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Conserved domains on  [gi|1941938498|ref|WP_197121682|]
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type III pantothenate kinase [Pseudoalteromonas sp. NZS100]

Protein Classification

type III pantothenate kinase( domain architecture ID 10014198)

type III pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis

CATH:  3.30.420.40
EC:  2.7.1.33
Gene Ontology:  GO:0005524|GO:0016310|GO:0015937|GO:0004594|GO:0046872
PubMed:  16905099|8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13322 PRK13322
pantothenate kinase; Reviewed
 1-234 2.43e-79

pantothenate kinase; Reviewed


:

Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 238.31  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHN-------------EQAQPADINNLPWLQITEVIYACVGRSDLLNDILAQ-AASNNIICFEA 66
Cdd:PRK13322    1 MILELDCGNSRLKWRVIDNggqiiehgahldsPAELLLGLANLASLAPTRCRIVSVLSEEETARLVAIlEKRLGIPVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ 146
Cdd:PRK13322   81 KVAAELAGVRNGYEDPEQLGIDRWLALLGAFHLAKN-ACLVIDCGTAVTIDLVDADGQHLGGYICPGLYLMRDALRTHTR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 147 RVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTDKKTEqKVQIIFAGGYGLLLQQQFEGSIFDSLLVMKGL 226
Cdd:PRK13322  160 RIRYDDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGP-DFEIFLTGGDAPLLADHLPQARVVPDLVFVGL 238


                  ....*...
gi 1941938498 227 NYWHQLSK 234
Cdd:PRK13322  239 AQYCPLSP 246
 
Name Accession Description Interval E-value
PRK13322 PRK13322
pantothenate kinase; Reviewed
 1-234 2.43e-79

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 238.31  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHN-------------EQAQPADINNLPWLQITEVIYACVGRSDLLNDILAQ-AASNNIICFEA 66
Cdd:PRK13322    1 MILELDCGNSRLKWRVIDNggqiiehgahldsPAELLLGLANLASLAPTRCRIVSVLSEEETARLVAIlEKRLGIPVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ 146
Cdd:PRK13322   81 KVAAELAGVRNGYEDPEQLGIDRWLALLGAFHLAKN-ACLVIDCGTAVTIDLVDADGQHLGGYICPGLYLMRDALRTHTR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 147 RVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTDKKTEqKVQIIFAGGYGLLLQQQFEGSIFDSLLVMKGL 226
Cdd:PRK13322  160 RIRYDDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGP-DFEIFLTGGDAPLLADHLPQARVVPDLVFVGL 238


                  ....*...
gi 1941938498 227 NYWHQLSK 234
Cdd:PRK13322  239 AQYCPLSP 246
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-234 2.63e-51

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 166.87  E-value: 2.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHNEQ----------AQPAD-----INNL---PWLQITEVIYACVGRSdlLNDILAQAASNnii 62
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGEllaswrlatdRRTADelaelLRQLlaaLLPDIEGVIISSVVPP--LTEALEELLRK--- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  63 CFEAKV----TKTLGDLVCAYEHVANLGIDRWLALIAGFTLYpNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMT 138
Cdd:COG1521    76 YFGVPPlvvgPGVKTGLKNAYDNPEELGADRIANAVAARELY-GGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 139 SSLTQNTQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTdKKTEQKVQIIFAGGYGLLLQQQFEGSIF- 217
Cdd:COG1521   155 EALHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIK-EELGEDPKVIATGGDAPLLAPELKTIDIv 233

                         250
                  ....*....|....*..
gi 1941938498 218 DSLLVMKGLNYWHQLSK 234
Cdd:COG1521   234 DPDLVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-229 6.76e-42

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 142.40  E-value: 6.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWHNEQ----------------AQPADINNLPWLQITEVIYACVGRSdlLNDILaQAASNNIICFEA 66
Cdd:cd24015     1 LVIDIGNTNIKLGLFDGGElvkiwrlstdkeltedELLLLLAGIELEDISGVVISSVVPS--LTEVL-EEALKKYFGISP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KV--TKTLGDLVCAYEHVANLGIDRWLALIAGFTLYpNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQN 144
Cdd:cd24015    78 LVvgPGLKLGVKIAYDNPKELGADRLANAVAAAKLY-GRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALHQR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 145 TQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTdKKTEQKVQIIFAGGYGLLLQQQFE-GSIFDSLLVM 223
Cdd:cd24015   157 TAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLK-KELGGDAKVILTGGDAKLVAPYLEpIDIYDPDLTL 235


                  ....*.
gi 1941938498 224 KGLNYW 229
Cdd:cd24015   236 KGLKLI 241
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 3-181 5.44e-39

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 133.84  E-value: 5.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWHNEQAQ-----PADINNLP-----WLQ----------ITEVIYACVGrsDLLNDILAQAASN--N 60
Cdd:pfam03309   2 LAIDIGNTNIKWGLFDGDKLVahwriSTDARRTAdelgvLLRsllrlagidpIDGVIISSVV--PPLNAALERACLKyfK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  61 IICFEAKVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSS 140
Cdd:pfam03309  80 IEPLVVGAPGIKTGLRNRYDNPKELGADRWVNAVAARELYPGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLDA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1941938498 141 LTQNTQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIE 181
Cdd:pfam03309 160 LAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVE 200
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 3-226 1.38e-22

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 92.15  E-value: 1.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWH----NEQAQPADINNLPWLQITEVIYACVGRSdlLNDILAQAA--SNN----IICFEAKVTKTL 72
Cdd:TIGR00671   2 LLIDVGNTRIVFALNSgnkvYQFWRLATNLMKTYDEHSEFLKELFGKS--LNKAFISSVvpELTeavrNMIPKIKNIKPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  73 GDLVCAYEHVAN-------LGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNT 145
Cdd:TIGR00671  80 IFFPLVYDGLPNlykspkeLGIDRVANALAAIKFYGF-NVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHALKDRA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 146 ---QRVFDDskTPfTNELGKNTPNGLKNGALVATIGAIeQAKLHLTDKKTEQKVQIIFAGGYGLLLQQQFEGSIFDSLLV 222
Cdd:TIGR00671 159 aalPKFEIA--RP-DEVLGKSTREAVQSGAVYGVLGLI-QGLLKDWKKYFKRKFAVVITGGDGKYLSAFLPFSIYDPHLT 234


                  ....
gi 1941938498 223 MKGL 226
Cdd:TIGR00671 235 VEGM 238
 
Name Accession Description Interval E-value
PRK13322 PRK13322
pantothenate kinase; Reviewed
 1-234 2.43e-79

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 238.31  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHN-------------EQAQPADINNLPWLQITEVIYACVGRSDLLNDILAQ-AASNNIICFEA 66
Cdd:PRK13322    1 MILELDCGNSRLKWRVIDNggqiiehgahldsPAELLLGLANLASLAPTRCRIVSVLSEEETARLVAIlEKRLGIPVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ 146
Cdd:PRK13322   81 KVAAELAGVRNGYEDPEQLGIDRWLALLGAFHLAKN-ACLVIDCGTAVTIDLVDADGQHLGGYICPGLYLMRDALRTHTR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 147 RVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTDKKTEqKVQIIFAGGYGLLLQQQFEGSIFDSLLVMKGL 226
Cdd:PRK13322  160 RIRYDDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGP-DFEIFLTGGDAPLLADHLPQARVVPDLVFVGL 238


                  ....*...
gi 1941938498 227 NYWHQLSK 234
Cdd:PRK13322  239 AQYCPLSP 246
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-234 2.63e-51

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 166.87  E-value: 2.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHNEQ----------AQPAD-----INNL---PWLQITEVIYACVGRSdlLNDILAQAASNnii 62
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGEllaswrlatdRRTADelaelLRQLlaaLLPDIEGVIISSVVPP--LTEALEELLRK--- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  63 CFEAKV----TKTLGDLVCAYEHVANLGIDRWLALIAGFTLYpNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMT 138
Cdd:COG1521    76 YFGVPPlvvgPGVKTGLKNAYDNPEELGADRIANAVAARELY-GGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 139 SSLTQNTQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTdKKTEQKVQIIFAGGYGLLLQQQFEGSIF- 217
Cdd:COG1521   155 EALHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIK-EELGEDPKVIATGGDAPLLAPELKTIDIv 233

                         250
                  ....*....|....*..
gi 1941938498 218 DSLLVMKGLNYWHQLSK 234
Cdd:COG1521   234 DPDLVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-229 6.76e-42

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 142.40  E-value: 6.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWHNEQ----------------AQPADINNLPWLQITEVIYACVGRSdlLNDILaQAASNNIICFEA 66
Cdd:cd24015     1 LVIDIGNTNIKLGLFDGGElvkiwrlstdkeltedELLLLLAGIELEDISGVVISSVVPS--LTEVL-EEALKKYFGISP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KV--TKTLGDLVCAYEHVANLGIDRWLALIAGFTLYpNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQN 144
Cdd:cd24015    78 LVvgPGLKLGVKIAYDNPKELGADRLANAVAAAKLY-GRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALHQR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 145 TQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIEQAKLHLTdKKTEQKVQIIFAGGYGLLLQQQFE-GSIFDSLLVM 223
Cdd:cd24015   157 TAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLK-KELGGDAKVILTGGDAKLVAPYLEpIDIYDPDLTL 235


                  ....*.
gi 1941938498 224 KGLNYW 229
Cdd:cd24015   236 KGLKLI 241
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 3-181 5.44e-39

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 133.84  E-value: 5.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWHNEQAQ-----PADINNLP-----WLQ----------ITEVIYACVGrsDLLNDILAQAASN--N 60
Cdd:pfam03309   2 LAIDIGNTNIKWGLFDGDKLVahwriSTDARRTAdelgvLLRsllrlagidpIDGVIISSVV--PPLNAALERACLKyfK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  61 IICFEAKVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSS 140
Cdd:pfam03309  80 IEPLVVGAPGIKTGLRNRYDNPKELGADRWVNAVAARELYPGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLDA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1941938498 141 LTQNTQRVFDDSKTPFTNELGKNTPNGLKNGALVATIGAIE 181
Cdd:pfam03309 160 LAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVE 200
PRK13320 PRK13320
type III pantothenate kinase;
1-228 9.92e-31

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 113.80  E-value: 9.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHNE----------QAQPADINNL--PWLQITEVIYACVGRSD--LLNDILAQAASNNIICFEA 66
Cdd:PRK13320    3 MNLVIDIGNTTTKLAVFEGDellevfvvstEGVEESLEKLlaKYPAIRDAIVSSVVPLAeeAFSALLKLLFAVLELDSET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  67 KVTKTLgdlvcAYEHVANLGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ 146
Cdd:PRK13320   83 PLPFRN-----DYDTPETLGADRLALCAGARYLFPGKNVLAIDAGTAITYDVLDSEGVYLGGLISPGLEMRFKALHEFTA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 147 RV--FDDSKTPftNELGKNTP----NGLKNGaLVATI-GAIEQAKLHLTDkkteqkVQIIFAGGYGLLLQQQFEGSIF-D 218
Cdd:PRK13320  158 RLplVTIEGPI--PLIGRSTEecirSGVVWG-CVAEIeGLIEAYKSKLPE------LLVILTGGDAPFLASRLKNTIFaD 228

                         250
                  ....*....|
gi 1941938498 219 SLLVMKGLNY 228
Cdd:PRK13320  229 EHAVLKGLNR 238
PRK13329 PRK13329
pantothenate kinase; Reviewed
 1-223 3.95e-28

pantothenate kinase; Reviewed


Pssm-ID: 183979 [Multi-domain]  Cd Length: 249  Bit Score: 107.00  E-value: 3.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLK-----------AVLWHNEQAQpADINNL---PWLQI---TEVIYACVGRSDLLNDILAQAASNNIIC 63
Cdd:PRK13329    2 TFLAIDVGNTRLKwglydaaqpgaALLAHGAEFL-AEIDRLaegAWAGLpapARVLGCNVAGDAVARRVAEQLELWDVAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  64 FEAKVTKTLGDLVCAYEHVANLGIDRWLALIAGFTLyPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQ 143
Cdd:PRK13329   81 RWVVASAAECGVRNGYDHPARLGADRWVALIGARHG-PARPCLVVMVGTAVTVDALDADGEFLGGLILPGHGLMLRALES 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 144 NTQ--RVFDDSKTPFTnelgKNTPNGLKNGALVATIGAIEQAKLHLTDkKTEQKVQIIFAGGYGLLLQQQF-------EG 214
Cdd:PRK13329  160 GTAglHVPTGEVREFP----TNTSDALTSGGTQAIAGAVERMFRHLAQ-HCGAEPECLLTGGAAWKLAPSLtvpfelvDN 234


                  ....*....
gi 1941938498 215 SIFDSLLVM 223
Cdd:PRK13329  235 LVLDGLLVI 243
PRK13328 PRK13328
type III pantothenate kinase;
1-203 3.07e-26

type III pantothenate kinase;


Pssm-ID: 237352 [Multi-domain]  Cd Length: 255  Bit Score: 102.01  E-value: 3.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKaVLWHNEQAQPADINNLP----------WLQI---TEVIYACVG---RSDLLNDILAQAASNNIICF 64
Cdd:PRK13328    2 MILLIDAGNSRIK-WAWADAGRPWVHSGAFAhgldaalapdWSALpapRGAWISNVAgpaVAARLDALLAARWPGLPVTW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  65 EAKVTKTLGdLVCAYEHVANLGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQN 144
Cdd:PRK13328   81 VRSRAAQCG-VRNGYREPAQLGSDRWAGLIGARAAFPGEHLLIATFGTATTLDALRADGRFAGGLILPGLALMMRALARH 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1941938498 145 T----------QRVFDDSKTPFTNelgkNTPNGLKNGALVATIGAIEQAKLHLTDkKTEQKVQIIFAGG 203
Cdd:PRK13328  160 TaqlptldvdaASAAAGAVAPFAD----DTPDAISAGCLAAQAGLIERAWRDLAA-RWQAPVRLVLSGG 223
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 3-226 1.38e-22

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 92.15  E-value: 1.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   3 LLIDVGNTSLKAVLWH----NEQAQPADINNLPWLQITEVIYACVGRSdlLNDILAQAA--SNN----IICFEAKVTKTL 72
Cdd:TIGR00671   2 LLIDVGNTRIVFALNSgnkvYQFWRLATNLMKTYDEHSEFLKELFGKS--LNKAFISSVvpELTeavrNMIPKIKNIKPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  73 GDLVCAYEHVAN-------LGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNT 145
Cdd:TIGR00671  80 IFFPLVYDGLPNlykspkeLGIDRVANALAAIKFYGF-NVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHALKDRA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 146 ---QRVFDDskTPfTNELGKNTPNGLKNGALVATIGAIeQAKLHLTDKKTEQKVQIIFAGGYGLLLQQQFEGSIFDSLLV 222
Cdd:TIGR00671 159 aalPKFEIA--RP-DEVLGKSTREAVQSGAVYGVLGLI-QGLLKDWKKYFKRKFAVVITGGDGKYLSAFLPFSIYDPHLT 234


                  ....
gi 1941938498 223 MKGL 226
Cdd:TIGR00671 235 VEGM 238
PRK13321 PRK13321
type III pantothenate kinase;
1-235 4.71e-21

type III pantothenate kinase;


Pssm-ID: 237349 [Multi-domain]  Cd Length: 256  Bit Score: 88.39  E-value: 4.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   1 MRLLIDVGNTSLKAVLWHNEQ-----------AQPAD-----------INNLPWLQITEVIYACVGRSdlLNDILAQAAS 58
Cdd:PRK13321    1 MLLLIDVGNTNIKLGVFDGDRllrsfrlptdkSRTSDelgilllslfrHAGLDPEDIRAVVISSVVPP--LNYSLESACK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  59 NNIIC--FEAKVTKTLGdLVCAYEHVANLGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDL 136
Cdd:PRK13321   79 RYFGIkpLFVGPGIKTG-LKIRYDNPREVGADRIVNAVAARRLYPDRNLIVVDFGTATTFDCVSGKGEYLGGAICPGILI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 137 MTSSLTQNTqrvfddSKTPF------TNELGKNTPNGLKNGALVATIGAIEQ--AKLHltdKKTEQKVQIIFAGGYGLLL 208
Cdd:PRK13321  158 SMEALSQKT------AKLPRveiakpPSAIGKSTVSSIQSGLYYGYAGLVEGivARIK---AELGGPPRVIATGGFASLI 228

                         250       260       270
                  ....*....|....*....|....*....|
gi 1941938498 209 QQqfEGSIFDSL---LVMKGLNYWHQLSKT 235
Cdd:PRK13321  229 AK--ESRCFDHVdpdLLLEGLRILYQMNRA 256
PRK13318 PRK13318
type III pantothenate kinase;
85-230 2.23e-16

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 75.56  E-value: 2.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  85 LGIDRWLALIAGFTLYPNtACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ---RVfddSKTPFTNELG 161
Cdd:PRK13318  107 VGADRIVNAVAAYELYGG-PLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISADALFQRAAklpRV---EITKPDSVIG 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1941938498 162 KNTPNGLKNGALVATIGAIEqaklHLTDK-KTE--QKVQIIFAGGYGLLLQQQFEG-SIFDSLLVMKGLNYWH 230
Cdd:PRK13318  183 KNTVEAMQSGIYYGYVGLVE----GIVKRiKEElgKDPKVIATGGLAPLFAEESDTiDIVDPDLTLKGLRLIY 251
PRK13333 PRK13333
type III pantothenate kinase;
84-226 2.67e-15

type III pantothenate kinase;


Pssm-ID: 183981 [Multi-domain]  Cd Length: 206  Bit Score: 71.88  E-value: 2.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  84 NLGIDRWLALiagftlYPNTACIVVDAGTATTIDVLSSGgLHLGGWILPGLDLMTSSLTQNTQRVfddsKTPFT-----N 158
Cdd:PRK13333   71 GLGIDRIAAC------YAIEDGVVVDAGSAITVDIMSNG-IHLGGFILPGIAAYKKAYKKISPRL----KQPFNaqislD 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1941938498 159 ELGKNTPNGLKNGALVATIGAIEQAKLhltDKKteqkvqIIFAGGYGLLLQQQFEGSIFDSLLVMKGL 226
Cdd:PRK13333  140 ALPQNTRDAISYGVIKSIILLIEKLAK---NKK------IYFTGGDGKFLSKFFPNAIYDERLVFRGM 198
PRK13331 PRK13331
pantothenate kinase; Reviewed
 84-229 9.55e-14

pantothenate kinase; Reviewed


Pssm-ID: 237353 [Multi-domain]  Cd Length: 251  Bit Score: 68.53  E-value: 9.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  84 NLGIDRWLALI-AGFTL-YPntaCIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQRVfddSKTPFTNEL- 160
Cdd:PRK13331   95 TLGIDRALALWgAGQTYgFP---CLVIDAGTALTFTGVDSDRTLVGGAILPGLGLQLRSLADKTAAL---PQVELPPPLp 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1941938498 161 ---GKNTPNGLKNGALVATIGAIEQaklHLTDKKTE-QKVQIIFAGGYGLLLQ---QQFEGSIFDSLLVMKGLNYW 229
Cdd:PRK13331  169 prwATNTQEAIQSGVIYTILAGLRD---FIEDWLSLfPDGKIVLTGGDGELLHnylQDLDPELAQRLRVDPNLIFW 241
PRK13327 PRK13327
type III pantothenate kinase;
4-236 3.19e-13

type III pantothenate kinase;


Pssm-ID: 183977 [Multi-domain]  Cd Length: 242  Bit Score: 66.78  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498   4 LIDVGNTSLKAVLWHNEQAQPADInnlpWLQITEVIYACV------GRSDLLNDILAQAASNNIIC-----FE-AKVTKT 71
Cdd:PRK13327    5 LFDLGNSRFKYAPLHGGRAGDVQA----WAHGAEAMDAAAlaalpsGRVAYVASVAAPALTQRVLAclqerFEqVRVVRT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  72 LGdlVCA-----YEHVANLGIDRWLALIAGftlYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQ 146
Cdd:PRK13327   81 AA--ACAgvriaYADPSRFGVDRFLALLGA---RGDAPVLVVGVGTALTIDLLGADGLHHGGRIAASPTTMREALHARAV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498 147 RVfddsktPFTN----ELGKNTPNGLKNGALVATIGAIEQAkLHLTDKKTEQKVQIIFAGGYGLLLQQQFEGSIFDSLLV 222
Cdd:PRK13327  156 QL------PASGgdyvEFANDTDDALTSGCDGAAVALIERS-LQHAHRSLGQPVRLLVHGGGAPPLLPLLPDAEFRPALV 228

                         250
                  ....*....|....
gi 1941938498 223 MKGLNYWHQLSKTT 236
Cdd:PRK13327  229 LDGLATWATAAAAP 242
PRK13325 PRK13325
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
79-203 1.25e-12

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;


Pssm-ID: 183976 [Multi-domain]  Cd Length: 592  Bit Score: 66.66  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  79 YEHVANLGIDRWLALIaGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQRVFDDS--KTPF 156
Cdd:PRK13325  426 YRHPEEHGSDRWFNAL-GSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNRHAgkRYPF 504

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1941938498 157 TNELGkntpNGLKNGALVATIGAIEQAKLHLTDKKTEQK-VQIIFAGG 203
Cdd:PRK13325  505 PTTTG----NAVASGMMDAVCGSVMMMHGRLKEKTGAGKpVDVIITGG 548
PRK13324 PRK13324
type III pantothenate kinase;
85-226 1.27e-09

type III pantothenate kinase;


Pssm-ID: 106284 [Multi-domain]  Cd Length: 258  Bit Score: 56.94  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1941938498  85 LGIDRWLALIAGFTLYPNTACIVVDAGTATTIDVLSSGGLHLGGWILPGLDLMTSSLTQNTQRVFDDSKTPFTNELGKNT 164
Cdd:PRK13324  106 VGADRIASCISAIADHPNKDLLIIDLGTATTFDLVTKDKKYLSGSIMPGVKLSLNALCQGASQLSSVTIVKPEVAIGYDT 185

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1941938498 165 PNGLKNGALVATIGAIEQAKLHlTDKKTEQKVQIIFAGGYGLLLQQQfegSIFDSL---LVMKGL 226
Cdd:PRK13324  186 KTNIRSGLYYGHLGALKELKRR-SVEEFGSPVYTIATGGFAGLFKEE---DIFNEIspdLILRGI 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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