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Conserved domains on  [gi|1994267186|ref|WP_205229364|]
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O-methyltransferase [Desulfobulbus rhabdoformis]

Protein Classification

O-methyltransferase( domain architecture ID 11467877)

O-methyltransferase of the class I-like SAM-binding methyltransferase superfamily, such as catechol O-methyltransferases that can use various catechol-like compounds

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.-.-
Gene Ontology:  GO:0008757|GO:0032259|GO:1904047|GO:0008168|GO:0008171
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 33-107 4.60e-29

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443298  Cd Length: 173  Bit Score: 103.73  E-value: 4.60e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1994267186  33 RDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQGD 107
Cdd:COG4122     2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGD 76
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 33-107 4.60e-29

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 103.73  E-value: 4.60e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1994267186  33 RDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQGD 107
Cdd:COG4122     2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGD 76
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 2-108 2.00e-14

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 66.75  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994267186   2 DLDYFLKELEQKGIHNdeiqadrALKYLNITRDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYS 81
Cdd:pfam01596   5 YEHEYLKELREETAKL-------PLAPMQVSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDID 77

                          90       100
                  ....*....|....*....|....*..
gi 1994267186  82 DRKTKEALSNFERVGLANKIALLQGDS 108
Cdd:pfam01596  78 PEAYEIAKKFIQKAGVAHKISFILGPA 104
PLN02589 PLN02589
caffeoyl-CoA O-methyltransferase
 19-106 3.60e-08

caffeoyl-CoA O-methyltransferase


Pssm-ID: 166230  Cd Length: 247  Bit Score: 50.38  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994267186  19 EIQADRALKYLNITRDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLA 98
Cdd:PLN02589   51 ELTAKHPWNIMTTSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALALPEDGKILAMDINRENYELGLPVIQKAGVA 130


                  ....*...
gi 1994267186  99 NKIALLQG 106
Cdd:PLN02589  131 HKIDFREG 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-108 7.98e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 7.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1994267186  50 KILEIGTSNGYSTLWLASSipPAGTVTTIEYSDRKTKEALSNfERVGLANKIALLQGDS 108
Cdd:cd02440     1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKA-AAALLADNVEVLKGDA 56
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 50-121 4.16e-03

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 35.80  E-value: 4.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994267186  50 KILEIGTSNGYSTLWLASSIpPAGTVTTIEYSDRKTKEALSNFERVGLANKIAL---LQGDSKR-EYRRlsVITAC 121
Cdd:TIGR04188 110 RVLEIGTGTGYSAALLCHRL-GDDNVTSVEVDPGLAARAASALAAAGYAPTVVTgdgLLGHPPRaPYDR--IIATC 182
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 33-107 4.60e-29

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 103.73  E-value: 4.60e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1994267186  33 RDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQGD 107
Cdd:COG4122     2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGD 76
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 2-108 2.00e-14

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 66.75  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994267186   2 DLDYFLKELEQKGIHNdeiqadrALKYLNITRDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYS 81
Cdd:pfam01596   5 YEHEYLKELREETAKL-------PLAPMQVSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDID 77

                          90       100
                  ....*....|....*....|....*..
gi 1994267186  82 DRKTKEALSNFERVGLANKIALLQGDS 108
Cdd:pfam01596  78 PEAYEIAKKFIQKAGVAHKISFILGPA 104
PLN02589 PLN02589
caffeoyl-CoA O-methyltransferase
 19-106 3.60e-08

caffeoyl-CoA O-methyltransferase


Pssm-ID: 166230  Cd Length: 247  Bit Score: 50.38  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994267186  19 EIQADRALKYLNITRDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLA 98
Cdd:PLN02589   51 ELTAKHPWNIMTTSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALALPEDGKILAMDINRENYELGLPVIQKAGVA 130


                  ....*...
gi 1994267186  99 NKIALLQG 106
Cdd:PLN02589  131 HKIDFREG 138
PLN02781 PLN02781
Probable caffeoyl-CoA O-methyltransferase
 19-110 5.10e-08

Probable caffeoyl-CoA O-methyltransferase


Pssm-ID: 215417  Cd Length: 234  Bit Score: 49.81  E-value: 5.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994267186  19 EIQADRALKYLNITR-----DTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFE 93
Cdd:PLN02781   35 ELREATVQKYGNLSEmevpvDEGLFLSMLVKIMNAKNTLEIGVFTGYSLLTTALALPEDGRITAIDIDKEAYEVGLEFIK 114

                          90
                  ....*....|....*..
gi 1994267186  94 RVGLANKIALLQGDSKR 110
Cdd:PLN02781  115 KAGVDHKINFIQSDALS 131
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-115 1.38e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 46.53  E-value: 1.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994267186  52 LEIGTSNGYSTLWLASSIPPAGT--VTTIEYsDRKTKEALSNFERVGLANKIALLQGDSKREYRRL 115
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDNGLgrLTAVDP-DPGAEEAGALLRKAGLDDRVRLIVGDSREALPSL 65
PLN02476 PLN02476
O-methyltransferase
 29-106 1.80e-06

O-methyltransferase


Pssm-ID: 178094  Cd Length: 278  Bit Score: 45.44  E-value: 1.80e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1994267186  29 LNITRDTGEFLRVLVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQG 106
Cdd:PLN02476  100 MQVSPDQAQLLAMLVQILGAERCIEVGVYTGYSSLAVALVLPESGCLVACERDSNSLEVAKRYYELAGVSHKVNVKHG 177
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 50-107 5.92e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 43.54  E-value: 5.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1994267186  50 KILEIGTSNGYSTLwLASSIppAGTVTTIEYSDRKTKEALSNFERVGLANkIALLQGD 107
Cdd:COG2518    69 RVLEIGTGSGYQAA-VLARL--AGRVYSVERDPELAERARERLAALGYDN-VTVRVGD 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 49-107 1.82e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 42.45  E-value: 1.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1994267186  49 SKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQGD 107
Cdd:COG2519    93 ARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGD 151
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 42-110 3.58e-05

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 41.72  E-value: 3.58e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1994267186  42 LVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKIALLQGDSKR 110
Cdd:PRK13944   67 LIEPRPGMKILEVGTGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIERLGYWGVVEVYHGDGKR 135
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
42-107 8.46e-05

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 40.43  E-value: 8.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994267186  42 LVRATRASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANkIALLQGD 107
Cdd:pfam01135  68 LLELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN-VIVVVGD 132
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
42-107 3.92e-04

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.65  E-value: 3.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994267186  42 LVRATRASKILEIGTSNGYSTLWLASSippAGTVTTIEYSDRKTKEALSNFERVGLANkIALLQGD 107
Cdd:PRK00312   73 LLELKPGDRVLEIGTGSGYQAAVLAHL---VRRVFSVERIKTLQWEAKRRLKQLGLHN-VSVRHGD 134
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-108 7.98e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 7.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1994267186  50 KILEIGTSNGYSTLWLASSipPAGTVTTIEYSDRKTKEALSNfERVGLANKIALLQGDS 108
Cdd:cd02440     1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKA-AAALLADNVEVLKGDA 56
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 47-101 1.01e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 37.90  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1994267186  47 RASKILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANKI 101
Cdd:PRK13943   80 KGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRRLGIENVI 134
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 50-107 1.65e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.24  E-value: 1.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1994267186  50 KILEIGTSNGYSTLWLASSIPPAGTVTTIEYSDRKTKEALSNFERVGLANkIALLQGD 107
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGD 62
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 50-121 4.16e-03

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 35.80  E-value: 4.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994267186  50 KILEIGTSNGYSTLWLASSIpPAGTVTTIEYSDRKTKEALSNFERVGLANKIAL---LQGDSKR-EYRRlsVITAC 121
Cdd:TIGR04188 110 RVLEIGTGTGYSAALLCHRL-GDDNVTSVEVDPGLAARAASALAAAGYAPTVVTgdgLLGHPPRaPYDR--IIATC 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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