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Conserved domains on  [gi|2154099325|ref|WP_229303073|]
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MULTISPECIES: metal ABC transporter permease [Mycobacterium]

Protein Classification

metal ABC transporter permease( domain architecture ID 11437853)

metal ABC transporter permease is the transmembrane subunit (TM) of a Periplasmic Binding Protein (PBP)-dependent ABC transporter complex that facilitates the ABC transport of specific metal ions such as manganese or zinc

Gene Ontology:  GO:0055085|GO:0140359|GO:0042626|GO:0016020
PubMed:  31571164|27273632|26517919|18535149|17723295|25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnuB COG1108
ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and ...
 2-130 5.18e-20

ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440725  Cd Length: 260  Bit Score: 82.02  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   2 VCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVA 81
Cdd:COG1108   132 LAAVVLLLLLLFYRELLLVSFDPELARASGLPVRLLHLLLLVLLALTVVAALQAVGALLVSALLIIPAATARLLTRSLRR 211

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2154099325  82 AIATSVVFAEVSAVGGILLSLAPGVPVSVFVATISFVIYLICWLLRRRR 130
Cdd:COG1108   212 MLLLAVLIGVLSSVLGLYLSYYLDLPTGPTIVLVAGLLFLLSLLFSPRR 260
 
Name Accession Description Interval E-value
ZnuB COG1108
ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and ...
 2-130 5.18e-20

ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440725  Cd Length: 260  Bit Score: 82.02  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   2 VCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVA 81
Cdd:COG1108   132 LAAVVLLLLLLFYRELLLVSFDPELARASGLPVRLLHLLLLVLLALTVVAALQAVGALLVSALLIIPAATARLLTRSLRR 211

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2154099325  82 AIATSVVFAEVSAVGGILLSLAPGVPVSVFVATISFVIYLICWLLRRRR 130
Cdd:COG1108   212 MLLLAVLIGVLSSVLGLYLSYYLDLPTGPTIVLVAGLLFLLSLLFSPRR 260
ABC-3 pfam00950
ABC 3 transport family;
4-123 1.60e-08

ABC 3 transport family;


Pssm-ID: 334323  Cd Length: 258  Bit Score: 51.08  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   4 LLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAI 83
Cdd:pfam00950 135 AVILILLLLFWKELLLITFDPDHAKVIGLPVQFLYLLLLALIALTIVVALQAVGAILVIALLIIPAATARRLTRSFDSML 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2154099325  84 ATSVVFAEVSAVGGILLSL---APGVPVSVFVATISFVIYLIC 123
Cdd:pfam00950 215 IIAILIGMVSCVAGLYLSYyfdTSTGPVIVLIATLLFLISLAF 257
znuB PRK09543
zinc ABC transporter permease subunit ZnuB;
4-123 2.01e-03

zinc ABC transporter permease subunit ZnuB;


Pssm-ID: 181938  Cd Length: 261  Bit Score: 36.59  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   4 LLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAI 83
Cdd:PRK09543  135 VIVLAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTIGVAMKFVGALIITSLLIIPAATARRFARTPEQMA 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2154099325  84 ATSVVFAEVSAVGGILLSL---APGVPVSVFVATISFVIYLIC 123
Cdd:PRK09543  215 GVAVLVGMLAVTGGLTFSAfydTPAGPSVVLCAALLFILSMMK 257
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 2-123 4.92e-03

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 35.23  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   2 VCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVmSLLITPAAAAARVVVAPVA 81
Cdd:cd06550   137 ILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILF-VGLIAPHLARRLFGRSHRY 215

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2154099325  82 AIATSVVFAEVSAVGGILLS---LAPGVPVSVFVATISFVIYLIC 123
Cdd:cd06550   216 LLPLSALLGAILLLLGDLLSrtlLPSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
ZnuB COG1108
ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and ...
 2-130 5.18e-20

ABC-type Mn2+/Zn2+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440725  Cd Length: 260  Bit Score: 82.02  E-value: 5.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   2 VCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVA 81
Cdd:COG1108   132 LAAVVLLLLLLFYRELLLVSFDPELARASGLPVRLLHLLLLVLLALTVVAALQAVGALLVSALLIIPAATARLLTRSLRR 211

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2154099325  82 AIATSVVFAEVSAVGGILLSLAPGVPVSVFVATISFVIYLICWLLRRRR 130
Cdd:COG1108   212 MLLLAVLIGVLSSVLGLYLSYYLDLPTGPTIVLVAGLLFLLSLLFSPRR 260
ABC-3 pfam00950
ABC 3 transport family;
4-123 1.60e-08

ABC 3 transport family;


Pssm-ID: 334323  Cd Length: 258  Bit Score: 51.08  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   4 LLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAI 83
Cdd:pfam00950 135 AVILILLLLFWKELLLITFDPDHAKVIGLPVQFLYLLLLALIALTIVVALQAVGAILVIALLIIPAATARRLTRSFDSML 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2154099325  84 ATSVVFAEVSAVGGILLSL---APGVPVSVFVATISFVIYLIC 123
Cdd:pfam00950 215 IIAILIGMVSCVAGLYLSYyfdTSTGPVIVLIATLLFLISLAF 257
znuB PRK09543
zinc ABC transporter permease subunit ZnuB;
4-123 2.01e-03

zinc ABC transporter permease subunit ZnuB;


Pssm-ID: 181938  Cd Length: 261  Bit Score: 36.59  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   4 LLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAI 83
Cdd:PRK09543  135 VIVLAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTIGVAMKFVGALIITSLLIIPAATARRFARTPEQMA 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2154099325  84 ATSVVFAEVSAVGGILLSL---APGVPVSVFVATISFVIYLIC 123
Cdd:PRK09543  215 GVAVLVGMLAVTGGLTFSAfydTPAGPSVVLCAALLFILSMMK 257
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 2-123 4.92e-03

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 35.23  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154099325   2 VCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVmSLLITPAAAAARVVVAPVA 81
Cdd:cd06550   137 ILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILF-VGLIAPHLARRLFGRSHRY 215

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2154099325  82 AIATSVVFAEVSAVGGILLS---LAPGVPVSVFVATISFVIYLIC 123
Cdd:cd06550   216 LLPLSALLGAILLLLGDLLSrtlLPSELPVGPVTALLGAPYFLYL 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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