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Conserved domains on  [gi|2104952194|ref|WP_224912957|]
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ATP-binding protein [Bacillus subtilis]

Protein Classification

ATP-binding protein( domain architecture ID 11482495)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-307 1.72e-157

hypothetical protein; Provisional


:

Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 439.98  E-value: 1.72e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194   7 VSIDTAFQTIMQELREKSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  87 vctpdkasewkdtysKQCECVRRKKIARLMEASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 167 IALLGQPGSGKTHLLTAIMNNLIKKKSIHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRVTDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2104952194 247 QVE-IQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSRIHQMCRDYIVIIKGDRMQLNHR 307
Cdd:PRK06921  200 QIEqMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHR 261
 
Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-307 1.72e-157

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 439.98  E-value: 1.72e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194   7 VSIDTAFQTIMQELREKSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  87 vctpdkasewkdtysKQCECVRRKKIARLMEASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 167 IALLGQPGSGKTHLLTAIMNNLIKKKSIHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRVTDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2104952194 247 QVE-IQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSRIHQMCRDYIVIIKGDRMQLNHR 307
Cdd:PRK06921  200 QIEqMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHR 261
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
63-307 1.58e-16

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 77.13  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  63 HLDEQLDLMVPDDMvSEDDFLLGKVctpdkasewkdtyskQCECVRR--KKIARLMEASGITEE--FEKLLFgNFITDGK 138
Cdd:COG1484    21 ALDELLAQAACDEL-SYEEFLALLL---------------EAEVAEReqRRIERRLKAARFPAAktLEDFDF-DAQPGLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 139 PDMIKDAYECaveyykDFqkIkgERQNSIALLGQPGSGKTHLLTAIMNNLIKKKsIHCMYFPYVEGMGDLK-ANFDN-LE 216
Cdd:COG1484    84 RRQILELATL------DF--I--ERGENLILLGPPGTGKTHLAIALGHEACRAG-YRVRFTTAPDLVNELKeARADGrLE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 217 AKLDAMRKVEVLFIDDLfkpinGQPRVTDWQVE-IQSVLNYRYlNHKPLLISSELTVDEILDI--DEALGS----RIHQM 289
Cdd:COG1484   153 RLLKRLAKVDLLILDEL-----GYLPLDAEGAElLFELISDRY-ERRSTIITSNLPFSEWGEVfgDPTLATaildRLVHH 226

                         250
                  ....*....|....*...
gi 2104952194 290 CrdYIVIIKGDRMQLNHR 307
Cdd:COG1484   227 A--HIIELKGESYRLKEA 242
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 157-286 1.38e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 52.92  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 157 QKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK------SIHCMYFPYVEGMGDLKANFDNLEAKLdAMRKVEVLFI 230
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGapflylNASDLLEGLVVAELFGHFLVRLLFELA-EKAKPGVLFI 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194 231 DDLFKPING-QPRVTDwQVEIQSVLNYRYLNHKPLLISSEltvDEILDIDEALGSRI 286
Cdd:cd00009    91 DEIDSLSRGaQNALLR-VLETLNDLRIDRENVRVIGATNR---PLLGDLDRALYDRL 143
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 162-307 2.15e-06

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 47.83  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 162 ERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSIhcmYFPYVEGM-GDLKANFDN--LEAKLDAMRKVEVLFIDDL-FKP 236
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAgYSV---RFTSAADLvNQLKRAHGDgkLTRKLQQLLKPDVLILDEWgYLP 166

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194 237 INGQPRVTDWQveiqsVLNYRYlNHKPLLISSELTVDEILDI--DEALGS----RIHQMCrdYIVIIKGDRMQLNHR 307
Cdd:pfam01695 167 LDQAEANLLFQ-----VISKRY-EHRSIILTSNLPFGEWGQVfgDAVLATaildRLLHHC--HIVPIKGESYRLKTK 235
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 163-282 4.62e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.75  E-value: 4.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  163 RQNSIALLGQPGSGKTHLLTAIMNNLIKKK-----------------SIHCMYFPYVEGMGDLKANFDNLEAKLDAmRKV 225
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggviyidgedileevldQLLLIIVGGKKASGSGELRLRLALALARK-LKP 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194  226 EVLFIDDLFKPINGQPRVTDWQVEIQSVLNYRYLNHKPLLIsseLTVDEILDIDEAL 282
Cdd:smart00382  80 DVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVI---LTTNDEKDLGPAL 133
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 171-285 1.46e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 42.90  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 171 GQPGSGKTHLLTAIMNNLIKKKS------IHCMYF--PYVEGMgdLKANFDNLEAKLdamRKVEVLFIDDL-FkpINGQP 241
Cdd:TIGR00362 144 GGVGLGKTHLLHAIGNEILENNPnakvlyVSSEKFtnDFVNAL--RNNKMEEFKEKY---RSVDLLLIDDIqF--LAGKE 216

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2104952194 242 RVtdwQVEIQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSR 285
Cdd:TIGR00362 217 RT---QEEFFHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSR 257
 
Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-307 1.72e-157

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 439.98  E-value: 1.72e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194   7 VSIDTAFQTIMQELREKSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  87 vctpdkasewkdtysKQCECVRRKKIARLMEASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 167 IALLGQPGSGKTHLLTAIMNNLIKKKSIHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRVTDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2104952194 247 QVE-IQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSRIHQMCRDYIVIIKGDRMQLNHR 307
Cdd:PRK06921  200 QIEqMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHR 261
PRK08116 PRK08116
hypothetical protein; Validated
 104-290 2.93e-20

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 88.15  E-value: 2.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 104 CECVRRK---------------KIARLMEASGITEEFEKLLFGNFITDGKPDmikDAYECAVEYYKDFQKIKGErqnSIA 168
Cdd:PRK08116   43 CECEREAeeakereeenrekqrRIERLKSNSLLDEKFRNSTFENFLFDKGSE---KAYKIARKYVKKFEEMKKE---NVG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 169 LL--GQPGSGKTHLLTAIMNNLIKKK-SIHCMYFPYVegMGDLKANF-----DNLEAKLDAMRKVEVLFIDDLfkpinGQ 240
Cdd:PRK08116  117 LLlwGSVGTGKTYLAACIANELIEKGvPVIFVNFPQL--LNRIKSTYkssgkEDENEIIRSLVNADLLILDDL-----GA 189

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2104952194 241 PRVTDWQVE-IQSVLNYRYLNHKPLLISSELTVDEILD-IDEALGSRIHQMC 290
Cdd:PRK08116  190 ERDTEWAREkVYNIIDSRYRKGLPTIVTTNLSLEELKNqYGKRIYDRILEMC 241
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
63-307 1.58e-16

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 77.13  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  63 HLDEQLDLMVPDDMvSEDDFLLGKVctpdkasewkdtyskQCECVRR--KKIARLMEASGITEE--FEKLLFgNFITDGK 138
Cdd:COG1484    21 ALDELLAQAACDEL-SYEEFLALLL---------------EAEVAEReqRRIERRLKAARFPAAktLEDFDF-DAQPGLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 139 PDMIKDAYECaveyykDFqkIkgERQNSIALLGQPGSGKTHLLTAIMNNLIKKKsIHCMYFPYVEGMGDLK-ANFDN-LE 216
Cdd:COG1484    84 RRQILELATL------DF--I--ERGENLILLGPPGTGKTHLAIALGHEACRAG-YRVRFTTAPDLVNELKeARADGrLE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 217 AKLDAMRKVEVLFIDDLfkpinGQPRVTDWQVE-IQSVLNYRYlNHKPLLISSELTVDEILDI--DEALGS----RIHQM 289
Cdd:COG1484   153 RLLKRLAKVDLLILDEL-----GYLPLDAEGAElLFELISDRY-ERRSTIITSNLPFSEWGEVfgDPTLATaildRLVHH 226

                         250
                  ....*....|....*...
gi 2104952194 290 CrdYIVIIKGDRMQLNHR 307
Cdd:COG1484   227 A--HIIELKGESYRLKEA 242
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 102-287 2.72e-15

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 74.94  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 102 KQCECVRRKKIARLMEASGITEEFEKLLFGNF--------ITDGKPDMIKDAYECAVEYYKDFQKIKGERQNSIALLGQP 173
Cdd:PRK06835  113 KKCSCYKQKLINLYYKQSNLKEILKEENFSNFnlnyysdeKDDDEPLSPRKNMEKILEKCKNFIENFDKNNENLLFYGNT 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 174 GSGKTHLLTAIMNNLIKK-KSIhcMYFPYVEGMGDLKA----NFDNLEAKLDAMRKVEVLFIDDLfkpinGQPRVTDWQV 248
Cdd:PRK06835  193 GTGKTFLSNCIAKELLDRgKSV--IYRTADELIEILREirfnNDKELEEVYDLLINCDLLIIDDL-----GTEKITEFSK 265

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2104952194 249 -EIQSVLNYRYLNHKPLLISSELTVDEILDI-DEALGSRIH 287
Cdd:PRK06835  266 sELFNLINKRLLRQKKMIISTNLSLEELLKTySERISSRLL 306
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 108-274 5.16e-11

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 62.19  E-value: 5.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 108 RRKKIARLMEASGITEEFEKLLFGNFITDGKPDMikDAYECAVEYYKDFQKikGERQNSIALLGQPGSGKTHLLTAIMNN 187
Cdd:PRK08939  104 EEKAIKKRIQSIYMPKDLLQASLADIDLDDRDRL--DALMAALDFLEAYPP--GEKVKGLYLYGDFGVGKSYLLAAIANE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 188 LiKKKSIHCM--YFPyvEGMGDLKANF--DNLEAKLDAMRKVEVLFIDDLfkpinGQPRVTDW---QVeIQSVLNYRYLN 260
Cdd:PRK08939  180 L-AKKGVSSTllHFP--EFIRELKNSIsdGSVKEKIDAVKEAPVLMLDDI-----GAEQMSSWvrdEV-LGVILQYRMQE 250

                         170
                  ....*....|....
gi 2104952194 261 HKPLLISSELTVDE 274
Cdd:PRK08939  251 ELPTFFTSNFDFDE 264
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 157-286 1.38e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 52.92  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 157 QKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK------SIHCMYFPYVEGMGDLKANFDNLEAKLdAMRKVEVLFI 230
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGapflylNASDLLEGLVVAELFGHFLVRLLFELA-EKAKPGVLFI 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194 231 DDLFKPING-QPRVTDwQVEIQSVLNYRYLNHKPLLISSEltvDEILDIDEALGSRI 286
Cdd:cd00009    91 DEIDSLSRGaQNALLR-VLETLNDLRIDRENVRVIGATNR---PLLGDLDRALYDRL 143
PRK12377 PRK12377
putative replication protein; Provisional
 89-305 3.07e-07

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 50.60  E-value: 3.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  89 TPDKASEWKDTYS-KQCECV----RRKKIARLMEASGITEEFEKLLFGNFITDGkpDMIKDAYECAVEYYKDFqkikGER 163
Cdd:PRK12377   27 TVDEWREWQLAEGrKRSEEInrqnQQLRVEKILNRSGIQPLHRKCSFANYQVQN--DGQRYALSQAKSIADEL----MTG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 164 QNSIALLGQPGSGKTHLLTAIMNNLIKK-KSIHCMYFPYVegMGDLKANFDN---LEAKLDAMRKVEVLFIDDlfkpING 239
Cdd:PRK12377  101 CTNFVFSGKPGTGKNHLAAAIGNRLLAKgRSVIVVTVPDV--MSRLHESYDNgqsGEKFLQELCKVDLLVLDE----IGI 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104952194 240 QPRVTDWQVEIQSVLNYRYLNHKPLLISSELTVDEILDIdeaLGSRIHqmcrdyiviikgDRMQLN 305
Cdd:PRK12377  175 QRETKNEQVVLNQIIDRRTASMRSVGMLTNLNHEAMSTL---LGERVM------------DRMTMN 225
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
161-285 8.08e-07

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 49.80  E-value: 8.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 161 GERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSIHCMYFPYVEGMGDLKA--NFDNLEAKLDAMRKVEVLFIDDL-Fkp 236
Cdd:COG0593    31 GKAYNPLFLYGGVGLGKTHLLHAIGNEALENnPGARVVYLTAEEFTNDFINaiRNNTIEEFKEKYRSVDVLLIDDIqF-- 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2104952194 237 INGQPRvtdWQVEIQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSR 285
Cdd:COG0593   109 LAGKEA---TQEEFFHTFNALREAGKQIVLTSDRPPKELPGLEERLRSR 154
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 108-304 1.50e-06

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 48.61  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 108 RRKKIARLMEASGITEEFEKLLFGNFITDGKPDMikDAYECAVEYYKDFqkikGERQNSIALLGQPGSGKTHLLTAIMNN 187
Cdd:PRK07952   49 RAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQM--NALSKARQYVEEF----DGNIASFIFSGKPGTGKNHLAAAICNE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 188 LI-KKKSIHCMYFPYVegMGDLKANFDNLEAK----LDAMRKVEVLFIDDlfkpINGQPRVTDWQVEIQSVLNYRYLNHK 262
Cdd:PRK07952  123 LLlRGKSVLIITVADI--MSAMKDTFSNSETSeeqlLNDLSNVDLLVIDE----IGVQTESRYEKVIINQIVDRRSSSKR 196

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2104952194 263 PLLISSELTVDEILDIdeaLGSRIHqmcrdyiviikgDRMQL 304
Cdd:PRK07952  197 PTGMLTNSNMEEMTKL---LGERVM------------DRMRL 223
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 162-307 2.15e-06

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 47.83  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 162 ERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSIhcmYFPYVEGM-GDLKANFDN--LEAKLDAMRKVEVLFIDDL-FKP 236
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAgYSV---RFTSAADLvNQLKRAHGDgkLTRKLQQLLKPDVLILDEWgYLP 166

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194 237 INGQPRVTDWQveiqsVLNYRYlNHKPLLISSELTVDEILDI--DEALGS----RIHQMCrdYIVIIKGDRMQLNHR 307
Cdd:pfam01695 167 LDQAEANLLFQ-----VISKRY-EHRSIILTSNLPFGEWGQVfgDAVLATaildRLLHHC--HIVPIKGESYRLKTK 235
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 163-282 4.62e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.75  E-value: 4.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194  163 RQNSIALLGQPGSGKTHLLTAIMNNLIKKK-----------------SIHCMYFPYVEGMGDLKANFDNLEAKLDAmRKV 225
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggviyidgedileevldQLLLIIVGGKKASGSGELRLRLALALARK-LKP 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2104952194  226 EVLFIDDLFKPINGQPRVTDWQVEIQSVLNYRYLNHKPLLIsseLTVDEILDIDEAL 282
Cdd:smart00382  80 DVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVI---LTTNDEKDLGPAL 133
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 169-285 8.83e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.51  E-value: 8.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 169 LLGQPGSGKT----HLLTAIMNnlikkksihcmyFPYVEGMG-------DLKA--NFDNLEAKL------DAMRKVEVLF 229
Cdd:pfam07728   4 LVGPPGTGKTelaeRLAAALSN------------RPVFYVQLtrdtteeDLFGrrNIDPGGASWvdgplvRAAREGEIAV 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2104952194 230 IDDLFKPingqprVTDWQVEIQSVLNYRYL------------NHKPLLISSELTVDEIL-DIDEALGSR 285
Cdd:pfam07728  72 LDEINRA------NPDVLNSLLSLLDERRLllpdggelvkaaPDGFRLIATMNPLDRGLnELSPALRSR 134
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 171-285 1.46e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 42.90  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 171 GQPGSGKTHLLTAIMNNLIKKKS------IHCMYF--PYVEGMgdLKANFDNLEAKLdamRKVEVLFIDDL-FkpINGQP 241
Cdd:TIGR00362 144 GGVGLGKTHLLHAIGNEILENNPnakvlyVSSEKFtnDFVNAL--RNNKMEEFKEKY---RSVDLLLIDDIqF--LAGKE 216

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2104952194 242 RVtdwQVEIQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSR 285
Cdd:TIGR00362 217 RT---QEEFFHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSR 257
DnaA_homol_Hda TIGR03420
DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). ...
 160-269 2.25e-04

DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274571 [Multi-domain]  Cd Length: 226  Bit Score: 41.79  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 160 KGERQNSIALLGQPGSGKTHLLTAIMNNLIKKKSiHCMYFPyvegMGDLKanfDNLEAKLDAMRKVEVLFIDDLFKpING 239
Cdd:TIGR03420  34 AGKGDRFLYLWGESGSGKSHLLQAACAAAEERGK-SAIYLP----LAELA---QADPEVLEGLEQADLVCLDDVEA-IAG 104

                          90       100       110
                  ....*....|....*....|....*....|
gi 2104952194 240 QPrvtDWQVEIQSVLNYRYLNHKPLLISSE 269
Cdd:TIGR03420 105 QP---EWQEALFHLYNRVREAGGRLLIAGR 131
Bac_DnaA pfam00308
Bacterial dnaA protein;
161-285 4.86e-04

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 40.77  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 161 GERQNSIALLGQPGSGKTHLLTAIMNNLIKKKS------IHCMYF--PYVEGMGDLKAN-FDNleakldAMRKVEVLFID 231
Cdd:pfam00308  31 GKAYNPLFIYGGVGLGKTHLLHAIGNYALQNAPnlrvvyLTAEEFlnDFVDAIRDNKTNqFKE------KYRNVDVLLID 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2104952194 232 DL-FkpINGQPRVtdwQVEIQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSR 285
Cdd:pfam00308 105 DIqF--LAGKEGT---QEEFFHTFNALHESGKQIVFSSDRPPKELEELEDRLRSR 154
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 156-297 1.26e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.02  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 156 FQKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK----SIHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVL--- 228
Cdd:pfam13191  16 LDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERDGgyflRGKCDENLPYSPLLEALTREGLLRQLLDELESSLLEawr 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104952194 229 -FIDDLFKPINGQPRVTDWQV--EIQSVLNYRYLNHKPLLIsselTVDEILDIDEA----LGSRIHQMCRDYIVII 297
Cdd:pfam13191  96 aALLEALAPVPELPGDLAERLldLLLRLLDLLARGERPLVL----VLDDLQWADEAslqlLAALLRLLESLPLLVV 167
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 165-268 2.40e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 38.40  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 165 NSIALLGQPGSGKThllTAIMNNLIK--KKSIHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPR 242
Cdd:cd01124    20 SVTLLTGGPGTGKT---LFGLQFLYAgaKNGEPGLFFTFEESPERLLRNAKSFGWDFDEMEDEGKLIIVDAPPTEAGRFS 96

                          90       100
                  ....*....|....*....|....*.
gi 2104952194 243 VTDWQVEIQSVLNYRylNHKPLLISS 268
Cdd:cd01124    97 LDELLSRILSIIKSF--KAKRVVIDS 120
dnaA PRK00149
chromosomal replication initiator protein DnaA;
165-285 2.79e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 38.96  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104952194 165 NSIALLGQPGSGKTHLLTAIMNNLIKKKS------IHCMYFpyvegMGDL-----KANFDNLEAKLdamRKVEVLFIDDL 233
Cdd:PRK00149  100 NPLFIYGGVGLGKTHLLHAIGNYILEKNPnakvvyVTSEKF-----TNDFvnalrNNTMEEFKEKY---RSVDVLLIDDI 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2104952194 234 -FkpINGQPRVtdwQVEIQSVLNYRYLNHKPLLISSELTVDEILDIDEALGSR 285
Cdd:PRK00149  172 qF--LAGKERT---QEEFFHTFNALHEAGKQIVLTSDRPPKELPGLEERLRSR 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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