|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
11-314 |
6.44e-160 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 448.98 E-value: 6.44e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLLRADA-S 89
Cdd:cd19152 1 PKLGFGTAPLGNLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELGREDYVISTKVGRLLVPLQeV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKHGPFVKGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEVFDTAMKGAAVALTKLREEG 169
Cdd:cd19152 81 EPTFEPGFWNPLPFDAVFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEHFAQAIKGAFRALEELREEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNF---EYQEA 246
Cdd:cd19152 161 VIKAIGLGVNDWEVILRILEEADLDWVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAGGDNFdyyEYGPA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023934258 247 SPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19152 241 PPELIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLATEIPAAFWEEL 308
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
12-314 |
2.34e-134 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 383.98 E-value: 2.34e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLLR-ADASK 90
Cdd:cd19161 2 ELGLGTAGLGNLYTAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKPRDEFVLSTKVGRLLKpAREGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 GGKHGPFVKGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEV-FDTAMKGAAVALTKLREEG 169
Cdd:cd19161 82 VPDPNGFVDPLPFEIVYDYSYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRKERHhFAQLMSGGFKALEELKKAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIA----GGKNFEYQE 245
Cdd:cd19161 162 VIKAFGLGVNEVQICLEALDEADLDCFLLAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILAtgtkSGAKFNYGD 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 246 ASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19161 242 APAEIISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEAFQTDIPEELWQAL 310
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
13-314 |
1.11e-106 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 313.14 E-value: 1.11e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGNMFEeVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLLRAdaskgg 92
Cdd:cd19162 3 LGLGAASLGNLAR-AGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHPRAEYVVSTKVGRLLEP------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 khGPFVKGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDahgdrwlevFDTAMKGAAVALTKLREEGVIR 172
Cdd:cd19162 76 --GAAGRPAGADRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRH---------LLQALTDAFPALEELRAEGVVG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 173 AWGLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIA----GGKNFEYQEASP 248
Cdd:cd19162 145 AIGVGVTDWAALLRAARRADVDVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILAtddpAGDRYDYRPATP 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 249 DKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19162 225 EVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAEFWAEL 290
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
12-311 |
7.03e-90 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 269.81 E-value: 7.03e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRNYPRDEFVLSTKVGRLlradaskg 91
Cdd:cd19090 2 ALGLGTAGLGGVFGGVDDDEAVATIRAALDLGINYIDTAPAYGD--SEERLGLALAELPREPLVLSTKVGRL-------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkglpFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDrwlevfdTAMKGAAV-ALTKLREEGV 170
Cdd:cd19090 72 -----------PEDTADYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVD-------ILAPGGALeALLELKEEGL 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGK----NFEYQEA 246
Cdd:cd19090 134 IKHIGLGGGPPDLLRRAIETGDFDVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPpervRYTYRWL 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 247 SPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFW 311
Cdd:cd19090 214 SPELLDRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGPLPEELW 278
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
12-316 |
1.25e-85 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 260.50 E-value: 1.25e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLLRADAskg 91
Cdd:COG0667 15 RLGLGTMTFGGPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRPRDDVVIATKVGRRMGPGP--- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkglpfrVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEvfdtamkgaavALTKLREEGVI 171
Cdd:COG0667 92 -------------NGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLG-----------ALDELVREGKI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 172 RAWGLGVNRVEPCVMALERAD--PDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG------------ 237
Cdd:COG0667 148 RYIGVSNYSAEQLRRALAIAEglPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGkyrrgatfpegd 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 238 --GKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQELK 315
Cdd:COG0667 228 raATNFVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALD 307
|
.
gi 2023934258 316 Q 316
Cdd:COG0667 308 A 308
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
12-308 |
1.68e-62 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 200.47 E-value: 1.68e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLlradaskg 91
Cdd:cd19163 15 KLGFGASPLGGVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGIPRDSYYLATKVGRY-------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCaEdaHGDRWLEVFDTAMKgaavALTKLREEGVI 171
Cdd:cd19163 87 --------GLDPDKMFDFSAERITKSVEESLKRLGLDYIDIIQVHDI-E--FAPSLDQILNETLP----ALQKLKEEGKV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 172 RAWG-----LGVNRVepcVMALERADPDVFLLAGRYSLLNQpALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQEA 246
Cdd:cd19163 152 RFIGitgypLDVLKE---VLERSPVKIDTVLSYCHYTLNDT-SLLELLPFFKEKGVGVINASPLSMGLLTERGPPDWHPA 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 247 SPD-KVAARdRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPA 308
Cdd:cd19163 228 SPEiKEACA-KAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKNLEAAEEPLDA 289
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
13-300 |
2.28e-60 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 193.08 E-value: 2.28e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGNMFE-EVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNyPRDEFVLSTKVGRLLRADaskg 91
Cdd:cd19086 6 IGFGTWGLGGDWWgDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG-RRDKVVIATKFGNRFDGG---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkglpFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAhgDRWLEVFDtamkgaavALTKLREEGVI 171
Cdd:cd19086 81 -----------PERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEV--LDNDELFE--------ALEKLKQEGKI 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 172 RAWGLGVNRVEPCVMALERADPDVFLLAgrYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGgknfeyqeaspdkv 251
Cdd:cd19086 140 RAYGVSVGDPEEALAALRRGGIDVVQVI--YNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTG-------------- 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2023934258 252 aardRLAEianrhgvdlraAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19086 204 ----KLAQ-----------AALRFILSHPAVSTVIPGARSPEQVEENAA 237
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
13-316 |
4.60e-57 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 186.36 E-value: 4.60e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYP--RDEFVLSTKVGrllradask 90
Cdd:pfam00248 1 IGLGTWQLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPvkRDKVVIATKVP--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCaedahgDRWLEVFDTAMkgaavALTKLREEGV 170
Cdd:pfam00248 72 ---------DGDGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP------DPDTPIEETWD-----ALEELKKEGK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQ------ 244
Cdd:pfam00248 132 IRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDkgpger 211
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2023934258 245 -----EASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQELKQ 316
Cdd:pfam00248 212 rrllkKGTPLNLEALEALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDE 288
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
12-300 |
1.05e-50 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 168.57 E-value: 1.05e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRNYPRDEFVLSTKVGRLLRADaskg 91
Cdd:cd19095 2 VLGLGTSGIGRVWGVPSEAEAARLLNTALDLGINLIDTAPAYGR--SEERLGRALAGLRRDDLFIATKVGTHGEGG---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkglpfRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDrwlEVFDTamkgaavaLTKLREEGVI 171
Cdd:cd19095 76 ------------RDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTG---EVLET--------LEDLKAAGKV 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 172 RAwgLGVN-RVEPCVMALERADPDVFLLAgrYSLLNQpALDELFPRCQERGVHVVVGGPynsgiIAGGKNFEYQEASPDK 250
Cdd:cd19095 133 RY--IGVSgDGEELEAAIASGVFDVVQLP--YNVLDR-EEEELLPLAAEAGLGVIVNRP-----LANGRLRRRVRRRPLY 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2023934258 251 VAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19095 203 ADYARRPEFAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLA 252
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
12-314 |
1.12e-46 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 159.61 E-value: 1.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGN-MFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGrlLRADASK 90
Cdd:cd19084 6 RIGLGTWAIGGtWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR-RDDVVIATKCG--LRWDGGK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 GGKHgpfvkglpfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWlevFD--TAMKGAAVALTKLREE 168
Cdd:cd19084 83 GVTK-------------DLSPESIRKEVEQSLRRLQTDYIDLYQIH----------W---PDpnTPIEETAEALEKLKKE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 169 GVIRAWGL---GVNRVEPcvmALERADPDVFLlaGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG----GKNF 241
Cdd:cd19084 137 GKIRYIGVsnfSVEQLEE---ARKYGPIVSLQ--PPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGkykkEPTF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 242 E----------YQ-EASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAF 310
Cdd:cd19084 212 PpddrrsrfpfFRgENFEKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEE 291
|
....
gi 2023934258 311 WQEL 314
Cdd:cd19084 292 LKEI 295
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-300 |
1.73e-42 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 146.86 E-value: 1.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGnmfeEVPDDVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRNYpRDEFVLSTKVGrllradaskgg 92
Cdd:cd19100 14 LGFGGGPLG----RLSQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGR-RDKVFLATKTG----------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 khgpfvkglpfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWlevfdTAMKGAAVALTKLREEGVIR 172
Cdd:cd19100 76 ---------------ARDYEGAKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQV-----FGPGGALEALLEAKEEGKIR 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 173 AWGLGVNRVEPCVMALERADPDVFLLA-GRYSLLNQPALDELFPRCQERGVhvvvggpynsGIIAGgknfeyqeaspdKV 251
Cdd:cd19100 136 FIGISGHSPEVLLRALETGEFDVVLFPiNPAGDHIDSFREELLPLAREKGV----------GVIAM------------KV 193
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2023934258 252 AARDRLAEianrHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19100 194 LAGGRLLS----GDPLDPEQALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
12-302 |
2.68e-42 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 148.77 E-value: 2.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNY--PRDEFVLSTKVGRllradas 89
Cdd:PLN02587 13 SVGFGASPLGSVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALgiPREKYVVSTKCGR------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 kggkhgpFVKGlpfrvdYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCaEDAHgdrwlevFDTAMKGAAVALTKLREEG 169
Cdd:PLN02587 86 -------YGEG------FDFSAERVTKSVDESLARLQLDYVDILHCHDI-EFGS-------LDQIVNETIPALQKLKESG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGVNRVEPCVMALERADP---DVFLLAGRYSlLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQEA 246
Cdd:PLN02587 145 KVRFIGITGLPLAIFTYVLDRVPPgtvDVILSYCHYS-LNDSSLEDLLPYLKSKGVGVISASPLAMGLLTENGPPEWHPA 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 247 SPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLM 302
Cdd:PLN02587 224 PPELKSACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVEENVAAA 279
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
14-314 |
8.48e-42 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 146.58 E-value: 8.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 14 GFGGAPLGnmfEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNyPRDEFVLSTKVGrllradaskgGK 93
Cdd:cd19085 10 QFGGGYWW---GDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG-RRDDVVIATKVS----------PD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 94 HGpfvkglpfrvdydyTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWlEVFDTAMKGAAVALTKLREEGVIRA 173
Cdd:cd19085 76 NL--------------TPEDVRKSCERSLKRLGTDYIDLYQIH----------W-PSSDVPLEETMEALEKLKEEGKIRA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 174 WGL---GVNRVEpcvMALERADPDVFLLAgrYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG------------- 237
Cdd:cd19085 131 IGVsnfGPAQLE---EALDAGRIDSNQLP--YNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTGkfssaedfppgda 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 238 -GKNFEYQE--ASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19085 206 rTRLFRHFEpgAEEETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERL 285
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
12-303 |
1.03e-41 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 146.80 E-value: 1.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLG--NMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGRLLRADAS 89
Cdd:cd19083 13 PIGLGTNAVGghNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYNRNEVVIATKGAHKFGGDGS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KggkhgpfvkglpfrvdYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEdahgdrwlevfDTAMKGAAVALTKLREEG 169
Cdd:cd19083 93 V----------------LNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDG-----------ETPKAEAVGALQELKDEG 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGVNRVEpcvmALERADPD--VFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG--GKNFEYQE 245
Cdd:cd19083 146 KIRAIGVSNFSLE----QLKEANKDgyVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGkyTKDTKFPD 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 246 AS-----PDKVAAR--------DRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMN 303
Cdd:cd19083 222 NDlrndkPLFKGERfsenldkvDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALD 292
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-302 |
1.19e-39 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 140.03 E-value: 1.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGnmfeevpdDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVgrllraDASKGG 92
Cdd:cd19105 16 LGFGGGGLP--------RESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGLRRDKVFLATKA------SPRLDK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 KhgpfvkglpfrvdydyTADGVRRSIEDSLQRLGMARIDIAYIHDC---AEDAHGDRWLEVFDtamkgaavaltKLREEG 169
Cdd:cd19105 82 K----------------DKAELLKSVEESLKRLQTDYIDIYQLHGVdtpEERLLNEELLEALE-----------KLKKEG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGV-NRVEPCVMALERADP-DVFLLAgrYSLLNQPA-LDELFPRCQERGVhvvvggpynsGIIA-----GGKNF 241
Cdd:cd19105 135 KVRFIGFSThDNMAEVLQAAIESGWfDVIMVA--YNFLNQPAeLEEALAAAAEKGI----------GVVAmktlaGGYLQ 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 242 eyqeaspdkvaarDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLM 302
Cdd:cd19105 203 -------------PALLSVLKAKGFSLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-315 |
2.20e-38 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 138.55 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPrDEFVLSTKVGrlLRADaskgg 92
Cdd:cd19104 15 LTFGGGGIGGLMGRTTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGLP-AGPYITTKVR--LDPD----- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 khgpfvkglpfrvDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEVFDT----AMKGAAVALTKLREE 168
Cdd:cd19104 87 -------------DLGDIGGQIERSVEKSLKRLKRDSVDLLQLHNRIGDERDKPVGGTLSTtdvlGLGGVADAFERLRSE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 169 GVIRAWGL-GVNRVEPCVMALERADPDVFLLAgrYSLLNQPA------------LDELFPRCQERGVHVVVGGPYNSGII 235
Cdd:cd19104 154 GKIRFIGItGLGNPPAIRELLDSGKFDAVQVY--YNLLNPSAaearprgwsaqdYGGIIDAAAEHGVGVMGIRVLAAGAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 236 AG-------GKNFEYQEASPDkVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNA-PIP 307
Cdd:cd19104 232 TTsldrgreAPPTSDSDVAID-FRRAAAFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNREELEEAVAAEAAgPLP 310
|
....*...
gi 2023934258 308 AAFWQELK 315
Cdd:cd19104 311 AENLARLE 318
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
12-300 |
1.88e-37 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 133.41 E-value: 1.88e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGnmfEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYP-RDEFVLSTKVGrllradask 90
Cdd:cd06660 2 RLGLGTMTFG---GDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGnRDDVVIATKGG--------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkHGPfvkgLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaEDAHGDRWLEVFDtamkgaavALTKLREEGV 170
Cdd:cd06660 70 ---HPP----GGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLH---RDDPSTPVEETLE--------ALNELVREGK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLGVNRVEPCVMALERAD----PDVFLLAGRYSLLNQPALD-ELFPRCQERGVHVVVGGPYNSGIIaggknfeyqe 245
Cdd:cd06660 132 IRYIGVSNWSAERLAEALAYAKahglPGFAAVQPQYSLLDRSPMEeELLDWAEENGLPLLAYSPLARGPA---------- 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 246 aspdkvaardrlaeianrhgvdlrAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd06660 202 ------------------------QLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
13-300 |
1.77e-35 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 130.40 E-value: 1.77e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPlgNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVgrllradaSKGG 92
Cdd:cd19074 7 LSLGTWL--TFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWPRESYVISTKV--------FWPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 KHGPFVKGLpfrvdydyTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdRWLEvfDTAMKGAAVALTKLREEGVIR 172
Cdd:cd19074 77 GPGPNDRGL--------SRKHIFESIHASLKRLQLDYVDIYYCH---------RYDP--ETPLEETVRAMDDLIRQGKIL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 173 AWglGVNRVEPCVM--ALERADPdvFLLAG------RYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG------- 237
Cdd:cd19074 138 YW--GTSEWSAEQIaeAHDLARQ--FGLIPpvveqpQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGkyrdgip 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 238 -----------GKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19074 214 ppsrsratdedNRDKKRRLLTDENLEKVKKLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVK 287
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-300 |
2.71e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 127.43 E-value: 2.71e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGnmFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNY------PRDEFVLSTKVG---- 81
Cdd:cd19099 5 SLGLGTYRGD--SDDETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekggiKRDEVVIVTKAGyipg 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 82 ---RLLRADAS--KGGKHGPFVKGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHdCAEDAHGDRWLEVFDTAMK 156
Cdd:cd19099 83 dgdEPLRPLKYleEKLGRGLIDVADSAGLRHCISPAYLEDQIERSLKRLGLDTIDLYLLH-NPEEQLLELGEEEFYDRLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 157 GAAVALTKLREEGVIRAWGLGVN---RVEPC---VMALERADPDVFLLAGR----------YSLLNQPALDE-------- 212
Cdd:cd19099 162 EAFEALEEAVAEGKIRYYGISTWdgfRAPPAlpgHLSLEKLVAAAEEVGGDnhhfkviqlpLNLLEPEALTEkntvkgea 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 213 --LFPRCQERGVHVVVGGPYNSGIIAGGKnfeyqeaspdkvaarDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTK 290
Cdd:cd19099 242 lsLLEAAKELGLGVIASRPLNQGQLLGEL---------------RLADLLALPGGATLAQRALQFARSTPGVDSALVGMR 306
|
330
....*....|
gi 2023934258 291 NPPRVQENVR 300
Cdd:cd19099 307 RPEHVDENLA 316
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
12-305 |
1.79e-33 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 124.96 E-value: 1.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMF-EEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRN--YPRDEFVLSTKVGRllrada 88
Cdd:cd19153 14 PVGLGTAALGGVYgDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAAlqVPRSSYTVATKVGR------ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 89 skgGKHGPFvkglpfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHDCaedAHGDRwlevfDTAMKGAAVALTKLREE 168
Cdd:cd19153 88 ---YRDSEF----------DYSAERVRASVATSLERLHTTYLDVVYLHDI---EFVDY-----DTLVDEALPALRTLKDE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 169 GVIRAWGLGVNRVEPCVMALERADP---DVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQE 245
Cdd:cd19153 147 GVIKRIGIAGYPLDTLTRATRRCSPgslDAVLSYCHLTLQDARLESDAPGLVRGAGPHVINASPLSMGLLTSQGPPPWHP 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 246 ASPDKVAARDRLAEIANRHGVDLRAAALQFC-AAHPVVASVIPGTKNPPRVQENVRLMNAP 305
Cdd:cd19153 227 ASGELRHYAAAADAVCASVEASLPDLALQYSlAAHAGVGTVLLGPSSLAQLRSMLAAVDAV 287
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
12-300 |
1.22e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 123.15 E-value: 1.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGG-APLGNMFE-EVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGrlLRADAS 89
Cdd:cd19149 13 VIGLGTwAIGGGPWWgGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR-RDKVVLATKCG--LRWDRE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKhgpFVKGLPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVfDTAMKGAAVALTKLREEG 169
Cdd:cd19149 90 GGSF---FFVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTH----------WQDV-ETPIEETMEALEELKRQG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLGVNRVEPCVMALERADPDVflLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG----GKNFEYQE 245
Cdd:cd19149 156 KIRAIGASNVSVEQIKEYVKAGQLDI--IQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGkitpDREFDAGD 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 246 A-------SPDKVAARDRLAE----IANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19149 234 ArsgipwfSPENREKVLALLEkwkpLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAK 299
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
13-308 |
2.31e-32 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 123.39 E-value: 2.31e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGaplgnM-FEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRnYPRDEFVLSTKVgrllradaskg 91
Cdd:COG1453 16 LGFGG-----MrLPRKDEEEAEALIRRAIDNGINYIDTARGYGD--SEEFLGKALK-GPRDKVILATKL----------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhGPFVKglpfrvdydyTADGVRRSIEDSLQRLGMARIDIAYIhdcaedaHGDRWLEVFDTAMK--GAAVALTKLREEG 169
Cdd:COG1453 77 ---PPWVR----------DPEDMRKDLEESLKRLQTDYIDLYLI-------HGLNTEEDLEKVLKpgGALEALEKAKAEG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAwgLGV---NRVEPCVMALERADPDVFLLagRYSLLNQ--PALDELFPRCQERGVHVVVGGPynsgiIAGGKNFEyq 244
Cdd:COG1453 137 KIRH--IGFsthGSLEVIKEAIDTGDFDFVQL--QYNYLDQdnQAGEEALEAAAEKGIGVIIMKP-----LKGGRLAN-- 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 245 eaSPDKVAARDRlaeiANRHGVDLraaALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPA 308
Cdd:COG1453 206 --PPEKLVELLC----PPLSPAEW---ALRFLLSHPEVTTVLSGMSTPEQLDENLKTADNLEPL 260
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-307 |
2.62e-32 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 121.09 E-value: 2.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLG------NMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYgpGISEHRFGHVLRNYprDEFVLSTKVgrllra 86
Cdd:cd19097 3 LALGTAQFGldygiaNKSGKPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLKRL--DKFKIITKL------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 daskggkhgPFVKGLPFRVdydytADGVRRSIEDSLQRLGMARIDIAYIHDCAE-DAHGDRWLEvfdtamkgaavALTKL 165
Cdd:cd19097 73 ---------PPLKEDKKED-----EAAIEASVEASLKRLKVDSLDGLLLHNPDDlLKHGGKLVE-----------ALLEL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 166 REEGVIRAWGLGVNRVEPCVMALERADPDVFLLAgrYSLLNQPALDE-LFPRCQERGVHVVVGGPYNSGIIAgGKNFEYQ 244
Cdd:cd19097 128 KKEGLIRKIGVSVYSPEELEKALESFKIDIIQLP--FNILDQRFLKSgLLAKLKKKGIEIHARSVFLQGLLL-MEPDKLP 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 245 EASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIP 307
Cdd:cd19097 205 AKFAPAKPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKPPL 267
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
12-300 |
6.33e-32 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 120.84 E-value: 6.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAEATLV-AAWDAGIRYFDTAPEYGPgiSEHRFGHVLRN----YPRDEFVLSTKVGRllra 86
Cdd:cd19164 15 PLIFGAATFSYQYTTDPESIPPVDIVrRALELGIRAFDTSPYYGP--SEIILGRALKAlrdeFPRDTYFIITKVGR---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 dasKGGKhgpfvkglpfrvDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDcaedahgdrwLE-VFDTAMKGAAVALTKL 165
Cdd:cd19164 89 ---YGPD------------DFDYSPEWIRASVERSLRRLHTDYLDLVYLHD----------VEfVADEEVLEALKELFKL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 166 REEGVIRAWG-----LGVnRVEPCVMALERA-DP-DVFLLAGRYSLLNQpALDELFPRCQERGV--HVVVGGPYNSGIIA 236
Cdd:cd19164 144 KDEGKIRNVGisgypLPV-LLRLAELARTTAgRPlDAVLSYCHYTLQNT-TLLAYIPKFLAAAGvkVVLNASPLSMGLLR 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 237 GGKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFC--AAHPVVASVIpGTKNPPRVQENVR 300
Cdd:cd19164 222 SQGPPEWHPASPELRAAAAKAAEYCQAKGTDLADVALRYAlrEWGGEGPTVV-GCSNVDELEEAVE 286
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-299 |
2.11e-30 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 116.56 E-value: 2.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFG----GAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYP-RDEFVLSTKVGrllra 86
Cdd:cd19093 4 PLGLGtwqwGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGdRDEVVIATKFA----- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 daskggkhgpfvkGLPFRVdydyTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVFDTAMKGAAVALTKLR 166
Cdd:cd19093 79 -------------PLPWRL----TRRSVVKALKASLERLGLDSIDLYQLH----------WPGPWYSQIEALMDGLADAV 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 167 EEGVIRAWGL---GVNRVEPCVMALERADPDVFLLAGRYSLLNQ-PALDELFPRCQERGVHVV---------VGGPYNSG 233
Cdd:cd19093 132 EEGLVRAVGVsnySADQLRRAHKALKERGVPLASNQVEYSLLYRdPEQNGLLPACDELGITLIaysplaqglLTGKYSPE 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023934258 234 IIAGGK-NFEYQEASPDKVAA-RDRLAEIANRHGVDLRAAALQFCAAHPVVAsvIPGTKNPPRVQENV 299
Cdd:cd19093 212 NPPPGGrRRLFGRKNLEKVQPlLDALEEIAEKYGKTPAQVALNWLIAKGVVP--IPGAKNAEQAEENA 277
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-316 |
1.71e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 111.61 E-value: 1.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAPLG---NMFEEVPDDVAE--ATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGRLLR 85
Cdd:cd19102 2 TTIGLGTWAIGgggWGGGWGPQDDRDsiAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL-RDRPIVATKCGLLWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 86 ADAskggkhgpfvkglpfRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWlEVFDTAMKGAAVALTKL 165
Cdd:cd19102 81 EEG---------------RIRRSLKPASIRAECEASLRRLGVDVIDLYQIH----------W-PDPDEPIEEAWGALAEL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 166 REEGVIRAwgLGVNRVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQE 245
Cdd:cd19102 135 KEEGKVRA--IGVSNFSVDQMKRCQAIHPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTPERVA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 246 ASPDK-----------------VAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPA 308
Cdd:cd19102 213 SLPADdwrrrspffqepnlarnLALVDALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTP 292
|
....*...
gi 2023934258 309 AFWQELKQ 316
Cdd:cd19102 293 EELAEIEA 300
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
12-300 |
2.82e-27 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 108.03 E-value: 2.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEevPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYP--RDEFVLSTKVGrLLRADAS 89
Cdd:cd19092 8 RLVLGCMRLADWGE--SAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPglREKIEIQTKCG-IRLGDDP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKHGpfvkglpfrvDYDYTADGVRRSIEDSLQRLGMARIDIAYIH--DCAEDAHgdrwlEVfdtamkgaAVALTKLRE 167
Cdd:cd19092 85 RPGRIK----------HYDTSKEHILASVEGSLKRLGTDYLDLLLLHrpDPLMDPE-----EV--------AEAFDELVK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 168 EGVIRAwgLGVNRVEPCVMALERADPDVFLLAG--RYSLLNQPAL-DELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQ 244
Cdd:cd19092 142 SGKVRY--FGVSNFTPSQIELLQSYLDQPLVTNqiELSLLHTEAIdDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQ 219
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 245 EAspdkvaaRDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19092 220 RL-------RAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVK 268
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
21-299 |
4.82e-26 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 104.23 E-value: 4.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 21 GNMFEEVPDDVAE-ATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVgrllradaskggkhgpfvk 99
Cdd:cd19072 16 GGMSKDYSDDKKAiEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFDREDLFITTKV------------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 100 gLPFRVDYdytaDGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWlEVFDTAMKGAAVALTKLREEGVIRAWGLG-- 177
Cdd:cd19072 77 -SPDHLKY----DDVIKAAKESLKRLGTDYIDLYLIH----------W-PNPSIPIEETLRAMEELVEEGKIRYIGVSnf 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 178 -VNRVEPCVMALERADPDVFLLagRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEyqeaspdkvaardR 256
Cdd:cd19072 141 sLEELEEAQSYLKKGPIVANQV--EYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKGSP-------------L 205
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2023934258 257 LAEIANRHGVDLRAAALQFCAAHPVVAsVIPGTKNPPRVQENV 299
Cdd:cd19072 206 LDEIAKKYGKTPAQIALNWLISKPNVI-AIPKASNIEHLEENA 247
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
13-303 |
9.06e-26 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 103.41 E-value: 9.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGG--APLGNMfEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGrllradask 90
Cdd:cd19096 3 LGFGTmrLPESDD-DSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGPREKFYLATKLP--------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglPFRVDydyTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWL---EVFDTAMKGAAV-ALTKLR 166
Cdd:cd19096 73 -----------PWSVK---SAEDFRRILEESLKRLGVDYIDFYLLH----------GLnspEWLEKARKGGLLeFLEKAK 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 167 EEGVIRAWGLGVN-RVEPCVMALERADPDVFLLAgrYSLLNQPALD--ELFPRCQERGVHVVVGGPYNSGIIAggknfey 243
Cdd:cd19096 129 KEGLIRHIGFSFHdSPELLKEILDSYDFDFVQLQ--YNYLDQENQAgrPGIEYAAKKGMGVIIMEPLKGGGLA------- 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 244 qEASPDKVAARDRlaeiANRHGVDlraAALQFCAAHPVVASVIPGTKNPPRVQENVRLMN 303
Cdd:cd19096 200 -NNPPEALAILCG----APLSPAE---WALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
39-300 |
2.45e-25 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 103.43 E-value: 2.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 39 AWDAGIRYFDTAPEYGPGISEHRFGHVLRNY-PRDEFVLSTKVGRLLRADASKGG---KHgpfvkglpfrvdydytadgV 114
Cdd:cd19079 44 ALDLGINFFDTANVYSGGASEEILGRALKEFaPRDEVVIATKVYFPMGDGPNGRGlsrKH-------------------I 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 115 RRSIEDSLQRLGMARIDIAYIHdcaedahgdRWLEvfDTAMKGAAVALTKLREEGVIR--------AWGLG-VNRvepcV 185
Cdd:cd19079 105 MAEVDASLKRLGTDYIDLYQIH---------RWDY--ETPIEETLEALHDVVKSGKVRyigassmyAWQFAkALH----L 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 186 MALERADPDVfLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG---------------GKNFEYQEASPDK 250
Cdd:cd19079 170 AEKNGWTKFV-SMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARpwgdtterrrsttdtAKLKYDYFTEADK 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2023934258 251 vAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19079 249 -EIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVA 297
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
34-315 |
3.16e-25 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 102.70 E-value: 3.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 34 ATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGrllrADASKGGKHGPFVkglpfrvdyDYTADG 113
Cdd:cd19078 29 ELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF-RDQVVIATKFG----FKIDGGKPGPLGL---------DSRPEH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 114 VRRSIEDSLQRLGMARIDIAYIHdcaedahgdRwlevFDTAMKGAAVALT--KLREEGVIRAWGLGvnrvEPCVMALERA 191
Cdd:cd19078 95 IRKAVEGSLKRLQTDYIDLYYQH---------R----VDPNVPIEEVAGTmkELIKEGKIRHWGLS----EAGVETIRRA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 192 D---PdVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG--GKNFEYQEA---------SPDKVAAR--- 254
Cdd:cd19078 158 HavcP-VTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGkiDENTKFDEGddraslprfTPEALEANqal 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 255 -DRLAEIANRHGVDLRAAALQFC-AAHPVVASvIPGTKNPPRVQENVRLMNAPIPAAFWQELK 315
Cdd:cd19078 237 vDLLKEFAEEKGATPAQIALAWLlAKKPWIVP-IPGTTKLSRLEENIGAADIELTPEELREIE 298
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
20-314 |
9.78e-25 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 101.50 E-value: 9.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 20 LGNM-F-EEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGrllrADASKGgkhgPF 97
Cdd:cd19087 18 LGTMnFgGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGR-RDDIVLATKVF----GPMGDD----PN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 98 VKGLPFRvdydytadGVRRSIEDSLQRLGMARIDIAYIHdcaedaHGDRwlevfDTAMKGAAVALTKLREEGVIR----- 172
Cdd:cd19087 89 DRGLSRR--------HIRRAVEASLRRLQTDYIDLYQMH------HFDR-----DTPLEETLRALDDLVRQGKIRyigvs 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 173 ---AWGLgvnrVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVV---------GGPYN------SGI 234
Cdd:cd19087 150 nfaAWQI----AKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPysplaggllTGKYGkgkrpeSGR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 235 IAGGKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19087 226 LVERARYQARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPELLAEI 305
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
11-299 |
3.05e-24 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 99.21 E-value: 3.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAPL---GNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDeFVLSTKVGrLLRad 87
Cdd:cd19088 2 SRLGYGAMRLtgpGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYPDD-VVIATKGG-LVR-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 88 aSKGGKHGPfvkglpfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHdcAEDAHGDrwlevFDTAMKgaavALTKLRE 167
Cdd:cd19088 78 -TGPGWWGP-----------DGSPEYLRQAVEASLRRLGLDRIDLYQLH--RIDPKVP-----FEEQLG----ALAELQD 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 168 EGVIRAWGLGvnrvEPCVMALERADPDVFLLA--GRYSLLNQPAlDELFPRCQERGVHVVVGGPYNSGiiaggknfeyqe 245
Cdd:cd19088 135 EGLIRHIGLS----NVTVAQIEEARAIVRIVSvqNRYNLANRDD-EGVLDYCEAAGIAFIPWFPLGGG------------ 197
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 246 aspDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENV 299
Cdd:cd19088 198 ---DLAQPGGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENL 248
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
11-299 |
6.13e-24 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 99.21 E-value: 6.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNyPRDEFVLSTKVGRLLRADASK 90
Cdd:cd19076 13 SALGLGCMGMSAFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKD-RRDEVVIATKFGIVRDPGSGF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 GGKHGpfvkglpfRVDYdytadgVRRSIEDSLQRLGMARIDIAYIHDCaedahgDRWLEVFDTAMkgaavALTKLREEGV 170
Cdd:cd19076 92 RGVDG--------RPEY------VRAACEASLKRLGTDVIDLYYQHRV------DPNVPIEETVG-----AMAELVEEGK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLG---------VNRVEPcVMALERadpdvfllagRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAG---- 237
Cdd:cd19076 147 VRYIGLSeasadtirrAHAVHP-ITAVQS----------EYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGaiks 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 238 ----------GKNFEYQEASPDK-VAARDRLAEIANRHGVDLRAAALQFCAA--HPVVAsvIPGTKNPPRVQENV 299
Cdd:cd19076 216 pedlpeddfrRNNPRFQGENFDKnLKLVEKLEAIAAEKGCTPAQLALAWVLAqgDDIVP--IPGTKRIKYLEENV 288
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
32-307 |
6.04e-23 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 96.87 E-value: 6.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 32 AEATLVAAWDAGIRYFDTA--------PEYGpGISEHRFGHVL-RNYPRDEFVLSTKV-GRLLRADASKGGKHGpfvkgl 101
Cdd:cd19094 20 AHEQLDYAFDEGVNFIDTAemypvppsPETQ-GRTEEIIGSWLkKKGNRDKVVLATKVaGPGEGITWPRGGGTR------ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 102 pfrvdydYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEVFDTAMKGAAV-------ALTKLREEGVIRAW 174
Cdd:cd19094 93 -------LDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPLFGGGYYTEPSEEEDSVsfeeqleALGELVKAGKIRHI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 175 GL------GVNRVepCVMALERADPDVFLLAGRYSLLNQ---PALDELfprCQERGVHVVVGGPYNSGIIAG-------- 237
Cdd:cd19094 166 GLsnetpwGVMKF--LELAEQLGLPRIVSIQNPYSLLNRnfeEGLAEA---CHRENVGLLAYSPLAGGVLTGkyldgaar 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023934258 238 --------GKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIP 307
Cdd:cd19094 241 peggrlnlFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDAFDVPLS 318
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
30-305 |
2.94e-22 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 94.63 E-value: 2.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 30 DVAEATLVAAWDAGIRYFDTAPEYG--PGISEHRFGHVLRN---YPRDEFVLSTKVGrllradaskggkHGPFvkGLPFr 104
Cdd:cd19089 29 EEARELLRTAFDLGITHFDLANNYGppPGSAEENFGRILKRdlrPYRDELVISTKAG------------YGMW--PGPY- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 105 vdydytADG-----VRRSIEDSLQRLGMARIDIAYIH--DCaedahgdrwlevfDTAMKGAAVALTKLREEGviRAWGLG 177
Cdd:cd19089 94 ------GDGgsrkyLLASLDQSLKRMGLDYVDIFYHHryDP-------------DTPLEETMTALADAVRSG--KALYVG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 178 VNRVEPCVMA-----LERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGII---------------AG 237
Cdd:cd19089 153 ISNYPGAKARraialLRELGVPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLtdkylngippdsrraAE 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2023934258 238 GKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAP 305
Cdd:cd19089 233 SKFLTEEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKNL 300
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
27-298 |
3.29e-22 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 93.58 E-value: 3.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 27 VPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradaskggkhgpfvkglpfR 104
Cdd:COG0656 15 LPGEEAAAAVRTALEAGYRHIDTAAMYG---NEEGVGEAIAAsgVPREELFVTTKV-----------------------W 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 105 VDyDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrW------LEVFDtamkgaavALTKLREEGVIRAWGL-- 176
Cdd:COG0656 69 ND-NHGYDDTLAAFEESLERLGLDYLDLYLIH----------WpgpgpyVETWR--------ALEELYEEGLIRAIGVsn 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 177 -GVNRVEPcVMALERADPDVfllagrysllNQ----PAL--DELFPRCQERGVHVVVGGPynsgiIAGGKNFEyqeaspD 249
Cdd:COG0656 130 fDPEHLEE-LLAETGVKPAV----------NQvelhPYLqqRELLAFCREHGIVVEAYSP-----LGRGKLLD------D 187
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2023934258 250 KVaardrLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:COG0656 188 PV-----LAEIAEKHGKTPAQVVLRWHLQRGVV--VIPKSVTPERIREN 229
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
29-297 |
8.71e-22 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 93.53 E-value: 8.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 29 DDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNY-PRDEFVLSTKVGrllrADASKGGKhgpfvkglPFRvdy 107
Cdd:cd19148 24 EKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYgKRDRVVIATKVG----LEWDEGGE--------VVR--- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 108 DYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVfDTAMKGAAVALTKLREEGVIRAwgLGVNRVEPCVMA 187
Cdd:cd19148 89 NSSPARIRKEVEDSLRRLQTDYIDLYQVH----------WPDP-LVPIEETAEALKELLDEGKIRA--IGVSNFSPEQME 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 188 LERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKN----FE----------YQEASPDK-VA 252
Cdd:cd19148 156 TFRKVAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKMTkdtkFEgddlrrtdpkFQEPRFSQyLA 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2023934258 253 ARDRLAEIAN-RHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQE 297
Cdd:cd19148 236 AVEELDKLAQeRYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDA 281
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
13-298 |
1.47e-21 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 91.77 E-value: 1.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGnmfeevPDDVAEATLvAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNY--PRDEFVLSTKVGrllradask 90
Cdd:cd19071 4 IGLGTYKLK------PEETAEAVL-AALEAGYRHIDTAAAYG---NEAEVGEAIRESgvPREELFITTKLW--------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglpfrvDYDYTADGVRRSIEDSLQRLGMARIDIAYIH---DCAEDAHGDRWLEVFDtamkgaavALTKLRE 167
Cdd:cd19071 65 ---------------PTDHGYERVREALEESLKDLGLDYLDLYLIHwpvPGKEGGSKEARLETWR--------ALEELVD 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 168 EGVIRAwgLGV-N-------------RVEPCVMALEradpdvfllagrYSLLNQPalDELFPRCQERGVHVVVGGPYNSG 233
Cdd:cd19071 122 EGLVRS--IGVsNfnvehleellaaaRIKPAVNQIE------------LHPYLQQ--KELVEFCKEHGIVVQAYSPLGRG 185
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 234 iiaggknfeyqeasPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19071 186 --------------RRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVV--VIPKSSNPERIKEN 234
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
25-299 |
4.66e-20 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 88.81 E-value: 4.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 25 EEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLR--NYPRDEFVLSTKV--GrllradaskGGKHGPFVKG 100
Cdd:cd19143 26 NQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKelGWPRSDYVVSTKIfwG---------GGGPPPNDRG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 101 LPFRvdydYTADGVRRsiedSLQRLGMARIDIAYIHdcaedaHGDRwlevfDTAMKGAAVALTKLREEGVIRAWGLGVNR 180
Cdd:cd19143 97 LSRK----HIVEGTKA----SLKRLQLDYVDLVFCH------RPDP-----ATPIEETVRAMNDLIDQGKAFYWGTSEWS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 181 VEPCVMALERADpdvfllagRYSL----LNQPALD---------ELFPRCQERGVHV---------VVGGPYNSGIIAGG 238
Cdd:cd19143 158 AQQIEEAHEIAD--------RLGLippvMEQPQYNlfhrervevEYAPLYEKYGLGTttwsplasgLLTGKYNNGIPEGS 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 239 ---------KNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENV 299
Cdd:cd19143 230 rlalpgyewLKDRKEELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENL 299
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
11-300 |
3.89e-19 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 86.13 E-value: 3.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAplGNMFEEVPD-DVAEAT-LV-AAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGrllrad 87
Cdd:cd19091 19 GTMTFGGG--GGFFGAWGGvDQEEADrLVdIALDAGINFFDTADVYSEGESEEILGKALKGR-RDDVLIATKVR------ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 88 askggkhgpfvkglpFRVDYDYTADGVRR-----SIEDSLQRLGMARIDIAYIHdcAEDAHG--DRWLEVFDTamkgaAV 160
Cdd:cd19091 90 ---------------GRMGEGPNDVGLSRhhiirAVEASLKRLGTDYIDLYQLH--GFDALTplEETLRALDD-----LV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 161 ALTKLREEGV--IRAW----GLGVNRVEpcvmALERadpdVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGI 234
Cdd:cd19091 148 RQGKVRYIGVsnFSAWqimkALGISERR----GLAR----FVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 235 IAG-------------GKNFEYQEASPDKVAAR---DRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQEN 298
Cdd:cd19091 220 LSGkyrrgqpapegsrLRRTGFDFPPVDRERGYdvvDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDN 299
|
..
gi 2023934258 299 VR 300
Cdd:cd19091 300 LG 301
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
14-300 |
7.99e-18 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 82.48 E-value: 7.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 14 GFGGAPlgnmfeeVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVGrllradASKGGK 93
Cdd:cd19145 24 GDYGAP-------KPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGPREKVQLATKFG------IHEIGG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 94 HGPFVKGLPfrvDYdytadgVRRSIEDSLQRLGMARIDIAYIHDCaedahgDRWLEVFDTAMkgaavALTKLREEGVIRA 173
Cdd:cd19145 91 SGVEVRGDP---AY------VRAACEASLKRLDVDYIDLYYQHRI------DTTVPIEITMG-----ELKKLVEEGKIKY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 174 WGLGvnrvEPCVMALERA---DPdVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFE-------- 242
Cdd:cd19145 151 IGLS----EASADTIRRAhavHP-ITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEellensdv 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 243 ------YQEASPDK-VAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19145 226 rkshprFQGENLEKnKVLYERVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIG 290
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-302 |
1.30e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 81.87 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 30 DVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRNYPRDEFVLSTKVGrllradaskggkhgpFVKGLPFRVDYDY 109
Cdd:cd19101 23 DAAVRAMAAYVDAGLTTFDCADIYGP--AEELIGEFRKRLRRERDAADDVQI---------------HTKWVPDPGELTM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 110 TADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVFDTAMKGAAVALTKLREEGVIRAWGL---GVNRVEPCVm 186
Cdd:cd19101 86 TRAYVEAAIDRSLKRLGVDRLDLVQFH----------WWDYSDPGYLDAAKHLAELQEEGKIRHLGLtnfDTERLREIL- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 187 aleRADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVvggPYnsGIIAGGKNFE--YQEASPDKVAARDR-------- 256
Cdd:cd19101 155 ---DAGVPIVSNQVQYSLLDRRPENGMAALCEDHGIKLL---AY--GTLAGGLLSEkyLGVPEPTGPALETRslqkyklm 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2023934258 257 ----------------LAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLM 302
Cdd:cd19101 227 idewggwdlfqellrtLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAF 288
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
12-314 |
3.56e-17 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 80.34 E-value: 3.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGaplgNMFEEVPDDVAEATLVAAW-DAGIRYFDTAPEYGP-------GISEHRFGHVL-RNYPRDEFVLSTKVGR 82
Cdd:cd19081 11 PLCLGT----MVFGWTADEETSFALLDAFvDAGGNFIDTADVYSAwvpgnagGESETIIGRWLkSRGKRDRVVIATKVGF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 83 LLRADAskggkhgpfvKGLpfrvdydyTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEvfdtamkgaavAL 162
Cdd:cd19081 87 PMGPNG----------PGL--------SRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLG-----------AL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 163 TKLREEGVIRAWGLGVNRVEPCVMALERAD----PDVFLLAGRYSLLNQPALD-ELFPRCQERGVHVVVGGPYNSGIIAG 237
Cdd:cd19081 138 NDLIRQGKVRYIGASNYSAWRLQEALELSRqhglPRYVSLQPEYNLVDRESFEgELLPLCREEGIGVIPYSPLAGGFLTG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 238 gknfEYQ-EASPDKVAAR----------------DRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19081 218 ----KYRsEADLPGSTRRgeaakrylnerglrilDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLA 293
|
330
....*....|....
gi 2023934258 301 LMNAPIPAAFWQEL 314
Cdd:cd19081 294 AAGLRLTDEEVARL 307
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
13-298 |
2.00e-16 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 77.31 E-value: 2.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradask 90
Cdd:cd19073 4 LGLG------TWQLRGDDCANA-VKEALELGYRHIDTAEIYN---NEAEVGEAIAEsgVPREDLFITTKV---------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglpFRVDYDYtaDGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEvfdtamkgaavALTKLREEGV 170
Cdd:cd19073 64 ------------WRDHLRP--EDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLG-----------ALKELKEAGK 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRawGLGVNRVEPCVM--ALERADPDVFLLAGRYS-LLNQPALDELfprCQERGVHVVVGGPynsgiIAGGKNFEYqeas 247
Cdd:cd19073 119 VK--SIGVSNFTIELLeeALDISPLPIAVNQVEFHpFLYQAELLEY---CRENDIVITAYSP-----LARGEVLRD---- 184
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 248 pdkvaarDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19073 185 -------PVIQEIAEKYDKTPAQVALRWLVQKGIV--VIPKASSEDHLKEN 226
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
4-299 |
4.67e-16 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 77.48 E-value: 4.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 4 TQHFAPPGP----LGFGGAPLGNMFEEV-PDDVAEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVLRNYP--RDEFVL 76
Cdd:cd19144 3 TRTLGRNGPsvpaLGFGAMGLSAFYGPPkPDEERFAVLDAAFELGCTFWDTADIYGD--SEELIGRWFKQNPgkREKIFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 77 STKVGrlLRADASKGGkhgPFVKGLPfrvdyDYtadgVRRSIEDSLQRLGMARIDIAYIHDcaedahgdrwlevFD--TA 154
Cdd:cd19144 81 ATKFG--IEKNVETGE---YSVDGSP-----EY----VKKACETSLKRLGVDYIDLYYQHR-------------VDgkTP 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 155 MKGAAVALTKLREEGVIRAWGLGvnrvEPCVMALERA---DP--DVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGP 229
Cdd:cd19144 134 IEKTVAAMAELVQEGKIKHIGLS----ECSAETLRRAhavHPiaAVQIEYSPFSLDIERPEIGVLDTCRELGVAIVAYSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 230 YNSGIIAGG----KNFE----------YQ-EASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPR 294
Cdd:cd19144 210 LGRGFLTGAirspDDFEegdfrrmaprFQaENFPKNLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKR 289
|
....*
gi 2023934258 295 VQENV 299
Cdd:cd19144 290 LEENL 294
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
11-298 |
5.92e-16 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 76.89 E-value: 5.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPG---ISEHRFGHVLRNYP--RDEFVLSTKVGrllr 85
Cdd:cd19077 6 GPIGLGLMGLTWRPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPdphANLKLLARFFRKYPeyADKVVLSVKGG---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 86 adaskggkhgpfVKGLPFRVDYDYtaDGVRRSIEDSLQRLGM-ARIDiayIHDCAedahgdrwleVFDTAMKGAAV--AL 162
Cdd:cd19077 82 ------------LDPDTLRPDGSP--EAVRKSIENILRALGGtKKID---IFEPA----------RVDPNVPIEETikAL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 163 TKLREEGVIRAWGLGvnrvEPCVMALERADPDVFLLAGR--YSLLNQPALD-ELFPRCQERGVHVVVGGPYNSGIIAGgk 239
Cdd:cd19077 135 KELVKEGKIRGIGLS----EVSAETIRRAHAVHPIAAVEveYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGLLTG-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 240 nfeyQEASPDKVAARD---------------------RLAEIANRHGVDLRAAALQFCAAHPVVASV-IPGTKNPPRVQE 297
Cdd:cd19077 209 ----RIKSLADIPEGDfrrhldrfngenfeknlklvdALQELAEKKGCTPAQLALAWILAQSGPKIIpIPGSTTLERVEE 284
|
.
gi 2023934258 298 N 298
Cdd:cd19077 285 N 285
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
17-302 |
1.04e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 76.22 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 17 GAPLGNMF--EEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKvgrllradaskggkh 94
Cdd:cd19103 17 GGAGGDQVfgNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYPREDYIISTK--------------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 95 gpFVKGLPfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAeDAhgDRWLEvfdtamkgaavALTKLREEGVIRAW 174
Cdd:cd19103 82 --FTPQIA-----GQSADPVADMLEGSLARLGTDYIDIYWIHNPA-DV--ERWTP-----------ELIPLLKSGKVKHV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 175 GLGVNRVEPCVMA---LERADPDVFLLAGRYSLLNQ-PALDELFPRCQERGV----HVV-----VGGPYNSG--IIAG-G 238
Cdd:cd19103 141 GVSNHNLAEIKRAneiLAKAGVSLSAVQNHYSLLYRsSEEAGILDYCKENGItffaYMVleqgaLSGKYDTKhpLPEGsG 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 239 KNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVAsvIPGTKNPPRVQENVRLM 302
Cdd:cd19103 221 RAETYNPLLPQLEELTAVMAEIGAKHGASIAQVAIAWAIAKGTTP--IIGVTKPHHVEDAARAA 282
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
28-303 |
2.95e-15 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 75.41 E-value: 2.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 28 PDDVAEATLVAAWDAGIRYFDTAPEYGP--GISEHRFGHVLRN----YpRDEFVLSTKVGRLLRAdaskggkhGPFVKGl 101
Cdd:PRK09912 41 ALESQRAILRKAFDLGITHFDLANNYGPppGSAEENFGRLLREdfaaY-RDELIISTKAGYDMWP--------GPYGSG- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 102 pfrvdydytadGVRR----SIEDSLQRLGMARIDIAYIHDCAEdahgdrwlevfDTAMKGAAVALTKLREEGviRAWGLG 177
Cdd:PRK09912 111 -----------GSRKyllaSLDQSLKRMGLEYVDIFYSHRVDE-----------NTPMEETASALAHAVQSG--KALYVG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 178 VN-----RVEPCVMALERADPDVFLLAGRYSLLNQpALDE--LFPRCQERGVHVVVGGPYNSGIIAGgknfEYQEASPD- 249
Cdd:PRK09912 167 ISsyspeRTQKMVELLREWKIPLLIHQPSYNLLNR-WVDKsgLLDTLQNNGVGCIAFTPLAQGLLTG----KYLNGIPQd 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 250 ----KVAARDR-----------------LAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMN 303
Cdd:PRK09912 242 srmhREGNKVRgltpkmlteanlnslrlLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALN 316
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
39-305 |
2.99e-15 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 75.13 E-value: 2.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 39 AWDAGIRYFDTAPEYGP--GISEHRFGHVLRN----YpRDEFVLSTKVGRLLRAdaskggkhGPfvkglpfrvdydYTAD 112
Cdd:cd19151 39 AFDLGITHFDLANNYGPppGSAEENFGRILKEdlkpY-RDELIISTKAGYTMWP--------GP------------YGDW 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 113 GVRR----SIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEVFDTAMK-GAA--VALTKLREEGVIRAWGLGVNRVEPCV 185
Cdd:cd19151 98 GSKKyliaSLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRqGKAlyVGISNYPPEEAREAAAILKDLGTPCL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 186 MalerADPdvfllagRYSLLNQPALDELFPRCQERGVHVVVGGP---------YNSGIIA------GGKNFEYQEASPDK 250
Cdd:cd19151 178 I----HQP-------KYSMFNRWVEEGLLDVLEEEGIGCIAFSPlaqglltdrYLNGIPEdsraakGSSFLKPEQITEEK 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 251 VAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAP 305
Cdd:cd19151 247 LAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALDNR 301
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
12-300 |
3.31e-15 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 74.21 E-value: 3.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEVPDDVAeaTLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVgrlLRADASKg 91
Cdd:cd19138 13 ALGQGTWYMGEDPAKRAQEIE--ALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGR-RDKVFLVSKV---LPSNASR- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 92 gkhgpfvkglpfrvdydytaDGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWL------EVFDtamkgaavALTKL 165
Cdd:cd19138 86 --------------------QGTVRACERSLRRLGTDYLDLYLLH----------WRggvplaETVA--------AMEEL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 166 REEGVIRAWG---LGVNRVEpcvmALERAdPDVFLLAG---RYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGK 239
Cdd:cd19138 128 KKEGKIRAWGvsnFDTDDME----ELWAV-PGGGNCAAnqvLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRRG 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 240 NFEyqeaspdkvaaRDRLAEIANRHGVDLRAAALQFCAAHPVVASvIPGTKNPPRVQENVR 300
Cdd:cd19138 203 LLE-----------NPTLKEIAARHGATPAQVALAWVLRDGNVIA-IPKSGSPEHARENAA 251
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
29-314 |
6.09e-15 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 74.18 E-value: 6.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 29 DDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYpRDEFVLSTKVGRLLRA-DASKGGKHgpfvkglpfrvdy 107
Cdd:cd19080 30 REEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN-RDRIVLATKYTMNRRPgDPNAGGNH------------- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 108 dytADGVRRSIEDSLQRLGMARIDIAYIH--DCAEDAHgdrwlEVFDtamkgaavALTKLREEGVIRAWGLG------VN 179
Cdd:cd19080 96 ---RKNLRRSVEASLRRLQTDYIDLLYVHawDFTTPVE-----EVMR--------ALDDLVRAGKVLYVGISdtpawvVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 180 RVEpcVMALERADPDVFLLAGRYSLLNQPALDELFPRCQERGVHVVVGGPYNSGIIAGGKNFEYQE---------ASPDK 250
Cdd:cd19080 160 RAN--TLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGrageakgvtVGFGK 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 251 VAAR-----DRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:cd19080 238 LTERnwaivDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARL 306
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
12-300 |
7.95e-15 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 73.36 E-value: 7.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMfeeVPDDVAEATLVAAWDAGIRYFDTAPEYG----PGISEHRFGHVLRNYP-RDEFVLSTKvgrllra 86
Cdd:cd19082 2 RIVLGTADFGTR---IDEEEAFALLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKSRGnRDKVVIATK------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 daskGGKHGPFVKGLPfRVDydytADGVRRSIEDSLQRLGMARIDIAYIH-DcaedahgdrwlevfDTAMKGAAV--ALT 163
Cdd:cd19082 72 ----GGHPDLEDMSRS-RLS----PEDIRADLEESLERLGTDYIDLYFLHrD--------------DPSVPVGEIvdTLN 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 164 KLREEGVIRAWGL---GVNRVE-----------PCVMALER----ADPDVFLLAG-----------RYSLLNQPAldeLF 214
Cdd:cd19082 129 ELVRAGKIRAFGAsnwSTERIAeanayakahglPGFAASSPqwslARPNEPPWPGptlvamdeemrAWHEENQLP---VF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 215 P-RCQERGvhvvvggpYNSGIIAGGKNFEYQEA----SPDKVAARDRLAEIANRHGVDLRAAALQF--CAAHPVVASVip 287
Cdd:cd19082 206 AySSQARG--------FFSKRAAGGAEDDSELRrvyySEENFERLERAKELAEEKGVSPTQIALAYvlNQPFPTVPII-- 275
|
330
....*....|...
gi 2023934258 288 GTKNPPRVQENVR 300
Cdd:cd19082 276 GPRTPEQLRDSLA 288
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
29-300 |
3.72e-14 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 71.06 E-value: 3.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 29 DDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPRDEFVLSTKVgrllradaskggkhgpfvkgLPFRVDYd 108
Cdd:cd19137 25 DEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFPREDLFIVTKV--------------------WPTNLRY- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 109 ytaDGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVfDTAMKGAAVALTKLREEGVIRAWGLGVNRVEPCVMAL 188
Cdd:cd19137 84 ---DDLLRSLQNSLRRLDTDYIDLYLIH----------WPNP-NIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 189 ERADPDVFLLAGRYSLLNQ-PALDELFPRCQERGVHVVVGGPYNSGIiaggknfeyqeaspdkVAARDRLAEIANRHGVD 267
Cdd:cd19137 150 SKSQTPIVCNQVKYNLEDRdPERDGLLEYCQKNGITVVAYSPLRRGL----------------EKTNRTLEEIAKNYGKT 213
|
250 260 270
....*....|....*....|....*....|...
gi 2023934258 268 LRAAALQFCAAHPVVASvIPGTKNPPRVQENVR 300
Cdd:cd19137 214 IAQIALAWLIQKPNVVA-IPKAGRVEHLKENLK 245
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
15-279 |
6.45e-14 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 71.05 E-value: 6.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 15 FGGAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLrnYPRDEFVLSTKVgrllradaskggkh 94
Cdd:cd19075 5 LGTMTFGSQGRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELG--LGERGFKIDTKA-------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 95 gpfvkglPFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIHdcAEDAhgdrwlevfDTAMKGAAVALTKLREEGVIRAW 174
Cdd:cd19075 69 -------NPGVGGGLSPENVRKQLETSLKRLKVDKVDVFYLH--APDR---------STPLEETLAAIDELYKEGKFKEF 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 175 GLG------VNRVepcvmaLERAD------PDVFllAGRYSLLNQPALDELFPRCQERGVHVVVggpYNSgiIAGG---K 239
Cdd:cd19075 131 GLSnysaweVAEI------VEICKengwvlPTVY--QGMYNAITRQVETELFPCLRKLGIRFYA---YSP--LAGGfltG 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2023934258 240 NFEYQEASP-------------------DK---VAARDRLAEIANRHGVDLRAAALQFCAAH 279
Cdd:cd19075 198 KYKYSEDKAgggrfdpnnalgklyrdryWKpsyFEALEKVEEAAEKEGISLAEAALRWLYHH 259
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
22-303 |
9.25e-14 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 70.56 E-value: 9.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 22 NMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGP--GISEHRFGHVLRN----YpRDEFVLSTKVGRLLRAdaskggkhG 95
Cdd:cd19150 22 NFGDDTPLETQRAILRTAFDLGITHFDLANNYGPppGSAEENFGRILREdfagY-RDELIISTKAGYDMWP--------G 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 96 PFVKGlpfrvdydytadGVRR----SIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEVFDTAMK-GAA--VALTKLREE 168
Cdd:cd19150 93 PYGEW------------GSRKyllaSLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRsGKAlyVGISSYSPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 169 GVIRAWGLGVNRVEPCVMalerADPDvfllagrYSLLNQ-PALDELFPRCQERGVHVVVGGP---------YNSGIIAG- 237
Cdd:cd19150 161 RTREAAAILRELGTPLLI----HQPS-------YNMLNRwVEESGLLDTLQELGVGCIAFTPlaqglltdkYLNGIPEGs 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 238 ----GKNFEYQEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMN 303
Cdd:cd19150 230 raskERSLSPKMLTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALD 299
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
12-303 |
1.48e-13 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 69.22 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGnmfeevpDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradas 89
Cdd:cd19132 9 AIGFGTYPLK-------GDEGVEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRsgVPREELFVTTKL--------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKHGpfvkglpfrvdydytADGVRRSIEDSLQRLGMARIDIAYIHdcAEDAHGDRWLEVFDtamkgaavALTKLREEG 169
Cdd:cd19132 70 PGRHHG---------------YEEALRTIEESLYRLGLDYVDLYLIH--WPNPSRDLYVEAWQ--------ALIEAREEG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAwgLGV-NRVEPCVMALERAdpdvfllAGRYSLLNQPALDELFPRCQERGVHVvvggpyNSGIIAggknfeyQEASP 248
Cdd:cd19132 125 LVRS--IGVsNFLPEHLDRLIDE-------TGVTPAVNQIELHPYFPQAEQRAYHR------EHGIVT-------QSWSP 182
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 249 ----DKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRLMN 303
Cdd:cd19132 183 lgrgSGLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVV--PIPKSANPERQRENLAIFD 239
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
15-299 |
7.52e-13 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 68.14 E-value: 7.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 15 FGGaplgnmfeEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLR--NYPRDEFVLSTKVGRLLRADASKGG 92
Cdd:cd19159 24 FGG--------QISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKkkGWRRSSLVITTKLYWGGKAETERGL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 93 KHGPFVKGLpfrvdydytadgvrrsiEDSLQRLGMARIDIAYIHdcAEDAhgdrwlevfDTAMKGAAVALTKLREEGVIR 172
Cdd:cd19159 96 SRKHIIEGL-----------------KGSLQRLQLEYVDVVFAN--RPDS---------NTPMEEIVRAMTHVINQGMAM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 173 AWGLGVNRVEPCVMALERAD-----PDVFLLAgRYSLLNQPALDELFPRCQER-GVHVVVGGPYNSGIIAGgknfEYQEA 246
Cdd:cd19159 148 YWGTSRWSAMEIMEAYSVARqfnmiPPVCEQA-EYHLFQREKVEVQLPELYHKiGVGAMTWSPLACGIISG----KYGNG 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2023934258 247 SPDKVAA--------RDR---------------LAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENV 299
Cdd:cd19159 223 VPESSRAslkcyqwlKERivseegrkqqnklkdLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENL 298
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
26-298 |
6.71e-12 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 64.70 E-value: 6.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 26 EVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKvgrlLRADASkggkhgpfvkglpf 103
Cdd:cd19131 19 QVSNDEAASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRAsgVPREELFITTK----LWNSDQ-------------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 104 rvDYDYTadgvRRSIEDSLQRLGMARIDIAYIH--DCAEDAHGDRWlevfdtamkgaaVALTKLREEGVIRAwgLGVNRV 181
Cdd:cd19131 78 --GYDST----LRAFDESLRKLGLDYVDLYLIHwpVPAQDKYVETW------------KALIELKKEGRVKS--IGVSNF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 182 EPcvMALERadpdVFLLAGRYSLLNQPaldELFPRCQERGVHVvvggpynsgiIAGGKNFEYQEASP---DKVAARDRLA 258
Cdd:cd19131 138 TI--EHLQR----LIDETGVVPVVNQI---ELHPRFQQRELRA----------FHAKHGIQTESWSPlgqGGLLSDPVIG 198
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2023934258 259 EIANRHGvdlRAAALQFCAAHpvVAS---VIPGTKNPPRVQEN 298
Cdd:cd19131 199 EIAEKHG---KTPAQVVIRWH--LQNglvVIPKSVTPSRIAEN 236
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
41-300 |
5.50e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 62.35 E-value: 5.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 41 DAGIRYFDTAPEYG-------PGISEHRFGHVLRNYP-RDEFVLSTKVGrllradASKGGKHGPFvkglpfRVDYDYTAD 112
Cdd:cd19752 28 AAGGNFLDTANNYAfwteggvGGESERLIGRWLKDRGnRDDVVIATKVG------AGPRDPDGGP------ESPEGLSAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 113 GVRRSIEDSLQRLGMARIDIAYIHdcAEDahgdrwlevFDTAMKGAAVALTKLREEGVIRAWGLGVNRVEpcvmALERAD 192
Cdd:cd19752 96 TIEQEIDKSLRRLGTDYIDLYYAH--VDD---------RDTPLEETLEAFNELVKAGKVRAIGASNFAAW----RLERAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 193 --------PDVFLLAGRYSLL----------NQPALDELFPRCQERGVHVVVggPYnSGIIAG-----GKNFEYQEASPD 249
Cdd:cd19752 161 qiarqqgwAEFSAIQQRHSYLrprpgadfgvQRIVTDELLDYASSRPDLTLL--AY-SPLLSGaytrpDRPLPEQYDGPD 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 250 KVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVR 300
Cdd:cd19752 238 SDARLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLA 288
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
12-301 |
8.64e-11 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 61.91 E-value: 8.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGgaplgnMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNY------PRDEFVLSTKVGrllr 85
Cdd:cd19116 13 AIALG------TWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREKiaegvvKREDLFITTKLW---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 86 adaskGGKHGPfvkglpfrvdydytaDGVRRSIEDSLQRLGMARID-------IAYIHDCAEDAHGDrwLEVFDTAMKGA 158
Cdd:cd19116 80 -----NSYHER---------------EQVEPALRESLKRLGLDYVDlylihwpVAFKENNDSESNGD--GSLSDIDYLET 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 159 AVALTKLREEGVIRAWGLG------VNRVepcvmaLERAD--PDVfllagrysllNQ----PAL--DELFPRCQERGVHV 224
Cdd:cd19116 138 WRGMEDLVKLGLTRSIGVSnfnseqINRL------LSNCNikPAV----------NQievhPTLtqEKLVAYCQSNGIVV 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2023934258 225 VVGGPYNSGIIAGGKNFEYQEASPdkvaardRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRL 301
Cdd:cd19116 202 MAYSPFGRLVPRGQTNPPPRLDDP-------TLVAIAKKYGKTTAQIVLRYLIDRGVV--PIPKSSNKKRIKENIDI 269
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
13-302 |
1.59e-10 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 60.67 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradask 90
Cdd:cd19133 12 LGFG------VFQIPDPEECERAVLEAIKAGYRLIDTAAAYG---NEEAVGRAIKKsgIPREELFITTKL---------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglpFRVDYDYtaDGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHgdrwlevfdtamkGAAVALTKLREEGV 170
Cdd:cd19133 73 ------------WIQDAGY--EKAKKAFERSLKRLGLDYLDLYLIHQPFGDVY-------------GAWRAMEELYKEGK 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLG------------VNRVEPCVMALEradpdvfllagrYSLLNQPalDELFPRCQERGVHVVVGGPynsgiIAGG 238
Cdd:cd19133 126 IRAIGVSnfypdrlvdlilHNEVKPAVNQIE------------THPFNQQ--IEAVEFLKKYGVQIEAWGP-----FAEG 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 239 KNFEYQEaspdkvaarDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRLM 302
Cdd:cd19133 187 RNNLFEN---------PVLTEIAEKYGKSVAQVILRWLIQRGIV--VIPKSVRPERIAENFDIF 239
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
27-175 |
1.91e-10 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 60.94 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 27 VPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLR--NYPRDEFVLSTKVgrllradaskGGKHGPFVKGLPFR 104
Cdd:cd19142 28 ISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKkkGWKRSSYIVSTKI----------YWSYGSEERGLSRK 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 105 VdydytadgVRRSIEDSLQRLGMARIDIAYIHDCaeDAHgdrwlevfdTAMKGAAVALTKLREEGVIRAWG 175
Cdd:cd19142 98 H--------IIESVRASLRRLQLDYIDIVIIHKA--DPM---------CPMEEVVRAMSYLIDNGLIMYWG 149
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
13-299 |
2.00e-10 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 60.92 E-value: 2.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGG-APLGNmfeEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLR--NYPRDEFVLSTKVGRLLRADAS 89
Cdd:cd19141 15 LGLGTwVTFGS---QISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKkkGWRRSSYVITTKIFWGGKAETE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKHGPFVKGLpfrvdydytadgvrrsiEDSLQRLGMARIDIAYIHdcAEDAHgdrwlevfdTAMKGAAVALTKLREEG 169
Cdd:cd19141 92 RGLSRKHIIEGL-----------------KASLERLQLEYVDIVFAN--RPDPN---------TPMEEIVRAFTHVINQG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 170 VIRAWGLG----------------VNRVEPCVmalERADPDVFllaGRYSLLNQpaLDELFPRCqerGVHVVVGGPYNSG 233
Cdd:cd19141 144 MAMYWGTSrwsameimeaysvarqFNLIPPIV---EQAEYHLF---QREKVEMQ--LPELFHKI---GVGAMTWSPLACG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 234 IIAGG-------------KNFEY------QEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPR 294
Cdd:cd19141 213 ILSGKyddgvpeysraslKGYQWlkekilSEEGRRQQAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQ 292
|
....*
gi 2023934258 295 VQENV 299
Cdd:cd19141 293 LYENL 297
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
26-299 |
2.22e-10 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 60.87 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 26 EVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRN--YPRDEFVLSTKVGRLLRADASKGGKHGPFVKGLpf 103
Cdd:cd19158 27 QITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKkgWRRSSLVITTKIFWGGKAETERGLSRKHIIEGL-- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 104 rvdydytadgvrrsiEDSLQRLGMARIDIAYIHDCAEdahgdrwlevfDTAMKGAAVALTKLREEGVIRAWGL----GVN 179
Cdd:cd19158 105 ---------------KASLERLQLEYVDVVFANRPDP-----------NTPMEETVRAMTHVINQGMAMYWGTsrwsSME 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 180 RVEPCVMALERADPDVFLLAGRYSLLNQPALDELFPRCQER-GVHVVVGGPYNSGIIAGGKNF---EYQEAS-------P 248
Cdd:cd19158 159 IMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKiGVGAMTWSPLACGIVSGKYDSgipPYSRASlkgyqwlK 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 249 DKVAARD---------RLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENV 299
Cdd:cd19158 239 DKILSEEgrrqqaklkELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENI 298
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
4-298 |
2.56e-10 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 59.96 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 4 TQHFAPPGPLGFGGAPLgnmfeeVPDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVG 81
Cdd:cd19140 2 TVNGVRIPALGLGTYPL------TGEECTRA-VEHALELGYRHIDTAQMYG---NEAQVGEAIAAsgVPRDELFLTTKVW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 82 RLlradaskggkhgpfvkglpfrvdyDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrWLEVfDTAMKGAAVA 161
Cdd:cd19140 72 PD------------------------NYSPDDFLASVEESLRKLRTDYVDLLLLH----------WPNK-DVPLAETLGA 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 162 LTKLREEGVIRAwgLGVNRVEPCVM--ALERADPDVFLLAGRYS-LLNQPALDELfprCQERGVHVVVGGPynsgiIAGG 238
Cdd:cd19140 117 LNEAQEAGLARH--IGVSNFTVALLreAVELSEAPLFTNQVEYHpYLDQRKLLDA---AREHGIALTAYSP-----LARG 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 239 KNFEYQEaspdkvaardrLAEIANRHGVDLRAAALQFCAAHPVVAsVIPGTKNPPRVQEN 298
Cdd:cd19140 187 EVLKDPV-----------LQEIGRKHGKTPAQVALRWLLQQEGVA-AIPKATNPERLEEN 234
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
13-298 |
8.10e-10 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 58.60 E-value: 8.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVGrllradask 90
Cdd:cd19126 12 LGLG------VFQTPDGDETERAVQTALENGYRSIDTAAIYK---NEEGVGEAIREsgVPREELFVTTKLW--------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglpfrvDYDYTADGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWlevfdtamkgaaVALTKLREEGV 170
Cdd:cd19126 74 ---------------NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKDKFIDTW------------KALEKLYASGK 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWG------------LGVNRVEPCVMALEradpdvfllagRYSLLNQPALDELfprCQERGVHVVVGGPYNSGIiagg 238
Cdd:cd19126 127 VKAIGvsnfqehhleelLAHADVVPAVNQVE-----------FHPYLTQKELRGY---CKSKGIVVEAWSPLGQGG---- 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 239 knfeyqeaspdkVAARDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19126 189 ------------LLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVV--TIPKSVHASRIKEN 234
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
28-322 |
9.89e-10 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 58.51 E-value: 9.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 28 PDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNYPRDEFVLstkvgrllRAD---ASKggkhgpfvkglpFR 104
Cdd:cd19125 23 PGVVGNA-VKTAIKEGYRHIDCAAIYG---NEKEIGKALKKLFEDGVVK--------REDlfiTSK------------LW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 105 VDYDYTADgVRRSIEDSLQRLGMARIDIAYIH---DCAEDAHGDRWLEVFDTAMKGAAVALTKLREEGVIRAWG------ 175
Cdd:cd19125 79 CTDHAPED-VPPALEKTLKDLQLDYLDLYLIHwpvRLKKGAHMPEPEEVLPPDIPSTWKAMEKLVDSGKVRAIGvsnfsv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 176 ------LGVNRVEPCVMALERadpdvfllagrYSLLNQpalDELFPRCQERGVHVVVGGPY-NSGIIAGGKNfeyqeasp 248
Cdd:cd19125 158 kkledlLAVARVPPAVNQVEC-----------HPGWQQ---DKLHEFCKSKGIHLSAYSPLgSPGTTWVKKN-------- 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 249 dkVAARDRLAEIANRHG-----VDLRAAALQFCaahpvvaSVIPGTKNPPRVQENVRLMNAPIPAAFWQELkqSGILPQ 322
Cdd:cd19125 216 --VLKDPIVTKVAEKLGktpaqVALRWGLQRGT-------SVLPKSTNEERIKENIDVFDWSIPEEDFAKF--SSIEQQ 283
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
33-301 |
1.10e-08 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 55.02 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 33 EATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradaskggkhgpfvkglpFRVDYDYT 110
Cdd:cd19135 29 EAVVYALKECGYRHIDTAKRYG---CEELLGKAIKEsgVPREDLFLTTKL----------------------WPSDYGYE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 111 AdgVRRSIEDSLQRLGMARIDIAYIH--DCAEDAHGDRwlEVFDTAMKgaavALTKLREEGVIRAwgLGVN--------- 179
Cdd:cd19135 84 S--TKQAFEASLKRLGVDYLDLYLLHwpDCPSSGKNVK--ETRAETWR----ALEELYDEGLCRA--IGVSnfliehleq 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 180 -----RVEPCVMALEradpdvfllagrYSLLNQPAldELFPRCQERGVhVVVGgpynsgiiaggknfeYQEASPDKVAAR 254
Cdd:cd19135 154 lledcSVVPHVNQVE------------FHPFQNPV--ELIEYCRDNNI-VFEG---------------YCPLAKGKALEE 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2023934258 255 DRLAEIANRHGvdlRAAAlQFC----AAHPVVasVIPGTKNPPRVQENVRL 301
Cdd:cd19135 204 PTVTELAKKYQ---KTPA-QILirwsIQNGVV--TIPKSTKEERIKENCQV 248
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
26-299 |
1.22e-08 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 55.38 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 26 EVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRN--YPRDEFVLSTKVGRLLRADASKGGKHGPFVKGLpf 103
Cdd:cd19160 29 QISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSkgWRRSSYVVTTKIYWGGQAETERGLSRKHIIEGL-- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 104 rvdydytadgvrrsiEDSLQRLGMARIDIAYIHdcAEDAhgdrwlevfDTAMKGAAVALTKLREEGVIRAWGL----GVN 179
Cdd:cd19160 107 ---------------RGSLDRLQLEYVDIVFAN--RSDP---------NSPMEEIVRAMTYVINQGMAMYWGTsrwsAME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 180 RVEPCVMALE-RADPDVFLLAgRYSLLNQPALDELFPRCQER-GVHVVVGGPYNSGIIAGgknfEYQEASPD-------- 249
Cdd:cd19160 161 IMEAYSVARQfNLIPPVCEQA-EYHLFQREKVEMQLPELYHKiGVGSVTWSPLACGLITG----KYDGRVPDtcraavkg 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 250 ------KVAARD---------RLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENV 299
Cdd:cd19160 236 yqwlkeKVQSEEgkkqqakvkELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENL 300
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
13-299 |
2.24e-08 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 54.86 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGGAPLGnmfEEVPDDVAEATLVAAWDAGIRYFDTAPEY-------GPGISEHRFGHVLRNY-PRDEFVLSTKVgrll 84
Cdd:PRK10625 16 LGLGTMTFG---EQNSEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRgSREKLIIASKV---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 85 rADASKGGKHGpfvkglpFRVDYDYTADGVRRSIEDSLQRLGMARIDIAYIH------DC--------AEDAHGDRWLEV 150
Cdd:PRK10625 89 -SGPSRNNDKG-------IRPNQALDRKNIREALHDSLKRLQTDYLDLYQVHwpqrptNCfgklgyswTDSAPAVSLLET 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 151 FDtamkgaavALTKLREEGVIRAWGLGvNRVEPCVMA-LERAD----PDVFLLAGRYSLLNQPALDELFPRCQERGVHVV 225
Cdd:PRK10625 161 LD--------ALAEQQRAGKIRYIGVS-NETAFGVMRyLHLAEkhdlPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 226 ---------VGGPY-NSGIIAGGKNFEYQE----ASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVASVIPGTKN 291
Cdd:PRK10625 232 aysclafgtLTGKYlNGAKPAGARNTLFSRftrySGEQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFVASTLLGATT 311
|
....*...
gi 2023934258 292 PPRVQENV 299
Cdd:PRK10625 312 MEQLKTNI 319
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
28-300 |
2.84e-08 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 54.34 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 28 PDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNyprdefvlSTKVGRLLRAD---ASK--GGKHGPfvkglp 102
Cdd:cd19123 24 PGEVGQA-VKQALEAGYRHIDCAAIYG---NEAEIGAALAE--------VFKEGKVKREDlwiTSKlwNNSHAP------ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 103 frvdydytaDGVRRSIEDSLQRLGMARIDIAYIH-------DCAEDAHGDRWLEVFDTAMKGAAVALTKLREEGVIRAWG 175
Cdd:cd19123 86 ---------EDVLPALEKTLADLQLDYLDLYLMHwpvalkkGVGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 176 ------------LGVNRVEPCVMALERadpdvfllagrYSLLNQPALDELfprCQERGVHVVVGGPYNSGiiagGKNFEY 243
Cdd:cd19123 157 vsnfsvkkledlLATARIKPAVNQVEL-----------HPYLQQPELLAF---CRDNGIHLTAYSPLGSG----DRPAAM 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2023934258 244 QEASPDKVAARDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVR 300
Cdd:cd19123 219 KAEGEPVLLEDPVINKIAEKHGASPAQVLIAWAIQRGTV--VIPKSVNPERIQQNLE 273
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
26-176 |
1.08e-07 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 52.17 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 26 EVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLR--NYPRDEFVLSTKVgrllrADASKGgkhgpfvkglpf 103
Cdd:cd19134 20 ELSDDEAERSVSAALEAGYRLIDTAAAYG---NEAAVGRAIAasGIPRGELFVTTKL-----ATPDQG------------ 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 104 rvdYDYTADGVRRsiedSLQRLGMARIDIAYIHDCAEDAhgDRWLEVFDtamkgaavALTKLREEGVIRAWGL 176
Cdd:cd19134 80 ---FTASQAACRA----SLERLGLDYVDLYLIHWPAGRE--GKYVDSWG--------GLMKLREEGLARSIGV 135
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
32-316 |
3.38e-07 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 51.19 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 32 AEATLVAAWDAGIRYFDTAPEYGPgiSEHRFGHVL--RNYPRDEFVLSTKVGRLLRADASkggkhgpfVKGLPFRVDyDY 109
Cdd:cd19098 37 THAVLDAAWAAGVRYFDAARSYGR--AEEFLGSWLrsRNIAPDAVFVGSKWGYTYTADWQ--------VDAAVHEVK-DH 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 110 TADGVRRSIEDSLQRLGMArIDIAYIHDCAEDAhgdrwlevfdTAMKGAAV--ALTKLREEGVirAWGLGV-----NRVE 182
Cdd:cd19098 106 SLARLLKQWEETRSLLGKH-LDLYQIHSATLES----------GVLEDADVlaALAELKAEGV--KIGLSLsgpqqAETL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 183 PCVMALERADPDVF-LLAGRYSLLNQPALdELFPRCQERGVHVVVGGPYNSGIIAGGKNfeyqeaSPDKVAARDRLAEIA 261
Cdd:cd19098 173 RRALEIEIDGARLFdSVQATWNLLEQSAG-EALEEAHEAGMGVIVKEALANGRLTDRNP------SPELAPLMAVLKAVA 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 262 NRHGVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMN--------------APIPAAFWQELKQ 316
Cdd:cd19098 246 DRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDvsldlellaaladlAEPPEDYWATRSA 314
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
29-301 |
3.91e-07 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 50.32 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 29 DDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLR------NYPRDEFVLSTKVGRllradaskggkhgpfvkglp 102
Cdd:cd19136 14 EEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRdllpkyGLSREDIFITSKLAP-------------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 103 frvdYDYTADGVRRSIEDSLQRLGMARIDIAYIHdcaedahgdrW-----LEVFDTAMKGAAV----ALTKLREEGVIRA 173
Cdd:cd19136 71 ----KDQGYEKARAACLGSLERLGTDYLDLYLIH----------WpgvqgLKPSDPRNAELRReswrALEDLYKEGKLRA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 174 wgLGVNRVEPCVMALERADPDVfllagrysllnQPALD--ELFPR---------CQERGVHVVVGGPYNSGiiaggknfE 242
Cdd:cd19136 137 --IGVSNYTVRHLEELLKYCEV-----------PPAVNqvEFHPHlvqkellkfCKDHGIHLQAYSSLGSG--------D 195
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023934258 243 YQEASPDKVAArdrlaeIANRHG-----VDLRAAALQFCaahpvvaSVIPGTKNPPRVQENVRL 301
Cdd:cd19136 196 LRLLEDPTVLA------IAKKYGrtpaqVLLRWALQQGI-------GVIPKSTNPERIAENIKV 246
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
13-298 |
6.25e-07 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 50.08 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEATLVAAWDAGIRYFDTAPEY------GPGISEhrfghvlRNYPRDEFVLSTKVGRllra 86
Cdd:cd19157 13 LGLG------VFKVEEGSEVVNAVKTALKNGYRSIDTAAIYgneegvGKGIKE-------SGIPREELFITSKVWN---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 daskgGKHGpfvkglpfrvdYDYTAdgvrRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLevfdtamkgaavALTKLR 166
Cdd:cd19157 76 -----ADQG-----------YDSTL----KAFEASLERLGLDYLDLYLIHWPVKGKYKETWK------------ALEKLY 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 167 EEGVIRAwgLGVNRVEpcVMALEradpDVFLLAGRYSLLNQ----PALD--ELFPRCQERGVHVVVGGPynsgiIAGGKN 240
Cdd:cd19157 124 KDGRVRA--IGVSNFQ--VHHLE----DLLADAEIVPMVNQvefhPRLTqkELRDYCKKQGIQLEAWSP-----LMQGQL 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2023934258 241 FEyqeaspdkvaaRDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19157 191 LD-----------NPVLKEIAEKYNKSVAQVILRWDLQNGVV--TIPKSIKEHRIIEN 235
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
28-303 |
9.53e-07 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 49.69 E-value: 9.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 28 PDDVAEATLVAAwDAGIRYFDTAPEYGpgiSEHRFGHVLRnyprdEFVLSTKVGRllRAD---ASK--GGKHGPfvkglp 102
Cdd:cd19106 19 PGQVKAAVKYAL-DAGYRHIDCAAVYG---NEQEVGEALK-----EKVGPGKAVP--REDlfvTSKlwNTKHHP------ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 103 frvdydytaDGVRRSIEDSLQRLGMARIDIAYIHDCAEDAHGDrwlEVF-----------DTAMKGAAVALTKLREEGVI 171
Cdd:cd19106 82 ---------EDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGD---NPFpknpdgtirydSTHYKETWKAMEKLVDKGLV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 172 RAWGL------------GVNRVEPCVMALErADPdvfllagrysLLNQpalDELFPRCQERGVHVVVGGPYnsgiiaggk 239
Cdd:cd19106 150 KAIGLsnfnsrqiddilSVARIKPAVLQVE-CHP----------YLAQ---NELIAHCKARGLVVTAYSPL--------- 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 240 nfeyqeASPDKVAARD---------RLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRLMN 303
Cdd:cd19106 207 ------GSPDRPWAKPdepvlleepKVKALAKKYNKSPAQILLRWQVQRGVV--VIPKSVTPSRIKQNIQVFD 271
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
13-302 |
1.41e-06 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 48.94 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVgrllradask 90
Cdd:cd19127 12 LGLG------VFQTPPEETADA-VATALADGYRLIDTAAAYG---NEREVGEGIRRsgVDRSDIFVTTKL---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 ggkhgpfvkglpFRVDYDYtaDGVRRSIEDSLQRLGMARIDIAYIHDCAEDahgdrwleVFDTAMKgAAVALTKLREEGV 170
Cdd:cd19127 72 ------------WISDYGY--DKALRGFDASLRRLGLDYVDLYLLHWPVPN--------DFDRTIQ-AYKALEKLLAEGR 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAWGLGVNRVEPCVMALERAD--PDVfllagrysllNQPALDELFPRCQERGVHVVVG------GPynsgiIAGGKNFe 242
Cdd:cd19127 129 VRAIGVSNFTPEHLERLIDATTvvPAV----------NQVELHPYFSQKDLRAFHRRLGivtqawSP-----IGGVMRY- 192
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2023934258 243 yqeASPDKVAARDRL-----AEIANRHGVDLRAAALQFCAAHPVVAsvIPGTKNPPRVQENVRLM 302
Cdd:cd19127 193 ---GASGPTGPGDVLqdptiTGLAEKYGKTPAQIVLRWHLQNGVSA--IPKSVHPERIAENIDIF 252
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
13-301 |
1.86e-06 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 48.37 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFGgaplgnMFEEVPDDVAEATlVAAWDAGIRYFDTAPEYGpgiSEHRFGHVL--RNYPRDEFVLSTKVGrllradask 90
Cdd:cd19130 13 LGYG------VFKVPPADTQRAV-ATALEVGYRHIDTAAIYG---NEEGVGAAIaaSGIPRDELFVTTKLW--------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 91 GGKHGPfvkglpfrvdydytaDGVRRSIEDSLQRLGMARIDIAYIHDCAEDAhgDRWLEVFDtamkgaavALTKLREEGV 170
Cdd:cd19130 74 NDRHDG---------------DEPAAAFAESLAKLGLDQVDLYLVHWPTPAA--GNYVHTWE--------AMIELRAAGR 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 171 IRAwgLGVNRVEPcvMALERadpdVFLLAGRYSLLNQPaldELFPRCQER---------GVHVVVGGPYNSGIIAGGknf 241
Cdd:cd19130 129 TRS--IGVSNFLP--PHLER----IVAATGVVPAVNQI---ELHPAYQQRtirdwaqahDVKIEAWSPLGQGKLLGD--- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 242 eyqeaspdkvaarDRLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRL 301
Cdd:cd19130 195 -------------PPVGAIAAAHGKTPAQIVLRWHLQKGHV--VFPKSVRRERMEDNLDV 239
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
11-136 |
3.50e-06 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 47.80 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 11 GPLGFGGApLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVL---RNypRDEFVLSTKVGRLLRad 87
Cdd:cd19146 17 GAMSFGEA-WKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMasrGN--RDEMVLATKYTTGYR-- 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2023934258 88 askggKHGPfvkgLPFRVDYDYT-ADGVRRSIEDSLQRLGMARIDIAYIH 136
Cdd:cd19146 92 -----RGGP----IKIKSNYQGNhAKSLRLSVEASLKKLQTSYIDILYVH 132
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
30-176 |
8.66e-06 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 46.50 E-value: 8.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 30 DVAEATLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYPrDEFVLSTKVGRLLRADASkggkhgpfvkGLPfrvdyDY 109
Cdd:PRK10376 40 DAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIREALHPYP-DDLTIVTKVGARRGEDGS----------WLP-----AF 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2023934258 110 TADGVRRSIEDSLQRLGMARIDIAYIHdCAEDAHGDRwlevfDTAMKGAAVALTKLREEGVIRAWGL 176
Cdd:PRK10376 104 SPAELRRAVHDNLRNLGLDVLDVVNLR-LMGDGHGPA-----EGSIEEPLTVLAELQRQGLVRHIGL 164
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
30-298 |
1.92e-05 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 45.59 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 30 DVAEATLVAAW--DAGIRYFDTAPEYGpgiSEHRFGHVLRN--YPRDEFVLSTKVGrllraDASKGgkhgpfvkglpfrv 105
Cdd:cd19156 21 DGAEAENAVKWaiEAGYRHIDTAAIYK---NEEGVGQGIREsgVPREEVFVTTKLW-----NSDQG-------------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 106 dYDYTAdgvrRSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLevfdtamkgaavALTKLREEGVIRAwgLGVNRVEPC- 184
Cdd:cd19156 79 -YESTL----AAFEESLEKLGLDYVDLYLIHWPVKGKFKDTWK------------AFEKLYKEKKVRA--IGVSNFHEHh 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 185 ---VMALERADPDVFLLAgRYSLLNQPALDELfprCQERGVHVVVGGPYNSGiiaggknfeyqeaspdKVAARDRLAEIA 261
Cdd:cd19156 140 leeLLKSCKVAPMVNQIE-LHPLLTQEPLRKF---CKEKNIAVEAWSPLGQG----------------KLLSNPVLKAIG 199
|
250 260 270
....*....|....*....|....*....|....*..
gi 2023934258 262 NRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19156 200 KKYGKSAAQVIIRWDIQHGII--TIPKSVHEERIQEN 234
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
28-298 |
2.68e-05 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 45.10 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 28 PDDVAEAtLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNY------PRDEFVLSTKVGRllradaskgGKHGPfvkgl 101
Cdd:cd19154 24 GAEGITA-VRTALKAGYRLIDTAFLYQ---NEEAIGEALAELleegvvKREDLFITTKLWT---------HEHAP----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 102 pfrvdydytaDGVRRSIEDSLQRLGMARIDIAYIH------DCAEDAHGDRWLEVFDTAMKGAAV--ALTKLREEGVIRA 173
Cdd:cd19154 86 ----------EDVEEALRESLKKLQLEYVDLYLIHapaafkDDEGESGTMENGMSIHDAVDVEDVwrGMEKVYDEGLTKA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 174 WGLG---VNRVEpCVMALERADPDVFLLAgRYSLLNQPALDELfprCQERGVHVVVGGPYNSgiiAGGKNFEYQEA-SPD 249
Cdd:cd19154 156 IGVSnfnNDQIQ-RILDNARVKPHNNQVE-CHLYFPQKELVEF---CKKHNISVTSYATLGS---PGRANFTKSTGvSPA 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2023934258 250 KVAARDRLA-EIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQEN 298
Cdd:cd19154 228 PNLLQDPIVkAIAEKHGKTPAQVLLRYLLQRGIA--VIPKSATPSRIKEN 275
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
4-303 |
9.00e-05 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 43.41 E-value: 9.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 4 TQHFAPPgpLGFGGAPlgnmFEEVPDDVAEATLVAAwDAGIRYFDTAPEYGpgiSEHRFGHVLRN-------YPRDEFVL 76
Cdd:cd19124 1 SGQTMPV--IGMGTAS----DPPSPEDIKAAVLEAI-EVGYRHFDTAAAYG---TEEALGEALAEalrlglvKSRDELFV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 77 STKvgrLLRADAskggkHGPFVkgLPfrvdydytadgvrrSIEDSLQRLGMARIDIAYIHDCAEDAHGDRWLEV------ 150
Cdd:cd19124 71 TSK---LWCSDA-----HPDLV--LP--------------ALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIeeedfl 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 151 -FDtaMKGAAVALTKLREEGVIRAWG------------LGVNRVEPCVMALERaDPdvfllagrysLLNQPALDELfprC 217
Cdd:cd19124 127 pFD--IKGVWEAMEECQRLGLTKAIGvsnfsckklqelLSFATIPPAVNQVEM-NP----------AWQQKKLREF---C 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 218 QERGVHVVVGGPYNSGIIAGGknfeyqeasPDKVAARDRLAEIANRHG-----VDLRAAALQFCaahpvvaSVIPGTKNP 292
Cdd:cd19124 191 KANGIHVTAYSPLGAPGTKWG---------SNAVMESDVLKEIAAAKGktvaqVSLRWVYEQGV-------SLVVKSFNK 254
|
330
....*....|.
gi 2023934258 293 PRVQENVRLMN 303
Cdd:cd19124 255 ERMKQNLDIFD 265
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
12-290 |
1.56e-04 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 42.89 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 12 PLGFGGAPLGNMFEEV--PDDVAEA--TLVAAWDAGIRYFDTAPEYGPGISEHRFGHVLRNYP-RDEFVLSTKVGRLLRA 86
Cdd:cd19147 12 PLILGAMSIGDAWSGFmgSMDKEQAfeLLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKnRDQIVIATKFTTDYKA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 87 DASKGGKhgpfvkglpfrvDYDYTADGVRR---SIEDSLQRLGMARIDIAYIHdcaedahgdrWLEvFDTAMKGAAVALT 163
Cdd:cd19147 92 YEVGKGK------------AVNYCGNHKRSlhvSVRDSLRKLQTDWIDILYVH----------WWD-YTTSIEEVMDSLH 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 164 KLREEGviRAWGLGVNRVEPCVM------ALERADPDVFLLAGRYSLLNQPALDELFPRCQERGV-----HVVVGGPYNS 232
Cdd:cd19147 149 ILVQQG--KVLYLGVSDTPAWVVsaanyyATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMalapwDVLGGGKFQS 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2023934258 233 GIIA--------GGKNFEY-QEASPDKVAARDRLAEIANRHGVD-LRAAALQFCAAH-PVVASVIPGTK 290
Cdd:cd19147 227 KKAVeerkkngeGLRSFVGgTEQTPEEVKISEALEKVAEEHGTEsVTAIALAYVRSKaPNVFPLVGGRK 295
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
13-306 |
2.60e-04 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 41.83 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 13 LGFG-GAPLGNMFEEVPDDVAEATLVAAWDAGIRYFDTAPEYGpgiSEHRFGHVLRNY--PRDEFVLSTKVGrllradas 89
Cdd:cd19120 7 IAFGtGTAWYKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYG---NEKEVGEALKESgvPREDLFITTKVS-------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 90 KGGKHgpfvkglpfrvdydytadgVRRSIEDSLQRLGMARIDIAYIHD---CAEDAHGdrwlevFDTAMKgaavALTKLR 166
Cdd:cd19120 76 PGIKD-------------------PREALRKSLAKLGVDYVDLYLIHSpffAKEGGPT------LAEAWA----ELEALK 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 167 EEGVIRAWG------------LGVNRVEPCVMALEradpdvfllagrYSLLNQPALDELFPRCQERGvhVVVGGpYnSGI 234
Cdd:cd19120 127 DAGLVRSIGvsnfriedleelLDTAKIKPAVNQIE------------FHPYLYPQQPALLEYCREHG--IVVSA-Y-SPL 190
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 235 IAGGKNfeyqEASP-DKVaardrLAEIANRHGVDLRAAALQFCAAHPVVasVIPGTKNPPRVQENVRLMNAPI 306
Cdd:cd19120 191 SPLTRD----AGGPlDPV-----LEKIAEKYGVTPAQVLLRWALQKGIV--VVTTSSKEERMKEYLEAFDFEL 252
|
|
| PRK14863 |
PRK14863 |
bifunctional regulator KidO; Provisional |
102-314 |
2.05e-03 |
|
bifunctional regulator KidO; Provisional
Pssm-ID: 184865 [Multi-domain] Cd Length: 292 Bit Score: 39.51 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 102 PFRVDY-----DYTADGVRRSIEDSLQRLGMARIDIAYIHDCAE--DAHGDRWLEvfdtamkgaavALTKLREEGVIRAW 174
Cdd:PRK14863 71 PFRVTLstvraDRGPDFVEAEARASLRRMGVERADAILVHSPTElfGPHGAALWE-----------RLQALKDQGLFAKI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023934258 175 GLGVNRVEPCVMALERADPDVFLLAGrySLLNQ-PALDELFPRCQERGVHVVVGGPYNSGIIAggknfeyqeASPDKVAA 253
Cdd:PRK14863 140 GVSAHASDDPVGVARRFKPDILQAPA--SLLDQrLLADGSLQRIAGMGVEVHLRSIFLNGLLF---------LPPDRVPA 208
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2023934258 254 ------------RDRLAEIAnrhgVDLRAAALQFCAAHPVVASVIPGTKNPPRVQENVRLMNAPIPAAFWQEL 314
Cdd:PRK14863 209 qlkgasgrlsrvRRMIAEGR----SDPLQAALGFALSRPEGSAVLVGVNSAAELSAVVAAASSPPPDLDWDDM 277
|
|
| |
