvdHSFLDQIIDDH-RQL---LRGKAVEVNVS-----IHKTASVYapEAVVRILL 336
Cdd:PRK10490  716 RLVNN----LLDMARIQSGGFNLRKE--WLTLEEVVGSAlQMLepgLSGHPINLSLPepltlIHVDGPLF--ERVLINLL 787

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 337 SNLIRNAMACTQEGeVRIVTESQSLCII--DSGCGL---------DKQPDGHQ-----GFGLGLLIVNDICRKYGWDFSL 400
Cdd:PRK10490  788 ENAVKYAGAQAEIG-IDAHVEGERLQLDvwDNGPGIppgqeqlifDKFARGNKesaipGVGLGLAICRAIVEVHGGTIWA 866


                  ....*....
gi 1938293724 401 TNNASGTGC 409
Cdd:PRK10490  867 ENRPEGGAC 875
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 336-393 2.21e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 40.55  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 336 LSNLIRNAMACTQEGEVRIVTESQS---------LCIIDSGCGLDK-----------QPDG-----HQGFGLGLLivndI 390
Cdd:cd16922     5 LLNLLGNAIKFTEEGEVTLRVSLEEeeedgvqlrFSVEDTGIGIPEeqqarlfepfsQADSsttrkYGGTGLGLA----I 80


                  ...
gi 1938293724 391 CRK 393
Cdd:cd16922    81 SKK 83
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
146-407 2.44e-04

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 43.22  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 146 MILSVLLFTMAAMAVLYLAKHLTLPLSILERRLRESQTDDLSPLSLPVRATLEVHQLANSLNAYRSRLGELIERERSFTR 225
Cdd:PRK09835  188 IMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 226 YASHEFRTPLTVirgvgalLDVSSEPEFIQ-RQKRRL-------LNAATAMNDVIDTLLNLA-------REEKESLKTAL 290
Cdd:PRK09835  268 DIAHEIRTPITN-------LITQTEIALSQsRSQKELedvlysnLEELTRMAKMVSDMLFLAqadnnqlIPEKKMLDLAD 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 291 EVDHSFldqiiddhrQLLRGKAVEVNVSIH---KTASVYAPEAVVRILLSNLIRNAMACTQEGEVRIVTESQS-----LC 362
Cdd:PRK09835  341 EVGKVF---------DFFEAWAEERGVELRfvgDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVdhqvqLV 411

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938293724 363 IIDSGCGL-----------------DKQPDGhQGFGLGLLIVNDICRKYGWDFSLTNNASGT 407
Cdd:PRK09835  412 VENPGTPIapehlprlfdrfyrvdpSRQRKG-EGSGIGLAIVKSIVVAHKGTVAVTSDARGT 472
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 196-402 5.62e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 42.58  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 196 TLEVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALL-DVSSEPEfiQRQKRRLLNAA-----TAMN 269
Cdd:PRK11466  420 TAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLaDNPALNA--QRDDLRAITDSgesllTILN 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 270 DVIDtllnLAREEKESLKTALEVDHSFLDQIIDDHRQLLRGKAVEVNVSIHKTASVYAPEAV------VRILLSNLIRNA 343
Cdd:PRK11466  498 DILD----YSAIEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALmgdprrIRQVITNLLSNA 573

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1938293724 344 MACTQEGEVRIVT----ESQSLCIIDSGCGLD--KQPDGHQGF----------GLGLLIVNDICRKYGWDFSLTN 402
Cdd:PRK11466  574 LRFTDEGSIVLRSrtdgEQWLVEVEDSGCGIDpaKLAEIFQPFvqvsgkrggtGLGLTISSRLAQAMGGELSATS 648
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 332-406 6.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 39.31  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 332 VRILLSNLIRNAMACTQEG---EVRIVTESQSLCII-DSGCGLDKQ-----------PDGH--QGFGLGLLIVNDICRKY 394
Cdd:cd16940    14 LFLLLRNLVDNAVRYSPQGsrvEIKLSADDGAVIRVeDNGPGIDEEelealferfyrSDGQnyGGSGLGLSIVKRIVELH 93

                          90
                  ....*....|..
gi 1938293724 395 GWDFSLTNNASG 406
Cdd:cd16940    94 GGQIFLGNAQGG 105
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-415 1.67e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 37.83  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 329 EAVVRILLsNLIRNAMACTQEGE-VRIVTESQSLC----IIDSGCGLDKQ-----------------PDGHqgFGLGLLI 386
Cdd:cd16975     3 LLLSRALI-NIISNACQYAPEGGtVSISIYDEEEYlyfeIWDNGHGFSEQdlkkalelfyrddtsrrSGGH--YGMGLYI 79

                          90       100
                  ....*....|....*....|....*....
gi 1938293724 387 VNDICRKYGWDFSLTNNASGtgcAAEVIF 415
Cdd:cd16975    80 AKNLVEKHGGSLIIENSQKG---GAEVTV 105
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
228-395 2.05e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 40.15  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 228 SHEFRTPLTVIRGVGALLDVSSEPEFIQRQKRRLL-NAATAMNDVIDTLLNLAREEKESLKT---ALEVDHSfLDQIIDD 303
Cdd:PRK10364  245 AHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMaKEADRLNRVVSELLELVKPTHLALQAvdlNDLINHS-LQLVSQD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 304 HRQllRGKAVEVNVSIHKTASVYAPEAVVRILLsNLIRNAMACTQEGEVRIVTESQS---LCII--DSGCGLDKQPDGH- 377
Cdd:PRK10364  324 ANS--REIQLRFTANDTLPEIQADPDRLTQVLL-NLYLNAIQAIGQHGVISVTASESgagVKISvtDSGKGIAADQLEAi 400

                         170       180
                  ....*....|....*....|....*..
gi 1938293724 378 ---------QGFGLGLLIVNDICRKYG 395
Cdd:PRK10364  401 ftpyfttkaEGTGLGLAVVHNIVEQHG 427
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 334-403 2.13e-03

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 37.58  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 334 ILLSNLIRNAM-ACTQEGEVRIVT-----ESQSLCII------DSGCGLDKQP------DGHqgfGLGLLIVNDICRKYG 395
Cdd:pfam14501   8 VIFGNLLDNAIeACSKIDDNRFIRlkireKQNFLIIRientyeGELKFEGKLPstktkgDGH---GIGLKSIRRIVKKYG 84


                  ....*...
gi 1938293724 396 WDFSLTNN 403
Cdd:pfam14501  85 GNLSTEIE 92
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
196-396 3.02e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.92  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 196 TLEVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALL----DVSSEPEFIQRQKRRLlnaatamNDV 271
Cdd:PRK09470  219 PQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLrrrqGESKELERIETEAQRL-------DSM 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 272 IDTLLNLAREEkesLKTALEVD----HSFLDQIIDDHR----QllRGKAVEVNvSIHKTASVYAPEAVVRILLSNLIRNA 343
Cdd:PRK09470  292 INDLLVLSRNQ---QKNHLEREtfkaNSLWSEVLEDAKfeaeQ--MGKSLTVS-APPGPWPINGNPNALASALENIVRNA 365

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938293724 344 MACTQ-EGEVRIVTESQSLCII--DSGCGL---------------DKQPDGHQ-GFGLGLLIV-NDICRKYGW 396
Cdd:PRK09470  366 LRYSHtKIEVAFSVDKDGLTITvdDDGPGVpeeereqifrpfyrvDEARDRESgGTGLGLAIVeNAIQQHRGW 438
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
6-345 4.16e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 39.71  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724   6 TFRSRIALTFTTLSAIIILIQMVLFYDMVLETEDRVLTNRMELYGKLSLDDFEEDDDGIISVDQLTNAYLGLDKVPEPLR 85
Cdd:COG2770    75 LLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724  86 SLLPPEWLGIDEFEIEENVTEYMVYALPDPHLSGHTVYIVMDIVRLENSTPQRYLWTGRYMILSVLLFTMAAMAVLYLAK 165
Cdd:COG2770   155 AALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLAR 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 166 HLTLPLSILERRLRESQTDDLSpLSLPVRATLEVHQLANSLNAYRSRLGELIERERSFTRYASHEFRTPLTVIRGVGALL 245
Cdd:COG2770   235 RITRPLRRLAEAARRIAAGDLD-VRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLAL 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 246 DVSSEPEFIQRQKRRLLNAATAMNDVIDTLLNLAREEKESLKTALEVDHSFLDQIIDDHRQLLRGKAVEVNVSIHKTASV 325
Cdd:COG2770   314 LLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLA 393

                         330       340
                  ....*....|....*....|
gi 1938293724 326 YAPEAVVRILLSNLIRNAMA 345
Cdd:COG2770   394 LLAALAAALLLLELALEELV 413
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 294-409 8.65e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 38.35  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938293724 294 HSFLDQIIDDHRQLLRGKAVEVNVSIhktASVY-APEAVVRI------LLSNLIRNAMACTQEGEVRIVTESQS----LC 362
Cdd:COG3920   362 RDYLRELLEPLRDSYGGRGIRIELDG---PDVElPADAAVPLglilneLVTNALKHAFLSGEGGRIRVSWRREDgrlrLT 438

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1938293724 363 IIDSGCGLDKQPDGHQGFGLGLLIVNDICRKYGWDFSLTNNAsGTGC 409
Cdd:COG3920   439 VSDNGVGLPEDVDPPARKGLGLRLIRALVRQLGGTLELDRPE-GTRV 484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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