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Conserved domains on  [gi|2185807945|ref|WP_236711369|]
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MarR family winged helix-turn-helix transcriptional regulator [Novosphingobium barchaimii]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-90 4.14e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 4.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807945   2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAVAVTEPLRVELGARLLNALTPSDRRHF 81
Cdd:COG1846    53 LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEAL 132


                  ....*....
gi 2185807945  82 HAALQKLLQ 90
Cdd:COG1846   133 LRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-90 4.14e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 4.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807945   2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAVAVTEPLRVELGARLLNALTPSDRRHF 81
Cdd:COG1846    53 LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEAL 132


                  ....*....
gi 2185807945  82 HAALQKLLQ 90
Cdd:COG1846   133 LRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
6-78 1.43e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 55.29  E-value: 1.43e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2185807945    6 DVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAVAVTEPLRVELGARLLNALTPSDR 78
Cdd:smart00347  29 ELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 2-43 1.03e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.46  E-value: 1.03e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2185807945  2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVK 43
Cdd:pfam01047 18 LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 22-88 5.53e-03

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 33.82  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2185807945  22 LDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAV----AVTEPLRVElgarLLNALTPSDRRHFHAALQKL 88
Cdd:PRK03573   67 LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLIseveAVINKTRAE----ILHGISAEEIEQLITLIAKL 133
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-90 4.14e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.47  E-value: 4.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807945   2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAVAVTEPLRVELGARLLNALTPSDRRHF 81
Cdd:COG1846    53 LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEAL 132


                  ....*....
gi 2185807945  82 HAALQKLLQ 90
Cdd:COG1846   133 LRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
6-78 1.43e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 55.29  E-value: 1.43e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2185807945    6 DVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAVAVTEPLRVELGARLLNALTPSDR 78
Cdd:smart00347  29 ELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 2-43 1.03e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.46  E-value: 1.03e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 2185807945  2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVK 43
Cdd:pfam01047 18 LTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
2-53 1.17e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 40.96  E-value: 1.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2185807945   2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEdrrvkrLAITPAGEA 53
Cdd:COG1321    25 VRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGRE 70
HTH_27 pfam13463
Winged helix DNA-binding domain;
3-51 2.05e-05

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 38.81  E-value: 2.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 2185807945  3 RAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRRVKRLAITPAG 51
Cdd:pfam13463 20 TLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 2-37 1.39e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 1.39e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2185807945  2 ARAADVAEIMNLAPRTVTEALDGLEREGLIQRVPDK 37
Cdd:pfam01325 20 VKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYK 55
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 4-41 1.05e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.10  E-value: 1.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 2185807945  4 AADVAEIMNLAPRTVTEALDGLEREGLIQRVPDKEDRR 41
Cdd:pfam12802 22 VAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 5-37 3.10e-03

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 33.73  E-value: 3.10e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2185807945   5 ADVAEIMNLAPRTVTEALDGLEREGLIQRVPDK 37
Cdd:smart00529  2 SEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYR 34
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 22-88 5.53e-03

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 33.82  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2185807945  22 LDGLEREGLIQRVPDKEDRRVKRLAITPAGEAAV----AVTEPLRVElgarLLNALTPSDRRHFHAALQKL 88
Cdd:PRK03573   67 LDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLIseveAVINKTRAE----ILHGISAEEIEQLITLIAKL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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