|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09193 |
PRK09193 |
indolepyruvate ferredoxin oxidoreductase; Validated |
1-1157 |
0e+00 |
|
indolepyruvate ferredoxin oxidoreductase; Validated
Pssm-ID: 236404 [Multi-domain] Cd Length: 1165 Bit Score: 2120.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1 MSLADIRLDDKYRLATGNLYLTGTQALTRLPMLQKQRDEARGLNTAGFISGYRGSPLGNLDKSLWDAKDYLQQNAIHFQP 80
Cdd:PRK09193 8 MALADVTLDDKYTLERGRVFLTGTQALVRLPLLQRERDRAAGLNTAGFVSGYRGSPLGGLDQELWRAKKHLAAHDIVFQP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 81 GINEELAATAVWGSQQVNLFPHGKYDGVFALWYGKGPGVDRCGDVFKHGNSAGVAANGGVLILAGDDHGCKSSTIAHQSE 160
Cdd:PRK09193 88 GLNEDLAATAVWGSQQVNLFPGAKYDGVFGMWYGKGPGVDRSGDVFRHANAAGTSPHGGVLALAGDDHAAKSSTLPHQSE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 161 HAFIASMIPVLNPSNVQEILDYGIIGWELSRYSGCWVAMKTIAENVDSSAVVEVDPLRIKTRIPDDFDLPEGGLHIRWPD 240
Cdd:PRK09193 168 HAFKAAGMPVLFPANVQEILDYGLHGWAMSRYSGLWVGMKTVTDVVESSASVDVDPDRVQIVLPEDFEMPPGGLNIRWPD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 241 PPLAQEARLNTYKIYAARAFARANQLNKVVIDSAQPRLGIITTGKSYLDVRQALEELGIDQELCEKVGIRVLKVGMSWPL 320
Cdd:PRK09193 248 PPLEQEARLLDYKLYAALAYARANKLDRVVIDSPNARLGIVAAGKAYLDVRQALRDLGLDEETAARLGIRLYKVGMVWPL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 321 EPVSVHDFAEGLDEILVVEEKRSVIEDQLTGQLYNWPVERRPVVVGEFDEQGRSLLPNLSELTPAMIARVIAKRLAPF-- 398
Cdd:PRK09193 328 EPQGVRAFAEGLDEILVVEEKRQIIEYQLKEELYNWPDDVRPRVIGKFDPQGNWLLPAHGELSPAIIAKAIARRLLKLel 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 399 --YSSPQIEARLQFLSDKEQALQAPLFNTQRTPHFCSGCPHNTSTKVPEGSRALAGIGCHYMTIWMDRETDTFTQMGGEG 476
Cdd:PRK09193 408 pgDVRARIAARLAVLEAKEAALALPRVTAARTPYFCSGCPHNTSTRVPEGSRALAGIGCHYMATWMDRNTSTFTQMGGEG 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 477 VTWIGQAPFTETPHVFQNLGDGTYFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLRVDQLSRQVFNEGVLR 556
Cdd:PRK09193 488 VPWIGQAPFTDEKHVFQNLGDGTYFHSGLLAIRAAVAAGVNITYKILYNDAVAMTGGQPVDGGLSVPQITRQLAAEGVKR 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 557 IALVSDEPDKYPSREDFAPITTFHHRRDLDSVQRELREFKGVSVIIYDQTCATEKRRRRKRGTMPDLEKRALINPAVCEG 636
Cdd:PRK09193 568 IVVVTDEPEKYDGVARLAPGVTVHHRDELDAVQRELREIPGVTVLIYDQTCAAEKRRRRKRGTLPDPAKRVFINEAVCEG 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 637 CGDCGVKSGCLSVLPKETAQGRKREIDQSACNKDFSCVEGFCPSFVTVHGGKLRKPALPKQV-EAFARLPEPVLPSLDRP 715
Cdd:PRK09193 648 CGDCSVKSNCLSVEPVETEFGRKRRIDQSSCNKDFSCLKGFCPSFVTVEGGKLRKPAAAAADaAALPPLPEPALPALDGP 727
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 716 FNILLPGVGGTGVTTVGAMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQEDLFAVRIAAGEAHLLLGCDLLVA 795
Cdd:PRK09193 728 YNILVTGVGGTGVVTIGALLGMAAHLEGKGVSVLDMTGLAQKGGAVVSHVRIAARPEDIHATRIAAGEADLVIGCDLVVA 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 796 AGPDAIAKLDSKISHAVVNSQQTPTAEFTRNPDAVFPAEAMKQTIIEAVGAAKTHFVEATSLATRLMGDSIASNLFMLGY 875
Cdd:PRK09193 808 AGPEALSRMRPGRTRAVVNTHETPTADFVRNPDWRFPGAALEAALRAAVGGDRVDFIDATRLATALLGDSIYTNMFLLGY 887
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 876 AFQLGLIPLTSAAIEKAIELNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSmdLDQRIQSNVDALKQYQNA 955
Cdd:PRK09193 888 AWQKGLLPLSAAAIERAIELNGVAVEMNLAAFRWGRRAAHDPAAVAALAAAAPPAPAPPS--LDELIARRVAFLTAYQNA 965
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 956 AYAKRYLALVQRVRDSESRAFPGQQPtLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLAPSWL 1035
Cdd:PRK09193 966 AYAARYRALVERVRAAERALGPGSEA-LTEAVARNLFKLMAYKDEYEVARLYTDPAFLAKLAAQFEGDYKLTFHLAPPLL 1044
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1036 AKRDPHnGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTALSLAR 1115
Cdd:PRK09193 1045 AKKDPR-GRPRKRAFGPWMMPAFRLLAKLKGLRGTALDPFGYTEERRTERALIAEYEALVDELLARLTADNLALAVELAS 1123
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|..
gi 2205733266 1116 LPERIRGYGYIKESAMKAAAVQADILRKSLENGEVAAPKLYE 1157
Cdd:PRK09193 1124 LPDEIRGYGHVKEANVAAARARWAELLAQLRAPEAAQARAAA 1165
|
|
| DUF6537 |
pfam20169 |
Family of unknown function (DUF6537); This entry represents a presumed domain that is found ... |
952-1139 |
6.45e-75 |
|
Family of unknown function (DUF6537); This entry represents a presumed domain that is found associated with a variety of enzyme domains. The function of this domain is unknown.
Pssm-ID: 466320 [Multi-domain] Cd Length: 201 Bit Score: 246.41 E-value: 6.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 952 YQNAAYAKRYLALVQRVRDSESRAFPGqqPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLA 1031
Cdd:pfam20169 15 YQDAAYAARYLDRVARVRAAEGAAAAG--PGLTRAVARYLAKLMAYKDEYEVARLKTDGSFARRVREEFGDIYRLTFHLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1032 PSWLAKRDPHNGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTAL 1111
Cdd:pfam20169 93 PPLLARRDPATGRPRKRRFGPWMFRALRLLARLKRLRGTPLDPFGYSLRRREERALIERYLAMIERLLPRLSAANYALAV 172
|
170 180
....*....|....*....|....*...
gi 2205733266 1112 SLARLPERIRGYGYIKESAMKAAAVQAD 1139
Cdd:pfam20169 173 ELARLPELIRGYGDVKERGLAKARARLA 200
|
|
| TPP_IOR_alpha |
cd02008 |
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of ... |
426-607 |
6.48e-54 |
|
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the transamination of aromatic amino acids, to the corresponding aryl acetyl-CoA.
Pssm-ID: 238966 [Multi-domain] Cd Length: 178 Bit Score: 185.94 E-value: 6.48e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 426 QRTPHFCSGCPHNTSTKVPEG-----SRALAGIGCHYMTIWMDRE-TDTFTQMGGEGVTWIGQAPFTETPHVFQNLGDGT 499
Cdd:cd02008 1 PRPPGLCPGCPHRPSFYALRKafkkdSIVSGDIGCYTLGALPPLNaIDTCTCMGASIGVAIGMAKASEDKKVVAVIGDST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 500 YFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLR-------VDQLSRQVFNEGVLRIALVSDEpdkypsred 572
Cdd:cd02008 81 FFHSGILGLINAVYNKANITVVILDNRTTAMTGGQPHPGTGKtltepttVIDIEALVRAIGVKRVVVVDPY--------- 151
|
170 180 190
....*....|....*....|....*....|....*...
gi 2205733266 573 fapittfhhrrDLDSVQRELRE---FKGVSVIIYDQTC 607
Cdd:cd02008 152 -----------DLKAIREELKEalaVPGVSVIIAKRPC 178
|
|
| PorG |
COG1014 |
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma ... |
733-1142 |
4.41e-32 |
|
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 440638 [Multi-domain] Cd Length: 424 Bit Score: 130.58 E-value: 4.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 733 AMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQedLFAVRIaaGEAHLLLGCDLLVAAGPDAIAKLDSKIshaV 812
Cdd:COG1014 22 KILAKAAMREGYYVQGYPSYGSEQRGGPVVSHVRISDEP--IRSPLI--DEADVLIALDPEELDRVLDGLKPGGVL---I 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 813 VNSQQTPTaEFTRNPdavfpaeamKQTIIEAvgAAKTHFVEATSLATRLMGDSIASNLFMLGYAFQlgLIPLTSAAIEKA 892
Cdd:COG1014 95 VNSSLVPP-EVWRLP---------QEALERK--DIRVYVIDATKIAKELLGNARVANTVMLGALAA--LLGLPLEALEEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 893 IE-----LNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSMDLdqriqsnvDALKQYQNAAYAKRYLALVQR 967
Cdd:COG1014 161 IEetfgkKGEKVVELNLKAFEAGYEAAKEVFALAAAPAPLVLLAGNAAAAL--------GAAAGGAAFAAAYPITPSTSL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 968 VRDSESRAFPGQQPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLAPSWLAKRDPHNGLPRK 1047
Cdd:COG1014 233 IEAAAAAAAKVGGVVAEEEAAAAAAAAAAAAAAAGAAAAAAGGGGGAALATEGLGLAGMTETPVVAVAAPRPGPGTGTPT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1048 RSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTALSLARLPERIRGYGYIK 1127
Cdd:COG1014 313 EEEQGLLLLAAGGGGGEAPALALAPDTEEELLFAAAAAFALAEYAQALLLLLLLQLLVLLLTDLLLLLLDLLRRRAGLGA 392
|
410
....*....|....*
gi 2205733266 1128 ESAMKAAAVQADILR 1142
Cdd:COG1014 393 EEAEARRKLLAAEGR 407
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09193 |
PRK09193 |
indolepyruvate ferredoxin oxidoreductase; Validated |
1-1157 |
0e+00 |
|
indolepyruvate ferredoxin oxidoreductase; Validated
Pssm-ID: 236404 [Multi-domain] Cd Length: 1165 Bit Score: 2120.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1 MSLADIRLDDKYRLATGNLYLTGTQALTRLPMLQKQRDEARGLNTAGFISGYRGSPLGNLDKSLWDAKDYLQQNAIHFQP 80
Cdd:PRK09193 8 MALADVTLDDKYTLERGRVFLTGTQALVRLPLLQRERDRAAGLNTAGFVSGYRGSPLGGLDQELWRAKKHLAAHDIVFQP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 81 GINEELAATAVWGSQQVNLFPHGKYDGVFALWYGKGPGVDRCGDVFKHGNSAGVAANGGVLILAGDDHGCKSSTIAHQSE 160
Cdd:PRK09193 88 GLNEDLAATAVWGSQQVNLFPGAKYDGVFGMWYGKGPGVDRSGDVFRHANAAGTSPHGGVLALAGDDHAAKSSTLPHQSE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 161 HAFIASMIPVLNPSNVQEILDYGIIGWELSRYSGCWVAMKTIAENVDSSAVVEVDPLRIKTRIPDDFDLPEGGLHIRWPD 240
Cdd:PRK09193 168 HAFKAAGMPVLFPANVQEILDYGLHGWAMSRYSGLWVGMKTVTDVVESSASVDVDPDRVQIVLPEDFEMPPGGLNIRWPD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 241 PPLAQEARLNTYKIYAARAFARANQLNKVVIDSAQPRLGIITTGKSYLDVRQALEELGIDQELCEKVGIRVLKVGMSWPL 320
Cdd:PRK09193 248 PPLEQEARLLDYKLYAALAYARANKLDRVVIDSPNARLGIVAAGKAYLDVRQALRDLGLDEETAARLGIRLYKVGMVWPL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 321 EPVSVHDFAEGLDEILVVEEKRSVIEDQLTGQLYNWPVERRPVVVGEFDEQGRSLLPNLSELTPAMIARVIAKRLAPF-- 398
Cdd:PRK09193 328 EPQGVRAFAEGLDEILVVEEKRQIIEYQLKEELYNWPDDVRPRVIGKFDPQGNWLLPAHGELSPAIIAKAIARRLLKLel 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 399 --YSSPQIEARLQFLSDKEQALQAPLFNTQRTPHFCSGCPHNTSTKVPEGSRALAGIGCHYMTIWMDRETDTFTQMGGEG 476
Cdd:PRK09193 408 pgDVRARIAARLAVLEAKEAALALPRVTAARTPYFCSGCPHNTSTRVPEGSRALAGIGCHYMATWMDRNTSTFTQMGGEG 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 477 VTWIGQAPFTETPHVFQNLGDGTYFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLRVDQLSRQVFNEGVLR 556
Cdd:PRK09193 488 VPWIGQAPFTDEKHVFQNLGDGTYFHSGLLAIRAAVAAGVNITYKILYNDAVAMTGGQPVDGGLSVPQITRQLAAEGVKR 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 557 IALVSDEPDKYPSREDFAPITTFHHRRDLDSVQRELREFKGVSVIIYDQTCATEKRRRRKRGTMPDLEKRALINPAVCEG 636
Cdd:PRK09193 568 IVVVTDEPEKYDGVARLAPGVTVHHRDELDAVQRELREIPGVTVLIYDQTCAAEKRRRRKRGTLPDPAKRVFINEAVCEG 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 637 CGDCGVKSGCLSVLPKETAQGRKREIDQSACNKDFSCVEGFCPSFVTVHGGKLRKPALPKQV-EAFARLPEPVLPSLDRP 715
Cdd:PRK09193 648 CGDCSVKSNCLSVEPVETEFGRKRRIDQSSCNKDFSCLKGFCPSFVTVEGGKLRKPAAAAADaAALPPLPEPALPALDGP 727
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 716 FNILLPGVGGTGVTTVGAMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQEDLFAVRIAAGEAHLLLGCDLLVA 795
Cdd:PRK09193 728 YNILVTGVGGTGVVTIGALLGMAAHLEGKGVSVLDMTGLAQKGGAVVSHVRIAARPEDIHATRIAAGEADLVIGCDLVVA 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 796 AGPDAIAKLDSKISHAVVNSQQTPTAEFTRNPDAVFPAEAMKQTIIEAVGAAKTHFVEATSLATRLMGDSIASNLFMLGY 875
Cdd:PRK09193 808 AGPEALSRMRPGRTRAVVNTHETPTADFVRNPDWRFPGAALEAALRAAVGGDRVDFIDATRLATALLGDSIYTNMFLLGY 887
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 876 AFQLGLIPLTSAAIEKAIELNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSmdLDQRIQSNVDALKQYQNA 955
Cdd:PRK09193 888 AWQKGLLPLSAAAIERAIELNGVAVEMNLAAFRWGRRAAHDPAAVAALAAAAPPAPAPPS--LDELIARRVAFLTAYQNA 965
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 956 AYAKRYLALVQRVRDSESRAFPGQQPtLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLAPSWL 1035
Cdd:PRK09193 966 AYAARYRALVERVRAAERALGPGSEA-LTEAVARNLFKLMAYKDEYEVARLYTDPAFLAKLAAQFEGDYKLTFHLAPPLL 1044
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1036 AKRDPHnGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTALSLAR 1115
Cdd:PRK09193 1045 AKKDPR-GRPRKRAFGPWMMPAFRLLAKLKGLRGTALDPFGYTEERRTERALIAEYEALVDELLARLTADNLALAVELAS 1123
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|..
gi 2205733266 1116 LPERIRGYGYIKESAMKAAAVQADILRKSLENGEVAAPKLYE 1157
Cdd:PRK09193 1124 LPDEIRGYGHVKEANVAAARARWAELLAQLRAPEAAQARAAA 1165
|
|
| PRK13030 |
PRK13030 |
indolepyruvate ferredoxin oxidoreductase family protein; |
3-1153 |
0e+00 |
|
indolepyruvate ferredoxin oxidoreductase family protein;
Pssm-ID: 237279 [Multi-domain] Cd Length: 1159 Bit Score: 1737.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 3 LADIRLDDKYRLATGNLYLTGTQALTRLPMLQKQRDEARGLNTAGFISGYRGSPLGNLDKSLWDAKDYLQQNAIHFQPGI 82
Cdd:PRK13030 2 LSDYRLDDRYTATRGRIFLTGTQALVRLLLMQRRRDRARGLNTAGFVSGYRGSPLGGVDQALWKAKKLLDASDIRFLPGI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 83 NEELAATAVWGSQQVNLFPHGKYDGVFALWYGKGPGVDRCGDVFKHGNSAGVAANGGVLILAGDDHGCKSSTIAHQSEHA 162
Cdd:PRK13030 82 NEELAATAVLGTQQVEADPERTVDGVFAMWYGKGPGVDRAGDALKHGNAYGSSPHGGVLVVAGDDHGCVSSSMPHQSDFA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 163 FIASMIPVLNPSNVQEILDYGIIGWELSRYSGCWVAMKTIAENVDSSAVVEVDPLRIKTRIPDDFDLPEGGLHIRWPDPP 242
Cdd:PRK13030 162 LIAWHMPVLNPANVQEYLDFGLYGWALSRYSGAWVGFKAISETVESGSTVDLDPDRTRWPAPEDFTPPAGGLHNRWPDLP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 243 LAQEARLNTYKIYAARAFARANQLNKVVIDSAQPRLGIITTGKSYLDVRQALEELGIDQELCEKVGIRVLKVGMSWPLEP 322
Cdd:PRK13030 242 SLAIEARLAAKLPAVRAFARANSIDRWVAPSPDARVGIVTCGKAHLDLMEALRRLGLDDADLRAAGIRIYKVGLSWPLEP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 323 VSVHDFAEGLDEILVVEEKRSVIEDQLTGQLYNWPVERRPVVVGEFDEQGRSLLPNLSELTPAMIARVIAKRLAPFYSSP 402
Cdd:PRK13030 322 TRLREFADGLEEILVIEEKRPVIEQQIKDYLYNRPGGARPRVVGKHDEDGAPLLSELGELRPSLIAPVLAARLARHKPAL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 403 QIEARLQFLSDKE-QALQAPLfnTQRTPHFCSGCPHNTSTKVPEGSRALAGIGCHYMTIWMDRETDTFTQMGGEGVTWIG 481
Cdd:PRK13030 402 DRRARVVDLVAPQiLSNEADA--VVRTPYFCSGCPHNTSTKVPEGSIAQAGIGCHFMASWMDRDTTGLTQMGGEGVDWIG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 482 QAPFTETPHVFQNLGDGTYFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLRVDQLSRQVFNEGVLRIALVS 561
Cdd:PRK13030 480 HAPFTETKHVFQNLGDGTYFHSGSLAIRQAVAAGANITYKILYNDAVAMTGGQPVDGSISVPQIARQVEAEGVSRIVVVS 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 562 DEPDKYpSREDFAPITTFHHRRDLDSVQRELREFKGVSVIIYDQTCATEKRRRRKRGTMPDLEKRALINPAVCEGCGDCG 641
Cdd:PRK13030 560 DEPEKY-RGHHLPAGVTVHHRDELDAVQRELRETPGVTVLIYDQTCAAEKRRRRKRGEFPDPDRRLFINEAVCEGCGDCG 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 642 VKSGCLSVLPKETAQGRKREIDQSACNKDFSCVEGFCPSFVTVHGGKLRKPALPK-----QVEAFARLPEPVLPSLDRPF 716
Cdd:PRK13030 639 VQSNCLSVEPVETPFGRKRRIDQSSCNKDFSCVNGFCPSFVTVEGATLRKAAGAAfdaaaLAARVDALPLPATPADAAPY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 717 NILLPGVGGTGVTTVGAMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQEDLFAVRIAAGEAHLLLGCDLLVAA 796
Cdd:PRK13030 719 DLLVTGVGGTGVVTVGALLAMAAHLEGKSASVLDFTGLAQKGGAVLSHVRIAASPEWLHQVRIDTQQADLLLACDMVVGA 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 797 GPDAIAKLDSKISHAVVNSQQTPTAEFTRNPDAVFPAEAMKQTIIEAVGAAKTHFVEATSLATRLMGDSIASNLFMLGYA 876
Cdd:PRK13030 799 SPDALQTVRHGRTRAVVNTHEIPTADFVRNPDANLPADALLDKMRHAAGDERLASLDAQALAEKLLGDAIGANILMLGYA 878
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 877 FQLGLIPLTSAAIEKAIELNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSMD-LDQRIQSNVDALKQYQNA 955
Cdd:PRK13030 879 WQLGLVPLSLAALMRAIELNGVAVEMNLLAFRWGRLAAADPAALAAAWAAAHPVAAPAAPEtLDRLVARREAELTAYQDA 958
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 956 AYAKRYLALVQRVRDSEsrAFPGQQPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLAPSWL 1035
Cdd:PRK13030 959 AYAARYRALVARVRAAE--QALAGDEALTEAVARTLYKLMAYKDEYEVARLYTDPAFRAALEAQFEGDYRLKFHLAPPLL 1036
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1036 AKRDPHNGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTALSLAR 1115
Cdd:PRK13030 1037 AKADPRTGRPRKRRFGPWMWPAFRLLARLKGLRGTWLDPFGRTAERRMERALIDDYEATLERLLAALTAGNLDAAAALAE 1116
|
1130 1140 1150
....*....|....*....|....*....|....*...
gi 2205733266 1116 LPERIRGYGYIKESAMKAAAVQADILRKSLenGEVAAP 1153
Cdd:PRK13030 1117 LPDEVRGYGHVKLANLARVKAEEAELLARL--GIDAAT 1152
|
|
| PRK13029 |
PRK13029 |
indolepyruvate ferredoxin oxidoreductase family protein; |
1-1154 |
0e+00 |
|
indolepyruvate ferredoxin oxidoreductase family protein;
Pssm-ID: 237278 [Multi-domain] Cd Length: 1186 Bit Score: 1649.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1 MSLADIRLDDKYRLATGNLYLTGTQALTRLPMLQKQRDEARGLNTAGFISGYRGSPLGNLDKSLWDAKDYLQQNAIHFQP 80
Cdd:PRK13029 11 MALRAVSLDDKYTLERGRIYISGTQALVRLPLLQRARDRRAGLNTAGFISGYRGSPLGALDQALWKAKKHLAAADVVFQP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 81 GINEELAATAVWGSQQVNLFPHGKYDGVFALWYGKGPGVDRCGDVFKHGNSAGVAANGGVLILAGDDHGCKSSTIAHQSE 160
Cdd:PRK13029 91 GVNEELAATAVWGSQQLELDPGAKRDGVFGMWYGKGPGVDRSGDALRHANLAGTSPLGGVLVLAGDDHGAKSSSVAHQSD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 161 HAFIASMIPVLNPSNVQEILDYGIIGWELSRYSGCWVAMKTIAENVDSSAVVEVDPLRIKTRIPDDFDLPEGGLHIRWPD 240
Cdd:PRK13029 171 HTFIAWGIPVLYPASVQDYLDYGLHGWAMSRYSGLWVGMKCVTEVVESTASVDLDPDRVDIVLPDDFVLPPGGLHIRWPD 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 241 PPLAQEARLNTYKIYAARAFARANQLNKVVIDSAQPRLGIITTGKSYLDVRQALEELGIDQELCEKVGIRVLKVGMSWPL 320
Cdd:PRK13029 251 DPLAQEERMLEFKWYAALAYVRANRLNRLVIDGPNPRLGIIAAGKAYLDVRQALRDLGLDDATCAALGIRLLKVGCVWPL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 321 EPVSVHDFAEGLDEILVVEEKRSVIEDQLTGQLYNWPVERRPVVVGEFD-----------EQGRSLLPNLSELTPAMIAR 389
Cdd:PRK13029 331 DPQSVREFAQGLEEVLVVEEKRAVIEYQLKEELYNWREDVRPAIFGKFDhrdgaggewsvPAGRWLLPAHAELSPALIAK 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 390 VIAKRLAPFYSSPQ----IEARLQFLSDKEQALQAPLFNTQRTPHFCSGCPHNTSTKVPEGSRALAGIGCHYMTIWMDRE 465
Cdd:PRK13029 411 AIARRLAALGLPADvaarMDARVADIEAKERAAAQPRLLTERKPWFCSGCPHNTSTRVPEGSRALAGIGCHYMAMWMDRS 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 466 TDTFTQMGGEGVTWIGQAPFTETPHVFQNLGDGTYFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLRVDQL 545
Cdd:PRK13029 491 TEGFSQMGGEGVAWIGQMPFSRRRHVFQNLGDGTYFHSGLLAIRQAIAAGVNITYKILYNDAVAMTGGQPVDGVLTVPQI 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 546 SRQVFNEGVLRIALVSDEPDKYPSREDFAPITTFHHRRDLDSVQRELREFKGVSVIIYDQTCATEKRRRRKRGTMPDLEK 625
Cdd:PRK13029 571 ARQVHAEGVRRIVVVTDEPGKYRGVARLPAGVTVHHRDELDAVQRELREVPGVSVLIYDQTCATEKRRRRKRGTYPDPAR 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 626 RALINPAVCEGCGDCGVKSGCLSVLPKETAQGRKREIDQSACNKDFSCVEGFCPSFVTVHGGKLRKPALPKQVEA----F 701
Cdd:PRK13029 651 RVFINELVCEGCGDCSVQSNCLAVQPVETEFGRKRKINQSSCNKDFSCVKGFCPSFVTVEGAQLKKPSDAALGRAalaaV 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 702 ARLPEPVLPSLDRPFNILLPGVGGTGVTTVGAMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQEDLFAVRIAA 781
Cdd:PRK13029 731 AALPLPTLALLDRPYGILVTGIGGTGVVTIGGVLGMAAHLEGKGVSVLDMAGLAQKGGAVLSHIQIAATPAALHATRIDT 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 782 GEAHLLLGCDLLVAAGPDAIAKLDSKISHAVVNSQQTPTAEFTRNPDAVFPAEAMKQTIIEAVGAAKTHFVEATSLATRL 861
Cdd:PRK13029 811 GEADLVIACDLVVAASGEALAAMRPGRTRAAANSHETPTAAFVRNPDWSFPVDQTVALLRDSIGADQCAFFDANALALAL 890
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 862 MGDSIASNLFMLGYAFQLGLIPLTSAAIEKAIELNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSM----D 937
Cdd:PRK13029 891 LGDSIYANPLLLGFAWQKGWVPLSLDALERAIELNGVAVDSNRAAFEWGRLAAHDGAAAARADGGEAAARQAIVFqrpeS 970
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 938 LDQRIQSNVDALKQYQNAAYAKRYLALVQRVRDSESRAFPGQQPtLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQ 1017
Cdd:PRK13029 971 LDDLIESRAAFLTDYQNAAYAARYRARVDRVRAAEAVVGGGSAR-LTEAVARNLFKLMAYKDEYEVARLYTDPAFLDQLA 1049
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1018 AQFEGDYRLEFHLAPSWLAKRDPHnGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVEL 1097
Cdd:PRK13029 1050 AEFEGEPRLSFHLAPPLFARRDER-GHLVKVRYGPWMLPAFRVLARLKGLRGTAFDVFGYTEERRAERALIAEYRALLDE 1128
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*..
gi 2205733266 1098 ILQHLQAQNRHTALSLARLPERIRGYGYIKESAMKAAAVQADILRKSLENGEVAAPK 1154
Cdd:PRK13029 1129 LCPSLTAGRLDIALELARLPEDIRGYGHVKARNVAAAAKRRERLLARYRQPSTGRPL 1185
|
|
| DUF6537 |
pfam20169 |
Family of unknown function (DUF6537); This entry represents a presumed domain that is found ... |
952-1139 |
6.45e-75 |
|
Family of unknown function (DUF6537); This entry represents a presumed domain that is found associated with a variety of enzyme domains. The function of this domain is unknown.
Pssm-ID: 466320 [Multi-domain] Cd Length: 201 Bit Score: 246.41 E-value: 6.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 952 YQNAAYAKRYLALVQRVRDSESRAFPGqqPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLA 1031
Cdd:pfam20169 15 YQDAAYAARYLDRVARVRAAEGAAAAG--PGLTRAVARYLAKLMAYKDEYEVARLKTDGSFARRVREEFGDIYRLTFHLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1032 PSWLAKRDPHNGLPRKRSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTAL 1111
Cdd:pfam20169 93 PPLLARRDPATGRPRKRRFGPWMFRALRLLARLKRLRGTPLDPFGYSLRRREERALIERYLAMIERLLPRLSAANYALAV 172
|
170 180
....*....|....*....|....*...
gi 2205733266 1112 SLARLPERIRGYGYIKESAMKAAAVQAD 1139
Cdd:pfam20169 173 ELARLPELIRGYGDVKERGLAKARARLA 200
|
|
| TPP_IOR_alpha |
cd02008 |
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of ... |
426-607 |
6.48e-54 |
|
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the transamination of aromatic amino acids, to the corresponding aryl acetyl-CoA.
Pssm-ID: 238966 [Multi-domain] Cd Length: 178 Bit Score: 185.94 E-value: 6.48e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 426 QRTPHFCSGCPHNTSTKVPEG-----SRALAGIGCHYMTIWMDRE-TDTFTQMGGEGVTWIGQAPFTETPHVFQNLGDGT 499
Cdd:cd02008 1 PRPPGLCPGCPHRPSFYALRKafkkdSIVSGDIGCYTLGALPPLNaIDTCTCMGASIGVAIGMAKASEDKKVVAVIGDST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 500 YFHSGHLALRAAVASKVNITYKILYNDAVAMTGGQPIDGVLR-------VDQLSRQVFNEGVLRIALVSDEpdkypsred 572
Cdd:cd02008 81 FFHSGILGLINAVYNKANITVVILDNRTTAMTGGQPHPGTGKtltepttVIDIEALVRAIGVKRVVVVDPY--------- 151
|
170 180 190
....*....|....*....|....*....|....*...
gi 2205733266 573 fapittfhhrrDLDSVQRELRE---FKGVSVIIYDQTC 607
Cdd:cd02008 152 -----------DLKAIREELKEalaVPGVSVIIAKRPC 178
|
|
| PorG |
COG1014 |
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma ... |
733-1142 |
4.41e-32 |
|
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 440638 [Multi-domain] Cd Length: 424 Bit Score: 130.58 E-value: 4.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 733 AMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQedLFAVRIaaGEAHLLLGCDLLVAAGPDAIAKLDSKIshaV 812
Cdd:COG1014 22 KILAKAAMREGYYVQGYPSYGSEQRGGPVVSHVRISDEP--IRSPLI--DEADVLIALDPEELDRVLDGLKPGGVL---I 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 813 VNSQQTPTaEFTRNPdavfpaeamKQTIIEAvgAAKTHFVEATSLATRLMGDSIASNLFMLGYAFQlgLIPLTSAAIEKA 892
Cdd:COG1014 95 VNSSLVPP-EVWRLP---------QEALERK--DIRVYVIDATKIAKELLGNARVANTVMLGALAA--LLGLPLEALEEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 893 IE-----LNGVAVNLNQQAFLWGRRTAHDPAAVEAFVNPQDKVSEPQSMDLdqriqsnvDALKQYQNAAYAKRYLALVQR 967
Cdd:COG1014 161 IEetfgkKGEKVVELNLKAFEAGYEAAKEVFALAAAPAPLVLLAGNAAAAL--------GAAAGGAAFAAAYPITPSTSL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 968 VRDSESRAFPGQQPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQFEGDYRLEFHLAPSWLAKRDPHNGLPRK 1047
Cdd:COG1014 233 IEAAAAAAAKVGGVVAEEEAAAAAAAAAAAAAAAGAAAAAAGGGGGAALATEGLGLAGMTETPVVAVAAPRPGPGTGTPT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1048 RSFGPWMLRAFDVLAKFKFLRGTALDPFGRSLERQQERALIDRYVSDVELILQHLQAQNRHTALSLARLPERIRGYGYIK 1127
Cdd:COG1014 313 EEEQGLLLLAAGGGGGEAPALALAPDTEEELLFAAAAAFALAEYAQALLLLLLLQLLVLLLTDLLLLLLDLLRRRAGLGA 392
|
410
....*....|....*
gi 2205733266 1128 ESAMKAAAVQADILR 1142
Cdd:COG1014 393 EEAEARRKLLAAEGR 407
|
|
| TPP_PYR_PFOR_IOR-alpha_like |
cd07034 |
Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ... |
40-200 |
6.59e-25 |
|
Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain, of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit (IOR-alpha), and related proteins, subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzyme Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit. This subfamily includes proteins characterized as pyruvate NADP+ oxidoreductase (PNO). PFOR and PNO catalyze the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. The facultative anaerobic mitochondrion of the photosynthetic protist Euglena gracilis oxidizes pyruvate with PNO. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate.
Pssm-ID: 132917 [Multi-domain] Cd Length: 160 Bit Score: 102.19 E-value: 6.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 40 ARGLNTAG--FISGYRGSPLGNLDKSLWDAKDyLQQNAIHFQPGiNEELAATAVWGSQQVnlfphgkydGVFALWYGKGP 117
Cdd:cd07034 6 ARGALAAGvdVVAAYPITPSTEIAETLAKAVL-GELGGVVVQAE-SEHAAAEAAIGASAA---------GARAMTATSGP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 118 GVDRCGDVFKHGNSAGVaanGGVLILAGDDHGCKSSTIAHQSEHAFIASM---IPVLNPSNVQEILDYGIIGWELSRYSG 194
Cdd:cd07034 75 GLNLMAEALYLAAGAEL---PLVIVVAQRPGPSTGLPKPDQSDLMAARYGghpWPVLAPSSVQEAFDLALEAFELAEKYR 151
|
....*.
gi 2205733266 195 cWVAMK 200
Cdd:cd07034 152 -LPVIV 156
|
|
| POR |
pfam01558 |
Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large ... |
734-912 |
1.89e-15 |
|
Pyruvate ferredoxin/flavodoxin oxidoreductase; This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyzes the final step in the fermentation of carbohydrates in anaerobic microorganizms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited.
Pssm-ID: 426323 [Multi-domain] Cd Length: 172 Bit Score: 75.42 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 734 MLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAARQEDLfavRIAAGEAHLLLGCDLLVAAgpDAIAKL--DSKIsha 811
Cdd:pfam01558 11 ILAKAAARAGYYVQATPEYGSEIRGGPVVSHVRISDEPIVP---AIPVGEADLLVALDPETLD--RHLDGLkpGGII--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 812 VVNSqqtptaeftrnpdAVFPAEAMKQTIIEAVGAAKTHFVEATSLATRLMGDSIASNLFMLGYAFQLGLIPLTS--AAI 889
Cdd:pfam01558 83 IYNS-------------SEVPPELLEKDLPAYPRLARVYGVPATEIAKEAGGNSRAANTVMLGALAALLGLPLEAleEAI 149
|
170 180
....*....|....*....|...
gi 2205733266 890 EKAIELNGVAVNLNQQAFLWGRR 912
Cdd:pfam01558 150 KKRFPGKAKVIELNLKAFRAGYE 172
|
|
| PRK06274 |
PRK06274 |
indolepyruvate oxidoreductase subunit beta; |
734-914 |
3.29e-13 |
|
indolepyruvate oxidoreductase subunit beta;
Pssm-ID: 235765 [Multi-domain] Cd Length: 197 Bit Score: 69.69 E-value: 3.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 734 MLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAarqEDLFAVRIAAGEAHLLLGcdlLVAAGPDAIAKLDSKISHAVV 813
Cdd:PRK06274 21 ILANAAMNEGFHVRTAETLGMSQREGSVISHLRFG---DEISSPLIPEGQADLLLA---LEPAEVARNLHFLKKGGKIIV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 814 NSQQTPTAefTRNPDAVFPAEAMKQTIIEAVGaaKTHFVEATSLAtRLMGDSIASNLFMLGYAFQLGLIPLTSAAIEKAI 893
Cdd:PRK06274 95 NAYAIHPA--TTVGSEKYDPEKEIKFAKEKIC--DVICIDFTKLA-DEIGNPRSLNVIMLGAAFGAGLLPLSKESVLETI 169
|
170 180
....*....|....*....|...
gi 2205733266 894 E--LNGVAVNLNQQAFLWGRRTA 914
Cdd:PRK06274 170 EaeLPEKLREINLAAFELGIELI 192
|
|
| PRK06853 |
PRK06853 |
indolepyruvate oxidoreductase subunit beta; Reviewed |
716-918 |
1.09e-12 |
|
indolepyruvate oxidoreductase subunit beta; Reviewed
Pssm-ID: 180732 [Multi-domain] Cd Length: 197 Bit Score: 67.97 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 716 FNILLPGVGGTGVTTVGAMLGYAANLEGKGCSVLDQAGLAQKFGPVVSHIRIAarqEDLFAVRIAAGEAHLLLGCDLLVA 795
Cdd:PRK06853 4 TNILIVGVGGQGILLASKILGEAALAAGYDVKVSEVHGMSQRGGSVVSHVRFG---DEVYSPLIPEGKADLLLAFEPLEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 796 A------GPDAIakldskishAVVNSQQ----TPTAEFTRNPDAVFPAEAMKQTIIEAVgaakthFVEATSLATRLmGDS 865
Cdd:PRK06853 81 LrylpylKKGGK---------VVVNTQPivpvPVSLGLAKYPEDEEILEELKKLGIKVY------VIDAEKIAKEA-GNI 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2205733266 866 IASNLFMLGYAFQlgLIPLTSAAIEKAIELNGV--AVNLNQQAFLWGRRTAHDPA 918
Cdd:PRK06853 145 KAANVVLLGALAK--FLPIDEETLEEAIKERVPpkFVEVNLKAFEAGREAAEKLA 197
|
|
| IorA |
COG4231 |
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ... |
626-679 |
1.94e-10 |
|
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];
Pssm-ID: 443375 [Multi-domain] Cd Length: 76 Bit Score: 58.13 E-value: 1.94e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2205733266 626 RALINPAVCEGCGDCgVKSgClsvlPKET--AQGRKREIDQSACNKDFSCVEgFCP 679
Cdd:COG4231 16 RYVIDEDKCTGCGAC-VKV-C----PADAieEGDGKAVIDPDLCIGCGSCVQ-VCP 64
|
|
| PRK08312 |
PRK08312 |
indolepyruvate oxidoreductase subunit beta family protein; |
838-1124 |
1.02e-09 |
|
indolepyruvate oxidoreductase subunit beta family protein;
Pssm-ID: 236234 [Multi-domain] Cd Length: 510 Bit Score: 62.31 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 838 QTIIEAVGAAKTHFV----EATSLATRLMgdsIASNLF-MLGYAfqlGLIPLTSAAIEKAIELNGVAVNLNQQAFLWGRR 912
Cdd:PRK08312 137 AALLDAARAAAKRFIafdmEALAEAAGSV---ISASLFgALAGS---GALPFAREQFEAVIRASGKGVKASLRAFAAGFA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 913 TAHD------PAAVEAFVNPQDKVSEPQSMDLDQRIQSNVDA------------LKQYQNAAYAKRYLALVQRVRDSESR 974
Cdd:PRK08312 211 AAQQggaappPPAAAAPTAPRPRPPALAARALLARVEAEFPAaaramlleglrrLVDYQDAAYAAEYLDRLAALAAADGG 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 975 afPGQQPTLTEAVAFNYFKLLAYKDEYEVARLYSNGDFTRQLQAQF---EGDY---------RLE--FHLAPSWLAKRdp 1040
Cdd:PRK08312 291 --GARDFALTREAARHLALWMSYDDTIRVADLKTRASRFERVRDEVgakPGQIvqvtefmhpRLEeiCGTLPAGLGRW-- 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2205733266 1041 hngLPRKRSFGPWMLRAFD--------VLAKFKFLRGTA-LDPFGRSLER-QQERALIDRYVSDVELILQHlqaqNRHTA 1110
Cdd:PRK08312 367 ---LEASPRLRAWLDRRTRrgrrvrtsSLRGFLLLYLLAgLRRLRRRSLRhAEEQAHIERWLAAALAAARE----DPALA 439
|
330
....*....|....
gi 2205733266 1111 LSLARLPERIRGYG 1124
Cdd:PRK08312 440 VEILQCQRLVKGYS 453
|
|
| Fer4_10 |
pfam13237 |
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ... |
626-679 |
9.86e-03 |
|
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.
Pssm-ID: 404174 [Multi-domain] Cd Length: 56 Bit Score: 35.69 E-value: 9.86e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2205733266 626 RALINPAVCEGCGDCgvKSGC-----LSVLPKETAQGRKREIDQSACNKDFSCVEgFCP 679
Cdd:pfam13237 1 KVVIDPDKCIGCGRC--TAACpagltRVGAIVERLEGEAVRIGVWKCIGCGACVE-ACP 56
|
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