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Conserved domains on  [gi|2119195094|ref|WP_226679310|]
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class I SAM-dependent methyltransferase [Mesobacillus jeotgali]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11457987)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Methanocaldococcus jannaschii S-adenosylmethionine-dependent methyltransferase MJ0882

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 10-199 7.60e-83

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 243.56  E-value: 7.60e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  10 PSTESNPAKWHSELKGNSFRFKTDTGVFSKKEVDFGSRLLIDTFELNkVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVD 89
Cdd:COG2813     2 PAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHLPEP-LGGRVLDLGCGYGVIGLALAKRNPEARVTLVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  90 VNERAIMLAEENASENKVNNVRIYESDRLTGVEEKGFDAILTNPPIRAG----KKIVHDIFEQSFLHLAEGGELWVVIQK 165
Cdd:COG2813    81 VNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVANR 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2119195094 166 KQgapSAMEKMKELFGEVDIAAKSKGYFILKSVK 199
Cdd:COG2813   161 HL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 10-199 7.60e-83

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 243.56  E-value: 7.60e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  10 PSTESNPAKWHSELKGNSFRFKTDTGVFSKKEVDFGSRLLIDTFELNkVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVD 89
Cdd:COG2813     2 PAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHLPEP-LGGRVLDLGCGYGVIGLALAKRNPEARVTLVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  90 VNERAIMLAEENASENKVNNVRIYESDRLTGVEEKGFDAILTNPPIRAG----KKIVHDIFEQSFLHLAEGGELWVVIQK 165
Cdd:COG2813    81 VNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVANR 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2119195094 166 KQgapSAMEKMKELFGEVDIAAKSKGYFILKSVK 199
Cdd:COG2813   161 HL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 28-196 1.71e-68

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 206.67  E-value: 1.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  28 FRFKTDTGVFSKKEVDFGSRLLIDTFELNKvDGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKV 107
Cdd:pfam05175   2 LTFKTLPGVFSHGRLDIGSRLLLEHLPKDL-SGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 108 NNVRIYESDRLTGVEEKGFDAILTNPPIRAGKK----IVHDIFEQSFLHLAEGGELWVVIQKKQGAPSAMEkmkELFGEV 183
Cdd:pfam05175  81 ENGEVVASDVYSGVEDGKFDLIISNPPFHAGLAttynVAQRFIADAKRHLRPGGELWIVANRFLGYPPLLE---ELFGNV 157

                         170
                  ....*....|...
gi 2119195094 184 DIAAKSKGYFILK 196
Cdd:pfam05175 158 EVVAKTNGFKVLK 170
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 62-199 3.53e-22

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 90.61  E-value: 3.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESDRLTGVEEKGFDAILTNPP-IRAGKK 140
Cdd:PRK09328  112 VLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPyIPEADI 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 141 ------------------------IVHDIFEQSFLHLAEGGELWVVIQKKQGapsamEKMKELFgevdiaaKSKGYFILK 196
Cdd:PRK09328  192 hllqpevrdhephlalfggedgldFYRRIIEQAPRYLKPGGWLLLEIGYDQG-----EAVRALL-------AAAGFADVE 259


                  ...
gi 2119195094 197 SVK 199
Cdd:PRK09328  260 TRK 262
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-163 1.10e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.77  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKaYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESD--RLTGVEEKGFDAILTNPPIRAGK 139
Cdd:cd02440     2 VLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDaeELPPEADESFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|....
gi 2119195094 140 KIVHDIFEQSFLHLAEGGELWVVI 163
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTL 104
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 62-134 5.29e-16

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 74.31  E-value: 5.29e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVN-NVRIYESDRLTGVEEKGFDAILTNPP 134
Cdd:TIGR00536 118 ILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEhRVEFIQSNLFEPLAGQKIDIIVSNPP 191
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 10-199 7.60e-83

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 243.56  E-value: 7.60e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  10 PSTESNPAKWHSELKGNSFRFKTDTGVFSKKEVDFGSRLLIDTFELNkVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVD 89
Cdd:COG2813     2 PAASDWPRTITVRLAGRDLTFVTLPGVFSRDRLDIGTRLLLEHLPEP-LGGRVLDLGCGYGVIGLALAKRNPEARVTLVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  90 VNERAIMLAEENASENKVNNVRIYESDRLTGVEEKGFDAILTNPPIRAG----KKIVHDIFEQSFLHLAEGGELWVVIQK 165
Cdd:COG2813    81 VNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPFHAGravdKEVAHALIADAARHLRPGGELWLVANR 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2119195094 166 KQgapSAMEKMKELFGEVDIAAKSKGYFILKSVK 199
Cdd:COG2813   161 HL---PYERKLEELFGNVEVLARNKGFKVLRAVK 191
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 28-196 1.71e-68

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 206.67  E-value: 1.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  28 FRFKTDTGVFSKKEVDFGSRLLIDTFELNKvDGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKV 107
Cdd:pfam05175   2 LTFKTLPGVFSHGRLDIGSRLLLEHLPKDL-SGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 108 NNVRIYESDRLTGVEEKGFDAILTNPPIRAGKK----IVHDIFEQSFLHLAEGGELWVVIQKKQGAPSAMEkmkELFGEV 183
Cdd:pfam05175  81 ENGEVVASDVYSGVEDGKFDLIISNPPFHAGLAttynVAQRFIADAKRHLRPGGELWIVANRFLGYPPLLE---ELFGNV 157

                         170
                  ....*....|...
gi 2119195094 184 DIAAKSKGYFILK 196
Cdd:pfam05175 158 EVVAKTNGFKVLK 170
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 62-199 3.53e-22

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 90.61  E-value: 3.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESDRLTGVEEKGFDAILTNPP-IRAGKK 140
Cdd:PRK09328  112 VLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPyIPEADI 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 141 ------------------------IVHDIFEQSFLHLAEGGELWVVIQKKQGapsamEKMKELFgevdiaaKSKGYFILK 196
Cdd:PRK09328  192 hllqpevrdhephlalfggedgldFYRRIIEQAPRYLKPGGWLLLEIGYDQG-----EAVRALL-------AAAGFADVE 259


                  ...
gi 2119195094 197 SVK 199
Cdd:PRK09328  260 TRK 262
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
31-162 4.37e-22

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 91.54  E-value: 4.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  31 KTDTGVFSKKEVDFGSRLLIDTFElNKVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNv 110
Cdd:PRK09489  170 KTLPGVFSRDGLDVGSQLLLSTLT-PHTKGKVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEG- 247

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2119195094 111 RIYESDRLTGVEEKgFDAILTNPP----IRAGKKIVHDIFEQSFLHLAEGGELWVV 162
Cdd:PRK09489  248 EVFASNVFSDIKGR-FDMIISNPPfhdgIQTSLDAAQTLIRGAVRHLNSGGELRIV 302
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 62-161 5.36e-21

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 87.51  E-value: 5.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNN-VRIYESDRLTGVEEKG-FDAILTNPP-IRA- 137
Cdd:COG2890   116 VLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLPGDGrFDLIVSNPPyIPEd 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2119195094 138 -----------------------GKKIVHDIFEQSFLHLAEGGELWV 161
Cdd:COG2890   196 eiallppevrdheprlaldggedGLDFYRRIIAQAPRLLKPGGWLLL 242
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
9-199 5.09e-20

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 86.23  E-value: 5.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094   9 KPSTESNPAKWHSELKGNSFRFKTDTGVFSKKEVDFGSRLLIDTFELNkVDGLILDVGCGYGPIGLSLAKAYPEAMVHMV 88
Cdd:PRK15001  180 EPPLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGARFFMQHLPEN-LEGEIVDLGCGNGVIGLTLLDKNPQAKVVFV 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  89 DVNERAIMLAEENASEN---KVNNVRIYESDRLTGVEEKGFDAILTNPPIRAGKKIVHDIFEQSFLH----LAEGGELWV 161
Cdd:PRK15001  259 DESPMAVASSRLNVETNmpeALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQHALTDNVAWEMFHHarrcLKINGELYI 338

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2119195094 162 VIQKKQgapSAMEKMKELFGEVDIAAKSKGYFILKSVK 199
Cdd:PRK15001  339 VANRHL---DYFHKLKKIFGNCTTIATNNKFVVLKAVK 373
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-163 1.10e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.77  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKaYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESD--RLTGVEEKGFDAILTNPPIRAGK 139
Cdd:cd02440     2 VLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDaeELPPEADESFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|....
gi 2119195094 140 KIVHDIFEQSFLHLAEGGELWVVI 163
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLTL 104
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 62-134 5.29e-16

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 74.31  E-value: 5.29e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVN-NVRIYESDRLTGVEEKGFDAILTNPP 134
Cdd:TIGR00536 118 ILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEhRVEFIQSNLFEPLAGQKIDIIVSNPP 191
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-193 4.14e-15

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 69.93  E-value: 4.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  46 SRLLIDTFeLNKVDGLILDVGCGYGPIGLSLAKAypEAMVHMVDVNERAIMLAEENASENKVNN--VRIYESDRLTGVEE 123
Cdd:PRK14968   12 SFLLAENA-VDKKGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDLFEPFRG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 124 KGFDAILTNPPI--------------------RAGKKIVHDIFEQSFLHLAEGGELWVVIQKKQGAPSAMEKMKELFGEV 183
Cdd:PRK14968   89 DKFDVILFNPPYlpteeeeewddwlnyalsggKDGREVIDRFLDEVGRYLKPGGRILLLQSSLTGEDEVLEYLEKLGFEA 168

                         170
                  ....*....|
gi 2119195094 184 DIAAKSKGYF 193
Cdd:PRK14968  169 EVVAEEKFPF 178
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 62-163 1.48e-14

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 69.40  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNN-VRIYESD---RLTGVEEKGFDAILTNPP--- 134
Cdd:COG4123    41 VLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDlkeFAAELPPGSFDLVVSNPPyfk 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2119195094 135 -------IRAGKKIVH--------DIFEQSFLHLAEGGELWVVI 163
Cdd:COG4123   121 agsgrksPDEARAIARhedaltleDLIRAAARLLKPGGRFALIH 164
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 62-138 8.02e-12

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 62.89  E-value: 8.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAypEAMVHMVDVNERAIMLAEENASENKVNNVRIYESD---RLTGVEEKG-FDAILTNPPiRA 137
Cdd:COG2265   237 VLDLYCGVGTFALPLARR--AKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDleeVLPELLWGGrPDVVVLDPP-RA 313


                  .
gi 2119195094 138 G 138
Cdd:COG2265   314 G 314
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-167 7.09e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.77  E-value: 7.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  47 RLLIDTFELNKvDGLILDVGCGYGPIGLSLAKAYpEAMVHMVDVNERAIMLAEENASENKVNNVRIYESD--RLTGVEEK 124
Cdd:COG0500    16 ALLALLERLPK-GGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADlaELDPLPAE 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2119195094 125 GFDAIL-------TNPPIRagKKIVHDIFEqsflHLAEGGELWVVIQKKQ 167
Cdd:COG0500    94 SFDLVVafgvlhhLPPEER--EALLRELAR----ALKPGGVLLLSASDAA 137
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 62-157 6.28e-10

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 57.18  E-value: 6.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPeAMVHMVDVNERAIMLAEENASENKV-NNVRIYESD--RLTGVEEKGFDAILTNPPIRAg 138
Cdd:COG2520   184 VLDMFAGVGPFSIPIAKRSG-AKVVAIDINPDAVEYLKENIRLNKVeDRVTPILGDarEVAPELEGKADRIIMNLPHSA- 261

                          90
                  ....*....|....*....
gi 2119195094 139 kkivHDIFEQSFLHLAEGG 157
Cdd:COG2520   262 ----DEFLDAALRALKPGG 276
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-132 8.81e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.72  E-value: 8.81e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYpEAMVHMVDVNERAIMLAEENASENKVnNVRIYESD-RLTGVEEKGFDAILTN 132
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDaEDLPFPDGSFDLVVSS 70
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 30-185 1.89e-09

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 55.94  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  30 FKTDTGVFSKKEVdfgsRLLIdtfeLNKV----DGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASEN 105
Cdd:COG2242   223 FERDKGPITKREV----RALT----LAKLalrpGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRF 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 106 KVNNVRIYE---SDRLTGVEEkgFDAILtnppIRAGKKIVHDIFEQSFLHLAEGGELwVV----IqkkQGAPSAMEKMKE 178
Cdd:COG2242   295 GVPNVEVVEgeaPEALADLPD--PDAVF----IGGSGGNLPEILEACWARLRPGGRL-VAnavtL---ETLALALEALAE 364


                  ....*..
gi 2119195094 179 LFGEVDI 185
Cdd:COG2242   365 LGYGGEL 371
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 62-193 2.51e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 53.57  E-value: 2.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLA-KAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESDRL---TGVEEKGFDAILTNPPIRA 137
Cdd:pfam13847   7 VLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEelpELLEDDKFDVVISNCVLNH 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2119195094 138 GKKIVhDIFEQSFLHLAEGGELWVV-IQKKQGAPSAMEKMKELFGEVDIAAKSKGYF 193
Cdd:pfam13847  87 IPDPD-KVLQEILRVLKPGGRLIISdPDSLAELPAHVKEDSTYYAGCVGGAILKKKL 142
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
62-132 1.79e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.51  E-value: 1.79e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASenkvnNVRIYESDRLTGVEEKGFDAILTN 132
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP-----NVRFVVADLRDLDPPEPFDLVVSN 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 62-132 1.51e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.39  E-value: 1.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYPEamVHMVDVNERAIMLAEENASEnkvNNVRIYESD-RLTGVEEKGFDAILTN 132
Cdd:COG2227    28 VLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARERAAE---LNVDFVQGDlEDLPLEDGSFDLVICS 94
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 29-134 2.02e-06

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 47.17  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  29 RFKTDTGVFSKKEVDFGSRLLIDTFELNKVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVN 108
Cdd:PRK01544  109 CHSRESGNPEKKQLNPCFRGNDISSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVT 188

                          90       100
                  ....*....|....*....|....*..
gi 2119195094 109 N-VRIYESDRLTGVEEKGFDAILTNPP 134
Cdd:PRK01544  189 DrIQIIHSNWFENIEKQKFDFIVSNPP 215
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
38-159 2.03e-06

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 46.15  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  38 SKKEVdfgsRLL-IDTFELNKVDGLIlDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESD 116
Cdd:PRK08287   15 TKEEV----RALaLSKLELHRAKHLI-DVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIPGE 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2119195094 117 RLTGVEEKgFDAI--------LTnppiragkkivhDIFEQSFLHLAEGGEL 159
Cdd:PRK08287   90 APIELPGK-ADAIfiggsggnLT------------AIIDWSLAHLHPGGRL 127
PRK14967 PRK14967
putative methyltransferase; Provisional
 46-162 2.92e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 46.20  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  46 SRLLIDTFELNKVD--GLILDVGCGYGPIGLSLAKAYPEAmVHMVDVNERAIMLAEENASENKVNnVRIYESDRLTGVEE 123
Cdd:PRK14967   22 TQLLADALAAEGLGpgRRVLDLCTGSGALAVAAAAAGAGS-VTAVDISRRAVRSARLNALLAGVD-VDVRRGDWARAVEF 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2119195094 124 KGFDAILTNPPI--------------RA------GKKIVHDIFEQSFLHLAEGGELWVV 162
Cdd:PRK14967  100 RPFDVVVSNPPYvpappdappsrgpaRAwdagpdGRAVLDRLCDAAPALLAPGGSLLLV 158
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
46-134 3.38e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 45.67  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  46 SRLLIDTFELNKVDG-LILDVGCGYG--PIGLSLAKAypeAMVHMVDVNERAIMLAEENASENKVnNVRIYESDRLTGVE 122
Cdd:COG2263    32 AELLHLAYLRGDIEGkTVLDLGCGTGmlAIGAALLGA---KKVVGVDIDPEALEIARENAERLGV-RVDFIRADVTRIPL 107

                          90
                  ....*....|..
gi 2119195094 123 EKGFDAILTNPP 134
Cdd:COG2263   108 GGSVDTVVMNPP 119
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-159 7.81e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 43.13  E-value: 7.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  63 LDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESDRLTGVEEKG--FDAILTN------PP 134
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPgsFDVVVASnvlhhlAD 80

                          90       100
                  ....*....|....*....|....*
gi 2119195094 135 IRAgkkivhdIFEQSFLHLAEGGEL 159
Cdd:pfam08242  81 PRA-------VLRNIRRLLKPGGVL 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 62-132 1.77e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.06  E-value: 1.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2119195094  62 ILDVGCGYGPIGLSLAKAypEAMVHMVDVNERAIMLAEENASENKVnNVRIYESD-RLTGVEEKGFDAILTN 132
Cdd:COG2226    26 VLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL-NVEFVVGDaEDLPFPDGSFDLVISS 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
59-157 3.00e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.68  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  59 DGLILDVGCGYGPIGLSLAKAYPEamVHMVDVNERAIMLAEENASEnkvnnVRIYESD-RLTGVEEKGFDAILTN---PP 134
Cdd:COG4976    47 FGRVLDLGCGTGLLGEALRPRGYR--LTGVDLSEEMLAKAREKGVY-----DRLLVADlADLAEPDGRFDLIVAAdvlTY 119

                          90       100
                  ....*....|....*....|...
gi 2119195094 135 IRAGKKIVHDIFEqsflHLAEGG 157
Cdd:COG4976   120 LGDLAAVFAGVAR----ALKPGG 138
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 24-147 1.08e-04

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 41.18  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  24 KGNSFRFKTDtgvFSKkeVDFGSRL------LIDTFELNKVdglILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIML 97
Cdd:pfam02475  67 KENGCRFKVD---VAK--VYWSPRLiaererIAKLVEPGEV---VVDMFAGIGPFSIPIAKHSKARRVYAIELNPESYKY 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2119195094  98 AEENASENKVNN-VRIYESDRLTGVEEKGFDAILTNPPIRAgKKIVHDIFE 147
Cdd:pfam02475 139 LKENIKLNKVEDvVKPILGDVREVILEDVADRVVMNLPGSA-HEFLDKAFA 188
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
54-159 1.30e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 41.70  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  54 ELNKVDGLILDVGCGYGpIgLSLAkaypeAM------VHMVDVNERAIMLAEENASENKV-NNVRIYESDrltGVEEKGF 126
Cdd:COG2264   144 KLLKPGKTVLDVGCGSG-I-LAIA-----AAklgakrVLAVDIDPVAVEAARENAELNGVeDRIEVVLGD---LLEDGPY 213

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2119195094 127 DAILTNppIRAG--KKIVHDIFEqsflHLAEGGEL 159
Cdd:COG2264   214 DLVVAN--ILANplIELAPDLAA----LLKPGGYL 242
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 88-155 1.38e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 40.70  E-value: 1.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2119195094  88 VDVNERAIMLAEENASENKVNNVRIYESD--RLTGVEEKgFDAILTNPP----IRAGKKIVHDIFEQSFLHLAE 155
Cdd:COG1041    54 SDIDPKMVEGARENLEHYGYEDADVIRGDarDLPLADES-VDAIVTDPPygrsSKISGEELLELYEKALEEAAR 126
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
38-159 1.94e-04

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 40.75  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  38 SKKEVdfgsRLLIDTFELNKVDGLILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYEsdr 117
Cdd:PRK07402   24 TKREV----RLLLISQLRLEPDSVLWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIE--- 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2119195094 118 ltGVEEKGFDAILTNPP---IRAGKKIvHDIFEQSFLHLAEGGEL 159
Cdd:PRK07402   97 --GSAPECLAQLAPAPDrvcIEGGRPI-KEILQAVWQYLKPGGRL 138
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 54-157 2.21e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 41.10  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  54 ELNKVDGLILDVGCGYGpIgLSLAKAYPEAM-VHMVDVNERAIMLAEENASENKVN-NVRIYESDRLtgVEEKgFDAILT 131
Cdd:pfam06325 157 RLVKPGESVLDVGCGSG-I-LAIAALKLGAKkVVGVDIDPVAVRAAKENAELNGVEaRLEVYLPGDL--PKEK-ADVVVA 231

                          90       100
                  ....*....|....*....|....*....
gi 2119195094 132 N---PPIRAgkkIVHDIFEqsflHLAEGG 157
Cdd:pfam06325 232 NilaDPLIE---LAPDIYA----LVKPGG 253
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 62-130 2.22e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.91  E-value: 2.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKAYpEAMVHMVDVNERAIMLAEENASENKV-NNVRIYESDRLTGVEEKGFDAIL 130
Cdd:COG2230    55 VLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLaDRVEVRLADYRDLPADGQFDAIV 123
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 62-129 5.08e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 39.76  E-value: 5.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  62 ILDVGCGYGPIGLSLAKA-YPEAMVHMVDVNERAIMLAEENASE-NKVNNVRIYESDRLTGVEEKGFDAI 129
Cdd:COG2519    95 VLEAGTGSGALTLALARAvGPEGKVYSYERREDFAEIARKNLERfGLPDNVELKLGDIREGIDEGDVDAV 164
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 60-197 8.59e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 38.62  E-value: 8.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  60 GLILDVGCGYGPIGLSLAKAYPE-AMVHMVDVNERAIMLAEENASENKV-NNVRIYESDR---LTGVEEKgFDAILtnpp 134
Cdd:PRK00377   42 DMILDIGCGTGSVTVEASLLVGEtGKVYAVDKDEKAINLTRRNAEKFGVlNNIVLIKGEApeiLFTINEK-FDRIF---- 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094 135 IRAGKKIVHDIFEQSFLHLAEGGEL---WVVIQKKQGAPSAMEKM--KELFGEVDIAA--KSKGYFILKS 197
Cdd:PRK00377  117 IGGGSEKLKEIISASWEIIKKGGRIvidAILLETVNNALSALENIgfNLEITEVIIAKgmKTKVGTAMMT 186
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-132 1.06e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.87  E-value: 1.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  63 LDVGCGYGPIGLSLAKAYPEamVHMVDVNERAIMLAEENASENKVNNVRiyESDRLTGVEEKGFDAILTN 132
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPREGLTFVV--GDAEDLPFPDNSFDLVLSS 66
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 85-159 1.22e-03

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 39.01  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119195094  85 VHMVDVNERAIMLAEENASENKVN-NVRIYESD------RLTGVEEKgFDAILTNPP--------IRAGKKIVHDIFEQS 149
Cdd:COG1092   242 VTSVDLSATALEWAKENAALNGLDdRHEFVQADafdwlrELAREGER-FDLIILDPPafakskkdLFDAQRDYKDLNRLA 320

                          90
                  ....*....|
gi 2119195094 150 FLHLAEGGEL 159
Cdd:COG1092   321 LKLLAPGGIL 330
PRK06202 PRK06202
hypothetical protein; Provisional
 62-132 1.25e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 38.44  E-value: 1.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2119195094  62 ILDVGCGYGPIGLSLAK-AYPEAM---VHMVDVNERAIMLAEENASENKVnNVRIYESDRLtgVEE-KGFDAILTN 132
Cdd:PRK06202   64 LLDIGCGGGDLAIDLARwARRDGLrleVTAIDPDPRAVAFARANPRRPGV-TFRQAVSDEL--VAEgERFDVVTSN 136
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 61-119 8.82e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 35.73  E-value: 8.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2119195094  61 LILDVGCGYGPIGLSLAKAYPEAMVHMVDVNERAIMLAEENASENKVNNVRIYESDRLT 119
Cdd:pfam02390   4 VFLEIGCGMGGFLVAMAKANPDKNFIGIEIRVPGVAKALKKIDALGLQNLRILCGNALD 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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