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Conserved domains on  [gi|2225819928|ref|WP_245828567|]
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hydrogenase subunit MbhD domain-containing protein, partial [Solemya elarraichensis gill symbiont]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12507 super family cl26238
putative monovalent cation/H+ antiporter subunit B; Reviewed
 1-93 6.20e-18

putative monovalent cation/H+ antiporter subunit B; Reviewed


The actual alignment was detected with superfamily member PRK12507:

Pssm-ID: 237121 [Multi-domain]  Cd Length: 332  Bit Score: 75.85  E-value: 6.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225819928   1 MLLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGKRRREPRRRRt 80
Cdd:PRK12507   14 LILFLLILISIKIIFAKDLLNAVMLTSVFSLLIAVSFLIMDAPDVAMTEAAVGAGLSTCVYLNALKLTGRLKNIERTKI- 92

                          90
                  ....*....|...
gi 2225819928  81 LIPIIVVVLTGVT 93
Cdd:PRK12507   93 IPALLIVLLFGVT 105
 
Name Accession Description Interval E-value
PRK12507 PRK12507
putative monovalent cation/H+ antiporter subunit B; Reviewed
 1-93 6.20e-18

putative monovalent cation/H+ antiporter subunit B; Reviewed


Pssm-ID: 237121 [Multi-domain]  Cd Length: 332  Bit Score: 75.85  E-value: 6.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225819928   1 MLLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGKRRREPRRRRt 80
Cdd:PRK12507   14 LILFLLILISIKIIFAKDLLNAVMLTSVFSLLIAVSFLIMDAPDVAMTEAAVGAGLSTCVYLNALKLTGRLKNIERTKI- 92

                          90
                  ....*....|...
gi 2225819928  81 LIPIIVVVLTGVT 93
Cdd:PRK12507   93 IPALLIVLLFGVT 105
COG1563 COG1563
Uncharacterized MnhB-related membrane protein [General function prediction only];
2-70 8.67e-12

Uncharacterized MnhB-related membrane protein [General function prediction only];


Pssm-ID: 441171 [Multi-domain]  Cd Length: 81  Bit Score: 55.58  E-value: 8.67e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225819928  2 LLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGK 70
Cdd:COG1563    9 LLALLVISAIAAVLQKDLLAAVILFGIFSLLAALLFVLLGAPDVALTEAAVGAGLSTVLFLLALRKTGR 77
MbhD pfam13244
MBH, subunit D; Hydrogen gas-evolving membrane-bound hydrogenase (MBH) is a respiratory ...
 4-70 1.21e-07

MBH, subunit D; Hydrogen gas-evolving membrane-bound hydrogenase (MBH) is a respiratory complex homologous to the quinone-reducing Complex I. Like Complex I, MBH has peripheral and membrane arms. MBH is made of 14 subunits (MbhA-N). MbhJ, K, L, N and M form the Membrane-anchored hydrogenase module. MbhJ, K, L, N are predicted to be exposed to the cytoplasm and form the peripheral arm. The remaining 10 subunits are predicted to be integral membrane proteins forming the membrane arm, made of 44 transmembrane helices (TMH). MbhA, B, C and F form the Sodium translocation module. MbhD, E, G and H form the Proton translocation module. MbhI is the linker between the hydrogenase module and the proton-translocating membrane module. It anchors the discontinuous TMH7 of MbhH via its middle lateral helix and the C-terminal of TMH2, found in MbhE. MbhD and MbhE together are equivalent to Nqo10 of Complex I. MbhD has three TM helices.


Pssm-ID: 463816 [Multi-domain]  Cd Length: 67  Bit Score: 44.30  E-value: 1.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2225819928  4 AFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGK 70
Cdd:pfam13244  1 LLLVVAALAAVLARDRLAAVILLGVVGLGVALLFVLLGAPDVALTQAAVGEGLTTVLFLLALRRLPR 67
 
Name Accession Description Interval E-value
PRK12507 PRK12507
putative monovalent cation/H+ antiporter subunit B; Reviewed
 1-93 6.20e-18

putative monovalent cation/H+ antiporter subunit B; Reviewed


Pssm-ID: 237121 [Multi-domain]  Cd Length: 332  Bit Score: 75.85  E-value: 6.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225819928   1 MLLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGKRRREPRRRRt 80
Cdd:PRK12507   14 LILFLLILISIKIIFAKDLLNAVMLTSVFSLLIAVSFLIMDAPDVAMTEAAVGAGLSTCVYLNALKLTGRLKNIERTKI- 92

                          90
                  ....*....|...
gi 2225819928  81 LIPIIVVVLTGVT 93
Cdd:PRK12507   93 IPALLIVLLFGVT 105
PRK12504 PRK12504
DUF4040 domain-containing protein;
1-89 6.56e-15

DUF4040 domain-containing protein;


Pssm-ID: 183561 [Multi-domain]  Cd Length: 178  Bit Score: 65.75  E-value: 6.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225819928   1 MLLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGKRRREPRRRRT 80
Cdd:PRK12504    9 ALLLFLVATAVATALLRDVLASIVVFAAFSLGMALIYLILDAPDVAITEAAVGAGISTVLLLLTLALTGRPDVDKVFERI 88


                  ....*....
gi 2225819928  81 LIPIIVVVL 89
Cdd:PRK12504   89 NVPAVLIAL 97
COG1563 COG1563
Uncharacterized MnhB-related membrane protein [General function prediction only];
2-70 8.67e-12

Uncharacterized MnhB-related membrane protein [General function prediction only];


Pssm-ID: 441171 [Multi-domain]  Cd Length: 81  Bit Score: 55.58  E-value: 8.67e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225819928  2 LLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGK 70
Cdd:COG1563    9 LLALLVISAIAAVLQKDLLAAVILFGIFSLLAALLFVLLGAPDVALTEAAVGAGLSTVLFLLALRKTGR 77
MbhD pfam13244
MBH, subunit D; Hydrogen gas-evolving membrane-bound hydrogenase (MBH) is a respiratory ...
 4-70 1.21e-07

MBH, subunit D; Hydrogen gas-evolving membrane-bound hydrogenase (MBH) is a respiratory complex homologous to the quinone-reducing Complex I. Like Complex I, MBH has peripheral and membrane arms. MBH is made of 14 subunits (MbhA-N). MbhJ, K, L, N and M form the Membrane-anchored hydrogenase module. MbhJ, K, L, N are predicted to be exposed to the cytoplasm and form the peripheral arm. The remaining 10 subunits are predicted to be integral membrane proteins forming the membrane arm, made of 44 transmembrane helices (TMH). MbhA, B, C and F form the Sodium translocation module. MbhD, E, G and H form the Proton translocation module. MbhI is the linker between the hydrogenase module and the proton-translocating membrane module. It anchors the discontinuous TMH7 of MbhH via its middle lateral helix and the C-terminal of TMH2, found in MbhE. MbhD and MbhE together are equivalent to Nqo10 of Complex I. MbhD has three TM helices.


Pssm-ID: 463816 [Multi-domain]  Cd Length: 67  Bit Score: 44.30  E-value: 1.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2225819928  4 AFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLTGK 70
Cdd:pfam13244  1 LLLVVAALAAVLARDRLAAVILLGVVGLGVALLFVLLGAPDVALTQAAVGEGLTTVLFLLALRRLPR 67
PRK08378 PRK08378
hypothetical protein; Provisional
 1-68 6.96e-04

hypothetical protein; Provisional


Pssm-ID: 236253 [Multi-domain]  Cd Length: 93  Bit Score: 35.54  E-value: 6.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2225819928  1 MLLAFLVVIAFAVIHMRDLVAIIMLAGMYSLITAIIFVVMDAVDVAFTEAAVGAGISTVLMLATLSLT 68
Cdd:PRK08378  10 IILALMIISAILAVEWRDLLAAAVGMAAVSLFASLEFFMLQAPDVAMAEAAIGAALSTAVVIFAIKRT 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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