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Conserved domains on  [gi|2023668590|ref|WP_209515949|]
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DHA2 family efflux MFS transporter permease subunit [Streptomyces syringium]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 41-426 4.82e-58

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 199.14  E-value: 4.82e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:TIGR00711  10 GTFMAVLDSTIVNVAIPTIAGDL-GSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVASYRILPPRTGPAGRMPDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALA-LLRSRRHPAPAVE 279
Cdd:TIGR00711 169 VVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAfVVWELTDDNPLVD 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 280 ISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYA-RAHQRVAVVVGG 358
Cdd:TIGR00711 249 LRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGdKIDPRKLVTIGL 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023668590 359 ILFAVQCGIWMIGLESKPDFLVIWLPaTLIGGVGIGAVMTGLSSASATALPPRLFAAGAGLATTARQV 426
Cdd:TIGR00711 329 ILYAVGFYWRAFTFTPDTPFLAIALP-QFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 41-426 4.82e-58

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 199.14  E-value: 4.82e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:TIGR00711  10 GTFMAVLDSTIVNVAIPTIAGDL-GSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVASYRILPPRTGPAGRMPDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALA-LLRSRRHPAPAVE 279
Cdd:TIGR00711 169 VVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAfVVWELTDDNPLVD 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 280 ISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYA-RAHQRVAVVVGG 358
Cdd:TIGR00711 249 LRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGdKIDPRKLVTIGL 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023668590 359 ILFAVQCGIWMIGLESKPDFLVIWLPaTLIGGVGIGAVMTGLSSASATALPPRLFAAGAGLATTARQV 426
Cdd:TIGR00711 329 ILYAVGFYWRAFTFTPDTPFLAIALP-QFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 39-410 1.71e-51

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 178.52  E-value: 1.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  39 CGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAI 118
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDL-GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 119 APTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLG 198
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 199 VMLVVAsyrilpprtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapav 278
Cdd:cd17321   161 LVALLL-------------------------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 279 eislwrSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGG 358
Cdd:cd17321   167 ------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2023668590 359 ILFAVqCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPP 410
Cdd:cd17321   241 LLLTA-VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK 291
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-411 2.29e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 137.41  E-value: 2.29e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  33 LTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLA 112
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 113 SGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFL 192
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 193 INVPLGVMLVVASYRILPPRtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalalLRSRR 272
Cdd:COG2814   169 VNAVLALLALLLLLRLLPES-------------------------------------------------------RPAAR 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 273 HPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRV 352
Cdd:COG2814   194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 353 AVVVGGILFAVqCGIWMIGLeskPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:COG2814   274 RLLLIGLLLLA-LGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
MFS_1 pfam07690
Major Facilitator Superfamily;
41-412 3.01e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 3.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVASYRILPPRTGPAGRmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalalLRSRRHPAPAVEI 280
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPK-------------------------------------------------PAEEARLSLIVAW 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 281 SLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIwGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGIL 360
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2023668590 361 FAVqCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPRL 412
Cdd:pfam07690 274 LLI-LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
PRK10504 PRK10504
putative transporter; Provisional
 43-330 8.87e-23

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 100.96  E-value: 8.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  43 FVAFLDVSVTYVAFPSLHKSFPDASLSALSwVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTV 122
Cdd:PRK10504   20 FMQSLDTTIVNTALPSMAQSLGESPLHMHM-VIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 123 EFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLV 202
Cdd:PRK10504   99 NELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 203 VASYRILPPRTGPAGRMpDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALALLRSRRHPAPAVEISL 282
Cdd:PRK10504  179 IATLMLMPNYTMQTRRF-DLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKL 257

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 283 WRSRKFRVANIAFVL--FGGSMYCWLlaAPLFATEIWGYSEVQAGLALAP 330
Cdd:PRK10504  258 FRTRTFSLGLAGSFAgrIGSGMLPFM--TPVFLQIGLGFSPFHAGLMMIP 305
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 41-426 4.82e-58

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 199.14  E-value: 4.82e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:TIGR00711  10 GTFMAVLDSTIVNVAIPTIAGDL-GSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVASYRILPPRTGPAGRMPDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALA-LLRSRRHPAPAVE 279
Cdd:TIGR00711 169 VVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAfVVWELTDDNPLVD 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 280 ISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYA-RAHQRVAVVVGG 358
Cdd:TIGR00711 249 LRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGdKIDPRKLVTIGL 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023668590 359 ILFAVQCGIWMIGLESKPDFLVIWLPaTLIGGVGIGAVMTGLSSASATALPPRLFAAGAGLATTARQV 426
Cdd:TIGR00711 329 ILYAVGFYWRAFTFTPDTPFLAIALP-QFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 39-410 1.71e-51

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 178.52  E-value: 1.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  39 CGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAI 118
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDL-GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 119 APTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLG 198
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 199 VMLVVAsyrilpprtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapav 278
Cdd:cd17321   161 LVALLL-------------------------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 279 eislwrSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGG 358
Cdd:cd17321   167 ------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2023668590 359 ILFAVqCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPP 410
Cdd:cd17321   241 LLLTA-VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK 291
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 41-410 2.16e-46

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 165.44  E-value: 2.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:cd17503     4 GAFMAILDTTIVNVALPTIMGDL-GASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:cd17503    83 NLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVAsyrilpprtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpAPAVEI 280
Cdd:cd17503   163 ALLL----------------------------------------------------------------------APLLDL 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 281 SLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGR-YARAHQRVAVVVGGI 359
Cdd:cd17503   173 RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRlLDKFGPRLLLLAGLL 252

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2023668590 360 LFAVqcGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPP 410
Cdd:cd17503   253 LLAL--GTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPP 301
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-411 2.29e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 137.41  E-value: 2.29e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  33 LTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLA 112
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 113 SGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFL 192
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 193 INVPLGVMLVVASYRILPPRtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalalLRSRR 272
Cdd:COG2814   169 VNAVLALLALLLLLRLLPES-------------------------------------------------------RPAAR 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 273 HPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRV 352
Cdd:COG2814   194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 353 AVVVGGILFAVqCGIWMIGLeskPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:COG2814   274 RLLLIGLLLLA-LGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-314 3.31e-33

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 127.62  E-value: 3.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  22 TGQDAAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRAL 101
Cdd:COG0477     3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 102 FLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLL 181
Cdd:COG0477    82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 182 VDSFGWPSVFLINVPLGVMLVVASYRILPPRTGPAGRMPDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAV 261
Cdd:COG0477   162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2023668590 262 LLALALLRSRRHPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFAT 314
Cdd:COG0477   242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 41-413 5.51e-33

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 127.68  E-value: 5.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpdASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:cd17502     4 ALFLAALDQTIVATALPTIVAEF--GGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVm 200
Cdd:cd17502    82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 lvvasyrilpprtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapaveI 280
Cdd:cd17502   161 -------------------------------------------------------------------------------L 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 281 SLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRY-ARAHQRVAVVVGGI 359
Cdd:cd17502   162 ALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTGRYKPLIVIGT 241

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2023668590 360 LFAVqCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPRLF 413
Cdd:cd17502   242 ILMS-VGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADV 294
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-411 7.83e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 111.51  E-value: 7.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  39 CGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAI 118
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 119 APTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLG 198
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 199 VMLVVASYRILPPRTGPAGRMPDLIGTLAVALgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapav 278
Cdd:cd17325   161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGL------------------------------------------------ 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 279 eISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGG 358
Cdd:cd17325   193 -RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2023668590 359 ILFAVQCGIWMigleSKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:cd17325   272 LLLSAVALLLL----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
MFS_1 pfam07690
Major Facilitator Superfamily;
41-412 3.01e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 3.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 201 LVVASYRILPPRTGPAGRmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalalLRSRRHPAPAVEI 280
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPK-------------------------------------------------PAEEARLSLIVAW 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 281 SLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIwGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGIL 360
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2023668590 361 FAVqCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPRL 412
Cdd:pfam07690 274 LLI-LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
PRK10504 PRK10504
putative transporter; Provisional
 43-330 8.87e-23

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 100.96  E-value: 8.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  43 FVAFLDVSVTYVAFPSLHKSFPDASLSALSwVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTV 122
Cdd:PRK10504   20 FMQSLDTTIVNTALPSMAQSLGESPLHMHM-VIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 123 EFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLV 202
Cdd:PRK10504   99 NELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 203 VASYRILPPRTGPAGRMpDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALALLRSRRHPAPAVEISL 282
Cdd:PRK10504  179 IATLMLMPNYTMQTRRF-DLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKL 257

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 283 WRSRKFRVANIAFVL--FGGSMYCWLlaAPLFATEIWGYSEVQAGLALAP 330
Cdd:PRK10504  258 FRTRTFSLGLAGSFAgrIGSGMLPFM--TPVFLQIGLGFSPFHAGLMMIP 305
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-411 5.16e-22

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 97.26  E-value: 5.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASG 114
Cdd:cd17474     1 LYAVFFATLLAVLGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 115 LCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDsFGWPSVFLIN 194
Cdd:cd17474    80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 195 VPLGVMLVVASYRILPP--RTGPAGRMPDLIGTLAVALGVGGVVAALTegsswgwtspaflgallggavllalallrsrr 272
Cdd:cd17474   159 AALIPVAFLAILFLLPEpkEKAKSSSATKLRDLKKALRGRGLLTFLVS-------------------------------- 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 273 hpapaveislwrsrkfrVANIAFVLFGGsmycwLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRY--ARAHQ 350
Cdd:cd17474   207 -----------------AFLYFFLYFAF-----LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlkKRFGA 264

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023668590 351 RVAVVVGGILFAvqcgIWMIGLESKPDFLVIWLPaTLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:cd17474   265 RRILVIGLLLYA----LSLLLLGFVPSLALLLIA-IVLFGLGLGLNLPLLTTLVTELAPEE 320
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 55-409 5.39e-22

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 97.26  E-value: 5.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  55 AFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGI 134
Cdd:cd17320    21 ALPAIARDL-GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 135 SAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPPRTG 214
Cdd:cd17320   100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 215 PAGRMPDLIGTLAVALgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapaveiSLWRSRKFRVANIA 294
Cdd:cd17320   180 EEKRKPLLSSLLRAYK--------------------------------------------------RVLKNRRFLGYALA 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 295 FVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGILFAVQCGIWMIGLES 374
Cdd:cd17320   210 LGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAL 289

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2023668590 375 K--PDFLVIWLPATLIGGvGIGAVMTGLSSASATALP 409
Cdd:cd17320   290 LggLSLWPLVAPLFLIFF-GFGLIFPNATSLALEPFP 325
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
30-209 5.98e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 96.86  E-value: 5.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  30 RGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGF 109
Cdd:COG2271     7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 110 TLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPS 189
Cdd:COG2271    86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165

                         170       180
                  ....*....|....*....|
gi 2023668590 190 VFLINVPLGVMLVVASYRIL 209
Cdd:COG2271   166 AFLILGLPGLLLALLRFWLL 185
PRK14995 PRK14995
SmvA family efflux MFS transporter;
47-410 4.01e-20

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 92.87  E-value: 4.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  47 LDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLV 126
Cdd:PRK14995   20 IDATVLHVAAPTLSMTL-GASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 127 GMRVLQGISAAGMIPSALSLVLSS-RPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVAS 205
Cdd:PRK14995   99 ATRALLAIGAAMIVPATLAGIRATfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 206 YRILPPRTG----PAGRMPDLIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALallrSRRHPAPAVEIS 281
Cdd:PRK14995  179 ARYVPRQAGrrdqPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT----QLAASRPMIDMR 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 282 LWrsrKFRVANIAFVLFGGSMYCWLLAAPLFATE---IWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGG 358
Cdd:PRK14995  255 LF---THRIILSGVVMAMTAMITLVGFELLMAQElqfVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGG 331

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2023668590 359 ILFavqCGIWMIGLeSKPDFLV-IWLPATLIGGVGIGAVMTGLSSASA--TALPP 410
Cdd:PRK14995  332 MAL---SALSFYGL-AMTDFSTqQWQAWGLMALLGFSAASALLASTSAimAAAPP 382
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 44-411 9.68e-20

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 90.71  E-value: 9.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  44 VAFLDVSVTYV------AFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCA 117
Cdd:cd17504     1 LALAALAVMLVetmlspALPTIQREF-GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 118 IAPTVEFLVGMRVLQGISAAgMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPL 197
Cdd:cd17504    80 FAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 198 GVMLVVAsyrilpprtgpagrmpdligtlavalgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpAPA 277
Cdd:cd17504   159 AVLLAAL----------------------------------------------------------------------VPL 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 278 VEISLWRSRKFRVANIAFVLFGGSMYCWLLAAP-LFATEIW---GYSEVQAGLALAPGAVMSVIASVLAGRYARAH-QRV 352
Cdd:cd17504   169 IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPqLLQLPTPtgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVgPRR 248

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 353 AVVVGGILFAVQCGIWMIglesKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:cd17504   249 VLLIGLVISAVGLLLLAL----LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPD 303
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 34-409 4.50e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 88.76  E-value: 4.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  34 TLLMACGAtFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLAS 113
Cdd:cd17324     1 LLALALAA-FAIGTTEYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 114 GLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:cd17324    79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 194 NVPLGVMLVVASYRILPPRTGPAGRMPDLIGTLAvalgvggvvaaltegsswgwtspaflgallggavllalallrsrrh 273
Cdd:cd17324   159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLL---------------------------------------------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 274 papaveiSLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVA 353
Cdd:cd17324   193 -------LLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2023668590 354 VVVGGILFAVqCGIWMIGLESKPDFLVIwlpATLIGGVGIGAVMTGLSSASATALP 409
Cdd:cd17324   266 LLIALLLLAA-ALLLLTLLGPSPLLLLV---GLVLWGLGFFAAHSALQTRVLRLAP 317
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
33-396 2.03e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 83.78  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  33 LTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLA 112
Cdd:COG2223     5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 113 SGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFL 192
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 193 IN-VPLGVMLVVASYRILPPRTGPAGRMPDLIGTLAVALgvggvvaaltegsswgwtspaflgallggavllalallrsr 271
Cdd:COG2223   164 ILgILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL----------------------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 272 rhpapaveislwRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYA-RAHQ 350
Cdd:COG2223   203 ------------RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSdRIGG 270

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2023668590 351 RVAVVVGGILFAVQCGIWMIGLESKPDFLVIWLPATLIGGVGIGAV 396
Cdd:COG2223   271 RRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 38-215 4.66e-17

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 82.31  E-value: 4.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  38 ACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCA 117
Cdd:cd17476     3 ISGAQLLNQAGLGSVIVILPIIGDSF-GTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 118 IAPTVEFLVGMRVLQGISAAGMIPSALSLVLSS-RPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVP 196
Cdd:cd17476    82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTyPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAI 161

                         170
                  ....*....|....*....
gi 2023668590 197 LGVMLVVASYRILPPRTGP 215
Cdd:cd17476   162 LAAIVAVAAIFWTSPSFIA 180
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 35-210 9.04e-17

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 81.46  E-value: 9.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASG 114
Cdd:cd17319     5 IPLLFLAYVINYLDRVNISVAAPTIMKDL-GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 115 LCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLIN 194
Cdd:cd17319    84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIE 163

                         170
                  ....*....|....*.
gi 2023668590 195 VPLGVMLVVASYRILP 210
Cdd:cd17319   164 GLLGLLLAVLWWFYLR 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-209 9.47e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.69  E-value: 9.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590   6 AAAQLVPPKTTAPPPDTGQDAAYARGGL-------TLLMACGATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSY 78
Cdd:cd17325   165 VLALLLLPEPRPPPNKRAVSAARLRSGLrlllrdrRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  79 TVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSS 158
Cdd:cd17325   245 GLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2023668590 159 AIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRIL 209
Cdd:cd17325   325 AMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 34-410 1.71e-14

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 75.11  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  34 TLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLAS 113
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADL-STPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 114 GLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 194 NVPLGVMLVVASYRILPPRTGPAGRMpdLIGTLAVALGvggvvaaltegsswgwtspaflgallggavllalallrsrrh 273
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETLPYEARI--QISTYFETFL------------------------------------------ 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 274 papaveiSLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVA 353
Cdd:TIGR00710 201 -------LLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKS 273

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 354 VVVGG--ILFAVQCGIWMIGLESKPDFLVIWLPATLIgGVGIGAVmtgLSSASATALPP 410
Cdd:TIGR00710 274 LLRMGliLFAVSAVLLEITAILGLGSWAMIIGPMMFV-GIGNSMI---SSIAMAYALED 328
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 35-209 4.12e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.40  E-value: 4.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSF-PDASLSALSWVVSSYTVV--FAAVLApaGRLADVMGRRALFLWSVAGFTL 111
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFsLGLSLLQTGLLFAAGFLGrpIGALLF--GYLGDRIGRKKALILTLLLFGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 112 ASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGL----WGASSSAAAAVGPPLGGLLVDSFGW 187
Cdd:cd17316    79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGW 158

                         170       180
                  ....*....|....*....|..
gi 2023668590 188 PSVFLINVPLGVMLVVASYRIL 209
Cdd:cd17316   159 RILFLIGALPALLALLLRRRTL 180
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 62-204 6.83e-14

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 73.07  E-value: 6.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  62 SFPDASLSALSWVVSSYTVVFAAVLAPA-GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGIsAAGMI 140
Cdd:cd17391    28 VTSGGLVELWSGLAFSSTFLVSAIFSPIwGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYV 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023668590 141 PSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLInvpLGVMLVVA 204
Cdd:cd17391   107 PNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI---TGGLLFLA 167
2_A_01_02 TIGR00880
Multidrug resistance protein;
72-211 1.02e-13

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 68.06  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  72 SWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSR 151
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 152 PPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPP 211
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 38-411 1.06e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.46  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  38 ACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCA 117
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 118 IAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVD--SFGWPSVFLINV 195
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 196 PLGVMLVVASYRILPPRTGPAGRMPDLIGTLAVALGVGgvvaaltegsswgwtspaflgallggavllalallrsrrhpa 275
Cdd:cd06174   160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK------------------------------------------ 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 276 paveiSLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYA-RAHQRVAV 354
Cdd:cd06174   198 -----RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPL 272

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2023668590 355 VVGGILFAVQCGIWMIGLESKPDFLVIwlpaTLIGGVGIGAVMTGLSSASATALPPR 411
Cdd:cd06174   273 LLIGLLLMALGLALLLLAPSLLLLLLL----LLLLGFGLGGLLPLSFALIAELFPPE 325
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 30-210 6.54e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 70.08  E-value: 6.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  30 RGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSS--YTVVFAAVLApaGRLADVMGRRALFLWSVA 107
Cdd:TIGR00895  14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEW-GLDPVQLGFLFSAglIGMAFGALFF--GPLADRIGRRRVLLWSIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 108 GFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGW 187
Cdd:TIGR00895  91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170

                         170       180
                  ....*....|....*....|...
gi 2023668590 188 PSVFLINVPLGVMLVVASYRILP 210
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFLP 193
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 39-412 6.93e-13

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 70.73  E-value: 6.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  39 CGATFVAFLDVSVTYVAFPSLHKSFPDASLSAlsWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAI 118
Cdd:cd06179     4 CLAYFAQLFGVTLPAAVLPFIVADLGPSSNST--WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 119 APTVEFLVGMRVLQGISAA--GMIPSALSLVLssrPPEHRSSAIGLWGASSSAAAAVGPPLGGLLV--DSFGWPSVFLIN 194
Cdd:cd06179    82 AKSVNMLIGGQALIGIGAGtqGLGAAVASELV---PNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYIN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 195 VPLGVM---LVVASYRiLPPRTGPAGRMP-------DLIGTLAVALGVGGVVAALT-EGSSWGWTSPAFLGALLGGAVLL 263
Cdd:cd06179   159 AIFNALaliLLFFFYH-PPPRPQLHGSSTrqklkrlDWVGLFLLIAGLVLFLLGLSwGGNPYPWSSAHVIAPLVIGGVLL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 264 ALALLR----SRRHPAPAVEISLWRsrkfRVANIAFVLF-GGSMYCWLLAA-PLFATEIWGYSEVQAGLALAPGAVMSVI 337
Cdd:cd06179   238 IAFGLYewkgTKDGLLPPRLLFRGR----NFALILIVAFvEGMIFYSLNIFwPQQISLLFTTDPLKAGLYQLPFGLGTLF 313

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2023668590 338 ASVLAGRYARA--HQRVAVVVGGILFAVQCGIWMIgleSKPDFLVIWLPATLIGGVGIGAVMTGLSSASATALPPRL 412
Cdd:cd06179   314 GAILAGLLLTKikHIKWQLVAGFVLFTAFLALLAL---ITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPED 387
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 35-204 4.75e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 67.23  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASG 114
Cdd:cd17365     1 LALCFLIIVLDGFDLAVMGFVAPALAQDW-GLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 115 LCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLIN 194
Cdd:cd17365    80 LTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLG 159

                         170
                  ....*....|
gi 2023668590 195 VPLGVMLVVA 204
Cdd:cd17365   160 GVPPLILLPL 169
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 55-412 3.51e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 64.52  E-value: 3.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  55 AFPSLHKSFPDASLSALSWVVSSYTVvFAAVLAP-AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQG 133
Cdd:cd17473    21 ALPAIAQHFVPNSELLVPLLLTLPAL-FIALFAPlAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 134 ISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDsFGWPSVFLINVpLGVMLVVASYRILPPRT 213
Cdd:cd17473   100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 214 GPAGRMPDLIGTLAVALgvggvvaaltegsswgwtspaflgallggavllalallrsrrhpapaveislwrsRKFRVANI 293
Cdd:cd17473   178 RKSKSAASPGAATAAAL-------------------------------------------------------PWKRVLPI 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 294 AFVLFGGSM--YCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAH-QRVAVVVGGILFAVqcGIWMI 370
Cdd:cd17473   203 YFLAFLAMLlfYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLgKRRLLAIGFALMAL--GFLLL 280

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2023668590 371 GLESkpdFLVIWLPATLIGGVGIGAVMTGLSSASATALPPRL 412
Cdd:cd17473   281 ALAS---GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPEL 319
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 74-211 1.76e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 62.61  E-value: 1.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  74 VVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPP 153
Cdd:cd17489    36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2023668590 154 EHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPP 211
Cdd:cd17489   116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 35-211 3.76e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 61.44  E-value: 3.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAA---VLAPagrLADVMGRRALFLWSVAGFTL 111
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDF-HVSEEVANLGVSLFVLGFGLgplIWAP---LSELYGRRPVYLVSLFIFVI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 112 ASGLCAIAPTVEFLVGMRVLQGISAAgmipSALSLVLSSR----PPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGW 187
Cdd:cd17323    77 FQIGCALAPNIAMLIILRFLQGFFGS----SPLAIGAGTIadlfTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152

                         170       180
                  ....*....|....*....|....
gi 2023668590 188 PSVFLINVPLGVMLVVASYRILPP 211
Cdd:cd17323   153 RWIFWFLAIISGFCLILIFLFLPI 176
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 51-211 1.04e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 56.82  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  51 VTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRV 130
Cdd:cd17330    16 FPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 131 LQGISAAGmIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILP 210
Cdd:cd17330    96 LDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174


                  .
gi 2023668590 211 P 211
Cdd:cd17330   175 P 175
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
67-398 2.06e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 56.03  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  67 SLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGIsAAGMIPSALSL 146
Cdd:COG2807    51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-GIAVGNVLLPG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 147 VLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPsvflinvplgvmlvvasyrilpprtgpagrmpdligtl 226
Cdd:COG2807   130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR-------------------------------------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 227 aVALGVGGVVAALTegsswgwtspaflgaLLGGAVLLALALLRSRRHPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWL 306
Cdd:COG2807   172 -GALAVWALLALLA---------------LLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 307 LAAPLFATEIwGYSEVQAGLALAPGAVMSVIASVLAGRYAR--AHQRVAVVVGGILFAVQCGIWMIGleskPDFLviWLP 384
Cdd:COG2807   236 AWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADrlGDRRPLLLLLGLLGLAGLLGLLLA----PGSL--PWL 308

                         330
                  ....*....|....
gi 2023668590 385 ATLIGGVGIGAVMT 398
Cdd:COG2807   309 WAVLLGLGQGGLFP 322
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 41-412 4.21e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 55.31  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:cd06173     7 AQLLSALGDWIFTVALPWLVLQL-TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 121 -----TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINV 195
Cdd:cd06173    86 llgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 196 PLGVMLVVASYRILPPRTGPAGRMPDLIGTLAVALGvggvvaaltegsswgwtspaflgallggavllalallrsrrhpa 275
Cdd:cd06173   166 LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGL-------------------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 276 paveISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVV 355
Cdd:cd06173   202 ----RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLL 277

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2023668590 356 VGGILFavqCGIWMIGLESKPDFLVIwLPATLIGGVGIGAVMTGLSSASATALPPRL 412
Cdd:cd06173   278 LIGALL---LGLALLVLGLSPSLWLL-LAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 52-229 7.19e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 54.53  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  52 TYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFT-LASGLCAIAPTVEFLVGMRV 130
Cdd:cd17490    14 VYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 131 LQGISAAGMIpSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILP 210
Cdd:cd17490    94 LSGIAAATWV-SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKE 172

                         170
                  ....*....|....*....
gi 2023668590 211 PRTGPAGRMPDLIGTLAVA 229
Cdd:cd17490   173 ERREKKPVLTELKELLSVL 191
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 41-211 1.63e-07

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 53.33  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLC--AI 118
Cdd:cd17380     7 ATCICYADRVNMPIAIVPMAKEF-GWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 119 APTVEFLVGMRVLQGIsAAGMIPSALSLVLSSRPPEH-RSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPL 197
Cdd:cd17380    86 YSSLPLLILSRILLGL-GEGVHFPSMTSLFSRWVPVSeRSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLL 164

                         170
                  ....*....|....
gi 2023668590 198 GVMLVVASYRILPP 211
Cdd:cd17380   165 GLLWALVWLIYLPP 178
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
66-193 1.63e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 53.39  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  66 ASLSALSWVVSSYTVVFAAVLAPA-GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGIsAAGMIPSAL 144
Cdd:PRK09874   50 SALNMWSGLVFSITFLFSAIASPFwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNAN 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023668590 145 SLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:PRK09874  129 ALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFI 177
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 88-211 1.96e-07

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 53.01  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  88 PAGRLADVMGRRALFLWSVAG---FTLASGLCAIApTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWG 164
Cdd:cd17318    75 PGGYLAEKYGAKRVLGYSILItalLTLLTPLAARG-GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2023668590 165 ASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPP 211
Cdd:cd17318   154 SGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLP 200
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 80-225 2.22e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.01  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  80 VVFAAVLAP-AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSS 158
Cdd:cd17328    44 IISYMVLSPiFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 159 AIGLWGASSSAAAAVGPPLGGLLVDSF-GWPSVFLINVPLGVMLVVASYRILP-PRTGPAGRMPDLIGT 225
Cdd:cd17328   124 ALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVRePPRGAAEGGVMAKST 192
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 26-220 4.25e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 51.89  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  26 AAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWS 105
Cdd:PRK11551    8 ASSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQEF-GLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 106 VAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLwgasssaaAAVGPPLGGLL---- 181
Cdd:PRK11551   87 VALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSL--------MYCGVPFGGALasvi 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 182 ----VDSFGWPSVF-------LINVPLGVMLVVASYRILPPRTGPAGRMP 220
Cdd:PRK11551  159 gvlaAGDAAWRHIFyvggvgpLLLVPLLMRWLPESRAFAQAAGAGKQRAP 208
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-164 8.68e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 8.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590   6 AAAQLVPPKTTAPPPDTGQDAAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAV 85
Cdd:COG2814   180 LLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590  86 LAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWG 164
Cdd:COG2814   260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
55-243 1.11e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 50.68  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  55 AFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGI 134
Cdd:PRK11102   13 ALPVIAADF-GVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 135 SAA--GMIPSALSLVLSSRPPEHRS-SAIGLwgaSSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPP 211
Cdd:PRK11102   92 AAAaaSVVINALMRDMFPKEEFSRMmSFVTL---VMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 212 RTGPAGRMPDLIGT------------------LAVALGVGGVVAALTEGS 243
Cdd:PRK11102  169 TLPKERRQPFHLRTtirnfaslfrhkrvlgymLASGFSFAGMFSFLTAGP 218
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 35-232 1.54e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 50.35  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASG 114
Cdd:cd17355     5 LAVTFLILILSWGIRYYFGVFIIPIIAEF-GWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 115 LCAIAPTV-EFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:cd17355    84 LLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2023668590 194 NVPLGVMLVVASYRILPPRTGPAGRMPDLIGTLAVALGV 232
Cdd:cd17355   164 LALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGST 202
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 89-195 2.13e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  89 AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGL----WG 164
Cdd:cd17371    54 GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWA 133

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2023668590 165 ASSSAAAAVGPPLGGLLVDSFGWPSVFLINV 195
Cdd:cd17371   134 VGWLLATLLAALLFPLLPPEIAWRVLFLLGA 164
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
31-212 2.86e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.47  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  31 GGLTLLMACGAtFVAFLDVSVTYVafpslhKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFT 110
Cdd:COG0738   215 GGLAIFLYVGA-EGAIGDWLPLYL------KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 111 LASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSsRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSV 190
Cdd:COG0738   288 VGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD-GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAA 366

                         170       180
                  ....*....|....*....|..
gi 2023668590 191 FLINVPLGVMLVVASYRILPPR 212
Cdd:COG0738   367 FLVPLVCYLLILLLALALKRKR 388
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 65-246 5.36e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 48.32  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  65 DASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSAL 144
Cdd:cd17477    27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 145 SLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGlLVDSFGWPSVFLINV--PLGVMLVVASYRILPPRTGPAGRMPDL 222
Cdd:cd17477   107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVllLLALVPLLLTRRAAPEIEEAESISLRR 185

                         170       180
                  ....*....|....*....|....
gi 2023668590 223 IGTLAVALGVGGVVAALTEGSSWG 246
Cdd:cd17477   186 LLRIAPLALLGAFVAGFLEGAFYS 209
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 7-208 5.66e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 5.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590   7 AAQLVPPKTTAPPPDTGQDAAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVL 86
Cdd:cd06173   182 PPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  87 APAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGAS 166
Cdd:cd06173   262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2023668590 167 SSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRI 208
Cdd:cd06173   342 NSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
222-402 6.64e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 222 LIGTLAVALGVGGVVAALTEGSSWGWTSPAFLGALLGGAVLLALALLRSRRHPAPAVEISLWRS-------RKFRVANIA 294
Cdd:COG2211   157 GLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESlkallknRPFLLLLLA 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 295 FVLFGGSMYCWLLAAPLFATEIWGYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGILFAVQCGIWMIGLes 374
Cdd:COG2211   237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL-- 314

                         170       180
                  ....*....|....*....|....*...
gi 2023668590 375 KPDFLVIWLPATLIGGVGIGAVMTGLSS 402
Cdd:COG2211   315 GPGNLWLLLVLAALAGIGLGAILVLPWA 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 71-157 1.16e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.19  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  71 LSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSS 150
Cdd:cd17317    27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106


                  ....*..
gi 2023668590 151 RPPEHRS 157
Cdd:cd17317   107 VGPKYRS 113
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
66-209 1.60e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 46.94  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  66 ASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVE-FLVGmRVLQGISAAGMIPSAL 144
Cdd:PRK10473   35 ASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSlFLAG-RFLQGIGAGCCYVVAF 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023668590 145 SLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRIL 209
Cdd:PRK10473  114 AILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFIL 178
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 36-162 1.79e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 46.79  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  36 LMACGATFVAFL---DVSVTYVAFPSLHKSFPDASLsALSWVVSSYTV--VFAAVLApaGRLADVMGRRALFLWSVAGFT 110
Cdd:cd17359     1 LISLVAALGGLLfgyDTGVINGALPFLQTDFNLTPF-LEGLVVSSALLgaAIGALFA--GRLADRFGRRKTLLISAVLFF 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2023668590 111 LASGLCAIAPTVEFLVGMRVLQGI---SAAGMIPSALSLVlssRPPEHRSSAIGL 162
Cdd:cd17359    78 ISALGSAFSPNFTIFIIARIIGGLavgGASALVPMYIAEV---APAEIRGRLVSL 129
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-249 2.30e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  33 LTLLMACGATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLA 112
Cdd:COG0738     8 RALIAIYLLFFLWGFATALWGPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 113 SGLCAIAPTVEFLVGMRVLQGIsAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVD---SFGWPS 189
Cdd:COG0738    87 LLLFALAPSYPLLLLALFLLGL-GLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHL 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023668590 190 VFLIN-VPLGVMLVVASYRILPPRTGPAGRMPDLIGTLA--------VALGVGGVVAALTEGSSWGWTS 249
Cdd:COG0738   166 PYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKsllknprlLLGGLAIFLYVGAEGAIGDWLP 234
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 90-162 2.49e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 46.13  E-value: 2.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023668590  90 GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGL 162
Cdd:cd17374    56 GHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITL 128
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 48-134 2.87e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 46.11  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  48 DVSVTYVAFPSLHKSFPDASLSA-LSWVVSSYTVVFAAVLAP-AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFL 125
Cdd:cd17360    12 DTGVISGALLYIKDDLGEVVLSTgWQELIVSSTVAGAAVGAAiGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91


                  ....*....
gi 2023668590 126 VGMRVLQGI 134
Cdd:cd17360    92 IVGRVLVGL 100
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 12-205 3.32e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.03  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  12 PPKTTAPPPDTGQDAAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGR 91
Cdd:cd17473   176 PARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGR 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  92 LADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAA 171
Cdd:cd17473   256 LKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2023668590 172 AVGPPLGGLLVDSFGWPS-VFLInvpLGVMLVVAS 205
Cdd:cd17473   336 FLSPLVLGPLVNLTGGLSgAFLI---LGVLALVLA 367
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 88-212 4.48e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 45.67  E-value: 4.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  88 PAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQG---ISAAGMipsalSLVLSSRPPEHRSSAIGLWG 164
Cdd:cd17472    51 PFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGsgaISSVVM-----ALLADLTREENRTKAMALIG 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 165 ASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGV--MLVVASYRILPPR 212
Cdd:cd17472   126 ASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLvsLLILLFFVPDPPK 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 67-224 4.61e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  67 SLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSL 146
Cdd:cd17329    33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 147 VLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVD-SFGWPSVFLINVPLGVMLVVAS-YRILPPRTGPAGRMPDLIG 224
Cdd:cd17329   113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLySFRLLFLAAAVLFLLAALVLLFlLPETRPKRRAAEKTEILRG 192
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-189 7.14e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 7.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  12 PPKTTAPPPDTGQDAAYARGGLTLLMACGATFVAFLDVSVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGR 91
Cdd:COG2211   207 RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  92 LADVMGRRALFLWSVAGFTLASGLCAIAP--TVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSS-------AIGL 162
Cdd:COG2211   287 LAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGI 366

                         170       180
                  ....*....|....*....|....*..
gi 2023668590 163 WGASSSAAAAVGPPLGGLLVDSFGWPS 189
Cdd:COG2211   367 FTFAIKLGQALAGALAGLLLALFGYVA 393
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 80-181 7.42e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 44.93  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  80 VVFAAVLapaGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMiPSALSLVLSSRPPEHRSSA 159
Cdd:cd17388    52 FIFAPIL---GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARN 127

                          90       100
                  ....*....|....*....|..
gi 2023668590 160 IGLWGASSSAAAAVGPPLGGLL 181
Cdd:cd17388   128 FGLLGAAFGLGFIAGPALGGLL 149
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 90-406 7.81e-05

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 44.90  E-value: 7.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  90 GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRV----LQGISAAGMIPSALSlvlssrPPEHRSSAIGLWGA 165
Cdd:cd17331    56 GRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLpsvfMHAMQAAQMVVTDLT------DPGERAAALGRLGL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 166 SSSAAAAVGPPLGGLLVDSFGwpsvflinvPLGVMLVVAsyrilpprtgpagrmpdlIGTLAVALGVGGVVAALTEGSSW 245
Cdd:cd17331   130 SYGIGMVVGSFLGGLLTKKFG---------EQAAALVAA------------------VGSLLSIVLVILLIPSNTKSKRE 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 246 gwtspaflgallggavllalalLRSRRHPAPAVEISLWRSRK-FRVANIAFVLF-----GGSMYCWLLAAPLFATEIWGY 319
Cdd:cd17331   183 ----------------------KEAKESASPPSVFNLKEILRlLRLPGVAFLLLvkllsGLPIGMFQSMFSLVAMDFFGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 320 SEVQAGLALAPGAVMSVIA-SVLAGRYARAHQRVAVVVGGILFAVQCGIWMIGLESKPDFLVIWLPATLIG---GVGIGA 395
Cdd:cd17331   241 TPEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGsvlYTVITS 320

                         330
                  ....*....|.
gi 2023668590 396 VMTGLSSASAT 406
Cdd:cd17331   321 LLTKAVPPEDT 331
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 66-207 1.25e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 44.13  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  66 ASLSALSWVVSSYTVVFAAVLAPAGRLA-DVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSAL 144
Cdd:cd17490   227 ASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLM 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023668590 145 SLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYR 207
Cdd:cd17490   307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 38-163 1.25e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.10  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  38 ACGATFVAFLDVSVTYVAFPSLHKSFPDASLSAL-SWVVSSyTVVFAAVLA-PAGRLADVMGRRALFLWSVAGFTLASGL 115
Cdd:cd17315     2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLqGLVVSS-LLLGAAIGSlFGGPLADRFGRRKSLLIAAVLYVIGALL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023668590 116 CAIAPTVEFLVGMRVLQGIsAAGMIPSALSLVLS-SRPPEHRSSAIGLW 163
Cdd:cd17315    81 SALAPNVWVLIVGRFLLGL-GVGLASVLVPLYISeIAPAKIRGALGTLN 128
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 70-220 4.73e-04

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 42.43  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  70 ALSWVVSSYTVVFAAVlaPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP-----TVEFLVGMRVLQGISAAGMIPSAL 144
Cdd:pfam05977  48 ALVQAAATLPIFLLSI--PAGALADNFDRRKIMLAGQLLLALVSTLLTLLAglgllSPWLLLGLTFLGGIGTALMDPAWQ 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2023668590 145 SLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRIlpPRTGPAGRMP 220
Cdd:pfam05977 126 ASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRW--KRAAPASPLP 199
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 90-411 7.11e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  90 GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVE--------FLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRssaiG 161
Cdd:cd17369    65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAqigilapiLLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR----G 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 162 LWGASSSaaaaVGPPLGGLLvdsfgwpsvflinvPLGVMLVVASyriLPPR---TGPAGRMPDLIGtlAVALGVGGVV-A 237
Cdd:cd17369   141 FYGSFPQ----LGAPVGLLL--------------ATGVFLLLSA---LLSDeafLSWGWRIPFLLS--AVLVAVGLYIrL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 238 ALTEgsswgwtSPAFLGALLggavllalallRSRRHPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIW 317
Cdd:cd17369   198 RLEE-------TPVFRRAKE-----------AGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 318 GYSEVQAGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGILFAVQCGIWMIGLESKPDFLVIWLPATLIGGVGIGAVM 397
Cdd:cd17369   260 GVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMY 339

                         330
                  ....*....|....
gi 2023668590 398 TGLSSASATALPPR 411
Cdd:cd17369   340 GPQAAFLAELFPTR 353
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 79-156 1.08e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  79 TVVFAAVLAPA---GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEH 155
Cdd:TIGR00898 134 SCFFVGVLLGSfvfGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213


                  .
gi 2023668590 156 R 156
Cdd:TIGR00898 214 R 214
Sugar_tr pfam00083
Sugar (and other) transporter;
50-163 1.38e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.10  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  50 SVTYVAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP---TVEFLV 126
Cdd:pfam00083  27 DFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLI 106

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2023668590 127 GMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLW 163
Cdd:pfam00083 107 VGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLY 143
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 90-193 1.38e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.22  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  90 GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSA 169
Cdd:PRK03893   76 GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSI 155

                          90       100
                  ....*....|....*....|....
gi 2023668590 170 AAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:PRK03893  156 GAVVAAQVYSLVVPVWGWRALFFI 179
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 30-191 1.55e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.69  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  30 RGGLTLLMACGATFVAFLDVSVTYVAF--------PSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRAL 101
Cdd:cd17313   234 RSLLRLLLVIFFWWIAFFPFELFFTDYmgeevyhgTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKV 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 102 FLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRS--SAIGLWGASSSAAAAVGPPLGG 179
Cdd:cd17313   314 YLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGqgTDTGLLNLAISLAQILVSLLAG 393

                         170
                  ....*....|..
gi 2023668590 180 LLVDSFGWPSVF 191
Cdd:cd17313   394 PIIDVKGYGTVF 405
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 42-193 1.62e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  42 TFVAFLDVSVTYVAFPSLH--KSFPDASLSALSWVVssYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIA 119
Cdd:cd17370   207 LAVALFALGNFSFAFLILRaqELGLSAALIPLLYAL--FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG 284

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023668590 120 PTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:cd17370   285 SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
PRK12307 PRK12307
MFS transporter;
90-203 1.70e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 40.68  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  90 GRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSA 169
Cdd:PRK12307   74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2023668590 170 AAAVGPPLGGLLVDSFGWPSVFLINVpLGVMLVV 203
Cdd:PRK12307  154 GNIIAAYFMPSFAEAYGWRAAFFVGL-LPVLLVI 186
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 68-193 2.65e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.94  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  68 LSALSWVVSSYTVVFAAVLAP-AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSL 146
Cdd:cd17391   238 LAFISGLVFSATGVSSLLSAPrLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSL 317

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2023668590 147 VLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLI 193
Cdd:cd17391   318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-216 2.89e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  35 LLMACGATFVAFLDVSVtyvAFPSLHKSFPDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASG 114
Cdd:COG2223   210 LSLLYFGTFGSFIGFSS---WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 115 LCAIAPT--VEFLVGMRVLqGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFG-WPSVF 191
Cdd:COG2223   287 LLALALGslWLFLVLFLLL-GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAF 365

                         170       180
                  ....*....|....*....|....*
gi 2023668590 192 LINVPLGVMLVVASYRILPPRTGPA 216
Cdd:COG2223   366 LVFAVLALVALVLTLLLYRRPRRAA 390
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 73-200 3.87e-03

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 39.38  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  73 WVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAPT--VEFLVGMRVLQGISAAGMIPSALSLVLSS 150
Cdd:cd17381    69 WILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADlgAGYLIAVRALEGLGEGVTFPAMHAMWASW 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2023668590 151 RPPEHRSSAIGLWGASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVM 200
Cdd:cd17381   149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLL 198
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 90-393 3.98e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  90 GRLADV-MGRRALFLWSVAGFTLASGLCAIAPT--VEFLVGMrVLQGISAAGMiPSALSL---VLSSRPPEHRSSAIGLW 163
Cdd:cd17471    53 GRLSDRgGDRKPLILLALLAGALGYLLFAFLRNywVLLLVGV-VLLSLGAAAF-PQLFALareYADRSSGRDATLFNSVL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 164 GASSSAAAAVGPPLGGLLVDSFGWPSVFLINVPLGVMLVVASYRILPPRTGPAGrmpdligtlavalgvggvvaaltegs 243
Cdd:cd17471   131 RAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ-------------------------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590 244 swgwtspaflgallggavllalallrsrRHPAPAVEISLWRSRKFRVANIAFVLFGGSMYCWLLAAPLFATEIWGYSEVQ 323
Cdd:cd17471   185 ----------------------------KATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESW 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023668590 324 AGLALAPGAVMSVIASVLAGRYARAHQRVAVVVGGILFAVQCGIWMIGLESKPDFLVI-WLPATLIG---GVGI 393
Cdd:cd17471   237 VGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALqLLNAIFIGitaGLGI 310
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 89-204 4.32e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.51  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  89 AGRLADVMGRRALFLWSVAGFTLASGLCAIAPTVEFLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSS 168
Cdd:cd17331   264 VGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFS 343

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2023668590 169 AAAAVGPPLGGLLVDSFGWPSVFLIN-VPLGVMLVVA 204
Cdd:cd17331   344 LVRTVSPTIGGALLQAYGFPSFGLLGaAINGLLTVYL 380
MFS_1 pfam07690
Major Facilitator Superfamily;
41-175 9.93e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023668590  41 ATFVAFLDVSVTYVAFPSLHKSFpDASLSALSWVVSSYTVVFAAVLAPAGRLADVMGRRALFLWSVAGFTLASGLCAIAP 120
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2023668590 121 TVE---FLVGMRVLQGISAAGMIPSALSLVLSSRPPEHRSSAIGLWGASSSAAAAVGP 175
Cdd:pfam07690 287 LTLsslWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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