|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
614-974 |
3.81e-82 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 272.61 E-value: 3.81e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 614 RLNGLAREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPPWNelLGRILAEPASQ 693
Cdd:COG5000 77 QLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELD--LAELLREALER 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 694 LYKQPVTLS-GGQRFLSLHKAERQDErathgGTVILVEDHSEmkwledeLVHAARLASIGQLAAGVAHEIGNPITGISSL 772
Cdd:COG5000 155 GWQEEIELTrDGRRTLLVRASPLRDD-----GYVIVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 773 AQNLRY------DTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRhvtgAAFQPVSMAEVTDEALHLIHLARSGEDV 846
Cdd:COG5000 223 AERLRRkladklEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDI 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 847 VFENRCPAT-PRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKP 925
Cdd:COG5000 299 RLELDLDPDlPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2230564503 926 agEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHREDA 974
Cdd:COG5000 379 --KGTGLGLAIVKKIVEEHGGTIELESRPGG---GTTFTIRLPLAEEAE 422
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
625-976 |
7.77e-79 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 261.32 E-value: 7.77e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 625 LRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPP---PWNELLGRILAEPASQLYKQpVTL 701
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPedsPLRELLERALAEGQPVTERE-VTL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 702 ---SGGQRFLSLHKAERQDErATHGGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRY 778
Cdd:COG3852 84 rrkDGEERPVDVSVSPLRDA-EGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLER 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 779 DTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRhvtgAAFQPVSMAEVTDEALHLIHlARSGEDVVFE-NRCPATPR 857
Cdd:COG3852 163 ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERVLELLR-AEAPKNIRIVrDYDPSLPE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 858 VTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPE----------GERLRVTVTDEGHGIDERVRDHLFEPFTTTKPag 927
Cdd:COG3852 238 VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE-- 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2230564503 928 EGTGLGLPLVYSIVAEHGGQIDIESPPagqTHGTRILLWLPLHREDAES 976
Cdd:COG3852 316 KGTGLGLAIVQKIVEQHGGTIEVESEP---GKGTTFRIYLPLEQAEEEP 361
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
607-970 |
1.17e-75 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 252.80 E-value: 1.17e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 607 RLEDYRPRLNGLAREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPPWNELLGRI 686
Cdd:COG4191 3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 687 LAEPASQLYKQPVTLSGGQRFLSLHKAERQDERATHggtviLVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPI 766
Cdd:COG4191 83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITE-----LERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 767 TGISSLAQNLRYDT----DDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRhvtgAAFQPVSMAEVTDEALHLIHLARS 842
Cdd:COG4191 158 AAILGNAELLRRRLedepDPEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 843 GEDVVFENRCPAT-PRVTGDAQRLQQVMINLLGNARDA--SAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEP 919
Cdd:COG4191 234 ARGIEVELDLPPDlPPVLGDPGQLEQVLLNLLINAIDAmeEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEP 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2230564503 920 FTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLH 970
Cdd:COG4191 314 FFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGG---GTTFTITLPLA 361
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
642-970 |
1.31e-53 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 190.12 E-value: 1.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 642 AFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPPWNELLGRILAEPASQLYKQPVTLSGGQRFLSLHKAERQDERAT 721
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 722 HGGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRyDTDDPELRETADQIQQLTDRVSR 801
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL-EELDEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 802 IVGSLVGFAHGGRHVTGAAFQPVSMAEVTDEALHLIHLARSGEDVVFENRCPATP-RVTGDAQRLQQVMINLLGNARDAS 880
Cdd:COG0642 160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 881 APGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA--GEGTGLGLPLVYSIVAEHGGQIDIESPPAGqt 958
Cdd:COG0642 240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrGGGTGLGLAIVKRIVELHGGTIEVESEPGK-- 317
|
330
....*....|..
gi 2230564503 959 hGTRILLWLPLH 970
Cdd:COG0642 318 -GTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
734-972 |
2.94e-50 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 177.41 E-value: 2.94e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 734 EMKWLEDELVHAARLASigQLAAGVAHEIGNPITGISSLAQNLR--YDTDDPELRETADQIQQLTDRVSRIVGSLVGFAH 811
Cdd:COG2205 1 ELEEALEELEELERLKS--EFLANVSHELRTPLTSILGAAELLLdeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 812 GGRHVTGAAFQPVSMAEVTDEALHLIHLARSGEDVVFENRCPAT-PRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAA 890
Cdd:COG2205 79 LESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 891 EPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAG--EGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLP 968
Cdd:COG2205 159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGG---GTTFTVTLP 235
|
....
gi 2230564503 969 LHRE 972
Cdd:COG2205 236 LAES 239
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
616-975 |
6.57e-47 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 178.24 E-value: 6.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 616 NGLAREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTL---PPPWNELLGRILAEPAS 692
Cdd:PRK11360 251 NNLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfppNTPFASPLLDTLEHGTE 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 693 QLYKQPV-TLSGGQRFLSLHKAERQDERATHGGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISS 771
Cdd:PRK11360 331 HVDLEISfPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRG 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 772 LAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVtgaaFQPVSMAEVTDEALHLIHLARSGEDVVFE-N 850
Cdd:PRK11360 411 YVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQ----WQPVSLNALVEEVLQLFQTAGVQARVDFEtE 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 851 RCPATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGE-RLRVTVTDEGHGIDERVRDHLFEPFTTTKPAgeG 929
Cdd:PRK11360 487 LDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK--G 564
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2230564503 930 TGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHREDAE 975
Cdd:PRK11360 565 TGLGLALSQRIINAHGGDIEVESEPGV---GTTFTLYLPINPQGNQ 607
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
636-969 |
1.18e-45 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 168.43 E-value: 1.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 636 LPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGA------HRDTLPPPWN-ELLGRILaepasQLYKQPVTLSGGQRFL 708
Cdd:COG5807 36 ILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKtfveekCILKDEQLYNkEAFDRIE-----ISYLTKNGEFDEIIYP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 709 SLHKAERQDerathgGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRYDTDDPELRET 788
Cdd:COG5807 111 IYYKDGVIL------GLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 789 ADQIQQLTDRVSRIVGSLVGFAHGGRhvtgAAFQPVSMAEVTDEalhLIHLARSG---EDVVFE-NRCPATPRVTGDAQR 864
Cdd:COG5807 185 FNIIISEIDRINTIITELLVLSKPKK----FNFKKLNLNDVLED---VIALLSTEailKNISIKyDLADDEPVINGDKNQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKpaGEGTGLGLPLVYSIVAEH 944
Cdd:COG5807 258 LKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTK--EEGTGLGLSICKKIIEEH 335
|
330 340
....*....|....*....|....*
gi 2230564503 945 GGQIDIESPPAGqthGTRILLWLPL 969
Cdd:COG5807 336 NGTIEVESKPGK---GTTFTIYLPL 357
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
753-972 |
3.29e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 165.11 E-value: 3.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 753 QLAAGVAHEIGNPITGISSLAQNLRYD--TDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVTGAAFQPVSMAEVT 830
Cdd:COG5002 167 EFVANVSHELRTPLTSIRGYLELLLDGaaDDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 831 DEALHLIHLARSGEDVVFENRCPATP-RVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGID 909
Cdd:COG5002 247 EEVVEELRPLAEEKGIELELDLPEDPlLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIP 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2230564503 910 ERVRDHLFEPFTTTKPA----GEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHRE 972
Cdd:COG5002 327 EEDLPRIFERFYRVDKSrsreTGGTGLGLAIVKHIVEAHGGRIWVESEPGK---GTTFTITLPLARE 390
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
631-969 |
4.08e-42 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 161.82 E-value: 4.08e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 631 RTLTR-LPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAH-RDTLPPPWNELLGRILAEPA-----SQLYKQPVTLSG 703
Cdd:COG5805 160 QTLIEnSPDLICVIDTDGRILFINESIERLFGAPREELIGKNlLELLHPCDKEEFKERIESITevwqeFIIEREIITKDG 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 704 GQRFLSLHKAERQDERATHGGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRydtddP 783
Cdd:COG5805 240 RIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQ-----P 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 784 ELRETADQIQQLTDRVSR---IVGSLVGFAHGGRHVTGA-----AFQPVSMAEVTDEALHLIHLARSGEDVVfenrcpat 855
Cdd:COG5805 315 GIEDKEEYFDIMLSELDRiesIISEFLALAKPQAVNKEKenineLIQDVVTLLETEAILHNIQIRLELLDED-------- 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 856 PRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPagEGTGLGLP 935
Cdd:COG5805 387 PFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE--KGTGLGLM 464
|
330 340 350
....*....|....*....|....*....|....
gi 2230564503 936 LVYSIVAEHGGQIDIESppaGQTHGTRILLWLPL 969
Cdd:COG5805 465 VSYKIIENHNGTIDIDS---KVGKGTTFTITLPL 495
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
625-952 |
5.04e-42 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 161.30 E-value: 5.04e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 625 LRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPP-----WNELLGRILA-EPASQLYKQP 698
Cdd:COG5809 139 SEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSddqenVAAFISQLLKdGGIAQGEVRF 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 699 VTLSGGQRFLSLHKAERQDERATHGGtVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRY 778
Cdd:COG5809 219 WTKDGRWRLLEASGAPIKKNGEVDGI-VIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKD 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 779 DTDDpELRETADQIQQLTDRVSRIVGSLVGFA--HGGRhvtgaaFQPVSMAEVTDEALHLIHLARSGEDVVFENRCPAT- 855
Cdd:COG5809 298 TIDE-EQKTYLDIMLSELDRIESIISEFLVLAkpQAIK------YEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDi 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 856 PRVTGDAQRLQQVMINLLGNARDASAPGGRVIV-AAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPagEGTGLGL 934
Cdd:COG5809 371 PDILGDENQLKQVFINLLKNAIEAMPEGGNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGL 448
|
330
....*....|....*...
gi 2230564503 935 PLVYSIVAEHGGQIDIES 952
Cdd:COG5809 449 MVSYKIIEEHGGKITVES 466
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
44-487 |
1.55e-39 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 153.09 E-value: 1.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 44 LGVYASAWAIHGTLEQADRSGYGYLAYYLGAA-GAFLLAPMLLVPIQRMAHTYqlasLADLFAFRFRSRWVGTLVTLVSL 122
Cdd:cd10322 47 AATWISAGSFVGVAGLAYTYGLSAIWYILGAAlGALLLALFLAPRLRRLGKTT----IPETILERYYSKGLRLLVAIIII 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 123 LAVLPLLALQMQTLGNAIRLLSGSAsqAWLAPGLSALIALFAILFGarhthlnarqdGLLAAI---ALESVVKLGAMLAL 199
Cdd:cd10322 123 IALIPYLALQLIGGGYILSTLLGIP--YTVAVIIAAVIVILYTVFG-----------GMRAVAwtdVIQGIVMLIGVLVA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 200 GAVALFGIF-DGPGDLQSWLDgPGHLAQAETHPLAPAQWRTLLMLFFAAAFLMPHMFHITFAEPlGRRTLLRAAWVMPLF 278
Cdd:cd10322 190 AIFILSKVGgGGFSALAAALP-ALLLALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAAK-DEKTARRAFLLAGLL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 279 LLLMALPVPLILWGAQRLGVDASLTGSAYLAFGLS-SSWWIGALTFIAGLAAASGTMIIISLALSGMILNHLVLVAHPPI 357
Cdd:cd10322 268 LLLIGFLVALIGLAARALFPDLENPDLALPTLINSlLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPK 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 358 AQPdlyRWLRWLRRALIAAVIGGGWLFYRLVGVhhDLSSLAMASFVGMAQCLPGMLALLYWPGANRKGMVTGLVVGVAIW 437
Cdd:cd10322 348 ASD---KKLLRVSRIAVVVVGVLALLLALLPPS--ILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVT 422
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 2230564503 438 LAGLWpSLLGGAPWLPPIppglealadepdwylvtLVSLAANVLSFILVS 487
Cdd:cd10322 423 LVWLL-LPLASPLGIDPI-----------------IPALLVSLIVFVVVS 454
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
738-969 |
1.17e-38 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 150.71 E-value: 1.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 738 LEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRYDT-DDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRhv 816
Cdd:PRK10364 224 LQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERApAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH-- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 817 tgAAFQPVSMAEVTDEALHLIHL-ARSGEDVVFENRCPATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGE 895
Cdd:PRK10364 302 --LALQAVDLNDLINHSLQLVSQdANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2230564503 896 RLRVTVTDEGHGIDERVRDHLFEPFTTTKpaGEGTGLGLPLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLPL 969
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVASQEG---KGATFTLWLPV 448
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
474-972 |
5.21e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 140.69 E-value: 5.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 474 VSLAANVLSFILVSLATRTSAGERAAAEACSVDAVVRPMRLPLVAANGLEIKRHLsRALGQEVAEREVERALAALQMSPL 553
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLL-LSLLALLLLLLLLLLLLLVLAALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 554 DGRPYALRRLRDRIQANLSGLMGPSVAQDIVDRFLPYRQDGPGATEDIHFVENRLEDYRPRLNGLAREIDGLRRYHRRTL 633
Cdd:COG4251 80 LLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 634 TRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPPWNELLGRILAEPASQLYKQPVTLSGGQRFLSLHKA 713
Cdd:COG4251 160 LLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 714 ERQDERATHGGTVILVEDHSEMKWLEDELV-HAARLASI----GQLAAGVAHEIGNPITGISSLAQNL--RY-DTDDPEL 785
Cdd:COG4251 240 LLILLLLLLILVLELLELRLELEELEEELEeRTAELERSneelEQFAYVASHDLREPLRKISGFSQLLeeDYgDKLDEEG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 786 RETADQIQQLTDRVSRIVGSLVGFAHGGRhvTGAAFQPVSMAEVTDEALHLIHLARSGEDVVFEnrCPATPRVTGDAQRL 865
Cdd:COG4251 320 REYLERIRDAAERMQALIDDLLAYSRVGR--QELEFEPVDLNELLEEVLEDLEPRIEERGAEIE--VGPLPTVRGDPTLL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 866 QQVMINLLGNARDASAPG--GRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTT--TKPAGEGTGLGLPLVYSIV 941
Cdd:COG4251 396 RQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIV 475
|
490 500 510
....*....|....*....|....*....|.
gi 2230564503 942 AEHGGQIDIESPPaGQthGTRILLWLPLHRE 972
Cdd:COG4251 476 ERHGGRIWVESEP-GE--GATFYFTLPKAPA 503
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
860-969 |
4.27e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.22 E-value: 4.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 860 GDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKP---AGEGTGLGLPL 936
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|...
gi 2230564503 937 VYSIVAEHGGQIDIESPPAGqthGTRILLWLPL 969
Cdd:smart00387 81 VKKLVELHGGEISVESEPGG---GTTFTITLPL 110
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
738-984 |
2.66e-33 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 138.66 E-value: 2.66e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 738 LEDELVHAARLASIGQLAAGVAHEIGN---PITGISSLAQN-LRydtDDPELRETADQIQQLTDRVSRIVGSLVGFAHGG 813
Cdd:PRK13837 437 LERRLEHARRLEAVGTLASGIAHNFNNilgAILGYAEMALNkLA---RHSRAARYIDEIISAGARARLIIDQILAFGRKG 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 814 RHVTgaafQPVSMAEVTDEALHLIHLArSGEDVVFENRCPATP-RVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAE- 891
Cdd:PRK13837 514 ERNT----KPFDLSELVTEIAPLLRVS-LPPGVELDFDQDQEPaVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSr 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 892 --------------PEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAgeGTGLGLPLVYSIVAEHGGQIDIESPPAgq 957
Cdd:PRK13837 589 aklrapkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAG--GTGLGLATVHGIVSAHAGYIDVQSTVG-- 664
|
250 260
....*....|....*....|....*...
gi 2230564503 958 tHGTRILLWLPL-HREDAESTDEPDPDR 984
Cdd:PRK13837 665 -RGTRFDVYLPPsSKVPVAPQAFFGPGP 691
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
865-967 |
1.28e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 116.16 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA--GEGTGLGLPLVYSIVA 942
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSreGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|....*
gi 2230564503 943 EHGGQIDIESPPAGqthGTRILLWL 967
Cdd:cd00075 81 AHGGRITVESEPGG---GTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
860-971 |
1.05e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 110.92 E-value: 1.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 860 GDAQRLQQVMINLLGNARDASAPGGRVIVAAEpEGERLRVTVTDEGHGIDERVRDHLFEPFTTT-KPAGEGTGLGLPLVY 938
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|...
gi 2230564503 939 SIVAEHGGQIDIESPPAGqthGTRILLWLPLHR 971
Cdd:pfam02518 80 KLVELLGGTITVESEPGG---GTTVTLTLPLAQ 109
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
865-968 |
1.10e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 102.46 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAE---------------PEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEG 929
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKG 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 2230564503 930 TGLGLPLVYSIVAEHGGQIDIESPPaGQthGTRILLWLP 968
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEP-GV--GTTVRIYLP 116
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
739-952 |
1.36e-25 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 113.24 E-value: 1.36e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 739 EDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRYDT---DDPELRETADQIQQLTDRVSRIVGSLVGFAHGGrh 815
Cdd:COG4192 421 QDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALeqeNYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKS-- 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 816 vtGAAFQPVSMAEVTDEALHLIHLARSGEDVVFEnrCPATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGE 895
Cdd:COG4192 499 --DTPLQPVDLRQVIEQAWELVESRAKPQQITLH--IPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAE 574
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2230564503 896 RLRVTVTDEGHGIDerVRDHLFEPFTTTKPAgeGTGLGLPLVYSIVAEHGGQIDIES 952
Cdd:COG4192 575 NLRVAISDNGNGWP--LVDKLFTPFTTTKEV--GLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
618-972 |
1.38e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 110.32 E-value: 1.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 618 LAREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIpgesvigahrDTLPPPWNELLGRILAEPAsqlYKQ 697
Cdd:COG3290 75 LLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL----------DAIGRPIDEVLAEVLETGE---RDE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 698 PVTLSGGQRFLSLHKAERQDERAthgGTVILVEDHSEMKWLEDELVHAARLASIgqLAAgVAHEIGNPITGISSLAQNLR 777
Cdd:COG3290 142 EILLNGRVLVVNRVPIRDDGRVV---GAVATFRDRTELERLEEELEGVKELAEA--LRA-QRHDFRNHLHTISGLLQLGE 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 778 YDTDDPELRETADQIQQLTDRVSRIVGS--LVGFAHG------GRHVTgaafqpvsmAEVtDEALHLIHLARSGEDVVfe 849
Cdd:COG3290 216 YDEALEYIDEISEELQELIDSLLSRIGNpvLAALLLGkaararERGID---------LTI-DIDSDLPDLPLSDTDLV-- 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 850 nrcpatpRVTGdaqrlqqvmiNLLGNARDASA----PGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKP 925
Cdd:COG3290 284 -------TILG----------NLLDNAIEAVEklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2230564503 926 aGEGTGLGLPLVYSIVAEHGGQIDIESPPagqTHGTRILLWLPLHRE 972
Cdd:COG3290 347 -GEGRGLGLALVKQIVEKYGGTIEVESEE---GEGTVFTVRLPKEGE 389
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-969 |
2.52e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 101.34 E-value: 2.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEH 944
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|....*
gi 2230564503 945 GGQIDIESPPAGqthGTRILLWLPL 969
Cdd:cd16943 84 GGTIRVASVPGG---GTRFTIILPI 105
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
739-982 |
3.67e-25 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 110.92 E-value: 3.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 739 EDELVHAARLASIGQLAAGVAHEIGN---PITG-ISSLAQNLRYDTDDPE-LRETADQIQQLTDRVSRIVGSLVGFAHG- 812
Cdd:PRK13557 151 EDALRQAQKMEALGQLTGGIAHDFNNllqVMSGyLDVIQAALSHPDADRGrMARSVENIRAAAERAATLTQQLLAFARKq 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 813 ---GRHVT--GAAFQPVSMAEVTdealhlihlarSGEDVVFENRC-PATPRVTGDAQRLQQVMINLLGNARDASAPGGRV 886
Cdd:PRK13557 231 rleGRVLNlnGLVSGMGELAERT-----------LGDAVTIETDLaPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRV 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 887 IVAAE---------------PEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIE 951
Cdd:PRK13557 300 TIRTRnveiededlamyhglPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIY 379
|
250 260 270
....*....|....*....|....*....|.
gi 2230564503 952 SPPAgqtHGTRILLWLPLHREDAESTDEPDP 982
Cdd:PRK13557 380 SEVG---EGTTVRLYFPASDQAENPEQEPKA 407
|
|
| T2SS_HK |
NF038348 |
histidine kinase; |
738-969 |
1.96e-24 |
|
histidine kinase;
Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 109.27 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 738 LED---ELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNL-------------------RYDTD----------DPEL 785
Cdd:NF038348 311 LEEthvQLLQSEKLASIGQLAAGVAHEINNPIGFVSANLNTLkgwvhslldviaaqeaatpAHAAQtraplaaagrDADL 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 786 RETADQIQQLTD-------RVSRIVGSLVGFAHGGrhvtGAAFQPVSMAEVTDEALHLIH-LARSGEDVVFENrcPATPR 857
Cdd:NF038348 391 DYVRGDIMTLIDesidgamRVRRIVQDLRDFSRPS----GDEWSFADLHAGLESTLNVVHnELKYKADVVREY--GDLPL 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 858 VTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEGTGLGLPLV 937
Cdd:NF038348 465 VECNAAQLNQVFMNLLVNAAQAIPGRGTITIRTTCDGDHASIAISDTGKGIPPDVMGRIFDPFFTTKPVGQGTGLGLSIS 544
|
250 260 270
....*....|....*....|....*....|..
gi 2230564503 938 YSIVAEHGGQIDIESPPAgqtHGTRILLWLPL 969
Cdd:NF038348 545 HGIVEHHRGRIDVASEPG---RGSTFTITLPV 573
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
42-500 |
2.09e-24 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 107.98 E-value: 2.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 42 LALGVYA---SAWAIHGTLEQADRSGYGYLAYYLGAA-GAFLLAPMLLVPIQRMAHTyqlaSLADLFAFRFrSRWVGTLV 117
Cdd:COG0591 45 LALSLGAtwlSAWTFLGVPGLAYAYGLSALWYALGYAlGALLLALFFAPRLRRLGAL----TIPEFLEKRF-GRGLRLLA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 118 TLVSLLAVLPLLALQMQTLGNAIRLLSGSASqaWLAPGLSALIALFAILFGarhthlnarqdGLLAAI---ALESVVKLG 194
Cdd:COG0591 120 AIIILLFLLGYLAAQLVALGKLLEALFGIPY--WLGILIGALIVLLYTVLG-----------GLRAVAwtdVLQGILMLV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 195 AMLALGAVALFGIfDGPGDLQSWLDGPGHL-AQAETHPLAPAQWRTLLMLFFAAAFLMPHMFHITFAEPlGRRTLLRAAW 273
Cdd:COG0591 187 GLILLLIVALSAL-GGFGELFAALPAPGLLsLFPGLGFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAK-SEKEARKAAL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 274 VMPLFLLLMALPVPLI-----LWGAQRLGVDASLTGSAYLAFGLSSswWIGALTFIAGLAAASGTMIIISLALSGMILNH 348
Cdd:COG0591 265 IGGLLYLLFYLLAALIgllarALFPDLPLADPDLALPLLILELLPP--GLAGLLLAAILAAAMSTADSQLLAASSVFTRD 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 349 LVL-VAHPPIAQPDLYRWLRWLRRALIAAVIGGGWLFYRLVGvhhDLSSLAMASFVGMAqcLPGMLALLYWPGANRKGMV 427
Cdd:COG0591 343 IYKpFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPSSIL---DLVLLAWGGLGAAL--LPPLLLGLFWKRATKAGAL 417
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2230564503 428 TGLVVGVAIWLagLWPSLLGGAPWLPPIPPGlealadepdwylvtLVSLAANVLSFILVSLATRTSAGERAAA 500
Cdd:COG0591 418 AGMIAGLVVVL--LWKLLGGPLGPFGWLYPI--------------LPGLLVSLLVFVVVSLLTKPPSEEVLEE 474
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
759-971 |
9.22e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.08 E-value: 9.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 759 AHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVTGAAFQPVSMAEVTDEALHLIH 838
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEARE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 839 LARSGEDVVFENRCPATpRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFE 918
Cdd:PRK11100 344 AQAAAKGITLRLRPDDA-RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2230564503 919 PF-TTTKPAGE--GTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHR 971
Cdd:PRK11100 423 RFySLPRPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEG---GVLATLTLPRHF 475
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-956 |
1.89e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 95.60 E-value: 1.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDA--SAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEGTGLGLPLVYSIVA 942
Cdd:cd16976 1 IQQVLMNLLQNALDAmgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVE 80
|
90
....*....|....*
gi 2230564503 943 EHGGQIDI-ESPPAG 956
Cdd:cd16976 81 EHGGRLSVaNEEGAG 95
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
738-969 |
1.11e-22 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 100.54 E-value: 1.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 738 LEDELVHAARLASIGQLAAGVAHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVT 817
Cdd:PRK11073 117 LSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVT 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 818 GaafqpvSMAEVTDEALHLIHLaRSGEDVVFE-NRCPATPRVTGDAQRLQQVMINLLGNARDASAPGG-------RVIVA 889
Cdd:PRK11073 197 E------SIHKVAERVVQLVSL-ELPDNVRLIrDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPEGgtitlrtRTAFQ 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 890 AEPEGERLR----VTVTDEGHGIDERVRDHLFEPFTTTKPAgeGTGLGLPLVYSIVAEHGGQIDIESPPaGQTHGTrilL 965
Cdd:PRK11073 270 LTLHGERYRlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG--GTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFS---V 343
|
....
gi 2230564503 966 WLPL 969
Cdd:PRK11073 344 YLPI 347
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-968 |
2.32e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 89.90 E-value: 2.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDA--SAPGGRVIVAAEPEG---ERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAgeGTGLGLP 935
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAieGRPSDVGEVRIRVEAdqdGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK--GTGLGLA 78
|
90 100 110
....*....|....*....|....*....|...
gi 2230564503 936 LVYSIVAEHGGQIDIESPPAGqthGTRILLWLP 968
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAG---GACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-958 |
3.46e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 89.38 E-value: 3.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGR----VIVAAEPEGER-LRVTVTDEGHGIDERVRDHLFEPFTTTKPagEGTGLGLPLVYS 939
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICRS 78
|
90
....*....|....*....
gi 2230564503 940 IVAEHGGQIDIESPPAGQT 958
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGA 97
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
865-969 |
4.40e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 86.39 E-value: 4.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNA-----RdasapgGRVIVAA-----EPEGERLRVTVTDEGHGIDERVRDHLFEPFT-----TTKPAGeG 929
Cdd:cd16922 1 LRQILLNLLGNAikfteE------GEVTLRVsleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadssTTRKYG-G 73
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2230564503 930 TGLGLPLVYSIVAEHGGQIDIESPPaGQthGTRILLWLPL 969
Cdd:cd16922 74 TGLGLAISKKLVELMGGDISVESEP-GQ--GSTFTFTLPL 110
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
749-969 |
9.42e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 89.97 E-value: 9.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 749 ASIGQLA-------AGVAHEIGNPITGI-----------SSLAQNLRYDTDDpelreTADQIQQLTDRVsrivgslvgfa 810
Cdd:PRK09467 220 AGIKQLEddrtllmAGVSHDLRTPLTRIrlatemmseedGYLAESINKDIEE-----CNAIIEQFIDYL----------- 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 811 hggRHVTGAAFQPVSMAEVTDEALHlihlARSGEDVVFENRCPATP-RVTGDAQRLQQVMINLLGNArdASAPGGRVIVA 889
Cdd:PRK09467 284 ---RTGQEMPMEMADLNALLGEVIA----AESGYEREIETALQPGPiEVPMNPIAIKRALANLVVNA--ARYGNGWIKVS 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 890 AEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA--GEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWL 967
Cdd:PRK09467 355 SGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSArgSSGTGLGLAIVKRIVDQHNGKVELGNSEEG---GLSARAWL 431
|
..
gi 2230564503 968 PL 969
Cdd:PRK09467 432 PL 433
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
753-959 |
1.32e-17 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 86.67 E-value: 1.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 753 QLAAGVAHEIGNPITGISSLAQ-NLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVTGAAFQPVSMAEVTD 831
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELA 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 832 EALHLIHLARSGEDVVFENRCPAtpRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDER 911
Cdd:TIGR01386 323 KVAEYFEPLAEERGVRIRVEGEG--LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2230564503 912 VRDHLFEPFTTTKPA----GEGTGLGLPLVYSIVAEHGGQIDIESPPaGQTH 959
Cdd:TIGR01386 401 HLSRLFDRFYRVDPArsnsGEGTGLGLAIVRSIMEAHGGRASAESPD-GKTR 451
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
758-969 |
2.85e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 87.39 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 758 VAHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAH--GGrHVTgAAFQPVSMAEVTDEALH 835
Cdd:PRK15347 405 ISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRieSG-QMT-LSLEETALLPLLDQAML 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 836 LIHLARSGEDVVFenRCPATPRVTG----DAQRLQQVMINLLGNARDASaPGGRVIVAAEPEGERLRVTVTDEGHGIDER 911
Cdd:PRK15347 483 TIQGPAQSKSLTL--RTFVGAHVPLylhlDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQ 559
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2230564503 912 VRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLPL 969
Cdd:PRK15347 560 QQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPG---VGSCFSLVLPL 614
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-968 |
2.43e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 75.44 E-value: 2.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNA----RDASAPggRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTT--TKPAGEGTGLGLPLVY 938
Cdd:cd16921 1 LGQVLTNLLGNAikfrRPRRPP--RIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRlhSREEYEGTGVGLAIVR 78
|
90 100 110
....*....|....*....|....*....|
gi 2230564503 939 SIVAEHGGQIDIESPPAGqthGTRILLWLP 968
Cdd:cd16921 79 KIIERHGGRIWLESEPGE---GTTFYFTLP 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
871-968 |
5.61e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 74.63 E-value: 5.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 871 NLLGNARDASA----PGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEgTGLGLPLVYSIVAEHGG 946
Cdd:cd16915 7 NLIDNALDALAatgaPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGE-RGIGLALVRQSVERLGG 85
|
90 100
....*....|....*....|..
gi 2230564503 947 QIDIESPPAGqthGTRILLWLP 968
Cdd:cd16915 86 SITVESEPGG---GTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-968 |
1.51e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 73.38 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPG-GRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEG----TGLGLPLVYS 939
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAfgqhSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 2230564503 940 IVAEHGGQIDIES-PPAGQTHGTRILLWLP 968
Cdd:cd16953 81 IIEAHGGISVAENhNQPGQVIGARFTVQLP 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-958 |
2.03e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 73.20 E-value: 2.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAP-GGRVIVAAEPE------GER----LRVTVTDEGHGIDERVRDHLFEPFTTTKPagEGTGLG 933
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQrqvtlgHPRhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRE--NGTGLG 78
|
90 100
....*....|....*....|....*
gi 2230564503 934 LPLVYSIVAEHGGQIDIESPPaGQT 958
Cdd:cd16918 79 LAIAQNIVSQHGGVIECDSQP-GHT 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-956 |
4.38e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 72.11 E-value: 4.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEG---TGLGLPLV 937
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGqksTGLGLAFV 80
|
90
....*....|....*....
gi 2230564503 938 YSIVAEHGGQIDIESPPAG 956
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDG 99
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-968 |
6.75e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 71.73 E-value: 6.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPF----TTTKPAGEGTGLGLPL 936
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFyrveSSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|..
gi 2230564503 937 VYSIVAEHGGQIDIESPPAGqthGTRILLWLP 968
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLG---GLRLVLTLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
854-967 |
8.38e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 71.28 E-value: 8.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 854 ATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLrVTVTDEGHGIDERVRDHLFEPFTTTKP-AGEGTGL 932
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGqNYGGSGL 81
|
90 100 110
....*....|....*....|....*....|....*
gi 2230564503 933 GLPLVYSIVAEHGGQIDIESppaGQTHGTRILLWL 967
Cdd:cd16940 82 GLSIVKRIVELHGGQIFLGN---AQGGGLEAWVRL 113
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
753-968 |
2.12e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 75.77 E-value: 2.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 753 QLAAGVAHEIGNPITGIS-SLaqnlrydtddpELRETADQIQ-----QLTDRVSRIVGSLVGFAHGGRHVTGAAFQPVSM 826
Cdd:PRK10755 139 LFTADVAHELRTPLAGIRlHL-----------ELLEKQHHIDvapliARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 827 AE--VTDEALHLIHLARSGEDVVFENRCPATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDE 904
Cdd:PRK10755 208 LEdvILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDE 287
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2230564503 905 GHGIDERVRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPagQTHGTRILLWLP 968
Cdd:PRK10755 288 GPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQ--ERSGTRAWVWLP 349
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
853-973 |
2.57e-14 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 76.60 E-value: 2.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 853 PATPRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKP----AGE 928
Cdd:PRK10549 341 PDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGsrnrASG 420
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2230564503 929 GTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHRED 973
Cdd:PRK10549 421 GSGLGLAICLNIVEAHNGRIIAAHSPFG---GVSITVELPLERDL 462
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-968 |
3.03e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.40 E-value: 3.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASapGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA--GEGTGLGLPLVYSIVA 942
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNArgTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|....*.
gi 2230564503 943 EHGGQIDIESPPAGqthGTRILLWLP 968
Cdd:cd16950 79 AHGGSLTLANRAGG---GLCARIELP 101
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
746-970 |
4.21e-14 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 75.80 E-value: 4.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 746 ARLASIGQLAAGVAHEIGNPITgisslaqNLRY------DTDDPE---LRETADQIQQLTDRvsrivgsLVGFAHGGRHV 816
Cdd:PRK10604 207 ALIASKKQLIDGIAHELRTPLV-------RLRYrlemsdNLSAAEsqaLNRDIGQLEALIEE-------LLTYARLDRPQ 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 817 TGAAFQPVSMAEVTDEALHLIHLARsgEDVVFENRCPATPRV-TGDAQRLQQVMINLLGNARDASapGGRVIVAAEPEGE 895
Cdd:PRK10604 273 NELHLSEPDLPAWLSTHLADIQAVT--PEKTVRLDTPHQGDYgALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGN 348
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2230564503 896 RLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGE----GTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLH 970
Cdd:PRK10604 349 QACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELG---GARFSFSWPVW 424
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
734-954 |
9.30e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.22 E-value: 9.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 734 EMKwLEDELVH--------AARLASIGQLAAGVAHEIGNPITGiSSLA---QNLRYDTDDPELRETA-DQIQQLTDRVSR 801
Cdd:PRK09303 127 LLQ-LSDELFVlrqenetlLEQLKFKDRVLAMLAHDLRTPLTA-ASLAletLELGQIDEDTELKPALiEQLQDQARRQLE 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 802 IVGSLV-GFAHGGRHvTGAAF----QPVSMAEVTDEALHLIHLARSGEDVVFENRCPAT-PRVTGDAQRLQQVMINLLGN 875
Cdd:PRK09303 205 EIERLItDLLEVGRT-RWEALrfnpQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlPSVYADQERIRQVLLNLLDN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 876 ARDASAPGGRVIVAA-EPEGERLRVTVTDEGHGIDERVRDHLFE-----PFTTTKpagEGTGLGLPLVYSIVAEHGGQID 949
Cdd:PRK09303 284 AIKYTPEGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIFEdrvrlPRDEGT---EGYGIGLSVCRRIVRVHYGQIW 360
|
....*
gi 2230564503 950 IESPP 954
Cdd:PRK09303 361 VDSEP 365
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-969 |
5.30e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 65.81 E-value: 5.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASApgGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA----GEGTGLGLPLVYSI 940
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*....
gi 2230564503 941 VAEHGGQIDIESppaGQTHGTRILLWLPL 969
Cdd:cd16949 79 IEQHGGKIKASN---RKPGGLRVRIWLPA 104
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
756-980 |
7.08e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.02 E-value: 7.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 756 AGVAHEIGNPITGISSLAQNLrydTDDPELRETADQIQQLTDRVSRIVGSL-----VGFAHGGRHVTGAAFQPVSMAEVT 830
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLL---ADNPALNAQRDDLRAITDSGESLLTILndildYSAIEAGGKNVSVSDEPFEPRPLL 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 831 DEALHLIHLARSGEDVV----FENRCPATprVTGDAQRLQQVMINLLGNARDASAPGgRVIVAAEPEGERLRVTVTDEGH 906
Cdd:PRK11466 526 ESTLQLMSGRVKGRPIRlatdIADDLPTA--LMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGC 602
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2230564503 907 GIDERVRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLPLHREDAESTDEP 980
Cdd:PRK11466 603 GIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPE---VGSCFCLRLPLRVATAPVPKTV 673
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-969 |
1.94e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 64.37 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNA-RDASApggRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGE----GTGLGLPLVYS 939
Cdd:cd16939 1 MARALDNLLRNAlRYAHR---TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDratgGFGLGLAIVHR 77
|
90 100 110
....*....|....*....|....*....|
gi 2230564503 940 IVAEHGGQIDIESPPAGqthGTRILLWLPL 969
Cdd:cd16939 78 VALWHGGHVECDDSELG---GACFRLTWPR 104
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
856-970 |
2.59e-12 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 70.19 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 856 PRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA----GEGTG 931
Cdd:PRK09835 367 CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSrqrkGEGSG 446
|
90 100 110
....*....|....*....|....*....|....*....
gi 2230564503 932 LGLPLVYSIVAEHGGQIDIESPPagqtHGTRILLWLPLH 970
Cdd:PRK09835 447 IGLAIVKSIVVAHKGTVAVTSDA----RGTRFVISLPRL 481
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
823-954 |
4.59e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 70.26 E-value: 4.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 823 PVSMAEVTDEALHLihLARSGED------VVFENRCPatPRVTGDAQRLQQVMINLLGNA-----RdasapgGRVIVAAE 891
Cdd:PRK11107 365 PFSLRETLDEVVTL--LAHSAHEkgleltLNIDPDVP--DNVIGDPLRLQQIITNLVGNAikfteS------GNIDILVE 434
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2230564503 892 PEGER-----LRVTVTDEGHGIDERVRDHLFEPFT-----TTKPAGeGTGLGLPLVYSIVAEHGGQIDIESPP 954
Cdd:PRK11107 435 LRALSntkvqLEVQIRDTGIGISERQQSQLFQAFRqadasISRRHG-GTGLGLVITQKLVNEMGGDISFHSQP 506
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
861-956 |
6.49e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 63.28 E-value: 6.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAAEP-EGERLRVTVTDEGHGIDERVRDHLFEPF----TTTKPAGEGTGLGLP 935
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdGSSTRAHGGTGLGLS 80
|
90 100
....*....|....*....|.
gi 2230564503 936 LVYSIVAEHGGQIDIESPPAG 956
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGG 101
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
759-956 |
7.86e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 65.44 E-value: 7.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 759 AHEIGNPITGISSLAQNLRYDTDDPELRETA-DQIQQLTDRVSRIVGSLVGFAHGGRHVTGAAFQPVSMAEVTDEAL--H 835
Cdd:PRK10337 245 AHELRSPLAALKVQTEVAQLSDDDPQARKKAlLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVmdI 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 836 LIHLARSGEDVVFEnrCPATPRV-TGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEgerlRVTVTDEGHGIDERVRD 914
Cdd:PRK10337 325 YHTAQQAGIDVRLT--LNAHPVIrTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALA 398
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2230564503 915 HLFEPFTttKPAGE---GTGLGLPLVYSIVAEHGGQIDIESPPAG 956
Cdd:PRK10337 399 RIGERFY--RPPGQeatGSGLGLSIVRRIAKLHGMNVSFGNAPEG 441
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
459-974 |
1.51e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 64.93 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 459 LEALADEPDWYLVTLVSLAANVLSFILVSLATRTSAGERAAAEACSVDAVVRPMRLPLVAANGLEIKRHLSRALGQEVAE 538
Cdd:COG3920 8 LLLLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 539 REVERALAALQMSPLDGRPYALRRLRDRIQANLSGLMGPSVAQDIVDRFLPYRQDGPGATEDIHFVENRLEDYRPRLNGL 618
Cdd:COG3920 88 LLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEEL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 619 AREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPPWNELLGRILAEPASQLYKQP 698
Cdd:COG3920 168 AALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 699 VTLSGGQRFLSLHKAERQDERATHGGTVILVedhSEMKWLEDELVHAARLASIgqLAAGVAHEIGNPITGISSLAQNLRY 778
Cdd:COG3920 248 RGLGRLLLLLLLLLLLLRALLLLAAGIRLVI---TERKRAEEELEASLEEKEL--LLRELHHRVKNNLQVVSSLLRLQAR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 779 DTDDPELRETADQIQqltDRVSRIvgSLVgfaHGgRHVTGAAFQPVSMAEVTDEALHLIHLARSGEDVVFENRCPAtprV 858
Cdd:COG3920 323 RADDPEAREALEESQ---NRIQAL--ALV---HE-LLYQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---V 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 859 TGDAQRLQQV--MIN-LLGNA---RDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVrdhlfepftttkPAGEGTGL 932
Cdd:COG3920 391 ELPADAAVPLglILNeLVTNAlkhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV------------DPPARKGL 458
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2230564503 933 GLPLVYSIVAEHGGQIDIESPPagqthGTRILLWLPLHREDA 974
Cdd:COG3920 459 GLRLIRALVRQLGGTLELDRPE-----GTRVRITFPLAELAA 495
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
63-489 |
1.76e-10 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 64.45 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 63 SGYGYLAYYLGAAGAFLLAPMLLVPIQRMAHTYqlaSLADLFAFRFRSRWVGTLVTLVSLLAVLPLLALQMQTLGNAIRL 142
Cdd:cd11480 64 SGYDGLAYAIGWTGGYVLLLLLVAEPLRNFGKY---TVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 143 LSGsaSQAWLAPGLSALIALFAILFGarhthlnarqdGLLAAI---ALESVVKLGAML--ALGAVALFGIFDGPGDLQSW 217
Cdd:cd11480 141 LLG--IPYEVGVVVVGALMIVYVVLG-----------GMRATTwvqIIQYVLLLGAFLvpAILVLARFGGNPLGAGPGLL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 218 LDGPGHLAQAETHPLAPAQWRTLLMLFFAAAF-LM------PHMFHITFAEPLG---RRTLLRAAWVMPLF--------- 278
Cdd:cd11480 208 GLAAAAASGAGEAYLAPGLLLTDPLDVISLTLaLMlgtaglPHVLMRFYTVPDAraaRKSVVWALGFIGLFyllapalgf 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 279 ---LLLMALPVPLILWGAQRLGVD------ASLTGSAYLAFGLssswwIGALTFIAGLAAASGTMIIISLALSGMILNHL 349
Cdd:cd11480 288 garALVGPDVIGAPIAGELDGGGDmavlllPEIAGLGDLLLAL-----VAAGAFAAILATVAGLLLAAASALAHDLYAGV 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 350 VlvaHPPIAQpdlYRWLRWLRRALIAAVIGGGWL--FYRLVGVHHdLSSLAMAsfVGMAQCLPGMLALLYWPGANRKGMV 427
Cdd:cd11480 363 I---RPGASE---RREVRVARIAAVVVGVIAILLalLFPPQNVAF-LVALAFA--IAASAFFPVLVLGIFWRRFTTRGAI 433
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2230564503 428 TGLVVG--VAIWLAGLWPSLLG-----GAPWLPPIPPGlealadepdwylvtLVSLAANVLSFILVSLA 489
Cdd:cd11480 434 AGMLVGllVSLVLIVLSPAVSGappghDFAGFPLTNPG--------------LVSVPLGFLVAIVVSLL 488
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
745-969 |
2.09e-10 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 65.06 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 745 AARLASIGQ-----LAAGVAHEIGNPITGISSLAQNLRYD--TDDPELRETADQIQQLTDRVSRIVGSLVGFAH---GGR 814
Cdd:PRK10490 653 QARLASEREqlrnaLLAALSHDLRTPLTVLFGQAEILTLDlaSEGSPHARQASEIRQQVLNTTRLVNNLLDMARiqsGGF 732
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 815 HVTgAAFQpvSMAEVTDEALHLIHLARSGEDVVFEnrCPAT-PRVTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPE 893
Cdd:PRK10490 733 NLR-KEWL--TLEEVVGSALQMLEPGLSGHPINLS--LPEPlTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVE 807
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2230564503 894 GERLRVTVTDEGHGIDERVRDHLFEPFT--TTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPL 969
Cdd:PRK10490 808 GERLQLDVWDNGPGIPPGQEQLIFDKFArgNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEG---GACFRVTLPL 882
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
860-966 |
6.87e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 63.07 E-value: 6.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 860 GDAQRLQQVMINLLGNARDASAPGGrVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPF----TTTKPAGEGTGLGLP 935
Cdd:PRK10841 558 GDPMRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfqvgTGVQRNFQGTGLGLA 636
|
90 100 110
....*....|....*....|....*....|..
gi 2230564503 936 LVYSIVAEHGGQIDIESPPA-GQTHGTRILLW 966
Cdd:PRK10841 637 ICEKLINMMDGDISVDSEPGmGSQFTIRIPLY 668
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
748-810 |
1.12e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 55.30 E-value: 1.12e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2230564503 748 LASIGQLAAGVAHEIGNPITGISSLAQNL-RYDTDDPELRETADQIQQLTDRVSRIVGSLVGFA 810
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLeEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
871-972 |
1.71e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 61.47 E-value: 1.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 871 NLLGNARDASA--PGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKpaGEGTGLGLPLVYSIVAEHGGQI 948
Cdd:PRK11086 440 NLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTK--GSNRGVGLYLVKQSVENLGGSI 517
|
90 100
....*....|....*....|....
gi 2230564503 949 DIESPPAgqtHGTRILLWLPLHRE 972
Cdd:PRK11086 518 AVESEPG---VGTQFFVQIPWDGE 538
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
675-973 |
2.02e-09 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 61.39 E-value: 2.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 675 LPPPWNELLGRILAEpasqlykqpvTLSGGQRFLSLHKAERQDERATHGGTVILVedHSEMKWLEDELVHA--------- 745
Cdd:PRK15053 257 LSSPGRQWLGKPIAE----------VVRPADFFTEQIDEKRQDVVANFNGLSVIA--NREAIRSGDDLLGAiisfrskde 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 746 -----ARLASIGQLAAG---VAHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRivgslvgfAHGGRHVT 817
Cdd:PRK15053 325 istlnAQLTQIKQYVESlrtLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLRE--------AFADRQVA 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 818 GAAFQPVsmaevtdealhliHLARS-GEDVVFENRCPATPRVTG-DAQRLQQVMINLLGNARDAS---APGGRVI-VAAE 891
Cdd:PRK15053 397 GLLFGKV-------------QRARElGLKMVIVPGSQLSQLPPGlDSTEFAAIVGNLLDNAFEASlrsDEGNKIVeLFLS 463
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 892 PEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGEGT-GLGLPLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLP-L 969
Cdd:PRK15053 464 DEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGLYLIASYVTRCGGVITLEDNDP---CGTLFSIFIPkV 540
|
....
gi 2230564503 970 HRED 973
Cdd:PRK15053 541 KPND 544
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-966 |
2.12e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 55.93 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA---GEGTGLGLPLV 937
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSrrsGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*....
gi 2230564503 938 YSIVAEHGGQIDIESPPAGqthGTRILLW 966
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKG---GAEVTVK 106
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
750-810 |
2.77e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 54.14 E-value: 2.77e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2230564503 750 SIGQLAAGVAHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFA 810
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLS 61
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
731-983 |
4.60e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 60.34 E-value: 4.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 731 DHSEMKWLEDELVHAAR-----LASIgqlaagvAHEIGNPITGISSLAQNLRydtdDPELreTADQIQQL-TDRVS---- 800
Cdd:PRK11091 265 DITERKRYQDALEKASRdkttfISTI-------SHELRTPLNGIVGLSRILL----DTEL--TAEQRKYLkTIHVSaitl 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 801 -RIVGSLVGFAHGGRHVTGAAFQPVSMAEVTDEALHLIHL--ARSGEDVVFENRCPATPRVTGDAQRLQQVMINLLGNAR 877
Cdd:PRK11091 332 gNIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENLSGLqaEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAV 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 878 DASAPGGRVI-VAAEpEGERLRVTVTDEGHGIDERVRDHLF------EPFTTTKPAgEGTGLGLPLVYSIVAEHGGQIDI 950
Cdd:PRK11091 412 KFTQQGGVTVrVRYE-EGDMLTFEVEDSGIGIPEDELDKIFamyyqvKDSHGGKPA-TGTGIGLAVSKRLAQAMGGDITV 489
|
250 260 270
....*....|....*....|....*....|...
gi 2230564503 951 ESPPAgqtHGTRILLWLPLHREDAESTDEPDPD 983
Cdd:PRK11091 490 TSEEG---KGSCFTLTIHAPAVAEEVEDAFDED 519
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
885-972 |
6.50e-09 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 59.56 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 885 RVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGE----GTGLGLPLVYSIVAEHGGQIDIESPPAGqthG 960
Cdd:PRK09470 372 KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLG---G 448
|
90
....*....|..
gi 2230564503 961 TRILLWLPLHRE 972
Cdd:PRK09470 449 LRLTIWLPLYKR 460
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
750-806 |
1.51e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 52.18 E-value: 1.51e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 2230564503 750 SIGQLAAGVAHEIGNPITGISSLAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSL 806
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDL 57
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-952 |
1.74e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 53.16 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPA--GEGTGLGLPLVYSIVA 942
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSrnTEGAGLGLSIAKAIIE 80
|
90
....*....|
gi 2230564503 943 EHGGQIDIES 952
Cdd:cd16923 81 LHGGSASAEY 90
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
880-972 |
7.14e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 56.18 E-value: 7.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 880 SAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTkpaGEGTGLGLPLVYSIVAEH---GGQIDIESPPAg 956
Cdd:COG2972 356 KEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK---GEGRGIGLRNVRERLKLYygeEYGLEIESEPG- 431
|
90
....*....|....*.
gi 2230564503 957 qtHGTRILLWLPLHRE 972
Cdd:COG2972 432 --EGTTVTIRIPLEEE 445
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
860-958 |
1.03e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 51.75 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 860 GDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTK----PAGEGTGLGLP 935
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEdsrnSAKQGNGLGLT 95
|
90 100
....*....|....*....|...
gi 2230564503 936 LVYSIVAEHGGQIDIESPPAGQT 958
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKT 118
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
63-500 |
2.87e-07 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 54.39 E-value: 2.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 63 SGYGYLAYYLGAAGAFLLAPMLLVPIQRMAHTYqlaSLADLFAFRFRSRWVGTLVTLVSLLAVLPLLALQMQTLGNAIRL 142
Cdd:COG4147 78 SGYDGLIYSIGWLVGYVLLLLLLAEYLRNFGKF---TVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 143 LSGSaSQAWLAPGLSALIALFAILFGARHTHLNArqdgllaaiALESVVKLGAMLaLGAVALFGIFDG-PGDLQSWLDGP 221
Cdd:COG4147 155 LLGV-DYEVAVVIVGVLMIVYVVLGGMKGTTWVQ---------IIKAVLLIFAYT-VPAVLVLAQFGFnPLPLLAKAAEV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 222 GHLAQAETHPLAPaQWRTLLMLFFAAAFL-----MPHMFHITFAEPLG---RRTLLRAAWVMPLFLLL--------MALP 285
Cdd:COG4147 224 HDLGAAYLEPGGL-VKSPLDFISLGLALMlgtagLPHILMRFFTVPDAkeaRKSVGWALGFIGLFYLTapalgfgaRALV 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 286 VPLILWGAQRL------GVDASLTGSAYLAFGlsSSWWIG---ALTFIAGLAAASGTMIIISLALSGMILNHlVLVAHPP 356
Cdd:COG4147 303 GPLPEWFDTGLigaadgGGNMAVLALAEIAGG--GNWLLGlvaAGAFATILAVVAGLLLAIASAISHDLYAN-VIKGKAT 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 357 IAQPdlyrwLRWLRRALIAAVIGGGWL--FYRLVGVHHdLSSLAMAsfVGMAQCLPGMLALLYWPGANRKGMVTGLVVGV 434
Cdd:COG4147 380 EKEE-----LRVARIAAVVIGVVAILLgiNAPPQNVAF-LVALAFA--LAASANFPVLLLSIFWKRFNTRGAVAGMLVGL 451
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2230564503 435 AIWLAGLwpsLLGGAPWLPPIPPGLEALAdepdwyLVTLVSLAANVLSFILVSLATRTSAGERAAA 500
Cdd:COG4147 452 ISALVLI---VLSPFVWVLGVDAALFPLE------NPGLVSMPLGFLVAIVVSLLTPEPPAEDQEL 508
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
761-972 |
3.05e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 52.70 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 761 EIGNPITGISSLAQNLRY--DTDDPELRETADQIQQLTDRVSRIVGSLVgfahggRHVTGAAFQPVSMAEVTDEALHLIh 838
Cdd:COG4585 64 GVGQSLSAIKLQLEAARRllDADPEAAREELEEIRELAREALAELRRLV------RGLRPPALDDLGLAAALEELAERL- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 839 LARSGEDVVFEnrcpatprVTGDAQRL-QQVMINLLGNARDAS------APGGRVIVAAEPEGERLRVTVTDEGHGIDEr 911
Cdd:COG4585 137 LRAAGIRVELD--------VDGDPDRLpPEVELALYRIVQEALtnalkhAGATRVTVTLEVDDGELTLTVRDDGVGFDP- 207
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2230564503 912 vrdhlfepftttkPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAGqthGTRILLWLPLHRE 972
Cdd:COG4585 208 -------------EAAPGGGLGLRGMRERAEALGGTLTIGSAPGG---GTRVRATLPLAAA 252
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
861-952 |
2.36e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 47.28 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTK---PAGEGTGLGLPLV 937
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrNFQESTGMGLYLV 81
|
90
....*....|....*
gi 2230564503 938 YSIVAEHGGQIDIES 952
Cdd:cd16948 82 KKLCDKLGHKIDVES 96
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
882-968 |
5.86e-06 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 47.58 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 882 PGGRVIVAAEPEGERLRVTVTDEGHGID-ERVR-----------------------DHLFEP-FTTTKPAGE--GTGLGL 934
Cdd:cd16916 68 PEGTITLRAEHQGNQVVIEVSDDGRGIDrEKIRekaierglitadeaatlsddevlNLIFAPgFSTAEQVTDvsGRGVGM 147
|
90 100 110
....*....|....*....|....*....|....
gi 2230564503 935 PLVYSIVAEHGGQIDIESPPaGQthGTRILLWLP 968
Cdd:cd16916 148 DVVKRSIESLGGTIEVESEP-GQ--GTTFTIRLP 178
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
882-969 |
7.13e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 46.44 E-value: 7.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 882 PGGRVIVAAEPEGERLRVTVTDEGHGIDervRDHLFEPFTTTKPAgegtGLGLPLVYSIVAEhggqIDIESPPagqtHGT 961
Cdd:COG2172 55 PDGPVEVELELDPDGLEIEVRDEGPGFD---PEDLPDPYSTLAEG----GRGLFLIRRLMDE----VEYESDP----GGT 119
|
....*...
gi 2230564503 962 RILLWLPL 969
Cdd:COG2172 120 TVRLVKRL 127
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
72-494 |
7.32e-06 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 49.83 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 72 LGAAGAFLLAPMLLV-PIQRMahtyQLASLADLFAFRFrSRWVGTLVTLVSLLAVLPLLALQMQTLGNAIRLLSGSASqa 150
Cdd:cd11474 74 FGYALCLILGGLFFAkPMRRM----GLLTLGDFFRQRY-GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPV-- 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 151 WLAPGLSALIALFAILFGarhthlnarqdGLLAaIALESVVKLGAMLaLGAVALFG-IFDGPGDLQSwldgpGHLAQAET 229
Cdd:cd11474 147 ETGILISAAIVLAYTLFG-----------GMWS-VAYTDVVQLIVIF-VGLLVLVPfVLTNPGGVDI-----ASAAAAGK 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 230 HPLAPAQ-WRTLLMLFFAAAFLMphMF-----HITFAEPLGRRTLLRAAW----------VMPLFLLLMALPVPLILWG- 292
Cdd:cd11474 209 LRFFPWLgTKSDWLIWIDAWLTL--GLgsipqQDVFQRVLSAKSEKTAQRlsllagvgylLFAIPPLLIGLAAASIDPSl 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 293 -AQRLGVDASLTgsAYLAFGLSSSWWIGALTFIAGLAA----ASGTMiiisLALSGMILNHLVLVAHPPIAQPDlyRWLR 367
Cdd:cd11474 287 tQYGLEEDAQLI--LPLLLQYLTPLWVQVLFLGALLSAvmstADSAL----LAPSSVFSENIYKPPFRPKASDR--ELLW 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 368 WLRRALIAAVIGGGWLFYRLVGVHHdLSSLAmaSFVGMAQCLPGMLALLYWPGANRKGMVTGLVVGVAIWLAGLWPsllg 447
Cdd:cd11474 359 VMRISVVVFGAIATLMALTVESIYG-LVELA--SDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGEL---- 431
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 2230564503 448 gAPWLPPIPPglealadepdwylVTLVSLAANVLSFILVSLATRTSA 494
Cdd:cd11474 432 -LLGLPADIP-------------PQLQGFPFSTLAMVIGSLLPLAVS 464
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-968 |
7.72e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 45.66 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIV--AAEPEGERLrvTVTDEGHGIDERVRDHLFEPFTTTKPAGE----GTGLGLPLVY 938
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVrwSQEESGARL--SVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVK 78
|
90 100 110
....*....|....*....|....*....|
gi 2230564503 939 SIVAEHGGQIDIESPPAgqtHGTRILLWLP 968
Cdd:cd16952 79 HVMSRHDARLLIASELG---KGSRFTCLFP 105
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
884-969 |
2.04e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 48.25 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 884 GRVIVAAEPEGERLRVTVTDEGHGID-ERVRDH-----------------------LFEP-FTTTKPAGE--GTGLGLPL 936
Cdd:COG0643 309 GTITLSAYHEGGRVVIEVSDDGRGLDlEKIRAKaiekglitaeeaaalsdeellelIFAPgFSTAEEVTDlsGRGVGMDV 388
|
90 100 110
....*....|....*....|....*....|...
gi 2230564503 937 VYSIVAEHGGQIDIESPPaGQthGTRILLWLPL 969
Cdd:COG0643 389 VKTNIEALGGTIEIESEP-GK--GTTFTLRLPL 418
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
833-956 |
2.94e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 44.55 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 833 ALHLIHlARSGEDVVFEnrCPATPRVTGDAQRLQQVMINLLGNA-RDASapgGRVIVAAEPEGERLRVTVTDEGHGIDER 911
Cdd:cd16954 9 ALNKVY-QRKGVSISLD--ISPELRFPGERNDLMELLGNLLDNAcKWCL---EFVEVTARQTDGGLHLIVDDDGPGVPES 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2230564503 912 VRDHLFEPFTTTKPAGEGTGLGLPLVYSIVAEHGGQIDIESPPAG 956
Cdd:cd16954 83 QRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLG 127
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
861-969 |
7.87e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 46.65 E-value: 7.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 861 DAQRLQQVMINLLGNARDASAPGGRVIVAA----EPEGERLRVTVTDEGHGIDERVRDHLFEPFTTTKPAGE--GTGLGL 934
Cdd:PRK09959 825 DPQAFKQVLSNLLSNALKFTTEGAVKITTSlghiDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGL 904
|
90 100 110
....*....|....*....|....*....|....*
gi 2230564503 935 PLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLPL 969
Cdd:PRK09959 905 MICKELIKNMQGDLSLESHPG---IGTTFTITIPV 936
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
882-965 |
2.19e-04 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 42.14 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 882 PGGRVIVAAEPEGERLRVTVTDEGHGID--ERVRdhlfEPFTTTKPAGEGTGLGlplvYSIVAEHGGQIDIESPPagqTH 959
Cdd:cd16942 59 PNGIVSISVIIEDGVVHLTVRDEGVGIPdiEEAR----QPLFTTKPELERSGMG----FTIMENFMDEVIVESEV---NK 127
|
....*.
gi 2230564503 960 GTRILL 965
Cdd:cd16942 128 GTTVYL 133
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
865-968 |
4.38e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 40.51 E-value: 4.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 865 LQQVMINLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDhlfepfTTTKPAGEGTGLGLPLVYSIVAEH 944
Cdd:cd16924 6 LQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLN------ILGKKPKEGNGIGLYNVHQRLILL 79
|
90 100
....*....|....*....|....*..
gi 2230564503 945 GGQ---IDIESPPagqTHGTRILLWLP 968
Cdd:cd16924 80 FGEdygIHIASEP---DKGTRITFTIP 103
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
633-731 |
5.11e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 40.48 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 633 LTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAH-RDTLPPPWNE----LLGRILAEPASQLYKQPVTLSGGQRF 707
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTlAELLPPEDAArlerALRRALEGEEPIDFLEELLLNGEERH 80
|
90 100
....*....|....*....|....
gi 2230564503 708 LSLHKAERQDERATHGGTVILVED 731
Cdd:pfam08448 81 YELRLTPLRDPDGEVIGVLVISRD 104
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
879-958 |
7.30e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.56 E-value: 7.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 879 ASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERvrdhlfEPFTTTKPAGEGtGLGLPLVYSIVAEHGgqidIESPPAGQT 958
Cdd:cd16936 18 RHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPL------RPADPDAGLREG-GRGLALIRALMDEVG----YRRTPGGKT 86
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
857-968 |
7.72e-04 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 43.08 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 857 RVTGDAQRLQQVMINLLGNARDASAPGGRVIVA--AEPEGERLrvTVTDEGHGIDERVRDHLFEPFTTTKPAGE----GT 930
Cdd:PRK11006 310 KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwqRVPQGAEF--SVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGS 387
|
90 100 110
....*....|....*....|....*....|....*...
gi 2230564503 931 GLGLPLVYSIVAEHGGQIDIESPPAgqtHGTRILLWLP 968
Cdd:PRK11006 388 GLGLAIVKHALSHHDSRLEIESEVG---KGTRFSFVLP 422
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
867-934 |
8.02e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 39.72 E-value: 8.02e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2230564503 867 QVMI-NLLGNARDASAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEpftTTKPAGEGTGLGL 934
Cdd:cd16957 7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGK---TTVTSEKGTGTAL 72
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
47-433 |
2.59e-03 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 41.52 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 47 YASAWAIHGTLEQADRSGYGYLAYYLGAAGAFLLAPMLLVPIQRMAHTYqlaSLADLFAFRFRSR---WVGTLVTLVSLl 123
Cdd:TIGR00813 18 YISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAY---TMPEYLEKRFGKRilrGLSVLSLILYI- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 124 avlpllalqmqTLGNAIRLLSGSASQAwLAPGLSALIALFA-ILFGARHTHLnarqdGLLAAIALESVVKLGAMLALGAV 202
Cdd:TIGR00813 94 -----------FLYMSVDLFSGALLIE-LITGLDLYLSLLLlGAITILYTVF-----GGLKAVVWTDTIQAVIMILGTFI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 203 ALFGIFDGPGDLQSWLDgpghlaQAETHPLAPAQwRTLLMLFF-----------AAAFLMPHMFHITFAEPL-------- 263
Cdd:TIGR00813 157 LPVFAFSEVGGLGTFVE------KASQAAPTNPS-PDDLYDFFrdpstsdlpwgAGVFGLPHVALWYWTNQVivqrclaa 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 264 -----GRRTLLRAAWVMPLFLLLMALP--VPLILWGAQRLGVDASLTGSAYLAFGLSSSW----WIGALTFIAGLAAASG 332
Cdd:TIGR00813 230 ksakhAKKGCLISGVLKLLPMFGAVLPglIARALYTDIDPALAGAVNQNSDQAYPLLVQElmppGLAGLFLAAILAAVMS 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 333 TMIIISLALSGMILNHLVLVAHPPIAQPD--LYRWLRWLrrALIAAVIGGGWLFYRLVGVhHDLSSLAMASFVGMAqcLP 410
Cdd:TIGR00813 310 TLSSQLNSASTVFTMDLYKKIIRPNASGEkkIVMRGRIA--VLVAAVIAGFVAAAQGGQV-LQYVQEAFGGLGAPF--LP 384
|
410 420
....*....|....*....|...
gi 2230564503 411 GMLALLYWPGANRKGMVTGLVVG 433
Cdd:TIGR00813 385 VFLLGIFWKRMNAKGALAGMIAG 407
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
880-941 |
3.49e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.42 E-value: 3.49e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2230564503 880 SAPGGRVIVAAEPEGERLRVTVTDEGHGIDERVRDHlfEPFTTTKPAGEGTGLGLPLVYSIV 941
Cdd:pfam13581 50 EGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP--PDLEEPDEDRKEGGRGLALIRGLM 109
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
619-817 |
3.90e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.39 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 619 AREIDGLRRYHRRTLTRLPVGLCAFGEDGELLMWNDALAGLSGIPGESVIGAHRDTLPPP------WNELLGRILAEPAS 692
Cdd:COG2202 3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPedddefLELLRAALAGGGVW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 693 QLYKQPVTLSGGQRFLSLHKAERQDERATHGGTVILVEDHSEMKWLEDELVHAARLASIGQLAAGVAHEIGNP------- 765
Cdd:COG2202 83 RGELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLdgrilyv 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2230564503 766 ------ITGISS---LAQNLRYDTDDPELRETADQIQQLTDRVSRIVGSLVGFAHGGRHVT 817
Cdd:COG2202 163 npaaeeLLGYSPeelLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWV 223
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
856-963 |
4.50e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 40.77 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 856 PRVT--GDAQRLQQVMINLLGNARDASAPggRVIVAAEPEGERLRVTVTDEGHGIDERVRDHLFEPFT---TTKPageGT 930
Cdd:PRK10815 368 PEITfvGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQradTLRP---GQ 442
|
90 100 110
....*....|....*....|....*....|...
gi 2230564503 931 GLGLPLVYSIVAEHGGQIDIESPPAGqthGTRI 963
Cdd:PRK10815 443 GLGLSVAREITEQYEGKISAGDSPLG---GARM 472
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
848-968 |
4.84e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 38.17 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 848 FENRCPATPRVTGD--------AQRLQQVMINLLGNARD---ASAPGGRVIVAAEPEGERLRVTVTDEGHGIDErvrdhl 916
Cdd:cd16951 15 IHAVGDIRINITGDtgpvssevATAIGLVVNELLQNALKhafSDREGGTITIRSVVDGDYLRITVIDDGVGLPQ------ 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2230564503 917 fepftTTKPAGEGTgLGLPLVYSIV-AEHGGQIDIESppagQTHGTRILLWLP 968
Cdd:cd16951 89 -----DEDWPNKGS-LGLQIVRSLVeGELKAFLEVQS----AENGTRVNIDIP 131
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
858-965 |
5.73e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 38.21 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 858 VTGDAQRLQQVMINLLGNARDASAPGGRVIVAAEPEGE-----------------------RLRVTVTDEGHGIDERV-- 912
Cdd:cd16938 5 VVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGsedrsdrdwgpwrpsmsdesveiRFEVEINDSGSPSIESAsm 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2230564503 913 ------RDHLfepftttkpAGEGTGLGLPLVYSIVAEHGGQIDIeSPPAGQTHGTRILL 965
Cdd:cd16938 85 rnslnrRYNL---------SELGEHLSFSICKQLVQLMGGNIWI-VPGSGLGTTMSLLL 133
|
|
| MnhB |
COG2111 |
Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; |
72-486 |
6.22e-03 |
|
Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism];
Pssm-ID: 441714 [Multi-domain] Cd Length: 750 Bit Score: 40.46 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 72 LGAAGAFLLAPMLLVPIQRMAHTYQLASLADLFAFRFRSRWVGTLVTLVSLLAVLPLLALQMQTLGNAIRLLSGSASQAW 151
Cdd:COG2111 216 AAAALLFFLFLAAAAAAAAAAAALAAAAAAAVAVVALLLLLALVAGLLLLLLLLLLLLLLLLLLLGLLGALLLLLLLLLL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 152 LAPGLSALIALFAILFGARHTHLNARQDGLLAAIALESVVKLGAMLALGAVALFGIFDGPGDLQSWLDGPGHLAQAETHP 231
Cdd:COG2111 296 LLLLLLLLLLLLLLLLLGLLLAAAAAAAAALLALLLLLALALLLLLALALAAGLGLRLLLLLLLRLLAALLAAAAAAALA 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 232 LAPAQWRTLLMLFFAAAFLMPHMFHITFAEPLGRRTLLRAAWVMPLFLLLMALPVPLILWGAQRLGVDASLTGSAYLAFG 311
Cdd:COG2111 376 AAAALLLLLLLLLLALLLALGLLGLLLLLAALLAAAALLAAAAAAALALALLGGALAAAPAAAAAALLLLLLLLLALLLL 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 312 LSSSWWIGALTFIAGLAAASGTMIIISLALSGMILNHLVLVAHPPIAQPDLYRWLRWLRRALIAAVIGGGWLFYRLVGVH 391
Cdd:COG2111 456 ALLLLLLLLLALLLLLLLAVAALVALLLLLLLLLLLLLVLVLLLLLLLLLLLLLLLLLLLLRAAARAALLALAAAAAGAA 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2230564503 392 HDLSSLAMASFVGMAQCLPGMLALLYWPGANRKGMVTGLVVGVAIWLAGLWPSLLGGAPWLPPIPPGLEALADEPDWYLV 471
Cdd:COG2111 536 AYALALGLLLVAAASTTGGGGGGLLLGLLGVVVVVVVLVLVLLLLALGLVLLLLLARLGALALLLLLLLALLVAAAAASL 615
|
410
....*....|....*
gi 2230564503 472 TLVSLAANVLSFILV 486
Cdd:COG2111 616 ILSRLTRVLLPGILG 630
|
|
| |
