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Conserved domains on  [gi|2209804167|ref|WP_241761918|]
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MULTISPECIES: universal stress protein [Weissella]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
8-145 1.33e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 86.51  E-value: 1.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAmsKEKTHAAYADVERALARYKEIAEEAGVkDV 87
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGP--EELEEELREEAEEALEEAAERLEEAGV-EV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  88 QMILAEGEPGPVIVkNIIPQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIV 145
Cdd:COG0589    79 ETVVREGDPAEAIL-EAAEELDADLIVMGSRgrSGLRRL-LLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
8-145 1.33e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 86.51  E-value: 1.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAmsKEKTHAAYADVERALARYKEIAEEAGVkDV 87
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGP--EELEEELREEAEEALEEAAERLEEAGV-EV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  88 QMILAEGEPGPVIVkNIIPQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIV 145
Cdd:COG0589    79 ETVVREGDPAEAIL-EAAEELDADLIVMGSRgrSGLRRL-LLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 10-145 2.67e-20

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.47  E-value: 2.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  10 HVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAMSKEKTHAAYADVERALARYKEIAEEAGVKdVQM 89
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGVE-VET 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2209804167  90 ILAEGEPGPVIVKNIIpQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIV 145
Cdd:cd00293    80 IVVEGDPAEAILEEAK-ELGADLIVMGSRgrSGLKRL-LLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 11-146 6.24e-19

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.06  E-value: 6.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  11 VLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFE-RDDMSVFDAMSKEKTHAAYADVERALARYKEIAEEAGVKDVQM 89
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDpPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2209804167  90 ILAEGEPGPVIVKnIIPQYDVDFVIIGSH--SNIGRAPyFGSQSSYVANNAPISVMIVR 146
Cdd:pfam00582  81 VVVVGDPAEEILE-VAEEEDADLIVMGSRgrSGLSRLL-LGSVAEYVLRHAPCPVLVVR 137
PRK15118 PRK15118
universal stress protein UspA;
8-120 1.51e-04

universal stress protein UspA;


Pssm-ID: 185073  Cd Length: 144  Bit Score: 39.48  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSI--VSVFERD------DMSVFDAMSK--EKTHAAyadveralarYKE 77
Cdd:PRK15118    3 YKHILIAVDLSPESKVLVEKAVSMARPYNAKVSLihVDVNYSDlytgliDVNLGDMQKRisEETHHA----------LTE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2209804167  78 IAEEAGVKDVQMILAEGEPGPVIVkNIIPQYDVDFVIIGSHSN 120
Cdd:PRK15118   73 LSTNAGYPITETLSGSGDLGQVLV-DAIKKYDMDLVVCGHHQD 114
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
8-145 1.33e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 86.51  E-value: 1.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAmsKEKTHAAYADVERALARYKEIAEEAGVkDV 87
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGP--EELEEELREEAEEALEEAAERLEEAGV-EV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  88 QMILAEGEPGPVIVkNIIPQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIV 145
Cdd:COG0589    79 ETVVREGDPAEAIL-EAAEELDADLIVMGSRgrSGLRRL-LLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 10-145 2.67e-20

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 80.47  E-value: 2.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  10 HVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAMSKEKTHAAYADVERALARYKEIAEEAGVKdVQM 89
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGVE-VET 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2209804167  90 ILAEGEPGPVIVKNIIpQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIV 145
Cdd:cd00293    80 IVVEGDPAEAILEEAK-ELGADLIVMGSRgrSGLKRL-LLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 11-146 6.24e-19

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.06  E-value: 6.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167  11 VLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFE-RDDMSVFDAMSKEKTHAAYADVERALARYKEIAEEAGVKDVQM 89
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDpPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2209804167  90 ILAEGEPGPVIVKnIIPQYDVDFVIIGSH--SNIGRAPyFGSQSSYVANNAPISVMIVR 146
Cdd:pfam00582  81 VVVVGDPAEEILE-VAEEEDADLIVMGSRgrSGLSRLL-LGSVAEYVLRHAPCPVLVVR 137
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 9-146 3.90e-18

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 75.35  E-value: 3.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   9 KHVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFERDDMSVFDAMS-----KEKTHAAYADVERALARYKEIAEEAG 83
Cdd:cd23659     1 RKVLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIEPPSLPAASLGSgseewEALEEEAREKAEKLLEKYEKKLKEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209804167  84 VKDVQMILAEGEPGPVIVKnIIPQYDVDFVIIGSH--SNIGRApYFGSQSSYVANNAPISVMIVR 146
Cdd:cd23659    81 GIKVKVEVVAGDPGEVICK-AAEELKADLIVMGSRglGALKRT-LLGSVSDYVVHHSPCPVLVVR 143
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 8-146 4.25e-07

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 46.15  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSIVSVFErdDMSVFDAMSKEKTHAAYADVERALAR--YKEIAEEAGVK 85
Cdd:cd23657     1 YKHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDE--DISEYYTGLIDVDIAALQDLESTMLEeaLKNLSELAGYP 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2209804167  86 DVQMILAEGEPGPVIVKnIIPQYDVDFVIIGSHSNIGRApYFGSQSSYVANNAPISVMIVR 146
Cdd:cd23657    79 VDHTFIGYGDLKEEILE-VAKKHNVDLIVCGHHGDFGLS-LLGSSARAVLNSAPCDVLIVP 137
PRK15118 PRK15118
universal stress protein UspA;
8-120 1.51e-04

universal stress protein UspA;


Pssm-ID: 185073  Cd Length: 144  Bit Score: 39.48  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2209804167   8 FKHVLVAVNDSKLGQMALVNAIHQALEDEAKLSI--VSVFERD------DMSVFDAMSK--EKTHAAyadveralarYKE 77
Cdd:PRK15118    3 YKHILIAVDLSPESKVLVEKAVSMARPYNAKVSLihVDVNYSDlytgliDVNLGDMQKRisEETHHA----------LTE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2209804167  78 IAEEAGVKDVQMILAEGEPGPVIVkNIIPQYDVDFVIIGSHSN 120
Cdd:PRK15118   73 LSTNAGYPITETLSGSGDLGQVLV-DAIKKYDMDLVVCGHHQD 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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