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Conserved domains on  [gi|2226057163|ref|WP_246041913|]
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DHA2 family efflux MFS transporter permease subunit [Robertmurraya kyonggiensis]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 2-419 1.17e-98

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 305.07  E-value: 1.17e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 162 LVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGW-GDVLVLTFIVAGVIFLYTFCRRQLTSAD 240
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 PLLNLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 321 IIGLIFTIPAL-WGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:TIGR00711 325 TIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404

                         410       420
                  ....*....|....*....|
gi 2226057163 400 ITVMTTSSTNHAEDLMQSGN 419
Cdd:TIGR00711 405 TTILTNRTQFHHSQLTETIN 424
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 2-419 1.17e-98

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 305.07  E-value: 1.17e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 162 LVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGW-GDVLVLTFIVAGVIFLYTFCRRQLTSAD 240
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 PLLNLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 321 IIGLIFTIPAL-WGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:TIGR00711 325 TIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404

                         410       420
                  ....*....|....*....|
gi 2226057163 400 ITVMTTSSTNHAEDLMQSGN 419
Cdd:TIGR00711 405 TTILTNRTQFHHSQLTETIN 424
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-457 2.38e-87

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 272.53  E-value: 2.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSlkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadPLL 243
Cdd:cd17503   161 ILALLLA----------------------------------------------------------------------PLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 NLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIG 323
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 324 LIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALIITVM 403
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 404 TTSSTNHAEDLMQsgnvLSKAQLSLDSAIHGTNVAYTFTLILAILALIVTLIMP 457
Cdd:cd17503   331 TNRTQFHHSRLSE----LLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-394 1.05e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 135.49  E-value: 1.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKAKLDVTSvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsad 240
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSL--------------------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 pllnLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:COG2814   201 ----RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL 276

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 321 IIGLIFTIPALWGvtdLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAI 394
Cdd:COG2814   277 LIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
4-396 3.00e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALP-DLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINA 82
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  83 TAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPL 162
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 163 VAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadpl 242
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 243 lnLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQaSRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAII 322
Cdd:pfam07690 194 --WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 323 GLIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGT 396
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK14995 PRK14995
SmvA family efflux MFS transporter;
16-398 7.03e-19

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 89.02  E-value: 7.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  16 TILNVALPDLMNQFDVSATTIQWLSTGFMLV-NGILIPVTAfLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGR 94
Cdd:PRK14995   23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVmAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  95 LIQAAGAGIIMPLLMTVVLVVY-PAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKF 173
Cdd:PRK14995  102 ALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARY 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 174 LINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGWGDVLVLTFIVAGVIFLYTFCRRQLTSADPLLNLKVFKYKTF 253
Cdd:PRK14995  182 VPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRII 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 254 tMTAIINVLLTMI-MYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIGLIFTIPALW 332
Cdd:PRK14995  262 -LSGVVMAMTAMItLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFY 340

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2226057163 333 GVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTAL 398
Cdd:PRK14995  341 GLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 2-419 1.17e-98

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 305.07  E-value: 1.17e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 162 LVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGW-GDVLVLTFIVAGVIFLYTFCRRQLTSAD 240
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 PLLNLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 321 IIGLIFTIPAL-WGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:TIGR00711 325 TIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404

                         410       420
                  ....*....|....*....|
gi 2226057163 400 ITVMTTSSTNHAEDLMQSGN 419
Cdd:TIGR00711 405 TTILTNRTQFHHSQLTETIN 424
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-457 2.38e-87

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 272.53  E-value: 2.38e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSlkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadPLL 243
Cdd:cd17503   161 ILALLLA----------------------------------------------------------------------PLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 NLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIG 323
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 324 LIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALIITVM 403
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 404 TTSSTNHAEDLMQsgnvLSKAQLSLDSAIHGTNVAYTFTLILAILALIVTLIMP 457
Cdd:cd17503   331 TNRTQFHHSRLSE----LLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 4-457 5.04e-54

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 185.45  E-value: 5.04e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSlkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadpll 243
Cdd:cd17321   161 LVALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 nlkvfkyKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIG 323
Cdd:cd17321   168 -------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 324 LIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALIITVM 403
Cdd:cd17321   241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 404 TTSSTNHAEDLMQSGNVLSKAQlsldSAIHGTNVAYTFTLILAILALIVTLIMP 457
Cdd:cd17321   321 TAGLSANLGDSGVAALLSAAAA----AFAAGFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-394 1.05e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 135.49  E-value: 1.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKAKLDVTSvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsad 240
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSL--------------------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 pllnLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:COG2814   201 ----RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL 276

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 321 IIGLIFTIPALWGvtdLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAI 394
Cdd:COG2814   277 LIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 4-398 1.37e-29

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 118.43  E-value: 1.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDvSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17502     1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17502    80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLslkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadpll 243
Cdd:cd17502   160 GLALAL-------------------------------------------------------------------------- 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 nlkvfkYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVG-VKPLAII 322
Cdd:cd17502   166 ------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2226057163 323 GLIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTAL 398
Cdd:cd17502   240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 4-457 1.32e-25

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 107.66  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17504     1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIImPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17504    81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSlkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadPLL 243
Cdd:cd17504   160 VLLAALV----------------------------------------------------------------------PLI 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 NLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASR----GFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPL 319
Cdd:cd17504   170 DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 320 AIIGLIFTIPALWGVTDLSESTTYTYLMIrtIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:cd17504   250 LLIGLVISAVGLLLLALLHSSLWALVVAL--LLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2226057163 400 ITVMTTSSTNHAedlmqSGNVLSKAqlsldsaihGTNVAYTFTLILAILALIVTLIMP 457
Cdd:cd17504   328 GAILTTYTVSIT-----SGGVPTEG---------AYVLAFLIGAALALAALLLSLLIP 371
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-231 2.63e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 105.28  E-value: 2.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:COG0477    96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGWGDVLVLTFIVAGVIFLYTF 231
Cdd:COG0477   176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
MFS_1 pfam07690
Major Facilitator Superfamily;
4-396 3.00e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALP-DLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINA 82
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  83 TAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPL 162
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 163 VAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsadpl 242
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA----------------------------------------------- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 243 lnLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQaSRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAII 322
Cdd:pfam07690 194 --WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 323 GLIFTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGT 396
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-411 1.14e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 99.17  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:COG2271    92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 PLVAIVIGLslkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlvltfivagviflytfcrrqltsad 240
Cdd:COG2271   172 LPGLLLALL----------------------------------------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 pllnlkvfkykTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVG--VKP 318
Cdd:COG2271   181 -----------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKL 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 319 LAIIGLIFTIPALWGVTDLsesTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTAL 398
Cdd:COG2271   250 VLAIGLLLAALALLLLALL---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326

                         410
                  ....*....|...
gi 2226057163 399 IITVMTTSSTNHA 411
Cdd:COG2271   327 VGYLLDATGYQAA 339
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 4-395 6.78e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 96.88  E-value: 6.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSLkFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFstagdkgwgdvlvlTFIVAGVIFLYTFCrrqltsadpll 243
Cdd:cd17325   161 LLALVLAL-LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRR--------------LLALFLAIFVLAFA----------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 nlkvfkyktftmtaiinvlltmiMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIG 323
Cdd:cd17325   215 -----------------------FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2226057163 324 LIFTIPALWGvtdLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIG 395
Cdd:cd17325   272 LLLSAVALLL---LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 2-405 7.16e-20

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 92.30  E-value: 7.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIqWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIImPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIE--HLSWRWLF--- 156
Cdd:cd06179    80 GTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFyin 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 157 IGMLPLVAIVIGLS---LKFLINVSEPSK---AKLDVTSVILSTLGFGLLLYGFSTAGDK-GWGDVLVLTFIVAGVIFLY 229
Cdd:cd06179   159 AIFNALALILLFFFyhpPPRPQLHGSSTRqklKRLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVIGGVLLI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 230 TFCRRQL--TSADPLLNLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVS 307
Cdd:cd06179   239 AFGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 308 GRLLDKVG-VKPLAIIGLIFT---IPALWGVTDLSESTTYTYLMIrtivLRIGLTFLTMPVTAGGLNALPKEFNAHGSAV 383
Cdd:cd06179   319 GLLLTKIKhIKWQLVAGFVLFtafLALLALITPDNKALAIAFSVL----AGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394

                         410       420
                  ....*....|....*....|..
gi 2226057163 384 TNTVRQVAGAIGTALIITVMTT 405
Cdd:cd06179   395 LGSARALGGAVGTAIFTSILSN 416
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-184 1.61e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 89.94  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd17474     2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHlSWRWLFigMLP 161
Cdd:cd17474    82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPF--FLL 158

                         170       180
                  ....*....|....*....|...
gi 2226057163 162 LVAIVIGLSLKFLINVSEPSKAK 184
Cdd:cd17474   159 AALIPVAFLAILFLLPEPKEKAK 181
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-208 3.04e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 89.15  E-value: 3.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:cd17324    81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAG 208
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITF 208
PRK14995 PRK14995
SmvA family efflux MFS transporter;
16-398 7.03e-19

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 89.02  E-value: 7.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  16 TILNVALPDLMNQFDVSATTIQWLSTGFMLV-NGILIPVTAfLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGR 94
Cdd:PRK14995   23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVmAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  95 LIQAAGAGIIMPLLMTVVLVVY-PAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKF 173
Cdd:PRK14995  102 ALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARY 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 174 LINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTAGDKGWGDVLVLTFIVAGVIFLYTFCRRQLTSADPLLNLKVFKYKTF 253
Cdd:PRK14995  182 VPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRII 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 254 tMTAIINVLLTMI-MYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIGLIFTIPALW 332
Cdd:PRK14995  262 -LSGVVMAMTAMItLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFY 340

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2226057163 333 GVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTAL 398
Cdd:PRK14995  341 GLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
PRK10504 PRK10504
putative transporter; Provisional
 1-285 2.81e-18

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 87.09  E-value: 2.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:PRK10504   12 LWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:PRK10504   92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKaKLDVTSVILSTLGFGLLLYGFSTAGDKGWGDVLVLTFIVAGVIFLYTFCRRQLTSAD 240
Cdd:PRK10504  172 PVGIIGAIATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNR 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2226057163 241 PLLNLKVFKYKTFTMtAIINVLLTMIMYGDM-ILLPIYLQASRGFS 285
Cdd:PRK10504  251 ALFSLKLFRTRTFSL-GLAGSFAGRIGSGMLpFMTPVFLQIGLGFS 295
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-184 4.08e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 86.09  E-value: 4.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:COG2223     8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:COG2223    88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167

                         170       180
                  ....*....|....*....|...
gi 2226057163 162 LVAIVIGLSLKFLINVSEPSKAK 184
Cdd:COG2223   168 LLLVVAVLAWLFLRDPPAGAAAA 190
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 4-399 6.53e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 82.09  E-value: 6.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 164 AIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLllygfstagdkgwgdvlvltfivagviflytfcrrqltsadpll 243
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 244 nLKVFKYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLAIIG 323
Cdd:cd06174   197 -KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2226057163 324 LIFTIPALWGVTDLSESTTYTYLMirTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:cd06174   276 GLLLMALGLALLLLAPSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-174 1.46e-16

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 81.08  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                         170
                  ....*....|....
gi 2226057163 161 PLVAIVIGLSLKFL 174
Cdd:cd17320   161 LLGLLLLLLVLLFL 174
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-169 2.76e-15

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 77.61  E-value: 2.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILN----QTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIG 77
Cdd:COG2807    17 WLLLLAIVLVALNlrpaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  78 TLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEgRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWR--WL 155
Cdd:COG2807    97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRgaLA 175

                         170
                  ....*....|....
gi 2226057163 156 FIGMLPLVAIVIGL 169
Cdd:COG2807   176 VWALLALLALLLWL 189
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-399 1.25e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 74.91  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17319     5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFigml 160
Cdd:cd17319    85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF---- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 plvaIVIGlslkflinvsepskakldvtsvilstlgfglllygfstagdkgwgdvlVLTFIVAGVIFLYtfcrrqltsad 240
Cdd:cd17319   161 ----IIEG------------------------------------------------LLGLLLAVLWWFY----------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 pllnlkvfkYKTFTMTAIINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGV---K 317
Cdd:cd17319   178 ---------LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarR 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 318 PLAIIGLIFTIPALWGVTdLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLnaLPKEFNAHGSAVTNTVRQVAGAIGTA 397
Cdd:cd17319   249 LVIIIGLLLAAVGLLLAY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADL--LPGEAAATAGGLINSGGNLGGFVAPL 325


                  ..
gi 2226057163 398 LI 399
Cdd:cd17319   326 LI 327
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 2-228 8.77e-14

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 72.61  E-value: 8.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd17323     2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:cd17323    82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 162 LVAIVIGLSLKFLINvsepskakldvtsVILSTLGFGL---LLYGFSTAGDKGWGDVLVLTFIVAGVIFL 228
Cdd:cd17323   162 ISGFCLILIFLFLPI-------------VLLLGLYVGLvyaILYLFLTAFPYVFGEVYGFSPGEVGLMYL 218
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 4-184 5.05e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 67.23  E-value: 5.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIgmLPLV 163
Cdd:cd17489    81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI--VAAV 158

                         170       180
                  ....*....|....*....|.
gi 2226057163 164 AIVIGLSLKFLINVSEPSKAK 184
Cdd:cd17489   159 LALLALLLVFLVKDPPPVAAE 179
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 52-397 5.38e-12

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 67.72  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  52 PVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAG-AGIImpLLMTVVLV-VYPAEGRGTAMGMIG 129
Cdd:cd17322    55 PPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGyTGLN--LLLTLILAdFSSLKNRGFASAIPS 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 130 LAMIFAPAIGPTLAGIVIEHLSWRWlFIGM----LPLVAIVIGLSLKFLINVSEPSKA---------------------- 183
Cdd:cd17322   133 LPYIITTWIGGNIAQAALPNSNWRW-GYGMwaiiLPLSSLPLVLCLLYMQRKARKDGEikelknqeteeqtgglsqnlvk 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 184 ---KLDVTSVILSTLGFGLLLYGFSTAG--DKGWGDVLVLTFIVAGVIFLYTFCRRQLTSA-DPLLNLKVFKYKTFTMTA 257
Cdd:cd17322   212 lfwKLDIFGVILLTAGLGLILVPLTLAGgaKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAkYPFLPFRLLKDRTILAAC 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 258 IINVLLTMIMYGDMILLPIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVG-VKPLAIIGLIFTIPALWGVTD 336
Cdd:cd17322   292 LIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIR 371

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2226057163 337 L-SESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTA 397
Cdd:cd17322   372 YrGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAA 433
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 2-174 6.60e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.83  E-value: 6.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQF-DVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17473     2 ITLLLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEhLSWRWLFIGML 160
Cdd:cd17473    82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160

                         170
                  ....*....|....
gi 2226057163 161 pLVAIVIGLSLKFL 174
Cdd:cd17473   161 -LALPVLILVLLFL 173
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-174 1.16e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.06  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALP-DLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:cd17325   201 LLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGM 159
Cdd:cd17325   281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360

                         170
                  ....*....|....*
gi 2226057163 160 LPLVAIVIGLSLKFL 174
Cdd:cd17325   361 AALLLLAAVLFLLLR 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
38-174 1.60e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 61.90  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  38 WLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYP 117
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2226057163 118 AEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFL 174
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 2-416 1.75e-11

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 65.36  E-value: 1.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVY-PAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGML 160
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 161 PLVAIVIGLSLkFLINVSepskakldvTSVILSTLGFglllygfstagdkGWGDVLVLTFivagviflYTFcrrqltsad 240
Cdd:cd17476   161 ILAAIVAVAAI-FWTSPS---------FIAVLLAVFL-------------GWASFGIWVF--------YAT--------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 241 pllnlkvfkyktftmtaiinvlltmimygdmillpIYLQASRGFSVLETGLLLLPGALLNALLSPVSGRLLDKVGVKPLA 320
Cdd:cd17476   201 -----------------------------------QYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIM 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 321 IIGLI-FTIPALWGVTDLSESTTYTYLMIRTIVLRIGLTFLTMPVTAGGLNALPKEFNAHGSAVTNTVRQVAGAIGTALI 399
Cdd:cd17476   246 AISMVaFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIA 325

                         410
                  ....*....|....*..
gi 2226057163 400 ITVmTTSSTNHAEDLMQ 416
Cdd:cd17476   326 GTV-ETSVNEDGADLLK 341
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-204 1.41e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.95  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSI-LNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:COG0738     9 ALIAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGR---GTAMGMIGLAMIFAPAIGPTLAGIVIeHLSWRWLF 156
Cdd:COG0738    89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLILLGL-SLSWHLPY 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2226057163 157 IGM-LPLVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGF 204
Cdd:COG0738   168 LILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGG 216
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-169 5.34e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 61.05  E-value: 5.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQ-FDVSATTIQWLSTGFMLVNGILIPVTA-FLMKRFSTRQLFIASMLLLFIGT 78
Cdd:cd17474   200 LLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  79 LINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIG 158
Cdd:cd17474   280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359

                         170
                  ....*....|.
gi 2226057163 159 MLPLVAIVIGL 169
Cdd:cd17474   360 GAAIALAAAVL 370
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 2-175 3.07e-09

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 58.55  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLG--SFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:TIGR00710   6 FALLLGclSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIgM 159
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA-F 164

                         170
                  ....*....|....*.
gi 2226057163 160 LPLVAIVIGLSLKFLI 175
Cdd:TIGR00710 165 LSLAGILLSALIFFIL 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-171 3.20e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 58.34  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPD-LMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQ--LFIASMLLLFIG 77
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  78 TLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFI 157
Cdd:COG2271   262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341

                         170
                  ....*....|....
gi 2226057163 158 GMLPLVAIVIGLSL 171
Cdd:COG2271   342 LLAALALLAALLAL 355
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 4-172 6.95e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 57.62  E-value: 6.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVAL----PDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLM-KRFSTRQLFIASMLLLFIGT 78
Cdd:cd17490   196 LLFFSLLAILQQMITFSTTfgftPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYC 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  79 LINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMI----GLAMIFapaiGPTLAGIVIEH--LSW 152
Cdd:cd17490   276 FLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFqaiyALGMFL----GPVLVGIISEAfgLQT 351

                         170       180
                  ....*....|....*....|
gi 2226057163 153 RWLFIGMLPLVAIVIGLSLK 172
Cdd:cd17490   352 GFFVIGVIALLAAILSLAYY 371
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 4-207 9.78e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 57.18  E-value: 9.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17478     1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEgRGTAMGMIGLAMIFAPAIGPTLAGIVIEH---LSWRWLFIGML 160
Cdd:cd17478    81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALfggLGLLILLIIPG 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2226057163 161 PLVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLYGFSTA 207
Cdd:cd17478   160 LAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFL 206
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-172 1.79e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 56.05  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALP-DLMNQFDVSATTIQWLSTGF----MLVNGILIPvtaFLMKRFSTRQLFIASMLLLF 75
Cdd:cd17330   176 LRRLLLVYFLIALAFAGLESVFSlFLKDRFGFSPSQIGLLLALVgiagILAQLLLIP---RLAKRLGERKLLRLGLLLAI 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  76 IGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWL 155
Cdd:cd17330   253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP 332

                         170
                  ....*....|....*..
gi 2226057163 156 FIGMLPLVAIVIGLSLK 172
Cdd:cd17330   333 FLLAAGLLLIALFLLSL 349
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 25-188 1.98e-08

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 56.13  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  25 LMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPG-FGFLLTGRLIQAAGAGI 103
Cdd:cd17355    29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 104 IMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFLINVSEPSKA 183
Cdd:cd17355   109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLAL 188


                  ....*
gi 2226057163 184 KLDVT 188
Cdd:cd17355   189 RAYDD 193
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 6-169 4.78e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 55.07  E-value: 4.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   6 LGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAP 85
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  86 GFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVI-EHLSWRWLFIgMLPLVA 164
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaELYSWHWVFI-VPGIIA 160


                  ....*
gi 2226057163 165 IVIGL 169
Cdd:TIGR00881 161 IIVSL 165
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
25-173 9.85e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.09  E-value: 9.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  25 LMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGII 104
Cdd:COG0738   237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2226057163 105 MPLLMTVVLVVYPAEGrGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKF 173
Cdd:COG0738   317 FPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 2-175 1.17e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.78  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd17328     2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEH-LSWRWLFIGMl 160
Cdd:cd17328    82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVT- 160

                         170
                  ....*....|....*
gi 2226057163 161 PLVAIVIGLSLKFLI 175
Cdd:cd17328   161 GVLGVLLAILLLLFV 175
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 16-167 1.21e-07

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  16 TILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINaTAPGFGFLLTGRL 95
Cdd:cd17339    16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLR-SLGGIALLFLGTA 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2226057163  96 IQAAGAGIIMPLLMTVVLVVYPaEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRW----LFIGMLPLVAIVI 167
Cdd:cd17339    95 LAGAGIAVGNVLLPSLIKRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGGGWrgalAIWALPALLALLI 169
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
 20-193 1.29e-07

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 53.73  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  20 VALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAA 99
Cdd:TIGR00891  33 LVLAEVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 100 GAGIIMPLLMTVVLVVYPAEGRGTAMGMI--GLAMIFAPAIGPTLAGIVIEHLSWRWLF-IGMLPlvaIVIGLSLKFLIN 176
Cdd:TIGR00891 113 GMGGEYGSSAAYVIESWPKHLRNKASGLLisGYAVGAVVAAQVYSLVVPVWGDGWRALFfISILP---IIFALWLRKNIP 189

                         170
                  ....*....|....*..
gi 2226057163 177 VSEPSKAKLDVTSVILS 193
Cdd:TIGR00891 190 EAEDWKEKHAGKALVRT 206
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-174 1.42e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.35  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQ-FDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:cd17473   199 VLPIYFLAFLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGM 159
Cdd:cd17473   279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLI 358

                         170
                  ....*....|....*
gi 2226057163 160 LPLVAIVIGLSLKFL 174
Cdd:cd17473   359 LGVLALVLAIVLLLL 373
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-175 1.85e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.99  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQwlSTGFMLVNGILIPVTAFLM----KRFSTRQLFIASMLLLFI 76
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQ--TGLLFAAGFLGRPIGALLFgylgDRIGRKKALILTLLLFGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  77 GTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLS----W 152
Cdd:cd17316    79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgW 158

                         170       180
                  ....*....|....*....|...
gi 2226057163 153 RWLFIGMLPLVAIVIGLSLKFLI 175
Cdd:cd17316   159 RILFLIGALPALLALLLRRRTLL 181
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-171 2.26e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILnqTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:COG2223   210 LSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPG-FGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHL-SWRWLFIG 158
Cdd:COG2223   288 LALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLV 367

                         170
                  ....*....|...
gi 2226057163 159 MLPLVAIVIGLSL 171
Cdd:COG2223   368 FAVLALVALVLTL 380
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 43-169 2.57e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  43 FMLVNGILI----PVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPA 118
Cdd:cd17489   232 FFTVYAIALllsrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2226057163 119 EGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFI--GMLPLVAIVIGL 169
Cdd:cd17489   312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLlaAVVVLLALVLYI 364
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 25-171 3.37e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.17  E-value: 3.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  25 LMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGII 104
Cdd:cd17324   225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2226057163 105 MPLLMTVVLVVYPaEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSL 171
Cdd:cd17324   305 HSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 4-208 7.27e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 51.02  E-value: 7.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLV 163
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2226057163 164 AIVIgLSLKFLINVSEPSKAKLDVTSVILS--TLGFGLLLYGFSTAG 208
Cdd:cd17477   161 ALVP-LLLTRRAAPEIEEAESISLRRLLRIapLALLGAFVAGFLEGA 206
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 4-175 8.31e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 51.20  E-value: 8.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSIL----NQTILNVALPDLMNQFDVSATTIQWLSTGF---MLVNGILIPVTAflmKRFSTRQLFIASMLLLFI 76
Cdd:TIGR00895  18 AIILSFLIMLmdgyDLAAMGFAAPAISAEWGLDPVQLGFLFSAGligMAFGALFFGPLA---DRIGRRRVLLWSILLFSV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  77 GTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLF 156
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174

                         170       180
                  ....*....|....*....|....*.
gi 2226057163 157 -IG------MLPLVAIVIGLSLKFLI 175
Cdd:TIGR00895 175 yVGgiapllLLLLLMRFLPESIDFLV 200
emrD PRK11652
multidrug transporter EmrD;
15-174 1.89e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 49.91  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  15 QTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGR 94
Cdd:PRK11652   24 QTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAAS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  95 LIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFL 174
Cdd:PRK11652  104 AIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWM 183
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 6-289 1.98e-06

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 50.03  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   6 LGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAP 85
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  86 GFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAI 165
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 166 VIGLSLKFLINvsEPSKAKLDVTSVILSTLGFGLL-LYGFSTAGDKGWGDVLVLTFIVAGVIFLYTFCrrqltsadplln 244
Cdd:TIGR00893 161 WGVLWLKFIPD--PPQKAKWLTEEEKYIVVGGLLAeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFL------------ 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2226057163 245 lkvfkyktftmtaiINVLLTMIMYgdmiLLPIYLQASRGFSVLET 289
Cdd:TIGR00893 227 --------------VNIGLGFFLT----WFPTYLVQERGLSILEA 253
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 18-180 3.11e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 49.19  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  18 LNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQ 97
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  98 AAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIgMLPLVAIVIGLSLKFLINV 177
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFL-VPGIVGLVVAIILFFFLRD 180


                  ...
gi 2226057163 178 SEP 180
Cdd:cd17312   181 SPP 183
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 21-231 6.60e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 48.51  E-value: 6.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  21 ALPDLMNqfDVSATTIQWL-STGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGR--LIQ 97
Cdd:pfam06609  66 ALPNILQ--DIGQSENQGLfSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMtlLGV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  98 AAGAGIIMPLLMtvvlvvypAEGRGTAMGMIGLAMIFAPAI-----GPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLK 172
Cdd:pfam06609 144 AAGPAGASPLFI--------GELMSNKTKFLGLLIVSAPTIamngaGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIII 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2226057163 173 FL-------INVSEPSK----AKLDVTSVILSTLGFGLLLYGFSTAG--DKGWGDVLVLTFIVAGVIFLYTF 231
Cdd:pfam06609 216 WYhppsfaqLHGKKARKrdelAKLDWIGIFLVIAGTSLFLLGVSWGGkpNNPWNSAKIIGLISSGAGSLVIF 287
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 16-167 7.38e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.97  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  16 TILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRL 95
Cdd:cd17365    16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163  96 IQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFI--GMLPLVAIVI 167
Cdd:cd17365    96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLlgGVPPLILLPL 169
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 60-285 9.33e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 48.16  E-value: 9.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  60 RFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGmiglAMIFAPAIG 139
Cdd:PRK03893   81 RYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASG----FLISGFSIG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 140 PTLAG----IVIEHLSWRWLF-IGMLPlvaIVIGLSLKFLI----------NVSEPSKAKLDV--------TSVILSTLG 196
Cdd:PRK03893  157 AVVAAqvysLVVPVWGWRALFfIGILP---IIFALWLRKNLpeaedwkekhAGKAPVRTMVDIlyrgehriINILLTLAA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 197 FGLLLYGFSTAGDKGWGdVLVLTFIVAGVI--FLYTFCRRqltsadpllnlkvfkyKTFTMTAIINVLLTMIMYGDMI-- 272
Cdd:PRK03893  234 AAALWFCFAGNLQNAAI-VAVLGLLCAAIFisFMVQSSGK----------------RWPTGVMLMVVVLFAFLYSWPIqa 296

                         250
                  ....*....|...
gi 2226057163 273 LLPIYLQASRGFS 285
Cdd:PRK03893  297 LLPTYLKTDLGYD 309
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
22-181 9.42e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.95  E-value: 9.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  22 LPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRF-STRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAG 100
Cdd:COG2807   238 LPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLgDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQ 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 101 AGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHL-SWRWLFIGMLPLVAIVIGLSLKFLINVSE 179
Cdd:COG2807   318 GGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGRPYVE 397


                  ..
gi 2226057163 180 PS 181
Cdd:COG2807   398 DA 399
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 37-171 1.20e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.22  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  37 QWLSTGFMLVNGILI----PVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVV 112
Cdd:cd17329   235 ESLLGLLLALNALLIvllqFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2226057163 113 LVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHL--SWRWLFIGMLPLVAIVIGLSL 171
Cdd:cd17329   315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLgpGLPWLILAALGLIAAALLLGL 375
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 28-167 2.04e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 46.77  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  28 QFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPL 107
Cdd:cd17370   228 ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESI 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2226057163 108 LMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFI--GMLPLVAIVI 167
Cdd:cd17370   308 ERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLfsAVLALIALLL 369
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 19-174 2.55e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 46.45  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  19 NVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGF-GFLLTGRLIQ 97
Cdd:cd17353    23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLpLLFLGYGVLG 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2226057163  98 AAGAGIIMPLLMTVVLVVYPaEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFL 174
Cdd:cd17353   103 GIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-169 3.20e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLM-NQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:COG2211   230 FLLLLLAYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPG--FGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAE-------GRGTAMGMIGLAMIFAPAIGPTLAGIVI--- 147
Cdd:COG2211   310 LLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLalf 389

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2226057163 148 ----------EHLSWRWLFIGMLPLVAIVIGL 169
Cdd:COG2211   390 gyvagaaqspSALTGIRLLFFLLPAVLLLLAA 421
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 4-202 6.42e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 6.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd06173     4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFG-----FLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIg 158
Cdd:cd06173    84 LALLGslslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA- 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2226057163 159 mLPLVAIVIGLSLKFLINVSEPSKAKLDVTSVILSTLGFGLLLY 202
Cdd:cd06173   163 -INALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLR 205
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 4-173 6.71e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 6.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   4 LLLGSFLSILNQTILNVALPDL-MNQFDVSATTIQWLSTGF---MLVNGILIPVtafLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:cd06173   213 LLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLAAFgvgALLGALLLGR---LSKRRRRGRLLLIGALLLGLALL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 INATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGM 159
Cdd:cd06173   290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369

                         170
                  ....*....|....
gi 2226057163 160 LPLVAIVIGLSLKF 173
Cdd:cd06173   370 GALLLLAALLLLLL 383
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 25-174 1.24e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.10  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  25 LMNQFDVSATTIQWLST---GFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGA 101
Cdd:cd17319   206 LKQARGFSLKQVGLLAAipfLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2226057163 102 GIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHL-SWRWLFIgMLPLVAIVIGLSLKFL 174
Cdd:cd17319   286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFL-FLAAVALLAALLVLLL 358
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 6-171 1.45e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.10  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   6 LGSFLSILNQTILNVALPDLMNQFDVSATTIQW-LSTGFMLVNGILIPVTA-FLMKRFSTRQLFIASMLLLFIGTLINAT 83
Cdd:cd17315     4 LGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQgLVVSSLLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLSAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  84 APGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTaMG-----MIGLAMIFAPAIGPTLAGIVIEhlSWRWLFIG 158
Cdd:cd17315    84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGA-LGtlnqlMITFGILLAYLLGLALSLSPPG--WWRLMFAL 160

                         170
                  ....*....|...
gi 2226057163 159 MLPLVAIVIGLSL 171
Cdd:cd17315   161 AAVPALLQLLLMF 173
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 3-148 2.97e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 43.07  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   3 VLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI-- 80
Cdd:pfam13347 228 ILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALal 307

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2226057163  81 ----NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGR---GTAMGMIGLAMIFAPAIGPTLAGIVIE 148
Cdd:pfam13347 308 llgpNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKrreGTFFAMWSFISKLATGVGLGVSGLLLS 382
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 22-167 4.56e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 42.31  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  22 LPDLMNQFDVSATTIQWLSTGFMLvnGILIPV--TAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAA 99
Cdd:cd17333    19 GPSLEEAFNLNVADVSVIFSSQNA--GYLIGSllAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2226057163 100 GAGIIMPLLMTVVLVVYPaEGRGTAMGMIGLAMIFAPAIGPTLAG-IVIEHLSWRWLFIGMLPLVAIVI 167
Cdd:cd17333    97 GAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLA 164
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 1-169 6.38e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.78  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17359     3 SLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGM--------IGLAMIFAPAIGPTLAGIVIEHLSW 152
Cdd:cd17359    83 SAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGW 162

                         170
                  ....*....|....*...
gi 2226057163 153 RWLF-IGMLPLVAIVIGL 169
Cdd:cd17359   163 RWMLgLEAIPAILFLLGM 180
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 2-169 8.44e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.79  E-value: 8.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQ----FDVSATTIQWLsTGFMLVNGILIPVTA-FLMKRFSTRQLFIASMLLLFI 76
Cdd:cd17358     5 FVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWF-GSLLTLGALIGALLSgKLADRIGRKRTLLISAIPCIL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  77 GTLINATAPGFGFLLTGRLIQAAGAGIIMpllmtVVLVVYPAE-----GRGTAMGMIGLAMifapAIGPTLAGIVIEHLS 151
Cdd:cd17358    84 GWLLIAFAKDVWMLYLGRFLAGFGGGAAS-----VVVPVYIAEiapknVRGALGSLNQLLV----NIGILLGYVLGSFLP 154

                         170
                  ....*....|....*....
gi 2226057163 152 WRWL-FIGMLPLVAIVIGL 169
Cdd:cd17358   155 WRTLaLIGAIPPVVFLILL 173
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 3-174 9.51e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.38  E-value: 9.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   3 VLLLGSFLS-ILNQTILN---VALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGT 78
Cdd:cd17352     3 VVVFASFLVnFFTDGILNsfgVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  79 LINATAPGFGFL-LTGRLIQAAGAGIIMPLLMTVVlVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRW--L 155
Cdd:cd17352    83 LLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIV-GQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGalL 161

                         170
                  ....*....|....*....
gi 2226057163 156 FIGMLPLVAIVIGLSLKFL 174
Cdd:cd17352   162 ILGGLCLNLCVCGLLLRLL 180
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 22-145 1.40e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.70  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  22 LPDLMNQF----DVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIq 97
Cdd:cd17388    22 LPTLLREFvgdsADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRII- 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2226057163  98 AAGAGIIMPLLMTVVLVVYPAEGRGTAMGMI----GLAMIFAPAIGPTLAGI 145
Cdd:cd17388   101 AGITGATGAVAAAYIADVTPPEQRARNFGLLgaafGLGFIAGPALGGLLGEI 152
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 60-179 1.69e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 40.66  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  60 RFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGA--GIIMPLLMTVVlvvyPAEGRGTAMGMIGLAMIFAPA 137
Cdd:cd17472    58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAisSVVMALLADLT----REENRTKAMALIGASIGIAFA 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2226057163 138 IGPTLAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFLINVSE 179
Cdd:cd17472   134 ISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK 175
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 52-175 4.01e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 39.56  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  52 PVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMpLLMTVVLVVYPAEGRGTAMGMIGLA 131
Cdd:cd17389    82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALIGVA 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2226057163 132 M----IFAPAIGptlAGIVIEHLSWRWLFIGMLPLVAIVIGLSLKFLI 175
Cdd:cd17389   161 FslgfIIGPMIG---AYFASFTRSLGEVFFSMPALFALVLALADLLFI 205
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
68-189 4.44e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 39.23  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  68 IASMLLLFIGTLINATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVI 147
Cdd:PRK10473   72 IPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIM 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2226057163 148 EHLSWRWLFIGMLPLVAIVIGLSLkFLINVSEPSKAKLDVTS 189
Cdd:PRK10473  152 LKFPWQSLFYTMAAMGILVLLLSL-FILKETRPARAPAASSK 192
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 24-178 4.45e-03

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 39.35  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  24 DLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAPGFGFL-LTGRLIQaaGAG 102
Cdd:cd17422    28 DLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMyLTIGIIS--GLG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163 103 IIMPLLMTVVLVVYPAEGR---GTAMGMIG---LAMIFAPAIGPtlagiVIEHLSWRW--LFIGMLPLVAIVIGLSLKFL 174
Cdd:cd17422   106 YCFTFLPTVTILSQYFKKRrslVTAIASTGecfAVFAFAPAFTA-----LKESIGWRYclLVVGALQLNIVVCGALLRVL 180


                  ....
gi 2226057163 175 INVS 178
Cdd:cd17422   181 KEPG 184
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-169 5.10e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   1 MFVLLLGSFLSILNQTILNVALPDLMNQ-FDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTL 79
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  80 I--NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMI----GLAMIFAPAIGPTLAGIVIEHLSWR 153
Cdd:cd17316   259 PlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSynlgRLGGGGAPPLIALLLASTGGTGVPA 338

                         170
                  ....*....|....*.
gi 2226057163 154 WLFIGMLpLVAIVIGL 169
Cdd:cd17316   339 LILALLA-IVALIVAL 353
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 3-169 6.13e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   3 VLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINA 82
Cdd:cd17477   192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  83 TAPGFGFLLTGRLIQAAGAGIIM-PLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWRWLFIGMLP 161
Cdd:cd17477   272 LVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAA 351


                  ....*...
gi 2226057163 162 LVAIVIGL 169
Cdd:cd17477   352 VALLFLLF 359
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 6-172 6.23e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.82  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   6 LGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLINATAP 85
Cdd:cd17371     6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  86 GFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLA----MIFAPAIGPTLAGIVIEHLSWRWLFI-GML 160
Cdd:cd17371    86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFLlGAL 165

                         170
                  ....*....|...
gi 2226057163 161 P-LVAIVIGLSLK 172
Cdd:cd17371   166 PaLLVLFIRRFVK 178
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 2-174 7.60e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.55  E-value: 7.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGILIPVTAFLMKRFSTRQLFIASMLLLFIGTLIN 81
Cdd:cd17314     6 YVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  82 ATAPGFGFLL-TGRLIQAAGAGIIMPLLMTVVLVVYPaEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHLSWR--WLFIG 158
Cdd:cd17314    86 SYVFNSFPLSyACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLAlvYTILG 164

                         170
                  ....*....|....*.
gi 2226057163 159 MLPLVAIVIGLSLKFL 174
Cdd:cd17314   165 ILAAIVLSVVSLLGFK 180
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 2-172 9.46e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 38.35  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163   2 FVLLLGSFLSILNQTILNVALPDLMNQFDVSATTIQWLSTGFMLVNGIL-IPVTAFLMKRFSTRQLFIASMLLLFIGTLI 80
Cdd:cd17472   197 LRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILmVPFVIYAEKKGKMKQVFVSSILLIAVGFLL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2226057163  81 -NATAPGFGFLLTGRLIQAAGAGIIMPLLMTVVLVVYPAEGRGTAMGMIGLAMIFAPAIGPTLAGIVIEHL--SWRWLFI 157
Cdd:cd17472   277 lLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLgySSVFLTI 356

                         170
                  ....*....|....*
gi 2226057163 158 GMLPLVAIVIGLSLK 172
Cdd:cd17472   357 LILALLWLLVSFLLP 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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