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Conserved domains on  [gi|2038120265|ref|WP_212748507|]
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helix-turn-helix domain-containing protein [Pseudoalteromonas rubra]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-115 8.57e-48

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 148.86  E-value: 8.57e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  16 ERCPIRNVVAQIGDKWSILILFALVDGPDRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGR 95
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90       100
                  ....*....|....*....|
gi 2038120265  96 GLAKPAWQLVSWADDHFDEI 115
Cdd:COG1733    88 SLLPVLDALAEWGEEHLPEI 107
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-115 8.57e-48

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 148.86  E-value: 8.57e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  16 ERCPIRNVVAQIGDKWSILILFALVDGPDRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGR 95
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90       100
                  ....*....|....*....|
gi 2038120265  96 GLAKPAWQLVSWADDHFDEI 115
Cdd:COG1733    88 SLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 27-115 1.64e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 114.71  E-value: 1.64e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  27 IGDKWSILILFALVDGPDRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGRGLAKPAWQLVS 106
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 2038120265 107 WADDHFDEI 115
Cdd:pfam01638  82 WGEEYLEPE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 27-95 5.58e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.12  E-value: 5.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2038120265  27 IGDKWSILILFALVDGPDRFNALkSRIQGISQRMLTQTLRDLERDGYIKRTvypQVPVKVEYELTELGR 95
Cdd:cd00090     4 LSDPTRLRILRLLLEGPLTVSEL-AERLGLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
35-92 6.39e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 6.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2038120265   35 ILFALVDGPDRFNALkSRIQGISQRMLTQTLRDLERDGYIKRTVYPQvpvKVEYELTE 92
Cdd:smart00418   2 ILKLLAEGELCVCEL-AEILGLSQSTVSHHLKKLREAGLVESRREGK---RVYYSLTD 55
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
16-115 8.57e-48

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 148.86  E-value: 8.57e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  16 ERCPIRNVVAQIGDKWSILILFALVDGPDRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGR 95
Cdd:COG1733     8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGR 87

                          90       100
                  ....*....|....*....|
gi 2038120265  96 GLAKPAWQLVSWADDHFDEI 115
Cdd:COG1733    88 SLLPVLDALAEWGEEHLPEI 107
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 27-115 1.64e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 114.71  E-value: 1.64e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  27 IGDKWSILILFALVDGPDRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGRGLAKPAWQLVS 106
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 2038120265 107 WADDHFDEI 115
Cdd:pfam01638  82 WGEEYLEPE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 27-95 5.58e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.12  E-value: 5.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2038120265  27 IGDKWSILILFALVDGPDRFNALkSRIQGISQRMLTQTLRDLERDGYIKRTvypQVPVKVEYELTELGR 95
Cdd:cd00090     4 LSDPTRLRILRLLLEGPLTVSEL-AERLGLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAER 68
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
35-95 8.24e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.57  E-value: 8.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038120265  35 ILFALVDGPDRFNALKSRIqGISQRMLTQTLRDLERDGYIKRTVYpqvpvkvEYELTELGR 95
Cdd:COG4742    21 ILLLLAEGPKTRSELAESL-DVSRSTILRQLKELEERGLIERDDG-------EYELTTLGR 73
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
35-118 3.70e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.95  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038120265  35 ILFALVD-GPDRFNALkSRIQGISQRMLTQTLRDLERDGYIKRTVYPQVPVKVEYELTELGRGLAKPAWQLV-SWADDHF 112
Cdd:COG1846    43 VLAALAEaGGLTQSEL-AERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALeALLAELL 121


                  ....*.
gi 2038120265 113 DEINAA 118
Cdd:COG1846   122 AGLSEE 127
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
34-95 4.18e-03

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 34.53  E-value: 4.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038120265  34 LILFALVDGP-------DRFNALKSRIQGISQRMLTQTLRDLERDGYIKRTVYPQV--PVKVEYELTELGR 95
Cdd:COG1695    13 LILALLAEGPmygyeiiKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEggPRRKYYRLTEAGR 83
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
35-92 6.39e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 6.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2038120265   35 ILFALVDGPDRFNALkSRIQGISQRMLTQTLRDLERDGYIKRTVYPQvpvKVEYELTE 92
Cdd:smart00418   2 ILKLLAEGELCVCEL-AEILGLSQSTVSHHLKKLREAGLVESRREGK---RVYYSLTD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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