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Conserved domains on  [gi|2124029328|ref|WP_226980843|]
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Rid family detoxifying hydrolase [Vibrio lentus]

Protein Classification

RidA family protein( domain architecture ID 817)

RidA (reactive intermediate/imine deaminase A) family protein

PubMed:  25975565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_family super family cl10015
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 2-128 8.98e-55

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


The actual alignment was detected with superfamily member TIGR00004:

Pssm-ID: 447879  Cd Length: 124  Bit Score: 167.47  E-value: 8.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   2 RKIIDTQAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2124029328  82 MMSFAVVNEIYNDFFIKNganfFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEH----YPARSAVQVAALPKGVLVEIEAIAV 123
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 2-128 8.98e-55

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 167.47  E-value: 8.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   2 RKIIDTQAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2124029328  82 MMSFAVVNEIYNDFFIKNganfFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEH----YPARSAVQVAALPKGVLVEIEAIAV 123
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-130 2.98e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 158.42  E-value: 2.98e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   1 MRKIIDTqAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKnTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLT 80
Cdd:COG0251     2 TRELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGG-DIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2124029328  81 DMMSFAVVNEIYNDFFiknGANfFPARTCIEVSKLPLAALIEIEAVAVSP 130
Cdd:COG0251    80 DMADFAAVNEVYAEYF---GEG-RPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 9-128 1.05e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 148.99  E-value: 1.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   9 AAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVV 88
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2124029328  89 NEIYNDFFiknGANFFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:pfam01042  81 NEVYAEYF---DADKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 17-127 3.08e-45

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 142.70  E-value: 3.08e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTGLlVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVVNEIYNDFF 96
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDGEL-VPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2124029328  97 iknGANFFPARTCIEVSKLPLAALIEIEAVA 127
Cdd:cd00448    80 ---GEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
1-128 1.47e-39

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 129.03  E-value: 1.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   1 MRKIIDTQAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEkQTLQCLENMRAILLHADADMSDVVKTTVYLT 80
Cdd:PRK11401    1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQD-QARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2124029328  81 DMMSFAVVNEIYNDFFIKNGANfFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:PRK11401   80 DLNDFATINEVYKQFFDEHQAT-YPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 2-128 8.98e-55

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 167.47  E-value: 8.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   2 RKIIDTQAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTD 81
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2124029328  82 MMSFAVVNEIYNDFFIKNganfFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEH----YPARSAVQVAALPKGVLVEIEAIAV 123
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-130 2.98e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 158.42  E-value: 2.98e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   1 MRKIIDTqAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKnTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLT 80
Cdd:COG0251     2 TRELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGG-DIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2124029328  81 DMMSFAVVNEIYNDFFiknGANfFPARTCIEVSKLPLAALIEIEAVAVSP 130
Cdd:COG0251    80 DMADFAAVNEVYAEYF---GEG-RPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 9-128 1.05e-47

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 148.99  E-value: 1.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   9 AAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVV 88
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2124029328  89 NEIYNDFFiknGANFFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:pfam01042  81 NEVYAEYF---DADKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 17-127 3.08e-45

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 142.70  E-value: 3.08e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTGLlVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVVNEIYNDFF 96
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDGEL-VPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2124029328  97 iknGANFFPARTCIEVSKLPLAALIEIEAVA 127
Cdd:cd00448    80 ---GEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
1-128 1.47e-39

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 129.03  E-value: 1.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   1 MRKIIDTQAAPKAIGPYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEkQTLQCLENMRAILLHADADMSDVVKTTVYLT 80
Cdd:PRK11401    1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQD-QARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2124029328  81 DMMSFAVVNEIYNDFFIKNGANfFPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:PRK11401   80 DLNDFATINEVYKQFFDEHQAT-YPTRSCVQVARLPKDVKLEIEAIAV 126
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 12-127 2.45e-19

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 77.21  E-value: 2.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  12 KAIGpYSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEkQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVVNEI 91
Cdd:cd06154     9 EQAG-YSRAVRVGNWVFVSGTTGYDYDGMVMPGDAYE-QTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRA 86

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2124029328  92 YNDFFikngANFFPARTCIEVSKLP-LAALIEIEAVA 127
Cdd:cd06154    87 HGEVF----GDIRPAATMVVVSLLVdPEMLVEIEVTA 119
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 17-128 2.63e-19

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 76.81  E-value: 2.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTgllvknTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVVNEIYNDFF 96
Cdd:cd06150     3 MSQAVVHNGTVYLAGQVADDTSA------DITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2124029328  97 IKNGAnffPARTCIEVSKLPLAALIEIEAVAV 128
Cdd:cd06150    77 PPGHA---PARACVEAKLADPGYLVEIVVTAA 105
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 17-128 1.16e-17

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 72.68  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTGllVKNTLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMS-FAVVNEIYNDF 95
Cdd:cd02198     3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMAAhLPAFAAVKDEY 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2124029328  96 FiKNGanfFPARTCIEVSKL--PlAALIEIEAVAV 128
Cdd:cd02198    81 F-KEP---YPAWTAVGVAWLarP-GLLVEIKVVAV 110
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-127 2.36e-16

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 69.66  E-value: 2.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  18 SQGV-ITGG--LIFTSGQLP------LSPHTGLLVKNTlEKQTLQCLENMRAILLHADADMSDVVKTTVYL------TDM 82
Cdd:cd06151     2 AQAVeVPAGaaTIYLSGTVPavvnasAPKGSPARYGDT-ETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2124029328  83 MSFAVVNEIYNDFF-IKNGANfFPARTCIEVSKLPLA-ALIEIEAVA 127
Cdd:cd06151    81 MDFAGFMKAYRQFFgTAEQPN-KPARSTLQVAGLVNPgWLVEIEVVA 126
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 46-127 2.40e-13

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 61.12  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  46 TLEKQTLQCLENMRAILLHADADMSDVVKTTVYLTDMMSFAVVNEIYNDFFIKNGAnffPARTCIEvSKLPLAALIEIEA 125
Cdd:cd06155    23 TVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNP---PSRVCVE-CGLPEGCDVQLSC 98


                  ..
gi 2124029328 126 VA 127
Cdd:cd06155    99 VA 100
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 17-128 5.28e-10

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 53.08  E-value: 5.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTGlLVKNTLEKQTLQCLENMRAILLHAD-ADMSDVVKTTVYLTDMMsfavvNEIYNDF 95
Cdd:cd06152     3 YSQAVRIGDRIEISGQGGWDPDTG-KIPEDLEEEIDQAFDNVELALKAAGgKGWEQVYKVNSYHVDIK-----NEEAFGL 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2124029328  96 FIKNGANFFPAR----TCIEVSKLPLAAL-IEIEAVAV 128
Cdd:cd06152    77 MVENFKKWMPNHqpiwTCVGVTALGLPGMrVEIEVDAI 114
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 17-127 1.65e-09

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 51.56  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  17 YSQGVITGGLIFTSGQLPLSPHTGLLVKNTLEKQTLQCLENMRAIllhADA-DMSDVVKTTVYLTDMMSFAVVNEIYnDF 95
Cdd:cd06156     1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERV---AKAmNVQWVLAAVCYVTDESSVPIARSAW-SK 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2124029328  96 FIKNGANFFPAR----------TCIEVSKLPLAALIEIEAVA 127
Cdd:cd06156    77 YCSELDLEDESRnesddvnpplVIVVVPELPRGALVEWQGIA 118
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 9-127 1.77e-09

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 52.08  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328   9 AAPKAIGPYSQGVITGGLIFTSGQLPLSP----HTGLLVKN-TLE---KQTLQCLENMRAILLHADADMSDV---VKTTV 77
Cdd:cd02199     8 PAPAPVGNYVPAVRTGNLLYVSGQLPRVDgklvYTGKVGADlSVEegqEAARLCALNALAALKAALGDLDRVkrvVRLTG 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2124029328  78 YLTDMMSF----AVVN---EIYNDFFIKNGAnffPARTCIEVSKLPLAALIEIEAVA 127
Cdd:cd02199    88 FVNSAPDFteqpKVANgasDLLVEVFGEAGR---HARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 24-127 3.58e-04

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 37.62  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124029328  24 GGLIFTSGQLPLSPHtGLLVKNTLEKQTLQCLENMRAIL-----LHADADMSDVVKTTVYLTDMMSFAVVNEIYNDFFIK 98
Cdd:cd06153    12 RTHLFISGTASIVGH-GTVHPGDVEAQTRETLENIEALLeaagrGGGAQFLADLLRLKVYLRDREDLPAVRAILAARLGP 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2124029328  99 NganffPARTCIEV----SKLplaaLIEIEAVA 127
Cdd:cd06153    91 A-----VPAVFLQAdvcrPDL----LVEIEAVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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