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Conserved domains on  [gi|1957667807|ref|WP_201055198|]
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DEAD/DEAH box helicase, partial [Streptomyces sp. MBT53]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 13029023)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 10-174 2.27e-61

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 187.54  E-value: 2.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGkgneGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELW----IAGGKIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:cd17990    77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSAT 156


                  ....*
gi 1957667807 170 TDAQG 174
Cdd:cd17990   157 LDGDG 161
 
Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 10-174 2.27e-61

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 187.54  E-value: 2.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGkgneGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELW----IAGGKIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:cd17990    77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSAT 156


                  ....*
gi 1957667807 170 TDAQG 174
Cdd:cd17990   157 LDGDG 161
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-173 1.06e-58

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 195.68  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   1 MIRYDALDALPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLlgkgNEGPARRVVVAEPRRIAARAAARRMA 80
Cdd:COG1643     1 MSLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLEL----GWGAGGRIGMLEPRRLAARAAAERMA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  81 WLLGEKVGESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPE 160
Cdd:COG1643    77 EELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPD 156

                         170
                  ....*....|...
gi 1957667807 161 LRLLAASATTDAQ 173
Cdd:COG1643   157 LKLLVMSATLDAE 169
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 10-173 2.01e-43

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 153.00  E-value: 2.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLAL--AGLLGkgnegpaRRVVVAEPRRIAARAAARRMAWLLGEKV 87
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALldAPGIG-------GKIIMLEPRRLAARSAAQRLASQLGEAV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  88 GESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAAS 167
Cdd:TIGR01970  74 GQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMS 153


                  ....*.
gi 1957667807 168 ATTDAQ 173
Cdd:TIGR01970 154 ATLDGE 159
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 10-173 9.64e-40

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 142.76  E-value: 9.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALagLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:PRK11664    4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQL--LQHGGING---KIIMLEPRRLAARNVAQRLAEQLGEKPGE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:PRK11664   79 TVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLLIMSAT 158


                  ....
gi 1957667807 170 TDAQ 173
Cdd:PRK11664  159 LDND 162
DEXDc smart00487
DEAD-like helicases superfamily;
18-169 7.37e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 71.75  E-value: 7.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   18 GLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTV-- 95
Cdd:smart00487  16 AIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG---RVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGgd 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1957667807   96 ----RGERVVGRHARVEVVTTGVLLQRLQRDQ-ELTGVDTVVLDECHerHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:smart00487  93 skreQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAH--RLLDGGFGDQLEKLLKLLPKNVQLLLLSAT 169
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 21-169 2.81e-07

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 47.62  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  21 AALEAGGAAVLVAPPGTGKTTLVPLALAGLLGKGNEGParRVVVAEPR---RIAARAAARRMAWLLGEKVGESVGYTVRG 97
Cdd:pfam00270   9 PAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGP--QALVLAPTrelAEQIYEELKKLGKGLGLKVASLLGGDSRK 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1957667807  98 ERV-VGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHeRHLDADtvaaFLVDVRE---ALRPELRLLAASAT 169
Cdd:pfam00270  87 EQLeKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMG----FGPDLEEilrRLPKKRQILLLSAT 157
 
Name Accession Description Interval E-value
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 10-174 2.27e-61

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 187.54  E-value: 2.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGkgneGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELW----IAGGKIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:cd17990    77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRDDLRLLAMSAT 156


                  ....*
gi 1957667807 170 TDAQG 174
Cdd:cd17990   157 LDGDG 161
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-173 1.06e-58

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 195.68  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   1 MIRYDALDALPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLlgkgNEGPARRVVVAEPRRIAARAAARRMA 80
Cdd:COG1643     1 MSLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLEL----GWGAGGRIGMLEPRRLAARAAAERMA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  81 WLLGEKVGESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPE 160
Cdd:COG1643    77 EELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRPD 156

                         170
                  ....*....|...
gi 1957667807 161 LRLLAASATTDAQ 173
Cdd:COG1643   157 LKLLVMSATLDAE 169
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 10-173 2.01e-43

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 153.00  E-value: 2.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLAL--AGLLGkgnegpaRRVVVAEPRRIAARAAARRMAWLLGEKV 87
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALldAPGIG-------GKIIMLEPRRLAARSAAQRLASQLGEAV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  88 GESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAAS 167
Cdd:TIGR01970  74 GQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSLREDLKILAMS 153


                  ....*.
gi 1957667807 168 ATTDAQ 173
Cdd:TIGR01970 154 ATLDGE 159
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 10-173 9.64e-40

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 142.76  E-value: 9.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALagLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:PRK11664    4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQL--LQHGGING---KIIMLEPRRLAARNVAQRLAEQLGEKPGE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:PRK11664   79 TVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRDDLKLLIMSAT 158


                  ....
gi 1957667807 170 TDAQ 173
Cdd:PRK11664  159 LDND 162
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 30-172 1.70e-30

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 108.32  E-value: 1.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTLVPLALA-GLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARVE 108
Cdd:cd17917     5 VIVGETGSGKTTQVPQFLLeDGLAKGGKG---RIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1957667807 109 VVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAASATTDA 172
Cdd:cd17917    82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRK-RPDLKVILMSATLDA 144
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 10-173 4.20e-20

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 82.12  E-value: 4.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLlGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL-GRGIRG---LIGHTQPRRLAARSVAERIAEELKTELGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLvdvREAL--RPELRLLAAS 167
Cdd:cd17989    77 AVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYL---KQLLprRPDLKVIITS 153


                  ....*.
gi 1957667807 168 ATTDAQ 173
Cdd:cd17989   154 ATIDAE 159
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 22-173 7.15e-20

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 81.75  E-value: 7.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  22 ALEAGGAAVLVAPPGTGKTTLVP--LALAGLLGKGnegpaRRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGER 99
Cdd:cd17980    13 LVENYQTIVIVGETGCGKSTQIPqyLAEAGWTAGG-----RVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVGYCIRFDD 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1957667807 100 VVGRHA-RVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAASATTDAQ 173
Cdd:cd17980    88 CTDPQAtRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKK-RGDLRLIVASATLDAE 161
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 36-171 1.38e-19

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 82.19  E-value: 1.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  36 GTGKTTLVPLALAGLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGR-HARVEVVTTGV 114
Cdd:cd17972    85 GCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGV 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1957667807 115 LLQRLQRDqeLTGVDTVVLDECHERHLDADTVAAFLVDVREALrPELRLLAASATTD 171
Cdd:cd17972   165 LLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAY-PDLRVILMSATID 218
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 36-173 7.22e-18

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 76.42  E-value: 7.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  36 GTGKTTLVPLALAGLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARVEVVTTGVL 115
Cdd:cd17985    27 GCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQSVGYQIRLESVKSSATRLLYCTTGVL 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1957667807 116 LQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVReALRPELRLLAASATTDAQ 173
Cdd:cd17985   107 LRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLM-VQRPDLKVILMSATLNAE 163
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 30-173 1.52e-17

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 75.60  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTLVP--LALAGLLGKGNEGparrvvVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARV 107
Cdd:cd17971    26 VVIGETGSGKTTQITqyLAEAGYTSRGKIG------CTQPRRVAAMSVAKRVAEEFGCCLGQEVGYTIRFEDCTSPETVI 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1957667807 108 EVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAASATTDAQ 173
Cdd:cd17971   100 KYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQK-RPDLKLIVTSATLDAV 164
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 10-173 1.06e-16

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 73.31  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLAL--AGLLGKGnegpaRRVVVAEPRRIAARAAARRMAWLLGEKV 87
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLheAGYTKGG-----GKIGCTQPRRVAAMSVAARVAEEMGVKL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  88 GESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAAS 167
Cdd:cd17974    76 GNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARF-RPDLKLLISS 154


                  ....*.
gi 1957667807 168 ATTDAQ 173
Cdd:cd17974   155 ATMDAE 160
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 30-173 1.44e-16

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 72.95  E-value: 1.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTLVP---LALAGLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKV--GESVGYTVRGE-RVVGR 103
Cdd:cd17981    21 VISGETGCGKTTQVTqfiLDDAIERGKGSSC---RIVCTQPRRISAISVAERVAAERAESCglGNSTGYQIRLEsRKPRK 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807 104 HARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREaLRPELRLLAASATTDAQ 173
Cdd:cd17981    98 QGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLP-FRSDLKVILMSATLNAE 166
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 10-173 1.46e-16

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 72.90  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGE-RVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREaLRPELRLLAASA 168
Cdd:cd17976    81 NVGYQVRLEsRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQ-LNPELRVVLMSA 159


                  ....*
gi 1957667807 169 TTDAQ 173
Cdd:cd17976   160 TGDNQ 164
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 30-173 1.97e-16

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 72.64  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTLVP-LALAGLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGES-----VGYTVRGERVVGR 103
Cdd:cd17975    21 VVAGETGSGKSTQVPqFLLEDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESGPGgknslCGYQIRMESRTGE 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1957667807 104 HARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVaafLVDVREAL--RPELRLLAASATTDAQ 173
Cdd:cd17975   101 ATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFL---LIILKEILhkRSDLHLILMSATVDCE 169
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 30-173 5.67e-16

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 74.71  E-value: 5.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   30 VLVA-PPGTGKTTLVP-LALAglLGKGNEG------PAR---RVVVAEprriaaraaarrMAWLLGEKVGESVGYTVRGE 98
Cdd:PRK11131    92 VIVAgETGSGKTTQLPkICLE--LGRGVKGlightqPRRlaaRTVANR------------IAEELETELGGCVGYKVRFN 157

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1957667807   99 RVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLvdvREAL--RPELRLLAASATTDAQ 173
Cdd:PRK11131   158 DQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYL---KELLprRPDLKVIITSATIDPE 231
DEXDc smart00487
DEAD-like helicases superfamily;
18-169 7.37e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 71.75  E-value: 7.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   18 GLDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLGKGNEGparRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTV-- 95
Cdd:smart00487  16 AIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGG---RVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGgd 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1957667807   96 ----RGERVVGRHARVEVVTTGVLLQRLQRDQ-ELTGVDTVVLDECHerHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:smart00487  93 skreQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAH--RLLDGGFGDQLEKLLKLLPKNVQLLLLSAT 169
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 10-172 2.62e-15

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 69.69  E-value: 2.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVP--LALAGLLGKGNEGparrvvVAEPRRIAARAAARRMAWLLGEKV 87
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPqyLYEAGFARGGMIG------ITQPRRVAAVSVAKRVAEEMGVEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  88 GESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDV----REALRPELRL 163
Cdd:cd17978    75 GQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAqrrrKEQKLSPLKV 154


                  ....*....
gi 1957667807 164 LAASATTDA 172
Cdd:cd17978   155 IIMSATLDA 163
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 30-173 3.87e-15

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 69.37  E-value: 3.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTLVPLALagLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARVEV 109
Cdd:cd17973    33 VLVGETGSGKTTQIPQFV--LDDELPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKY 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1957667807 110 VTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAASATTDAQ 173
Cdd:cd17973   111 MTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRR-RPDLKLIVMSATLDAG 173
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 10-172 8.48e-14

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 65.62  E-value: 8.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALagLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFL--LDDCYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQ-RDQELTGVDTVVLDECHERHLDADTVaafLVDVREALR--PELRLLAA 166
Cdd:cd17987    79 TVGYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFSDFL---LTKLRDILQkhPNLKLILS 155


                  ....*.
gi 1957667807 167 SATTDA 172
Cdd:cd17987   156 SAALDV 161
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 30-173 3.21e-13

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 64.02  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  30 VLVAPPGTGKTTlvplALAGLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARVEV 109
Cdd:cd17983    21 IVVGETGSGKTT----QLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKY 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1957667807 110 VTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVReALRPELRLLAASATTDAQ 173
Cdd:cd17983    97 MTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVV-ARRRDLKLIVTSATMDAD 159
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 36-169 7.17e-13

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 63.23  E-value: 7.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  36 GTGKTTLVP--LALAGLlgkgnegpaRRVVVAEPRRIAARAAARRMAWLLGEKVGESVGYTVRGERVVGRHARVEVVTTG 113
Cdd:cd17979    27 GCGKSTQVPqyLLAAGF---------RHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIRFERTRTLATKLLFLTEG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1957667807 114 VLLQRLQRDQELTGVDTVVLDECHERHLDADtvaaFLVDVREAL---RPELRLLAASAT 169
Cdd:cd17979    98 LLLRQIQRDASLPQYNVLILDEVHERHLHGD----FLLGVLRCLlrlRPDLKLILMSAT 152
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 36-169 2.49e-11

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 59.29  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  36 GTGKTTLVPLAL--AGLlgkGNEGPAR--RVVVAEPRRIAARAAARRMAWLLGeKVGESVGYTVRGERVVGRHARVEVVT 111
Cdd:cd17982    27 GSGKTTQVPQFLyeAGF---GSPESDNpgMIGITQPRRVAAVSMAKRVAEELN-VFGKEVSYQIRYDSTVSENTKIKFMT 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1957667807 112 TGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFL---VDVREALRPE------LRLLAASAT 169
Cdd:cd17982   103 DGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsriVPLRAKLYLQdqtvkpLKLVIMSAT 169
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 10-172 9.06e-11

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 57.51  E-value: 9.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLALagLLGKGNEGPARRVVVAEPRRIAARAAARRMAWLLGEKVGE 89
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFI--LDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  90 SVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHER--HLDadtvaAFLVDVREALRPELR---LL 164
Cdd:cd17988    79 LVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERdqELD-----FLLLVVRRLLRTNSRhvkII 153


                  ....*...
gi 1957667807 165 AASATTDA 172
Cdd:cd17988   154 LMSATISC 161
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 10-173 1.68e-10

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 56.79  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVAPPGTGKTTLVPLAL--AGLLGKGnegparRVVVAEPRRIAARAAARRMAWLLGEKV 87
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLyeAGFSQHG------MIGVTQPRRVAAISVAQRVAEEMKCTL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  88 GESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREALRP----ELRL 163
Cdd:cd17984    75 GSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkeHLKV 154

                         170
                  ....*....|
gi 1957667807 164 LAASATTDAQ 173
Cdd:cd17984   155 VVMSATLELA 164
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 10-164 5.80e-09

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 52.59  E-value: 5.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  10 LPVRSALPGLDAALEAGGAAVLVA-PPGTGKTTLVP-----LALAGLLGKGnegparRVVVAEPRRIAARAAARRMAWLL 83
Cdd:cd17986     1 LPIWAAKFTFLEQLESPSGIVLVSgEPGSGKSTQVPqwcaeFALSRGFQKG------QVTVTQPHPLAARSLALRVADEM 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  84 GEKVGESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRL 163
Cdd:cd17986    75 DLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQ-RPELRV 153


                  .
gi 1957667807 164 L 164
Cdd:cd17986   154 V 154
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 26-169 2.64e-07

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 47.40  E-value: 2.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  26 GGAAVLVAPPGTGKTTLVPLALAGLLgkgnEGPARRVVVAEPRRIAARAAARRMAWLLGEKVgeSVGYTVRG------ER 99
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLL----LKKGKKVLVLVPTKALALQTAERLRELFGPGI--RVAVLVGGssaeerEK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1957667807 100 VVGRHARVEVVTTGVLLQRLQRDQ--ELTGVDTVVLDECHerHLDADTVAAFLVD--VREALRPELRLLAASAT 169
Cdd:cd00046    75 NKLGDADIIIATPDMLLNLLLREDrlFLKDLKLIIVDEAH--ALLIDSRGALILDlaVRKAGLKNAQVILLSAT 146
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 21-169 2.81e-07

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 47.62  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  21 AALEAGGAAVLVAPPGTGKTTLVPLALAGLLGKGNEGParRVVVAEPR---RIAARAAARRMAWLLGEKVGESVGYTVRG 97
Cdd:pfam00270   9 PAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGP--QALVLAPTrelAEQIYEELKKLGKGLGLKVASLLGGDSRK 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1957667807  98 ERV-VGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHeRHLDADtvaaFLVDVRE---ALRPELRLLAASAT 169
Cdd:pfam00270  87 EQLeKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMG----FGPDLEEilrRLPKKRQILLLSAT 157
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
5-169 2.66e-05

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 43.47  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   5 DALDALpvrsalpgLDAALEAGGAAVLVAPPGTGKtTLVPLALAGLLGKGnegpaRRVVVAEPRRIaaraaarrmawLLG 84
Cdd:COG1061    87 EALEAL--------LAALERGGGRGLVVAPTGTGK-TVLALALAAELLRG-----KRVLVLVPRRE-----------LLE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  85 ---EKVGESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHerHLDADTvaafLVDVREALRPeL 161
Cdd:COG1061   142 qwaEELRRFLGDPLAGGGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAH--HAGAPS----YRRILEAFPA-A 214


                  ....*...
gi 1957667807 162 RLLAASAT 169
Cdd:COG1061   215 YRLGLTAT 222
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 87-168 3.44e-05

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 42.12  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  87 VGESVGYTVRGERVVGRHARVEVVTTGVLLQRLQRDQELTGVDTVVLDECHERHLDADTVAAFLVDVREAlRPELRLLAA 166
Cdd:cd17977    77 IGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLS-RPELKLVII 155


                  ..
gi 1957667807 167 SA 168
Cdd:cd17977   156 TC 157
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
21-137 3.70e-04

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 39.92  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  21 AALEAGGAAVLVAPPGTGKT----TLVPLALAGllgkgnegpARRVVVAEPrriaaraaarrmawL----------LGEK 86
Cdd:COG4581    35 LALEAGRSVLVAAPTGSGKTlvaeFAIFLALAR---------GRRSFYTAP--------------IkalsnqkffdLVER 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1957667807  87 VG-ESVGyTVRGERVVGRHARVEVVTTGVLLQRLQRD-QELTGVDTVVLDECH 137
Cdd:COG4581    92 FGaENVG-LLTGDASVNPDAPIVVMTTEILRNMLYREgADLEDVGVVVMDEFH 143
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 22-169 5.63e-04

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 38.44  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  22 ALEAGGAAVLVAPPGTGKtTLVPLALAGLLGKgnegpaRRVVVAEPRRIAARAaarrmaWL--LGEKVGESVGYTVRGER 99
Cdd:cd17926    14 AHKNNRRGILVLPTGSGK-TLTALALIAYLKE------LRTLIVVPTDALLDQ------WKerFEDFLGDSSIGLIGGGK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1957667807 100 VVGRHARVEVVTT----GVLLQRLQRDQELTGVdtVVLDECHerHLDADTVAAFLVDVREALRPELrllaaSAT 169
Cdd:cd17926    81 KKDFDDANVVVATyqslSNLAEEEKDLFDQFGL--LIVDEAH--HLPAKTFSEILKELNAKYRLGL-----TAT 145
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 26-116 2.54e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 2.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807   26 GGAAVLVAPPGTGKTTLVpLALAGLLGKgnegPARRVVVAEPrriaARAAARRMAWLLGEKVGESVGYTVRGERVVGRHA 105
Cdd:smart00382   2 GEVILIVGPPGSGKTTLA-RALARELGP----PGGGVIYIDG----EDILEEVLDQLLLIIVGGKKASGSGELRLRLALA 72

                           90
                   ....*....|.
gi 1957667807  106 RVEVVTTGVLL 116
Cdd:smart00382  73 LARKLKPDVLI 83
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 29-169 2.77e-03

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 36.37  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  29 AVLVAPPGTGKTTLVPLALAGLLGKGNegpaRRVVVAEPRRIAARAAARRMAwllgekvGESVGYTVrGERVVGRHAR-- 106
Cdd:cd17931     4 TVLDLHPGAGKTTRVLPQIIREAIKKR----LRTLVLAPTRVVAAEMYEALR-------GLPIRYRT-GAVKEEHGGNei 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1957667807 107 VEVVTTGVLLQRLQRDQELTGVDTVVLDECHerHLDADTVAAFLVDVREALRPELRLLAASAT 169
Cdd:cd17931    72 VDYMCHGTFTCRLLSPKRVPNYNLIIMDEAH--FTDPASIAARGYIHTRVEMGEAAVIFMTAT 132
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 19-171 4.00e-03

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 36.09  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  19 LDAALEAGGAAVLVAPPGTGKTTLVPLALAGLLgkgNEGPARRVVVA--EPRRIAARAAARRMAWLLGEKVGESVG-YTV 95
Cdd:cd17921    10 LRALYLSGDSVLVSAPTSSGKTLIAELAILRAL---ATSGGKAVYIAptRALVNQKEADLRERFGPLGKNVGLLTGdPSV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1957667807  96 RGERVvgRHARVEVVTTGVLLQRLQRDQELTG--VDTVVLDECH-----ERHLDADTVAAFLVDvreaLRPELRLLAASA 168
Cdd:cd17921    87 NKLLL--AEADILVATPEKLDLLLRNGGERLIqdVRLVVVDEAHligdgERGVVLELLLSRLLR----INKNARFVGLSA 160


                  ...
gi 1957667807 169 TTD 171
Cdd:cd17921   161 TLP 163
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
17-43 7.26e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 35.66  E-value: 7.26e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1957667807  17 PGLDAALEAG---GAAVLVA-PPGTGKTTLV 43
Cdd:COG0467     7 PGLDELLGGGlprGSSTLLSgPPGTGKTTLA 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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