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Conserved domains on  [gi|2279599020|ref|WP_256289211|]
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type II methionyl aminopeptidase [Halobellus inordinatus]

Protein Classification

M24 family metallopeptidase( domain architecture ID 320)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP_MetAP super family cl00279
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 13-296 4.01e-120

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


The actual alignment was detected with superfamily member cd01088:

Pssm-ID: 469704 [Multi-domain]  Cd Length: 291  Bit Score: 346.16  E-value: 4.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  13 KYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEASHATPGRDDETEF-DDGMVCLDCG 91
Cdd:cd01088     3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLkEGDVVKLDFG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  92 VHVDGYIADAAVTVDLSGN-PELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLSGHGVAQWDAHTGP 170
Cdd:cd01088    83 AHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAGK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 171 TIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDRSVRNRSARKVLEQVKEEYRTLPFAARWLD---E 247
Cdd:cd01088   163 SIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDrlgE 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2279599020 248 PRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:cd01088   243 TKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
 
Name Accession Description Interval E-value
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 13-296 4.01e-120

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 346.16  E-value: 4.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  13 KYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEASHATPGRDDETEF-DDGMVCLDCG 91
Cdd:cd01088     3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLkEGDVVKLDFG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  92 VHVDGYIADAAVTVDLSGN-PELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLSGHGVAQWDAHTGP 170
Cdd:cd01088    83 AHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAGK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 171 TIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDRSVRNRSARKVLEQVKEEYRTLPFAARWLD---E 247
Cdd:cd01088   163 SIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDrlgE 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2279599020 248 PRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:cd01088   243 TKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 7-295 4.10e-97

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 287.84  E-value: 4.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   7 DEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEASHATPGRDDETEFDDG-M 85
Cdd:TIGR00501   1 DIERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEPAFPCNISINECAAHFTPKAGDKTVFKDGdV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  86 VCLDCGVHVDGYIADAAVTVDLSGNP-ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLSGHGVAQW 164
Cdd:TIGR00501  81 VKLDLGAHVDGYIADTAITVDLGDQYdNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMAPY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 165 DAHTGPTIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDRSVRNRSARKVLEQVKEEYRTLPFAARW 244
Cdd:TIGR00501 161 RLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAERPVRLDSARNLLKTIDENYGTLPFARRW 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2279599020 245 LDE---PRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLT 295
Cdd:TIGR00501 241 LDKlgdEKYLFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEVTT 294
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 6-286 1.93e-45

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 159.49  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   6 LDEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEEL--ADGC----AFPVNISIDEEASHATPGRDDET 79
Cdd:PTZ00053  153 LSEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICERIESKSRELieADGLkcgwAFPTGCSLNHCAAHYTPNTGDKT 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  80 EFDDGMVC-LDCGVHVDGYIADAAVTVDLsgNPE---LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGY-----GY 150
Cdd:PTZ00053  233 VLTYDDVCkLDFGTHVNGRIIDCAFTVAF--NPKydpLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYeveikGK 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 151 T----PVLNLSGHGVAQWDAHTGPTIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDR---SVRNRS 223
Cdd:PTZ00053  311 TypikSIRNLNGHSIGPYIIHGGKSVPIVKGGENTRMEEGELFAIETFASTGRGYVNEDLECSHYMKDPGAefvPLRLPK 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2279599020 224 ARKVLEQVKEEYRTLPFAARWLD---EPRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVV 286
Cdd:PTZ00053  391 AKQLLKHINTNFGTLAFCRRWLDrlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILL 456
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-296 4.84e-32

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 118.95  E-value: 4.84e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   7 DEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELadGC--------AFP--VNISIDEEASHATPGrd 76
Cdd:COG0024     5 TPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH--GAipaflgyyGFPksICTSVNEVVVHGIPS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  77 dETEFDDG-MVCLDCGVHVDGYIADAAVTVdLSGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGY 150
Cdd:COG0024    81 -DRVLKDGdIVNIDVGAILDGYHGDSARTF-VVGEVspearRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 151 TPVLNLSGHGVAQwDAHTGPTIPNRGT-DRGVELEVGDVVAIEPFATTGRGKVTEgskeeiyslERDrsvrnrsarkvle 229
Cdd:COG0024   159 SVVREFVGHGIGR-EMHEEPQVPNYGRpGRGPRLKPGMVLAIEPMINAGTPEVKV---------LDD------------- 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2279599020 230 qvkeeyrtlpfaaRWLdepraemAITRleqqgvlhgypvlkedDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:COG0024   216 -------------GWT-------VVTK----------------DGSLSAQFEHTVAVTEDGPEILTL 246
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 12-193 1.76e-22

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 92.69  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  12 AKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEA--RIEELADGCAFPVNISIDEEAS--HATPgrdDETEFDDG-MV 86
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAarLRRGGARGPAFPPIVASGPNAAipHYIP---NDRVLKPGdLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  87 CLDCGVHVD-GYIADAAVTVdLSGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGY-TPVLNLSGH 159
Cdd:pfam00557  78 LIDVGAEYDgGYCSDITRTF-VVGKPspeqrELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2279599020 160 GVAQwDAHTGPTIPNRGTDRgvELEVGDVVAIEP 193
Cdd:pfam00557 157 GIGL-EVHEGPYISRGGDDR--VLEPGMVFTIEP 187
 
Name Accession Description Interval E-value
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 13-296 4.01e-120

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 346.16  E-value: 4.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  13 KYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEASHATPGRDDETEF-DDGMVCLDCG 91
Cdd:cd01088     3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAFPVNLSINECAAHYTPNAGDDTVLkEGDVVKLDFG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  92 VHVDGYIADAAVTVDLSGN-PELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLSGHGVAQWDAHTGP 170
Cdd:cd01088    83 AHVDGYIADSAFTVDFDPKyDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSIERYRLHAGK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 171 TIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDRSVRNRSARKVLEQVKEEYRTLPFAARWLD---E 247
Cdd:cd01088   163 SIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRDKPLRLPRARKLLDVIYENFGTLPFARRWLDrlgE 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2279599020 248 PRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:cd01088   243 TKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 7-295 4.10e-97

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 287.84  E-value: 4.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   7 DEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEASHATPGRDDETEFDDG-M 85
Cdd:TIGR00501   1 DIERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEPAFPCNISINECAAHFTPKAGDKTVFKDGdV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  86 VCLDCGVHVDGYIADAAVTVDLSGNP-ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLSGHGVAQW 164
Cdd:TIGR00501  81 VKLDLGAHVDGYIADTAITVDLGDQYdNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPISNLTGHSMAPY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 165 DAHTGPTIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDRSVRNRSARKVLEQVKEEYRTLPFAARW 244
Cdd:TIGR00501 161 RLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAERPVRLDSARNLLKTIDENYGTLPFARRW 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2279599020 245 LDE---PRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLT 295
Cdd:TIGR00501 241 LDKlgdEKYLFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEVTT 294
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 6-286 1.93e-45

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 159.49  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   6 LDEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEEL--ADGC----AFPVNISIDEEASHATPGRDDET 79
Cdd:PTZ00053  153 LSEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICERIESKSRELieADGLkcgwAFPTGCSLNHCAAHYTPNTGDKT 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  80 EFDDGMVC-LDCGVHVDGYIADAAVTVDLsgNPE---LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGY-----GY 150
Cdd:PTZ00053  233 VLTYDDVCkLDFGTHVNGRIIDCAFTVAF--NPKydpLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYeveikGK 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 151 T----PVLNLSGHGVAQWDAHTGPTIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTEGSKEEIYSLERDR---SVRNRS 223
Cdd:PTZ00053  311 TypikSIRNLNGHSIGPYIIHGGKSVPIVKGGENTRMEEGELFAIETFASTGRGYVNEDLECSHYMKDPGAefvPLRLPK 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2279599020 224 ARKVLEQVKEEYRTLPFAARWLD---EPRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVV 286
Cdd:PTZ00053  391 AKQLLKHINTNFGTLAFCRRWLDrlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILL 456
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 11-295 4.21e-34

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 124.14  E-value: 4.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  11 LAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCA------FP--VNISIDEEASHATPgrdDETEFD 82
Cdd:cd01086     1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAplgyygFPksICTSVNEVVCHGIP---DDRVLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  83 DG-MVCLDCGVHVDGYIADAAVTVDLSGNPE----LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLS 157
Cdd:cd01086    78 DGdIVNIDVGVELDGYHGDSARTFIVGEVSEeakkLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 158 GHGVAQwDAHTGPTIPNRGT-DRGVELEVGDVVAIEPFATTGrgkvtegskeeiyslerdrsvrnrsarkvleqvKEEYR 236
Cdd:cd01086   158 GHGIGR-KFHEEPQIPNYGRpGTGPKLKPGMVFTIEPMINLG---------------------------------TYEVV 203

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2279599020 237 TLPfaARWldepraeMAITRleqqgvlhgypvlkedDGELVSQAEHTVVVTEDGYENLT 295
Cdd:cd01086   204 TLP--DGW-------TVVTK----------------DGSLSAQFEHTVLITEDGPEILT 237
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 9-295 4.71e-32

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 122.30  E-value: 4.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   9 ETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEE-----------LADGCAFPVNISIDEEASHATPGRDD 77
Cdd:TIGR00495  18 EVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEetakifkkekeMEKGIAFPTCISVNNCVGHFSPLKSD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  78 ETE-FDDG-MVCLDCGVHVDGYIADAAVTVDLSGNPE---------LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIR 146
Cdd:TIGR00495  98 QDYiLKEGdVVKIDLGCHIDGFIALVAHTFVVGVAQEepvtgrkadVIAAAHLAAEAALRLVKPGNTNTQVTEAINKVAH 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 147 GYGYTPVLNLSGHGVAQW--DAH----TGPTIPNRGTDRGVELEVGDVVAIEPFATTGRGKVTE-GSKEEIYslERDRSV 219
Cdd:TIGR00495 178 SYGCTPVEGMLSHQLKQHviDGEkviiSNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAKDaDQRTTIY--KRDPSK 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 220 ----RNRSARKVLEQVKEEYRTLPFAARWLD-EPRAEMAITRLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENL 294
Cdd:TIGR00495 256 tyglKMKASRAFFSEIERRFDAMPFTLRNFEdEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQFKFTVLLMPNGPMRI 335


                  .
gi 2279599020 295 T 295
Cdd:TIGR00495 336 T 336
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-296 4.84e-32

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 118.95  E-value: 4.84e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   7 DEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELadGC--------AFP--VNISIDEEASHATPGrd 76
Cdd:COG0024     5 TPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH--GAipaflgyyGFPksICTSVNEVVVHGIPS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  77 dETEFDDG-MVCLDCGVHVDGYIADAAVTVdLSGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGY 150
Cdd:COG0024    81 -DRVLKDGdIVNIDVGAILDGYHGDSARTF-VVGEVspearRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 151 TPVLNLSGHGVAQwDAHTGPTIPNRGT-DRGVELEVGDVVAIEPFATTGRGKVTEgskeeiyslERDrsvrnrsarkvle 229
Cdd:COG0024   159 SVVREFVGHGIGR-EMHEEPQVPNYGRpGRGPRLKPGMVLAIEPMINAGTPEVKV---------LDD------------- 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2279599020 230 qvkeeyrtlpfaaRWLdepraemAITRleqqgvlhgypvlkedDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:COG0024   216 -------------GWT-------VVTK----------------DGSLSAQFEHTVAVTEDGPEILTL 246
PRK05716 PRK05716
methionine aminopeptidase; Validated
 8-295 1.88e-26

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 104.06  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   8 EETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCA------FP--VNISIDEEASHATPgrdDET 79
Cdd:PRK05716    8 PEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAplgyhgFPksICTSVNEVVCHGIP---SDK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  80 EFDDG-MVCLDCGVHVDGYIADAAVTVdLSGNPE-----LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPV 153
Cdd:PRK05716   85 VLKEGdIVNIDVTVIKDGYHGDTSRTF-GVGEISpedkrLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 154 LNLSGHGVAQwDAHTGPTIPNRGT-DRGVELEVGDVVAIEPFATTGRGKVTEGSKEeiyslerdrsvrnrsarkvleqvk 232
Cdd:PRK05716  164 REYCGHGIGR-KFHEEPQIPHYGApGDGPVLKEGMVFTIEPMINAGKREVKTLKDG------------------------ 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2279599020 233 eeyrtlpfaarWLdepraemAITRleqqgvlhgypvlkedDGELVSQAEHTVVVTEDGYENLT 295
Cdd:PRK05716  219 -----------WT-------VVTK----------------DGSLSAQYEHTVAVTEDGPEILT 247
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 8-295 5.87e-25

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 100.30  E-value: 5.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   8 EETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELA-----DGC-AFP--VNISIDEEASHATPgrdDET 79
Cdd:PRK12896   13 PRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGaipspEGYyGFPgsTCISVNEEVAHGIP---GPR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  80 EFDDG-MVCLDCGVHVDGYIADAAVTVDL-SGNPE---LVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVL 154
Cdd:PRK12896   90 VIKDGdLVNIDVSAYLDGYHGDTGITFAVgPVSEEaekLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSVVR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 155 NLSGHGVAQwDAHTGPTIPNRGTDR--GVELEVGDVVAIEPFattgrgkVTEGSKeeiyslerdrsvrnrsarkvleqvk 232
Cdd:PRK12896  170 DLTGHGVGR-SLHEEPSVILTYTDPlpNRLLRPGMTLAVEPF-------LNLGAK------------------------- 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2279599020 233 eEYRTLpfAARWldepraemaitrleqqgvlhgypVLKEDDGELVSQAEHTVVVTEDGYENLT 295
Cdd:PRK12896  217 -DAETL--DDGW-----------------------TVVTPDKSLSAQFEHTVVVTRDGPEILT 253
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 12-193 1.76e-22

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 92.69  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  12 AKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEA--RIEELADGCAFPVNISIDEEAS--HATPgrdDETEFDDG-MV 86
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAarLRRGGARGPAFPPIVASGPNAAipHYIP---NDRVLKPGdLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  87 CLDCGVHVD-GYIADAAVTVdLSGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGY-TPVLNLSGH 159
Cdd:pfam00557  78 LIDVGAEYDgGYCSDITRTF-VVGKPspeqrELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLGH 156

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2279599020 160 GVAQwDAHTGPTIPNRGTDRgvELEVGDVVAIEP 193
Cdd:pfam00557 157 GIGL-EVHEGPYISRGGDDR--VLEPGMVFTIEP 187
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 11-194 9.04e-16

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 74.41  E-value: 9.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  11 LAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEELADGCAFPVNISIDEEAShATPGRDDETEFDDG-MVCLD 89
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAGPTIVGSGARTA-LPHYRPDDRRLQEGdLVLVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  90 CGVHVDGYIADAAVTVdLSGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTP-VLNLSGHGVAQ 163
Cdd:cd01066    80 LGGVYDGYHADLTRTF-VIGEPsdeqrELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPnFGHRTGHGIGL 158

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2279599020 164 WDaHTGPTIPnrgTDRGVELEVGDVVAIEPF 194
Cdd:cd01066   159 EI-HEPPVLK---AGDDTVLEPGMVFAVEPG 185
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 11-296 2.52e-15

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 73.52  E-value: 2.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  11 LAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEE-----------LADGCAFPVNISIDEEASHATPGR-DDE 78
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEelgkvykkekkLEKGIAFPTCISVNNCVCHFSPLKsDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  79 TEFDDG-MVCLDCGVHVDGYIADAAVTV---------DLSGNPELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGY 148
Cdd:cd01089    81 YTLKDGdVVKIDLGCHIDGYIAVVAHTIvvgaeaetpVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 149 GYTPVLNLSGHGVAQwdahtgptipnrgtdrgvelevgdVVaiepfaTTGRGKVtegskeeiyslerdrsvrnrsarKVL 228
Cdd:cd01089   161 GCTPVEGVLSHQLKR------------------------VV------SSGEGKA-----------------------KLV 187

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2279599020 229 EqvkeeyrtlpfaarwldepraemaitrLEQQGVLHGYPVLKEDDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:cd01089   188 E---------------------------CVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLTG 228
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
7-193 3.50e-12

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 65.61  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   7 DEETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEV-AEFAEARIEELADGCAFPVNISIDEEAS--HATPGrddETEFDD 83
Cdd:COG0006    75 SPEEIELMRKAARIADAAHEAALAALRPGVTEREVaAELEAAMRRRGAEGPSFDTIVASGENAAipHYTPT---DRPLKP 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  84 G-MVCLDCGVHVDGYIADAAVTVDLsGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLS 157
Cdd:COG0006   152 GdLVLIDAGAEYDGYTSDITRTVAV-GEPsdeqrEIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHG 230

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2279599020 158 -GHGVAQwDAHTGPTIpnrGTDRGVELEVGDVVAIEP 193
Cdd:COG0006   231 tGHGVGL-DVHEGPQI---SPGNDRPLEPGMVFTIEP 263
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 11-193 1.50e-10

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 59.45  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  11 LAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFAEARIEEL-ADGCAFPVNISIDEEAS--HATPGrDDETEFDDgMVC 87
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLgAEGPSFDTIVASGPNSAlpHGVPS-DRKIEEGD-LVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  88 LDCGVHVDGYIADAAVTVDLsGNP-----ELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTPVLNLS-GHGV 161
Cdd:cd01092    79 IDFGAIYDGYCSDITRTVAV-GEPsdelkEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRtGHGV 157

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2279599020 162 AQwDAHTGPTIPNRGTDrgvELEVGDVVAIEP 193
Cdd:cd01092   158 GL-EVHEAPYISPGSDD---VLEEGMVFTIEP 185
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-296 3.85e-10

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 59.85  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020   9 ETLAKYREAGSVLRQVLDEAVEKVEPGVTHLEVAEFA-EARIEelADGCAFPVN---------ISIDEEASHATPgrdDE 78
Cdd:PLN03158  141 EQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVhEATIA--AGGYPSPLNyhffpksccTSVNEVICHGIP---DA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020  79 TEFDDG-MVCLDCGVHVDGYIADAAVT-----VDLSGNpELVEAAEEALDAALDAVAPGVETGVVGGEIEDVIRGYGYTP 152
Cdd:PLN03158  216 RKLEDGdIVNVDVTVYYKGCHGDLNETffvgnVDEASR-QLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSV 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2279599020 153 VLNLSGHGVAQWdAHTGPTIPNRGTDRGVE-LEVGDVVAIEPFATTGrgkvtegskeeiysLERDRSvrnrsarkvleqv 231
Cdd:PLN03158  295 VKSYCGHGIGEL-FHCAPNIPHYARNKAVGvMKAGQVFTIEPMINAG--------------VWRDRM------------- 346

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2279599020 232 keeyrtlpfaarWLDEPRAEMAitrleqqgvlhgypvlkedDGELVSQAEHTVVVTEDGYENLTA 296
Cdd:PLN03158  347 ------------WPDGWTAVTA-------------------DGKRSAQFEHTLLVTETGVEVLTA 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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