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Conserved domains on  [gi|1993222116|ref|WP_204873721|]
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BMC domain-containing protein [Pseudoflavonifractor phocaeensis]

Protein Classification

similar to ethanolamine utilization protein EutS( domain architecture ID 10790903)

protein similar to ethanolamine utilization protein EutS

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EutS COG4810
Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport ...
 12-126 2.19e-60

Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport and metabolism];


:

Pssm-ID: 443838  Cd Length: 117  Bit Score: 181.21  E-value: 2.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  12 GKLRIIQESVPGKEITLAHIIASPDEIIYQKLGLDpnvDYHQAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSGT 91
Cdd:COG4810     6 EKQRIIQEYVPGKQVTLAHIIANPDPDLYEKLGLD---DEEAGAIGILTITPSEAAIIAADIATKAADVEIGFLDRFSGS 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1993222116  92 LIFTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:COG4810    83 LVITGDVSSVESALREVVEYLGNVLGFTVCEITRT 117
 
Name Accession Description Interval E-value
EutS COG4810
Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport ...
 12-126 2.19e-60

Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport and metabolism];


Pssm-ID: 443838  Cd Length: 117  Bit Score: 181.21  E-value: 2.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  12 GKLRIIQESVPGKEITLAHIIASPDEIIYQKLGLDpnvDYHQAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSGT 91
Cdd:COG4810     6 EKQRIIQEYVPGKQVTLAHIIANPDPDLYEKLGLD---DEEAGAIGILTITPSEAAIIAADIATKAADVEIGFLDRFSGS 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1993222116  92 LIFTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:COG4810    83 LVITGDVSSVESALREVVEYLGNVLGFTVCEITRT 117
BMC_PduU-EutS cd07046
1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), ...
 14-126 1.36e-55

1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; PduU encapsulates several related enzymes within a shell composed of a few thousand protein subunits. PduU exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu organelle. This proteinaceous noncarboxysome microcompartment is involved in coenzyme B12-dependent degradation of 1,2-propanediol. The core of PduU is related to the typical BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins. EutS proteins included in this CD are sequence homologs of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine. Although it has been suggested that EutS might also form hexamers and play similar functional roles in the construction of the eut organelle outer shell at present no experimental evidence directly supports this view.


Pssm-ID: 132886  Cd Length: 110  Bit Score: 168.59  E-value: 1.36e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  14 LRIIQESVPGKEITLAHIIASPDEIIYQKLGLDPNVDyhqAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSGTLI 93
Cdd:cd07046     1 QRIIQEYVPGKQITLAHLIANPDPEIYQKLGLNPGVD---EAIGILTITPSEAAIIAADIATKAADVEIGFLDRFSGALV 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1993222116  94 FTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:cd07046    78 ITGDVSEVESALEAVVDYLRETLGFTVCPITKT 110
PRK15468 PRK15468
ethanolamine utilization microcompartment protein EutS;
11-126 1.44e-28

ethanolamine utilization microcompartment protein EutS;


Pssm-ID: 185365  Cd Length: 111  Bit Score: 100.45  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  11 LGKLRIIQESVPGKEITLAHIIASPDEIIYQKLGLDpnvdyHQAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG 90
Cdd:PRK15468    1 MDKERIIQEFVPGKQVTLAHLIAHPGEELAKKIGVP-----DAGAIGIMTLTPGETAMIAGDLALKAADVHIGFLDRFSG 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1993222116  91 TLIFTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:PRK15468   76 ALVIYGSVGAVEEALSQTVSGLGRLLNYTLCEMTKS 111
BMC smart00877
Bacterial microcompartments are primitive organelles composed entirely of protein subunits; ...
 55-125 1.38e-09

Bacterial microcompartments are primitive organelles composed entirely of protein subunits; The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure.


Pssm-ID: 197945  Cd Length: 75  Bit Score: 50.65  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993222116   55 AIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG---TLIFTGRIGNVEASVKAVLAYLESKLGFTVCEITR 125
Cdd:smart00877   1 ALGIIETRGAAAAIEAADAALKAANVELVGYESIGGgkvTVIITGDVAAVRAAVEAGLEAAERLGLVSSHVIPR 74
BMC pfam00936
BMC domain; Bacterial microcompartments are primitive organelles composed entirely of protein ...
 55-115 8.01e-07

BMC domain; Bacterial microcompartments are primitive organelles composed entirely of protein subunits. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure.


Pssm-ID: 425954 [Multi-domain]  Cd Length: 74  Bit Score: 43.59  E-value: 8.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993222116  55 AIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG---TLIFTGRIGNVEASVKAVLAYLESK 115
Cdd:pfam00936   1 ALGLIETRGLAAGIEAADAMLKAANVELVGYELIGGgkvTVIITGDVAAVKAAVEAGVEAAERI 64
 
Name Accession Description Interval E-value
EutS COG4810
Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport ...
 12-126 2.19e-60

Ethanolamine utilization protein EutS, microcompartment shell protein [Amino acid transport and metabolism];


Pssm-ID: 443838  Cd Length: 117  Bit Score: 181.21  E-value: 2.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  12 GKLRIIQESVPGKEITLAHIIASPDEIIYQKLGLDpnvDYHQAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSGT 91
Cdd:COG4810     6 EKQRIIQEYVPGKQVTLAHIIANPDPDLYEKLGLD---DEEAGAIGILTITPSEAAIIAADIATKAADVEIGFLDRFSGS 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1993222116  92 LIFTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:COG4810    83 LVITGDVSSVESALREVVEYLGNVLGFTVCEITRT 117
BMC_PduU-EutS cd07046
1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), ...
 14-126 1.36e-55

1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; PduU encapsulates several related enzymes within a shell composed of a few thousand protein subunits. PduU exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu organelle. This proteinaceous noncarboxysome microcompartment is involved in coenzyme B12-dependent degradation of 1,2-propanediol. The core of PduU is related to the typical BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins. EutS proteins included in this CD are sequence homologs of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine. Although it has been suggested that EutS might also form hexamers and play similar functional roles in the construction of the eut organelle outer shell at present no experimental evidence directly supports this view.


Pssm-ID: 132886  Cd Length: 110  Bit Score: 168.59  E-value: 1.36e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  14 LRIIQESVPGKEITLAHIIASPDEIIYQKLGLDPNVDyhqAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSGTLI 93
Cdd:cd07046     1 QRIIQEYVPGKQITLAHLIANPDPEIYQKLGLNPGVD---EAIGILTITPSEAAIIAADIATKAADVEIGFLDRFSGALV 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1993222116  94 FTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:cd07046    78 ITGDVSEVESALEAVVDYLRETLGFTVCPITKT 110
PRK15468 PRK15468
ethanolamine utilization microcompartment protein EutS;
11-126 1.44e-28

ethanolamine utilization microcompartment protein EutS;


Pssm-ID: 185365  Cd Length: 111  Bit Score: 100.45  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993222116  11 LGKLRIIQESVPGKEITLAHIIASPDEIIYQKLGLDpnvdyHQAAIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG 90
Cdd:PRK15468    1 MDKERIIQEFVPGKQVTLAHLIAHPGEELAKKIGVP-----DAGAIGIMTLTPGETAMIAGDLALKAADVHIGFLDRFSG 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1993222116  91 TLIFTGRIGNVEASVKAVLAYLESKLGFTVCEITRT 126
Cdd:PRK15468   76 ALVIYGSVGAVEEALSQTVSGLGRLLNYTLCEMTKS 111
BMC smart00877
Bacterial microcompartments are primitive organelles composed entirely of protein subunits; ...
 55-125 1.38e-09

Bacterial microcompartments are primitive organelles composed entirely of protein subunits; The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure.


Pssm-ID: 197945  Cd Length: 75  Bit Score: 50.65  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993222116   55 AIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG---TLIFTGRIGNVEASVKAVLAYLESKLGFTVCEITR 125
Cdd:smart00877   1 ALGIIETRGAAAAIEAADAALKAANVELVGYESIGGgkvTVIITGDVAAVRAAVEAGLEAAERLGLVSSHVIPR 74
BMC pfam00936
BMC domain; Bacterial microcompartments are primitive organelles composed entirely of protein ...
 55-115 8.01e-07

BMC domain; Bacterial microcompartments are primitive organelles composed entirely of protein subunits. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure.


Pssm-ID: 425954 [Multi-domain]  Cd Length: 74  Bit Score: 43.59  E-value: 8.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993222116  55 AIAVMAICPCETTVIAGDIALKTSKIEMGFLDRFSG---TLIFTGRIGNVEASVKAVLAYLESK 115
Cdd:pfam00936   1 ALGLIETRGLAAGIEAADAMLKAANVELVGYELIGGgkvTVIITGDVAAVKAAVEAGVEAAERI 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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