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Conserved domains on  [gi|2096255063|ref|WP_223209688|]
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MULTISPECIES: hypothetical protein [Campylobacter]

Protein Classification

nucleotidyl cyclase domain-containing protein( domain architecture ID 34085)

nucleotidyl cyclase domain-containing protein may function as a mononucleotidyl cyclase (MNC) or a diguanylate cyclase (DGC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nucleotidyl_cyc_III super family cl11967
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ...
 179-254 7.22e-04

Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.


The actual alignment was detected with superfamily member smart00267:

Pssm-ID: 448371 [Multi-domain]  Cd Length: 163  Bit Score: 39.54  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096255063  179 RLAFFDTLTKLPN--------EKSLTRFTKGKNNYIIALLHFNELKDTKESY----TKLILKQIAKILKRF-RAKIFIV- 244
Cdd:smart00267   1 RLAFRDPLTGLPNrryfeeelEQELQRAQRQGSPFALLLIDLDNFKDINDTYghavGDELLQEVAQRLSSClRPGDLLAr 80

                           90
                   ....*....|..
gi 2096255063  245 --ENDFILIFND 254
Cdd:smart00267  81 lgGDEFALLLPE 92
 
Name Accession Description Interval E-value
GGDEF smart00267
diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.
 179-254 7.22e-04

diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.


Pssm-ID: 128563 [Multi-domain]  Cd Length: 163  Bit Score: 39.54  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096255063  179 RLAFFDTLTKLPN--------EKSLTRFTKGKNNYIIALLHFNELKDTKESY----TKLILKQIAKILKRF-RAKIFIV- 244
Cdd:smart00267   1 RLAFRDPLTGLPNrryfeeelEQELQRAQRQGSPFALLLIDLDNFKDINDTYghavGDELLQEVAQRLSSClRPGDLLAr 80

                           90
                   ....*....|..
gi 2096255063  245 --ENDFILIFND 254
Cdd:smart00267  81 lgGDEFALLLPE 92
 
Name Accession Description Interval E-value
GGDEF smart00267
diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.
 179-254 7.22e-04

diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.


Pssm-ID: 128563 [Multi-domain]  Cd Length: 163  Bit Score: 39.54  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2096255063  179 RLAFFDTLTKLPN--------EKSLTRFTKGKNNYIIALLHFNELKDTKESY----TKLILKQIAKILKRF-RAKIFIV- 244
Cdd:smart00267   1 RLAFRDPLTGLPNrryfeeelEQELQRAQRQGSPFALLLIDLDNFKDINDTYghavGDELLQEVAQRLSSClRPGDLLAr 80

                           90
                   ....*....|..
gi 2096255063  245 --ENDFILIFND 254
Cdd:smart00267  81 lgGDEFALLLPE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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