|
Name |
Accession |
Description |
Interval |
E-value |
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
19-458 |
3.54e-58 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 199.63 E-value: 3.54e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 19 AIILALLFLYTFRIYKRHYLKLWAWSWLAFSMYMLTSGLHLYSTWIYSIYNPIRISLSAITISFAYIEASLLLIGTWELV 98
Cdd:COG4251 50 LLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 99 KNRKFASAHLRLILIISILLAIASSVLFIDNSQISENRFFIRVGLRSLIMGAAFFITGIWMITNLSHDKSLGKRLLIIAF 178
Cdd:COG4251 130 LLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLEL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 179 IIYGSEQFNYFLVGFLPIINVHIKFPYIQYLGLLDFFLEALIGMGMAIWL--------LENERKELERANDDLDHFFYST 250
Cdd:COG4251 210 LLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLeleeleeeLEERTAELERSNEELEQFAYVA 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPLASITGLVTLGKVHIK---DEYALEFFEKIEGRVDKLDSVIDDIISYAKSAKYQLKIEPLNFKEIVKEIETNL 327
Cdd:COG4251 290 SHDLREPLRKISGFSQLLEEDYGdklDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDL 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 328 EFNKGATHIDFICETNEEFFlSDKIKITTILHNLITNSIKYHDfHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQK 407
Cdd:COG4251 370 EPRIEERGAEIEVGPLPTVR-GDPTLLRQVFQNLISNAIKYSR-PGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEK 447
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2175629384 408 IFDMFYRASGDSV--GSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:COG4251 448 IFEIFQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
137-458 |
1.07e-56 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 190.50 E-value: 1.07e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 137 FFIRVGLRSLIMGAAFFITGIWMITNLSHDKSLGKRLLIIAFIIYGSEQFNYFLVGFLPIINVHIKFPYIQYLGLLDFFL 216
Cdd:COG0642 4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 217 EALIGMGMAIWLLENERKELERANDDLDHFFYSTSHDLRSPLASITGLVTLGKVHIKDEYAlEFFEKIEGRVDKLDSVID 296
Cdd:COG0642 84 LLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR-EYLETILRSADRLLRLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 297 DIISYAK--SAKYQLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEE--FFLSDKIKITTILHNLITNSIKYHDfh 372
Cdd:COG0642 163 DLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlpTVRGDPDRLRQVLLNLLSNAIKYTP-- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 373 kSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV--GSGLGLYIVKEAAIKLNGKVSVHSTYGKGS 450
Cdd:COG0642 241 -EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRggGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*...
gi 2175629384 451 CFKVSLPA 458
Cdd:COG0642 320 TFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
229-458 |
7.26e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 182.80 E-value: 7.26e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 229 LENERKELERANDDLDHFFYSTSHDLRSPLASITGLVTL--GKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK--S 304
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELllDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRleS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 305 AKYQLKIEPLNFKEIVKEI--ETNLEFNKGATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYHDfhkSNPYIKVSL 382
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAveELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSP---PGGTITISA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2175629384 383 VKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV--GSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:COG2205 159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGegGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
77-458 |
1.30e-51 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 178.98 E-value: 1.30e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 77 AITISFAYIEASLLLIGTWELVKNRKFASAHLRLILIISILLAIASSVLFIDNSQISENRFFIRVGLRSLIMGAAFFITG 156
Cdd:COG5002 1 LLLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 157 IWMITNLSHDKSLGKRLLIIAFIIYGSEQFNYFLVGFLPIINVHIKFPYIQYLGLLDFFleALIGMGMAIWLLENERKEL 236
Cdd:COG5002 81 LALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLS--ALLLGLLLLAAVERDITEL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 237 ERANDDLDHFFYSTSHDLRSPLASITGLV--TLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK--SAKYQLKIE 312
Cdd:COG5002 159 ERLEQMRREFVANVSHELRTPLTSIRGYLelLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRleSGELKLEKE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 313 PLNFKEIVKEIETNLEFNKGATHIDFICETNEE--FFLSDKIKITTILHNLITNSIKYHDfhkSNPYIKVSLVKDQGRVY 390
Cdd:COG5002 239 PVDLAELLEEVVEELRPLAEEKGIELELDLPEDplLVLGDPDRLEQVLTNLLDNAIKYTP---EGGTITVSLREEDDQVR 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2175629384 391 ITVEDNGRGIKPENHQKIFDMFYRA----SGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:COG5002 316 ISVRDTGIGIPEEDLPRIFERFYRVdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
251-460 |
1.62e-33 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 130.85 E-value: 1.62e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPLASITGLV------TLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKSAKYQLkiEPLNFKEIVKEIE 324
Cdd:COG5000 209 AHEIKNPLTPIQLSAerlrrkLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQL--EPVDLNELLREVL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 325 TNLEFNKGATHIDFICETNEE--FFLSDKIKITTILHNLITNSIkyhDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKP 402
Cdd:COG5000 287 ALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNAI---EAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPE 363
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 403 ENHQKIFDMFY--RASGdsvgSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPALA 460
Cdd:COG5000 364 EVLERIFEPFFttKPKG----TGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
124-458 |
2.67e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 126.07 E-value: 2.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 124 VLFIDNSQISENRFFIRVGLRSLIMGAAFFITGIWMITNLSHDKSLGKRLLIIAFIIYGSEQFNYFLVGFLPIINVHIKF 203
Cdd:COG4191 13 ALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 204 PYIQYLGLLDFFL-EALIGMGMAIWLLENERKELERANDDLDHffyST------------SHDLRSPLASITGLVTLGK- 269
Cdd:COG4191 93 LLLLLLAALDAEEnAELEELERDITELERAEEELRELQEQLVQ---SEklaalgelaagiAHEINNPLAAILGNAELLRr 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 270 ---VHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKSAKYQLkiEPLNFKEIVKEIETNLEFNKGATHIDFICETNEE- 345
Cdd:COG4191 170 rleDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER--EPVDLNELIDEALELLRPRLKARGIEVELDLPPDl 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 346 -FFLSDKIKITTILHNLITNSIkyhdfH----KSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFY--RASGD 418
Cdd:COG4191 248 pPVLGDPGQLEQVLLNLLINAI-----DameeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttKPVGK 322
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2175629384 419 svGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:COG4191 323 --GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
350-457 |
1.87e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.20 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHdfhKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV---GSGLGL 426
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 2175629384 427 YIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
350-457 |
7.96e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.99 E-value: 7.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHDFHKSnpyIKVSlVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV-GSGLGLYI 428
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGE---ITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 2175629384 429 VKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
354-456 |
2.43e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 102.30 E-value: 2.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 354 ITTILHNLITNSIKYHDFHKSnpyIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRA--SGDSVGSGLGLYIVKE 431
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGT---IEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGdkSREGGGTGLGLAIVRR 77
|
90 100
....*....|....*....|....*
gi 2175629384 432 AAIKLNGKVSVHSTYGKGSCFKVSL 456
Cdd:cd00075 78 IVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
252-458 |
4.63e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 105.70 E-value: 4.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 252 HDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKSAKYQLkiEPLNFKEIVKEIETNL--EF 329
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPER--EPVNLHEVLERVLELLraEA 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 330 NKgatHIDFICETNEE--FFLSDKIKITTILHNLITNSIK------------YHDFHKSNPYIKVSLVkdqgrVYITVED 395
Cdd:COG3852 222 PK---NIRIVRDYDPSlpEVLGDPDQLIQVLLNLVRNAAEampeggtitirtRVERQVTLGGLRPRLY-----VRIEVID 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2175629384 396 NGRGIKPENHQKIFDMFYraSGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:COG3852 294 NGPGIPEEILDRIFEPFF--TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
219-458 |
9.28e-23 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 101.56 E-value: 9.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 219 LIGMGMAIwlleNERKE----LERANDDLDHFFYSTSHDLRSPLASITGLV-TLGKVHIKDEyALEFFEKIEGRVDKLDS 293
Cdd:PRK11091 259 LMGFGRDI----TERKRyqdaLEKASRDKTTFISTISHELRTPLNGIVGLSrILLDTELTAE-QRKYLKTIHVSAITLGN 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 294 VIDDIISYAKSAKYQLKI--EPLNFKEIVKEIEtNLEF----NKGathIDFICETNE---EFFLSDKIKITTILHNLITN 364
Cdd:PRK11091 334 IFNDIIDMDKMERRKLQLdnQPIDFTDFLADLE-NLSGlqaeQKG---LRFDLEPLLplpHKVITDGTRLRQILWNLISN 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 365 SIKYHdfHKSNpyIKVSLVKDQG-RVYITVEDNGRGIKPENHQKIFDMFYRASGD-----SVGSGLGLYIVKEAAIKLNG 438
Cdd:PRK11091 410 AVKFT--QQGG--VTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpATGTGIGLAVSKRLAQAMGG 485
|
250 260
....*....|....*....|
gi 2175629384 439 KVSVHSTYGKGSCFKVSLPA 458
Cdd:PRK11091 486 DITVTSEEGKGSCFTLTIHA 505
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
357-457 |
2.32e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 86.01 E-value: 2.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHDfhKSNPYIKVSLVK---DQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV----GSGLGLYIV 429
Cdd:cd16922 4 ILLNLLGNAIKFTE--EGEVTLRVSLEEeeeDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTrkygGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 2175629384 430 KEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
252-457 |
3.03e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 93.49 E-value: 3.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 252 HDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKSAkyQLKIEPLNFKEIVKEIETNLEFNK 331
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR--ESQWQPVSLNALVEEVLQLFQTAG 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 332 GATHIDFICETNEEF--FLSDKIKITTILHNLITNSIKYHDfHKSNPYIKVSLVKDqGRVYITVEDNGRGIKPENHQKIF 409
Cdd:PRK11360 477 VQARVDFETELDNELppIWADPELLKQVLLNILINAVQAIS-ARGKIRIRTWQYSD-GQVAVSIEDNGCGIDPELLKKIF 554
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2175629384 410 DMFY--RASgdsvGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK11360 555 DPFFttKAK----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
229-457 |
1.05e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 90.68 E-value: 1.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 229 LENERKELERANDDLdhffYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDD------IISYA 302
Cdd:COG3290 179 LEEELEGVKELAEAL----RAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNpvlaalLLGKA 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 303 KSAKyQLKIEplnfkeivkeietnlefnkgathIDFICETNEEFFLSDKIKITTILHNLITNSIKY-HDFHKSNPYIKVS 381
Cdd:COG3290 255 ARAR-ERGID-----------------------LTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAvEKLPEEERRVELS 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2175629384 382 LVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRaSGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:COG3290 311 IRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
229-457 |
2.17e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.24 E-value: 2.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 229 LENERKELERANDDLDHFFYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDII--SYAKSAK 306
Cdd:PRK15347 384 LAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLdfSRIESGQ 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 307 YQLKIEPLNFKEIVKEIETNLE---FNKGATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYHDfhksNPYIKVSLV 383
Cdd:PRK15347 464 MTLSLEETALLPLLDQAMLTIQgpaQSKSLTLRTFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTE----TGGIRLRVK 539
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2175629384 384 KDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
233-457 |
1.44e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 88.81 E-value: 1.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 233 RKELERANDDLDHFFYSTSHDLRSPLASITGLVTLgkvhIKDEYAL----EFFEKIEGRVDKLDSVIDDIISY----AKS 304
Cdd:PRK11466 434 RAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQL----LADNPALnaqrDDLRAITDSGESLLTILNDILDYsaieAGG 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 305 AKYQLKIEPLNFKEIvkeIETNLEFNKGATH---IDFICETNEEF---FLSDKIKITTILHNLITNSIKYHDfhksNPYI 378
Cdd:PRK11466 510 KNVSVSDEPFEPRPL---LESTLQLMSGRVKgrpIRLATDIADDLptaLMGDPRRIRQVITNLLSNALRFTD----EGSI 582
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175629384 379 KVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK11466 583 VLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
251-457 |
3.77e-18 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 86.50 E-value: 3.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPLASITgLVT--LGKvhiKDEYaleFFEKIEGRVDKLDSVIDDIISYAKSAKyQLKIEPLNFKEIVKEI---ET 325
Cdd:PRK09467 237 SHDLRTPLTRIR-LATemMSE---EDGY---LAESINKDIEECNAIIEQFIDYLRTGQ-EMPMEMADLNALLGEViaaES 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 326 N------LEFNKGATHIDFicetneefflsDKIKITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRG 399
Cdd:PRK09467 309 GyereieTALQPGPIEVPM-----------NPIAIKRALANLVVNAARY-----GNGWIKVSSGTEGKRAWFQVEDDGPG 372
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2175629384 400 IKPENHQKIFDMFYRasGD----SVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK09467 373 IPPEQLKHLFQPFTR--GDsargSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
232-457 |
8.67e-18 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 85.41 E-value: 8.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 232 ERKELE---RANDDLD---HFFYSTSHDLRSPLASITGLVTLGKVHIKDEYAlEFFEKIEGRVDKLDSVIDDIISYAKSA 305
Cdd:COG5809 253 ERKKLEellRKSEKLSvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK-TYLDIMLSELDRIESIISEFLVLAKPQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 306 KyqLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEEF--FLSDKIKITTILHNLITNSIKyhdFHKSNPYIKVSL- 382
Cdd:COG5809 332 A--IKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIpdILGDENQLKQVFINLLKNAIE---AMPEGGNITIETk 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175629384 383 VKDQGRVYITVEDNGRGIKPENHQKIFDMFYraSGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:COG5809 407 AEDDDKVVISVTDEGCGIPEERLKKLGEPFY--TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
1.07e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 78.14 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHDfHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV--GSGLGLYIVKEAAI 434
Cdd:cd16921 4 VLTNLLGNAIKFRR-PRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEyeGTGVGLAIVRKIIE 82
|
90 100
....*....|....*....|...
gi 2175629384 435 KLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16921 83 RHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
204-457 |
1.13e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 85.04 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 204 PYIQYLG---LLDFFLEALIGMGMA----IWL---------LEN-----------ERKELERAN-------------DDL 243
Cdd:PRK10604 126 PYLYYLHqmrLLDIALLALIGLSLAfpvfLWMrphwqdmlkLEAaaqrlgdghlaERIHFDEGSslerlgvafnqmaDNI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 244 DHFFYS-------TSHDLRSPLASItglvtlgkvhikdEYALEFFEK--------IEGRVDKLDSVIDDIISYAKSAKYQ 308
Cdd:PRK10604 206 NALIASkkqlidgIAHELRTPLVRL-------------RYRLEMSDNlsaaesqaLNRDIGQLEALIEELLTYARLDRPQ 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 309 --LKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQ 386
Cdd:PRK10604 273 neLHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY-----AHSRVRVSLLLDG 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175629384 387 GRVYITVEDNGRGIKPENHQKIFDMFYR--ASGD--SVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK10604 348 NQACLIVEDDGPGIPPEERERVFEPFVRldPSRDraTGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
252-457 |
2.29e-16 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 81.32 E-value: 2.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 252 HDLRSPLASITGLVTLGKVHIKDEYalEFFEKIEGRVDKLDSVIDDIISYAKSAKYQlkIEPLNFKEIVKEIETNLEFNK 331
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKE--EYFDIMLSELDRIESIISEFLALAKPQAVN--KEKENINELIQDVVTLLETEA 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 332 GATHIDFICETNEE--FFLSDKIKITTILHNLITNSIkyhDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIF 409
Cdd:COG5805 372 ILHNIQIRLELLDEdpFIYCDENQIKQVFINLIKNAI---EAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLG 448
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2175629384 410 DMFYraSGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:COG5805 449 EPFF--TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
229-460 |
2.38e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 81.04 E-value: 2.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 229 LENERKELErANDDLDHFFYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK--SAK 306
Cdd:PRK11100 243 LESMRVKLE-GKAYVEQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARleQRQ 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 307 YQLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNE-----EFFLsdkikITTILHNLITNSIkyhDFHKSNPYIKVS 381
Cdd:PRK11100 322 ELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDarvlgDPFL-----LRQALGNLLDNAI---DFSPEGGTITLS 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 382 LVKDQGRVYITVEDNGRGIkPENHQ-KIFDMFY---RASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK11100 394 AEVDGEQVALSVEDQGPGI-PDYALpRIFERFYslpRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
...
gi 2175629384 458 ALA 460
Cdd:PRK11100 473 RHF 475
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
350-457 |
3.48e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 74.07 E-value: 3.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKyhdFHKSNPYIKVSLVK-DQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV----GSGL 424
Cdd:cd16925 1 DAEKYERVVLNLLSNAFK---FTPDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGL 77
|
90 100 110
....*....|....*....|....*....|...
gi 2175629384 425 GLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16925 78 GLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
4.90e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 73.86 E-value: 4.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHdfhKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFY-----RASGDSvgSGLGLYIVKE 431
Cdd:cd16948 9 IIGQIVSNALKYS---KQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNFQES--TGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 2175629384 432 AAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
228-457 |
1.11e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 79.06 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 228 LLENE--RKELERAnddLDHFFYSTSHDLRSPLASITGLVT-LGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKS 304
Cdd:PRK10364 223 LLQDEmkRKEKLVA---LGHLAAGVAHEIRNPLSSIKGLAKyFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKP 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 305 AkyQLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEEFFL--SDKIKITTILHNLITNSIKYHDFHKSnpyIKVSL 382
Cdd:PRK10364 300 T--HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEiqADPDRLTQVLLNLYLNAIQAIGQHGV---ISVTA 374
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175629384 383 VKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDsvGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK10364 375 SESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE--GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-456 |
2.03e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.55 E-value: 2.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHDFHKsnpYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSV----GSGLGLYIVKEA 432
Cdd:cd16947 24 ILKNLISNAIKYGSDGK---FLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRL 100
|
90 100
....*....|....*....|....
gi 2175629384 433 AIKLNGKVSVHSTYGKGSCFKVSL 456
Cdd:cd16947 101 AESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
248-457 |
2.41e-15 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 78.05 E-value: 2.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 248 YSTSHDLRSPLASI---TGLVT--LGkvhikdEYAlEFfEKIEGRVDKLDSVIDDIISYAKS-AKYQLKIEPLNFKEIVK 321
Cdd:PRK09470 248 SDISHELRTPLTRLqlaTALLRrrQG------ESK-EL-ERIETEAQRLDSMINDLLVLSRNqQKNHLERETFKANSLWS 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 322 EIETNLEFNKGATHIDFICETN-EEFFLS-DKIKITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRG 399
Cdd:PRK09470 320 EVLEDAKFEAEQMGKSLTVSAPpGPWPINgNPNALASALENIVRNALRY-----SHTKIEVAFSVDKDGLTITVDDDGPG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2175629384 400 IKPENHQKIFDMFYRASGD----SVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK09470 395 VPEEEREQIFRPFYRVDEArdreSGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
3.12e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 71.33 E-value: 3.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 354 ITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYR--ASGDSVGSGLGLYIVKE 431
Cdd:cd16950 1 LKRVLSNLVDNALRY-----GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRgdNARGTSGTGLGLAIVQR 75
|
90 100
....*....|....*....|....*.
gi 2175629384 432 AAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16950 76 ISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
252-457 |
2.02e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.60 E-value: 2.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 252 HDLRSPL--ASItGLVTLGKVHIKDEYALE------FFEKIEGRVDKLDSVIDDIISYAKSAKYQLKIEP--LNFKEIVK 321
Cdd:PRK09303 160 HDLRTPLtaASL-ALETLELGQIDEDTELKpalieqLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPqkLDLGSLCQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 322 EIEtnLEFnkgathidficetnEEFFLSDKIKITT------------------ILHNLITNSIKYhdfhkSNPYIKVSLV 383
Cdd:PRK09303 239 EVI--LEL--------------EKRWLAKSLEIQTdipsdlpsvyadqerirqVLLNLLDNAIKY-----TPEGGTITLS 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 384 ----KDQgRVYITVEDNGRGIKPENHQKIFDMFYRASGDS--VGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK09303 298 mlhrTTQ-KVQVSICDTGPGIPEEEQERIFEDRVRLPRDEgtEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-458 |
3.70e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 68.23 E-value: 3.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 358 LHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYR--ASGD--SVGSGLGLYIVKEAA 433
Cdd:cd16939 5 LDNLLRNALRY-----AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDraTGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 2175629384 434 IKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
226-457 |
8.98e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.00 E-value: 8.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 226 IWLLENERKELERANDDLDHFFYSTSHDLRSPLASITGLVTL-GKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK- 303
Cdd:PRK09959 695 IHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELlSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKi 774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 304 -SAKYQLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETN--EEFFLS-DKIKITTILHNLITNSIKYHDfhKSNPYIK 379
Cdd:PRK09959 775 eSGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpDHYLVKiDPQAFKQVLSNLLSNALKFTT--EGAVKIT 852
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 380 VSLVK---DQGRVYITVEDNGRGIKPENHQKIFDMFYRASG--DSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKV 454
Cdd:PRK09959 853 TSLGHiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTI 932
|
...
gi 2175629384 455 SLP 457
Cdd:PRK09959 933 TIP 935
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
1.14e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 67.06 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 354 ITTILHNLITNSIKYHDfHKSNPYIKVSLVKDQgrVYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEAA 433
Cdd:cd16943 4 LNQVLLNLLVNAAQAME-GRGRITIRTWAHVDQ--VLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....
gi 2175629384 434 IKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
258-458 |
1.47e-13 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 72.63 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 258 LASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLdSVIDDIISYAKSakyqlkIEPLNFKEIVKEIETNLEFNKGATHID 337
Cdd:COG3920 310 LQVVSSLLRLQARRADDPEAREALEESQNRIQAL-ALVHELLYQSED------WEGVDLRDYLRELLEPLRDSYGGRGIR 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 338 FICETnEEFFLSDKIKITT--ILHNLITNSIKYHDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPEnhqkiFDMfyra 415
Cdd:COG3920 383 IELDG-PDVELPADAAVPLglILNELVTNALKHAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDP---- 452
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2175629384 416 sgdSVGSGLGLYIVKEAAIKLNGKVSVHStyGKGSCFKVSLPA 458
Cdd:COG3920 453 ---PARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPL 490
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-458 |
1.65e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 66.58 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 358 LHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRA----SGDSVGSGLGLYIVkEAA 433
Cdd:cd16949 5 LENVLRNALRY-----SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdsarDRESGGTGLGLAIA-ERA 78
|
90 100
....*....|....*....|....*.
gi 2175629384 434 IKLN-GKVSVHSTYGKGSCFKVSLPA 458
Cdd:cd16949 79 IEQHgGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
237-457 |
3.25e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 71.93 E-value: 3.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 237 ERANDDLDHFFYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAKSAKYQLKIEPLNF 316
Cdd:PRK10841 441 EQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREF 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 317 --KEIVKEIETN---LEFNKGATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYHDfhksNPYIKVSLVKDQGRVYI 391
Cdd:PRK10841 521 spREVINHITANylpLVVKKRLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTD----TGCIVLHVRVDGDYLSF 596
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2175629384 392 TVEDNGRGIKPENHQKIFDMFYRAsGDSV-----GSGLGLYIVkEAAIKL-NGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK10841 597 RVRDTGVGIPAKEVVRLFDPFFQV-GTGVqrnfqGTGLGLAIC-EKLINMmDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
355-457 |
3.48e-13 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 71.48 E-value: 3.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 355 TTILHNLITNSIKYHDfHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDsvGSGLGLYIVKEAAI 434
Cdd:PRK11086 435 ITILGNLIENALEAVG-GEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGS--NRGVGLYLVKQSVE 511
|
90 100
....*....|....*....|...
gi 2175629384 435 KLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK11086 512 NLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
229-457 |
5.12e-13 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 71.22 E-value: 5.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 229 LENERKELERAnddldhFFYSTSHDLRSPLASITG--------LVTLGKVHIKDeyALEFFEKIEGRVDKLDSVIDdiIS 300
Cdd:PRK10490 656 LASEREQLRNA------LLAALSHDLRTPLTVLFGqaeiltldLASEGSPHARQ--ASEIRQQVLNTTRLVNNLLD--MA 725
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 301 YAKSAKYQLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYHDfHKSNPYIKV 380
Cdd:PRK10490 726 RIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAG-AQAEIGIDA 804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 381 SLVKDQgrVYITVEDNGRGIKPENHQKIFDMFYRASGDSV--GSGLGLYIVKeAAIKLN-GKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK10490 805 HVEGER--LQLDVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICR-AIVEVHgGTIWAENRPEGGACFRVTLP 881
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
251-457 |
1.42e-12 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 69.28 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPLASITGLVTLgkvhIKD---EYALEFFEKIEGRVDKLDSVIDDI----------ISYAKSakyQLKIEPL--- 314
Cdd:PRK10549 248 SHELRTPLAVLRGELEA----IQDgvrKFTPESVASLQAEVGTLTKLVDDLhqlslsdegaLAYRKT---PVDLVPLlev 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 315 ---NFKEIV--KEIETNLEFNKGAThidficetneefFLSDKIKITTILHNLITNSIKYHDfhkSNPYIKVSLVKDQGRV 389
Cdd:PRK10549 321 aggAFRERFasRGLTLQLSLPDSAT------------VFGDPDRLMQLFNNLLENSLRYTD---SGGSLHISAEQRDKTL 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2175629384 390 YITVEDNGRGIKPENHQKIFDMFYRASGD----SVGSGLGLYIVKEAAIKLNGKVSV-HSTYGkGSCFKVSLP 457
Cdd:PRK10549 386 RLTFADSAPGVSDEQLQKLFERFYRTEGSrnraSGGSGLGLAICLNIVEAHNGRIIAaHSPFG-GVSITVELP 457
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
1.50e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 63.56 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHDfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRA--SGDSVGSGLGLYIVKEAAI 434
Cdd:cd16923 4 VFSNLLSNAIKYSP---ENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGdnSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 2175629384 435 KLNGKVSVHSTyGKGSCFKVSLP 457
Cdd:cd16923 81 LHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-457 |
1.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 63.76 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 360 NLITNSIKYHdfhKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRA----SGDSVGSGLGLYIVKEAAIK 435
Cdd:cd16952 7 NLVSNAVKYT---PPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVdierCRNTGGTGLGLAIVKHVMSR 83
|
90 100
....*....|....*....|..
gi 2175629384 436 LNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16952 84 HDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-457 |
2.05e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.46 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 356 TILHNLITNSIK-YHDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSvGSGLGLYIVKEAAI 434
Cdd:cd16915 3 TIVGNLIDNALDaLAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 2175629384 435 KLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
232-458 |
2.32e-12 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 68.50 E-value: 2.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 232 ERKELERANDDldhFFYSTSHDLRSPLASITGlvtlgkvhikdeYaLEFFEK--IEGRV-DKLDSVIDDIISYAKSAKYQ 308
Cdd:PRK11006 196 QMHQLEGARRN---FFANVSHELRTPLTVLQG------------Y-LEMMQDqpLEGALrEKALHTMREQTQRMEGLVKQ 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 309 L----KIEP---LNFKEIV----------KEIETnleFNKGATHIDFicETNEEF-FLSDKIKITTILHNLITNSIKYhd 370
Cdd:PRK11006 260 LltlsKIEAaptIDLNEKVdvpmmlrvleREAQT---LSQGKHTITF--EVDNSLkVFGNEDQLRSAISNLVYNAVNH-- 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 371 fhksNP---YIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRA----SGDSVGSGLGLYIVKEAAIKLNGKVSVH 443
Cdd:PRK11006 333 ----TPegtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVdkarSRQTGGSGLGLAIVKHALSHHDSRLEIE 408
|
250
....*....|....*
gi 2175629384 444 STYGKGSCFKVSLPA 458
Cdd:PRK11006 409 SEVGKGTRFSFVLPE 423
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-457 |
5.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 62.48 E-value: 5.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHDfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGD----SVGSGLG 425
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTD---TGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnraSGGSGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 2175629384 426 LYIVKEAAIKLNGKVSV-HSTYGKGSCfKVSLP 457
Cdd:cd16946 78 LAICHNIALAHGGTISAeHSPLGGLRL-VLTLP 109
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
6.12e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.20 E-value: 6.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 357 ILHNLITNSIKYHDfhKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFY--RASGDSVG--SGLGLYIVKEa 432
Cdd:cd16953 4 VLRNLIGNAISFSP--PDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGqhSGLGLSISRQ- 80
|
90 100 110
....*....|....*....|....*....|
gi 2175629384 433 AIKLNGKVSVHSTYG-----KGSCFKVSLP 457
Cdd:cd16953 81 IIEAHGGISVAENHNqpgqvIGARFTVQLP 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
335-456 |
6.34e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.65 E-value: 6.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 335 HIDFICETNEEF-FLSDKIKITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFY 413
Cdd:cd16954 18 GVSISLDISPELrFPGERNDLMELLGNLLDNACKW-----CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2175629384 414 RASGDSVGSGLGLYIVKEAAIKLNGKVSV-HSTYGkGSCFKVSL 456
Cdd:cd16954 93 RLDEQRPGQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-456 |
2.92e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.78 E-value: 2.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 354 ITTILHNLITNSI-KYHDFhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEA 432
Cdd:cd16976 1 IQQVLMNLLQNALdAMGKV--ENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 2175629384 433 AIKLNGKVSVHSTYGKGSCFKVSL 456
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
4.68e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.40 E-value: 4.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHdfhKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYR--ASGDSVG-SGLGL 426
Cdd:cd16975 1 DTLLLSRALINIISNACQYA---PEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRddTSRRSGGhYGMGL 77
|
90 100
....*....|....*....|....*...
gi 2175629384 427 YIVKEAAIKLNGKVSVHSTYGKGSCFKV 454
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-456 |
5.17e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 59.73 E-value: 5.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHdfhKSNPYIKVSLVKDQGRVyITVEDNGRGIKPENHQKIFDMFYRASGDSV-GSGLGLYI 428
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYS---PQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQNYgGSGLGLSI 85
|
90 100
....*....|....*....|....*...
gi 2175629384 429 VKEAAIKLNGKVSVHSTYGKGSCFKVSL 456
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
234-451 |
7.81e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 61.24 E-value: 7.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 234 KELERANDDLDHFFY---------STSHDLRSPLASI-TGLVTLGKVHIK--DEYALEFFEKIEGRVDKLDSVIDDIISY 301
Cdd:COG4192 415 KNLRQTQDELIQAAKmavvgqtmtSLAHELNQPLNAMsMYLFSAKKALEQenYAQLPTSLDKIEGLIERMDKIIKSLRQF 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 302 AKsaKYQLKIEPLNFKEIVKE----IETNLEFNKGATHIDficetNEEFFLSDKIKITTILHNLITNSIkyhDFHKSNPY 377
Cdd:COG4192 495 SR--KSDTPLQPVDLRQVIEQawelVESRAKPQQITLHIP-----DDLMVQGDQVLLEQVLVNLLVNAL---DAVATQPQ 564
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2175629384 378 IKVSLVKDQGRVYITVEDNGRGIkpENHQKIFDMFYraSGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSC 451
Cdd:COG4192 565 ISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFT--TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAM 634
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
230-457 |
2.58e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.71 E-value: 2.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 230 ENERKELERandDLdhffystsHDlrSPLASITGL-----VTLGKVHIKDEYALEFFEKIEgrvDKLDSVIDDI--ISYA 302
Cdd:COG4585 51 EEERRRIAR---EL--------HD--GVGQSLSAIklqleAARRLLDADPEAAREELEEIR---ELAREALAELrrLVRG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 303 ksakyqLKIEPLNFKEIVKEIETNLEFNKGATHIDFICETNEEFF-LSDKIKIT--TILHNLITNSIKYhdfhkSNP-YI 378
Cdd:COG4585 115 ------LRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDrLPPEVELAlyRIVQEALTNALKH-----AGAtRV 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175629384 379 KVSLVKDQGRVYITVEDNGRGIKPEnhqkifdmfyrasgDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:COG4585 184 TVTLEVDDGELTLTVRDDGVGFDPE--------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
294-457 |
3.72e-09 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 58.92 E-value: 3.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 294 VIDDIISYakSAKYQLKIEPLNFKEIVKE------------IETNLEFNKGATHIdficetneeffLSDKIKITTILHNL 361
Cdd:PRK13837 502 IIDQILAF--GRKGERNTKPFDLSELVTEiapllrvslppgVELDFDQDQEPAVV-----------EGNPAELQQVLMNL 568
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 362 ITNSIKYHDfhkSNPYIKVSLVKDQGR---------------VYITVEDNGRGIKPENHQKIFDMFY--RASGdsvgSGL 424
Cdd:PRK13837 569 CSNAAQAMD---GAGRVDISLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFttRAGG----TGL 641
|
170 180 190
....*....|....*....|....*....|...
gi 2175629384 425 GLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK13837 642 GLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
6.32e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 53.17 E-value: 6.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 354 ITTILHNLITNSIKYHDFHKSNP---YIKVSlVKDQGRVYITVEDNGRGIKPENHQKIFDMFYraSGDSVGSGLGLYIVK 430
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERrelTIRTS-PADDRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICR 77
|
90 100
....*....|....*....|....*..
gi 2175629384 431 EAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
389-457 |
6.99e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 53.54 E-value: 6.99e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2175629384 389 VYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-442 |
2.00e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 52.08 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 358 LHNLITNSIkyhDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFY---RASGDSVGSGLGLYIVKEAAI 434
Cdd:cd16945 9 INNLLDNAI---DFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQKSTGLGLAFVQEVAQ 85
|
....*...
gi 2175629384 435 KLNGKVSV 442
Cdd:cd16945 86 LHGGRITL 93
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
350-457 |
2.04e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 56.78 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITNSIKYHDfhKSNPYIKVSLVK-DQGRVYITVE--DNGRGIkPENHQ-KIFDMFYRAsgDSV----- 420
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFTE--SGNIDILVELRAlSNTKVQLEVQirDTGIGI-SERQQsQLFQAFRQA--DASisrrh 479
|
90 100 110
....*....|....*....|....*....|....*...
gi 2175629384 421 -GSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:PRK11107 480 gGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
251-429 |
3.44e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 55.36 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPLASIT-GLVTLGKVHIKDEYALeffekIEgRVDKLDSVIDDIISYAK------SAKYQlkiePLNFKEIV--- 320
Cdd:PRK10755 145 AHELRTPLAGIRlHLELLEKQHHIDVAPL-----IA-RLDQMMHTVEQLLQLARagqsfsSGHYQ----TVKLLEDVilp 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 321 --KEIETNLEFNkgATHIDFICETNEEFFLSDKIKITTILHNLITNSIKYHDFHKSnpyIKVSLVKDQGRVYITVEDNGR 398
Cdd:PRK10755 215 sqDELSEMLEQR--QQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGST---ITIKLSQEDGGAVLAVEDEGP 289
|
170 180 190
....*....|....*....|....*....|.
gi 2175629384 399 GIKPENHQKIFDMFYRASGDSVGSGLGLYIV 429
Cdd:PRK10755 290 GIDESKCGELSKAFVRMDSRYGGIGLGLSIV 320
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
360-455 |
4.68e-08 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 55.04 E-value: 4.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 360 NLITNSIKYhdfhkSNPYIKVSLVKDQGRvyITVEDNGRGIKPENHQKIFDMFYRASGDSV-GSGLGLYIVKEAAiKLNG 438
Cdd:PRK10337 359 NLLDNAIRY-----SPQGSVVDVTLNARN--FTVRDNGPGVTPEALARIGERFYRPPGQEAtGSGLGLSIVRRIA-KLHG 430
|
90
....*....|....*...
gi 2175629384 439 -KVSVHSTYGKGSCFKVS 455
Cdd:PRK10337 431 mNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-457 |
5.46e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 51.00 E-value: 5.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 350 DKIKITTILHNLITN---SIKYHDFHKSNPYIKVSLVKDqGRVYITVEDNGRGIKPENHQKIFDMFYRASgdSVGSGLGL 426
Cdd:cd16944 1 DTTQISQVLTNILKNaaeAIEGRPSDVGEVRIRVEADQD-GRIVLIVCDNGKGFPREMRHRATEPYVTTR--PKGTGLGL 77
|
90 100 110
....*....|....*....|....*....|.
gi 2175629384 427 YIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16944 78 AIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
391-457 |
5.63e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 50.86 E-value: 5.63e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2175629384 391 ITVEDNGRGIKPENHQKIFDMFyrASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKgSCFKVSLP 457
Cdd:cd16918 46 VSVIDNGPGIPPDLQDTIFYPM--VSGRENGTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-457 |
6.52e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 50.50 E-value: 6.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 361 LITNSIKyHDF--HKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGdsvGSGLGLYIVKEAAIKLNG 438
Cdd:cd16957 9 LVENAIR-HAFpkRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK---GTGTALENLNRRLIGLFG 84
|
90 100
....*....|....*....|..
gi 2175629384 439 KVS---VHSTYGKGSCFKVSLP 457
Cdd:cd16957 85 SEAclhIESEVHGGTEVWFVIP 106
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-457 |
6.64e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 49.86 E-value: 6.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 362 ITNSIKyhdfHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKifdmfyrasgdsvGSGLGLYIVKEAAIKLNGKVS 441
Cdd:cd16917 9 LTNALK----HAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG-------------GGGFGLLGMRERAELLGGTLT 71
|
90
....*....|....*.
gi 2175629384 442 VHSTYGKGSCFKVSLP 457
Cdd:cd16917 72 IGSRPGGGTRVTARLP 87
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
378-457 |
8.26e-08 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 54.42 E-value: 8.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 378 IKVSLVKDQGRVYITVEDNGRGIKPEN-HQK-----------------------IFdmfyrASG----DSV----GSGLG 425
Cdd:COG0643 311 ITLSAYHEGGRVVIEVSDDGRGLDLEKiRAKaiekglitaeeaaalsdeellelIF-----APGfstaEEVtdlsGRGVG 385
|
90 100 110
....*....|....*....|....*....|..
gi 2175629384 426 LYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:COG0643 386 MDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-457 |
2.02e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 48.98 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 358 LHNLITNSIKYHDFHKSNP-YIKVSLVKDQGRVYITVEDNGRGIKPenhqKIFDMfyRASGDSVGSGLGLYIVKEAAIKL 436
Cdd:cd16924 6 LQPLVENAIQHGLSPLTDKgVVTISALKEDNHVMIEVEDNGRGIDP----KVLNI--LGKKPKEGNGIGLYNVHQRLILL 79
|
90 100
....*....|....*....|....
gi 2175629384 437 NGK---VSVHSTYGKGSCFKVSLP 457
Cdd:cd16924 80 FGEdygIHIASEPDKGTRITFTIP 103
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
378-457 |
2.49e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.66 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 378 IKVSLVKDQGRVYITVEDNGRGIkpeNHQKI----------------------FDMFYRASG----DSV----GSGLGLY 427
Cdd:cd16916 72 ITLRAEHQGNQVVIEVSDDGRGI---DREKIrekaierglitadeaatlsddeVLNLIFAPGfstaEQVtdvsGRGVGMD 148
|
90 100 110
....*....|....*....|....*....|
gi 2175629384 428 IVKEAAIKLNGKVSVHSTYGKGSCFKVSLP 457
Cdd:cd16916 149 VVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
251-460 |
3.79e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 52.47 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 251 SHDLRSPlasITGLVT-----LGKVHIKDEYALEFFEKIE--GRVDKLdsvIDDIISYAKSAKYQLKIE--PLNFK-EIV 320
Cdd:PRK09835 270 AHEIRTP---ITNLITqteiaLSQSRSQKELEDVLYSNLEelTRMAKM---VSDMLFLAQADNNQLIPEkkMLDLAdEVG 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 321 K----------EIETNLEFNKGATHIDficetneefflSDKIKITTILHNLITNSIKYHDFHKSnpyIKVSLVKDQGRVY 390
Cdd:PRK09835 344 KvfdffeawaeERGVELRFVGDPCQVA-----------GDPLMLRRAISNLLSNALRYTPAGEA---ITVRCQEVDHQVQ 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2175629384 391 ITVEDNGRGIKPENHQKIFDMFYRA------SGDsvGSGLGLYIVKEAAIKLNGKVSVHSTyGKGSCFKVSLPALA 460
Cdd:PRK09835 410 LVVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGE--GSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVISLPRLE 482
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
246-303 |
3.90e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.21 E-value: 3.90e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 2175629384 246 FFYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK 303
Cdd:pfam00512 5 FLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
240-303 |
4.72e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.82 E-value: 4.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175629384 240 NDDLDHFFYSTSHDLRSPLASITGLVTLGKVHI-KDEYALEFFEKIEGRVDKLDSVIDDIISYAK 303
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELlDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
353-430 |
4.79e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 48.76 E-value: 4.79e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2175629384 353 KITTILHNLITNSIKYHDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDmfyrasgDSVGSGLGLYIVK 430
Cdd:COG2172 34 DLVLAVSEAVTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-------TLAEGGRGLFLIR 104
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
243-303 |
1.21e-06 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 45.63 E-value: 1.21e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2175629384 243 LDHFFYSTSHDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLDSVIDDIISYAK 303
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
4-457 |
1.57e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.40 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 4 LSVRIFSQYLIQGVWAIILALLFLYTFRIYKRHYLKLWAWSWLAFSMYMLTSGLHLYSTWIYSIYNPIRISLSAITISFA 83
Cdd:COG2972 20 LVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 84 YIEASLLLIGTWELVKNRKFASAHLRLILIISILLAIASSVLFIDNSQISENRFFIRVGLrsLIMGAAFFITGIWMITNL 163
Cdd:COG2972 100 LLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLI--LLIILLLLLLALLLSYLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 164 ShdKSLGKRLLIIAFIIYGSEQFNYflvgflpiinVHIKFPYIQYLGLLdffLEALIGMGMAIWLLENERKELERANDDL 243
Cdd:COG2972 178 S--RSITRPIKRLKKAMKKVEKGDL----------VRLEVSGNDEIGIL---ARSFNEMVERIKELIEEVYELELEKKEA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 244 D----------HFFYSTshdlrspLASITGLVTLGKVHIKDEYAL---EFFEKIEGRVDKLDSVIDDIiSYAKSakYqLK 310
Cdd:COG2972 243 ElkalqaqinpHFLFNT-------LNSIRWLAELEDPEEAEEMLEalsKLLRYSLSKGDELVTLEEEL-ELIKS--Y-LE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 311 IEPLNFKEivkeietnlefnkgatHIDFICETNEEFflsDKIKI-TTILHNLITNSIkYHDFHKSNPY--IKVSLVKDQG 387
Cdd:COG2972 312 IQKLRFGD----------------RLEVEIEIDEEL---LDLLIpKLILQPLVENAI-EHGIEPKEGGgtIRISIRKEGD 371
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2175629384 388 RVYITVEDNGRGIKPENHQKIFDMFyraSGDSVGSGLGLYIVKEAAIKLNGK---VSVHSTYGKGSCFKVSLP 457
Cdd:COG2972 372 RLVITVEDNGVGMPEEKLEKLLEEL---SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIP 441
|
|
| PRK04184 |
PRK04184 |
DNA topoisomerase VI subunit B; Validated |
345-413 |
1.69e-05 |
|
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 47.19 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 345 EFF--------LSDKIK-ITTILHNLITNSIKYHDFHKSNPYIKVSL--VKDQGRVY-ITVEDNGRGIKPENHQKIF-DM 411
Cdd:PRK04184 19 EFFeknkellgFDNPARaLYTTVKELVDNSLDACEEAGILPDIKIEIkrVDEGKDHYrVTVEDNGPGIPPEEIPKVFgKL 98
|
..
gi 2175629384 412 FY 413
Cdd:PRK04184 99 LY 100
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
314-459 |
3.78e-05 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 46.12 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 314 LNFKEIVKEIETNLEFNKGATHIDFICETNEEFfLSDKIKITtiLHNL----ITNSIKyhdfHKSNPYIKVSLVKDQGRV 389
Cdd:PRK11644 370 LTLEQAIRSLMREMELEDRGIVSHLDWRIDESA-LSETQRVT--LFRVcqegLNNIVK----HADASAVTLQGWQQDERL 442
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 390 YITVEDNGRGIKPENHQKifdmfyrasgdsvgsGLGLYIVKEAAIKLNGKVSVHSTYgkGSCFKVSLPAL 459
Cdd:PRK11644 443 MLVIEDDGSGLPPGSGQQ---------------GFGLRGMRERVTALGGTLTISCTH--GTRLSVSLPQR 495
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
347-442 |
5.30e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.39 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 347 FLSDKIKITTILHNLITNSIKYhdfhkSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGL 426
Cdd:PRK10815 372 FVGEKNDFMEVMGNVLDNACKY-----CLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGL 446
|
90
....*....|....*.
gi 2175629384 427 YIVKEAAIKLNGKVSV 442
Cdd:PRK10815 447 SVAREITEQYEGKISA 462
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
345-413 |
6.35e-05 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 43.88 E-value: 6.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 345 EFF--------LSDKIK-ITTILHNLITNSIKYHDFHKSNPYIKVSLVK-DQGRVYITVEDNGRGIKPENHQKIF-DMFY 413
Cdd:cd16933 2 EFFrknkemlgFDNPIRsLYTTVRELVENSLDATEEAGILPDIKVEIEEiGKDHYKVIVEDNGPGIPEEQIPKVFgKVLY 81
|
|
| PRK14867 |
PRK14867 |
DNA topoisomerase VI subunit B; Provisional |
345-409 |
9.89e-05 |
|
DNA topoisomerase VI subunit B; Provisional
Pssm-ID: 237841 [Multi-domain] Cd Length: 659 Bit Score: 44.81 E-value: 9.89e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2175629384 345 EFF--------LSDKIK-ITTILHNLITNSIKYHDFHKSNPYIKVSLVKDQGRVY-ITVEDNGRGIKPENHQKIF 409
Cdd:PRK14867 19 EFFrknkhmlgYSGKLRsMTTIIHELVTNSLDACEEAEILPDIKVEIEKLGSDHYkVAVEDNGPGIPPEFVPKVF 93
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
387-458 |
2.28e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 43.51 E-value: 2.28e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2175629384 387 GR-VYITVEDNGRGIKPENHQKIFDMFYRASGDSVGSGLGLYIVKEAAIKLNGKVSVHSTYGKGSCFKVSLPA 458
Cdd:PRK13557 322 GRyVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
361-430 |
5.36e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.79 E-value: 5.36e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 361 LITNSIKYHDFHKSNPYIKVSLVKDQGRVYITVEDNGRGIKPENHQkifdmfyRASGDSVGSGLGLYIVK 430
Cdd:cd16936 8 AVTNAVRHAYRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPA-------DPDAGLREGGRGLALIR 70
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
252-457 |
7.28e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 41.97 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 252 HDLRSPLASITGLVTLGKVHIKDEYALEFFEKIEGRVDKLdsviddiiSYAKSAKYQLK-IEPLNFKEIVKEIETNLE-- 328
Cdd:PRK13560 614 HRVKNNLQIISSLLDLQAEKLHDEEAKCAFAESQDRICAM--------ALAHEKLYQSEdLADIDFLDYIESLTAHLKns 685
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 329 FNKGATHIDFICETNEEFFLSDK-IKITTILHNLITNSIKYHDFHKSNPYIKVSLVKD-QGRVYITVEDNGRGIkPENhq 406
Cdd:PRK13560 686 FAIDFGRIDCKIDADDGCLDIDKaIPCGLIISELLSNALKHAFPDGAAGNIKVEIREQgDGMVNLCVADDGIGL-PAG-- 762
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2175629384 407 kiFDmfYRASgdsvgSGLGLYIVKEAAIKLNGKVSVHSTygKGSCFKVSLP 457
Cdd:PRK13560 763 --FD--FRAA-----ETLGLQLVCALVKQLDGEIALDSR--GGARFNIRFP 802
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
335-456 |
1.12e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.10 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175629384 335 HIDFICETNEE--FFLSDkIKITTILHNLITNSIKY-HDFHKSNPYIKVSLVKDQGRVYITVEDNgrgiKPENHQKIFDM 411
Cdd:cd16935 17 GIEFTIEIDIPilLPISP-LDLCIIFGNLLDNAIEAcAKIDKENRFIHLKIRQKKGFLIISIENS----YEGELKKKNGL 91
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90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2175629384 412 FYRASGDSVGsGLGLYIVKEAAIKLNGKVsvhSTYGKGSCFKVSL 456
Cdd:cd16935 92 FLSTKKDKNH-GIGLKSIREIVKKYNGNL---SIEYENGIFTLSI 132
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