|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
22-385 |
1.98e-81 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 254.45 E-value: 1.98e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 22 AITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVH 101
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 102 TFWLLRAVQAFTGAAATVVVPGIIRHIYQKNT-AKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILL 180
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEfSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 181 FVQrYLID--IPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFN 258
Cdd:PRK11102 161 LVF-FFIPetLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 259 VMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQN 338
Cdd:PRK11102 240 IVFLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALVVGVAAFVGCVSMISSNAMAVILDEFPHM 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1949233477 339 TGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTIL 385
Cdd:PRK11102 320 AGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSIL 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
14-389 |
1.23e-80 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 252.50 E-value: 1.23e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 14 LPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLA 93
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 94 LAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNT-AKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLA 172
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAElAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 173 AYSFVILLFVQRYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFG 252
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 253 LLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHS-SLYFIVAAIVPLMMSLGIIASNADSLI 331
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGlSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1949233477 332 LMKFEQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILVQLI 389
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
10-385 |
2.36e-61 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 202.61 E-value: 2.36e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 10 TRILLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGL 89
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 90 SSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKN-TAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIF 168
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEeLSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 169 IVLAAYSFVILLFVQRyLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSE 248
Cdd:TIGR00710 163 AFLSLAGILLSALIFF-ILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 249 QLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGtALLSFSVIHsSLYFIVAAIVPLMM---SLGIIAS 325
Cdd:TIGR00710 242 SVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSA-VLLEITAIL-GLGSWAMIIGPMMFvgiGNSMISS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 326 NADSLILMKFEQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTIL 385
Cdd:TIGR00710 320 IAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVL 379
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
26-385 |
7.10e-37 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 138.10 E-value: 7.10e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 26 LAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWL 105
Cdd:PRK11043 20 LATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 106 LRAVQAFTGAAATVVVPGIIRHIYQKNTAKGMsyVSMIM---MIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFV 182
Cdd:PRK11043 100 LRFVQAVGVCSAAVIWQALVIDRYPAQKANRV--FATIMplvALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 183 QRYLIDIPIFKNDRKGLslffsSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLfKVSEQLFGLLFAFNVMAL 262
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL-----TFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQM-GYSPADIGLSYVPQTIAF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 263 MFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVI-HSSLYFIVAAIVPLMMSLG----IIASNAdsliLMKFEQ 337
Cdd:PRK11043 252 LVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLsHPSLVPLLIPFCVMAAANGaiypIVVAQA----LRPFPQ 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1949233477 338 NTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTIL 385
Cdd:PRK11043 328 ATGKAAALQNTLQLGLCFLASLLVSALISTPLLTTGSVMLSTVVLVAL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-356 |
7.56e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.33 E-value: 7.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 4 SASSFNTRILLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIG 83
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 84 LSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFS 162
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 163 LWSTIFIVLAAYSFVILLFVQRYLIDIPIFKNDRkglslFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLD 242
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARAR-----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 243 LFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFsvihSSLYFIVAAIVPLMMSLGI 322
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*
gi 1949233477 323 IASNADSLILMKF-EQNTGTATAVIGTLRFGSGAL 356
Cdd:COG2814 313 LFPLLQALVAELApPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-364 |
6.79e-27 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 110.34 E-value: 6.79e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 21 VAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEV 100
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 101 HTFWLLRAVQAFTGAAATVVVPGIIRHIYQKN-TAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVIL 179
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGErRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 180 LFVQRYlidipifkndrkglslffssykvvlsnphaRADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNV 259
Cdd:cd17321 165 LLARTF------------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 260 MALMFGNFLNTRVVPRIGSRKMLYYGLICGFIsGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQN- 338
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV-GLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEk 293
|
330 340
....*....|....*....|....*.
gi 1949233477 339 TGTATAVIGTLRFGSGALVGPILAVM 364
Cdd:cd17321 294 AGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-389 |
1.03e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 104.19 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 14 LPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLA 93
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 94 LAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQ-KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSlWSTIFIVLA 172
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 173 AYSFVILLFVqrYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFG 252
Cdd:cd17474 160 ALIPVAFLAI--LFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 253 LLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSvihSSLYFIVAAIVPLMMSLGIIASNADSLIL 332
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949233477 333 MKF-EQNTGTATAVIGTLRFGsGALVGPILA---VMHAQSAVPFSSLMFSAVVLTILVQLI 389
Cdd:cd17474 315 ELApEEERGTASSLYNFVRFL-GQAVGPLLFgllLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-364 |
3.23e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 102.63 E-value: 3.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 38 IANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAA 117
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 118 TVVVPGIIRHIYQKNT-AKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYLidiPIFKNDR 196
Cdd:cd17324 105 WAIAAAYAADLVPPEKrGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL---PSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 197 KGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRI 276
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 277 GSRKMlyygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNTGTATAVIGTLRFGSGAL 356
Cdd:cd17324 262 GRRAL----LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGAL 337
|
....*...
gi 1949233477 357 VGPILAVM 364
Cdd:cd17324 338 GAALGGLV 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
13-385 |
7.86e-23 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 98.83 E-value: 7.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 13 LLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSL 92
Cdd:PRK11652 9 LLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 93 ALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQ-KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVL 171
Cdd:PRK11652 89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEgTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 172 AAYSFVILLFVQRYLIDIPIFKNDRKGLslfFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLF 251
Cdd:PRK11652 169 LLLGAGVTFSMARWMPETRPADARRTRV---LASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLSSMTV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 252 GLLFAFNVMALMFGNFLNTRVVPRIgsRKMLYYGLICGFISGTALLS---FSV-------IHSSLYFIVAaivplmmslG 321
Cdd:PRK11652 246 SILFILPIPAAFFGAWFAGRPNKRF--STLMWQSVICCLLAGLLMWIpgwFGVmnvwtllVPAALFFFGA---------G 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1949233477 322 IIASNADSLILMKFEQNTGTATAVIGTLR-FGSGALVGpILAVMHAQSAVPFSSLMFSAVVLTIL 385
Cdd:PRK11652 315 MLFPLATSGAMEPFPYLAGTAGALLGGLQnIGSGLAAL-LSAMLPQTGQFSLGLLMTLMGLLILL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-393 |
3.37e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 3.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAF 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 97 TTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYS 175
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 176 FVILLFVQRYLIDIPIFKNDRKGLS-LFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLL 254
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 255 FAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLIcgfISGTALLSFSVIHS-SLYFIVAAIVPLMMSLGIIASNADSLILM 333
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLL---LSAVALLLLPLATSfWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 334 KfEQNTGTATAVIGTLrFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILVQLIHYFK 393
Cdd:cd17325 318 P-PEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
20-181 |
3.62e-20 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 91.24 E-value: 3.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 20 IVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTE 99
Cdd:PRK10473 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAET 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 100 VHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVI 178
Cdd:PRK10473 91 SSLFLAGRFLQGIGAGCCYVVAFAILRDTLdDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILV 170
|
...
gi 1949233477 179 LLF 181
Cdd:PRK10473 171 LLL 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-356 |
7.12e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.78 E-value: 7.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAM-LVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALA 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 96 FTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQK-NTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAY 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 175 SFV--ILLFVQRYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARAdILSSMFVSFGFFCFLTSVPyIYLDLFKVSEQLFG 252
Cdd:pfam07690 161 SLLaaVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 253 LLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLIL 332
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 1949233477 333 MKFEQNTGTATAVIGTLRFGSGAL 356
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGAL 342
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
24-382 |
7.22e-20 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 90.38 E-value: 7.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 24 TPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTF 103
Cdd:PRK15402 25 TYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 104 WLLRAVQAFTGAAATVVVPGIIRHIYQKNTA-KGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFV 182
Cdd:PRK15402 105 TLLRFLQGIGLCFIGAVGYAAIQESFEEADAiKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 183 QRYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMAL 262
Cdd:PRK15402 185 WRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILISGEQLSSYEYGLLQVPVFGAL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 263 MFGNFLNTRVVPRIGSRKMLYYGLICgFISGTALLSFSVIHSSL--YFIVAAIVPLMMSLGIIASNADSLILMKFEQNTG 340
Cdd:PRK15402 265 IAGNLTLARLTSRRPLRSLIRMGLWP-MVAGLLLAALATVISSHayLWLTAGLSLYAFGIGLANAGLYRLTLFSSDVSKG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1949233477 341 TATAVIGTLRFGSGALVGPILAVMHAQsavpFSSLMFSAVVL 382
Cdd:PRK15402 344 TVSAAMGMLSMLIFTVGIELSKHAYLG----GGNGLFNLFNL 381
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
34-362 |
8.09e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 89.94 E-value: 8.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFT 113
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 114 GAAATVVVPGIIRHIYQKNT-AKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAysFVILLFVQRYLIDIPIF 192
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKrGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP--IGILALLLAPLLDLRLF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 193 KNDRKGLSlffssykvvlsnpharadILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRV 272
Cdd:cd17503 176 KDRNFTLG------------------LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 273 VPRIGSRKMLYYGLICGFIsGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFE-QNTGTATAVIGTLRF 351
Cdd:cd17503 238 LDKFGPRLLLLAGLLLLAL-GTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPpEQIGDATALFNTIRQ 316
|
330
....*....|.
gi 1949233477 352 GSGALVGPILA 362
Cdd:cd17503 317 LGGSIGTALLA 327
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-396 |
1.08e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.86 E-value: 1.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 11 RILLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLS 90
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 91 SLALAFTTEVHTFWLLRAVQAFTGAAA-TVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFI 169
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 170 VLAAYSFVILLFVQRYLIDIPIFKNDRKGLSlfFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQ 249
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKAS--LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 250 LFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLyygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADS 329
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVL---LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1949233477 330 LILMKFE-QNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILVQLIHYFKDKK 396
Cdd:COG2223 319 LVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-184 |
1.31e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 85.25 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 1 MSASASSFNTRILLPLLASIVA--ITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRK 78
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGtfLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 79 LARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNT-AKGMSYVSMIMMIAPLLAPSIGSV 157
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180
....*....|....*....|....*..
gi 1949233477 158 ILGFSLWSTIFIVLAAYSFVILLFVQR 184
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
16-280 |
5.06e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 84.93 E-value: 5.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 16 LLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALA 95
Cdd:cd17323 3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 96 FTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNTA-KGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAY 174
Cdd:cd17323 83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERgKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 175 SFVILLFVqryLIDIPIfkndrkglslffssykvvlsnpharaDILSSMFVSFGF---FCFLTSVPYIYLDLFKVSEQLF 251
Cdd:cd17323 163 SGFCLILI---FLFLPI--------------------------VLLLGLYVGLVYailYLFLTAFPYVFGEVYGFSPGEV 213
|
250 260
....*....|....*....|....*....
gi 1949233477 252 GLLFAFNVMALMFGNFLNTRVVPRIGSRK 280
Cdd:cd17323 214 GLMYLPIGIGALIGSIIGGRLSDYYYRRL 242
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-386 |
8.99e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.14 E-value: 8.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 6 SSFNTRILLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLS 85
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 86 LFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSL-- 163
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLsl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 164 -WSTIFIVLAAYSFVILLFVqrYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLD 242
Cdd:COG0738 162 sWHLPYLILAVLLLLLALLF--LRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 243 LFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIV------AAIVPL 316
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLAlvglglSLMFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 317 MMSLGIiasnadslilMKFEQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:COG0738 320 IFSLAL----------DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-386 |
3.62e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 79.14 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 3 ASASSFNTRILLPLLASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARI 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 83 GLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGF 161
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 162 SLWSTIFIVLAAYSFVILLFVQRYLidipifkndrkglslffssykvvlsnpharadILSSMFVSFGFFCFLTSVPYIYL 241
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL--------------------------------ALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 242 DLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLG 321
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV--LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1949233477 322 IIASNADSLILMKF-EQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:COG2271 287 GAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAAL 352
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-382 |
1.40e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.47 E-value: 1.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAF 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 97 TTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVIL-----GFSLWSTIFIV 170
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILAsslgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 171 LAAYSFVILLFVQRYLIDIPIFKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQL 250
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 251 FGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSL 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 331 ILmkFEQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVL 382
Cdd:cd06174 321 LF--PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-374 |
5.94e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 75.69 E-value: 5.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAF 96
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 97 TTEVHTFWLLRAVQAFTGAaatvVVP---GIIRHIYQKN-TAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLA 172
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA----VFPlafALVREEFPPErVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 173 AysFVILLFVQRYLIDIPIFKNDRKGLSLffssykvvlsnpharadiLSSMFVSFGFFCFLTSVPYIY-----LDLFKVS 247
Cdd:cd17504 157 P--VAVLLAALVPLIDLRLLRRRNVLLAN------------------ITALLAGFGMFMVFQLLPQLLqlptpTGFGLGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 248 EQLFGLLFAFNVMALMFGnFLNTRVVPRIGSRKMLYYGLIcgfISGTALLSFSVIHSSLYFIVAAIVPLMMSLGII-ASN 326
Cdd:cd17504 217 TEAGLLLLPGALVMLIAG-PLAGRLIARVGPRRVLLIGLV---ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAfASL 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1949233477 327 ADSLILMKFEQNTGTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSS 374
Cdd:cd17504 293 PNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITS 340
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-393 |
2.43e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.78 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 26 LAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWL 105
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 106 LRAVQAF-TGAAATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQR 184
Cdd:cd17489 90 LRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 185 YLIDIPIFKNDRKGLSLFFSSYKVVLSNPHAradiLSSMFVSFGFFCFLTSVPYIYLDLFKVSeqlFGLLFAFNVMALMF 264
Cdd:cd17489 170 VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPA----LILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 265 GNFLNTRVVPRIGSRKMLYYGLICGFIsgtALLSFSVIHSSLYFIVAAIVpLMMSLGIIASNADSLILMKFEQNT-GTAT 343
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIPGLLLLAL---GLLLLSFAGSPWMLLLAAVL-YGLGFGLLFPALQALAVDLVPPHRrGAAN 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1949233477 344 AVIGTLrFGSGALVGPILAVMHAQSAvPFSSLMFSAVVLTILVQLIHYFK 393
Cdd:cd17489 319 GTFFIF-FDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFL 366
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
54-173 |
7.50e-14 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 68.06 E-value: 7.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMLFFGPIA----DQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY 129
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1949233477 130 QKNT-AKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAA 173
Cdd:TIGR00880 81 PPEErGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAI 125
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
26-180 |
1.80e-12 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 68.31 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 26 LAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWL 105
Cdd:PRK15403 30 LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLI 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1949233477 106 LRAVQAFTGA-AATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILL 180
Cdd:PRK15403 110 ARFIQGTSICfIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFV 185
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
44-386 |
5.42e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.82 E-value: 5.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 44 TSMPNVQISL--SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVV 121
Cdd:COG2807 48 LGLSATQAGLltTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 122 PGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVqrylidIPIFKNDRKG--L 199
Cdd:COG2807 128 PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLW------LPLLRRRPAAaaA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 200 SLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLfKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSR 279
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 280 KMLYYGLICGFISGTALLSFsvihSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNTGTATAVIGTLRFGS-GALVG 358
Cdd:COG2807 281 RPLLLLLGLLGLAGLLGLLL----APGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYlLAALG 356
|
330 340 350
....*....|....*....|....*....|..
gi 1949233477 359 PILA-VMHAQS---AVPFSSLMFSAVVLTILV 386
Cdd:COG2807 357 PLLVgALHDATgswTAALLLLAALAVLMLVAG 388
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-387 |
3.71e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.17 E-value: 3.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 30 MYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARI--GLSLFGLSSLALAFTTEVHTFWLLR 107
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 108 AVQAFTGAAATVVVPG----IIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFI---VLAAYSFVILL 180
Cdd:cd06173 97 VLAFLLGIASAFFGPArqalLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinaLSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 181 FVQRYLIDIPIFKNDRKGLSLFFSSYKVVLSNPhARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVM 260
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPL-LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 261 ALMFGNFLNTRVVPRIGSRKMLyygLICGFISGTALLSFSVIHsSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNT- 339
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLL---LIGALLLGLALLVLGLSP-SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELr 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 340 ----GTATAVIGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILVQ 387
Cdd:cd06173 332 grvfSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
49-386 |
5.50e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 5.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 49 VQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHI 128
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 129 YQ-KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSlWSTIFIVLAAySFVILLFVqryLIDIPIFKNDRKGLSLFFSSYK 207
Cdd:cd17473 117 FEgEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLVYLL-ALPVLILV---LLFLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 208 VVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLI 287
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 288 CGFIsGTALLSFSvihSSLYFIVAAIVPLMMSLGIIASNADSLILMKF-EQNTGTATAVIGTLRFGSGALVGPILAVMHA 366
Cdd:cd17473 272 LMAL-GFLLLALA---SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVN 347
|
330 340
....*....|....*....|
gi 1949233477 367 QSAVPFSSLMFSAVVLTILV 386
Cdd:cd17473 348 LTGGLSGAFLILGVLALVLA 367
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
38-361 |
7.78e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.86 E-value: 7.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 38 IANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFtteVHTFWLLRAVQAFTGAAA 117
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL---VGSYPVLLVLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 118 TVVVPGIIRHIY------QKNTAkgMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYLIDIPI 191
Cdd:cd17475 99 GSVQPGGGRAIMrwfpprERGLA--MGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 192 FKNDRKGLSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTR 271
Cdd:cd17475 177 ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 272 VVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLIL---MKFEQNTGTATAVIGT 348
Cdd:cd17475 257 VSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLvaeSAGPEQAGTALGLANT 336
|
330
....*....|...
gi 1949233477 349 LRFgSGALVGPIL 361
Cdd:cd17475 337 INF-IGIAIGPPL 348
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
17-386 |
2.65e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 55.30 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAMLVIANDLNTSMPN-VQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALA 95
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTlIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 96 FTTEVHTFWLLRAVQAfTGAAATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYS 175
Cdd:cd17472 81 YATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 176 FVILLFVQRYLIDIPIFKNDRKGLSLFFSSykvVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLF---- 251
Cdd:cd17472 160 LVSLLILLFFVPDPPKIVQISEKEKKKLKK---LLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWkvyl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 252 -GLLFAFNVMalmfgnFLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVihSSLYFIVAAIVPLMMSLGIIASNADSL 330
Cdd:cd17472 237 pAILIGFILM------VPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAA--TSLWLLIIGLIIFFIGFNLLEALLPSL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949233477 331 IlMKFEQNT--GTATAVIGTLRF-GS--GALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:cd17472 309 V-SKIAPKEyrGTAMGIYNTSQFlGSflGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
34-378 |
2.93e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 54.88 E-value: 2.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNtSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFT 113
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 114 GAAATVVVPGIIRHIYQ-KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFivlaaysfvillfvqryLIDIPIF 192
Cdd:cd17502 97 GGGLMSLAFIIIADLVPpRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF-----------------YINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 193 kndrkGLSLFFSSYKVVLSnpharadiLSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRV 272
Cdd:cd17502 160 -----GLALALLRTILLSS--------IFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 273 VPRIGS-RKMLYYGLICGFIsGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQN-TGTATAVIGTLR 350
Cdd:cd17502 227 ISKTGRyKPLIVIGTILMSV-GAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPAdVGVATATNTFFR 305
|
330 340
....*....|....*....|....*...
gi 1949233477 351 FGSGALVGPILAVMHAQSAVPFSSLMFS 378
Cdd:cd17502 306 SLGGTLGVAITDVFLVALALAALAFLLS 333
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-314 |
3.53e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.93 E-value: 3.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 53 LSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFtteVHTFWLLRAVQAFTGAAATVVVPG----IIRHI 128
Cdd:cd17329 41 LALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF---AHSPWLFAIALVLTGFGGGLFEPAseamIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 129 YQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLwSTIFIVLAAySFVILLFVQRYLIDIPIFKNDRKGLSLFFSSYKV 208
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAV-LFLLAALVLLFLLPETRPKRRAAEKTEILRGYKI 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 209 VLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLIC 288
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILL 275
|
250 260
....*....|....*....|....*.
gi 1949233477 289 gFISGTALLSFSviHSSLYFIVAAIV 314
Cdd:cd17329 276 -FAIGFAVLAFA--NTLAVLILAMIV 298
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
134-386 |
4.13e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 4.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 134 AKGMSYVSMIMMIAPLLAPSIGSVILGFSL------WSTIFIVLAAYSFVILLFVQRYLIDIPIFKNDRKGlslFFSSYK 207
Cdd:COG2211 146 TRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS---LKESLK 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 208 VVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLI 287
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 288 CGFISGTALLSFSVIHSSLYFIVAAIV------PLMMSLGIIASNADSLILMKFEQNTGTATAVIGTLR----FGSGALV 357
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAgiglgaILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIklgqALAGALA 382
|
250 260
....*....|....*....|....*....
gi 1949233477 358 GPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:COG2211 383 GLLLALFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-386 |
7.07e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 53.74 E-value: 7.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDM---YLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLA 93
Cdd:cd17330 1 LFLVVFLDALGFGIvfpVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 94 LAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAA 173
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 174 YSFVILLFVQRYLidipifkndrkglslffssykvvlsnPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGL 253
Cdd:cd17330 161 LALLNLVLVLFFL--------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 254 LFAFN-VMALMFGNFLNTRVVPRIGSRKMLYYGLICGFIsGTALLSFsvihSSLYFIVAAIVPLMMSLGIIASNADSLIL 332
Cdd:cd17330 215 LLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII-GLLLLPF----ASSVPLLVLAAAILAFGTGIVFPALSALL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1949233477 333 MKF--EQNTGTATAVIGTLRfGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:cd17330 290 SKSvpSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
53-362 |
1.65e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.74 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 53 LSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTevhTFWLLRAVQAFTGAAATVVVPGIIRHIYQKN 132
Cdd:TIGR00895 58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT---NVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 133 TAKGMSYVSMIMMIAPLLAPSIGSVILGFSL----WSTIFIVLAAYSFVILLFVQRYL---IDIPIFKNDRKGLSLFF-- 203
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpvfgWRSLFYVGGIAPLLLLLLLMRFLpesIDFLVSKRPETVRRIVNai 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 204 -----------------------SSYKVVLSNPHARADIL---SSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAF 257
Cdd:TIGR00895 215 apqmqaeaqsalpeqkstqgtkrSVFKALFQGKTARITVLlwlLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 258 NvMALMFGNFLNTRVVPRIGSRKMLYYGLICGFIsgtALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQ 337
Cdd:TIGR00895 295 N-FGGVIGSIIFGWLADRLGPRVTALLLLLGAVF---AVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
|
330 340
....*....|....*....|....*.
gi 1949233477 338 NTGTATAV-IGTLRFGSGalVGPILA 362
Cdd:TIGR00895 371 IRATGVGWaIGIGRLGAI--IGPILA 394
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
54-389 |
2.78e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.30 E-value: 2.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQA--FTG--AAATVVVPGIIRHIY 129
Cdd:cd17371 41 TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGlgFGGewAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 130 QKNTAKG-MSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVIlLFVQRYLIDIPIFKNDRKGLSLFFSSYKV 208
Cdd:cd17371 121 RGKALGYvQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLV-LFIRRFVKEPPQWQAARAARRHFADRPSL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 209 --VLSNPHARADILSSMFVS---FGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLY 283
Cdd:cd17371 200 reLFSPPLLRTTLLASLLATgalGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 284 YGLICGFISgtaLLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNTGtATAVIGTLRFG-SGALVGPILA 362
Cdd:cd17371 280 LFALGSAIS---ILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVR-ATAQGFCYNVGrIIGALFPFLV 355
|
330 340
....*....|....*....|....*...
gi 1949233477 363 VMHAQS-AVPFSSLMFSAVVLTILVQLI 389
Cdd:cd17371 356 GFLATSgSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
34-314 |
1.42e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNTSMPNVQISL--SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQ- 110
Cdd:cd17316 21 VAPVLAAEFSLGLSLLQTGLlfAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQg 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 111 AFTGAAATVVVPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSL----WSTIFIVLAAYSFVILLFvqryl 186
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALLL----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 187 idipifkndRKGLSLFfssykvvlsnpharadILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGN 266
Cdd:cd17316 176 ---------RRRTLLL----------------ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGA 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1949233477 267 FLNTRVVPRIGSRKMLYYGLICGFISGTALLSFSVIHSSLYFIVAAIV 314
Cdd:cd17316 231 LIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFIL 278
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-386 |
2.98e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.86 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 35 MLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFglsSLALAFTTEVHTFWLLRAVQAFTG 114
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLI---SLALALIFATPSIYLFVVLMFLAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 115 AAATVVVPG---IIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSL-WSTIFIVLAAYSFVILLFVQRYLIDIP 190
Cdd:cd17333 96 LGAGILDTGantFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELsWSWAYLIIGLIYLLLAILILLTLFPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 191 IFKNDRKGLSLFFSSYKV-VLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLN 269
Cdd:cd17333 176 PSARNPQQSVGAFSASASrLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 270 TRVVPRIGSRKMLYYGLICGFISGTALLsfsvIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNTGTATAVIGTL 349
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILL----LAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAA 331
|
330 340 350
....*....|....*....|....*....|....*..
gi 1949233477 350 RFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFV 368
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-361 |
3.30e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 3.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 26 LAIDMY---LPAML-VIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTevh 101
Cdd:cd17478 6 FLNDFYqgfLPALLpLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 102 TFWLLRAVQAFTGAAATVVVP---GIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVIL--GFSLWSTIFIVLAAYSF 176
Cdd:cd17478 83 NYWLLLLLVALAGIGSAAFHPegaRLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALValFGGLGLLILLIIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 177 VILLFvqRYLIDIPIFKNDRKGLSLFFSSYKVVLsnPHARADILSSMFVSFGFFCFLTSVPYIYLDLFkVSEQLFGLLFA 256
Cdd:cd17478 163 ALLLL--RLRPLKKPEAKKAAAKSSARSTLKGVW--RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 257 FNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGFISgTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLIlmkfE 336
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPF-LLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL----P 312
|
330 340
....*....|....*....|....*
gi 1949233477 337 QNTGTATAVIGTLRFGSGALVGPIL 361
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVL 337
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
53-109 |
7.73e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 7.73e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1949233477 53 LSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAV 109
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFL 96
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
51-176 |
1.74e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.89 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 51 ISLSIYLaGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAF-TGAAATVVVPGIIRHIY 129
Cdd:TIGR01299 207 LGLIVYL-GMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFgIGGAIPIVFSYFAEFLA 285
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1949233477 130 QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWStiFIVLAAYSF 176
Cdd:TIGR01299 286 QEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWS--FQMGSAYQF 330
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
17-386 |
3.10e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 17 LASIVAITPLAIDMYLPAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAF 96
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 97 TTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY-QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLwsTIFIVLAAYS 175
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAtNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 176 FVILLFVQRYLIDIPIFKNDRKGlslffSSYKVVLSNPHARADILSSMFVSFGFFCFLTsvpyIYLDLFKVSEQLFGLLF 255
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESI-----SLRRLLRIAPLALLGAFVAGFLEGAFYSLLP----LYGLRLGLSVAQAALLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 256 AFNVMALMFGNFLNTRVVPRIGSRKMLyygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKF 335
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLADRFDRRRVL---LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 336 EQN-TGTATAVIGTLrFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:cd17477 307 PGDeLVAANAALLLL-YGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-120 |
3.13e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 45.65 E-value: 3.13e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 49 VQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVV 120
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTV 98
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
33-364 |
7.94e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 7.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 33 PAMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTtevHTFWLLRAVQAF 112
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS---TSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 113 TGAAATVVVPGIIRHIY----QKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYLID 188
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGnwfsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 189 IPIfkndrkglslffssYKVVLSnpharadiLSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFL 268
Cdd:cd17312 181 SPP--------------YVWVLS--------LAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTIL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 269 NTRVVPRIGSRKMLYYGLICGFISGTALLSFSVI-HSSLYFIVAAIVPLMMSLGIIA--SNADSLILMKfEQNTGTATAV 345
Cdd:cd17312 239 AGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPINliGGAAAQDIGR-KEAAGTATGF 317
|
330
....*....|....*....
gi 1949233477 346 IGTLRFGSGALVGPILAVM 364
Cdd:cd17312 318 VGLFGYLGASLAGLPLGYI 336
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
51-344 |
1.01e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.08 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 51 ISLSIYLAGYAL-GML---FFGPIADQIG-RRKLARIGLSLFGLSSLALAFTtevHTFWLLRAVQAFTGAAATVVVPGII 125
Cdd:cd17471 32 LQIGIFMTLSALsGIVvsqWLGRLSDRGGdRKPLILLALLAGALGYLLFAFL---RNYWVLLLVGVVLLSLGAAAFPQLF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 126 RHIYQ-------KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYLIDIPIfkndRKG 198
Cdd:cd17471 109 ALAREyadrssgRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKP----PAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 199 LSLFFSSYKVVLSNPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFN-----VMALMFGnflntRVV 273
Cdd:cd17471 185 KATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAaaleiPIMLLAG-----LLA 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949233477 274 PRIGSRKMlyygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNTGTATA 344
Cdd:cd17471 260 KRFGKRRL----LLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATT 326
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
34-178 |
1.91e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.02 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQaft 113
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQ--- 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1949233477 114 GAAATVVVP---GIIRHIYQKNTAKGMSyVSMIMMIAPL---LAPSIGSVILGFSLWSTIFIVLAAYSFVI 178
Cdd:cd17476 97 GLGPAFLLPnamALLGRTYPPGPRKNIV-FSLFGATAPLgfaLGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-385 |
2.33e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFT 113
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 114 GAAATvvvPGIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSL----WSTIFIVLAAYSFVILLFVQRYLidi 189
Cdd:cd17319 105 EAGFF---PGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLllfgWRWAFIIEGLLGLLLAVLWWFYL--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 190 pifkndrkglslffssykvvlsnPHARADILSSMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLN 269
Cdd:cd17319 179 -----------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 270 TRVVPRI--GSRKMLyygLICGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNT-GTATAVI 346
Cdd:cd17319 236 GRLSDRLlrGARRLV---IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAaATAGGLI 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 1949233477 347 GTLrFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTIL 385
Cdd:cd17319 313 NSG-GNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
54-186 |
3.17e-04 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 42.79 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMlffGPIADQIGRRKLARIGLSLFGLSSLALAFTtevHTFWLLRAVQAFTGAAATVVVPGI---IRHIY- 129
Cdd:PRK14995 51 SLVMAGMVLPM---GALGDRIGFKRLLMLGGTLFGLASLAAAFS---PTASWLIATRALLAIGAAMIVPATlagIRATFt 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 130 ---QKNTAKGMSyvSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYL 186
Cdd:PRK14995 125 eekQRNMALGVW--AAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
62-291 |
4.04e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.19 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 62 LGMLFFGPIADQIGRRKLARIgLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVP----GIIRHIYQKNTAKG- 136
Cdd:cd17335 47 LSAPLWGALADRFGKRKALLL-LSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVPlvdsITLQYLGEERERYGk 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 137 ---MSYVSMIMMiAPLLAPSIGSVILGFSLwSTIFIVLAAYSFVILLFVQRylidIPIFKNDRKGlSLFFSSYKVVLSNP 213
Cdd:cd17335 126 qrlWGSIGFGIA-ALLVGILIDRSSTYKNY-TIAFYVFAVLMLLALLLALK----FPFRPKHPEP-NENTGGLLALLRNP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 214 HARADILSSMFVSFG---FFCFLtsvpYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNTRVVPRIGSRKMLYYGLICGF 290
Cdd:cd17335 199 RVLAFLLVAFLMGFGhglIYSFL----FWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYV 274
|
.
gi 1949233477 291 I 291
Cdd:cd17335 275 V 275
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
55-319 |
4.25e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.24 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 55 IYLAGYALGMLFFGPI----ADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQ 130
Cdd:cd17388 42 VLLALYALMQFIFAPIlgalSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 131 KNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLwSTIFIVLAAYSFVILLFVqrYLIDIPIFKNDRKGLSLFFSSYKVVL 210
Cdd:cd17388 122 EQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-RAPFLVAAGLNGLNFLLG--LFVLPESLPPERRRAFRWRRANPFGS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 211 SNPHARADILSSMFVSFGFFCFLTSVP-----YIYLDLFKVSEQLFGL-LFAFNVMALMFGNFLNTRVVPRIGSRKMLYY 284
Cdd:cd17388 199 LRWLTGFPGLLGLLAVFFLIQLIGQVPattwvLFTEDRFDWSPTMVGLsLAVFGLLHALFQAFVTGPIAKRLGEKRAILL 278
|
250 260 270
....*....|....*....|....*....|....*
gi 1949233477 285 GLIcgfISGTALLSFSVIHSSlYFIVAAIVPLMMS 319
Cdd:cd17388 279 GLA---ADALGFLLLAFATQG-WMVFPILILLALG 309
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-182 |
5.47e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 16 LLASIVAITPLAIDMYLPAMLV-IANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLAL 94
Cdd:cd17355 6 AVTFLILILSWGIRYYFGVFIIpIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 95 AFTTEVHTFWLLRAVQAFTGAAATVVVP--GIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLA 172
Cdd:cd17355 86 ALATSLWQLYLLWGLLGGGGAGTLAAVAfaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLA 165
|
170
....*....|
gi 1949233477 173 AYSFVILLFV 182
Cdd:cd17355 166 LLALLVLVPV 175
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
53-186 |
6.47e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.39 E-value: 6.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 53 LSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEvHTFWLLRAVQAFTGAAATVVVPGII----RHI 128
Cdd:cd17380 40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY-SSLPLLILSRILLGLGEGVHFPSMTslfsRWV 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1949233477 129 YQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQRYL 186
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL 176
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
33-122 |
7.47e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.41 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 33 PAMLVIANDLNTSMPNVQISL--SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQ 110
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLQGLvvSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90
....*....|..
gi 1949233477 111 AFTGAAATVVVP 122
Cdd:cd17315 98 GLGVGLASVLVP 109
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
59-181 |
1.04e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 59 GYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIYQKNTAKGMS 138
Cdd:cd17358 53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALG 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1949233477 139 YVSMIMM-IAPLLAPSIGSVIlgfsLWSTIFIVLAAYS--FVILLF 181
Cdd:cd17358 133 SLNQLLVnIGILLGYVLGSFL----PWRTLALIGAIPPvvFLILLF 174
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
34-122 |
1.15e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 34 AMLVIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFT 113
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
....*....
gi 1949233477 114 GAAATVVVP 122
Cdd:cd17359 103 VGGASALVP 111
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
54-176 |
1.28e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 40.67 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAF-TGAAATVVVPGIIRHIYQKN 132
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFgIGGAVPTVFSYFAEVLAREK 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1949233477 133 TAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWStiFIVLAAYSF 176
Cdd:cd17440 121 RGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWS--FSMGSAYQF 162
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
65-386 |
1.64e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.68 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 65 LFFGP---IADQIGRR------KLARIGLSLFGLSSLALAFttevhtFWLLRAVQAFTGAAATVVVP---GIIRHIYQK- 131
Cdd:PRK08633 62 LLSSPagfLADKFSKNrvirivKLFEVGLTLLIVLAYYLGW------FWLAFAVTFLLGAQSAIYSPakyGIIPELVGKe 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 132 NTAKGMSYVSMIMMIAPLLAPSIGSVI-----------LGFSLWsTIFIVLAAYSFVILLFVQRylidIPIFK-----ND 195
Cdd:PRK08633 136 NLSRANGLLEAFTIVAILAGTALFSFLfesvngntpseILGRIA-PAGLVLLAVAVLGLIFAYR----LPKVPaaapeVF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 196 RKGLSLFFSSY----KVVLSNPHARADILS-SMFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALMFGNFLNT 270
Cdd:PRK08633 211 DKKKYLFPKLLwrnlKLLRSDRVLWLAIIGlSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIGSLLAG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 271 RVvprigSRKMLYYGLI-CGFISGTALLSFSVIHSSLYFIVAAIVPLMMSLGIIASNADSLILMKFEQNT-GT---ATAV 345
Cdd:PRK08633 291 RL-----SGRHIELGLVpLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKElGKvlaANNF 365
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1949233477 346 IGTLRFGSGALVGPILAVMHAQSAVPFSSLMFSAVVLTILV 386
Cdd:PRK08633 366 LQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLYT 406
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
38-386 |
1.66e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 38 IANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTGAAA 117
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 118 --TVVVPGIIRHIYQKntaKGMS--YVSMIMMIAPLLAPSIGSVILGFSLWSTIFIVLAAYSFVILLFVQrYLIDIPIFK 193
Cdd:cd17353 109 gyITPVSTAVKWFPDK---RGLAtgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGA-FLIRDPPKG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 194 NDRKGLSLFFSSYKVVLSNPHARADILSS----MFVSFGFFCFLTSVPYIYLDLFKVSEQLFGLLFAFNVMALM-----F 264
Cdd:cd17353 185 WVPPGVDPLANNAENSPRDYTPREMLRTPtfwlLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILsifngG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 265 GNFLNTRVVPRIGSRKMLYYGLICGFIsGTALLSFSVIHSSLYFIVAAIVPLMM--SLGIIASnadslILMKF--EQNTG 340
Cdd:cd17353 265 GRPFWGWLSDKIGRKNTLSIAFLIQGV-AMFLLPFIGSVAVLFVLGVALIGFCYggGFALFPA-----LTADFfgTKNAG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 341 TATAVIGTlRFGSGALVGPILAVMHAQSA------VPFSSLMFSAVVLTILV 386
Cdd:cd17353 339 TNYGLLYT-AKGVGGLIGPIIAAYVLYTGgynaafIIAAALSLVALALALLL 389
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
54-181 |
1.67e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 40.35 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQAFTgaaatvvVPGIIRHIYQKNT 133
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFA-------VSGISINTLILGT 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1949233477 134 AKGMSYVSMIMMIAPLLAPSIGSVILG-----FSLWSTIFIVLAAYSFVILLF 181
Cdd:cd17374 115 EWTTPRHRALAITLTSCFFSIGQMLLAglayaIRDWRLLQLVVSVPFFLFFLY 167
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-180 |
1.83e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 12 ILLPLLASIVAITPLAIDMYLPAMLVIANDLntSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSS 91
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGL--SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 92 --LALAFTTEVHTFWLLRAVQAFTGAAATVVVPGIIRHIY---QKNTAKGMSYV--SMIMMIAPLLAPSIGSVILGFSLW 164
Cdd:cd17316 258 lpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFpteVRATGVGLSYNlgRLGGGGAPPLIALLLASTGGTGVP 337
|
170
....*....|....*.
gi 1949233477 165 STIFIVLAAYSFVILL 180
Cdd:cd17316 338 ALILALLAIVALIVAL 353
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
56-125 |
2.43e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 39.61 E-value: 2.43e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1949233477 56 YLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSL--ALAFTTEVHTFWLLRAVQAFTGAAATVVVPGII 125
Cdd:cd17344 71 FLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTAlfGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVV 142
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-162 |
4.10e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 8 FNTRILLPLLASIVAITpLAIDMYLPAML-VIANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSL 86
Cdd:COG2211 225 LKNRPFLLLLLAYLLFF-LALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 87 FGLSSLALAFTTEvHTFWLLRAVQAFTG---AAATVVVPGII--------RHIYQKNTAKGMSYVSMIMMIAPLLAPSIG 155
Cdd:COG2211 304 AALGLLLLFFLGP-GNLWLLLVLAALAGiglGAILVLPWAMLadvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
....*..
gi 1949233477 156 SVILGFS 162
Cdd:COG2211 383 GLLLALF 389
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
54-170 |
4.72e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.79 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 54 SIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLAlafTTEVHTFWLLRAVQAFTGAAATVVVPGII-------- 125
Cdd:PRK11551 57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLA---TAQAWDFPSLLVARLLTGVGLGGALPNLIaltseavg 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1949233477 126 -RHiyqKNTAKGMSYVSmiMMIAPLLAPSIGSVILGFSLWSTIFIV 170
Cdd:PRK11551 134 pRL---RGTAVSLMYCG--VPFGGALASVIGVLAAGDAAWRHIFYV 174
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
32-170 |
8.72e-03 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 38.17 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949233477 32 LPAMlviANDLNTSMPNVQISLSIYLAGYALGMLFFGPIADQIGRRKLARIGLSLFGLSSLALAFTTEVHTFWLLRAVQA 111
Cdd:PRK10504 33 LPSM---AQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQG 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1949233477 112 FTGAaatVVVP----GIIRHIYQKNTAKGMSYVSMIMMIAPLLAPSIGSVILGFSLWSTIFIV 170
Cdd:PRK10504 110 VGGA---MMVPvgrlTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLI 169
|
|
| |
