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Conserved domains on  [gi|2208669981|ref|WP_241483957|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Rhodococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442293)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Gene Ontology:  GO:0003700
PubMed:  34327903|24006471|15808743
SCOP:  8087036

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
25-62 8.52e-08

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.63  E-value: 8.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2208669981  25 FGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLA 62
Cdd:pfam00440   9 FAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEA 46
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-151 8.49e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669981   8 RNSARTRADLLAAAAELFGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLATLP--TDDTGPDLADIADPSRIEDT 85
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLErlLEELLAALEEALAAEDPRER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2208669981  86 IRRVAR------LGPGPVLHAVVGKHDDPDVQATAAERVDKRLTVGLENRLRAAGV---GNPRLRAQLAVAALSG 151
Cdd:COG1309    82 LRALLRayleflAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLladVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
25-62 8.52e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.63  E-value: 8.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2208669981  25 FGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLA 62
Cdd:pfam00440   9 FAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEA 46
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-151 8.49e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669981   8 RNSARTRADLLAAAAELFGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLATLP--TDDTGPDLADIADPSRIEDT 85
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLErlLEELLAALEEALAAEDPRER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2208669981  86 IRRVAR------LGPGPVLHAVVGKHDDPDVQATAAERVDKRLTVGLENRLRAAGV---GNPRLRAQLAVAALSG 151
Cdd:COG1309    82 LRALLRayleflAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLladVDPDALARALLALLDG 156
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 25-62 1.07e-05

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 44.27  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2208669981  25 FGQRGFQKTTlRDIGDRAGADPALVARYFGNKAALYLA 62
Cdd:PRK11552   26 FGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLA 62
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 25-63 8.67e-05

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 41.36  E-value: 8.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2208669981  25 FGQRGFQKTTLRDIGDRAGADPALVARYFGNKAAL--YLAT 63
Cdd:NF037937   12 FNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLleYLVT 52
TetR_C_16 pfam17920
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 93-184 3.21e-04

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.


Pssm-ID: 465568  Cd Length: 107  Bit Score: 38.31  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669981  93 GPGPVLHAVVGKHDDPDVQATAAERVDKRLTVGLENRLRAAgvgNPRLRAQLAVAALSGIALGRVAGTLDELATADQDDV 172
Cdd:pfam17920  19 GGGPLLALLRSAASDPEAAELLREFLAEQVLAPLAARLGGP---DAELRAALVASQLLGLALARYVLRLEPLASAPPEEL 95

                          90
                  ....*....|..
gi 2208669981 173 VALTARIVGSLL 184
Cdd:pfam17920  96 VALVGPTLQRYL 107
 
Name Accession Description Interval E-value
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
25-62 8.52e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.63  E-value: 8.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2208669981  25 FGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLA 62
Cdd:pfam00440   9 FAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEA 46
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-151 8.49e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669981   8 RNSARTRADLLAAAAELFGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLATLP--TDDTGPDLADIADPSRIEDT 85
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLErlLEELLAALEEALAAEDPRER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2208669981  86 IRRVAR------LGPGPVLHAVVGKHDDPDVQATAAERVDKRLTVGLENRLRAAGV---GNPRLRAQLAVAALSG 151
Cdd:COG1309    82 LRALLRayleflAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLladVDPDALARALLALLDG 156
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 25-62 1.07e-05

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 44.27  E-value: 1.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2208669981  25 FGQRGFQKTTlRDIGDRAGADPALVARYFGNKAALYLA 62
Cdd:PRK11552   26 FGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLA 62
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 25-63 8.67e-05

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 41.36  E-value: 8.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2208669981  25 FGQRGFQKTTLRDIGDRAGADPALVARYFGNKAAL--YLAT 63
Cdd:NF037937   12 FNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLleYLVT 52
TetR_C_16 pfam17920
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 93-184 3.21e-04

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.


Pssm-ID: 465568  Cd Length: 107  Bit Score: 38.31  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669981  93 GPGPVLHAVVGKHDDPDVQATAAERVDKRLTVGLENRLRAAgvgNPRLRAQLAVAALSGIALGRVAGTLDELATADQDDV 172
Cdd:pfam17920  19 GGGPLLALLRSAASDPEAAELLREFLAEQVLAPLAARLGGP---DAELRAALVASQLLGLALARYVLRLEPLASAPPEEL 95

                          90
                  ....*....|..
gi 2208669981 173 VALTARIVGSLL 184
Cdd:pfam17920  96 VALVGPTLQRYL 107
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 26-64 6.54e-03

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 35.97  E-value: 6.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2208669981  26 GQRGFQKTTLRDIGDRAGADPALVARYFGNKAALYLATL 64
Cdd:PRK00767   23 GEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATM 61
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 12-60 9.76e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 35.48  E-value: 9.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2208669981  12 RTRADLLAAAAELFGQRGFQKTTLRDIGDRAGADPALVARYFGNKAALY 60
Cdd:PRK09975   11 KTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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