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Conserved domains on  [gi|2208669982|ref|WP_241483958|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Nocardiaceae]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-157 2.37e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.84  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669982   7 REDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFPrGKPQLVEEATRTAGALMGSMISRGLASDGPAATLRAII 86
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFG-SKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2208669982  87 GGFRQQLEATEYTAGCPVApaalEGMNSPAALVAAGESFTSWEDTIAASLWQRGLSQDRSRGLATMAIASF 157
Cdd:COG1309    87 RAYLEFLAENPALARLLLA----EAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-157 2.37e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.84  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669982   7 REDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFPrGKPQLVEEATRTAGALMGSMISRGLASDGPAATLRAII 86
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFG-SKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2208669982  87 GGFRQQLEATEYTAGCPVApaalEGMNSPAALVAAGESFTSWEDTIAASLWQRGLSQDRSRGLATMAIASF 157
Cdd:COG1309    87 RAYLEFLAENPALARLLLA----EAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-57 1.21e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.25  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2208669982  11 LRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFPrGKPQLVEEA 57
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFG-SKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-57 4.01e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.46  E-value: 4.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2208669982   1 MSRST------AREDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFpRGKPQLVEEA 57
Cdd:PRK10668    1 MARKTkqqaqeTRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHF-KNKSDLFSEI 62
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-47 3.00e-05

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 42.58  E-value: 3.00e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2208669982   7 REDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFP 47
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFS 48
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
7-157 2.37e-12

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 61.84  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2208669982   7 REDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFPrGKPQLVEEATRTAGALMGSMISRGLASDGPAATLRAII 86
Cdd:COG1309     8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFG-SKEELLLAVLERLLEELLAALEEALAAEDPRERLRALL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2208669982  87 GGFRQQLEATEYTAGCPVApaalEGMNSPAALVAAGESFTSWEDTIAASLWQRGLSQDRSRGLATMAIASF 157
Cdd:COG1309    87 RAYLEFLAENPALARLLLA----EAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-57 1.21e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 46.25  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2208669982  11 LRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFPrGKPQLVEEA 57
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFG-SKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 1-57 4.01e-07

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 48.46  E-value: 4.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2208669982   1 MSRST------AREDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFpRGKPQLVEEA 57
Cdd:PRK10668    1 MARKTkqqaqeTRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHF-KNKSDLFSEI 62
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-56 9.23e-06

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 44.34  E-value: 9.23e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2208669982   1 MSRST------AREDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFpRGKPQLVEE 56
Cdd:PRK09975    1 MAKKTkaealkTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHF-ENKTQLFNE 61
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-47 3.00e-05

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 42.58  E-value: 3.00e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2208669982   7 REDMLRSAALLFRERGVEATSLADVIEHAGAPRGSIYHHFP 47
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFS 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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