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Conserved domains on  [gi|1942002587|ref|WP_197182997|]
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MULTISPECIES: cupin domain-containing protein [unclassified Pseudoalteromonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_ChrR_1 cd20303
Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 ...
 7-111 3.59e-55

Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 heterologous tandem repeats of cupin domain; This family contains bacterial anti-sigma factor such as ChrR from Marinobacter hydrocarbonoclasticus. Anti-sigma factor ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the ECF sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. This protein family likely contains two distinct homologous functional domains belonging to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380437 [Multi-domain]  Cd Length: 102  Bit Score: 171.62  E-value: 3.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587   7 FSKRVVVHSEKLEWVASPMAGVHRRPLDRVGdevARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYI 86
Cdd:cd20303     1 DSQRVVIDTRDADWVPGPVPGVERLPLHRFG---AEATALVRWAPGTRFPPHSHPGGEEILVLEGTFSDEHGDYPAGTWL 77

                          90       100
                  ....*....|....*....|....*
gi 1942002587  87 RNPPQSKHKPGSQGGCVIFVKLWQF 111
Cdd:cd20303    78 RNPHGSRHAPFSEEGCTLFVKTGHL 102
 
Name Accession Description Interval E-value
cupin_ChrR_1 cd20303
Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 ...
 7-111 3.59e-55

Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 heterologous tandem repeats of cupin domain; This family contains bacterial anti-sigma factor such as ChrR from Marinobacter hydrocarbonoclasticus. Anti-sigma factor ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the ECF sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. This protein family likely contains two distinct homologous functional domains belonging to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380437 [Multi-domain]  Cd Length: 102  Bit Score: 171.62  E-value: 3.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587   7 FSKRVVVHSEKLEWVASPMAGVHRRPLDRVGdevARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYI 86
Cdd:cd20303     1 DSQRVVIDTRDADWVPGPVPGVERLPLHRFG---AEATALVRWAPGTRFPPHSHPGGEEILVLEGTFSDEHGDYPAGTWL 77

                          90       100
                  ....*....|....*....|....*
gi 1942002587  87 RNPPQSKHKPGSQGGCVIFVKLWQF 111
Cdd:cd20303    78 RNPHGSRHAPFSEEGCTLFVKTGHL 102
Cupin_7 pfam12973
ChrR Cupin-like domain; Members of this family are part of the cupin superfamily. This family ...
 19-109 1.15e-53

ChrR Cupin-like domain; Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.


Pssm-ID: 463764 [Multi-domain]  Cd Length: 91  Bit Score: 167.42  E-value: 1.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  19 EWVASPMAGVHRRPLDRVGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKPGS 98
Cdd:pfam12973   1 PWVPSPVPGVERKPLHRDGGEKARATSLVRYAPGSRFPAHRHPGGEEILVLEGVFSDEHGDYPAGTYLRNPPGSSHAPFS 80

                          90
                  ....*....|.
gi 1942002587  99 QGGCVIFVKLW 109
Cdd:pfam12973  81 EEGCTIFVKLG 91
ChrR COG3806
Anti-sigma factor ChrR, cupin superfamily [Signal transduction mechanisms];
10-110 9.44e-47

Anti-sigma factor ChrR, cupin superfamily [Signal transduction mechanisms];


Pssm-ID: 443019  Cd Length: 157  Bit Score: 152.01  E-value: 9.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  10 RVVVHSEKLEWVaSPMAGVHRRPLDRvGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNP 89
Cdd:COG3806    37 RRAVGLDDLPWR-SPGPGVRRARLDR-GGEGGRATSLLRIAPGSAFPEHTHRGGEETLVLEGAFSDEHGDYGAGDFIRAD 114

                          90       100
                  ....*....|....*....|...
gi 1942002587  90 PQSKHKPGSQ--GGCVIFVKLWQ 110
Cdd:COG3806   115 PGSEHQPVADpdEGCICLVVLDA 137
anti_sig_ChrR TIGR02451
anti-sigma factor, putative, ChrR family; The member of this family from Rhodobacter ...
 18-103 1.03e-07

anti-sigma factor, putative, ChrR family; The member of this family from Rhodobacter sphaeroides has been shown both to form a complex with sigma(E) and to negatively regulate tetrapyrrole biosynthesis. This protein likely contains (at least) two distinct functional domains; several smaller homologs (excluded by the model) show homology only to the C-terminal, including a motif PxHxHxGxE. [Regulatory functions, Other]


Pssm-ID: 131504 [Multi-domain]  Cd Length: 215  Bit Score: 50.90  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  18 LEWVaSPMAGVHRRPLDRVGDEvARAtSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKP- 96
Cdd:TIGR02451 106 WRWR-GPGGRVSRVTLPIDDGN-ARV-RLLYIEAGQSIPQHTHKGFELTLVLHGAFSDETGVYGVGDFEEADGSVQHQPr 182


                  ....*...
gi 1942002587  97 -GSQGGCV 103
Cdd:TIGR02451 183 tVSGGDCL 190
 
Name Accession Description Interval E-value
cupin_ChrR_1 cd20303
Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 ...
 7-111 3.59e-55

Marinobacter hydrocarbonoclasticus anti-ECFsigma factor ChrR, and similar proteins; 2 heterologous tandem repeats of cupin domain; This family contains bacterial anti-sigma factor such as ChrR from Marinobacter hydrocarbonoclasticus. Anti-sigma factor ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the ECF sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. This protein family likely contains two distinct homologous functional domains belonging to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380437 [Multi-domain]  Cd Length: 102  Bit Score: 171.62  E-value: 3.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587   7 FSKRVVVHSEKLEWVASPMAGVHRRPLDRVGdevARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYI 86
Cdd:cd20303     1 DSQRVVIDTRDADWVPGPVPGVERLPLHRFG---AEATALVRWAPGTRFPPHSHPGGEEILVLEGTFSDEHGDYPAGTWL 77

                          90       100
                  ....*....|....*....|....*
gi 1942002587  87 RNPPQSKHKPGSQGGCVIFVKLWQF 111
Cdd:cd20303    78 RNPHGSRHAPFSEEGCTLFVKTGHL 102
Cupin_7 pfam12973
ChrR Cupin-like domain; Members of this family are part of the cupin superfamily. This family ...
 19-109 1.15e-53

ChrR Cupin-like domain; Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.


Pssm-ID: 463764 [Multi-domain]  Cd Length: 91  Bit Score: 167.42  E-value: 1.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  19 EWVASPMAGVHRRPLDRVGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKPGS 98
Cdd:pfam12973   1 PWVPSPVPGVERKPLHRDGGEKARATSLVRYAPGSRFPAHRHPGGEEILVLEGVFSDEHGDYPAGTYLRNPPGSSHAPFS 80

                          90
                  ....*....|.
gi 1942002587  99 QGGCVIFVKLW 109
Cdd:pfam12973  81 EEGCTIFVKLG 91
ChrR COG3806
Anti-sigma factor ChrR, cupin superfamily [Signal transduction mechanisms];
10-110 9.44e-47

Anti-sigma factor ChrR, cupin superfamily [Signal transduction mechanisms];


Pssm-ID: 443019  Cd Length: 157  Bit Score: 152.01  E-value: 9.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  10 RVVVHSEKLEWVaSPMAGVHRRPLDRvGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNP 89
Cdd:COG3806    37 RRAVGLDDLPWR-SPGPGVRRARLDR-GGEGGRATSLLRIAPGSAFPEHTHRGGEETLVLEGAFSDEHGDYGAGDFIRAD 114

                          90       100
                  ....*....|....*....|...
gi 1942002587  90 PQSKHKPGSQ--GGCVIFVKLWQ 110
Cdd:COG3806   115 PGSEHQPVADpdEGCICLVVLDA 137
cupin_DAD_ChrR cd02237
2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR, and similar proteins; ...
 28-109 1.89e-24

2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR, and similar proteins; cupin domain; This family includes the proteins 2,4'-Dihydroxyacetophenone dioxygenase (DAD) and anti-sigma factor ChrR. DAD catalyzes the oxidation of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoate and formate as part of the 4-hydroxyacetophenone catabolic pathway. The enzyme is a homotetramer containing one iron per molecule of enzyme. Anti-sigma factor ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE). Some ChrR members contain tandem repeats of two distinct homologous functional domains. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380365 [Multi-domain]  Cd Length: 82  Bit Score: 92.46  E-value: 1.89e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  28 VHRRPLDRvGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKPGS-QGGCVIFV 106
Cdd:cd02237     1 VEQRPLLI-DPNTGLITAILRMAPGARLPDHEHVGGEEFYVLDGALTDEDGTAGAGDFVREPPGSRHSAVApREGCLILV 79


                  ...
gi 1942002587 107 KLW 109
Cdd:cd02237    80 ILQ 82
cupin_ChrR cd20301
anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ...
 27-106 1.53e-08

anti-ECFsigma factor, ChrR , cupin domain; This family contains bacterial anti-sigma factor ChrR from the photosynthetic bacterium Rhodobacter sphaeroides (Rsp) and similar proteins. ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. ChrR comprises two structural and functional modules; the N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen, a potent oxidant that damages cellular biomolecules and can kill cells. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380435 [Multi-domain]  Cd Length: 161  Bit Score: 52.14  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  27 GVHRRPLDRVGDEvARAtSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKP--GSQGGCVI 104
Cdd:cd20301    79 GVRQARLDLGEGG-GRA-RLLRIAPGTRVPEHTHKGSELTLVLSGAFSDETGRYGRGDFAEADEDVEHQPvaDPDEDCIC 156


                  ..
gi 1942002587 105 FV 106
Cdd:cd20301   157 LA 158
anti_sig_ChrR TIGR02451
anti-sigma factor, putative, ChrR family; The member of this family from Rhodobacter ...
 18-103 1.03e-07

anti-sigma factor, putative, ChrR family; The member of this family from Rhodobacter sphaeroides has been shown both to form a complex with sigma(E) and to negatively regulate tetrapyrrole biosynthesis. This protein likely contains (at least) two distinct functional domains; several smaller homologs (excluded by the model) show homology only to the C-terminal, including a motif PxHxHxGxE. [Regulatory functions, Other]


Pssm-ID: 131504 [Multi-domain]  Cd Length: 215  Bit Score: 50.90  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  18 LEWVaSPMAGVHRRPLDRVGDEvARAtSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGDYPVGSYIRNPPQSKHKP- 96
Cdd:TIGR02451 106 WRWR-GPGGRVSRVTLPIDDGN-ARV-RLLYIEAGQSIPQHTHKGFELTLVLHGAFSDETGVYGVGDFEEADGSVQHQPr 182


                  ....*...
gi 1942002587  97 -GSQGGCV 103
Cdd:TIGR02451 183 tVSGGDCL 190
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
17-94 1.52e-06

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 45.78  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  17 KLEWVASPMAGVHRRPLDRVGDEVARATSIVRYAPGSEFSP-HIHTGGEEFL-VLDG--VFQDEHGDYPV--GSYIRNPP 90
Cdd:COG3837     3 NLDDLPGPEAGRRYRRLGDALGLTRLGVNLITLPPGASSSPyHAHSAEEEFVyVLEGelTLRIGGEEYVLepGDSVGFPA 82


                  ....
gi 1942002587  91 QSKH 94
Cdd:COG3837    83 GVPH 86
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
24-94 4.83e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 44.07  E-value: 4.83e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1942002587  24 PMAGVHRRPLdrVGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQDEHGD----YPVGSYIRNPPQSKH 94
Cdd:COG1917     7 ALTGVSVRVL--ADGEDELEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGeeyeLKPGDVVFIPPGVPH 79
cupin_DAD cd20302
2,4'-Dihydroxyacetophenone dioxygenase (DAD), cupin domain; 2,4'-Dihydroxyacetophenone ...
 20-105 3.57e-05

2,4'-Dihydroxyacetophenone dioxygenase (DAD), cupin domain; 2,4'-Dihydroxyacetophenone dioxygenase (DAD) catalyzes the oxidation of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoate and formate as part of the 4-hydroxyacetophenone catabolic pathway. This enzyme is a homo-tetramer containing one iron per molecule of enzyme. This enzyme is an unusual dioxygenase in that it cleaves a C-C bond in a substituent of the aromatic ring rather than within the ring itself. As a bacterial dioxygenase, DAD plays an important environmental role in the aerobic catabolism of aromatic compounds; expression of this enzyme in appropriately engineered microorganisms has the potential to use these aromatic pollutants as a carbon source and thus remove them from the environment. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380436 [Multi-domain]  Cd Length: 123  Bit Score: 42.14  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  20 WVASpMAGVHRRPLdRVGDEVARATSIVRYAPGSEFSPHIHTGGEEFLVLDGVFQ-DEHGD--YPvGSYIRNPPQSKHKP 96
Cdd:cd20302     5 WTPL-GPGVWFKPL-RFDPETGEWVVLLRVPPGGSLPRHRHTGPVHAYTLSGSWRyLEHDWvaTA-GSYVYEPAGSIHTL 81

                          90
                  ....*....|.
gi 1942002587  97 --GSQGGCVIF 105
Cdd:cd20302    82 vvPEEEETIVL 92
DUF4437 pfam14499
Domain of unknown function (DUF4437); This family of proteins is found in bacteria. Proteins ...
 3-107 7.94e-03

Domain of unknown function (DUF4437); This family of proteins is found in bacteria. Proteins in this family are typically between 152 and 283 amino acids in length.


Pssm-ID: 433994 [Multi-domain]  Cd Length: 250  Bit Score: 36.69  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587   3 IAADFSKRVVVHSEKLEWVASP---MAGVHRRPL--DRVGDEVARatSIVRYAPGSEFSPHIHTGGEEFLVLDGvfQDEH 77
Cdd:pfam14499 129 VNVDKDNIVWLDAKDIRWVKADtvqFEGAKKKFLwgDPNGGQLNG--LLIKLPAGFQGQIKIQSSNEEAVVIQG--YLDH 204

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1942002587  78 GDY--------PVGSYIRNPPQSKHKPGSQGGCVIFVK 107
Cdd:pfam14499 205 GKYrngkngtlYCGSYFGAPRHATHFVSSEDGGVIYVR 242
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 46-100 8.47e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 34.16  E-value: 8.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1942002587  46 IVRYAPGSEFSPHIHTGGEEFL-VLDG--VFQDEHGDYPV--GSYIRNPPQSKHKPGSQG 100
Cdd:pfam07883   2 LVTLPPGESSPPHRHPGEDEFFyVLEGegELTVDGEEVVLkaGDSVYFPAGVPHRFRNTG 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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