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Conserved domains on  [gi|2248611509|ref|WP_250614149|]
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secondary thiamine-phosphate synthase enzyme YjbQ [Bacillus subtilis]

Protein Classification

YjbQ family protein( domain architecture ID 2401)

YjbQ family protein may have thiamin phosphate synthase activity

CATH:  2.60.120.460
PubMed:  18178222
SCOP:  4002602

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0047 super family cl00439
Uncharacterized protein family UPF0047; This family has no known function. The alignment ...
 16-89 8.11e-43

Uncharacterized protein family UPF0047; This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.


The actual alignment was detected with superfamily member TIGR00149:

Pssm-ID: 469771  Cd Length: 132  Bit Score: 135.66  E-value: 8.11e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2248611509  16 SDMLRRFDEVYPWEHELDR-HMEGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDGPRTRTCYIKMMG 89
Cdd:TIGR00149  57 HDIERFFERLVPDDGNYEHdEGDDNMDAHIKSSLLGTSQHVPVENGRLQLGTWQGIFFAEFDGPRTRRIIVKVQG 131
 
Name Accession Description Interval E-value
TIGR00149_YjbQ TIGR00149
secondary thiamine-phosphate synthase enzyme; Members of this protein family have been studied ...
 16-89 8.11e-43

secondary thiamine-phosphate synthase enzyme; Members of this protein family have been studied extensively by crystallography. Members from several different species have been shown to have sufficient thiamin phosphate synthase activity (EC 2.5.1.3) to complement thiE mutants. However, it is presumed that this is a secondary activity, and the primary function of this enzyme remains unknown. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129253  Cd Length: 132  Bit Score: 135.66  E-value: 8.11e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2248611509  16 SDMLRRFDEVYPWEHELDR-HMEGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDGPRTRTCYIKMMG 89
Cdd:TIGR00149  57 HDIERFFERLVPDDGNYEHdEGDDNMDAHIKSSLLGTSQHVPVENGRLQLGTWQGIFFAEFDGPRTRRIIVKVQG 131
UPF0047 pfam01894
Uncharacterized protein family UPF0047; This family has no known function. The alignment ...
 15-87 9.05e-35

Uncharacterized protein family UPF0047; This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.


Pssm-ID: 460376  Cd Length: 116  Bit Score: 114.42  E-value: 9.05e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2248611509  15 QSDMLRRFDEVYPWEHElDRHM---EGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDGPRTRTCYIKM 87
Cdd:pfam01894  42 RRDLEAFLERLVPEDDP-YRHNdegPDNMPAHLKASLLGPSLTIPVTDGRLALGTWQGIYLCEFDGPRTRRVVVTI 116
YjbQ COG0432
Thiamin phosphate synthase YjbQ, UPF0047 family [Coenzyme transport and metabolism];
15-88 3.60e-33

Thiamin phosphate synthase YjbQ, UPF0047 family [Coenzyme transport and metabolism];


Pssm-ID: 440201  Cd Length: 133  Bit Score: 110.93  E-value: 3.60e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2248611509  15 QSDMLRRFDEVYPWEHELdRHM---EGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDG-PRTRTCYIKMM 88
Cdd:COG0432    57 RRDLEAFLERLVPEDDPY-RHNlegPDNMPAHLKASLLGSSLTIPVTDGRLALGTWQGIYLCEFDGrPRRRRVVVTVI 133
 
Name Accession Description Interval E-value
TIGR00149_YjbQ TIGR00149
secondary thiamine-phosphate synthase enzyme; Members of this protein family have been studied ...
 16-89 8.11e-43

secondary thiamine-phosphate synthase enzyme; Members of this protein family have been studied extensively by crystallography. Members from several different species have been shown to have sufficient thiamin phosphate synthase activity (EC 2.5.1.3) to complement thiE mutants. However, it is presumed that this is a secondary activity, and the primary function of this enzyme remains unknown. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129253  Cd Length: 132  Bit Score: 135.66  E-value: 8.11e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2248611509  16 SDMLRRFDEVYPWEHELDR-HMEGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDGPRTRTCYIKMMG 89
Cdd:TIGR00149  57 HDIERFFERLVPDDGNYEHdEGDDNMDAHIKSSLLGTSQHVPVENGRLQLGTWQGIFFAEFDGPRTRRIIVKVQG 131
UPF0047 pfam01894
Uncharacterized protein family UPF0047; This family has no known function. The alignment ...
 15-87 9.05e-35

Uncharacterized protein family UPF0047; This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.


Pssm-ID: 460376  Cd Length: 116  Bit Score: 114.42  E-value: 9.05e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2248611509  15 QSDMLRRFDEVYPWEHElDRHM---EGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDGPRTRTCYIKM 87
Cdd:pfam01894  42 RRDLEAFLERLVPEDDP-YRHNdegPDNMPAHLKASLLGPSLTIPVTDGRLALGTWQGIYLCEFDGPRTRRVVVTI 116
YjbQ COG0432
Thiamin phosphate synthase YjbQ, UPF0047 family [Coenzyme transport and metabolism];
15-88 3.60e-33

Thiamin phosphate synthase YjbQ, UPF0047 family [Coenzyme transport and metabolism];


Pssm-ID: 440201  Cd Length: 133  Bit Score: 110.93  E-value: 3.60e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2248611509  15 QSDMLRRFDEVYPWEHELdRHM---EGNTAAHMKSSTVGASQHVIVENGRLILGTWQGIYFCEFDG-PRTRTCYIKMM 88
Cdd:COG0432    57 RRDLEAFLERLVPEDDPY-RHNlegPDNMPAHLKASLLGSSLTIPVTDGRLALGTWQGIYLCEFDGrPRRRRVVVTVI 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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