|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
52-583 |
0e+00 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 603.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 52 DESITATDVEAQLLDLATAIDALHTLDARRDDLGPSLLAWKRVIDTGAHDIPTAAHAAIERDDTKIRSARSTVRLFTEAR 131
Cdd:COG0553 137 LLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAE 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 132 AAVESLRRAKI-----------QATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIA---IRADDGPHLVV 196
Cdd:COG0553 217 AAVDAFRLRRLrealeslpaglKATLRPYQLEGAAWLLFLRRLGlGGLLADDMGLGKTIQALALLLelkERGLARPVLIV 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 197 CPTSVIGNWRREIERFAPHLPLHVHHGTARALPTRVPAGTT--VLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSL 274
Cdd:COG0553 297 APTSLVGNWQRELAKFAPGLRVLVLDGTRERAKGANPFEDAdlVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATK 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 275 AAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRsATAATRLAAVIDPFILRRTKD 354
Cdd:COG0553 377 RAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGD-EEALERLRRLLRPFLLRRTKE 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 355 TVAKDLPPKQFSTVSCTLTSEQARIYRSAVADAFDTGLGT-GTARRGNILALLTTLKQVCNHPAQVTGDTDDLYGRSGKL 433
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAeGIRRRGLILAALTRLRQICSHPALLLEEGAELSGRSAKL 535
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 434 DRATEMIAEIVDDGDRALIFTQYRTMGEMLSRHLgSELGIGAiPFLHGGLNTDKRDAMVDAFQNDtDSPPVLILSLRAAG 513
Cdd:COG0553 536 EALLELLEELLAEGEKVLVFSQFTDTLDLLEERL-EERGIEY-AYLHGGTSAEERDELVDRFQEG-PEAPVFLISLKAGG 612
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 514 FGLNLTRASHVVHYDRWWNPAVEDQATDRAHRIGQKRTVNVHTLVTGGTVEDHIAAMHESKRAVADAVSG 583
Cdd:COG0553 613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
142-353 |
6.10e-101 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 305.64 E-value: 6.10e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 142 IQATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRADDG---PHLVVCPTSVIGNWRREIERFAPHLP 217
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGlGGILADDMGLGKTLQTLALLLSRKEEGrkgPSLVVAPTSLIYNWEEEAAKFAPELK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 218 LHVHHGT--ARALPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPV 295
Cdd:cd18012 81 VLVIHGTkrKREKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2192592857 296 ENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATRLAAVIDPFILRRTK 353
Cdd:cd18012 161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEEALEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
142-567 |
2.29e-81 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 276.30 E-value: 2.29e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 142 IQATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIA----IRADDGPHLVVCPTSVIGNWRREIERFAPHL 216
Cdd:PLN03142 166 IKGKMRDYQLAGLNWLIRLYENGiNGILADEMGLGKTLQTISLLGylheYRGITGPHMVVAPKSTLGNWMNEIRRFCPVL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 217 PLHVHHGTARAL-----PTRVPAGTTV-LTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAM 290
Cdd:PLN03142 246 RAVKFHGNPEERahqreELLVAGKFDVcVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLI 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 291 TGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIEsGRSATAATRLAAVIDPFILRRTKDTVAKDLPPKQFSTVSC 370
Cdd:PLN03142 326 TGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGE-NDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKV 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 371 TLTSEQARIYRSAVA---DAFDTGlgtgtARRGNILALLTTLKQVCNHP-----AQ-----VTGDtdDLYGRSGKLDRAT 437
Cdd:PLN03142 405 GMSQMQKQYYKALLQkdlDVVNAG-----GERKRLLNIAMQLRKCCNHPylfqgAEpgppyTTGE--HLVENSGKMVLLD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 438 EMIAEIVDDGDRALIFTQYRTMGEMLSRHLGSElGIGAIPfLHGGLNTDKRDAMVDAFQNDTDSPPVLILSLRAAGFGLN 517
Cdd:PLN03142 478 KLLPKLKERDSRVLIFSQMTRLLDILEDYLMYR-GYQYCR-IDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGIN 555
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2192592857 518 LTRASHVVHYDRWWNPAVEDQATDRAHRIGQKRTVNVHTLVTGGTVEDHI 567
Cdd:PLN03142 556 LATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKV 605
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
149-416 |
1.92e-76 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 244.90 E-value: 1.92e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 149 YQVHGVAWLTAL-SGSG-GGILADEMGLGKTLQAISMIA----IRADDG-PHLVVCPTSVIGNWRREIERFA--PHLPLH 219
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGrGGILADEMGLGKTLQTISLLLylkhVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 VHHGTARALPTRVPAGTT------VLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGT 293
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFladfdvVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 294 PVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATRLAAVIDPFILRRTKDTVAKDLPPKQFSTVSCTLT 373
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2192592857 374 SEQARIY----RSAVADAFDTGLGTGTARRGnILALLTTLKQVCNHP 416
Cdd:pfam00176 241 KLQRKLYqtflLKKDLNAIKTGEGGREIKAS-LLNILMRLRKICNHP 286
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
146-314 |
1.59e-69 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 222.83 E-value: 1.59e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTAL-SGSGGGILADEMGLGKTLQAISMIAI----RADDGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd17919 1 LRPYQLEGLNFLLELyENGPGGILADEMGLGKTLQAIAFLAYllkeGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTARA-----LPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPV 295
Cdd:cd17919 81 YHGSQREraqirAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160
|
170
....*....|....*....
gi 2192592857 296 ENRLEELWSLFRVANPEVL 314
Cdd:cd17919 161 QNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
146-351 |
5.33e-57 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 192.21 E-value: 5.33e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTAL-SGSGGGILADEMGLGKTLQAISMIAI-------RADD-----------------GPHLVVCPTS 200
Cdd:cd18005 1 LRDYQREGVEFMYDLyKNGRGGILGDDMGLGKTVQVIAFLAAvlgktgtRRDRennrprfkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 201 VIGNWRREIERFApHLPLHVHHGT--ARALPTRVPAG--TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAA 276
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSrkDDELEGRLKAGrlEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 277 KAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATR-----------LAAVID 345
Cdd:cd18005 160 QAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARelrlgrkrkqeLAVKLS 239
|
....*.
gi 2192592857 346 PFILRR 351
Cdd:cd18005 240 KFFLRR 245
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
146-351 |
6.69e-57 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 191.41 E-value: 6.69e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAI----RADDG-----PHLVVCPTSVIGNWRREIERFAPH 215
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNlHGILCDDMGLGKTLQTLCILASdhhkRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 216 --LPLHVHHGTA---RALPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAM 290
Cdd:cd17999 81 afLKPLAYVGPPqerRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLIL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 291 TGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATR-----------LAAVIDPFILRR 351
Cdd:cd17999 161 SGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKeqeagalaleaLHKQVLPFLLRR 232
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
146-351 |
1.77e-53 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 181.87 E-value: 1.77e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTA-LSGSGGGILADEMGLGKTLQAISMIAIRA----DDGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18006 1 LRPYQLEGVNWLLQcRAEQHGCILGDEMGLGKTCQTISLLWYLAgrlkLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHG-------TARALPTRVPAgTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGT 293
Cdd:cd18006 81 YMGdkekrldLQQDIKSTNRF-HVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 294 PVENRLEELWSLFRVANPEVLGTRA--RFRQRFAvpiESGRSATAATRLAAVIDPFILRR 351
Cdd:cd18006 160 PIQNSLQELYALLSFIEPNVFPKDKldDFIKAYS---ETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
146-351 |
6.91e-53 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 180.95 E-value: 6.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTalsgSGGGILADEMGLGKTLQAISMIAIRADDGPH---------------------LVVCPTSVIGN 204
Cdd:cd18008 1 LLPYQKQGLAWML----PRGGILADEMGLGKTIQALALILATRPQDPKipeeleenssdpkklylskttLIVVPLSLLSQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 205 WRREIERF--APHLPLHVHHGTARALPTRVPAG-TTVLTSYSVLRSDADQ----------------LAPIHWSSVVFDEA 265
Cdd:cd18008 77 WKDEIEKHtkPGSLKVYVYHGSKRIKSIEELSDyDIVITTYGTLASEFPKnkkgggrdskekeaspLHRIRWYRVILDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 266 QQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIeSGRSATAATRLAAVID 345
Cdd:cd18008 157 HNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF-SKNDRKALERLQALLK 235
|
....*.
gi 2192592857 346 PFILRR 351
Cdd:cd18008 236 PILLRR 241
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
430-558 |
9.98e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 176.90 E-value: 9.98e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 430 SGKLDRATEMIAEIVDDGDRALIFTQYRTMGEMLSRHLgSELGIGAIpFLHGGLNTDKRDAMVDAFQNDtDSPPVLILSL 509
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEAL-RERGIKYL-RLDGSTSSKERQKLVDRFNED-PDIRVFLLST 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2192592857 510 RAAGFGLNLTRASHVVHYDRWWNPAVEDQATDRAHRIGQKRTVNVHTLV 558
Cdd:cd18793 87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
146-351 |
3.86e-51 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 176.02 E-value: 3.86e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTAL-SGSGGGILADEMGLGKTLQAISMIAIRADDG---PHLVVCPTSVIGNWRREIERFAPHLPLHVH 221
Cdd:cd18001 1 LYPHQREGVAWLWSLhDGGKGGILADDMGLGKTVQICAFLSGMFDSGlikSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGTARALPTRV-----PAGTTVLTSYSVLRSDADQLAPIH-----WSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMT 291
Cdd:cd18001 81 HGTSKKERERNleriqRGGGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 292 GTPVENRLEELWSLFR-VANPEVLGTRARFRQRFAVPIESGRSATA-----------ATRLAAVIDPFILRR 351
Cdd:cd18001 161 GTPIQNNLKELWALFDfACNGSLLGTRKTFKMEFENPITRGRDKDAtqgekalgsevAENLRQIIKPYFLRR 232
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
145-353 |
5.24e-50 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 173.34 E-value: 5.24e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 145 TLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAI---RADDGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGiNGILADEMGLGKTIQTIALLAHlreRGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTA----------RALPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAM 290
Cdd:cd18009 83 YHGTKeererlrkkiMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLL 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2192592857 291 TGTPVENRLEELWSLFRVANPEVLGTRARFRQRF-----------AVPIESGRSATAATRLAAVIDPFILRRTK 353
Cdd:cd18009 163 TGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsslsdnaadISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
146-351 |
7.34e-48 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 167.14 E-value: 7.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRADD----GPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNlNGILADEMGLGKTIQTIALLAHLACEkgnwGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTARALP------TRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTP 294
Cdd:cd18003 81 YYGSAKERKlkrqgwMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2192592857 295 VENRLEELWSLFRVANPEVLGTRARFRQRFAVP----IESGRSATAAT--RLAAVIDPFILRR 351
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPltamSEGSQEENEELvrRLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
145-353 |
1.12e-46 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 163.65 E-value: 1.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 145 TLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIA----IRADDGPHLVVCPTSVIGNWRREIERFAPHLPLH 219
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGiNGILADEMGLGKTLQTISLLGylkhYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 VHHGT----ARALPTRVPAGT--TVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGT 293
Cdd:cd17997 83 VLIGDkeerADIIRDVLLPGKfdVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGT 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 294 PVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATRLAAVIDPFILRRTK 353
Cdd:cd17997 163 PLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
146-351 |
1.60e-44 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 157.80 E-value: 1.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISMI-------AIRaddGPHLVVCPTSVIGNWRREIERFAPhLP 217
Cdd:cd17995 1 LRDYQLEGVNWLLfNWYNRRNCILADEMGLGKTIQSIAFLehlyqveGIR---GPFLVIAPLSTIPNWQREFETWTD-MN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 218 LHVHHGTARA-------------LPTRVPAG----TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAM 280
Cdd:cd17995 77 VVVYHGSGESrqiiqqyemyfkdAQGRKKKGvykfDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLK 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2192592857 281 QLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd17995 157 KLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG----DLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
145-353 |
2.37e-42 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 152.52 E-value: 2.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 145 TLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIA----IRADDGPHLVVCPTSVIGNWRREIERFAPHLPLH 219
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNlNGILADEMGLGKTIQTISLITylmeKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 VHHGTA---RALPTRVPAG--TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSS-LAAKAAMQLSADVKVAMTGT 293
Cdd:cd17996 83 VYKGTPdvrKKLQSQIRAGkfNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSkLTQTLNTYYHARYRLLLTGT 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2192592857 294 PVENRLEELWSLFRVANPEVLGTRARFRQRFAVP--IESGRSATAAT---------RLAAVIDPFILRRTK 353
Cdd:cd17996 163 PLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPfaNTGEQVKIELNeeetlliirRLHKVLRPFLLRRLK 233
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
146-351 |
2.60e-42 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 152.44 E-value: 2.60e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWL----TALSGSGGG--ILADEMGLGKTLQAISMIAI----RADDGPH----LVVCPTSVIGNWRREIER 211
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGgaILADEMGLGKTLQAIALVWTllkqGPYGKPTakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 212 FAPHLPLHVHHGTARALPTRV------PAGTT--VLTSYSVLRSDADQLA-PIHWSSVVFDEAQQIKNPSSLAAKAAMQL 282
Cdd:cd18004 81 WLGLRRIKVVTADGNAKDVKAsldffsSASTYpvLIISYETLRRHAEKLSkKISIDLLICDEGHRLKNSESKTTKALNSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 283 SADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATA-----------ATRLAAVIDPFILRR 351
Cdd:cd18004 161 PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDAseedkelgaerSQELSELTSRFILRR 240
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
146-306 |
4.63e-41 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 147.47 E-value: 4.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAI----RADDGPHLVVCPTSVIGNWRREIERFAPhlPLHV 220
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRvGGILGDEMGLGKTIQIIAFLAAlhhsKLGLGPSLIVCPATVLKQWVKEFHRWWP--PFRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 ----HHGTARA--------------LPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQL 282
Cdd:cd18000 79 vvlhSSGSGTGseeklgsierksqlIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQL 158
|
170 180
....*....|....*....|....
gi 2192592857 283 SADVKVAMTGTPVENRLEELWSLF 306
Cdd:cd18000 159 RTPHRLILSGTPIQNNLKELWSLF 182
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
146-351 |
1.30e-40 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 147.65 E-value: 1.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRADD----GPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGiNGILADEMGLGKTVQSIAVLAHLAEEhniwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTA------------RALPTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKV 288
Cdd:cd18002 81 YWGNPkdrkvlrkfwdrKNLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2192592857 289 AMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAA------TRLAAVIDPFILRR 351
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGlnehqlKRLHMILKPFMLRR 229
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
165-351 |
1.10e-37 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 139.91 E-value: 1.10e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 165 GGILADEMGLGKTLQAISMIAIRaddgPHLVVCPTSVIGNWRREIERFAP--HLPLHVHHGTARAL-PTRVPAGTTVLTS 241
Cdd:cd18071 50 GGILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEEHVKpgQLKVYTYHGGERNRdPKLLSKYDIVLTT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 242 YSVLRSD-----ADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGT 316
Cdd:cd18071 126 YNTLASDfgakgDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSN 205
|
170 180 190
....*....|....*....|....*....|....*
gi 2192592857 317 RARFRQRFAVPIESGrSATAATRLAAVIDPFILRR 351
Cdd:cd18071 206 PEYWRRLIQRPLTMG-DPTGLKRLQVLMKQITLRR 239
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
146-364 |
6.67e-37 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 137.87 E-value: 6.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAI----RADDGPHLVVCPTSVIGNWRREIERFAPHLP--L 218
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGiNGILADEMGLGKTLQTISLLGYmkhyRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRavC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 219 HVHHGTARALPTR---VPAGTTV-LTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTP 294
Cdd:cd18064 96 LIGDKDQRAAFVRdvlLPGEWDVcVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 295 VENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGrSATAATRLAAVIDPFILRRTKDTVAKDLPPKQ 364
Cdd:cd18064 176 LQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLG-DQKLVERLHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
145-351 |
1.41e-36 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 135.95 E-value: 1.41e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 145 TLRPYQVHGVAWLTAL-SGSGGGILADEMGLGKTLQAISMIA----IRADDGPHLVVCPTSVIGNWRREIERFAPHLPLH 219
Cdd:cd17993 1 ELRDYQLTGLNWLAHSwCKGNNGILADEMGLGKTVQTISFLSylfhSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 VHHGT--ARAL---------PTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKV 288
Cdd:cd17993 81 VYLGDikSRDTireyefyfsQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2192592857 289 AMTGTPVENRLEELWSLFRVANPEvlgtraRFRQRFAVPIESGRSATAA-TRLAAVIDPFILRR 351
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPG------KFDIWEEFEEEHDEEQEKGiADLHKELEPFILRR 218
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
146-351 |
1.73e-36 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 136.45 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWL------TALSGSGGGILADEMGLGKTLQAISMIAIRADDGPH--------LVVCPTSVIGNWRREIER 211
Cdd:cd18067 1 LRPHQREGVKFLyrcvtgRRIRGSHGCIMADEMGLGKTLQCITLMWTLLRQSPQckpeidkaIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 212 F--APHLPLHVHHGT-----------ARALPTRVPAgTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKA 278
Cdd:cd18067 81 WlgGRLQPLAIDGGSkkeidrklvqwASQQGRRVST-PVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 279 AMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATR-----------LAAVIDPF 347
Cdd:cd18067 160 LDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKerqlgeeklqeLISIVNRC 239
|
....
gi 2192592857 348 ILRR 351
Cdd:cd18067 240 IIRR 243
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
146-331 |
5.11e-36 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 135.11 E-value: 5.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGV-------AWLTALSGSGGG-ILADEMGLGKTLQAISMIAIRADDGPH----LVVCPTSVIGNWRREIERFA 213
Cdd:cd18007 1 LKPHQVEGVrflwsnlVGTDVGSDEGGGcILAHTMGLGKTLQVITFLHTYLAAAPRrsrpLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 214 P--HLPLHVHHGTARAL-PTRVPA--------GTTVLTSYSVLR---SDADQLAPIHWSS-----------VVFDEAQQI 268
Cdd:cd18007 81 PpdLRPLLVLVSLSASKrADARLRkinkwhkeGGVLLIGYELFRnlaSNATTDPRLKQEFiaalldpgpdlLVLDEGHRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2192592857 269 KNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESG 331
Cdd:cd18007 161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAG 223
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
146-314 |
1.30e-35 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 132.12 E-value: 1.30e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIA---IRADDGPHLVVCPTSVIGNWRREIERFAPHLPLHVH 221
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKlSGILADEMGLGKTIQVIAFLAylkEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGTA---RALPTRVPAGTT----VLTSYSVLRSDADQ---LAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMT 291
Cdd:cd17998 81 YGSQeerKHLRYDILKGLEdfdvIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|....*
gi 2192592857 292 GTPVENRLEELWSL--FRVANPEVL 314
Cdd:cd17998 161 GTPLQNNLLELMSLlnFIMPKPFIL 185
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
146-351 |
2.20e-34 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 130.35 E-value: 2.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWL------TALSGSGGGILADEMGLGKTLQAISMIAIRADDGPH---------LVVCPTSVIGNWRREIE 210
Cdd:cd18066 1 LRPHQREGIEFLyecvmgMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYggkpvikraLIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 211 RFAphlplhvhhGTARALPTRV------------PAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKA 278
Cdd:cd18066 81 KWL---------GSERIKVFTVdqdhkveefiasPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 279 AMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATA-----------ATRLAAVIDPF 347
Cdd:cd18066 152 LTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTAtpeekklgearAAELTRLTGLF 231
|
....
gi 2192592857 348 ILRR 351
Cdd:cd18066 232 ILRR 235
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
144-353 |
5.72e-34 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 129.37 E-value: 5.72e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 144 ATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAI----RADDGPHLVVCPTSVIGNWRREIERFAPHLPL 218
Cdd:cd18065 14 GTLRDYQVRGLNWMISLYENGvNGILADEMGLGKTLQTIALLGYlkhyRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 219 --HVHHGTARALPTR---VPAGTTV-LTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTG 292
Cdd:cd18065 94 vcLIGDKDARAAFIRdvmMPGEWDVcVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2192592857 293 TPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGrSATAATRLAAVIDPFILRRTK 353
Cdd:cd18065 174 TPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLG-DQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
127-353 |
1.18e-33 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 129.03 E-value: 1.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 127 FTEARAAVESLRRAK---IQATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRAD----DGPHLVVCP 198
Cdd:cd18063 2 YTVAHAITERVEKQSsllINGTLKHYQLQGLEWMVSLYNNNlNGILADEMGLGKTIQTIALITYLMEhkrlNGPYLIIVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 199 TSVIGNWRREIERFAPHLPLHVHHGTA---RALPTRVPAG--TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNP-S 272
Cdd:cd18063 82 LSTLSNWTYEFDKWAPSVVKISYKGTPamrRSLVPQLRSGkfNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHhC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 273 SLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVP---------IESGRSATAATRLAAV 343
Cdd:cd18063 162 KLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfamtgervdLNEEETILIIRRLHKV 241
|
250
....*....|
gi 2192592857 344 IDPFILRRTK 353
Cdd:cd18063 242 LRPFLLRRLK 251
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
146-351 |
1.29e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 128.58 E-value: 1.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISMIAIRADD----GPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18054 21 LRDYQLEGLNWLAhSWCKNNSVILADEMGLGKTIQTISFLSYLFHQhqlyGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHG------TARALP-----TRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVA 289
Cdd:cd18054 101 YIGdlmsrnTIREYEwihsqTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 290 MTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSAtaatrLAAVIDPFILRR 351
Cdd:cd18054 181 ITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQS-----LHKVLEPFLLRR 237
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
146-332 |
2.57e-33 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 126.55 E-value: 2.57e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWltALSGSGGGILADEMGLGKTLQAISMIAIRADDGPHLVVCPTSVIGNWRREIERFAPHLPLH----VH 221
Cdd:cd18010 1 LLPFQREGVCF--ALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDdiqvIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGT--ARALPTRVpagttVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAM--TGTPVEN 297
Cdd:cd18010 79 KSKdgLRDGDAKV-----VIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVIllSGTPALS 153
|
170 180 190
....*....|....*....|....*....|....*
gi 2192592857 298 RLEELWSLFRVANPEVLGTRARFRQRFAVPIESGR 332
Cdd:cd18010 154 RPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGF 188
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
146-351 |
3.51e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 121.70 E-value: 3.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSGGG-ILADEMGLGKTLQAISMIAIRADD----GPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNScILADEMGLGKTIQTISFLNYLFHEhqlyGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHG--TARAL---------PTRVPAGTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVA 289
Cdd:cd18053 101 YLGdiNSRNMirthewmhpQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 290 MTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRsataaTRLAAVIDPFILRR 351
Cdd:cd18053 181 ITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGY-----ASLHKELEPFLLRR 237
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
127-353 |
4.69e-31 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 121.69 E-value: 4.69e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 127 FTEARAAVESLRRAK---IQATLRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRAD----DGPHLVVCP 198
Cdd:cd18062 2 YAVAHAVTEKVEKQSsllVNGVLKQYQIKGLEWLVSLYNNNlNGILADEMGLGKTIQTIALITYLMEhkriNGPFLIIVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 199 TSVIGNWRREIERFAPHLPLHVHHGTARALPTRVP---AG--TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNP-S 272
Cdd:cd18062 82 LSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFVPqlrSGkfNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHhC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 273 SLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVP---------IESGRSATAATRLAAV 343
Cdd:cd18062 162 KLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfamtgekvdLNEEETILIIRRLHKV 241
|
250
....*....|
gi 2192592857 344 IDPFILRRTK 353
Cdd:cd18062 242 LRPFLLRRLK 251
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
146-351 |
9.42e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 119.08 E-value: 9.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG-GGILADEMGLGKTLQAISMIAIRADD----GPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGtDTILADEMGLGKTIQTIVFLYSLYKEghskGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTaralptrvpagTTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLE 300
Cdd:cd17994 81 YVGD-----------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLE 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2192592857 301 ELWSLFRVANPEVLGTRARFRQRFAVPIESGRsataATRLAAVIDPFILRR 351
Cdd:cd17994 150 ELFHLLNFLTPERFNNLQGFLEEFADISKEDQ----IKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
146-351 |
1.34e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 116.67 E-value: 1.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISM---IAIRADDGPHLVVCPTSVIGNWRREIeRFAPHLPLHVH 221
Cdd:cd18059 1 LREYQLEGVNWLLfNWYNTRNCILADEMGLGKTIQSITFlyeIYLKGIHGPFLVIAPLSTIPNWEREF-RTWTELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGTARALPT-------------RVPAGT----TVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSA 284
Cdd:cd18059 80 HGSQASRRTiqlyemyfkdpqgRVIKGSykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2192592857 285 DVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18059 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFG----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
146-351 |
3.89e-29 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 115.14 E-value: 3.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISM---IAIRADDGPHLVVCPTSVIGNWRREIeRFAPHLPLHVH 221
Cdd:cd18058 1 LREYQLEGMNWLLfNWYNRKNCILADEMGLGKTIQSITFlseIFLMGIRGPFLIIAPLSTITNWEREF-RTWTEMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGTARA--------LPTRVPAGT---------TVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSA 284
Cdd:cd18058 80 HGSQISrqmiqqyeMYYRDEQGNplsgifkfqVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMAL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2192592857 285 DVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18058 160 EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG----DLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
146-351 |
1.50e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 110.91 E-value: 1.50e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISMIAIRADDG---PHLVVCPTSVIGNWRREIERFApHLPLHVH 221
Cdd:cd18060 1 LREYQLEGVNWLLfNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGihgPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGT--ARALPTR------------VPAG---TTVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSA 284
Cdd:cd18060 80 HGSlaSRQMIQQyemyckdsrgrlIPGAykfDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2192592857 285 DVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18060 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
146-351 |
1.69e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 110.48 E-value: 1.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLT-ALSGSGGGILADEMGLGKTLQAISM---IAIRADDGPHLVVCPTSVIGNWRREIeRFAPHLPLHVH 221
Cdd:cd18061 1 LREYQLEGLNWLLfNWYNRRNCILADEMGLGKTIQSITFlyeILLTGIRGPFLIIAPLSTIANWEREF-RTWTDLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 222 HGTA-------------RALPTRVPAGT----TVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSA 284
Cdd:cd18061 80 HGSLisrqmiqqyemyfRDSQGRIIRGAyrfqAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2192592857 285 DVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFG----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
146-351 |
6.18e-27 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 109.49 E-value: 6.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSG--GGILADEMGLGKTLQAISMI--------------------AIRADD------GPHLVVC 197
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKprGGILADDMGLGKTLTMIALIlaqkntqnrkeeekekalteWESKKDstlvpsAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 198 PTSVIGNWRREIERFAPH--LPLHVHHGTARALPTRVPAG-TTVLTSYSVLRSD---------ADQLAPIHWSSVVFDEA 265
Cdd:cd18072 81 PASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVLRDyDIVITTYSLVAKEiptykeesrSSPLFRIAWARIILDEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 266 QQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFavpieSGRSATAATRLAAVID 345
Cdd:cd18072 161 HNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQV-----DNKSRKGGERLNILTK 235
|
....*.
gi 2192592857 346 PFILRR 351
Cdd:cd18072 236 SLLLRR 241
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
146-351 |
9.12e-26 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 105.92 E-value: 9.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSGGG-ILADEMGLGKTLQAI----SMIAIRADDGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDtILADEMGLGKTVQTIvflySLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTARALP-----------TRVPAGTTV--------------LTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLA 275
Cdd:cd18057 81 YTGDKESRSvirenefsfedNAIRSGKKVfrmkkeaqikfhvlLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2192592857 276 AKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA----DISKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
146-307 |
2.02e-24 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 102.81 E-value: 2.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALsgsgGGILADEMGLGKTLQAISMIA---------IRADD--------------------GPHLVV 196
Cdd:cd18070 1 LLPYQRRAVNWMLVP----GGILADEMGLGKTVEVLALILlhprpdndlDAADDdsdemvccpdclvaetpvssKATLIV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 197 CPTSVIGNWRREIERFAP-HLPLHVHHG------TARALPTRVPAGTTVLTSYSVLRSD-------------ADQ----- 251
Cdd:cd18070 77 CPSAILAQWLDEINRHVPsSLKVLTYQGvkkdgaLASPAPEILAEYDIVVTTYDVLRTElhyaeanrsnrrrRRQkryea 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 252 ----LAPIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFR 307
Cdd:cd18070 157 ppspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLS 216
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
146-351 |
6.75e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 100.47 E-value: 6.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSGGG-ILADEMGLGKTLQAI----SMIAIRADDGPHLVVCPTSVIGNWRREIERFAPHLPL-- 218
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDtILADEMGLGKTIQTIvflySLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 219 --------------------HVHHGTARALPTRVPAGT---TVLTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLA 275
Cdd:cd18055 81 ytgdkdsraiirenefsfddNAVKGGKKAFKMKREAQVkfhVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2192592857 276 AKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAvpieSGRSATAATRLAAVIDPFILRR 351
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA----DISKEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
146-351 |
6.95e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 100.52 E-value: 6.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLTALSGSGGG-ILADEMGLGKTLQ-AISMIAIRAD---DGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDtILADEMGLGKTVQtAVFLYSLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHG--TARAL------------------PTRVPAGTTV-----LTSYSVLRSDADQLAPIHWSSVVFDEAQQIKNPSSLA 275
Cdd:cd18056 81 YVGdkDSRAIirenefsfednairggkkASRMKKEASVkfhvlLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2192592857 276 AKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRsataATRLAAVIDPFILRR 351
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQ----IKKLHDMLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
146-339 |
1.23e-21 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 94.57 E-value: 1.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWL----------TALSGSGGGILADEMGLGKTLQAISMIAI------RADDGPHLVVCPTSVIGNWRREI 209
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkkTKKSPGSGCILAHCMGLGKTLQVVTFLHTvllcekLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 210 ERFAPHL----PLHVHH-GTARALPTRVPA-------GTTVLTSYSVLRSDADQLAPIHWSS----------------VV 261
Cdd:cd18068 81 EKWQEGLkdeeKIEVNElATYKRPQERSYKlqrwqeeGGVMIIGYDMYRILAQERNVKSREKlkeifnkalvdpgpdfVV 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2192592857 262 FDEAQQIKNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGRSATAATR 339
Cdd:cd18068 161 CDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLV 238
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
145-307 |
2.46e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.17 E-value: 2.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 145 TLRPYQVHGVAWLtaLSGSGGGILADEMGLGKTLQAISMIA---IRADDGPHLVVCPTSV-IGNWRREIERFAPHLPLH- 219
Cdd:smart00487 8 PLRPYQKEAIEAL--LSGLRDVILAAPTGSGKTLAALLPALealKRGKGGRVLVLVPTRElAEQWAEELKKLGPSLGLKv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 --VHHGTARALPTRVPAGTT---VLTSYSVLRSDADQ--LAPIHWSSVVFDEAQQIKNPS--SLAAKAAMQLSADVK-VA 289
Cdd:smart00487 86 vgLYGGDSKREQLRKLESGKtdiLVTTPGRLLDLLENdkLSLSNVDLVILDEAHRLLDGGfgDQLEKLLKLLPKNVQlLL 165
|
170
....*....|....*...
gi 2192592857 290 MTGTPVENRLEELWSLFR 307
Cdd:smart00487 166 LSATPPEEIENLLELFLN 183
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
431-547 |
7.66e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 87.65 E-value: 7.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 431 GKLDRATEMIAEivDDGDRALIFTQYRTMGEMlsRHLGSELGIGAIPfLHGGLNTDKRDAMVDAFQNDTDSppvLILSLR 510
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA--ELLLEKEGIKVAR-LHGDLSQEEREEILEDFRKGKID---VLVATD 72
|
90 100 110
....*....|....*....|....*....|....*..
gi 2192592857 511 AAGFGLNLTRASHVVHYDRWWNPAVEDQATDRAHRIG 547
Cdd:pfam00271 73 VAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
146-332 |
3.70e-20 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 89.49 E-value: 3.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWL--------TALSGSGG--GILADEMGLGKTLQAISM--IAIRADDGPH-LVVCPTSVIGNWRREIERF 212
Cdd:cd18069 1 LKPHQIGGIRFLydniieslERYKGSSGfgCILAHSMGLGKTLQVISFldVLLRHTGAKTvLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 213 APHL---------PLHVH-----HGTARA----LPTRVPAGTTVLTSYSVLR-SDADQLapihwssVVFDEAQQIKNPSS 273
Cdd:cd18069 81 LPPPealpnvrprPFKVFilndeHKTTAArakvIEDWVKDGGVLLMGYEMFRlRPGPDV-------VICDEGHRIKNCHA 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2192592857 274 LAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQRFAVPIESGR 332
Cdd:cd18069 154 STSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQ 212
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
146-322 |
2.21e-17 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 81.18 E-value: 2.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVawLTAL-SGSGGGILADEMGLGKTLQAIsMIA----IRADDGPHLVVCPTSVIGNWRREIERFAPHLPLHV 220
Cdd:cd18011 1 PLPHQIDAV--LRALrKPPVRLLLADEVGLGKTIEAG-LIIkellLRGDAKRVLILCPASLVEQWQDELQDKFGLPFLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 221 HHGTARALPTRVPAGTT----VLTSYSVLRSD---ADQLAPIHWSSVVFDEAQQIKN----PSSLAAKAAMQLSADVK-- 287
Cdd:cd18011 78 DRETAAQLRRLIGNPFEefpiVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNsgggKETKRYKLGRLLAKRARhv 157
|
170 180 190
....*....|....*....|....*....|....*
gi 2192592857 288 VAMTGTPVENRLEELWSLFRVANPEVLGTRARFRQ 322
Cdd:cd18011 158 LLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLR 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
461-547 |
7.58e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 75.71 E-value: 7.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 461 EMLSRHLgSELGIGAIPfLHGGLNTDKRDAMVDAFQNDTDsppVLILSLRAAGFGLNLTRASHVVHYDRWWNPAVEDQAT 540
Cdd:smart00490 1 EELAELL-KELGIKVAR-LHGGLSQEEREEILDKFNNGKI---KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRI 75
|
....*..
gi 2192592857 541 DRAHRIG 547
Cdd:smart00490 76 GRAGRAG 82
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
146-328 |
1.45e-16 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 78.93 E-value: 1.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 146 LRPYQVHGVAWLtaLSGSGGGILADeMGLGKTLQAISMIA-IRADDGPH--LVVCPTSVIGN-WRREIERFA--PHLPLH 219
Cdd:cd18013 1 PHPYQKVAINFI--IEHPYCGLFLD-MGLGKTVTTLTALSdLQLDDFTRrvLVIAPLRVARStWPDEVEKWNhlRNLTVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 220 VHHGTARAlptRVPAGTTVLTSYSVLRSDADQLA-----PIHWSSVVFDEAQQIKNPSSLAAKAAMQLSADVK--VAMTG 292
Cdd:cd18013 78 VAVGTERQ---RSKAANTPADLYVINRENLKWLVnksgdPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKrlIGLTG 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 2192592857 293 TPVENRLEELWSLFRVAN-PEVLG-TRARFRQRFAVPI 328
Cdd:cd18013 155 TPSPNGLMDLWAQIALLDqGERLGrSITAYRERWFDPD 192
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
80-525 |
8.32e-14 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 74.29 E-value: 8.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 80 RRDDLGPSLLAWKRVIDTGAHDIPTAAHAAIERDDTKIRSARSTVRLFTEARAAVESLRRAKIQATLRPYQVHGV-AWLT 158
Cdd:COG1061 15 RSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFELRPYQQEALeALLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 159 ALSGSGG-GILADEMGLGKTLQAISMIAIRADDGPHLVVCPTSVIGN-WRREIERFaphLPLHVHHGTARALPTRVpagt 236
Cdd:COG1061 95 ALERGGGrGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRRELLEqWAEELRRF---LGDPLAGGGKKDSDAPI---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 237 tVLTSYSVLRSDA--DQLAPiHWSSVVFDEAQQIknPSSLAAKAAMQLSADVKVAMTGTPV-ENRLEELWSLFrvanpev 313
Cdd:COG1061 168 -TVATYQSLARRAhlDELGD-RFGLVIIDEAHHA--GAPSYRRILEAFPAAYRLGLTATPFrSDGREILLFLF------- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 314 lgtrarFRQRFAVPIesgRSATAATRLAavidPFILRrtkdtvakdlppkqfsTVSCTLTSEQARIyrSAVADAFDTGLG 393
Cdd:COG1061 237 ------DGIVYEYSL---KEAIEDGYLA----PPEYY----------------GIRVDLTDERAEY--DALSERLREALA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 394 TGTARrgnilallttlkqvcnhpaqvtgdtddlygrsgKLDRATEMIAEIVDDgDRALIFTQYRTMGEMLSRHLGsELGI 473
Cdd:COG1061 286 ADAER---------------------------------KDKILRELLREHPDD-RKTLVFCSSVDHAEALAELLN-EAGI 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 474 gAIPFLHGGLNTDKRDAMVDAFQNDTDsppVLILSLRAAGFGLNLTRASHVV 525
Cdd:COG1061 331 -RAAVVTGDTPKKEREEILEAFRDGEL---RILVTVDVLNEGVDVPRLDVAI 378
|
|
| DpdE |
NF041062 |
protein DpdE; |
168-361 |
1.28e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 54.98 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 168 LADEMGLGKTLQAiSMIaIRA---DDGPH--LVVCPTSVIGNWRRE-IERFaphlplHVHHgtaralptrVPAGTTVLTS 241
Cdd:NF041062 175 LADEVGLGKTIEA-GLV-IRQhllDNPDArvLVLVPDALVRQWRRElRDKF------FLDD---------FPGARVRVLS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 242 YsvlrSDADQLAPIHWSS--VVFDEAQQI---------KNPSSLAAKAAMQLSADVKVAMTGTPVENRLEELWSLFRVAN 310
Cdd:NF041062 238 H----EEPERWEPLLDAPdlLVVDEAHQLarlawsgdpPERARYRELAALAHAAPRLLLLSATPVLGNEETFLALLHLLD 313
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2192592857 311 PEV--LGTRARFRQRFAVPIESGRSATAatrLAAVIDPFILRRTKDTVAKDLP 361
Cdd:NF041062 314 PDLypLDDLEAFRERLEEREELGRLVLG---LDPDNPNFLLRQALDELRALFP 363
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
432-602 |
6.10e-07 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 52.42 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 432 KLDRATEMIAEI--VDDGDRALIFTQYRTMGEMLSRHLgSELGIGAIPFL-------HGGLNTDKRDAMVDAFQNDTDSp 502
Cdd:COG1111 336 KLSKLREILKEQlgTNPDSRIIVFTQYRDTAEMIVEFL-SEPGIKAGRFVgqaskegDKGLTQKEQIEILERFRAGEFN- 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 503 pVLIlSLRAAGFGLNLTRASHVVHYDRWWNPAVEDQatdRAHRIGQKRTVNVHTLVTGGTVEDhiAAMHESKRAVADAVS 582
Cdd:COG1111 414 -VLV-ATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQ---RKGRTGRKREGRVVVLIAKGTRDE--AYYWSSRRKEKKMKS 486
|
170 180
....*....|....*....|..
gi 2192592857 583 --GNVEAALADLPDTELRELLE 602
Cdd:COG1111 487 ilKKLKKLLDKQEKEKLKESAQ 508
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
446-551 |
1.19e-06 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 47.89 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 446 DGDRALIFTQYRTMGEMLSRHLgSELGIGAIPfLHGGLNTDKRDAMVDAFQNDtdSPPVLIlslrA---AGFGLNLTRAS 522
Cdd:cd18787 26 KPGKAIIFVNTKKRVDRLAELL-EELGIKVAA-LHGDLSQEERERALKKFRSG--KVRVLV----AtdvAARGLDIPGVD 97
|
90 100
....*....|....*....|....*....
gi 2192592857 523 HVVHYDrwwnpaVEDQATDRAHRIGqkRT 551
Cdd:cd18787 98 HVINYD------LPRDAEDYVHRIG--RT 118
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
432-491 |
4.72e-05 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 46.41 E-value: 4.72e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2192592857 432 KLDRATEMIAEIVD--DGDRALIFTQYRTMGEMLSRHLGSElGIGAIPFLhGGLNTDKRDAM 491
Cdd:PRK13766 348 KLEKLREIVKEQLGknPDSRIIVFTQYRDTAEKIVDLLEKE-GIKAVRFV-GQASKDGDKGM 407
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
444-551 |
6.42e-05 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 45.52 E-value: 6.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 444 VDDGDRALIFTQYRTMGEMLSRHLgSELGIGAIPfLHGGLNTDKRDAMVDAFQNDTdsPPVLIlslrA---AGFGLNLTR 520
Cdd:COG0513 238 DEDPERAIVFCNTKRGADRLAEKL-QKRGISAAA-LHGDLSQGQRERALDAFRNGK--IRVLV----AtdvAARGIDIDD 309
|
90 100 110
....*....|....*....|....*....|.
gi 2192592857 521 ASHVVHYDrwwnpaVEDQATDRAHRIGqkRT 551
Cdd:COG0513 310 VSHVINYD------LPEDPEDYVHRIG--RT 332
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
505-549 |
1.19e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.77 E-value: 1.19e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2192592857 505 LILSLRAAGFGLNLTRASHVVHYDRWWNPAVEDQATDRAHRIGQK 549
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
165-265 |
1.30e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 39.69 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 165 GGILADEMGLGKTLQAiSMIAIRADDGPH---LVVCPTSVIGN-WRREI-ERFAPHLPLHVHHGTARALPTRVPAGTT-- 237
Cdd:cd00046 3 NVLITAPTGSGKTLAA-LLAALLLLLKKGkkvLVLVPTKALALqTAERLrELFGPGIRVAVLVGGSSAEEREKNKLGDad 81
|
90 100 110
....*....|....*....|....*....|..
gi 2192592857 238 -VLTSYSVLRSDADQLAPIH---WSSVVFDEA 265
Cdd:cd00046 82 iIIATPDMLLNLLLREDRLFlkdLKLIIVDEA 113
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
432-551 |
1.69e-03 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 41.30 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 432 KLDRATEMIAEIVDDGDRALIFTQYRTMGEMLSRhlgsELGIGAIPFL--HGGLNTDKRDAMVDAFQNDTDspPVLIlSL 509
Cdd:PTZ00110 362 KRGKLKMLLQRIMRDGDKILIFVETKKGADFLTK----ELRLDGWPALciHGDKKQEERTWVLNEFKTGKS--PIMI-AT 434
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2192592857 510 RAAGFGLNLTRASHVVHYDrwwnpaVEDQATDRAHRIGqkRT 551
Cdd:PTZ00110 435 DVASRGLDVKDVKYVINFD------FPNQIEDYVHRIG--RT 468
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
447-547 |
3.26e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 40.47 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2192592857 447 GDRALIFTQYRTMGEMLSRHLGSElGIGAIPFlHGGLNTDKRDAMVDAFQNDTDSppvLILSLRAAGFGLNLTRASHVVH 526
Cdd:PRK11057 236 GKSGIIYCNSRAKVEDTAARLQSR-GISAAAY-HAGLDNDVRADVQEAFQRDDLQ---IVVATVAFGMGINKPNVRFVVH 310
|
90 100
....*....|....*....|.
gi 2192592857 527 YDRWWNPAVEDQATDRAHRIG 547
Cdd:PRK11057 311 FDIPRNIESYYQETGRAGRDG 331
|
|
| |
