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Conserved domains on  [gi|2218608637|ref|WP_243676005|]
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2Fe-2S iron-sulfur cluster-binding protein [Vulcanisaeta distributa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07569 super family cl32227
bidirectional hydrogenase complex protein HoxU; Validated
 1-203 2.14e-42

bidirectional hydrogenase complex protein HoxU; Validated


The actual alignment was detected with superfamily member PRK07569:

Pssm-ID: 181037 [Multi-domain]  Cd Length: 234  Bit Score: 142.48  E-value: 2.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGMVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNG--RLIPSCITKVSEGMKIETESTR 77
Cdd:PRK07569    1 MSVKTLTIDDQLVSAREGETLLEAAREAGIPIPTLCHLDGLSDvGACRLCLVEIEGsnKLLPACVTPVAEGMVVQTNTPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  78 VTEARKTLLKL--LLKNHTHRSKEEQMRCRICEYAVKYGLEPAPI---IPSVKVDDTHPAILFNPSACVMCRKCVIACGI 152
Cdd:PRK07569   81 LQEYRRMIVELlfAEGNHVCAVCVANGNCELQDLAIEVGMDHVRFpylFPRRPVDISHPRFGIDHNRCVLCTRCVRVCDE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 153 DQNNDVIAVIGRGSGTRVGFDLDTPPMGMSSCVSCGACVDACPTGGVNGKG 203
Cdd:PRK07569  161 IEGAHTWDVAGRGAKSRVITDLNQPWGTSETCTSCGKCVQACPTGAIFRKG 211
 
Name Accession Description Interval E-value
PRK07569 PRK07569
bidirectional hydrogenase complex protein HoxU; Validated
 1-203 2.14e-42

bidirectional hydrogenase complex protein HoxU; Validated


Pssm-ID: 181037 [Multi-domain]  Cd Length: 234  Bit Score: 142.48  E-value: 2.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGMVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNG--RLIPSCITKVSEGMKIETESTR 77
Cdd:PRK07569    1 MSVKTLTIDDQLVSAREGETLLEAAREAGIPIPTLCHLDGLSDvGACRLCLVEIEGsnKLLPACVTPVAEGMVVQTNTPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  78 VTEARKTLLKL--LLKNHTHRSKEEQMRCRICEYAVKYGLEPAPI---IPSVKVDDTHPAILFNPSACVMCRKCVIACGI 152
Cdd:PRK07569   81 LQEYRRMIVELlfAEGNHVCAVCVANGNCELQDLAIEVGMDHVRFpylFPRRPVDISHPRFGIDHNRCVLCTRCVRVCDE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 153 DQNNDVIAVIGRGSGTRVGFDLDTPPMGMSSCVSCGACVDACPTGGVNGKG 203
Cdd:PRK07569  161 IEGAHTWDVAGRGAKSRVITDLNQPWGTSETCTSCGKCVQACPTGAIFRKG 211
NuoG COG1034
NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production ...
 3-197 5.36e-42

NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440657 [Multi-domain]  Cd Length: 453  Bit Score: 146.91  E-value: 5.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   3 MVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNG--RLIPSCITKVSEGMKIETESTRVT 79
Cdd:COG1034     1 MVTITIDGKEVEVPKGTTVLQAAEKAGIEIPRFCYHPKLSIaGACRMCLVEVEGapKPVASCATPVTDGMVVKTDSPKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  80 EARKTLLKLLLKNHTHrskeeqmRCRICE---------YAVKYGLEPAPII---PSVKVDDTHPAILFNPSACVMCRKCV 147
Cdd:COG1034    81 KARKGVMEFLLINHPL-------DCPICDqggecdlqdQAMEYGVDESRYEeekRTVPKKDLGPLILLDMNRCILCTRCV 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2218608637 148 -----IAcgidqNNDVIAVIGRGSGTRVGFDLDTPpmgmSSCVSCGACVDACPTG 197
Cdd:COG1034   154 rfcdeIA-----GDPELGVIGRGEHSEIGTYLGKP----LDSEFSGNCIDVCPVG 199
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 3-75 3.42e-17

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 72.96  E-value: 3.42e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2218608637   3 MVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGF-----ANGSCRICIVEVNGR-LIPSCITKVSEGMKIETES 75
Cdd:pfam13510   3 PVTFTFDGRPVTAPEGDTIAAALLANGVRVPRSCKYGRPrgifcAMGECRNCLVEVDGVpNVRACTTPVREGMVVRTQN 81
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 4-72 1.85e-08

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 49.70  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   4 VKVLLNGKEVEALEGETILNLARRYGIEIPTLCYyegfaNGSCRICIVEVN------------------GRLIPSCITKV 65
Cdd:cd00207     3 INVPGSGVEVEVPEGETLLDAAREAGIDIPYSCR-----AGACGTCKVEVVegevdqsdpslldeeeaeGGYVLACQTRV 77


                  ....*..
gi 2218608637  66 SEGMKIE 72
Cdd:cd00207    78 TDGLVIE 84
 
Name Accession Description Interval E-value
PRK07569 PRK07569
bidirectional hydrogenase complex protein HoxU; Validated
 1-203 2.14e-42

bidirectional hydrogenase complex protein HoxU; Validated


Pssm-ID: 181037 [Multi-domain]  Cd Length: 234  Bit Score: 142.48  E-value: 2.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGMVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNG--RLIPSCITKVSEGMKIETESTR 77
Cdd:PRK07569    1 MSVKTLTIDDQLVSAREGETLLEAAREAGIPIPTLCHLDGLSDvGACRLCLVEIEGsnKLLPACVTPVAEGMVVQTNTPR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  78 VTEARKTLLKL--LLKNHTHRSKEEQMRCRICEYAVKYGLEPAPI---IPSVKVDDTHPAILFNPSACVMCRKCVIACGI 152
Cdd:PRK07569   81 LQEYRRMIVELlfAEGNHVCAVCVANGNCELQDLAIEVGMDHVRFpylFPRRPVDISHPRFGIDHNRCVLCTRCVRVCDE 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 153 DQNNDVIAVIGRGSGTRVGFDLDTPPMGMSSCVSCGACVDACPTGGVNGKG 203
Cdd:PRK07569  161 IEGAHTWDVAGRGAKSRVITDLNQPWGTSETCTSCGKCVQACPTGAIFRKG 211
NuoG COG1034
NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production ...
 3-197 5.36e-42

NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440657 [Multi-domain]  Cd Length: 453  Bit Score: 146.91  E-value: 5.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   3 MVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNG--RLIPSCITKVSEGMKIETESTRVT 79
Cdd:COG1034     1 MVTITIDGKEVEVPKGTTVLQAAEKAGIEIPRFCYHPKLSIaGACRMCLVEVEGapKPVASCATPVTDGMVVKTDSPKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  80 EARKTLLKLLLKNHTHrskeeqmRCRICE---------YAVKYGLEPAPII---PSVKVDDTHPAILFNPSACVMCRKCV 147
Cdd:COG1034    81 KARKGVMEFLLINHPL-------DCPICDqggecdlqdQAMEYGVDESRYEeekRTVPKKDLGPLILLDMNRCILCTRCV 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2218608637 148 -----IAcgidqNNDVIAVIGRGSGTRVGFDLDTPpmgmSSCVSCGACVDACPTG 197
Cdd:COG1034   154 rfcdeIA-----GDPELGVIGRGEHSEIGTYLGKP----LDSEFSGNCIDVCPVG 199
PRK08493 PRK08493
NADH-quinone oxidoreductase subunit G;
3-197 8.85e-33

NADH-quinone oxidoreductase subunit G;


Pssm-ID: 236277 [Multi-domain]  Cd Length: 819  Bit Score: 124.05  E-value: 8.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   3 MVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFA-NGSCRICIVEVNGRLIPSCITKVSEGMKIETESTRVTEA 81
Cdd:PRK08493    1 MITITINGKECEAQEGEYILNVARRNGIFIPAICYLSGCSpTLACRLCMVEADGKRVYSCNTKAKEGMNILTNTPNLMDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  82 RKTLLKLLLKNHThrskeeqMRCRICE---------YAVKYGLEPAPIipSVKvdDTHPA------ILFNPSACVMCRKC 146
Cdd:PRK08493   81 RNAIMQTYDVNHP-------LECGVCDksgecelqnFTHEMGVNHQPY--AIK--DTHKPhkhwgkINYDPSLCIVCERC 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2218608637 147 VIACgidqnNDVI------AVIGRGSGTRVGFDLDTP----------------PMG--MSSCVSCGACVDACPTG 197
Cdd:PRK08493  150 VTVC-----KDKIgesalkTVPRGLDAPDKSFKESMPkdayavwskkqksligPVGgeTLDCSFCGECIAVCPVG 219
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 1-83 1.61e-20

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 88.63  E-value: 1.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGMVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGF-ANGSCRICIVEVNG--RLIPSCITKVSEGMKIETESTR 77
Cdd:PRK12814    1 MNTISLTINGRSVTAAPGTSILEAAASAGITIPTLCFHQELeATGSCWMCIVEIKGknRFVPACSTAVSEGMVIETENAE 80


                  ....*.
gi 2218608637  78 VTEARK 83
Cdd:PRK12814   81 LHAMRR 86
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 3-75 3.42e-17

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 72.96  E-value: 3.42e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2218608637   3 MVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGF-----ANGSCRICIVEVNGR-LIPSCITKVSEGMKIETES 75
Cdd:pfam13510   3 PVTFTFDGRPVTAPEGDTIAAALLANGVRVPRSCKYGRPrgifcAMGECRNCLVEVDGVpNVRACTTPVREGMVVRTQN 81
PTZ00305 PTZ00305
NADH:ubiquinone oxidoreductase; Provisional
 6-175 3.53e-14

NADH:ubiquinone oxidoreductase; Provisional


Pssm-ID: 140326 [Multi-domain]  Cd Length: 297  Bit Score: 69.30  E-value: 3.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   6 VLLNGKEVEAL-EGETILNLARRYGIEIPTLCYYEGFA-NGSCRICIVEVNG--RLIPSCITKVSEGMKIETESTRVTEA 81
Cdd:PTZ00305   71 MFVNKRPVEIIpQEENLLEVLEREGIRVPKFCYHPILSvAGNCRMCLVQVDGtqNLVVSCATVALPGMSIITDSRLVRDA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  82 RKTLLKLLLKNHTHrskeeqmRCRICEYAVKYGLEPAPI-----IPSVKVD---------DTHPAILFNpsACVMCRKCV 147
Cdd:PTZ00305  151 REGNVELILINHPN-------DCPICEQATNCDLQNVSMnygtdIPRYKEDkravqdfyfDPQTRVVLN--RCIHCTRCV 221

                         170       180
                  ....*....|....*....|....*...
gi 2218608637 148 IACGIDQNNDVIAVIGRGSGTRVGFDLD 175
Cdd:PTZ00305  222 RFLNEHAQDFNLGMIGRGGLSEISTFLD 249
PRK07860 PRK07860
NADH dehydrogenase subunit G; Validated
 2-76 2.53e-10

NADH dehydrogenase subunit G; Validated


Pssm-ID: 236118 [Multi-domain]  Cd Length: 797  Bit Score: 59.19  E-value: 2.53e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2218608637   2 GMVKVLLNGKEVEALEGETILNLARRYGIEIPTLCYYEGFAN-GSCRICIVEVNGRLIP--SCITKVSEGMKIETEST 76
Cdd:PRK07860    3 DLVTLTIDGVEVSVPKGTLVIRAAELLGIQIPRFCDHPLLDPvGACRQCLVEVEGQRKPqaSCTTTVTDGMVVKTQLT 80
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
56-197 2.31e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 56.19  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  56 RLIPSCITKVSEGMKIETESTRVTEARKTLLKLLLKNHTH---------RSKEEQMRCRICEYAVKYGLEPAPIIpsvkV 126
Cdd:COG4624     4 LLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDddsacsccpRCCLCCCCCCRCCVAISCIQVRGIII----I 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 127 DDTHPAILFNPSACVMCRKCVIACGIDQnndviavigrgsgtrVGFDLDTPPMGMSSCVSCGACVDACPTG 197
Cdd:COG4624    80 DKRGPSIIRDKEKCKNCYPCVRACPVKA---------------IKVDDGKAEIDEEKCISCGQCVAVCPFG 135
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 4-72 1.85e-08

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 49.70  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   4 VKVLLNGKEVEALEGETILNLARRYGIEIPTLCYyegfaNGSCRICIVEVN------------------GRLIPSCITKV 65
Cdd:cd00207     3 INVPGSGVEVEVPEGETLLDAAREAGIDIPYSCR-----AGACGTCKVEVVegevdqsdpslldeeeaeGGYVLACQTRV 77


                  ....*..
gi 2218608637  66 SEGMKIE 72
Cdd:cd00207    78 TDGLVIE 84
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
133-197 8.59e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 48.13  E-value: 8.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2218608637 133 ILFNPSACVMCRKCVIACgidqnndviavigrgsgtRVGFDLDTPPMGMSSCVSCGACVDACPTG 197
Cdd:COG0348   205 VRYDRGDCIDCGLCVKVC------------------PMGIDIRKGEINQSECINCGRCIDACPKD 251
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 132-195 2.62e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 40.70  E-value: 2.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2218608637 132 AILFNPSACVMCRKCVIACGIDQNNDVIAVIGRGSGTRVGfdldtppmGMSSCVSCGACVDACP 195
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEAVRI--------GVWKCIGCGACVEACP 56
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 137-197 5.62e-05

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 39.73  E-value: 5.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 137 PSACVMCRKCVIACgidqNNDVIAVIGRGSGTRVGFDLDTppmgmssCVSCGACVDACPTG 197
Cdd:COG1143     1 EDKCIGCGLCVRVC----PVDAITIEDGEPGKVYVIDPDK-------CIGCGLCVEVCPTG 50
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 135-197 9.44e-05

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.65  E-value: 9.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2218608637 135 FNPSACVMCRKCVIACgidqnndVIAVIGRGSGTRVGFDLDtppmgmsSCVSCGACVDACPTG 197
Cdd:COG1144    27 VDEDKCIGCGLCWIVC-------PDGAIRVDDGKYYGIDYD-------YCKGCGICAEVCPVK 75
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 140-197 1.74e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 38.28  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2218608637 140 CVMCRKCVIACgidqNNDVIAVIGRGSGTRVgfdlDTPPMGMSSCVSCGACVDACPTG 197
Cdd:pfam12838   1 CIGCGACVAAC----PVGAITLDEVGEKKGT----KTVVIDPERCVGCGACVAVCPTG 50
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 138-199 2.02e-04

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 41.14  E-value: 2.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2218608637 138 SACVMCRKCVIACGIDqnndviAVIG--------RGSGTRVGF-DLDtppmgMSSCVSCGACVDACPTGGV 199
Cdd:PRK14028  247 SKCIMCRKCWLYCPDD------AIIEawreaegpRGRKFRMKMiDFD-----YQYCKGCGVCAEVCPTGAI 306
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
105-203 2.91e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 41.00  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637 105 RICEYAVKYGLEPAPIIPSVkvddthpailfNPSACVMCRKCVIAC---GIDQNNDVIAVIGRgsgtrvgfdldtppmgm 181
Cdd:COG1148   474 RAIQLLSKGELGVEPSVAEV-----------DPEKCTGCGRCVEVCpygAISIDEKGVAEVNP----------------- 525

                          90       100
                  ....*....|....*....|..
gi 2218608637 182 SSCVSCGACVDACPTGGVNGKG 203
Cdd:COG1148   526 ALCKGCGTCAAACPSGAISLKG 547
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 104-200 3.14e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 39.10  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637 104 CRICEYA---VKYGlEPAPIIPSVKVDDTHPAILFNPSACVMCRK--CVIAC-----GIDQNNDVIAVigrgsgtrvgfD 173
Cdd:cd10550    11 CRTCELAcslKHEG-VFNPSLSRIRVVRFEPEGLDVPVVCRQCEDapCVEACpvgaiSRDEETGAVVV-----------D 78

                          90       100
                  ....*....|....*....|....*..
gi 2218608637 174 LDTppmgmssCVSCGACVDACPTGGVN 200
Cdd:cd10550    79 EDK-------CIGCGMCVEACPFGAIR 98
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 1-49 6.41e-04

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 39.85  E-value: 6.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGM-VKVLLNGKEVEALEGETILNLARRYGIEIPTLCyyegfANGSCRIC 49
Cdd:PRK07609    1 MSFqVTLQPSGRQFTAEPDETILDAALRQGIHLPYGC-----KNGACGSC 45
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 135-197 1.37e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 36.24  E-value: 1.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2218608637 135 FNPSACVMCRKCVIACgidqNNDVIAVIGRGsgtrvgfdldTPPMGMSSCVSCGACVDACPTG 197
Cdd:COG1149     8 IDEEKCIGCGLCVEVC----PEGAIKLDDGG----------APVVDPDLCTGCGACVGVCPTG 56
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 132-197 1.82e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 37.62  E-value: 1.82e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2218608637 132 AILFNPSACVMCRKCVIAC----GIDQNNDVIAVIGRGSGTRVGFDLDTPPMgmsSCVSCG--ACVDACPTG 197
Cdd:COG0437     7 GMVIDLTKCIGCRACVVACkeenNLPVGVTWRRVRRYEEGEFPNVEWLFVPV---LCNHCDdpPCVKVCPTG 75
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 1-73 2.37e-03

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 36.99  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   1 MGMVKVLLNGK--EVEALEGETILNLAR--------RYGIEIptlcyyegfanGSCRICIVEVNGRLIPSCITKVS--EG 68
Cdd:COG2080     1 MMMITLTVNGKpvEVDVDPDTPLLDVLRddlgltgtKFGCGH-----------GQCGACTVLVDGKAVRSCLTLAVqaDG 69


                  ....*
gi 2218608637  69 MKIET 73
Cdd:COG2080    70 KEITT 74
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 132-198 2.65e-03

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 37.37  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637 132 AILFNPSACVMCRKCVIACgiDQNNDVIAVIGRGSGTrvgfdLDTPP------------------------MGMSSCVSC 187
Cdd:cd10558     1 AKLIDVSKCIGCKACQVAC--KEWNDLRAEVGHNVGT-----YQNPAdlspetwtlmkfrevedngklewlIRKDGCMHC 73

                          90
                  ....*....|...
gi 2218608637 188 G--ACVDACPTGG 198
Cdd:cd10558    74 AdpGCLKACPSPG 86
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
104-197 4.71e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 36.17  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637 104 CRICEYA---VKYGLEPAPIIPSVKVDDThpAILFNPSACVMC--RKCVIAC---GIDQNNDVIAVIGrgsgtrvgfdld 175
Cdd:COG1142    15 CRTCEAAcavAHEGEEGEPFLPRIRVVRK--AGVSAPVQCRHCedAPCAEVCpvgAITRDDGAVVVDE------------ 80

                          90       100
                  ....*....|....*....|..
gi 2218608637 176 tppmgmSSCVSCGACVDACPTG 197
Cdd:COG1142    81 ------EKCIGCGLCVLACPFG 96
Ubl_ThiS cd00565
ubiquitin-like (Ubl) domain found in sulfur carrier protein ThiS; ThiS, also termed Thiamine ...
 6-72 5.06e-03

ubiquitin-like (Ubl) domain found in sulfur carrier protein ThiS; ThiS, also termed Thiamine biosynthesis protein (ThiaminS), is a sulfur carrier protein involved in thiamin biosynthesis in prokaryotes. It has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin (Ub), and is activated in an ATP-dependent manner by sulfurtransferases, similar to the activation mechanism of Ub-activating enzyme E1. ThiS has common evolutionary origin with Ub-related protein modifiers in eukaryotes, a beta-grasp fold as Ub, and is closely related to proteins MoaD and Urm1.


Pssm-ID: 340451 [Multi-domain]  Cd Length: 64  Bit Score: 34.40  E-value: 5.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637   6 VLLNGKEVEALEGETILNLARRYGIEiptlcyYEGFAngscriciVEVNGRLIPS---CITKVSEGMKIE 72
Cdd:cd00565     1 ITVNGEPREVDEGLTLAELLEELGFT------PKGVA--------VELNGEIVPRsewAETILKDGDRIE 56
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 12-195 5.13e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 37.29  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  12 EVEALEGETILN----LARRYGieiPTLCYYEGFANGSCRICIVEVNGRLIPSCITKVSEGMKIETESTRVTE------A 81
Cdd:PRK06259   24 EVPVKEGMTVLDaleyINKTYD---ANIAFRSSCRAGQCGSCAVTINGEPVLACKTEVEDGMIIEPLDFPVIKdlivdrE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637  82 RKTLLKLLLKNHTHRSKEEQMRCRiceyavkyglepapiipsvKVDDTHPAilfnpSACVMCRKCVIACGIDQNNDV--- 158
Cdd:PRK06259  101 PYYKKLKSLRNYLQRKNEKITYPE-------------------DIEDIKKL-----RGCIECLSCVSTCPARKVSDYpgp 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2218608637 159 --------IAVIGRGSGTRVGFDLDTppmGMSSCVSCGACVDACP 195
Cdd:PRK06259  157 tfmrqlarFAFDPRDEGDREKEAFDE---GLYNCTTCGKCVEVCP 198
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 135-204 7.01e-03

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 35.49  E-value: 7.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2218608637 135 FNPSACVMCRKCVIACgidqnNDViAVIGRgSGTRVGFDldtppmgMSSCVSCGACVDACPTggvNGKGL 204
Cdd:PRK09625   56 HNNEICINCFNCWVYC-----PDA-AILSR-DKKLKGVD-------YSHCKGCGVCVEVCPT---NPKSL 108
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
10-72 7.57e-03

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 34.42  E-value: 7.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2218608637  10 GKEVEALEGETILNLA-RRYGIEIPTLCYyegfaNGSCRICIVEVNGRLIPSCITKVSEGMKIE 72
Cdd:pfam00111   7 GVTIEVPDGETTLLDAaEEAGIDIPYSCR-----GGGCGTCAVKVLEGEDQSDQSFLEDDELAA 65
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 172-197 8.38e-03

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 36.34  E-value: 8.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 2218608637 172 FDLDTPpmGMSSCVSCGACVDACPTG 197
Cdd:COG1600   176 LPPDEP--VEDHCGSCTRCLDACPTG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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