|
Name |
Accession |
Description |
Interval |
E-value |
| DISARM_DrmD |
NF038317 |
DISARM system SNF2-like helicase DrmD, long form; DrmD, a SNF2-like helicase, is a component ... |
3-299 |
5.31e-51 |
|
DISARM system SNF2-like helicase DrmD, long form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase.
Pssm-ID: 468471 [Multi-domain] Cd Length: 1023 Bit Score: 184.67 E-value: 5.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 3 EAGERVRLKNDPAVVG-VVTDRPP-------------EERAGRT---FFQIELptGRRSLPANQLEhvlaapdalvDLRN 65
Cdd:NF038317 3 EPGQLVEVRGRQWVVSdVQLPRSPadqqhlvtlqsldDDALGEEldvIWELEP--GARVLERAGLP----------EVTE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 66 GKLSAPTDLRRALTHLR------MTGRLADMIYSMGATNTefhAYQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWT 139
Cdd:NF038317 71 GGFDDPERLAAFLDAVRwgavtsADRRLLQAPFRSGISIE---DYQLEPLVRALDMPRVNLLIADDVGLGKTIEAGLVIQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 140 ELVARnHDCRRLLVVCPKPLVEKWRAELRNKFNVDARIcgaaelLDTLRDDQERRE-GFQV---------IASLSAIRPP 209
Cdd:NF038317 148 ELLLR-HRARRVLIVCPASLQEKWRDEMREKFGLDFRI------VDSEYVAQLRRErGLHAnpwtsfprlIVSMDWLRGE 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 210 RgwddpdepasgARADLARLLNDSAQD--LFDLAIFDEAHHLRNAETMNHKLA----KLVTDVSDYS---LFLSATPINL 280
Cdd:NF038317 221 R-----------AQRLLRDVLPAHADTprAFDLLIVDEAHNVAPASPSKYAVDsqrtRLIRDLAPHFehrLFLSATPHNG 289
|
330
....*....|....*....
gi 2185807946 281 RANDLRALLKLIDPDTFER 299
Cdd:NF038317 290 YSESFTALLELLDPQRFAR 308
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
104-310 |
2.96e-48 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 163.61 E-value: 2.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNhDCRRLLVVCPKPLVEKWRAELRNKFNVDARICGAAEL 183
Cdd:cd18011 4 HQIDAVLRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLRG-DAKRVLILCPASLVEQWQDELQDKFGLPFLILDRETA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 184 LDTLRDDQERREGFQ-VIASLSAIRPPRGWDDPDEPASgaradlarllndsaqdlFDLAIFDEAHHLRNA----ETMNHK 258
Cdd:cd18011 83 AQLRRLIGNPFEEFPiVIVSLDLLKRSEERRGLLLSEE-----------------WDLVVVDEAHKLRNSgggkETKRYK 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2185807946 259 LAKLVTDVSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQEEN 310
Cdd:cd18011 146 LGRLLAKRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRLDGLR 197
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
2-303 |
1.03e-31 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 127.65 E-value: 1.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 2 FEAGERVRLKNDPAVVGVVTDRPPEERAGRTFFQIELPTGRRSLPANQLEHVLAAPDALVDLRNGKLSAPTDLRRALTHL 81
Cdd:COG0553 143 AALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAF 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 82 RMTgRLADMIYSMGAT-NTEFHAYQFKPV--LKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDcRRLLVVCPKP 158
Cdd:COG0553 223 RLR-RLREALESLPAGlKATLRPYQLEGAawLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTS 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 159 LVEKWRAELRnKFNVDARICGAAELLDTLRDDQERREGFQVIASLsairpprgwddpdepaSGARADLARLLNDSaqdlF 238
Cdd:COG0553 301 LVGNWQRELA-KFAPGLRVLVLDGTRERAKGANPFEDADLVITSY----------------GLLRRDIELLAAVD----W 359
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2185807946 239 DLAIFDEAHHLRNAETMNHKLAKLVTdvSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLF 303
Cdd:COG0553 360 DLVILDEAQHIKNPATKRAKAVRALK--ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAF 422
|
|
| DpdE |
NF041062 |
protein DpdE; |
100-300 |
2.97e-23 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 102.74 E-value: 2.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 100 EFHAYQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDcRRLLVVCPKPLVEKWRAELRNKFNVDaricg 179
Cdd:NF041062 153 ELEPHQVAVVRRVLQDPVQRYLLADEVGLGKTIEAGLVIRQHLLDNPD-ARVLVLVPDALVRQWRRELRDKFFLD----- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 180 aaelldtlrddQERREGFQVIASlsairpprgwDDPDEPASGARAdlarllndsaqdlFDLAIFDEAHHL-RNA------ 252
Cdd:NF041062 227 -----------DFPGARVRVLSH----------EEPERWEPLLDA-------------PDLLVVDEAHQLaRLAwsgdpp 272
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2185807946 253 -ETMNHKLAKLVtDVSDYSLFLSATPINLRANDLRALLKLIDPDTFERE 300
Cdd:NF041062 273 eRARYRELAALA-HAAPRLLLLSATPVLGNEETFLALLHLLDPDLYPLD 320
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
121-348 |
3.66e-13 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 71.41 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 121 LIADEVGLGKTIEAGLIWTE--LVARnhdCRRLLVVCPKPLVEKWRAELRNKFNVDARICGAAELLDTLRDDQERREGFQ 198
Cdd:PRK04914 173 LLADEVGLGKTIEAGMIIHQqlLTGR---AERVLILVPETLQHQWLVEMLRRFNLRFSLFDEERYAEAQHDADNPFETEQ 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 199 -VIASLSAIRpprgwDDPDepasgaradlarlLNDSAQDL-FDLAIFDEAHHL-------RNAETMNHKLAKLVTDVsdy 269
Cdd:PRK04914 250 lVICSLDFLR-----RNKQ-------------RLEQALAAeWDLLVVDEAHHLvwseeapSREYQVVEQLAEVIPGV--- 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2185807946 270 sLFLSATPINLRANDLRALLKLIDPDTFereYLFDILQEEnvplvrawEAArdtrvpMHELAELVGDLPEGRVLKTGER 348
Cdd:PRK04914 309 -LLLTATPEQLGQESHFARLRLLDPDRF---HDYEAFVEE--------QQQ------YRPVADAVQALLAGEKLSDDAL 369
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
96-308 |
7.49e-12 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 64.05 E-value: 7.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 96 ATNTEFHAYQFKPVLKLLNAPsRGLLIADEVGLGKTIeAGLIWTELVARNHDCRRLLVVCP-KPLVEKWRAELRNKF--- 171
Cdd:smart00487 4 FGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTL-AALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 172 -NVDARICGAAELLDTLRDDQERREGFqVIASLSAirpprgwddpdepasgaradLARLLNDSAQDL--FDLAIFDEAHH 248
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKLESGKTDI-LVTTPGR--------------------LLDLLENDKLSLsnVDLVILDEAHR 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2185807946 249 LRN---AETMNHKLAKLVTDVsdYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQE 308
Cdd:smart00487 141 LLDggfGDQLEKLLKLLPKNV--QLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
104-306 |
9.30e-12 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 65.40 E-value: 9.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPV---LKLLNAPSRGLLIADEVGLGKTIEA-GLIWTELVARNHDCRRLLVVCPKPLVEKWRAELRNKFNVDAriCG 179
Cdd:pfam00176 1 YQIEGVnwmLSLENNLGRGGILADEMGLGKTLQTiSLLLYLKHVDKNWGGPTLIVVPLSLLHNWMNEFERWVSPPA--LR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 180 AAELLDT------LRDDQERREGFQV-IASLSAIR------PPRGWDdpdepasgaradlaRLlndsaqdlfdlaIFDEA 246
Cdd:pfam00176 79 VVVLHGNkrpqerWKNDPNFLADFDVvITTYETLRkhkellKKVHWH--------------RI------------VLDEG 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2185807946 247 HHLRNAETMNHKlaKLVTDVSDYSLFLSATPINLRANDLRALLKLIDPD------TFEREYLFDIL 306
Cdd:pfam00176 133 HRLKNSKSKLSK--ALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGpfgslsTFRNWFDRPIE 196
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DISARM_DrmD |
NF038317 |
DISARM system SNF2-like helicase DrmD, long form; DrmD, a SNF2-like helicase, is a component ... |
3-299 |
5.31e-51 |
|
DISARM system SNF2-like helicase DrmD, long form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase.
Pssm-ID: 468471 [Multi-domain] Cd Length: 1023 Bit Score: 184.67 E-value: 5.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 3 EAGERVRLKNDPAVVG-VVTDRPP-------------EERAGRT---FFQIELptGRRSLPANQLEhvlaapdalvDLRN 65
Cdd:NF038317 3 EPGQLVEVRGRQWVVSdVQLPRSPadqqhlvtlqsldDDALGEEldvIWELEP--GARVLERAGLP----------EVTE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 66 GKLSAPTDLRRALTHLR------MTGRLADMIYSMGATNTefhAYQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWT 139
Cdd:NF038317 71 GGFDDPERLAAFLDAVRwgavtsADRRLLQAPFRSGISIE---DYQLEPLVRALDMPRVNLLIADDVGLGKTIEAGLVIQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 140 ELVARnHDCRRLLVVCPKPLVEKWRAELRNKFNVDARIcgaaelLDTLRDDQERRE-GFQV---------IASLSAIRPP 209
Cdd:NF038317 148 ELLLR-HRARRVLIVCPASLQEKWRDEMREKFGLDFRI------VDSEYVAQLRRErGLHAnpwtsfprlIVSMDWLRGE 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 210 RgwddpdepasgARADLARLLNDSAQD--LFDLAIFDEAHHLRNAETMNHKLA----KLVTDVSDYS---LFLSATPINL 280
Cdd:NF038317 221 R-----------AQRLLRDVLPAHADTprAFDLLIVDEAHNVAPASPSKYAVDsqrtRLIRDLAPHFehrLFLSATPHNG 289
|
330
....*....|....*....
gi 2185807946 281 RANDLRALLKLIDPDTFER 299
Cdd:NF038317 290 YSESFTALLELLDPQRFAR 308
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
104-310 |
2.96e-48 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 163.61 E-value: 2.96e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNhDCRRLLVVCPKPLVEKWRAELRNKFNVDARICGAAEL 183
Cdd:cd18011 4 HQIDAVLRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLRG-DAKRVLILCPASLVEQWQDELQDKFGLPFLILDRETA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 184 LDTLRDDQERREGFQ-VIASLSAIRPPRGWDDPDEPASgaradlarllndsaqdlFDLAIFDEAHHLRNA----ETMNHK 258
Cdd:cd18011 83 AQLRRLIGNPFEEFPiVIVSLDLLKRSEERRGLLLSEE-----------------WDLVVVDEAHKLRNSgggkETKRYK 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2185807946 259 LAKLVTDVSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQEEN 310
Cdd:cd18011 146 LGRLLAKRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRLDGLR 197
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
2-303 |
1.03e-31 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 127.65 E-value: 1.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 2 FEAGERVRLKNDPAVVGVVTDRPPEERAGRTFFQIELPTGRRSLPANQLEHVLAAPDALVDLRNGKLSAPTDLRRALTHL 81
Cdd:COG0553 143 AALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAF 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 82 RMTgRLADMIYSMGAT-NTEFHAYQFKPV--LKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDcRRLLVVCPKP 158
Cdd:COG0553 223 RLR-RLREALESLPAGlKATLRPYQLEGAawLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTS 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 159 LVEKWRAELRnKFNVDARICGAAELLDTLRDDQERREGFQVIASLsairpprgwddpdepaSGARADLARLLNDSaqdlF 238
Cdd:COG0553 301 LVGNWQRELA-KFAPGLRVLVLDGTRERAKGANPFEDADLVITSY----------------GLLRRDIELLAAVD----W 359
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2185807946 239 DLAIFDEAHHLRNAETMNHKLAKLVTdvSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLF 303
Cdd:COG0553 360 DLVILDEAQHIKNPATKRAKAVRALK--ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAF 422
|
|
| DpdE |
NF041062 |
protein DpdE; |
100-300 |
2.97e-23 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 102.74 E-value: 2.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 100 EFHAYQFKPVLKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDcRRLLVVCPKPLVEKWRAELRNKFNVDaricg 179
Cdd:NF041062 153 ELEPHQVAVVRRVLQDPVQRYLLADEVGLGKTIEAGLVIRQHLLDNPD-ARVLVLVPDALVRQWRRELRDKFFLD----- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 180 aaelldtlrddQERREGFQVIASlsairpprgwDDPDEPASGARAdlarllndsaqdlFDLAIFDEAHHL-RNA------ 252
Cdd:NF041062 227 -----------DFPGARVRVLSH----------EEPERWEPLLDA-------------PDLLVVDEAHQLaRLAwsgdpp 272
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2185807946 253 -ETMNHKLAKLVtDVSDYSLFLSATPINLRANDLRALLKLIDPDTFERE 300
Cdd:NF041062 273 eRARYRELAALA-HAAPRLLLLSATPVLGNEETFLALLHLLDPDLYPLD 320
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
113-299 |
6.09e-21 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 89.55 E-value: 6.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 113 LNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVCPKPLVEKWRAELrNKFNVDARIC---GAAELLDTLRD 189
Cdd:cd17919 15 LYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREF-EKWTPDLRVVvyhGSQRERAQIRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 190 DQERREGFQVIASLSAIrpprgwddpdepasgaRADLARLLNDSaqdlFDLAIFDEAHHLRNAETmnhKLAKLVTDV-SD 268
Cdd:cd17919 94 KEKLDKFDVVLTTYETL----------------RRDKASLRKFR----WDLVVVDEAHRLKNPKS---QLSKALKALrAK 150
|
170 180 190
....*....|....*....|....*....|.
gi 2185807946 269 YSLFLSATPINLRANDLRALLKLIDPDTFER 299
Cdd:cd17919 151 RRLLLTGTPLQNNLEELWALLDFLDPPFLLR 181
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
119-305 |
2.12e-13 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 69.13 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLiADEVGLGKTIEAgLIWTELVARNHDCRRLLVVCPKPLVEKWRAELRnKFNVDARiCGAAELLDTLRDDQERREGFQ 198
Cdd:cd18012 26 GIL-ADDMGLGKTLQT-LALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAA-KFAPELK-VLVIHGTKRKREKLRALEDYD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 199 -VIASLSAIRpprgwddpdepasgarADLARLLNDSaqdlFDLAIFDEAHHLRNAETMNHKLAKLVTdvSDYSLFLSATP 277
Cdd:cd18012 102 lVITSYGLLR----------------RDIELLKEVK----FHYLVLDEAQNIKNPQTKTAKAVKALK--ADHRLALTGTP 159
|
170 180 190
....*....|....*....|....*....|....
gi 2185807946 278 INLRANDLRALLKLIDP------DTFEREYLFDI 305
Cdd:cd18012 160 IENHLGELWSIFDFLNPgllgsyKRFKKRFAKPI 193
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
114-335 |
3.05e-13 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 68.85 E-value: 3.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 114 NAPSRGLLIADEVGLGKTIEA-GLIWTeLVARNHD----CRRLLVVCPKPLVEKWRAELRNKFNVdaricgaaELLDTLR 188
Cdd:cd18004 21 GYGGGGAILADEMGLGKTLQAiALVWT-LLKQGPYgkptAKKALIVCPSSLVGNWKAEFDKWLGL--------RRIKVVT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 189 DDQERREGFQVIASLSAIRPPR----GWDDpdepasgARADLARLLNDSAqdlFDLAIFDEAHHLRNAETmnhKLAKLVT 264
Cdd:cd18004 92 ADGNAKDVKASLDFFSSASTYPvliiSYET-------LRRHAEKLSKKIS---IDLLICDEGHRLKNSES---KTTKALN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 265 DVS-DYSLFLSATPINlraNDLRALLKLID---------PDTFEREYlfdilqEEnvPLVRAWEAARDT------RVPMH 328
Cdd:cd18004 159 SLPcRRRLLLTGTPIQ---NDLDEFFALVDfvnpgilgsLASFRKVF------EE--PILRSRDPDASEedkelgAERSQ 227
|
....*..
gi 2185807946 329 ELAELVG 335
Cdd:cd18004 228 ELSELTS 234
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
121-348 |
3.66e-13 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 71.41 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 121 LIADEVGLGKTIEAGLIWTE--LVARnhdCRRLLVVCPKPLVEKWRAELRNKFNVDARICGAAELLDTLRDDQERREGFQ 198
Cdd:PRK04914 173 LLADEVGLGKTIEAGMIIHQqlLTGR---AERVLILVPETLQHQWLVEMLRRFNLRFSLFDEERYAEAQHDADNPFETEQ 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 199 -VIASLSAIRpprgwDDPDepasgaradlarlLNDSAQDL-FDLAIFDEAHHL-------RNAETMNHKLAKLVTDVsdy 269
Cdd:PRK04914 250 lVICSLDFLR-----RNKQ-------------RLEQALAAeWDLLVVDEAHHLvwseeapSREYQVVEQLAEVIPGV--- 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2185807946 270 sLFLSATPINLRANDLRALLKLIDPDTFereYLFDILQEEnvplvrawEAArdtrvpMHELAELVGDLPEGRVLKTGER 348
Cdd:PRK04914 309 -LLLTATPEQLGQESHFARLRLLDPDRF---HDYEAFVEE--------QQQ------YRPVADAVQALLAGEKLSDDAL 369
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
102-307 |
5.43e-13 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 67.85 E-value: 5.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 102 HAYQFKPVLKLLN--APSRGLLIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVCPKPLVEKWRAELRnkfnvdaRICG 179
Cdd:cd18006 2 RPYQLEGVNWLLQcrAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELN-------RFAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 180 AAELLDTLRDDQERREGFQVIaslsairpprgWDDPDEPASGARADLArlLNDS---AQDLFDLAIFDEAHHLRNAETMN 256
Cdd:cd18006 75 DLSVITYMGDKEKRLDLQQDI-----------KSTNRFHVLLTTYEIC--LKDAsflKSFPWASLVVDEAHRLKNQNSLL 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2185807946 257 HKLAKLVTdvSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQ 307
Cdd:cd18006 142 HKTLSEFS--VDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKLDDFIK 190
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
96-308 |
7.49e-12 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 64.05 E-value: 7.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 96 ATNTEFHAYQFKPVLKLLNAPsRGLLIADEVGLGKTIeAGLIWTELVARNHDCRRLLVVCP-KPLVEKWRAELRNKF--- 171
Cdd:smart00487 4 FGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTL-AALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 172 -NVDARICGAAELLDTLRDDQERREGFqVIASLSAirpprgwddpdepasgaradLARLLNDSAQDL--FDLAIFDEAHH 248
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKLESGKTDI-LVTTPGR--------------------LLDLLENDKLSLsnVDLVILDEAHR 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2185807946 249 LRN---AETMNHKLAKLVTDVsdYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQE 308
Cdd:smart00487 141 LLDggfGDQLEKLLKLLPKNV--QLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
104-306 |
9.30e-12 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 65.40 E-value: 9.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPV---LKLLNAPSRGLLIADEVGLGKTIEA-GLIWTELVARNHDCRRLLVVCPKPLVEKWRAELRNKFNVDAriCG 179
Cdd:pfam00176 1 YQIEGVnwmLSLENNLGRGGILADEMGLGKTLQTiSLLLYLKHVDKNWGGPTLIVVPLSLLHNWMNEFERWVSPPA--LR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 180 AAELLDT------LRDDQERREGFQV-IASLSAIR------PPRGWDdpdepasgaradlaRLlndsaqdlfdlaIFDEA 246
Cdd:pfam00176 79 VVVLHGNkrpqerWKNDPNFLADFDVvITTYETLRkhkellKKVHWH--------------RI------------VLDEG 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2185807946 247 HHLRNAETMNHKlaKLVTDVSDYSLFLSATPINLRANDLRALLKLIDPD------TFEREYLFDIL 306
Cdd:pfam00176 133 HRLKNSKSKLSK--ALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGpfgslsTFRNWFDRPIE 196
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
120-303 |
2.51e-11 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 62.99 E-value: 2.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 120 LLIADEVGLGKTIEA-GLIWtelvARNHDCRrLLVVCPKPLVEKWRAELRNKFNVDARicGAAELLDTLRDDQERREGFQ 198
Cdd:cd18010 19 VLIADEMGLGKTVQAiAIAA----YYREEWP-LLIVCPSSLRLTWADEIERWLPSLPP--DDIQVIVKSKDGLRDGDAKV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 199 VIASLsairpprgwddpdepasgaraDLARLLNDSAQDL-FDLAIFDEAHHLRNAETMNHKLAKLVTDVSDYSLFLSATP 277
Cdd:cd18010 92 VIVSY---------------------DLLRRLEKQLLARkFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTP 150
|
170 180
....*....|....*....|....*.
gi 2185807946 278 INLRANDLRALLKLIDPDTFEREYLF 303
Cdd:cd18010 151 ALSRPIELFTQLDALDPKLFGRFHDF 176
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
100-278 |
3.23e-10 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 58.45 E-value: 3.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 100 EFHAYQFKPVLKLLNAPSRG---LLIADEVGLGKT-IEAGLIWteLVARNHDCRRLLVVCP-KPLVEKWRAELRNKFNVD 174
Cdd:pfam04851 3 ELRPYQIEAIENLLESIKNGqkrGLIVMATGSGKTlTAAKLIA--RLFKKGPIKKVLFLVPrKDLLEQALEEFKKFLPNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 175 ARICgaaELLDTLRDDQERREGFQVIASLSAIRPPRgwDDPDEPASGaradlarllndsaqDLFDLAIFDEAHHLrNAET 254
Cdd:pfam04851 81 VEIG---EIISGDKKDESVDDNKIVVTTIQSLYKAL--ELASLELLP--------------DFFDVIIIDEAHRS-GASS 140
|
170 180
....*....|....*....|....*.
gi 2185807946 255 MnhklaKLVTDVSDYS--LFLSATPI 278
Cdd:pfam04851 141 Y-----RNILEYFKPAflLGLTATPE 161
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
102-297 |
2.30e-09 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 56.62 E-value: 2.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 102 HAYQFKPV--LKLLNAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVcPKPLVEKWRAELrNKFNVDARIC- 178
Cdd:cd17998 2 KDYQLIGLnwLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVV-PSSTLDNWLREF-KRWCPSLKVEp 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 179 --GAAELLDTLRDDQERR-EGFQVIASLSAIrpprgwddpdepASGARADLARLLNDSaqdlFDLAIFDEAHHLRNAETM 255
Cdd:cd17998 80 yyGSQEERKHLRYDILKGlEDFDVIVTTYNL------------ATSNPDDRSFFKRLK----LNYVVYDEGHMLKNMTSE 143
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2185807946 256 nhKLAKLVTDVSDYSLFLSATPINLRANDLRALLKLIDPDTF 297
Cdd:cd17998 144 --RYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
119-307 |
1.08e-08 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 55.43 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLiADEVGLGKTIEAGLIwtelVARNHDCRRL---------LVVCPKPLVEKWRAELrNKFNVDA-----RICGAAELL 184
Cdd:cd17999 22 GIL-CDDMGLGKTLQTLCI----LASDHHKRANsfnsenlpsLVVCPPTLVGHWVAEI-KKYFPNAflkplAYVGPPQER 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 185 DTLRDDQERreGFQVIASLSAIrpprgwddpdepasgaRADLARLLNDSaqdlFDLAIFDEAHHLRNAETmnhKLAKLVT 264
Cdd:cd17999 96 RRLREQGEK--HNVIVASYDVL----------------RNDIEVLTKIE----WNYCVLDEGHIIKNSKT---KLSKAVK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2185807946 265 DV-SDYSLFLSATPINLRANDLRALLKLIDP------DTFEREYLFDILQ 307
Cdd:cd17999 151 QLkANHRLILSGTPIQNNVLELWSLFDFLMPgylgteKQFQRRFLKPILA 200
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
113-307 |
1.14e-08 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 55.46 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 113 LNAPSRGLLIADEVGLGKTIE-----AGLIWTELVarnhdcRRLLVVCPKPLVEKWRAELRN-KFNVDARICGAAElLDT 186
Cdd:cd18001 15 LHDGGKGGILADDMGLGKTVQicaflSGMFDSGLI------KSVLVVMPTSLIPHWVKEFAKwTPGLRVKVFHGTS-KKE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 187 LRDDQER--REGFQVIASLSAIRppRGWddpdEPASGARADLARllndsaqdlFDLAIFDEAHHLRNAETmnhKLAKLVT 264
Cdd:cd18001 88 RERNLERiqRGGGVLLTTYGMVL--SNT----EQLSADDHDEFK---------WDYVILDEGHKIKNSKT---KSAKSLR 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2185807946 265 DV-SDYSLFLSATPINlraNDLRALLKLID----------PDTFEREYLFDILQ 307
Cdd:cd18001 150 EIpAKNRIILTGTPIQ---NNLKELWALFDfacngsllgtRKTFKMEFENPITR 200
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
119-293 |
1.14e-08 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 55.24 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLIADEVGLGKTIEA-GLIWTeLVARNHD-----CRRLLVVCPKPLVEKWRAELRNKFnvdaricgAAELLDTLRDDQE 192
Cdd:cd18066 26 GAILADEMGLGKTLQCiSLIWT-LLRQGPYggkpvIKRALIVTPGSLVKNWKKEFQKWL--------GSERIKVFTVDQD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 193 RREGFQVIASLSAIrpprgwddpdepASGARADLARLLNDSAQDLFDLAIFDEAHHLRNAEtmnhklAKLVTDVSDYS-- 270
Cdd:cd18066 97 HKVEEFIASPLYSV------------LIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTS------IKTTTALTSLSce 158
|
170 180
....*....|....*....|....*
gi 2185807946 271 --LFLSATPINlraNDLRALLKLID 293
Cdd:cd18066 159 rrIILTGTPIQ---NDLQEFFALID 180
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
119-293 |
4.71e-08 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 52.71 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLIADEVGLGKTIE-----AGLIWTELVArnhdcRRLLVVCPKPLVEKWRAELrNKFNVDARICgaaeLLDTLRDDQER 193
Cdd:cd18000 21 GGILGDEMGLGKTIQiiaflAALHHSKLGL-----GPSLIVCPATVLKQWVKEF-HRWWPPFRVV----VLHSSGSGTGS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 194 REGFQVIASLSAIRPPRGWDdpdePA------SGARADLARLLNdsaqDLFDLAIFDEAHHLRNAETMNHKLAKLVTDVs 267
Cdd:cd18000 91 EEKLGSIERKSQLIRKVVGD----GGilittyEGFRKHKDLLLN----HNWQYVILDEGHKIRNPDAEITLACKQLRTP- 161
|
170 180
....*....|....*....|....*.
gi 2185807946 268 dYSLFLSATPINlraNDLRALLKLID 293
Cdd:cd18000 162 -HRLILSGTPIQ---NNLKELWSLFD 183
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
106-281 |
2.83e-07 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 51.43 E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 106 FKPVLKLLNAPSRGLLIADEVGLGKTIEA-GLIWTELV-ARNHDCRRLLVVCPKPLVEKWRAELRnKFNVDARICGAAEL 183
Cdd:cd18068 17 CESLKKTKKSPGSGCILAHCMGLGKTLQVvTFLHTVLLcEKLENFSRVLVVCPLNTVLNWLNEFE-KWQEGLKDEEKIEV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 184 --LDTLRDDQERR--------EGFQVIASLSAIRPPRGWDDPDEPASgARADLARLLNDSAQdlfDLAIFDEAHHLRNAE 253
Cdd:cd18068 96 neLATYKRPQERSyklqrwqeEGGVMIIGYDMYRILAQERNVKSREK-LKEIFNKALVDPGP---DFVVCDEGHILKNEA 171
|
170 180 190
....*....|....*....|....*....|.
gi 2185807946 254 TmnhKLAKLVTDV-SDYSLFLSATPI--NLR 281
Cdd:cd18068 172 S---AVSKAMNSIrTKRRIVLTGTPLqnNLI 199
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
117-304 |
3.17e-07 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 51.13 E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 117 SRGLLIADEVGLGKTIEA-GLI----------WTELVARNHDCRRL------LVVCPKPLVEKWRAELRNKFNVDA-RIC 178
Cdd:cd18008 14 PRGGILADEMGLGKTIQAlALIlatrpqdpkiPEELEENSSDPKKLylskttLIVVPLSLLSQWKDEIEKHTKPGSlKVY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 179 gaaelldtLRDDQERREGFQ-------VIASLSAIRppRGWDDPDEPASGAradlarLLNDSAQDLFDLA----IFDEAH 247
Cdd:cd18008 94 --------VYHGSKRIKSIEelsdydiVITTYGTLA--SEFPKNKKGGGRD------SKEKEASPLHRIRwyrvILDEAH 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2185807946 248 HLRNAETMNHKLAKLVTdvSDYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFD 304
Cdd:cd18008 158 NIKNRSTKTSRAVCALK--AERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFN 212
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
101-277 |
1.03e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 48.07 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 101 FHAYQFKPVLKLL--NAPSRGLLIAdEVGLGKTIEA-GLIWTELvarnhdCRRLLVVCP-KPLVEKWRAELRNkFNVDAR 176
Cdd:cd17926 1 LRPYQEEALEAWLahKNNRRGILVL-PTGSGKTLTAlALIAYLK------ELRTLIVVPtDALLDQWKERFED-FLGDSS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 177 ICGAAElldtlrDDQERREGFQVIASL--SAIRPPRGWDDPdepasgaradlarllndsaQDLFDLAIFDEAHHLrNAET 254
Cdd:cd17926 73 IGLIGG------GKKKDFDDANVVVATyqSLSNLAEEEKDL-------------------FDQFGLLIVDEAHHL-PAKT 126
|
170 180
....*....|....*....|....
gi 2185807946 255 mnhkLAKLVTDVSD-YSLFLSATP 277
Cdd:cd17926 127 ----FSEILKELNAkYRLGLTATP 146
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
121-309 |
1.56e-06 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 48.89 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 121 LIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVCPKPLVEKWRAELRN---KFNVDARIcGAAELLDTLRD-----DQE 192
Cdd:cd17993 24 ILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKwapDMNVIVYL-GDIKSRDTIREyefyfSQT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 193 RREGFQVIASLSAIrpprgwddpdepasgaradlarLLNDSaQDLFD-----LAIfDEAHHLRNAETMNHKlaKLVTDVS 267
Cdd:cd17993 103 KKLKFNVLLTTYEI----------------------ILKDK-AFLGSikwqyLAV-DEAHRLKNDESLLYE--ALKEFKT 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2185807946 268 DYSLFLSATPINLRANDLRALLKLIDPDTFEREYLFDILQEE 309
Cdd:cd17993 157 NNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDE 198
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
96-396 |
3.55e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 49.25 E-value: 3.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 96 ATNTEFHAYQFKPVLKLL----NAPSRGLLIADeVGLGKTIEAGliwtELVARNHDCRRLLVVCP-KPLVEKWRAELRNK 170
Cdd:COG1061 76 GTSFELRPYQQEALEALLaaleRGGGRGLVVAP-TGTGKTVLAL----ALAAELLRGKRVLVLVPrRELLEQWAEELRRF 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 171 FNvdaricgaaellDTLRDDQERREGFQV-IASLSAIRpprgwddpdepasgARADLARLLNDsaqdlFDLAIFDEAHHL 249
Cdd:COG1061 151 LG------------DPLAGGGKKDSDAPItVATYQSLA--------------RRAHLDELGDR-----FGLVIIDEAHHA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 250 RnAETMnHKLAKLVTDVsdYSLFLSATPInlRANDLRALLKLID--------PDTFEREYLFDIlqeENVPLVRAWEAAR 321
Cdd:COG1061 200 G-APSY-RRILEAFPAA--YRLGLTATPF--RSDGREILLFLFDgivyeyslKEAIEDGYLAPP---EYYGIRVDLTDER 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 322 DTRVPMHELAELVGDLPEGRVLKTGERLKRLREELEKGIVDTPanRVKLAARIEEM---------SLLGSTINRTRRRDV 392
Cdd:COG1061 271 AEYDALSERLREALAADAERKDKILRELLREHPDDRKTLVFCS--SVDHAEALAELlneagiraaVVTGDTPKKEREEIL 348
|
....
gi 2185807946 393 AEFK 396
Cdd:COG1061 349 EAFR 352
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
114-304 |
1.54e-05 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 46.13 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 114 NAPSRGLLIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVCPKPLVEKWRAELR----------NKFNVDARICGAAEL 183
Cdd:cd18007 23 SDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRRSRPLVLCPASTLYNWEDEFKkwlppdlrplLVLVSLSASKRADAR 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 184 LDTLRDDQERR-------EGFQVIASlsairpprgwdDPDEPASGARADLARLLNDSAqdlfDLAIFDEAHHLRNaetMN 256
Cdd:cd18007 103 LRKINKWHKEGgvlligyELFRNLAS-----------NATTDPRLKQEFIAALLDPGP----DLLVLDEGHRLKN---EK 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2185807946 257 HKLAKLVTDV-SDYSLFLSATPI--NLRanDLRALLKLIDPDTFEREYLFD 304
Cdd:cd18007 165 SQLSKALSKVkTKRRILLTGTPLqnNLK--EYWTMVDFARPKYLGTLKEFK 213
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
117-167 |
2.16e-05 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 45.54 E-value: 2.16e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2185807946 117 SRGLLIADEVGLGKTIEA-GLIWTeLVARNHDCRRLL----VVCPKPLVEKWRAEL 167
Cdd:cd18067 24 SHGCIMADEMGLGKTLQCiTLMWT-LLRQSPQCKPEIdkaiVVSPSSLVKNWANEL 78
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
104-297 |
8.24e-05 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 43.87 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPVLKLLNapsRGLLIADEVGLGKTIEA-GLI----------------WTELVARNHD--------CRRLLVVCPKP 158
Cdd:cd18070 4 YQRRAVNWMLV---PGGILADEMGLGKTVEVlALIllhprpdndldaadddSDEMVCCPDClvaetpvsSKATLIVCPSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 159 LVEKWRAELRNKFNVDARICgaaelldtLRDDQERREGFQ------------VIASLSAIRPPRGWDDPdEPASGARADL 226
Cdd:cd18070 81 ILAQWLDEINRHVPSSLKVL--------TYQGVKKDGALAspapeilaeydiVVTTYDVLRTELHYAEA-NRSNRRRRRQ 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2185807946 227 ARLLNDSaQDLFDL----AIFDEAHHLrnaETMNHKLAKLVTDVSDYSLF-LSATPINLRANDLRALLKLIDPDTF 297
Cdd:cd18070 152 KRYEAPP-SPLVLVewwrVCLDEAQMV---ESSTSKAAEMARRLPRVNRWcVSGTPIQRGLDDLFGLLSFLGVEPF 223
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
119-249 |
3.73e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 40.46 E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLIADEVGLGKTIEAGLIwTELVARNHDCRRLLVVCPKPLVEKWRAELRNKFNVDARIcgaaELLDTLRDDQERREGFQ 198
Cdd:cd00046 3 NVLITAPTGSGKTLAALLA-ALLLLLKKGKKVLVLVPTKALALQTAERLRELFGPGIRV----AVLVGGSSAEEREKNKL 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2185807946 199 -----VIASLSAIRPPRgwddpdepasgaRADLARLLNDsaqdlFDLAIFDEAHHL 249
Cdd:cd00046 78 gdadiIIATPDMLLNLL------------LREDRLFLKD-----LKLIIVDEAHAL 116
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
119-304 |
4.36e-04 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 41.54 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 119 GLLiADEVGLGKTIEAGLIWTEL-----VARNHdcrrlLVVCPKPLVEKWRAELRN---KFNVDARIcGAAELLDTLRDD 190
Cdd:cd17997 25 GIL-ADEMGLGKTLQTISLLGYLkhyknINGPH-----LIIVPKSTLDNWMREFKRwcpSLRVVVLI-GDKEERADIIRD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 191 QERREGFQV-IASLsairpprgwddpdEPASGARADLARLLndsaqdlFDLAIFDEAHHLRNAETmnhKLAKLVTDV-SD 268
Cdd:cd17997 98 VLLPGKFDVcITSY-------------EMVIKEKTVLKKFN-------WRYIIIDEAHRIKNEKS---KLSQIVRLFnSR 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 2185807946 269 YSLFLSATPINLRANDLRALLKLIDPDTFEREYLFD 304
Cdd:cd17997 155 NRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFD 190
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
104-298 |
9.97e-03 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 37.48 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 104 YQFKPVLKLLNAPSRGL--LIADEVGLGKTIEAGLIWTELVARNHDCRRLLVVCPKPLVEKWRAELrNKFNVDARIC--- 178
Cdd:cd18002 4 YQLKGLNWLANLYEQGIngILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEI-SRFVPQFKVLpyw 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2185807946 179 GAAELLDTLRDDQERRE------GFQVIASLSAIrpprgwddpdepasgARADLARLLNDSAQDLfdlaIFDEAHHLRNA 252
Cdd:cd18002 83 GNPKDRKVLRKFWDRKNlytrdaPFHVVITSYQL---------------VVQDEKYFQRVKWQYM----VLDEAQAIKSS 143
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2185807946 253 ETMNHKLakLVTDVSDYSLFLSATPINLRANDLRALLKLIDPDTFE 298
Cdd:cd18002 144 SSSRWKT--LLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFD 187
|
|
| |
