|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
98-449 |
3.62e-83 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 261.03 E-value: 3.62e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 98 LHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDYYEDMQAIRRLMIQVLIFVLLSGSVIILFISRYF 177
Cdd:COG5002 31 LLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLAL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 178 VRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQ---ALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAI 254
Cdd:COG5002 111 LILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERditELERLEQMRREFVANVSHELRTPLTSIRGYLELL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 255 KDGVV-SVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNL-- 331
Cdd:COG5002 191 LDGAAdDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpe 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 332 EPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSG 411
Cdd:COG5002 271 DPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGG 350
|
330 340 350
....*....|....*....|....*....|....*...
gi 2225873610 412 SGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG5002 351 TGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
214-449 |
6.71e-74 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 231.72 E-value: 6.71e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 214 QFNQMAQALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGV-VSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLD 292
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 293 QDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEP--LTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQ 370
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPelPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225873610 371 EESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
149-449 |
6.31e-66 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 214.39 E-value: 6.31e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 149 QAIRRLMIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKNVDEM 228
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 229 RKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVsvDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLDEQ 308
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 309 IRRIVLKTEPQWQEKHILVELNLEP--LTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGI 386
Cdd:COG0642 188 LEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGI 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2225873610 387 PDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG0642 268 PPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
154-449 |
2.52e-43 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 157.43 E-value: 2.52e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 154 LMIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKN--------- 224
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEqreeleerr 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 225 ----------------VDEMRKTFVSN----------------------------------------------------- 235
Cdd:COG5000 90 ryletilenlpagvivLDADGRITLANpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 236 --------------------------------------VSHEIQSPLTSIKGYTRAIKDGVVSVDQQD-----KYLGIIY 272
Cdd:COG5000 170 llvrasplrddgyvivfdditellraerlaawgelarrIAHEIKNPLTPIQLSAERLRRKLADKLEEDredleRALDTII 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 273 DEADRLSRLSEHLLKMTKLDQdaypINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEP--LTLALDEDLMEQVWLNL 350
Cdd:COG5000 250 RQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPdlPEVLADRDQLEQVLINL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 351 IVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYkvdSSRTgvdSGSGLGLSIVKRIVMLHEGRT 430
Cdd:COG5000 326 LKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTKP---KGTGLGLAIVKKIVEEHGGTI 399
|
410
....*....|....*....
gi 2225873610 431 DCISQEGVGTTFFVRLPKS 449
Cdd:COG5000 400 ELESRPGGGTTFTIRLPLA 418
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
52-449 |
2.04e-42 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 156.87 E-value: 2.04e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 52 AIIETVDPEEHEELLPIFEDLGLAVEVLSHEELVIFGLQHKYLEEPLHESEINTLTSRSARIIDYTDTELRRDIVTLVDV 131
Cdd:COG4251 105 ALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 132 EGEPMYARITLDYYEDMQAIRRLMIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQL 211
Cdd:COG4251 185 LLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEEL 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 212 MEQFNQMAQALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSV--DQQDKYLGIIYDEADRLSRLSEHLLKMT 289
Cdd:COG4251 265 EEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKldEEGREYLERIRDAAERMQALIDDLLAYS 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 290 KLDQDayPINKQPYRLDEQIRRIVLKTEPQWQEKHilVELNLEPL-TLALDEDLMEQVWLNLIVNAIRYNKPG--GSIYI 366
Cdd:COG4251 345 RVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERG--AEIEVGPLpTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEI 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 367 NHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRL 446
Cdd:COG4251 421 GAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498
|
...
gi 2225873610 447 PKS 449
Cdd:COG4251 499 PKA 501
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
148-447 |
2.90e-39 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 147.15 E-value: 2.90e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 148 MQAIRRLMIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTER-EDELGQLMEQFNQMAQALKNVD 226
Cdd:TIGR01386 159 LDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRaPAELRELAQSFNAMLGRLEDAF 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 227 EMRKTFVSNVSHEIQSPLTSIKGYTRAikdgVVSVDQ-QDKYLGIIY---DEADRLSRLSEHLLKMTKLDQDAYPINKQP 302
Cdd:TIGR01386 239 QRLSQFSADLAHELRTPLTNLLGQTQV----ALSQPRtGEEYREVLEsnlEELERLSRMVSDMLFLARADNGQLALERVR 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 303 YRLDEQIRRIVLKTEPQWQEKHILVELNLEpLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYInHYQEESNHV-FRIND 381
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGVRIRVEGE-GLVRGDPQMFRRAISNLLSNALRHTPDGGTITV-RIERRSDEVrVSVSN 392
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 382 TGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGvGTTFFVRLP 447
Cdd:TIGR01386 393 PGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG-KTRFILRFP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
83-449 |
9.30e-39 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 143.79 E-value: 9.30e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 83 ELVIFGLQHKYLEEPLHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDYYEDMQAIRRLMIQVLIFV 162
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 163 LLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQfnqMAQA--LKNVDEMrktfVSNVSHEI 240
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQ---LVQSekLAALGEL----AAGIAHEI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 241 QSPLTSIKGYTRAIKDGV---VSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAypinKQPYRLDEQIRRIVLKTE 317
Cdd:COG4191 154 NNPLAAILGNAELLRRRLedePDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 318 PQWQEKHILVELNLEP--LTLALDEDLMEQVWLNLIVNAIR--YNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPF 393
Cdd:COG4191 230 PRLKARGIEVELDLPPdlPPVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLER 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2225873610 394 VFDRFY--KvdssrtGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG4191 310 IFEPFFttK------PVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
147-429 |
2.11e-37 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 142.08 E-value: 2.11e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 147 DMQAIRRLMIQVLIFVLLSgSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKNVD 226
Cdd:PRK10549 159 DKQQRRTSWLIVALSTLLA-ALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 227 EMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDkyLGIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLD 306
Cdd:PRK10549 238 QMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPES--VASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLV 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 307 EQIRRIVLKTEPQWQEKHILVELNL-EPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIG 385
Cdd:PRK10549 316 PLLEVAGGAFRERFASRGLTLQLSLpDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPG 395
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2225873610 386 IPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGR 429
Cdd:PRK10549 396 VSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGR 439
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
212-447 |
3.03e-37 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 139.60 E-value: 3.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 212 MEQFNQMAQALKNVDEMrktfVSNVSHEIQSPLTSIKGYTRAIKDGVvSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKL 291
Cdd:COG3852 122 LERELRRAEKLAAVGEL----AAGLAHEIRNPLTGIRGAAQLLEREL-PDDELREYTQLIIEEADRLNNLVDRLLSFSRP 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 292 DqdayPINKQPYRLDEQIRRIV--LKTEPQwqeKHILVELNLEP--LTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYIN 367
Cdd:COG3852 197 R----PPEREPVNLHEVLERVLelLRAEAP---KNIRIVRDYDPslPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIR 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 368 HYQEESNH----------VFRINDTGIGIPDEEIPFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEG 437
Cdd:COG3852 270 TRVERQVTlgglrprlyvRIEVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPG 343
|
250
....*....|
gi 2225873610 438 VGTTFFVRLP 447
Cdd:COG3852 344 KGTTFRIYLP 353
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
149-429 |
4.53e-37 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 141.14 E-value: 4.53e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 149 QAIRRLMIQVLIFVLLSGSVIILFIsryfVRSIQQITRAAEQLTHGDfEVNLKTEREDELGQLmeqfnqmAQALknvDEM 228
Cdd:PRK11100 182 RRILWAGALLLGIALLIGAGVVWWL----NRSIRRLTRYADAVTEGK-PVPLPKLGSSELREL-------AQAL---ESM 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 229 RK---------TFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQdKYLGIIYDEADRLSRLSEHLLKMTKLDQDAYPIN 299
Cdd:PRK11100 247 RVklegkayveQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRA-RFTGNILTQSARLQQLIDRLLELARLEQRQELEV 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 300 KQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRI 379
Cdd:PRK11100 326 LEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSV 405
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2225873610 380 NDTGIGIPDEEIPFVFDRFY---KVDSSRtgvdSGSGLGLSIVKRIVMLHEGR 429
Cdd:PRK11100 406 EDQGPGIPDYALPRIFERFYslpRPANGR----KSTGLGLAFVREVARLHGGE 454
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
232-447 |
2.40e-36 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 141.26 E-value: 2.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 232 FVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQdKYLGIIYDEADRLSRLSEHLLKMTKLDQdaypINKQPYRLDEQIRR 311
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQ-EYLSVVLREVDRLNKVIDQLLEFSRPRE----SQWQPVSLNALVEE 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 312 IVLKTEPQWQEKHILVELNLEP-LTLA-LDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVF-RINDTGIGIPD 388
Cdd:PRK11360 468 VLQLFQTAGVQARVDFETELDNeLPPIwADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAvSIEDNGCGIDP 547
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2225873610 389 EEIPFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK11360 548 ELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
234-447 |
3.18e-36 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 136.84 E-value: 3.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 234 SNVSHEIQSPLTSIKGYTRAIKDGVvSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQdaypINKQPYRLDEQIRRIV 313
Cdd:COG5807 152 AGIAHEIRNPLTSIKGFLQLLQESR-EDSEREEYFNIIISEIDRINTIITELLVLSKPKK----FNFKKLNLNDVLEDVI 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 314 LKTEPQWQEKHILVELNLEPLTLAL--DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEI 391
Cdd:COG5807 227 ALLSTEAILKNISIKYDLADDEPVIngDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVL 306
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 392 PFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:COG5807 307 EKIGEPFF------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
227-447 |
1.06e-34 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 134.49 E-value: 1.06e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 227 EMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQdKYLGIIYDEADRLSRLSEHLLKMTKLDQdaypINKQPYRLD 306
Cdd:COG5808 239 ELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQ-KYFDIIQEEIQRINQIVSEFLVLGKPTA----KKLELDDLN 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 307 EQIRRIVLKTEPQWQEKHILVELNL--EPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGI 384
Cdd:COG5808 314 ELIEEILSIIDSEANLKNIRVEKQSldEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDNGE 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2225873610 385 GIPDEEIPFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:COG5808 394 GIPEDIIDEIFEPFV------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
339-449 |
3.68e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 120.83 E-value: 3.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVdSGSGLGLSI 418
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI-GGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 2225873610 419 VKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
343-446 |
3.15e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 118.09 E-value: 3.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRI 422
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 2225873610 423 VMLHEGRTDCISQEGVGTTFFVRL 446
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
217-448 |
4.40e-32 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 126.66 E-value: 4.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 217 QMAQaLKNvdeMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDqdAY 296
Cdd:PRK11006 196 QMHQ-LEG---ARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIE--AA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 297 PINKQPYRLDEQIRRIVLKTEPQW--QEKH-ILVELNlEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEES 373
Cdd:PRK11006 270 PTIDLNEKVDVPMMLRVLEREAQTlsQGKHtITFEVD-NSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQ 348
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2225873610 374 NHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPK 448
Cdd:PRK11006 349 GAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
67-449 |
1.08e-31 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 126.63 E-value: 1.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 67 PIFEDLGLAVEVLSHEELVifgLQHKYLEEPLHESEintltSRSARIIDYTDtelrrDIVTLVDVEGE-----PMYARIT 141
Cdd:COG5809 108 PIFDQNGDIEGMLAISRDI---TERKRMEEALRESE-----EKFRLIFNHSP-----DGIIVTDLDGRiiyanPAACKLL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 142 ldYYEDMQairrlmiqvlifvlLSGSVIILFISRYFVRSIQQ-ITRAAEQLTHGDFEVNLKTE---------------RE 205
Cdd:COG5809 175 --GISIEE--------------LIGKSILELIHSDDQENVAAfISQLLKDGGIAQGEVRFWTKdgrwrlleasgapikKN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 206 DELGQLMEQFNQMAQALKNVDEMRKT--------FVSNVSHEIQSPLTSIKGYTRAIKDGVVsvDQQDKYLGIIYDEADR 277
Cdd:COG5809 239 GEVDGIVIIFRDITERKKLEELLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTID--EEQKTYLDIMLSELDR 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 278 L-SRLSEhLLKMTKLDQDAYpinkQPYRLDEQIRRIVLKTEPQWQEKHILVELNLE---PLtLALDEDLMEQVWLNLIVN 353
Cdd:COG5809 317 IeSIISE-FLVLAKPQAIKY----EPKDLNTLIEEVIPLLQPQALLKNVQIELELEddiPD-ILGDENQLKQVFINLLKN 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 354 AIRYNKPGGSIYINHYQEESNHV-FRINDTGIGIPDEEIPFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDC 432
Cdd:COG5809 391 AIEAMPEGGNITIETKAEDDDKVvISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITV 464
|
410
....*....|....*..
gi 2225873610 433 ISQEGVGTTFFVRLPKS 449
Cdd:COG5809 465 ESEVGKGTTFSITLPIK 481
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
142-448 |
1.36e-31 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 126.04 E-value: 1.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 142 LDYYEDMQAiRRLMIQVLIfvllsgSVIILFISRYFVRS----IQQITRAAEQLTHGDFEVNLKTERED-ELGQLMEQFN 216
Cdd:PRK09835 177 LHYINDLKN-KLIMTASVI------SLLIVFIVLLAVHKghapIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFN 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 217 QMAQALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAikdgVVSVDQQDKYL-GIIY---DEADRLSRLSEHLLKMTKLD 292
Cdd:PRK09835 250 HMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEI----ALSQSRSQKELeDVLYsnlEELTRMAKMVSDMLFLAQAD 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 293 QDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEE 372
Cdd:PRK09835 326 NNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVD 405
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 373 SNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGRTdCISQEGVGTTFFVRLPK 448
Cdd:PRK09835 406 HQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTV-AVTSDARGTRFVISLPR 480
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
151-447 |
6.09e-29 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 117.78 E-value: 6.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 151 IRRLMIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKNVDEMRK 230
Cdd:PRK10604 134 MRLLDIALLALIGLSLAFPVFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 231 TFVSNVSHEIQSPLTSIKgYTRAIKDGVVSVDQQdkylgIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLDEQIR 310
Cdd:PRK10604 214 QLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQ-----ALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLS 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 311 RIVlkTEPQW--QEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNkpGGSIYINHYQEESNHVFRINDTGIGIPD 388
Cdd:PRK10604 288 THL--ADIQAvtPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPP 363
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2225873610 389 EEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK10604 364 EERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
236-449 |
7.63e-29 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 118.30 E-value: 7.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 236 VSHEIQSPLTSIKGYTRAIKDGVvsvDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDaypiNKQPYRLDEQIRRIV-- 313
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQLLQPGI---EDKEEYFDIMLSELDRIESIISEFLALAKPQAV----NKEKENINELIQDVVtl 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 314 LKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPF 393
Cdd:COG5805 367 LETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKK 446
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 394 VFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG5805 447 LGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
339-447 |
2.48e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.84 E-value: 2.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYInHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdsGSGLGLSI 418
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITV-TLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG---GTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 2225873610 419 VKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
154-428 |
9.07e-28 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 114.62 E-value: 9.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 154 LMIQVLIFVLLSGSVIILFIsRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKNVDEMRKTFV 233
Cdd:PRK09467 155 LFRYTLAIGLLSVAGGWLFI-RIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLM 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 234 SNVSHEIQSPLTSIKGYTRAIKdgvvsvdQQDKYL--GIIYDEADrLSRLSEHLLKMTKLDQdaypinkQPYRLDEQIRR 311
Cdd:PRK09467 234 AGVSHDLRTPLTRIRLATEMMS-------EEDGYLaeSINKDIEE-CNAIIEQFIDYLRTGQ-------EMPMEMADLNA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 312 I---VLKTEPQWqEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKpgGSIYINHYQEESNHVFRINDTGIGIPD 388
Cdd:PRK09467 299 LlgeVIAAESGY-EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEGKRAWFQVEDDGPGIPP 375
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2225873610 389 EEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRIVMLHEG 428
Cdd:PRK09467 376 EQLKHLFQPFTRGDSARGS--SGTGLGLAIVKRIVDQHNG 413
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
343-447 |
1.26e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 100.26 E-value: 1.26e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPGG-SIYINHYQEESNHV---FRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSI 418
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 2225873610 419 VKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
154-447 |
2.18e-25 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 107.95 E-value: 2.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 154 LMIQVLIFVLLSGSVIILFISRYFVRSIQQITRaaeqlthgdfEVNLKtEREDELGQLmeqfnqmaqalknvdemrktfV 233
Cdd:PRK10364 194 LIILFALATVLLASLLAFFWYRRYLRSRQLLQD----------EMKRK-EKLVALGHL---------------------A 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 234 SNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQdaypINKQPYRLDEQIRRIV 313
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH----LALQAVDLNDLINHSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 314 LKTEPQWQEKHILVELNLEPL--TLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEI 391
Cdd:PRK10364 318 QLVSQDANSREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQL 397
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 392 PFVFDRFYkvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK10364 398 EAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
2.56e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 99.58 E-value: 2.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 349 NLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEG 428
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|.
gi 2225873610 429 RTDCISQEGVGTTFFVRLPKS 449
Cdd:cd16952 87 RLLIASELGKGSRFTCLFPSS 107
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
206-439 |
3.69e-24 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 104.35 E-value: 3.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 206 DELGQLMEQFNQMAqalknVDEMRktFVSNVSHEIQSPLTSIKGYTRAIKdgvVSVDQ---QDKYLGIIYDEADRLSRLS 282
Cdd:PRK10337 221 EALNQLFARTHAMM-----VRERR--FTSDAAHELRSPLAALKVQTEVAQ---LSDDDpqaRKKALLQLHAGIDRATRLV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 283 EHLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLE---------PLTLALdedLMEqvwlNLIVN 353
Cdd:PRK10337 291 DQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNahpvirtgqPLLLSL---LVR----NLLDN 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 354 AIRYNKPGGSIYINHyqeeSNHVFRINDTGIGIPDEEIPFVFDRFYKvdssRTGVD-SGSGLGLSIVKRIVMLHEGRTDC 432
Cdd:PRK10337 364 AIRYSPQGSVVDVTL----NARNFTVRDNGPGVTPEALARIGERFYR----PPGQEaTGSGLGLSIVRRIAKLHGMNVSF 435
|
....*..
gi 2225873610 433 ISQEGVG 439
Cdd:PRK10337 436 GNAPEGG 442
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-429 |
6.99e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 92.91 E-value: 6.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSI 418
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90
....*....|.
gi 2225873610 419 VKRIVMLHEGR 429
Cdd:cd16946 81 CHNIALAHGGT 91
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
205-447 |
5.56e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 94.25 E-value: 5.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 205 EDELGQLMEQFNQMAQALKNVDEMrktfVSNVSHEIQSPLT--SIKGYTRAIKDGVVSVDQQDKYLGIIYDEADR----L 278
Cdd:PRK09303 131 SDELFVLRQENETLLEQLKFKDRV----LAMLAHDLRTPLTaaSLALETLELGQIDEDTELKPALIEQLQDQARRqleeI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 279 SRLSEHLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLePLTLAL---DEDLMEQVWLNLIVNAI 355
Cdd:PRK09303 207 ERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDI-PSDLPSvyaDQERIRQVLLNLLDNAI 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 356 RYNKPGGSIYINHYQEESNHV-FRINDTGIGIPDEEIPFVF-DRFYKVDSSRTgvdSGSGLGLSIVKRIVMLHEGRTDCI 433
Cdd:PRK09303 286 KYTPEGGTITLSMLHRTTQKVqVSICDTGPGIPEEEQERIFeDRVRLPRDEGT---EGYGIGLSVCRRIVRVHYGQIWVD 362
|
250
....*....|....
gi 2225873610 434 SQEGVGTTFFVRLP 447
Cdd:PRK09303 363 SEPGQGSCFHFTLP 376
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
157-428 |
6.58e-21 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 94.61 E-value: 6.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 157 QVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTER-EDELGQLMEQFNQMAQALKNVDEMRKTFVSN 235
Cdd:PRK09470 170 LLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETgPQEFRQAGASFNQMVTALERMMTSQQRLLSD 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 236 VSHEIQSPLTSIKGYTRAI--KDGvvsvdqQDKYLGIIYDEADRLSRLSEHLLKMTK------LDQDAYPINKqpyrlde 307
Cdd:PRK09470 250 ISHELRTPLTRLQLATALLrrRQG------ESKELERIETEAQRLDSMINDLLVLSRnqqknhLERETFKANS------- 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 308 qIRRIVL---KTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKpgGSIYINHYQEESNHVFRINDTGI 384
Cdd:PRK09470 317 -LWSEVLedaKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVDDDGP 393
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2225873610 385 GIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEG 428
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRG 437
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
217-447 |
1.44e-20 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 94.62 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 217 QMAQALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSvDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAY 296
Cdd:PRK11091 271 RYQDALEKASRDKTTFISTISHELRTPLNGIVGLSRILLDTELT-AEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKL 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 297 PINKQPYRLDEQIRRIVLKTEPQWQEKHIlvELNLEPLT-----LALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQE 371
Cdd:PRK11091 350 QLDNQPIDFTDFLADLENLSGLQAEQKGL--RFDLEPLLplphkVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEE 427
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2225873610 372 ESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDS-GSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK11091 428 GDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-429 |
3.96e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 85.54 E-value: 3.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 330 NLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINhYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvd 409
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNYG-- 77
|
90 100
....*....|....*....|
gi 2225873610 410 sGSGLGLSIVKRIVMLHEGR 429
Cdd:cd16940 78 -GSGLGLSIVKRIVELHGGQ 96
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
148-447 |
4.84e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 93.17 E-value: 4.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 148 MQAIRRLMIQVLIFVLLSgSVIILFISRYFVRSIQQ----ITRAAEQlthgDFEVNLKTEREDELGQLMEQFNQMAQALK 223
Cdd:PRK15347 293 KPALQQLPFALLILVLLT-SVLFLLLRRYLAKPLWRfvdiINKTGPA----ALEPRLPENRLDELGSIAKAYNQLLDTLN 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 224 --------NVDE----------------MRKT-FVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQD----------KYL 268
Cdd:PRK15347 368 eqydtlenKVAErtqalaeakqraeqanKRKSeHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDladtarqctlSLL 447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 269 GIIYD-------EADRLSRLSEH--LLKMtkLDQDAYPINKQPyrldeQIRRIVLKTepqwqekhiLVELNLePLTLALD 339
Cdd:PRK15347 448 AIINNlldfsriESGQMTLSLEEtaLLPL--LDQAMLTIQGPA-----QSKSLTLRT---------FVGAHV-PLYLHLD 510
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 340 EDLMEQVWLNLIVNAIRYNkPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRtgvdSGSGLGLSIV 419
Cdd:PRK15347 511 SLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS----QGTGLGLTIA 585
|
330 340
....*....|....*....|....*...
gi 2225873610 420 KRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK15347 586 SSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
7.16e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 84.36 E-value: 7.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVdsGSGLGLSIVKRI 422
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE--GAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 2225873610 423 VMLHEGRTDcISQEGVGTTFFVRLP 447
Cdd:cd16923 79 IELHGGSAS-AEYDDNHDLFKVRLP 102
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
236-449 |
3.14e-19 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 89.16 E-value: 3.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 236 VSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKldqdAYPINKQPYRLDEQIRRIVLK 315
Cdd:COG5806 208 IAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAK----PQPEKLEKIDVSEELEHVIDV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 316 TEPQWQEKHILVELNLEP-LTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFV 394
Cdd:COG5806 284 LSPYANMNNVEIQTELEPgLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERL 363
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2225873610 395 FDRFYkvdSSRTgvdSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG5806 364 GEPYF---STKE---KGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
6.11e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 81.73 E-value: 6.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNkpGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVKRI 422
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 2225873610 423 VMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-447 |
1.61e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 80.54 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 342 LMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYkvdsSRTGVDSGSGLGLSIVKR 421
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF----TTKPVGEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 2225873610 422 IVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
149-447 |
7.46e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 7.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 149 QAIRRLMIQVLIFVLLSGSVIILFISRYFVRSIQQI----TRAAEQLTHGDFEVNLKTE---RE-DELGQLMEQFNQMAQ 220
Cdd:PRK11466 324 KASARGQYSLLLLGMVSLCALILILWRVVYRSVTRPlaeqTQALQRLLDGDIDSPFPETagvRElDTIGRLMDAFRSNVH 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 221 AL--------------------------------KNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDkYL 268
Cdd:PRK11466 404 ALnrhreqlaaqvkartaelqelviehrqaraeaEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRD-DL 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 269 GIIYDEADRLSRLSEHLLKMTKLDQDAY--PINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLE---PLTLALDEDLM 343
Cdd:PRK11466 483 RAITDSGESLLTILNDILDYSAIEAGGKnvSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIAddlPTALMGDPRRI 562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 344 EQVWLNLIVNAIRYNKPgGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVdSSRTGvdsGSGLGLSIVKRIV 423
Cdd:PRK11466 563 RQVITNLLSNALRFTDE-GSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV-SGKRG---GTGLGLTISSRLA 637
|
330 340
....*....|....*....|....
gi 2225873610 424 MLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK11466 638 QAMGGELSATSTPEVGSCFCLRLP 661
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
1.03e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 78.14 E-value: 1.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPGGSIYIN-HYQEESN-HVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvdSGSGLGLSIVK 420
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEvGAEDVGEeWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEY--EGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 2225873610 421 RIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
279-447 |
2.00e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 85.09 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 279 SRLSEHLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYN 358
Cdd:PRK10490 715 TRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYA 794
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 359 KPGGSIYIN-HYQEESNHVfRINDTGIGIPDEEIPFVFDRFYKVD--SSRTGVdsgsGLGLSIVKRIVMLHEGRTDCISQ 435
Cdd:PRK10490 795 GAQAEIGIDaHVEGERLQL-DVWDNGPGIPPGQEQLIFDKFARGNkeSAIPGV----GLGLAICRAIVEVHGGTIWAENR 869
|
170
....*....|..
gi 2225873610 436 EGVGTTFFVRLP 447
Cdd:PRK10490 870 PEGGACFRVTLP 881
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-448 |
2.33e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 77.37 E-value: 2.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 349 NLIVNAIRYNKpgGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEG 428
Cdd:cd16949 7 NVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGG 84
|
90 100
....*....|....*....|
gi 2225873610 429 RTDCISQEGVGTTFFVRLPK 448
Cdd:cd16949 85 KIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
212-447 |
8.59e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 83.10 E-value: 8.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 212 MEQFNQ-MAQALKNVDEMRKTFVSNVSHEIQSPLTSIKG-----YTRAIKDGVVSV-----DQQDKYLGIIYDeadrlsr 280
Cdd:PRK10841 429 MEESLQeMAQAAEQASQSKSMFLATVSHELRTPLYGIIGnldllQTKELPKGVDRLvtamnNSSSLLLKIISD------- 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 281 lsehLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEP-LTLALDEDLM--EQVWLNLIVNAIRY 357
Cdd:PRK10841 502 ----ILDFSKIESEQLKIEPREFSPREVINHITANYLPLVVKKRLGLYCFIEPdVPVALNGDPMrlQQVISNLLSNAIKF 577
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 358 NKPGGsIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDssrTGVDS---GSGLGLSIVKRIVMLHEGRTDCIS 434
Cdd:PRK10841 578 TDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVG---TGVQRnfqGTGLGLAICEKLINMMDGDISVDS 653
|
250
....*....|...
gi 2225873610 435 QEGVGTTFFVRLP 447
Cdd:PRK10841 654 EPGMGSQFTIRIP 666
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
339-447 |
9.64e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 75.61 E-value: 9.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHV-FRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLS 417
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFlLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 2225873610 418 IVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
179-449 |
2.15e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 81.65 E-value: 2.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 179 RSIQQITRAAEQLTHGDFEVNLKTEReDELGQLMEQfnqmAQALKNVDemrkTFVSNVSHEIQSPLTSIKGYTRAIKDGV 258
Cdd:PRK13837 409 GELQLLELALDCLAHAIERRRLETER-DALERRLEH----ARRLEAVG----TLASGIAHNFNNILGAILGYAEMALNKL 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 259 VSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKlDQDAypiNKQPYRLDEQIRRIVlktePQwqekhILVELNlEPLTLAL 338
Cdd:PRK13837 480 ARHSRAARYIDEIISAGARARLIIDQILAFGR-KGER---NTKPFDLSELVTEIA----PL-----LRVSLP-PGVELDF 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLM-----------EQVWLNLIVNAIRYNKPGGSIYINHYQ------EESNH---------VFRINDTGIGIPDEEIP 392
Cdd:PRK13837 546 DQDQEpavvegnpaelQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapKVLSHgvlppgryvLLRVSDTGAGIDEAVLP 625
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2225873610 393 FVFDRFYkvdSSRTGvdsGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:PRK13837 626 HIFEPFF---TTRAG---GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPS 676
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
1-448 |
6.46e-16 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 79.68 E-value: 6.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 1 MMKRSLYWKFVFIFIIGVGLSVIISYAITTHFFQNQTAFKAELNSATQGVTAIIETVDPEEHEELLPIFEDLGLAVEVLS 80
Cdd:COG2972 4 SLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 81 HEELVIFGLQHKYLEEPLHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDY-YEDMQAIRRLMIQVL 159
Cdd:COG2972 84 LLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSElFRGLFSLRRLILLII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 160 IFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFeVNLKTEREDELGQLMEQFNQMAQALKN-VDEMRKTFVSNVSH 238
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKElIEEVYELELEKKEA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 239 EIQS------P------LTSIKGYtraikdgvvsvdqqdkylgIIYDEADRLSRLSEHLLKMTKldqdaypinkqpYRLD 306
Cdd:COG2972 243 ELKAlqaqinPhflfntLNSIRWL-------------------AELEDPEEAEEMLEALSKLLR------------YSLS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 307 EQIRRIVLKTEPQWQEKHILVEL-----NLEpLTLALDEDLMEQVWLNLIV-----NAIRY----NKPGGSIYINHYQEE 372
Cdd:COG2972 292 KGDELVTLEEELELIKSYLEIQKlrfgdRLE-VEIEIDEELLDLLIPKLILqplveNAIEHgiepKEGGGTIRISIRKEG 370
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225873610 373 SNHVFRINDTGIGIPDEEIPFVFDRFykvdssrTGVDSGSGLGLSIVKRIVMLHEGRTDCI---SQEGVGTTFFVRLPK 448
Cdd:COG2972 371 DRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGEEYGLeieSEPGEGTTVTIRIPL 442
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-446 |
1.50e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.93 E-value: 1.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 327 VELNLE--PLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSS 404
Cdd:cd16947 3 VEINIPdrPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDS 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2225873610 405 RTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRL 446
Cdd:cd16947 83 RNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-442 |
2.39e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 71.55 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 350 LIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSgSGLGLSIVKRIV--MLHE 427
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQES-TGMGLYLVKKLCdkLGHK 91
|
90
....*....|....*
gi 2225873610 428 grTDCISQEGVGTTF 442
Cdd:cd16948 92 --IDVESEVGEGTTF 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
149-429 |
4.80e-15 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 76.16 E-value: 4.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 149 QAIRRLMIQVLIFVLLSgsviiLFISRYFVRSI---------QQITRAAEQLT----HGDFEvnlkteredELGQLMEQF 215
Cdd:PRK10755 58 EAVASLLVPSLVMVSLT-----LLICFQAVRWItrplaelqkELEARTADNLTpiaiHSSTL---------EIEAVTSAL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 216 NQMAQALKNVDEMRKTFVSNVSHEIQSPLTSIKGYTRAI-KDGVVSVDQQDKYLgiiydeaDRLSRLSEHLLKMTKLDQD 294
Cdd:PRK10755 124 NQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLeKQHHIDVAPLIARL-------DQMMHTVEQLLQLARAGQS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 295 AYPINKQPYRLDEQI---RRIVLKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQE 371
Cdd:PRK10755 197 FSSGHYQTVKLLEDVilpSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQE 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2225873610 372 ESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSsRTGvdsGSGLGLSIVKRIVMLHEGR 429
Cdd:PRK10755 277 DGGAVLAVEDEGPGIDESKCGELSKAFVRMDS-RYG---GIGLGLSIVSRITQLHHGQ 330
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
1.34e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 69.35 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIR----YNKPGGSIYINHYQEESNHV-FRINDTGIGIPDEEIPFVFDRFYKVDSSrtgvdsGSGLGLS 417
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 2225873610 418 IVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
1.46e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 69.38 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPggSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRI 422
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 2225873610 423 VMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
224-447 |
2.91e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 75.16 E-value: 2.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 224 NVDEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPY 303
Cdd:PRK09959 707 NATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWV 786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 304 RLDEQIRRIVLKTEPQWQEKHILVELNL---EPLTLALDEDLMEQVWLNLIVNAIRYNKPGG-SIYINHYQEESNHV--- 376
Cdd:PRK09959 787 DIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNHAvik 866
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2225873610 377 FRINDTGIGIPDEEIPFVFDRFYKVDSSRTgvDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK09959 867 MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ--QTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
148-429 |
3.12e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 74.72 E-value: 3.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 148 MQAIRRLMIQVLIFVLL-SGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQL-------MEQFNQMA 219
Cdd:COG4192 321 VQQSGILLLAIALLSLLlAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIarllrvfRDQAIEKT 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 220 QALKNVDEMRK------------------------TFVSnVSHEIQSPLTSIKGYTRAIKDGVV--SVDQQDKYLGIIYD 273
Cdd:COG4192 401 QELETEIEERKrieknlrqtqdeliqaakmavvgqTMTS-LAHELNQPLNAMSMYLFSAKKALEqeNYAQLPTSLDKIEG 479
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 274 EADRLSRLSEHLLKMTKLDQDAYpinkQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEPLTLAlDEDLMEQVWLNLIVN 353
Cdd:COG4192 480 LIERMDKIIKSLRQFSRKSDTPL----QPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQG-DQVLLEQVLVNLLVN 554
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2225873610 354 AIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEE---IPFVfdrfykvdssrTGVDSGSGLGLSIVKRIVMLHEGR 429
Cdd:COG4192 555 ALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDklfTPFT-----------TTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
206-447 |
6.17e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 72.81 E-value: 6.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 206 DELGQLMEQFNQMAQALKnvdemRKTFVSNVSHEIQSPLTSIKG----YTRAIKDGVVSvdqqdKYLGIIYDEADRLSRL 281
Cdd:PRK11073 112 DNQRRLSQEQLQHAQQVA-----ARDLVRGLAHEIKNPLGGLRGaaqlLSKALPDPALT-----EYTKVIIEQADRLRNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 282 SEHLLKMTKldqdayPINKQPYRLD---EQIRRIVLKTEPQwqekHILVELNLEPL--TLALDEDLMEQVWLNLIVNAIR 356
Cdd:PRK11073 182 VDRLLGPQR------PGTHVTESIHkvaERVVQLVSLELPD----NVRLIRDYDPSlpELAHDPDQIEQVLLNIVRNALQ 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 357 -YNKPGGSIYI--------NHYQEESNHVFRIN--DTGIGIPDEeipfVFDR-FYKVDSSRTGvdsGSGLGLSIVKRIVM 424
Cdd:PRK11073 252 aLGPEGGTITLrtrtafqlTLHGERYRLAARIDieDNGPGIPPH----LQDTlFYPMVSGREG---GTGLGLSIARNLID 324
|
250 260
....*....|....*....|...
gi 2225873610 425 LHEGRTDCISQEGvGTTFFVRLP 447
Cdd:PRK11073 325 QHSGKIEFTSWPG-HTEFSVYLP 346
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
226-290 |
8.47e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 66.08 E-value: 8.47e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2225873610 226 DEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTK 290
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-428 |
1.91e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 66.33 E-value: 1.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGvDSGSGLGLSI 418
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRS-GGHYGMGLYI 79
|
90
....*....|
gi 2225873610 419 VKRIVMLHEG 428
Cdd:cd16975 80 AKNLVEKHGG 89
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-429 |
2.59e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 65.94 E-value: 2.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSgSGLGLSI 418
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAF 79
|
90
....*....|.
gi 2225873610 419 VKRIVMLHEGR 429
Cdd:cd16945 80 VQEVAQLHGGR 90
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
343-447 |
2.64e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 66.25 E-value: 2.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKPGGSI------------YINHYQE--ESNHV-FRINDTGIGIPDEEIPFVFDRFYkvdsSRTG 407
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLtietsnqrvdadYALNYRDliPGNYVcLEVSDTGSGMPAEVLRRAFEPFF----TTKE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2225873610 408 VDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
232-447 |
7.78e-13 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 70.65 E-value: 7.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 232 FVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDkY-----------LGIIYDeadrlsrlsehLLKMTKLDQDAYPINK 300
Cdd:PRK11107 296 FLANMSHELRTPLNGVIGFTRQTLKTPLTPTQRD-YlqtiersannlLAIIND-----------ILDFSKLEAGKLVLEN 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 301 QPYRLDEQIRRIVLKTEPQWQEKhilvelNLEpLTLALDEDL----------MEQVWLNLIVNAIRYNkPGGSIYIN-HY 369
Cdd:PRK11107 364 IPFSLRETLDEVVTLLAHSAHEK------GLE-LTLNIDPDVpdnvigdplrLQQIITNLVGNAIKFT-ESGNIDILvEL 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 370 QEESNH----VFRINDTGIGIPDEEIPFVFDRFYKVDSS---RTGvdsGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTF 442
Cdd:PRK11107 436 RALSNTkvqlEVQIRDTGIGISERQQSQLFQAFRQADASisrRHG---GTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
....*
gi 2225873610 443 FVRLP 447
Cdd:PRK11107 513 WFHLP 517
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-447 |
7.81e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 64.73 E-value: 7.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIRYNKP-GGSIYI----NHYQEESNHVFR------INDTGIGIPDEEIPFVFDRFYkvdSSRTGvdsG 411
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILrtrtQRQVTLGHPRHRlalrvsVIDNGPGIPPDLQDTIFYPMV---SGREN---G 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 2225873610 412 SGLGLSIVKRIVMLHEGRTDCISQEGvGTTFFVRLP 447
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
178-222 |
1.14e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 62.08 E-value: 1.14e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2225873610 178 VRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQAL 222
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
322-449 |
1.59e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 68.72 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 322 EKHILVELNLEPL--TLALDEDLMEQVWLNLIVNAIRY----NKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVF 395
Cdd:COG3290 259 ERGIDLTIDIDSDlpDLPLSDTDLVTILGNLLDNAIEAveklPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIF 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2225873610 396 DRFYkvdSSRTGvdSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLPKS 449
Cdd:COG3290 339 ERGF---STKLG--EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-447 |
2.35e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 63.36 E-value: 2.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 345 QVWLNLIVNAIRYNKPG-GSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIV 423
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 2225873610 424 MLHEGRT--DCISQEGV--GTTFFVRLP 447
Cdd:cd16953 83 EAHGGISvaENHNQPGQviGARFTVQLP 110
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
228-293 |
3.94e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.07 E-value: 3.94e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 228 MRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSvDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQ 293
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLD-EEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-446 |
4.81e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 62.09 E-value: 4.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 343 MEQVWLNLIVNAIR--YNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYkvdsSRTGVDSGSGLGLSIVK 420
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF----TTKPVGKGTGLGLSISY 76
|
90 100
....*....|....*....|....*.
gi 2225873610 421 RIVMLHEGRTDCISQEGVGTTFFVRL 446
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HAMP |
pfam00672 |
HAMP domain; |
172-224 |
4.96e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 60.33 E-value: 4.96e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2225873610 172 FISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKN 224
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
217-447 |
1.38e-11 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 66.88 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 217 QMAQAL--KNVdEMRKTFVSNVSHEIQSPLTSIKGYTRAIKDgVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQD 294
Cdd:PRK10618 437 QQAQREyeKNQ-QARKAFLQNIGDELKQPLQSLAQLAAQLRQ-TSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 295 AYPINKQPYRLDEQIRRIVLKTEPQWQEK--HILVELNLEP-LTLALDEDLMEQVWLNLIVNAI---RYNKPggSIYINH 368
Cdd:PRK10618 515 DWKPEQELFSLQDLIDEVLPEVLPAIKRKglQLLIHNHLKAeQLRIGDRDALRKILLLLLNYAItttAYGKI--TLEVDQ 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 369 YQEESNH-VFRINDTGIGIPDEEI-----PF----VFDRFYKvdssrtgvdsGSGLGLSIVKRIVMLHEGRTDCISQEGV 438
Cdd:PRK10618 593 DESSPDRlTIRILDTGAGVSIKELdnlhfPFlnqtQGDRYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGL 662
|
....*....
gi 2225873610 439 GTTFFVRLP 447
Cdd:PRK10618 663 GTRYSIHLK 671
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
228-293 |
1.48e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.50 E-value: 1.48e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2225873610 228 MRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSvDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQ 293
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-447 |
1.68e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 60.76 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 349 NLIVNAI----RYNKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRFYkvdSSRTGvdSGSGLGLSIVKRIVM 424
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV---STKGQ--GERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 2225873610 425 LHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
18-242 |
2.93e-11 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 65.43 E-value: 2.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 18 VGLSVIISYAITTHFFQNQTAFKAELNSATQGVTAIIETVDPEEHEELLPIFEDLGLAVEVLSHEELVIFGLQHKYLEEP 97
Cdd:COG0840 47 LLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 98 LHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDYYEDMQAIRRLMIQVLIFVLLSGSVIILFISRYF 177
Cdd:COG0840 127 LAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSI 206
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2225873610 178 VRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKN-VDEMRKTF--VSNVSHEIQS 242
Cdd:COG0840 207 TRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRElVGQVRESAeqVASASEELAA 274
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
175-223 |
8.46e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 54.18 E-value: 8.46e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 2225873610 175 RYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALK 223
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
75-444 |
1.48e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.90 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 75 AVEVLSHEELVIFGLQHKYLEEPLHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDYYEDMQAIRRL 154
Cdd:COG3850 40 RTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 155 MIQVLIFVLLSGSVIILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALK-------NVDE 227
Cdd:COG3850 120 ALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQelyaeleEEEE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 228 MRKTFVSNVSHEIQSPLTSIKGYTRAIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLDE 307
Cdd:COG3850 200 LEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 308 QIRRIVLKTEPQWQEKHILVELNLEPLTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEESNHVFRINDTGIGIP 387
Cdd:COG3850 280 LLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAG 359
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2225873610 388 DEEIPFVFDRFYKVDSSRTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFV 444
Cdd:COG3850 360 AALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGL 416
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
349-447 |
1.74e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.54 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 349 NLIVNAIRY--NKPGGSIYIN-HYQEESNHVfRINDTGIGIPDEEIPFVFDRFYkvdsSRTGvdSGSGLGLSIVKRIVML 425
Cdd:PRK11086 440 NLIENALEAvgGEEGGEISVSlHYRNGWLHC-EVSDDGPGIAPDEIDAIFDKGY----STKG--SNRGVGLYLVKQSVEN 512
|
90 100
....*....|....*....|..
gi 2225873610 426 HEGRTDCISQEGVGTTFFVRLP 447
Cdd:PRK11086 513 LGGSIAVESEPGVGTQFFVQIP 534
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
10-230 |
1.02e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 57.43 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 10 FVFIFIIGVGLSVIISYAITTHFFQNQTAFKAELNSATQGVTAIIETVDPEEHEELLPIFEDLGLAVEVLSHEELVIFGL 89
Cdd:COG2770 70 LLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 90 QHKYLEEPLHESEINTLTSRSARIIDYTDTELRRDIVTLVDVEGEPMYARITLDYYEDMQAIRRLMIQVLIFVLLSGsVI 169
Cdd:COG2770 150 ARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLAL-LL 228
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2225873610 170 ILFISRYFVRSIQQITRAAEQLTHGDFEVNLKTEREDELGQLMEQFNQMAQALKNVDEMRK 230
Cdd:COG2770 229 ALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAE 289
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-429 |
8.77e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 50.71 E-value: 8.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 320 WQEKHILVELNLEP-LTLALD-EDLMEqVWLNLIVNAIRYNKpgGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDR 397
Cdd:cd16954 14 YQRKGVSISLDISPeLRFPGErNDLME-LLGNLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQR 90
|
90 100 110
....*....|....*....|....*....|..
gi 2225873610 398 FYKVDSSRtgvdSGSGLGLSIVKRIVMLHEGR 429
Cdd:cd16954 91 GQRLDEQR----PGQGLGLAIAKEIVEQYGGE 118
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
171-446 |
8.37e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.21 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 171 LFISRYFVRSIQQITRAAEQLthgdfEVNLKTEREDELGQL--MEQFNQMAqalknvdemrktfvSNVSHEIQSPLTSIK 248
Cdd:PRK13557 122 LFVSPVYNDAGDLVYFFGSQL-----DVSRRRDAEDALRQAqkMEALGQLT--------------GGIAHDFNNLLQVMS 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 249 GYTR----AIKDGVVSVDQQDKYLGIIYDEADRLSRLSEHLL---KMTKLDQDAYPINKQPYRLDEQIRRIVlktepqwq 321
Cdd:PRK13557 183 GYLDviqaALSHPDADRGRMARSVENIRAAAERAATLTQQLLafaRKQRLEGRVLNLNGLVSGMGELAERTL-------- 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 322 EKHILVELNLEP--LTLALDEDLMEQVWLNLIVNAIRYNKPGGSIYINHYQEES----NHVFR-----------INDTGI 384
Cdd:PRK13557 255 GDAVTIETDLAPdlWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEIededLAMYHglppgryvsiaVTDTGS 334
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2225873610 385 GIPDEEIPFVFDRFYkvdsSRTGVDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTffVRL 446
Cdd:PRK13557 335 GMPPEILARVMDPFF----TTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTT--VRL 390
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-447 |
1.45e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 46.76 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 339 DEDLMEQVWLNLIVNA------IRYNKPGGSIYINHYQEEsNHVFRINDTGIGIPDEEI-----PFVFDRfykvdssrtg 407
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDG-RIVLIVCDNGKGFPREMRhratePYVTTR---------- 69
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2225873610 408 vDSGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16944 70 -PKGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
150-222 |
6.95e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 48.31 E-value: 6.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 150 AIRRLMIQVLIfVLLSGSVIIL-------FISRYFVRSIQQITRAAEQLTHGDFE-VNLKTEREDELGQLMEQFNQMAQA 221
Cdd:PRK10935 143 AERKLILLAAI-SLLGLILILTlvfftvrFTRRQVVAPLNQLVTASQQIEKGQFDhIPLDTTLPNELGLLAKAFNQMSSE 221
|
.
gi 2225873610 222 L 222
Cdd:PRK10935 222 L 222
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
179-429 |
1.90e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 46.93 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 179 RSIQQITRAAEQLTHGDFEvNLKTEREDELGQLMEQFNQMaqaLKN----VDEMRKTfVSNVSHEIQSPLTSIKGYTRAI 254
Cdd:PRK10815 217 RPIEALAKQVRELEEGERE-QLDPNPPRELTSLVRNLNRL---LKNererYTKYRTT-LTDLTHSLKTPLAVLQSTLRSL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 255 KDG-VVSVDQQDKylgIIYDEADRLSRLSEHLLKMTKLDQDAYPINKQPYRLDEQIRRIVLKTEPQWQEKHILVELNLEP 333
Cdd:PRK10815 292 RSGkQMSVEQAEP---IMLEQISRISQQIGYYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISP 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 334 LTLALDE--DLMEqVWLNLIVNAIRYNKPGGSIYInHYQEESNHVFrINDTGIGIPDEEIPFVFDRFYKVDSSRtgvdSG 411
Cdd:PRK10815 369 EITFVGEknDFME-VMGNVLDNACKYCLEFVEISA-RQTDEHLHIV-VEDDGPGIPESKRELIFDRGQRADTLR----PG 441
|
250
....*....|....*...
gi 2225873610 412 SGLGLSIVKRIVMLHEGR 429
Cdd:PRK10815 442 QGLGLSVAREITEQYEGK 459
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
305-449 |
1.76e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 43.74 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 305 LDEQIRRIVLKTEPQWQEKHILVELNLEPLTLALD----------EdlmeqvwlnLIVNAIRY---NKPGGSIYINHYQE 371
Cdd:COG3920 361 LRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADaavplglilnE---------LVTNALKHaflSGEGGRIRVSWRRE 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2225873610 372 ESNHVFRINDTGIGIPDEEIPfvfdrfykvdssrtgvDSGSGLGLSIVKRIVMLHEGRTDCISQEgvGTTFFVRLPKS 449
Cdd:COG3920 432 DGRLRLTVSDNGVGLPEDVDP----------------PARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLA 491
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
334-423 |
1.97e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.05 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2225873610 334 LTLALDEdlmeqvwlnLIVNAIRY---NKPGGSIYINHYQEESNHVFRINDTGIGIPDEEIPFVFDRfykvdssrtgvDS 410
Cdd:COG2172 35 LVLAVSE---------AVTNAVRHaygGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LA 94
|
90
....*....|...
gi 2225873610 411 GSGLGLSIVKRIV 423
Cdd:COG2172 95 EGGRGLFLIRRLM 107
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
410-447 |
6.00e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 37.56 E-value: 6.00e-03
10 20 30
....*....|....*....|....*....|....*...
gi 2225873610 410 SGSGLGLSIVKRIVMLHEGRTDCISQEGVGTTFFVRLP 447
Cdd:cd16916 141 SGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| |
