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Conserved domains on  [gi|2210533336|ref|WP_241966761|]
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PadR family transcriptional regulator [Haloplanus aerogenes]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 11447737)

PadR family transcriptional regulator similar to the phenolic acid decarboxylation repressor, which is a transcription factor that represses genes associated with the phenolic acid stress response in gram-positive bacteria

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10679470|10908318|10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
11-77 2.86e-09

DNA-binding transcriptional regulator, PadR family [Transcription];


:

Pssm-ID: 441301  Cd Length: 102  Bit Score: 48.78  E-value: 2.86e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2210533336  11 ILEALDEEQAHGYLLAERL--------DLSHGYIYTHLKELRQEGMIEVVDESEG----KKIYGLTENGEYLLKALIDR 77
Cdd:COG1695    14 ILALLAEGPMYGYEIIKELeersggfwKVSEGTLYPALKRLEKEGLVESEWEESEggprRKYYRLTEAGREELAEWLEE 92
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
11-77 2.86e-09

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 48.78  E-value: 2.86e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2210533336  11 ILEALDEEQAHGYLLAERL--------DLSHGYIYTHLKELRQEGMIEVVDESEG----KKIYGLTENGEYLLKALIDR 77
Cdd:COG1695    14 ILALLAEGPMYGYEIIKELeersggfwKVSEGTLYPALKRLEKEGLVESEWEESEggprRKYYRLTEAGREELAEWLEE 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 6-70 5.62e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.98  E-value: 5.62e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVVDESEgKKIYGLTENGEYL 70
Cdd:cd00090    7 PTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR-RVYYSLTDAERLL 70
PRK05638 PRK05638
threonine synthase; Validated
 7-74 2.62e-06

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 42.88  E-value: 2.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2210533336   7 TKVRILEALDEEQAHGYLLAERLDLSHGY--IYTHLKELRQEGMIEVVdESEGKKIY-GLTENGEYLLKAL 74
Cdd:PRK05638  372 TKLEILKILSEREMYGYEIWKALGKPLKYqaVYQHIKELEELGLIEEA-YRKGRRVYyKLTEKGRRLLENL 441
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 11-72 2.80e-04

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 35.30  E-value: 2.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2210533336 11 ILEALDEEQAHGYLLAERL--------DLSHGYIYTHLKELRQEGMIE--VVDESEGK--KIYGLTENGEYLLK 72
Cdd:pfam03551  1 VLAVLGEQPRYGYEIIKELeelsggfwRPSEGTLYPILKRLEKEGLVEseWVDSGGGPprKYYRLTDAGRRELA 74
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-61 9.81e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 9.81e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMieVVDESEGKKIY 61
Cdd:NF033788  11 PTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGL--VTSRREGRWVY 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
10-61 2.26e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 2.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2210533336  10 RILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVvdESEGKKIY 61
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVES--RREGKRVY 50
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
11-77 2.86e-09

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 48.78  E-value: 2.86e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2210533336  11 ILEALDEEQAHGYLLAERL--------DLSHGYIYTHLKELRQEGMIEVVDESEG----KKIYGLTENGEYLLKALIDR 77
Cdd:COG1695    14 ILALLAEGPMYGYEIIKELeersggfwKVSEGTLYPALKRLEKEGLVESEWEESEggprRKYYRLTEAGREELAEWLEE 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 6-70 5.62e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.98  E-value: 5.62e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVVDESEgKKIYGLTENGEYL 70
Cdd:cd00090    7 PTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR-RVYYSLTDAERLL 70
PRK05638 PRK05638
threonine synthase; Validated
 7-74 2.62e-06

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 42.88  E-value: 2.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2210533336   7 TKVRILEALDEEQAHGYLLAERLDLSHGY--IYTHLKELRQEGMIEVVdESEGKKIY-GLTENGEYLLKAL 74
Cdd:PRK05638  372 TKLEILKILSEREMYGYEIWKALGKPLKYqaVYQHIKELEELGLIEEA-YRKGRRVYyKLTEKGRRLLENL 441
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-68 6.05e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.75  E-value: 6.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2210533336   6 ETKVRILEALdeeQAHGYL----LAERLDLSHGYIYTHLKELRQEGMIEVVDESEG----KKIYGLTENGE 68
Cdd:COG2345    13 PTRRRILELL---KRAGPVtaaeLAEALGLTPNAVRRHLDALEEEGLVERETERRGrgrpAKLYRLTEAGR 80
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-61 1.71e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.41  E-value: 1.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVvdESEGKKIY 61
Cdd:COG0640   20 PTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTS--RREGRWVY 73
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-60 1.73e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.48  E-value: 1.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVVDESEGKKI 60
Cdd:COG4189   19 ETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGR 73
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 11-72 2.80e-04

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 35.30  E-value: 2.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2210533336 11 ILEALDEEQAHGYLLAERL--------DLSHGYIYTHLKELRQEGMIE--VVDESEGK--KIYGLTENGEYLLK 72
Cdd:pfam03551  1 VLAVLGEQPRYGYEIIKELeelsggfwRPSEGTLYPILKRLEKEGLVEseWVDSGGGPprKYYRLTDAGRRELA 74
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-54 4.65e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.44  E-value: 4.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 2210533336  6 ETKVRILEALDEEQAHGYL-LAERLDLSHGYIYTHLKELRQEGMIEVVDE 54
Cdd:pfam12840 10 PTRLRILRALVGDEPLTASeLARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-49 6.37e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.95  E-value: 6.37e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 2210533336  6 ETKVRILEALdeeQAHGYL----LAERLDLSHGYIYTHLKELRQEGMI 49
Cdd:pfam13412  1 ETDRKILNLL---QENPRIsqreLAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-61 9.81e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.97  E-value: 9.81e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 2210533336  6 ETKVRILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMieVVDESEGKKIY 61
Cdd:NF033788  11 PTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGL--VTSRREGRWVY 64
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
10-74 1.02e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 34.07  E-value: 1.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2210533336 10 RILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVVDEsEGKKIYGLTENGEYLLKAL 74
Cdd:COG3432   12 DILEALKNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDD-GGRRIYRITEKGREFLEKY 75
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
6-66 1.58e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 34.85  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2210533336   6 ETKVRILEAL-DEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVVDEsEGKKIYGLTEN 66
Cdd:COG3398    97 ETPRRILLYLlENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERD-GRNVRYYLNPP 157
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
10-61 2.26e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 32.95  E-value: 2.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2210533336  10 RILEALDEEQAHGYLLAERLDLSHGYIYTHLKELRQEGMIEVvdESEGKKIY 61
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVES--RREGKRVY 50
lstR PRK09416
PadR family transcriptional regulator;
5-77 7.78e-03

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 32.84  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2210533336   5 PETKVRILEALDEEQaHGYLLAERLDL--------SHGYIYTHLKELRQEGMIEVVDESEGKKIYGLTENGEYLLKALID 76
Cdd:PRK09416   42 EDILLAILQLLMNEK-TGYELLQLLRQrgiltfegNEGSLYTLLHRLEQNRFIQSSWDHEGAKYYQLTDKGNKMLRKAEK 120


                  .
gi 2210533336  77 R 77
Cdd:PRK09416  121 N 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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