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Conserved domains on  [gi|2189832648|ref|WP_237592697|]
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accessory Sec system protein Asp2 [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XcbB_CpsF_sero super family cl41503
XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized ...
 80-235 3.44e-09

XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized members of this family are XcbB, as described in Neisseria meningitidis serotype X, and CpsF as described in Enterococcus faecalis serotype C. In the latter case, loss of CpsF converts capsular polysaccharide to serotype D.


The actual alignment was detected with superfamily member NF033892:

Pssm-ID: 468228  Cd Length: 291  Bit Score: 57.61  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189832648  80 EEAITEFIYSKISELGLNKNHATLTGFSKGGSAALYYGLKLNFSniVVSV-PQMKIGSYIENNWKqvaSHMMGKnytIVD 158
Cdd:NF033892  140 EDDIQELIEKVAKELGIEKDNVVLYGASKGGTGALYHGLLGDYK--TVAVdPILDDEYYLEEKND---RHFLKG---LRF 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2189832648 159 KNYLDNIlYKLLCQDTFLSRNIYLLTSEKDVQYSTEIVPYLSFFQKYTNFNLLKTHsafVREHNQVTSHHVPLLLSI 235
Cdd:NF033892  212 PDLKPDI-NALLENSNLSPENKIVIGSSNVSPQYPYIKRLNLLLSKITLINLNDSN---IKSHPDVSRNTVPEQLTL 284
 
Name Accession Description Interval E-value
XcbB_CpsF_sero NF033892
XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized ...
 80-235 3.44e-09

XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized members of this family are XcbB, as described in Neisseria meningitidis serotype X, and CpsF as described in Enterococcus faecalis serotype C. In the latter case, loss of CpsF converts capsular polysaccharide to serotype D.


Pssm-ID: 468228  Cd Length: 291  Bit Score: 57.61  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189832648  80 EEAITEFIYSKISELGLNKNHATLTGFSKGGSAALYYGLKLNFSniVVSV-PQMKIGSYIENNWKqvaSHMMGKnytIVD 158
Cdd:NF033892  140 EDDIQELIEKVAKELGIEKDNVVLYGASKGGTGALYHGLLGDYK--TVAVdPILDDEYYLEEKND---RHFLKG---LRF 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2189832648 159 KNYLDNIlYKLLCQDTFLSRNIYLLTSEKDVQYSTEIVPYLSFFQKYTNFNLLKTHsafVREHNQVTSHHVPLLLSI 235
Cdd:NF033892  212 PDLKPDI-NALLENSNLSPENKIVIGSSNVSPQYPYIKRLNLLLSKITLINLNDSN---IKSHPDVSRNTVPEQLTL 284
Asp2 pfam16929
Accessory Sec system GspB-transporter; Asp2 is a family of the SecA2/Y2 accessory Sec ...
 80-140 9.80e-06

Accessory Sec system GspB-transporter; Asp2 is a family of the SecA2/Y2 accessory Sec secretory system of Gram-positive bacteria. It is specific for large serine-rich repeat, cell-wall-anchored, glycoproteins such as GspB. Export of GspB requires the three Asp1-Asp3 proteins. Asp2, in conjunction with Asp3, probably acts as a chaperone in the early stage of GspB transport. Asp2 directly interacts with Aps1 and Asp3 to form a complex and stabilizes it; this complex is essential for substrate export. Moreover, Asp2 acetylates the GlcNAc residues on GspB. Asp1/2/3 complex stimulates the ATPase activity of SecA2 and also affects the export and glycosylation of pneumococcal serine-rich repeat proteins (PrsPs).


Pssm-ID: 435661  Cd Length: 500  Bit Score: 47.73  E-value: 9.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2189832648  80 EEAITEFIYSKISELGLNKNHATLTGFSKGGSAALYYGLKLNFSNIVVSVPQMKIGSYIEN 140
Cdd:pfam16929 328 EQQLVKIIKEKLEELGFKNSQLILSGLSMGTFGALYYGAKLSPHAIIVGKPLVNLGNIAEN 388
 
Name Accession Description Interval E-value
XcbB_CpsF_sero NF033892
XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized ...
 80-235 3.44e-09

XcbB/CpsF family capsular polysaccharide biosynthesis protein; Two partially characterized members of this family are XcbB, as described in Neisseria meningitidis serotype X, and CpsF as described in Enterococcus faecalis serotype C. In the latter case, loss of CpsF converts capsular polysaccharide to serotype D.


Pssm-ID: 468228  Cd Length: 291  Bit Score: 57.61  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2189832648  80 EEAITEFIYSKISELGLNKNHATLTGFSKGGSAALYYGLKLNFSniVVSV-PQMKIGSYIENNWKqvaSHMMGKnytIVD 158
Cdd:NF033892  140 EDDIQELIEKVAKELGIEKDNVVLYGASKGGTGALYHGLLGDYK--TVAVdPILDDEYYLEEKND---RHFLKG---LRF 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2189832648 159 KNYLDNIlYKLLCQDTFLSRNIYLLTSEKDVQYSTEIVPYLSFFQKYTNFNLLKTHsafVREHNQVTSHHVPLLLSI 235
Cdd:NF033892  212 PDLKPDI-NALLENSNLSPENKIVIGSSNVSPQYPYIKRLNLLLSKITLINLNDSN---IKSHPDVSRNTVPEQLTL 284
Asp2 pfam16929
Accessory Sec system GspB-transporter; Asp2 is a family of the SecA2/Y2 accessory Sec ...
 80-140 9.80e-06

Accessory Sec system GspB-transporter; Asp2 is a family of the SecA2/Y2 accessory Sec secretory system of Gram-positive bacteria. It is specific for large serine-rich repeat, cell-wall-anchored, glycoproteins such as GspB. Export of GspB requires the three Asp1-Asp3 proteins. Asp2, in conjunction with Asp3, probably acts as a chaperone in the early stage of GspB transport. Asp2 directly interacts with Aps1 and Asp3 to form a complex and stabilizes it; this complex is essential for substrate export. Moreover, Asp2 acetylates the GlcNAc residues on GspB. Asp1/2/3 complex stimulates the ATPase activity of SecA2 and also affects the export and glycosylation of pneumococcal serine-rich repeat proteins (PrsPs).


Pssm-ID: 435661  Cd Length: 500  Bit Score: 47.73  E-value: 9.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2189832648  80 EEAITEFIYSKISELGLNKNHATLTGFSKGGSAALYYGLKLNFSNIVVSVPQMKIGSYIEN 140
Cdd:pfam16929 328 EQQLVKIIKEKLEELGFKNSQLILSGLSMGTFGALYYGAKLSPHAIIVGKPLVNLGNIAEN 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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