|
Name |
Accession |
Description |
Interval |
E-value |
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
14-438 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 829.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 14 TNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSL 93
Cdd:COG2873 3 EKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 94 AVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSL 173
Cdd:COG2873 83 ATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 174 SVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWN-SPKFPGFITP 252
Cdd:COG2873 163 DVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAaNGKFPELTEP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 253 DASYHDLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPE 332
Cdd:COG2873 243 DPSYHGLVYTEAFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 333 VPSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSED 412
Cdd:COG2873 323 LPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPD 402
|
410 420
....*....|....*....|....*.
gi 2225629504 413 LIRLSIGIEHIDDILNDLEQAIEVAT 438
Cdd:COG2873 403 LIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
18-435 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 687.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLD 177
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 178 IEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWNSPKFPGFITPDASYH 257
Cdd:TIGR01326 161 IEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGRFPLFTTPDPSYH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 258 DLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHP 337
Cdd:TIGR01326 241 GLVFTETLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 338 QVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLS 417
Cdd:TIGR01326 321 HHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLS 400
|
410
....*....|....*...
gi 2225629504 418 IGIEHIDDILNDLEQAIE 435
Cdd:TIGR01326 401 VGIENIDDIIADLEQALE 418
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
15-438 |
0e+00 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 665.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 15 NKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLA 94
Cdd:PRK08248 5 RTFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 95 VSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLS 174
Cdd:PRK08248 85 VSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 175 VLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDW-NSPKFPGFITPD 253
Cdd:PRK08248 165 VLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWkGSGKFPGLTEPD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 254 ASYHDLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEV 333
Cdd:PRK08248 245 PSYHGLVYTDAVGEAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 334 PSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDL 413
Cdd:PRK08248 325 PSHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGL 404
|
410 420
....*....|....*....|....*
gi 2225629504 414 IRLSIGIEHIDDILNDLEQAIEVAT 438
Cdd:PRK08248 405 VRLSVGTEAIDDILDDLRQAIRQSQ 429
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-437 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 633.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 14 TNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSL 93
Cdd:PRK07812 9 TANWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 94 AVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFV-DQSNPENFRQAITPHTKAIYAETIGNPS 172
Cdd:PRK07812 89 LLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 173 LSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWNSPKFPGFITP 252
Cdd:PRK07812 169 IDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQGRFPGFTTP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 253 DASYHDLVYAEaIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPE 332
Cdd:PRK07812 249 DPSYHGVVFAE-LGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 333 VPSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSED 412
Cdd:PRK07812 328 LPSSPWYERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPG 407
|
410 420
....*....|....*....|....*
gi 2225629504 413 LIRLSIGIEHIDDILNDLEQAIEVA 437
Cdd:PRK07812 408 LVRLAVGIEGIDDILADLEAGFAAA 432
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-444 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 595.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:PRK08134 8 GFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLD 177
Cdd:PRK08134 88 GQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 178 IEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWN-SPKFPGFITPDASY 256
Cdd:PRK08134 168 IPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDWEaSGKFPELTEPYAGF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 257 HDLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSH 336
Cdd:PRK08134 248 HGMVFAEESTVAAFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 337 PQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRL 416
Cdd:PRK08134 328 PDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRL 407
|
410 420
....*....|....*....|....*...
gi 2225629504 417 SIGIEHIDDILNDLEQAIEVAtgQKSAS 444
Cdd:PRK08134 408 SIGLEDADDLIDDLKRALKAA--EKAGA 433
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
19-437 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 548.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 19 LETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSG 98
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 99 MAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDI 178
Cdd:PRK05994 88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 179 EAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWN-SPKFPGFITPDASYH 257
Cdd:PRK05994 168 AAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSkSGKYPMLSEPRPEYH 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 258 DLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHP 337
Cdd:PRK05994 248 GLVLHETFGNFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDP 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 338 QVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLS 417
Cdd:PRK05994 328 YHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLS 407
|
410 420
....*....|....*....|
gi 2225629504 418 IGIEHIDDILNDLEQAIEVA 437
Cdd:PRK05994 408 IGIEDVDDIIADLEQALAKA 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
18-439 |
0e+00 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 514.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:PRK06084 2 KLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLD 177
Cdd:PRK06084 82 GMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 178 IEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDW--NSPKFPGFITPDAS 255
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWaeHKERFALLNTPDPS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 256 YHDLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPS 335
Cdd:PRK06084 242 YHGVTYTEAFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 336 HPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIR 415
Cdd:PRK06084 322 HPEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|....
gi 2225629504 416 LSIGIEHIDDILNDLEQAIEVATG 439
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDASKG 425
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
17-437 |
3.39e-176 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 498.03 E-value: 3.39e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 17 YRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVS 96
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 97 SGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVL 176
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 177 DIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasy 256
Cdd:COG0626 161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV---------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 257 hdlvyaeaiGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSH 336
Cdd:COG0626 219 ---------GRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSH 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 337 PQVKEASKYLpKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRL 416
Cdd:COG0626 290 PGHELAKRQM-SGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRL 368
|
410 420
....*....|....*....|.
gi 2225629504 417 SIGIEHIDDILNDLEQAIEVA 437
Cdd:COG0626 369 SVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
20-435 |
4.42e-175 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 494.83 E-value: 4.42e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 20 ETIGVHGGLQPDPLTGARALPIYMSNAYQFKdtdhaanlFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGM 99
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 100 AAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIE 179
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 180 AVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKfdwnspkfpgfitpdasyhdl 259
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGE--------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 260 vyaeaigtaaYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQV 339
Cdd:pfam01053 212 ----------ELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGH 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 340 KEASKYLpKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIG 419
Cdd:pfam01053 282 ELAKRQM-KGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVG 360
|
410
....*....|....*.
gi 2225629504 420 IEHIDDILNDLEQAIE 435
Cdd:pfam01053 361 IEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
35-435 |
7.32e-175 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 494.03 E-value: 7.32e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 35 GARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGD 114
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 115 EIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHEAGIPLII 194
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 195 DNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKfdwnspkfpgfitpdasyhdlvyaeaigtaAYIVKA 274
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGE------------------------------ALIQRL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 275 RVQLLRdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQVKEASKYLpKGAGAVV 354
Cdd:cd00614 211 RFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQM-SGYGGVF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 355 VFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIGIEHIDDILNDLEQAI 434
Cdd:cd00614 289 SFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQAL 368
|
.
gi 2225629504 435 E 435
Cdd:cd00614 369 K 369
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
15-435 |
2.80e-163 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 467.43 E-value: 2.80e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 15 NKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLA 94
Cdd:PRK05613 10 DQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 95 VSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFV-DQSNPENFRQAITPHTKAIYAETIGNPSL 173
Cdd:PRK05613 90 FASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 174 SVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWN-----SPKFPG 248
Cdd:PRK05613 170 DVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTverdgKPVFPY 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 249 FITPDASYHDLVYAEaIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWV 328
Cdd:PRK05613 250 FVTPDPAYHGLKYAD-LGAPAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 329 LYPEVPSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAG 408
Cdd:PRK05613 329 NFAGLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAG 408
|
410 420
....*....|....*....|....*..
gi 2225629504 409 VSEDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK05613 409 ITQATVRLSVGIEDIDDIIADLEGGFA 435
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
10-434 |
1.94e-142 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 414.07 E-value: 1.94e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 10 MGEGTNKyrlETIGVHGGLQPDPlTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGG 89
Cdd:PRK06702 1 MGESWGK---GTICVQGGYTPKN-GEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 90 VGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQS-NPENFRQAITPHTKAIYAETI 168
Cdd:PRK06702 77 VGAVATASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 169 GNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWNSPKFPG 248
Cdd:PRK06702 157 GNPAMNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNGKYPE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 249 FITPDASYHDLVYAEAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWV 328
Cdd:PRK06702 237 LVEPDPSYHGVSYVQNFGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 329 LYPEVPSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAG 408
Cdd:PRK06702 317 NYPGLDSNENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAG 396
|
410 420
....*....|....*....|....*.
gi 2225629504 409 VSEDLIRLSIGIEHIDDILNDLEQAI 434
Cdd:PRK06702 397 VTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
14-431 |
2.91e-135 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 394.37 E-value: 2.91e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 14 TNKYRLETIGVHGGLQPDPLtGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSL 93
Cdd:PRK08133 2 DDSLGFDTLAVRAGQLRSPF-GEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 94 AVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSL 173
Cdd:PRK08133 81 ATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 174 SVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFdwnspkfpgfitpd 253
Cdd:PRK08133 161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKEL-------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 254 asyhdlvyaeaigtaayiVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEV 333
Cdd:PRK08133 227 ------------------MEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 334 PSHPQVKEASKYlPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDL 413
Cdd:PRK08133 289 PSHPQHELAKRQ-QKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGL 367
|
410
....*....|....*...
gi 2225629504 414 IRLSIGIEHIDDILNDLE 431
Cdd:PRK08133 368 IRVAVGLEDVADIKADLA 385
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
21-435 |
1.97e-131 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 384.95 E-value: 1.97e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 21 TIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMA 100
Cdd:PRK06234 11 TKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEA 180
Cdd:PRK06234 91 AISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 181 VATIAHEA--GIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasyhd 258
Cdd:PRK06234 171 ISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV------------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 259 lvyaeaiGTAAYIVKARVQLLRDL-GVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHP 337
Cdd:PRK06234 227 -------GKEEFINQVKLFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 338 QVKEASKYLpKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLS 417
Cdd:PRK06234 300 YYELAKKQM-SLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLS 378
|
410
....*....|....*...
gi 2225629504 418 IGIEHIDDILNDLEQAIE 435
Cdd:PRK06234 379 VGLEDVDDIIADLKQALD 396
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
20-434 |
2.69e-119 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 353.38 E-value: 2.69e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 20 ETIGVHGGLQPDPLtGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGM 99
Cdd:TIGR01325 1 ATLAVRGGMLRSGF-EETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 100 AAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIE 179
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 180 AVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfitpdasyhdl 259
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAI-------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 260 vyaeaIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQV 339
Cdd:TIGR01325 214 -----LGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQH 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 340 KEASKYLpKGAGAVVVFGIaGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIG 419
Cdd:TIGR01325 289 ELAKRQM-SGGGTVVTFDL-DCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVG 366
|
410
....*....|....*
gi 2225629504 420 IEHIDDILNDLEQAI 434
Cdd:TIGR01325 367 LEDVDDLIADIDRAL 381
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
10-443 |
1.73e-115 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 344.48 E-value: 1.73e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 10 MGEGTNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGG 89
Cdd:PRK07503 1 MRDSHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 90 VGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIG 169
Cdd:PRK07503 81 EAAVALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 170 NPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGttlggvivdggkfdwnspkfpgf 249
Cdd:PRK07503 161 NPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHG----------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 250 itpdasyhDLVYAEAIGTAAYIVKARVQLLRDL-GVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWV 328
Cdd:PRK07503 218 --------DITAGLVVGGKALADRIRLEGLKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELV 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 329 LYPEVPSHPQVKEASKYLPKGaGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAG 408
Cdd:PRK07503 290 HYPGLPSFAQHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHG 368
|
410 420 430
....*....|....*....|....*....|....*
gi 2225629504 409 VSEDLIRLSIGIEHIDDILNDLEQAIEVATGQKSA 443
Cdd:PRK07503 369 ISEGLVRLSVGLEDVADILADLAQALDACAVAAAA 403
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
20-435 |
2.24e-115 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 343.79 E-value: 2.24e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 20 ETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGM 99
Cdd:TIGR01328 5 ATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 100 AAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIE 179
Cdd:TIGR01328 85 GAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDME 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 180 AVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfitpdasyhdl 259
Cdd:TIGR01328 165 RVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLI-------------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 260 vyaeaIGTAAYIVKARVQLLRDL-GVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQ 338
Cdd:TIGR01328 219 -----CGKAELLQQIRMVGIKDMtGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 339 VKEASKYLPKGaGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSI 418
Cdd:TIGR01328 294 HDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSV 372
|
410
....*....|....*..
gi 2225629504 419 GIEHIDDILNDLEQAIE 435
Cdd:TIGR01328 373 GLEDADDLIADLKQALD 389
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
9-435 |
4.48e-113 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 337.77 E-value: 4.48e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 9 MMGEGTNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQfkdTDHAANLfalqEPGYIYTRIHNPTVSVFEERVAQLEG 88
Cdd:PRK07811 3 DMSDHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFA---QDGVGGL----RGGYEYARTGNPTRTALEEQLAALEG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 89 GVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETI 168
Cdd:PRK07811 76 GAYGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 169 GNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpg 248
Cdd:PRK07811 156 TNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALV-------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 249 fiTPDASyhdlvYAEAIgtaAYIVKArvqllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWV 328
Cdd:PRK07811 222 --TNDEE-----LDEAF---AFLQNG-------AGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 329 LYPEVPSHPQVKEASKYLpKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKeag 408
Cdd:PRK07811 285 LYPGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLE--- 360
|
410 420
....*....|....*....|....*..
gi 2225629504 409 VSEDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK07811 361 VPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
9-439 |
3.43e-112 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 335.57 E-value: 3.43e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 9 MMGEGTNKYRLETIGVHGGLQPDPLtGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEG 88
Cdd:PRK07504 1 MTTEMARKWRPATRLVHSGTLRSQF-GETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 89 GVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETI 168
Cdd:PRK07504 80 AEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 169 GNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFdwnspkfpg 248
Cdd:PRK07504 160 TNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAW--------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 249 fitPDASYHDlvyaeaigtaayivkarvqLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWV 328
Cdd:PRK07504 231 ---IEEHLQD-------------------YFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 329 LYPEVPSHPQVKEASKYLpKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAG 408
Cdd:PRK07504 289 IYPGRADHPQADIIAKQM-TGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELG 367
|
410 420 430
....*....|....*....|....*....|.
gi 2225629504 409 VSEDLIRLSIGIEHIDDILNDLEQAIEVATG 439
Cdd:PRK07504 368 ISEGFLRLSAGLEDTDDLIEDLAAALKKVRA 398
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
16-435 |
6.09e-112 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 334.50 E-value: 6.09e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 16 KYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAV 95
Cdd:PRK06767 3 KKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 96 SSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSV 175
Cdd:PRK06767 83 GSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 176 LDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVivdggkfdwnspkfpgfitpdas 255
Cdd:PRK06767 163 IDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGV----------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 256 yhdlvyaeAIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEvps 335
Cdd:PRK06767 220 --------TICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE--- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 336 hpqVKEASKYLPKGaGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIR 415
Cdd:PRK06767 289 ---GELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIR 364
|
410 420
....*....|....*....|
gi 2225629504 416 LSIGIEHIDDILNDLEQAIE 435
Cdd:PRK06767 365 LSVGLESWEDIVSDLEQALK 384
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
18-434 |
2.19e-107 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 323.61 E-value: 2.19e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLtGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:PRK07810 15 SQATIGVRGGLLRSGF-EETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLD 177
Cdd:PRK07810 94 GMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 178 IEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfitpdasyh 257
Cdd:PRK07810 174 IAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAI------------------------ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 258 dlvyaeaIGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHP 337
Cdd:PRK07810 230 -------LGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 338 QVKEASKYLpKGAGAVVVFGIAGGRESGKK----LINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDL 413
Cdd:PRK07810 303 QYDLAKRQM-SGGGTVVTFELDAPEDAAKKrafeVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGV 381
|
410 420
....*....|....*....|.
gi 2225629504 414 IRLSIGIEHIDDILNDLEQAI 434
Cdd:PRK07810 382 VRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
15-435 |
6.71e-100 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 303.16 E-value: 6.71e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 15 NKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDhaanlfalQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLA 94
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIG--------ESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 95 VSSGMAAITTaILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLS 174
Cdd:PRK08247 73 CSSGMAAIQL-VMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 175 VLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKfdwnspkfpgfitpda 254
Cdd:PRK08247 152 ETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ---------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 255 syhdlvyaEAIGTAAYIVKArvqllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPevp 334
Cdd:PRK08247 216 --------ELCERLAYYQNA-------AGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP--- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 335 shpqvkeaskylpkGAGAVVVFgiaggRESGKKLIN----SVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVS 410
Cdd:PRK08247 278 --------------GRGGMLSF-----RLQDEEWVNpflkSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVC 338
|
410 420
....*....|....*....|....*
gi 2225629504 411 EDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK08247 339 NRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
18-435 |
1.66e-98 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 300.10 E-value: 1.66e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDtdhaanlfALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:PRK07671 2 RAKTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEA--------VGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITtAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLD 177
Cdd:PRK07671 74 GMAAIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 178 IEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasyh 257
Cdd:PRK07671 153 IKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV----------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 258 dlVYAEAIGTAAYIVKARVqllrdlGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHP 337
Cdd:PRK07671 210 --VNSPELAEDLHFVQNST------GGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 338 QvKEASKYLPKGAGAVVVFGIaGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLS 417
Cdd:PRK07671 282 N-HELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRIS 359
|
410
....*....|....*...
gi 2225629504 418 IGIEHIDDILNDLEQAIE 435
Cdd:PRK07671 360 VGIEDGEDLIEDLAQALA 377
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
35-437 |
7.01e-98 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 298.91 E-value: 7.01e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 35 GARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGD 114
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 115 EIVSSSSLYGGTYNLFDTtLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHEAGIPLII 194
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFGT-LRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 195 DNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDWNspKFPGfITPDasyhdlvYAEAIGTAAYIVKA 274
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWS--AYPN-IFPA-------YRKGDPQQWGLTQI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 275 RVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQVKEASKYLpKGAGAVV 354
Cdd:PRK05939 237 RKKGLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELF-RHYGGLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 355 VFGIAGGrESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIGIEHIDDILNDLEQAI 434
Cdd:PRK05939 316 SFELADG-IDCFDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQAL 394
|
...
gi 2225629504 435 EVA 437
Cdd:PRK05939 395 DAT 397
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
12-440 |
8.39e-95 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 291.26 E-value: 8.39e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 12 EGTNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVG 91
Cdd:PRK08249 2 MDFNNAGVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 92 SLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNP 171
Cdd:PRK08249 82 ATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 172 SLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdGGKfdwnspkfpgfit 251
Cdd:PRK08249 162 TLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC-GSK------------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 252 pdasyhDLVyaeaigtaayivkARVQLLRDL-GVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLY 330
Cdd:PRK08249 228 ------ELM-------------EQVYHYREInGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYY 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 331 PEVPSHPQvKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGdSKSLIIHPASTT-HQQLTADQLKEAGV 409
Cdd:PRK08249 289 PGLETHPN-HEIAKAQMRGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLG-AVETIYGPARTTsHVENTLEERAALGI 366
|
410 420 430
....*....|....*....|....*....|.
gi 2225629504 410 SEDLIRLSIGIEHIDDILNDLEQAIEVATGQ 440
Cdd:PRK08249 367 PEGLVRISVGIEDTEDLIADLEQAFAHLESE 397
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
18-436 |
5.69e-89 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 275.79 E-value: 5.69e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLtGARALPIYMSNAYQFKDTDHaanlfaLQEPG--YIYTRIHNPTVSVFEERVAQLEGGVGSLAV 95
Cdd:PRK08574 2 RRGTDAVRGYRGSDPY-GSLQPPIYLTALFRQEGEAY------PSDRGfdLKYSREENPTLRPLEEALAKLEGGVDALAF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 96 SSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTtLPRYGIKTTFVDQSNpENFRQAIT-PHTKAIYAETIGNPSLS 174
Cdd:PRK08574 75 NSGMAAISTLFFSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLAYPST-EDIIEAIKeGRTKLVFIETMTNPTLK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 175 VLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDGGKFDwnspkfpgfitpda 254
Cdd:PRK08574 153 VIDVPEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEF-------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 255 sYHDLvyaeaigtaaYIVKARvqllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVP 334
Cdd:PRK08574 219 -LEEL----------WEWRRR------LGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 335 SHPQVKEASKYLPKGA-GAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDL 413
Cdd:PRK08574 282 SDPYHGVAKRLFGKDLyGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDL 361
|
410 420
....*....|....*....|...
gi 2225629504 414 IRLSIGIEHIDDILNDLEQAIEV 436
Cdd:PRK08574 362 VRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
17-444 |
5.30e-85 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 265.87 E-value: 5.30e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 17 YRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANlfalqepgYIYTRIHNPTVSVFEERVAQLEGGVGSLAVS 96
Cdd:PRK08064 5 YSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGK--------YDYSRSGNPTREALEDIIAELEGGTKGFAFA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 97 SGMAAITTAILNIAgSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVL 176
Cdd:PRK08064 77 SGMAAISTAFLLLS-KGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 177 DIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasy 256
Cdd:PRK08064 156 DIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAV---------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 257 hdlVYAEAIGTAAYivkarvQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSH 336
Cdd:PRK08064 214 ---VKDEELAQKLY------FLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTH 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 337 P----QVKEASkylpkGAGAVVVFGIAgGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSED 412
Cdd:PRK08064 285 LgfdiQQSQAT-----SAGAVLSFTLQ-SEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDG 358
|
410 420 430
....*....|....*....|....*....|..
gi 2225629504 413 LIRLSIGIEHIDDILNDLEQAIEVATGQKSAS 444
Cdd:PRK08064 359 LLRLSVGLENVDDLIADFEQALSYVEEPVNAK 390
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
18-435 |
1.34e-84 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 264.45 E-value: 1.34e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKdtdhaanlfALQEP-GYIYTRIHNPTVSVFEERVAQLEGGVGSLAVS 96
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQD---------AIGRPkGYEYSRSGNPTRFALEELIADLEGGVKGFAFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 97 SGMAAITtAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVL 176
Cdd:PRK06176 73 SGLAGIH-AVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKIT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 177 DIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDggkfdwNSPKFpgfitpdasy 256
Cdd:PRK06176 152 DLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTT------NNEAL---------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 257 hdlvyAEAIGTaayivkarvqLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSH 336
Cdd:PRK06176 216 -----AQEIAF----------FQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTH 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 337 PQVKEASKYLpKGAGAVVVFGIAGGRESgKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRL 416
Cdd:PRK06176 281 PNHELAKKQM-RGFSGMLSFTLKNDSEA-VAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRL 358
|
410
....*....|....*....
gi 2225629504 417 SIGIEHIDDILNDLEQAIE 435
Cdd:PRK06176 359 SVGIEHEQDLLEDLEQAFA 377
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
31-434 |
3.20e-83 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 260.53 E-value: 3.20e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 31 DPLTGARALPIYMSNAYQFKDTDHaanlfalqepgYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIA 110
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYPEGEK-----------YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 111 GSGDEIVSSSSLYGGTYNLFDTTLPRYGIKttfVDQSNPEN---FRQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHE 187
Cdd:PRK06460 82 KPGNSVLVHRDMFGRSYRFFTDYLKNWGVN---VDASNPGSdniIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 188 AGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfitpdASYHDLVyaeaigt 267
Cdd:PRK06460 159 NGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA--------------------AGYGKLL------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 268 aayivKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQVKEASKYLp 347
Cdd:PRK06460 212 -----NVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVL- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 348 KGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIGIEHIDDIL 427
Cdd:PRK06460 286 KGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLI 365
|
....*..
gi 2225629504 428 NDLEQAI 434
Cdd:PRK06460 366 EDLDRAL 372
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
19-437 |
6.63e-83 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 259.76 E-value: 6.63e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 19 LETIGVHGGLQPDPLtGARALPIYMSNAyqFKDTDhaanlfALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSG 98
Cdd:TIGR01329 1 LSTLLVNTDNKNDPY-DASSMPIYQTAT--FKQPL------AIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 99 MAAITTaILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDI 178
Cdd:TIGR01329 72 MAALDV-ITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 179 EAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasyhd 258
Cdd:TIGR01329 151 RKISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLA------------------------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 259 lVYAEAIGTAAYIvkarvqLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQ 338
Cdd:TIGR01329 207 -VKGEEIAKKVYF------LQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 339 VKeASKYLPKGAGAVVVFgIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSI 418
Cdd:TIGR01329 280 FH-LHFSQAKGAGSVLSF-ETGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSV 357
|
410
....*....|....*....
gi 2225629504 419 GIEHIDDILNDLEQAIEVA 437
Cdd:TIGR01329 358 GIEDVDDLISDLDIAFVTA 376
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
18-441 |
3.12e-78 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 248.27 E-value: 3.12e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 18 RLETIGVHGGLQPDPLTGARALPIYMSNAYQFKdtdhaanlfALQE-PGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVS 96
Cdd:PRK08861 5 KPATIAVRTGIESDSQYHAVVPPIYLSTNYGFP---------AFGEvPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 97 SGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVL 176
Cdd:PRK08861 76 CGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 177 DIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfITPDASY 256
Cdd:PRK08861 156 DIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVL----------------ITKTKEH 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 257 HDLV--YAEAIGTAAyivkarvqllrdlgvsiSPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVP 334
Cdd:PRK08861 220 AEELawWGNCIGATG-----------------TPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLP 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 335 SHPQvKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLI 414
Cdd:PRK08861 283 EHPG-HEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLL 361
|
410 420
....*....|....*....|....*..
gi 2225629504 415 RLSIGIEHIDDILNDLEQAIEVATGQK 441
Cdd:PRK08861 362 RLSVGLEDAQDLIADLDQAFAKAAEAN 388
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
21-437 |
3.25e-76 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 242.88 E-value: 3.25e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 21 TIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDhaanlfalQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMA 100
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEA 180
Cdd:PRK08045 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 181 VATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnsPKFPGFITPDASYHDlv 260
Cdd:PRK08045 159 ICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------AKDPDVVTELAWWAN-- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 261 yaeaigtaayivkarvqllrDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQVK 340
Cdd:PRK08045 228 --------------------NIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 341 EASKYlPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIGI 420
Cdd:PRK08045 288 IAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGI 366
|
410
....*....|....*..
gi 2225629504 421 EHIDDILNDLEQAIEVA 437
Cdd:PRK08045 367 EDGEDLIADLENGFRAA 383
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
21-443 |
9.21e-76 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 242.20 E-value: 9.21e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 21 TIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANlfalqepgYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMA 100
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQ--------YDYTRSGNPTRDLLGEALAELEGGAGGVITATGMG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEA 180
Cdd:PRK08776 87 AINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 181 VATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfpgfITPDASYHDLV 260
Cdd:PRK08776 167 VIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAV----------------VARDAELHQQL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 261 --YAEAigtaayivkarvqllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQ 338
Cdd:PRK08776 231 vwWANA-----------------LGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 339 VKEASKYlPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSI 418
Cdd:PRK08776 294 HALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSV 372
|
410 420
....*....|....*....|....*
gi 2225629504 419 GIEHIDDILNDLEQAIEVATGQKSA 443
Cdd:PRK08776 373 GIESAEDLLIDLRAGLARAEAVLTA 397
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
14-435 |
1.89e-75 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 240.11 E-value: 1.89e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 14 TNKYRLETIGVHGGLQPDPLTGARALPIYMSNAYQFKDtdhaanlFAlQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSL 93
Cdd:PRK07269 2 SKDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPE-------FG-QSTGFDYTRTKNPTRAKLEETLAAIESADYAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 94 AVSSGMAAITTAiLNIAGSGDEIVSSSSLYGGTYNLFDTTlPRYGiKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSL 173
Cdd:PRK07269 74 ATSSGMSAIVLA-FSVFPVGSKVVAVRDLYGGSFRWFNQQ-EKEG-RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLM 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 174 SVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVDggkfdwNSPKFpgfitpd 253
Cdd:PRK07269 151 VEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVT------NDLEL------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 254 asYHDLVYAeaigtaayivkarvqlLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPev 333
Cdd:PRK07269 218 --YEKLFYN----------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT-- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 334 pshpqvkeaskylpkGAGAVVVFGIAgGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDL 413
Cdd:PRK07269 278 ---------------GKGGMISFKVA-DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDL 341
|
410 420
....*....|....*....|..
gi 2225629504 414 IRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK07269 342 LRLSIGIEDARDLIADLKQALE 363
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
21-434 |
4.39e-74 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 237.49 E-value: 4.39e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 21 TIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMA 100
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTF--VDQSNPENFRQAitpHTKAIYAETIGNPSLSVLDI 178
Cdd:PRK06434 91 AITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYidTDRLNSLDFDPS---NYDLIYAESITNPTLKVPDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 179 EAVATIAHEAGIplIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVivdggkfdwnspkfpgFITPDASYHD 258
Cdd:PRK06434 168 KNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGV----------------AGTNNKSIFN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 259 LVyaeaigtaayivkarVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVpshpq 338
Cdd:PRK06434 230 NL---------------VERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT----- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 339 vkEASKYLPKGAGAVVVFGIAGGRESgKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSI 418
Cdd:PRK06434 290 --EIGKKVLRGFGGMLSFELRSMEDV-HKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSI 366
|
410
....*....|....*.
gi 2225629504 419 GIEHIDDILNDLEQAI 434
Cdd:PRK06434 367 GIEDIDDLIKDIENAL 382
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
20-437 |
2.51e-71 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 231.48 E-value: 2.51e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 20 ETIGVHGGLQPDPLTGARALPIYMSNAYQFKDTDHAANLF----ALQEP------GYIYTRIHNPTVSVFEERVAQLEGG 89
Cdd:PRK07049 19 ETQMLNYGYDPELSEGAVKPPVFLTSTFVFRSAEDGRDFFdyvsGRKEPpagegaGLVYSRFNHPNSEIVEDRLAVYEGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 90 VGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTT-FVDQSNPENFRQAITP-----HTKAI 163
Cdd:PRK07049 99 ESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVgFADGLSEAAIGAAAEAaaakgRVSLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 164 YAETIGNPSLSVLDIEAVATIAHEAG-----IPLI-IDNTFATPYLCRPIEHGADIVVHSATKWLlgngttlggvivdGG 237
Cdd:PRK07049 179 LIETPANPTNSLVDVAAVRRVADAIEarqghRPIIaCDNTLLGPVFQKPLEHGADLSVYSLTKYV-------------GG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 238 kfdwnspkfpgfitpdasYHDLVYAEAIGTAAYIvkARVQLLRD-LGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVV 316
Cdd:PRK07049 246 ------------------HSDLVAGAVLGRKALI--RQVRALRSaIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 317 QYLENHPAVDWVLY-PEVPSHPQVKEASKYLPKGAGAVVVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTT 395
Cdd:PRK07049 306 EFLRDHPKVEKLHYlPFLDPDSAYGAVYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMT 385
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2225629504 396 HQQLTADQLKEAGVSEDLIRLSIGIEHIDDILNDLEQAIEVA 437
Cdd:PRK07049 386 HSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
10-438 |
3.84e-70 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 227.27 E-value: 3.84e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 10 MGEGTNKY-RLETIGVHGglQPDPLtGARALPIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLEG 88
Cdd:PRK05968 1 MNDGLDPFdLAALITAHD--EGNAF-DAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 89 GVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAItPHTKAIYAEti 168
Cdd:PRK05968 78 AEDARGFASGMAAISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLE-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 169 gNPSLSVL---DIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspk 245
Cdd:PRK05968 155 -SPTSWVFelqDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA----------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 246 fpgfitpdasyhdlvyaeaiGTAAYIVKARVQLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAV 325
Cdd:PRK05968 223 --------------------GSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 326 DWVLYPEVPSHPqvkeasKYLPKGAGAVVVFGIAGGRESgKKLINSVKLWSHVANVGDSKSLIIhPASTTHQQltADQLK 405
Cdd:PRK05968 283 ERVCHPALANHP------PAGLSGTSGLFSFIFREGIDV-RAFADALKLFRLGVSWGGHESLVV-PAEVVLQQ--KAQPN 352
|
410 420 430
....*....|....*....|....*....|....*.
gi 2225629504 406 EA---GVSEDLIRLSIGIEHIDDILNDLEQAIEVAT 438
Cdd:PRK05968 353 SAarfGVSPRSVRLHVGLEGTEALWADLEQALAAAS 388
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
31-434 |
2.53e-67 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 222.21 E-value: 2.53e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 31 DPLTgARALPIYMSNAyqFKDTDhaanlfALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITtAILNIA 110
Cdd:PLN02509 99 DPFD-AMSTPLYQTAT--FKQPS------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 111 GSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHEAGI 190
Cdd:PLN02509 169 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGA 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 191 PLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfitpdasyhdlVYAEAIGTAAY 270
Cdd:PLN02509 249 LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLA-------------------------VKGEKLAKEVY 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 271 IvkarvqLLRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQvKEASKYLPKGA 350
Cdd:PLN02509 304 F------LQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPG-HHLHFSQAKGA 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 351 GAVVVFgIAGGRESGKKLINSVKLWSHVANVGDSKSLIIHPASTTHQQLTADQLKEAGVSEDLIRLSIGIEHIDDILNDL 430
Cdd:PLN02509 377 GSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDL 455
|
....
gi 2225629504 431 EQAI 434
Cdd:PLN02509 456 DIAF 459
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
23-420 |
1.91e-60 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 202.69 E-value: 1.91e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 23 GVHGGLQpdpltgaraLPIYMSNAYQFKDTDHAANLFAlQEPG-----YIYTRIHNPTVSVFEERVAQLEGGVGSLAVSS 97
Cdd:PLN02242 30 GEHGGVN---------MSIEASATFTVMEPDTMRRMFS-GELGpdrdfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTAS 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 98 GMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPR-YGIKTTFVDQSNPENFRQAITP-HTKAIYAETIGNPSLSV 175
Cdd:PLN02242 100 GMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 176 LDIEAVATIAHEAGIPLIIDNTFAtPYLCRPIEHGADIVVHSATKWLLGngttlGGVIVDGgkfdwnspkfpgfitpdas 255
Cdd:PLN02242 180 ADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISG-----GADIIAG------------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 256 yhdlvyaeAIGTAAYIVKARVQL----LRDLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVdwVLYP 331
Cdd:PLN02242 235 --------AVCGPAELVNSMMDLhhgaLMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGLK--VIYP 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 332 EVPSHPQVKEASKYLPKGAGAVVVFGI-AGGRESGKKLINSVKLWSH----VANVGDSKSLIIHPASTTHQQLTADQLKE 406
Cdd:PLN02242 305 GLEDHPQHALLKSMANKGYGFGGLLCLdMDTEERANRLMRYLQNSTQfgfmAVSLGYYETLMSCSGSSTSSELDPEEKAA 384
|
410
....*....|....
gi 2225629504 407 AGVSEDLIRLSIGI 420
Cdd:PLN02242 385 AGISPGLVRMSVGY 398
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
24-437 |
1.41e-51 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 177.88 E-value: 1.41e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 24 VHGGLqPDPLTGAR-ALPIYMSNAYQFKDTDHAAnlfalqepGYIYTRIHNPTVSVFEERVAQLEGGvGSLAVSSGMAAI 102
Cdd:PRK07582 9 VHAGG-PEAVPGEPvLPGPVFAAPYHLSPGEPTG--------PDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 103 TTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKttfVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVA 182
Cdd:PRK07582 79 TAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVT---VREAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 183 TIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIVdggkfdwnspkfpgfiTPDASyhdlvya 262
Cdd:PRK07582 156 AAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVA----------------GRDPE------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 263 eaigtaayiVKARVQLLRDLGVSI-SPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQVKE 341
Cdd:PRK07582 213 ---------LMAAVERWRLLAGAIpGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 342 ASKYLpKGAGAVVVFGIAgGRESGKKLINSVKLWSHVANVGDsksliIHPastthqqlTADQLKEAG--VSEDLIRLSIG 419
Cdd:PRK07582 284 AARQM-RRFGGLVSFELA-DAAAAERFVAASRLVVAATSFGG-----VHT--------SADRRARWGdaVPEGFVRLSCG 348
|
410
....*....|....*...
gi 2225629504 420 IEHIDDILNDLEQAIEVA 437
Cdd:PRK07582 349 IEDTDDLVADLERALDAL 366
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
25-439 |
5.57e-51 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 177.31 E-value: 5.57e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 25 HGGLQPDPLTGARALPIYMSNAYQFKDtdhaANLFALQEPGYIYTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITT 104
Cdd:PRK05967 19 HDGNDPGDYHGFVNPPVVHASTVLFPD----AETMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 105 AILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVATI 184
Cdd:PRK05967 95 PFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 185 AHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLggvivdggkfdwnspkfPGFITPDASYHDLVYaEA 264
Cdd:PRK05967 175 AHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDIL-----------------LGTVSANEKCWPQLL-EA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 265 IGTaayivkarvqllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDWVLYPEVPSHPQvKEASK 344
Cdd:PRK05967 237 HGT--------------LGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPG-HEIWK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 345 YLPKGAGAVVVFGIAGGRESGKK----LINSVKLWSHVANVGDSKSLIIhpasttHQQLTADQLKEAGVSEDLIRLSIGI 420
Cdd:PRK05967 302 RDFSGASGIFSFVLAAGPEKGKAkahaFLDALEIFGLGYSWGGYESLAL------HVKLGDRTVAKAPYAGPVIRLQIGL 375
|
410
....*....|....*....
gi 2225629504 421 EHIDDILNDLEQAIEVATG 439
Cdd:PRK05967 376 EDVPDLKADLERGFAAASA 394
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
68-435 |
2.70e-48 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 169.91 E-value: 2.70e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 68 YTRIHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQS 147
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 148 NPENFRQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGT 227
Cdd:PRK09028 135 IGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 228 TLGGVIVDGGKFdWNSPKfpgfitpDASYHdlvyaeaigtaayivkarvqllrdLGVSISPFNAYQFSLGLETLHVRMKE 307
Cdd:PRK09028 215 VMLGTATANEKH-WDQLR-------EHSYL------------------------MGQCTSPDDVYLAMRGLRTLGVRLAQ 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 308 HIANTRKVVQYLENHPAVDWVLYPEVPSHPQvKEASKYLPKGAGAVVVFGI-AGGRESGKKLINSVKLWSHVANVGDSKS 386
Cdd:PRK09028 263 HEKNALKVANWLATRPEVDHVRHPAFETCPG-HEFFKRDFSGSNGLFSFVLkQGDPKAVTALVEGMQHFKMGFSWGGFES 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2225629504 387 LIIHPASTthqqltaDQLKEAG---VSEDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK09028 342 LILGVFGI-------NKLRTATnwdFSKPLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
10-435 |
7.19e-40 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 147.18 E-value: 7.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 10 MGEGTNKYRLETIGVHGGLQPDPltGARAL--PIYMSNAYQFKDTDHAANLFALQEPGYIYTRIHNPTVSVFEERVAQLE 87
Cdd:PRK07050 1 MTASTPKRALQTRIVQPDDQIPP--GFRSFvtPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 88 GGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITPHTKAIYAET 167
Cdd:PRK07050 79 GGRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 168 IGNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGTTLGGVIvdggkfdwnspkfp 247
Cdd:PRK07050 159 PGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGAT-------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 248 gfITPDASYHDLVYAeaigtaayivkARVQllrdLGVSISPFNAYQFSLGLETLHVRMKEHIANTRKVVQYLENHPAVDW 327
Cdd:PRK07050 225 --ITADAELHAKLKL-----------ARMR----LGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIAT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 328 VLYPEVPSHPQVKEASKYLpKGAGAV--VVFGIAGGRESGKKLINSVKLWSHVANVGDSKSLIIhPASTTHqqLTADQLK 405
Cdd:PRK07050 288 VLHPALPDCPGHAFWMRDF-TGAGGLfsVVFDERYSPAQVDAFVEALELFAIGWSWGGACSLAM-PYDVAS--MRTAKWP 363
|
410 420 430
....*....|....*....|....*....|
gi 2225629504 406 EAGvseDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK07050 364 HRG---TLVRLYIGLEDEADLIADLEQALE 390
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
79-435 |
1.52e-32 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 127.13 E-value: 1.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 79 FEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTTLPRYGIKTTFVDQSNPENFRQAITP 158
Cdd:PRK08114 67 LQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQP 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 159 HTKAIYAETIGNPSLSVLDI----EAVATIAHEAGIplIIDNTFATPYLCRPIEHGADIVVHSATKWLLGNGttlggviv 234
Cdd:PRK08114 147 NTKVVFLESPGSITMEVHDVpaivAAVRSVNPDAVI--MIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHS-------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 235 dggkfdwnspkfpgfitpDAsyhdlvyaeAIGTAayIVKARV--QLLRD---LGVSISPFNAYQFSLGLETLHVRMKEHI 309
Cdd:PRK08114 217 ------------------DA---------MIGTA--VANARCweQLRENsylMGQMVDADTAYMTSRGLRTLGVRLRQHE 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 310 ANTRKVVQYLENHPAVDWVLYPEVPSHPQvKEASKYLPKGAGAVVVFgiaggrESGKKL--------INSVKLWSHVANV 381
Cdd:PRK08114 268 ESSLKVAEWLAEHPEVARVNHPALPGCKG-HEFWKRDFTGSSGLFSF------VLKKKLtdeqlanyLDNFSLFSMAYSW 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2225629504 382 GDSKSLIIHpasTTHQQLTAdqLKEAG---VSEDLIRLSIGIEHIDDILNDLEQAIE 435
Cdd:PRK08114 341 GGFESLILA---NQPEEIAA--IRPAGevdFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
79-235 |
6.39e-19 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 83.59 E-value: 6.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 79 FEERVAQL--EGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSLYGGTYNLFDTtlpRYGIKTTFVDQSNPENF---- 152
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAE---LAGAKPVPVPVDDAGYGgldv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 153 ----RQAITPHTKAIYAETIGNPSLSVLDIEAVATIAHEAGIPLIIDNTFATPY----LCRPIEHGADIVVHSATKWLLG 224
Cdd:cd01494 82 aileELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGG 161
|
170
....*....|.
gi 2225629504 225 NGTtlGGVIVD 235
Cdd:cd01494 162 EGG--GVVIVK 170
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
71-220 |
7.88e-12 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 66.54 E-value: 7.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 71 IHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNI-AGSGDEIVSSSSLYGGTYNlfdtTLPRYGIKTTFVD---- 145
Cdd:pfam01041 21 TTGPYVREFERAFAAYLGVKHAIAVSSGTAALHLALRALgVGPGDEVITPSFTFVATAN----AALRLGAKPVFVDidpd 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 146 --QSNPENFRQAITPHTKAIY-AETIGNPSlsvlDIEAVATIAHEAGIPLIID--NTFATPYLCRPIEHGADIVVHS--A 218
Cdd:pfam01041 97 tyNIDPEAIEAAITPRTKAIIpVHLYGQPA----DMDAIRAIAARHGLPVIEDaaHALGATYQGKKVGTLGDAATFSfhP 172
|
..
gi 2225629504 219 TK 220
Cdd:pfam01041 173 TK 174
|
|
| PRK11658 |
PRK11658 |
UDP-4-amino-4-deoxy-L-arabinose aminotransferase; |
65-234 |
8.56e-12 |
|
UDP-4-amino-4-deoxy-L-arabinose aminotransferase;
Pssm-ID: 183263 Cd Length: 379 Bit Score: 66.20 E-value: 8.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 65 GYIYTrihNPTVSVFEERVAQLEGGVGSLAVSSGMAA--ITTAILNIaGSGDEIVSSSSLYGGTYNLFdtTLprYGIKTT 142
Cdd:PRK11658 27 GWITT---GPKNQALEQAFCQLTGNQHAIAVSSATAGmhITLMALGI-GPGDEVITPSLTWVSTLNMI--VL--LGATPV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 143 FVD------QSNPENFRQAITPHTKAI----YAetiGNPslsvLDIEAVATIAHEAGIPLIIDNTFA--TPYLCRPI-EH 209
Cdd:PRK11658 99 MVDvdrdtlMVTPEAIEAAITPRTKAIipvhYA---GAP----ADLDAIRAIGERYGIPVIEDAAHAvgTYYKGRHIgAR 171
|
170 180
....*....|....*....|....*.
gi 2225629504 210 GADIVVHSATKwllgNGTTL-GGVIV 234
Cdd:PRK11658 172 GTAIFSFHAIK----NITCAeGGLVV 193
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
71-196 |
2.71e-10 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 61.62 E-value: 2.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 71 IHNPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAI--LNIaGSGDE-IVSSsslyggtYNLFDTTLP--RYGIKTTFVD 145
Cdd:COG0399 27 TLGPEVKEFEEEFAAYLGVKHAVAVSSGTAALHLALraLGI-GPGDEvITPA-------FTFVATANAilYVGATPVFVD 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2225629504 146 qSNPENF-------RQAITPHTKAI----YAetiGNPSlsvlDIEAVATIAHEAGIPLIIDN 196
Cdd:COG0399 99 -IDPDTYnidpealEAAITPRTKAIipvhLY---GQPA----DMDAIMAIAKKHGLKVIEDA 152
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
74-196 |
1.16e-08 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 56.40 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 74 PTVSVFEERVAQLEGGVGSLAVSSGMAAITTAI--LNIaGSGDEIVSSSSLYGGTYNlfdtTLPRYGIKTTFVD------ 145
Cdd:cd00616 18 PKVREFEKAFAEYLGVKYAVAVSSGTAALHLALraLGI-GPGDEVIVPSFTFVATAN----AILLLGATPVFVDidpdty 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2225629504 146 QSNPENFRQAITPHTKAI----YAetiGNPSlsvlDIEAVATIAHEAGIPLIIDN 196
Cdd:cd00616 93 NIDPELIEAAITPRTKAIipvhLY---GNPA----DMDAIMAIAKRHGLPVIEDA 140
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
81-198 |
1.94e-05 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 46.49 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 81 ERVAQLEGGV---GSLAVSSGM-AAITTAILNIAGSGDEIVSSSSLYggtynlFD--TTLPRYGIKTTFVDQS------- 147
Cdd:PRK07550 78 AHYSRLYGAAispEQVHITSGCnQAFWAAMVTLAGAGDEVILPLPWY------FNhkMWLDMLGIRPVYLPCDegpgllp 151
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2225629504 148 NPENFRQAITPHTKAIYAETIGNPSLSVLD---IEAVATIAHEAGIPLIIDNTF 198
Cdd:PRK07550 152 DPAAAEALITPRTRAIALVTPNNPTGVVYPpelLHELYDLARRHGIALILDETY 205
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
73-234 |
4.19e-05 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 45.28 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 73 NPTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSslygGTYNLFDTTlpRY-----GIKTTFVDQS 147
Cdd:pfam01212 31 DPTVNRLEDRVAELFGKEAALFVPSGTAANQLALMAHCQRGDEVICGE----PAHIHFDET--GGhaelgGVQPRPLDGD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 148 N-----PENFRQAITPHTKAIYAET-----------IGNPSLSVLDIEAVATIAHEAGIPLIID------NTFATPYLCR 205
Cdd:pfam01212 105 EagnmdLEDLEAAIREVGADIFPPTglislenthnsAGGQVVSLENLREIAALAREHGIPVHLDgarfanAAVALGVIVK 184
|
170 180
....*....|....*....|....*....
gi 2225629504 206 PIEHGADIVVHSATKWLLGNgttLGGVIV 234
Cdd:pfam01212 185 EITSYADSVTMCLSKGLGAP---VGSVLA 210
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
44-199 |
1.32e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 43.83 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 44 SNAY---QFKDTDHAANLFALQEPGYIYTRIHNPTVsvFEERVAQLEGG--------VGSLAVSSGM-AAITTAILNIAG 111
Cdd:pfam00155 8 SNEYlgdTLPAVAKAEKDALAGGTRNLYGPTDGHPE--LREALAKFLGRspvlkldrEAAVVFGSGAgANIEALIFLLAN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 112 SGDEIVSSSslygGTYNLFDTTLPRYGIKTTFVDQSNPENFR-------QAITPHTKAIYAETIGNPSLSVL---DIEAV 181
Cdd:pfam00155 86 PGDAILVPA----PTYASYIRIARLAGGEVVRYPLYDSNDFHldfdaleAALKEKPKVVLHTSPHNPTGTVAtleELEKL 161
|
170
....*....|....*...
gi 2225629504 182 ATIAHEAGIPLIIDNTFA 199
Cdd:pfam00155 162 LDLAKEHNILLLVDEAYA 179
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
80-241 |
1.46e-04 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 43.96 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 80 EERVAQLEGGVGSLAVSSGMAAITTAiLNIAGSGDE-IVSSSSL--YGGTYNLfDTTLPRYGIKTTFVDQSN---PENFR 153
Cdd:COG1921 71 EELLCELTGAEAALVVNNNAAAVLLA-LAALAAGKEvIVSRGELveIGGSFRI-PDVMALSGAKLVEVGTTNrthLRDYE 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 154 QAITPHTKAI-------YAetIGNPSLSVlDIEAVATIAHEAGIPLIID------------NTFATPYLCRPIEHGADIV 214
Cdd:COG1921 149 AAITENTAALlkvhtsnYR--IVGFTEEV-SLAELAELAHEHGLPVIVDlgsgslvdlskyGLPHEPTVQEYLAAGADLV 225
|
170 180
....*....|....*....|....*..
gi 2225629504 215 VHSATKwLLGnGTTlGGVIVdgGKFDW 241
Cdd:COG1921 226 TFSGDK-LLG-GPQ-AGIIV--GKKEL 247
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
79-365 |
1.60e-04 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 43.48 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 79 FEERVAQLEGGVGSLAV--------SSGMAAITTAILNIAGSGDEIVSSSSlyggTYNLFDTTLPRYGIKTTFV------ 144
Cdd:cd00609 41 LREAIAEWLGRRGGVDVppeeivvtNGAQEALSLLLRALLNPGDEVLVPDP----TYPGYEAAARLAGAEVVPVpldeeg 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 145 -DQSNPENFRQAITPHTKAIYAETIGNPSLSVLD---IEAVATIAHEAGIPLIIDNT---FATPYLCRPIEHGAD----- 212
Cdd:cd00609 117 gFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLSeeeLEELAELAKKHGILIISDEAyaeLVYDGEPPPALALLDayerv 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 213 IVVHSATKwllgngtTLGgvivdggkfdwnspkFPGFITpdaSYhdlvyaeAIGTAAYIVKARVQLLRDLGVSISPFNAY 292
Cdd:cd00609 197 IVLRSFSK-------TFG---------------LPGLRI---GY-------LIAPPEELLERLKKLLPYTTSGPSTLSQA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 293 QFSLGLETLH---VRMKEHIANTR-KVVQYLENHPAVDWV-------LYPEVPSHPQVKEASKYLPKGAGAVVVFGIAGG 361
Cdd:cd00609 245 AAAAALDDGEehlEELRERYRRRRdALLEALKELGPLVVVkpsggffLWLDLPEGDDEEFLERLLLEAGVVVRPGSAFGE 324
|
....
gi 2225629504 362 RESG 365
Cdd:cd00609 325 GGEG 328
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
103-269 |
3.33e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 42.82 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 103 TTAILNIA-------GSGDEIVSSSSLYGGtyNLfdttLP------RYGIKTTFVD-----QSNPENFRQAITPHTKAIy 164
Cdd:COG0520 86 TTEAINLVayglgrlKPGDEILITEMEHHS--NI----VPwqelaeRTGAEVRVIPldedgELDLEALEALLTPRTKLV- 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 165 aetignpSLS--------VLDIEAVATIAHEAGIPLIIDNTFATPYLcrPI---EHGADIVVHSATK------------- 220
Cdd:COG0520 159 -------AVThvsnvtgtVNPVKEIAALAHAHGALVLVDGAQSVPHL--PVdvqALGCDFYAFSGHKlygptgigvlygk 229
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2225629504 221 ---------WLLGngttlGGVI--VDGGKFDWNSP--KF-PGfiTPDasyhdlvYAEAIGTAA 269
Cdd:COG0520 230 rellealppFLGG-----GGMIewVSFDGTTYADLprRFeAG--TPN-------IAGAIGLGA 278
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
93-196 |
4.33e-04 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 42.42 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 93 LAVSSGMAAITTAILNIAGSGDEIV----------SSSSLYGGTYNLFDTTlprygIKTTFvdQSNPENFRQAITPHTKA 162
Cdd:COG0436 94 LVTNGAKEALALALLALLNPGDEVLvpdpgypsyrAAVRLAGGKPVPVPLD-----EENGF--LPDPEALEAAITPRTKA 166
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2225629504 163 IYaetIGNPS------LSVLDIEAVATIAHEAGIPLIIDN 196
Cdd:COG0436 167 IV---LNSPNnptgavYSREELEALAELAREHDLLVISDE 203
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
101-195 |
7.22e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 41.76 E-value: 7.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDEIVSSSSLYGgTYNLFDTTLpryGIK----TTFVDQS----NPENFRQAITPHTKAIYAETIGNPS 172
Cdd:PRK07568 100 AILFAMMAICDPGDEILVPEPFYA-NYNGFATSA---GVKivpvTTKIEEGfhlpSKEEIEKLITPKTKAILISNPGNPT 175
|
90 100
....*....|....*....|....*.
gi 2225629504 173 LSVL---DIEAVATIAHEAGIPLIID 195
Cdd:PRK07568 176 GVVYtkeELEMLAEIAKKHDLFLISD 201
|
|
| PLN00175 |
PLN00175 |
aminotransferase family protein; Provisional |
93-185 |
9.65e-04 |
|
aminotransferase family protein; Provisional
Pssm-ID: 215089 [Multi-domain] Cd Length: 413 Bit Score: 41.39 E-value: 9.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 93 LAVSSGMA-AITTAILNIAGSGDEIVssssLYGGTYNLFDTTLPRYGIKTTFVDQSNP------ENFRQAITPHTKAIYA 165
Cdd:PLN00175 118 VTVTSGCTeAIAATILGLINPGDEVI----LFAPFYDSYEATLSMAGAKIKTVTLRPPdfavpeDELKAAFTSKTRAILI 193
|
90 100
....*....|....*....|
gi 2225629504 166 ETIGNPSLSVLDIEAVATIA 185
Cdd:PLN00175 194 NTPHNPTGKMFTREELELIA 213
|
|
| PRK08363 |
PRK08363 |
alanine aminotransferase; Validated |
94-198 |
1.68e-03 |
|
alanine aminotransferase; Validated
Pssm-ID: 181402 Cd Length: 398 Bit Score: 40.56 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 94 AVSSGMAAITTAILNiagSGDEIVssssLYGGTYNLFDTTLPRYGIKTTFVD-------QSNPENFRQAITPHTKAIYAE 166
Cdd:PRK08363 101 AVTEALQLIFGALLD---PGDEIL----IPGPSYPPYTGLVKFYGGVPVEYRtieeegwQPDIDDIRKKITEKTKAIAVI 173
|
90 100 110
....*....|....*....|....*....|....*
gi 2225629504 167 TIGNPSLSVLD---IEAVATIAHEAGIPLIIDNTF 198
Cdd:PRK08363 174 NPNNPTGALYEkktLKEILDIAGEHDLPVISDEIY 208
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
97-241 |
1.79e-03 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 40.47 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 97 SGMAAITTAILNIAGSGDEIVSsssLYGGTYnlfDT-------------TLPRYGIKTTFVD-----QSNPENFRQAITP 158
Cdd:COG4100 83 SGTHAIALALFGVLRPGDELLS---ITGKPY---DTleevigirgegqgSLKEFGISYRQVPltedgKIDLEAIKKAINE 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 159 HTKAI-------YAEtigNPSLSVLDIEAVATIAHEAGIPLII--DNtfatpylC--------RPIEHGADIVVHSatkw 221
Cdd:COG4100 157 KTKMVliqrsrgYSW---RPSLTIEEIGEIIKFVKSINPDVICfvDN-------CygefvetrEPTEVGADLMAGS---- 222
|
170 180
....*....|....*....|....
gi 2225629504 222 LLGN-GTTL---GGVIVdgGKFDW 241
Cdd:COG4100 223 LIKNpGGGLaptGGYIA--GRKDL 244
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
148-233 |
2.83e-03 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 39.54 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 148 NPENFRQAITPHTKAIYAeTIGNPSL--SVLDIEAVATIAHEAGIPLIIDNT------FATPYLCRPIEHGADIVVHSAT 219
Cdd:cd00615 141 PPETFKKALIEHPDAKAA-VITNPTYygICYNLRKIVEEAHHRGLPVLVDEAhgahfrFHPILPSSAAMAGADIVVQSTH 219
|
90
....*....|....
gi 2225629504 220 KwlLGNGTTLGGVI 233
Cdd:cd00615 220 K--TLPALTQGSMI 231
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
101-199 |
3.24e-03 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 101 AITTAILNIAGSGDE--IVSSS--------SLYGGTYNLFDTTlprygIKTTFvdQSNPENFRQAITPHTKAIYAETIGN 170
Cdd:PRK07682 93 ALDVAMRAIINPGDEvlIVEPSfvsyaplvTLAGGVPVPVATT-----LENEF--KVQPAQIEAAITAKTKAILLCSPNN 165
|
90 100 110
....*....|....*....|....*....|..
gi 2225629504 171 PSLSVL---DIEAVATIAHEAGIPLIIDNTFA 199
Cdd:PRK07682 166 PTGAVLnksELEEIAVIVEKHDLIVLSDEIYA 197
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
74-238 |
3.65e-03 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 39.24 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 74 PTVSVFEERVAQLEGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSSlygGTYNLFDTTLPRY--GIKTTFVDQSN--- 148
Cdd:cd06502 32 PTTAKLEARAAELFGKEAALFVPSGTAANQLALAAHTQPGGSVICHET---AHIYTDEAGAPEFlsGVKLLPVPGENgkl 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 149 -PENFRQAITPH-------TKAIYAE-TIGNPSLSVLD-IEAVATIAHEAGIPLIIDNT----FATPYLCRPIEH--GAD 212
Cdd:cd06502 109 tPEDLEAAIRPRddihfppPSLVSLEnTTEGGTVYPLDeLKAISALAKENGLPLHLDGArlanAAAALGVALKTYksGVD 188
|
170 180
....*....|....*....|....*.
gi 2225629504 213 IVVHSATKwllgNGTTLGGVIVDGGK 238
Cdd:cd06502 189 SVSFCLSK----GGGAPVGAVVVGNR 210
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
148-220 |
3.72e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 39.30 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 148 NPENFRQAITPHTKaiyaETIGNPSLSVL-----------DIEAVATIAHEAGIPLIIDNTFATPYLcrPI---EHGADI 213
Cdd:cd06452 121 TPEGYAEVIEEVKD----EFGKPPALALLthvdgnygnlhDAKKIAKVCHEYGVPLLLNGAYTVGRM--PVsgkELGADF 194
|
....*..
gi 2225629504 214 VVHSATK 220
Cdd:cd06452 195 IVGSGHK 201
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
149-195 |
5.81e-03 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 38.95 E-value: 5.81e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2225629504 149 PENFRQAITPHTKAIYAETIGNPSLSVL---DIEAVATIAHEAGIPLIID 195
Cdd:PRK05764 154 VEQLEAAITPKTKALILNSPSNPTGAVYspeELEAIADVAVEHDIWVLSD 203
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
82-195 |
6.30e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 38.43 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 82 RVAQLEGGVGSLAVSSGMAAITTAILNIAGSGDEIVSSSslYGGTYNLFDTTLPRYGIKTTFVDQS-----NPENFRQAI 156
Cdd:cd06451 43 YVFQTENGLTFLLSGSGTGAMEAALSNLLEPGDKVLVGV--NGVFGDRWADMAERYGADVDVVEKPwgeavSPEEIAEAL 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2225629504 157 TPHTKAIYAETIGNPSLSVL-DIEAVATIAHEAGIPLIID 195
Cdd:cd06451 121 EQHDIKAVTLTHNETSTGVLnPLEGIGALAKKHDALLIVD 160
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
145-231 |
9.48e-03 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 38.20 E-value: 9.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225629504 145 DQSNPENFRQAITPHTKAIYAEtigNPSL--SVLDIEAVATIAHEAGIPLIIdntFATP----YLCRPIEHGADIVV--- 215
Cdd:PRK00451 190 GVTDLEALEAAVDDDTAAVVVQ---YPNFfgVIEDLEEIAEIAHAGGALFIV---GVDPvslgLLKPPGEYGADIVVgeg 263
|
90
....*....|....*.
gi 2225629504 216 HSatkwlLGNGTTLGG 231
Cdd:PRK00451 264 QP-----LGIPLSFGG 274
|
|
| |
