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Conserved domains on  [gi|2166101105|ref|WP_232089376|]
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LPXTG cell wall anchor domain-containing protein [Enterococcus malodoratus]

Protein Classification

LPXTG cell wall anchor domain-containing protein( domain architecture ID 10465180)

LPXTG cell wall anchor domain-containing protein similar to Streptococcus pyogenes IgA receptor and M protein, serotype 49

Gene Ontology:  GO:0005576

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
10-50 4.97e-06

LPXTG cell wall anchor motif;


:

Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 38.29  E-value: 4.97e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2166101105 10 VNKQKGSLPSTGGSGIYLMMAAGVAVMAIVGVAYLRSQRKE 50
Cdd:pfam00746  2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKE 42
 
Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
10-50 4.97e-06

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 38.29  E-value: 4.97e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2166101105 10 VNKQKGSLPSTGGSGIYLMMAAGVAVMAIVGVAYLRSQRKE 50
Cdd:pfam00746  2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKE 42
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 1-45 8.99e-06

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 40.12  E-value: 8.99e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2166101105   1 MATGTAETVVNKQKGS------LPSTGGSGIYLMMAAGVAVMAIVGVAYLR 45
Cdd:NF033902  481 TTADVKNTVVNNKKTVpnwffnLPLTGGAGVIILAAAGAALLGAGAFVALR 531
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 16-49 1.60e-03

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 31.68  E-value: 1.60e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 2166101105 16 SLPSTGGSGIYLMMAAGVAVMAIVGVAYLRSQRK 49
Cdd:TIGR01167  1 KLPKTGESGNSLLLLLGLLLLGLGGLLLRKRKKK 34
 
Name Accession Description Interval E-value
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
10-50 4.97e-06

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 38.29  E-value: 4.97e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2166101105 10 VNKQKGSLPSTGGSGIYLMMAAGVAVMAIVGVAYLRSQRKE 50
Cdd:pfam00746  2 KKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKE 42
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 1-45 8.99e-06

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 40.12  E-value: 8.99e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2166101105   1 MATGTAETVVNKQKGS------LPSTGGSGIYLMMAAGVAVMAIVGVAYLR 45
Cdd:NF033902  481 TTADVKNTVVNNKKTVpnwffnLPLTGGAGVIILAAAGAALLGAGAFVALR 531
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 16-49 1.60e-03

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 31.68  E-value: 1.60e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 2166101105 16 SLPSTGGSGIYLMMAAGVAVMAIVGVAYLRSQRK 49
Cdd:TIGR01167  1 KLPKTGESGNSLLLLLGLLLLGLGGLLLRKRKKK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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