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Conserved domains on  [gi|2222341717|ref|WP_244529258|]
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tartrate dehydrogenase [Rhizobium sp. NFR03]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
7-359 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR02089:

Pssm-ID: 444908  Cd Length: 352  Bit Score: 598.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   7 RIHKIASIAGDGIGKEVVPEGLRVLEAASKKFG-FELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPD 85
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPW-SCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETV 165
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 166 MTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVV 245
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 246 ASNLFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVM 325
Cdd:TIGR02089 240 ASNLFGDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIM 319

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2222341717 326 AGIETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:TIGR02089 320 DAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
 
Name Accession Description Interval E-value
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 7-359 0e+00

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 598.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   7 RIHKIASIAGDGIGKEVVPEGLRVLEAASKKFG-FELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPD 85
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPW-SCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETV 165
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 166 MTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVV 245
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 246 ASNLFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVM 325
Cdd:TIGR02089 240 ASNLFGDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIM 319

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2222341717 326 AGIETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:TIGR02089 320 DAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 9-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 557.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   9 HKIASIAGDGIGKEVVPEGLRVLEAASKKFGFELRIDTFDfASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDVvP 88
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEAD-IGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 DHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETVMTR 168
Cdd:COG0473    80 DGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 169 IGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASN 248
Cdd:COG0473   160 KGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 249 LFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGI 328
Cdd:COG0473   239 LFGDILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2222341717 329 ETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:COG0473   317 EKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 10-360 0e+00

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 510.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFG-FELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDVVP 88
Cdd:PRK08194    5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGgLKFEFTEFPW-SCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKLVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 DHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGrgPGDIDFYVVRENTEGEYSSVGGRIFPGtERETVLQETVMTR 168
Cdd:PRK08194   84 DHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLAN--PKDFDLLVVRENSEGEYSEVGGRIHRG-EDEIAIQNAVFTR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 169 IGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASN 248
Cdd:PRK08194  161 KGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIVASN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 249 LFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGI 328
Cdd:PRK08194  240 LFGDILTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVI 319

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2222341717 329 ETVLADGrLRTRDLGGSADTVTCGKAVAETLR 360
Cdd:PRK08194  320 EDVTEDG-IKTPDIGGRATTDEVTDEIISRLK 350
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
10-355 7.44e-103

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 306.53  E-value: 7.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFElridtFDFASCD----YYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPD 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE-----FEFEERDvggaAIDETGEPLPDETLEACKKADAVLLGAVGGPK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMP--GVTSPLAgRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQE 163
Cdd:pfam00180  76 WDPAGVRPENGLLALRKELGLFANLRPAKVFPplGDASPLK-NEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 164 TVmTRIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMpYWDERVEEMAKA-YPDIAWDKYHIDILCAHFVLNPDRFD 242
Cdd:pfam00180 155 LY-SRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 243 VVVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDH-LGEHEAS 321
Cdd:pfam00180 233 VIVTPNLFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2222341717 322 AAVMAGIETVLADGrLRTRDLGGSADTVTC---GKAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESG-IRTGDLAGSATYVSTsefGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
10-360 6.28e-93

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 280.85  E-value: 6.28e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFelridTFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVgwpDVVPD 89
Cdd:NF040626    3 KITVIPGDGIGKEVMEAALYVLDALDLNFDF-----IEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---TSTPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  90 HISlwgSLIQFRREFDQYVSLRPVRLMPGVTSPLAgrgpgDIDFYVVRENTEGEYSsvgGRIFPGTErETVLQETVMTRI 169
Cdd:NF040626   75 QKS---PIITLRKELDLYANLRPIKSYEGINCLFK-----DLDFLIVRENTEGLYS---GLEEEYTE-EKAIAERVITRK 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 170 GVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASNL 249
Cdd:NF040626  143 ASERICKFAFEYAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNL 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 250 FGDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIE 329
Cdd:NF040626  223 FGDILSDEAAGLVGGLGLAPSANIGDKN---GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALE 299

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2222341717 330 TVLADGRLRTRDLGGSADTVTCGKAVAETLR 360
Cdd:NF040626  300 KVLREGKVVTPDLGGNAKTMEMANEIKKKIE 330
AksF_Meth NF040619
homoisocitrate dehydrogenase;
8-355 2.31e-79

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 246.21  E-value: 2.31e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   8 IHKIASIAGDGIGKEVVPEGLRVLeaasKKFG-FELridTFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDV 86
Cdd:NF040619    1 MPKICVIEGDGIGKEVIPETVRVL----KELGdFEF---IKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  87 VPDHISLWGS-LIQFRREFDQYVSLRPVRLMPgvtsplAGRGPGDIDFYVVRENTEGEYSsvgGRIFPGTERETVLQETV 165
Cdd:NF040619   74 TELKNKNYKSpILTLRKELDLYANVRPINNFG------DGQDVKNIDFVIIRENTEGLYV---GREYYDEENEIAIAERI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 166 MTRIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAY--PDIAWDKYHIDILCAHFVLNPDRFDV 243
Cdd:NF040619  145 ISKKGSERIIKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFDV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 244 VVASNLFGDILSDLGPACTGTIGIAPSGNINpERKfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAA 323
Cdd:NF040619  225 IVTTNLFGDILSDEASGLIGGLGLAPSANIG-DKK--GLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDL 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2222341717 324 VMAGIETVLADGRLrTRDLGGSADTVTCGKAV 355
Cdd:NF040619  302 IREAVKKCLENGKV-TPDLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 7-359 0e+00

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 598.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   7 RIHKIASIAGDGIGKEVVPEGLRVLEAASKKFG-FELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPD 85
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPW-SCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETV 165
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 166 MTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVV 245
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 246 ASNLFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVM 325
Cdd:TIGR02089 240 ASNLFGDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIM 319

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2222341717 326 AGIETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:TIGR02089 320 DAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 9-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 557.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   9 HKIASIAGDGIGKEVVPEGLRVLEAASKKFGFELRIDTFDfASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDVvP 88
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEAD-IGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 DHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETVMTR 168
Cdd:COG0473    80 DGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 169 IGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASN 248
Cdd:COG0473   160 KGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 249 LFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGI 328
Cdd:COG0473   239 LFGDILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2222341717 329 ETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:COG0473   317 EKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 10-360 0e+00

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 510.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFG-FELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDVVP 88
Cdd:PRK08194    5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGgLKFEFTEFPW-SCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKLVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 DHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGrgPGDIDFYVVRENTEGEYSSVGGRIFPGtERETVLQETVMTR 168
Cdd:PRK08194   84 DHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLAN--PKDFDLLVVRENSEGEYSEVGGRIHRG-EDEIAIQNAVFTR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 169 IGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASN 248
Cdd:PRK08194  161 KGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIVASN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 249 LFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGI 328
Cdd:PRK08194  240 LFGDILTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLLDVI 319

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2222341717 329 ETVLADGrLRTRDLGGSADTVTCGKAVAETLR 360
Cdd:PRK08194  320 EDVTEDG-IKTPDIGGRATTDEVTDEIISRLK 350
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 7-359 1.01e-137

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 395.45  E-value: 1.01e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   7 RIHKIASIAGDGIGKEVVPEGLRVLEAASKKfGFELRIDTFDFAScDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDV 86
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGA-RRYLRTGETLPDSVLAELRQHDAILLGAIGDPSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  87 vPDHISLWGSLIQFRREFDQYVSLRPVRLMPGVTSPLAGrgPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQETVM 166
Cdd:PRK03437   81 -PSGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSPLAG--PGDIDFVVVREGTEGPYTGNGGALRVGTPHEVATEVSVN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 167 TRIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVA 246
Cdd:PRK03437  158 TAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 247 SNLFGDILSDLGPACTGTIGIAPSGNINPERKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMA 326
Cdd:PRK03437  238 DNLFGDIITDLAAAVTGGIGLAASGNINPTGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEA 317

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2222341717 327 GIETVLADgrlrtrDLGGSADTVTCGKAVAETL 359
Cdd:PRK03437  318 AVEADLAE------RGKMGRSTAEVGDRIAARL 344
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 9-360 2.33e-127

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 369.43  E-value: 2.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   9 HKIASIAGDGIGKEVVPEGLRVLEAASKKFGFELRIDTFDFaSCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVG---WPD 85
Cdd:PRK00772    3 YKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALV-GGAAIDAHGVPLPEETLEACRAADAVLLGAVGgpkWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGsLIQFRREFDQYVSLRPVRLMPGVT--SPLAGRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQE 163
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLAdaSPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 164 TVMTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMpYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDV 243
Cdd:PRK00772  161 MVYTREEIERIARVAFELARKR-RKKVTSVDKANVLESSR-LWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 244 VVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDH-LGEHEASA 322
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESG--PGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEEAAD 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2222341717 323 AVMAGIETVLADGrLRTRDL---GGSADTVTCGKAVAETLR 360
Cdd:PRK00772  317 AIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAALA 356
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
10-355 7.44e-103

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 306.53  E-value: 7.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFElridtFDFASCD----YYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPD 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE-----FEFEERDvggaAIDETGEPLPDETLEACKKADAVLLGAVGGPK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMP--GVTSPLAgRGPGDIDFYVVRENTEGEYSSVGGRIFPGTERETVLQE 163
Cdd:pfam00180  76 WDPAGVRPENGLLALRKELGLFANLRPAKVFPplGDASPLK-NEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 164 TVmTRIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMpYWDERVEEMAKA-YPDIAWDKYHIDILCAHFVLNPDRFD 242
Cdd:pfam00180 155 LY-SRDEIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAeYPDVELEHQLVDNAAMQLVKNPSQFD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 243 VVVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDH-LGEHEAS 321
Cdd:pfam00180 233 VIVTPNLFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2222341717 322 AAVMAGIETVLADGrLRTRDLGGSADTVTC---GKAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESG-IRTGDLAGSATYVSTsefGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
10-360 6.28e-93

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 280.85  E-value: 6.28e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFelridTFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVgwpDVVPD 89
Cdd:NF040626    3 KITVIPGDGIGKEVMEAALYVLDALDLNFDF-----IEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---TSTPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  90 HISlwgSLIQFRREFDQYVSLRPVRLMPGVTSPLAgrgpgDIDFYVVRENTEGEYSsvgGRIFPGTErETVLQETVMTRI 169
Cdd:NF040626   75 QKS---PIITLRKELDLYANLRPIKSYEGINCLFK-----DLDFLIVRENTEGLYS---GLEEEYTE-EKAIAERVITRK 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 170 GVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASNL 249
Cdd:NF040626  143 ASERICKFAFEYAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNL 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 250 FGDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIE 329
Cdd:NF040626  223 FGDILSDEAAGLVGGLGLAPSANIGDKN---GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALE 299

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2222341717 330 TVLADGRLRTRDLGGSADTVTCGKAVAETLR 360
Cdd:NF040626  300 KVLREGKVVTPDLGGNAKTMEMANEIKKKIE 330
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 10-359 3.10e-89

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 271.97  E-value: 3.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFELRIDTFDF--ASCDyyvKHGQMMPDDWKAQIGSHDAIFFGAVGWP--D 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIggAAID---ATGQPLPEETLKGCKEADAVLLGAVGGPkwD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 VVPDHISLWGSLIQFRREFDQYVSLRPVRLMPGVT--SPLAGRGPGDIDFYVVRENTEGEYssVGGRifPGTERETVLQE 163
Cdd:TIGR00169  78 NLPRDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEdlSPLKEEIAKGVDFVVVRELTGGIY--FGEP--KGREGEGEAWD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 164 T-VMTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMpYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFD 242
Cdd:TIGR00169 154 TeVYTVPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 243 VVVASNLFGDILSDLGPACTGTIGIAPSGNINpeRKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDH-LGEHEAS 321
Cdd:TIGR00169 232 VVVTSNLFGDILSDEASVITGSLGMLPSASLG--SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2222341717 322 AAVMAGIETVLADGRlRTRDLGGSADTVTCGKAVAETL 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGY-RTPDLGSSATTAVGTAEMGEEL 346
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 8-359 3.93e-88

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 268.54  E-value: 3.93e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   8 IHKIASIAGDGIGKEVVPEGLRVLEAASKKFGFelridTFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGwpDVV 87
Cdd:PRK14025    1 MHKICVIEGDGIGKEVVPAALHVLEATGLPFEF-----VYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG--ETA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  88 PDHIslwgslIQFRREFDQYVSLRPVRLMPGVTSPLAgrgpgDIDFYVVRENTEGEYSsvggrifpGTERETVLQETVMT 167
Cdd:PRK14025   74 ADVI------VKLRRILDTYANVRPVKSYKGVKCLYP-----DIDYVIVRENTEGLYK--------GIEAEIADGVTVAT 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 168 RI----GVDRILKFAFDLAQTRP----RKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPD 239
Cdd:PRK14025  135 RVitrkASERIFRFAFEMAKRRKkmgkEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQ 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 240 RFDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHE 319
Cdd:PRK14025  215 TFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKY---GLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENE 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2222341717 320 ASAAVMAGIETVLADGrLRTRDLGGSADTVTCGKAVAETL 359
Cdd:PRK14025  292 EADKVEKALEEVLALG-LTTPDLGGNLSTMEMAEEVAKRV 330
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 11-356 9.60e-87

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 264.70  E-value: 9.60e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  11 IASIAGDGIGKEVVPEGLRVLEaaskKFGFELRIDTFDfASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPdVVPDH 90
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILN----KLGLEIEFIEFE-AGDEALKKYGSALPEDTLEEIRKADAILFGAVTTP-ANPGY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  91 ISLwgsLIQFRREFDQYVSLRPVRLMPGVTsplaGRGPGDIDFYVVRENTEGEYSSVGgRIFPgterETVLQETVMTRIG 170
Cdd:TIGR02088  75 KSV---IVTLRKELDLYANVRPAKSLPGIP----DLYPNGKDIVIVRENTEGLYAGFE-FGFS----DRAIAIRVITREG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 171 VDRILKFAFDLAQTRPRKrLTSATKSNGISISMPYWDERVEEMAKAYpDIAWDKYHIDILCAHFVLNPDRFDVVVASNLF 250
Cdd:TIGR02088 143 SERIARFAFNLAKERNRK-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMF 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 251 GDILSDLGPACTGTIGIAPSGNINpERKfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIET 330
Cdd:TIGR02088 221 GDILSDLASALAGSLGLAPSANIG-DRK--ALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEY 297

                         330       340
                  ....*....|....*....|....*.
gi 2222341717 331 VLADGRLrTRDLGGSADTVTCGKAVA 356
Cdd:TIGR02088 298 YIIEGKK-TPDLGGTAKTKEVGDEIA 322
AksF_Meth NF040619
homoisocitrate dehydrogenase;
8-355 2.31e-79

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 246.21  E-value: 2.31e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   8 IHKIASIAGDGIGKEVVPEGLRVLeaasKKFG-FELridTFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDV 86
Cdd:NF040619    1 MPKICVIEGDGIGKEVIPETVRVL----KELGdFEF---IKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  87 VPDHISLWGS-LIQFRREFDQYVSLRPVRLMPgvtsplAGRGPGDIDFYVVRENTEGEYSsvgGRIFPGTERETVLQETV 165
Cdd:NF040619   74 TELKNKNYKSpILTLRKELDLYANVRPINNFG------DGQDVKNIDFVIIRENTEGLYV---GREYYDEENEIAIAERI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 166 MTRIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAY--PDIAWDKYHIDILCAHFVLNPDRFDV 243
Cdd:NF040619  145 ISKKGSERIIKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFDV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 244 VVASNLFGDILSDLGPACTGTIGIAPSGNINpERKfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAA 323
Cdd:NF040619  225 IVTTNLFGDILSDEASGLIGGLGLAPSANIG-DKK--GLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDL 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2222341717 324 VMAGIETVLADGRLrTRDLGGSADTVTCGKAV 355
Cdd:NF040619  302 IREAVKKCLENGKV-TPDLGGNLKTKEVTDKI 332
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 10-359 7.18e-77

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 240.01  E-value: 7.18e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAASKKFGFElridtFDFASCDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPdvVPD 89
Cdd:PRK08997    4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYE-----FADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTP--VGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  90 HISlwgSL-IQFRREFDQYVSLRPVRLMPGVTSPLAgrgpgDIDFYVVRENTEGEYSSVGGRIFPgtERETVLQETVMTR 168
Cdd:PRK08997   77 GFT---SInVTLRKKFDLYANVRPVLSFPGTKARYD-----NIDIITVRENTEGMYSGEGQTVSE--DGETAEATSIITR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 169 IGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASN 248
Cdd:PRK08997  147 KGAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 249 LFGDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGI 328
Cdd:PRK08997  227 LFGDILSDLCAGLVGGLGMAPGANIGRDA---AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAI 303

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2222341717 329 ETVLADGRLRTRDLGGSADTVTCGKAVAETL 359
Cdd:PRK08997  304 VAVIEAGDRTTRDLGGTHGTTDFTQAVIDRL 334
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 9-359 7.29e-70

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 221.87  E-value: 7.29e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   9 HKIASIAGDGIGKEVVPEGLRVLEAASKKFGFElRIDTfdfascDYYVKHGQMMPDDWKAQIGSHDAIFFGAVGWPDVVP 88
Cdd:TIGR00175   4 YTVTLIPGDGIGPEISGSVKKIFRAANVPIEFE-EIDV------SPQTDGKTEIPDEAVESIKRNKVALKGPLETPIGKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 DHISLwgsLIQFRREFDQYVSLRPVRLMPGVTSPLAgrgpgDIDFYVVRENTEGEYSSVGGRIFPGteretVLQE-TVMT 167
Cdd:TIGR00175  77 GHRSL---NVALRKELDLYANVVHCKSLPGFKTRHE-----DVDIVIIRENTEGEYSGLEHESVPG-----VVESlKVIT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 168 RIGVDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVAS 247
Cdd:TIGR00175 144 RDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMP 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 248 NLFGDILSDLGPACTGTIGIAPSGNINpeRKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAG 327
Cdd:TIGR00175 224 NLYGNILSNLGAGLVGGPGLVPGANIG--RDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKA 301

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2222341717 328 IETVLADGRLRTRDLGGSADTVTCGKAVAETL 359
Cdd:TIGR00175 302 VLSTIAEGKNRTKDLGGTATTSDFTEAVIKRL 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
10-342 4.90e-57

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 192.80  E-value: 4.90e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  10 KIASIAGDGIGKEVVPEGLRVLEAAskkfGFELRIDTfdfascdyyvkhgqmmpddwkAQIGshDAIFfgAVGWPDVVPD 89
Cdd:PRK09222    6 PITVAYGDGIGPEIMEAVLKILEAA----GAPLEIET---------------------IEIG--EKVY--KKGWTSGISP 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  90 hiSLWGSL-----------------------IQFRREFDQYVSLRPVR-LMPGVTSPLAGrgpgdIDFYVVRENTEGEYS 145
Cdd:PRK09222   57 --SAWESIrrtkvllkapittpqgggykslnVTLRKTLGLYANVRPCVsYHPFVETKHPN-----LDVVIIRENEEDLYA 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 146 svggrifpGTE-RET--VLQET-VMTRIGVDRILKFAFDLAQTRPRKRLTSATKSNgisIsMPYWD---ERV-EEMAKAY 217
Cdd:PRK09222  130 --------GIEhRQTpdVYQCLkLISRPGSEKIIRYAFEYARANGRKKVTCLTKDN---I-MKLTDglfHKVfDEIAKEY 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 218 PDIAWDKYHIDILCAHFVLNPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSAPDIAGQG 297
Cdd:PRK09222  198 PDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY---AMFEAVHGSAPDIAGKN 274

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2222341717 298 IANPIGQIWSAAMMLDHLGEHEASAAVM-AGIETvLADGrLRTRDL 342
Cdd:PRK09222  275 IANPSGLLNAAVMMLVHIGQFDIAELIEnAWLKT-LEDG-IHTADI 318
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 101-359 8.89e-54

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 181.23  E-value: 8.89e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 101 RREFDQYVSLRPVRLMPGVTSPLagrgpGDIDFYVVRENTEGEYSSVGGRIFPGTeretVLQETVMTRIGVDRILKFAFD 180
Cdd:PLN00118  125 RKELGLYANVRPCYSLPGYKTRY-----DDVDLVTIRENTEGEYSGLEHQVVRGV----VESLKIITRQASLRVAEYAFH 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 181 LAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASNLFGDILSDLGPA 260
Cdd:PLN00118  196 YAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAG 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 261 CTGTIGIAPSGNINpeRKFPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIETVLADGRLRTR 340
Cdd:PLN00118  276 LIGGLGLTPSCNIG--ENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTA 353

                         250
                  ....*....|....*....
gi 2222341717 341 DLGGSADTVTCGKAVAETL 359
Cdd:PLN00118  354 DLGGSSTTTDFTKAICDHL 372
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 9-357 1.18e-46

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 163.71  E-value: 1.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717   9 HKIASIAGDGIGKEVVPEGLRVLEAASKKFGFELRIDTFDF--ASCDYYvkhGQMMPDDWKAQIGSHDAIFFGAVG---W 83
Cdd:PLN02329   47 YNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVggAALDLV---GVPLPEETFTAAKQSDAILLGAIGgykW 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  84 pDVVPDHISLWGSLIQFRREFDQYVSLRPVRLMPGV--TSPLAGRGPGDIDFYVVRENTEGEY-SSVGGRIFPGTERETV 160
Cdd:PLN02329  124 -DKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEVAEGVDMMIVRELTGGIYfGEPRGITINENGEEVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 161 LQETVMTRIGVDRILKFAFDLAQTRpRKRLTSATKSNGISISMpYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDR 240
Cdd:PLN02329  203 VSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQ 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 241 FDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPERkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDH-LGEHE 319
Cdd:PLN02329  281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2222341717 320 ASAAVMAGIETVLADGrLRTRDLGGSADTVTCGKAVAE 357
Cdd:PLN02329  359 AAKRIEDAVVDALNKG-FRTGDIYSPGNKLVGCKEMGE 395
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 11-360 8.59e-46

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 161.05  E-value: 8.59e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  11 IASIAGDGIGKEVVPEGLRVLEAA-SKKFGFELRIDTFDF-ASCDYYVKHGQMMPDDwkaqigSHDAI-FFG-AV----- 81
Cdd:COG0538    21 IPFIEGDGIGPEITRAIWKVIDAAvEKAYGGKRDIEWKEVdAGEKARDETGDWLPDE------TAEAIkEYGvGIkgplt 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  82 -----GWPdvvpdhiSLWGSLiqfRREFDQYVSLRPVRLMPGVTSPLagRGPGDIDFYVVRENTEGEYS----SVGGrif 152
Cdd:COG0538    95 tpvggGWR-------SLNVTI---RQILDLYVCRRPVRYFKGVPSPV--KHPEKVDIVIFRENTEDIYAgiewKAGS--- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 153 PGTE--RETVLQET----------------VMTRIGVDRILKFAFDLAQTRPRKRLTSATKSNgisIsMPYWDERV---- 210
Cdd:COG0538   160 PEALklIFFLEDEMgvtvirfpedsgigikPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGN---I-MKFTEGAFkdwg 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 211 EEMAKA-YPD--IAWDKYH-----------------IDILCAHFVLNPDRFDVVVASNLFGDILSDLGPACTGTIGIAPS 270
Cdd:COG0538   236 YEVAEEeFGDkfITEGPWEkykgpkpagkivykdriADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 271 GNINPERKFpsLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIETVLADGRLrTRDLG---GSAD 347
Cdd:COG0538   316 ANIGDDGGA--EFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDLArlmEGAT 392

                         410
                  ....*....|....*.
gi 2222341717 348 TVTC---GKAVAETLR 360
Cdd:COG0538   393 ELSTsefGDAIIENLD 408
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 14-359 1.02e-42

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 151.94  E-value: 1.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  14 IAGDGIGKEVVPEGLRVLEAASKKFGFElridTFDFascdyyvkHGQMM--PDDWKAQIGSHDAIFFGAVGWPdvVPDHI 91
Cdd:PLN00123   36 IPGDGIGPLVTGAVEQVMEAMHAPVYFE----RYEV--------HGDMKkvPEEVLESIRRNKVCLKGGLATP--VGGGV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  92 SlwgSL-IQFRREFDQYVSLRPVRLMPGvtspLAGRGpGDIDFYVVRENTEGEYSSVGGRIFPGTeretVLQETVMTRIG 170
Cdd:PLN00123  102 S---SLnVQLRKELDLFASLVNCFNLPG----LPTRH-ENVDIVVIRENTEGEYSGLEHEVVPGV----VESLKVITKFC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 171 VDRILKFAFDLAQTRPRKRLTSATKSNGISISMPYWDERVEEMAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASNLF 250
Cdd:PLN00123  170 SERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLY 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 251 GDILSDLGPACTGTIGIAPSGNINPERkfpSLFEPVHGSA----PDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMA 326
Cdd:PLN00123  250 GNLVANTAAGIAGGTGVMPGGNVGADH---AVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLET 326

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2222341717 327 GIETVLADGRLRTRDLGGSADTVTCGKAVAETL 359
Cdd:PLN00123  327 AVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 11-333 1.29e-33

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 128.64  E-value: 1.29e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  11 IASIAGDGIGKEVVPEGLRVLEAASKK-FGFELRIDTFD-FASCDYYVKHGqmmPDDWKAQiGSHDAI--FFGAVGWPDV 86
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAAVEKaYKGERKISWMEiYAGEKATKVYG---EDVWLPE-ETLDLIreYRVAIKGPLT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  87 VPdhisLWG---SL-IQFRREFDQYVSLRPVRLMPGVTSPLagRGPGDIDFYVVRENTEGEYSsvgGRIFP-GT-ERETV 160
Cdd:PRK07006   98 TP----VGGgirSLnVALRQELDLYVCLRPVRYFKGVPSPV--KRPEDTDMVIFRENSEDIYA---GIEWKaGSaEAKKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 161 ---LQETV-----------------MTRIGVDRILKFAFDLAQTRPRKRLTSATKSN----------------------G 198
Cdd:PRK07006  169 ikfLQEEMgvkkirfpetsgigikpVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNimkftegafkdwgyqlaeeefgD 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 199 ISISMPYWDeRVEEmAKAYPDIAWDKYHIDILCAHFVLNPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPERk 278
Cdd:PRK07006  249 ELIDGGPWD-KIKN-PETGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGH- 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2222341717 279 fpSLFEPVHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIETVLA 333
Cdd:PRK07006  326 --AIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA 378
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
11-342 2.06e-28

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 114.16  E-value: 2.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  11 IASIAGDGIGKEVVPEGLRVLEAASKK-FGFELRIDTFDFASCDYYVK-HGQMMPDDWKAQIGSHDAIFFGAVGWPdvvp 88
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINKAVEKaYGSDREIKWVEVLAGDKAEKlTGNRFPKESEELIEKYRVLLKGPLETP---- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  89 dhISL-WGSL-IQFRREFDQYVSLRPVRLMPGVTSPLagRGPGDIDFYVVRENTEGEY--------SSVGGRI--FPGTE 156
Cdd:PRK06451  102 --IGKgWKSInVAIRLMLDLYANIRPVKYIPGIESPL--KNPEKIDLIIFRENTDDLYrgieypydSEEAKKIrdFLRKE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 157 RETVLQE------TVMTRIGVDRILKFAFDLAQTRPRKRLTSATKSNgisiSMPY-------WDERV------------E 211
Cdd:PRK06451  178 LGVEVEDdtgigiKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGN----VMKYtegafreWAYEValkefrdyvvteE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 212 EMAKAYPDIAWDKYHI------DILCAHFVLNPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPErkfPSLFEP 285
Cdd:PRK06451  254 EVTKNYNGVPPSGKVIindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDT---GGMFEA 330

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2222341717 286 VHGSAPDIAGQGIANPIGQIWSAAMMLDHLGEHEASAAVMAGIETVLADGRLrTRDL 342
Cdd:PRK06451  331 IHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDL 386
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
11-342 1.28e-14

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 74.75  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  11 IASIAGDGIGKEVVPEGLRVLEAASKK-FGFELRIDTFD-FA---SCDYYVKHgQMMPDDWKAQIGSHDAIFFGAVGWPd 85
Cdd:PRK07362   31 IPFIRGDGTGVDIWPATQKVLDAAVAKaYGGERKINWFKvYAgdeACDLYGTY-QYLPEDTLEAIREYGVAIKGPLTTP- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717  86 vVPDHISlwgSL-IQFRREFDQYVSLRPVRLMPGVTSPlaGRGPGDIDFYVVRENTEGEY-------------------- 144
Cdd:PRK07362  109 -IGGGIR---SLnVALRQIFDLYSCVRPCRYYAGTPSP--HKNPEKLDVIVYRENTEDIYmgieweagdeigdklikhln 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 145 -------SSVGGRIFP-------------GTER------ETVLQ----ETVMTRIGVDRILKF---AF-----DLAQTRP 186
Cdd:PRK07362  183 eevipasPELGKRQIPlgsgigikpvsktGSQRhirraiEHALRlpgdKRHVTLVHKGNIMKYtegAFrdwgyELATTEF 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 187 RKR---------LTSATKSNGISISM------PYWD-------ERVEEMAKAYPDIAW---------DKYHIDILCAHFV 235
Cdd:PRK07362  263 RDEcvtereswiLSNKEKNPNISIEDnarmiePGYDsltpekkAAICAEVKEVLDSIWsshgngkwkEKVLVDDRIADSI 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2222341717 236 LN-----PDRFDVVVASNLFGDILSDLGPACTGTIGIAPSGNINPErkfPSLFEPVHGSAPDIAGQGIANPIGQIWSAAM 310
Cdd:PRK07362  343 FQqiqtrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDN---AAIFEATHGTAPKHAGLDRINPGSVILSGVM 419

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2222341717 311 MLDHLGEHEASAAVMAGIETVLADGRLrTRDL 342
Cdd:PRK07362  420 MLEYLGWQEAADLITKGLSAAIANKQV-TYDL 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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