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Conserved domains on  [gi|2290030465|ref|WP_258431766|]
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MFS transporter [Lentilactobacillus buchneri]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-435 2.63e-67

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17503:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 380  Bit Score: 219.37  E-value: 2.63e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17503     5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:cd17503    85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGifiikqytptehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkALFKLSVF 241
Cdd:cd17503   165 LLA---------------------------------------------------------------------PLLDLRLF 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 KRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFL 321
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 322 VQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSV-- 399
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtq 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2290030465 400 --------HIYTLSYVQNIVVGSRLAFAMLALLGVVNFFLFRRL 435
Cdd:cd17503   336 fhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 2-435 2.63e-67

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 219.37  E-value: 2.63e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17503     5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:cd17503    85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGifiikqytptehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkALFKLSVF 241
Cdd:cd17503   165 LLA---------------------------------------------------------------------PLLDLRLF 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 KRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFL 321
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 322 VQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSV-- 399
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtq 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2290030465 400 --------HIYTLSYVQNIVVGSRLAFAMLALLGVVNFFLFRRL 435
Cdd:cd17503   336 fhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 2-397 2.74e-51

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 179.88  E-value: 2.74e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:TIGR00711  11 TFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:TIGR00711  91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGIFIIKQYTPTEHYEFDWLRFGVLALAMITLLMGFNIVGQRG-FLVKFICYM-VVSAASFCLFGWLSKSSHKALFKLS 239
Cdd:TIGR00711 171 VVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILsITGLVAIIAFVVWELTDDNPLVDLR 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 240 VFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSL 319
Cdd:TIGR00711 251 LFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLIL 330

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2290030465 320 FLVQI-VIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMT 397
Cdd:TIGR00711 331 YAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-387 5.05e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.09  E-value: 5.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:COG2814    18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:COG2814    98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 161 LLLGIFIIKQYTPtehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlSKSSHKALFKLSV 240
Cdd:COG2814   178 LLLLLRLLPESRP------------------------------------------------------AARARLRGSLREL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 FKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGnslF 320
Cdd:COG2814   204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG---L 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290030465 321 LVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSL 387
Cdd:COG2814   281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
PRK10504 PRK10504
putative transporter; Provisional
 3-391 6.76e-23

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 100.58  E-value: 6.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   3 FMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYW 82
Cdd:PRK10504   20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  83 TLLVGRLVQagcvGLTGPLMNNI----ILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITL 158
Cdd:PRK10504  100 ELLLARVLQ----GVGGAMMVPVgrltVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGI 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 159 VLLLLGIFIIKQYTpTEHYEFDWLRFGVLALAMITLLMGFNivGQRGFLVK---FICYMVVSAASFCLFGWLSKSSHKAL 235
Cdd:PRK10504  176 IGAIATLMLMPNYT-MQTRRFDLSGFLLLAVGMATLTLALD--GSKGLGLSplaIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 236 FKLSVFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPgSVLNGLG-QPIYGWMLDRFGGKLPLY 314
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIP-MVLGSMGmKRIVVQVVNRFGYRRVLV 331

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2290030465 315 LGN-SLFLVQIVIMMVMGQQMSVLVITILYTVyATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTV 391
Cdd:PRK10504  332 ATTlGLALVSLLFMLVALLGWYYLLPFVLFLQ-GMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
MFS_1 pfam07690
Major Facilitator Superfamily;
1-389 1.19e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.56  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFP-TLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP 79
Cdd:pfam07690   4 AAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  80 NYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLV 159
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 160 LLLLGIFIIKQYTPTEHYEFDwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsKSSHKALFKLS 239
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAE------------------------------------------------EARLSLIVAWK 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 240 VFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNsASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSL 319
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 320 FLVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGT 389
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 2-435 2.63e-67

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 219.37  E-value: 2.63e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17503     5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:cd17503    85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGifiikqytptehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkALFKLSVF 241
Cdd:cd17503   165 LLA---------------------------------------------------------------------PLLDLRLF 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 KRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFL 321
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 322 VQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSV-- 399
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtq 335

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2290030465 400 --------HIYTLSYVQNIVVGSRLAFAMLALLGVVNFFLFRRL 435
Cdd:cd17503   336 fhhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 2-397 2.74e-51

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 179.88  E-value: 2.74e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:TIGR00711  11 TFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:TIGR00711  91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGIFIIKQYTPTEHYEFDWLRFGVLALAMITLLMGFNIVGQRG-FLVKFICYM-VVSAASFCLFGWLSKSSHKALFKLS 239
Cdd:TIGR00711 171 VVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILsITGLVAIIAFVVWELTDDNPLVDLR 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 240 VFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSL 319
Cdd:TIGR00711 251 LFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLIL 330

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2290030465 320 FLVQI-VIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMT 397
Cdd:TIGR00711 331 YAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 2-417 3.53e-39

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 144.62  E-value: 3.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17321     5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:cd17321    85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGIFIikqytptehyefdwlRFGVLALAMITLLMGfnivgqrgflvkficymvvsaasfclfgwlsksshkalfklsvf 241
Cdd:cd17321   165 LLARTF---------------SGAVLAAFLLGAALG-------------------------------------------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 krpvflfsflpyvflqysniGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFL 321
Cdd:cd17321   186 --------------------GLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 322 VQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSVHI 401
Cdd:cd17321   246 VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLS 325

                         410
                  ....*....|....*.
gi 2290030465 402 YTLSYVQNIVVGSRLA 417
Cdd:cd17321   326 ANLGDSGVAALLSAAA 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-387 5.05e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.09  E-value: 5.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:COG2814    18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:COG2814    98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 161 LLLGIFIIKQYTPtehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlSKSSHKALFKLSV 240
Cdd:COG2814   178 LLLLLRLLPESRP------------------------------------------------------AARARLRGSLREL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 FKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGnslF 320
Cdd:COG2814   204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG---L 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290030465 321 LVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSL 387
Cdd:COG2814   281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-431 7.48e-25

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 104.97  E-value: 7.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:cd17504     4 AALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQaGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:cd17504    84 LPVLIAGRALQ-GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 161 LLLgifiikqytptehyefdwlrfgvlaLAMITLlmgfNIVGQRGFLVKFICYMVVSAASFclfgwlsksshkalfklsv 240
Cdd:cd17504   163 AAL-------------------------VPLIDL----RLLRRRNVLLANITALLAGFGMF------------------- 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 fkrpvFLFSFLPYVFLQYSNIGLNFmlpsyvqivnsaSAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLF 320
Cdd:cd17504   195 -----MVFQLLPQLLQLPTPTGFGL------------GITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 321 LVQIVIMMVMGQqmSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSVH 400
Cdd:cd17504   258 AVGLLLLALLHS--SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYT 335

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2290030465 401 IYTLSYVQNIVVGSRLAFAMLALLGVVNFFL 431
Cdd:cd17504   336 VSITSGGVPTEGAYVLAFLIGAALALAALLL 366
PRK10504 PRK10504
putative transporter; Provisional
 3-391 6.76e-23

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 100.58  E-value: 6.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   3 FMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYW 82
Cdd:PRK10504   20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  83 TLLVGRLVQagcvGLTGPLMNNI----ILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITL 158
Cdd:PRK10504  100 ELLLARVLQ----GVGGAMMVPVgrltVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGI 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 159 VLLLLGIFIIKQYTpTEHYEFDWLRFGVLALAMITLLMGFNivGQRGFLVK---FICYMVVSAASFCLFGWLSKSSHKAL 235
Cdd:PRK10504  176 IGAIATLMLMPNYT-MQTRRFDLSGFLLLAVGMATLTLALD--GSKGLGLSplaIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 236 FKLSVFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPgSVLNGLG-QPIYGWMLDRFGGKLPLY 314
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIP-MVLGSMGmKRIVVQVVNRFGYRRVLV 331

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2290030465 315 LGN-SLFLVQIVIMMVMGQQMSVLVITILYTVyATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTV 391
Cdd:PRK10504  332 ATTlGLALVSLLFMLVALLGWYYLLPFVLFLQ-GMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 3-391 3.01e-22

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 96.86  E-value: 3.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   3 FMGVLTETSMNVTFPTLMDQFNiSLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYW 82
Cdd:cd17502     6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  83 TLLVGRLVQ-AGCVGLTgPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPItlvll 161
Cdd:cd17502    85 MLIVGRAIQgIGGGGLM-SLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPI----- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 llgifiikqytptehyefdwlrfGVLALAMItllmgfnivgqRGFLVKFICYMVVSAASFclfgwlsksshkalfklsvf 241
Cdd:cd17502   159 -----------------------GGLALALL-----------RTILLSSIFGFLFGGALF-------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 krpvflfsflpyvflqysniGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGG-KLPLYLGNSLF 320
Cdd:cd17502   185 --------------------GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILM 244

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290030465 321 LVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTV 391
Cdd:cd17502   245 SVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 2-256 3.82e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 96.03  E-value: 3.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:COG0477    23 TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:COG0477   103 ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGIFIIKQYTPTEHYEFDWLRFGVLALAMITLLMGFNIVGQRGFLVKFICYMVVSAASFCLFGWLSKSSHKALFKLSVF 241
Cdd:COG0477   183 VLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262

                         250
                  ....*....|....*
gi 2290030465 242 KRPVFLFSFLPYVFL 256
Cdd:COG0477   263 LLLLLLLLLLALLLA 277
MFS_1 pfam07690
Major Facilitator Superfamily;
1-389 1.19e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.56  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFP-TLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP 79
Cdd:pfam07690   4 AAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  80 NYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLV 159
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 160 LLLLGIFIIKQYTPTEHYEFDwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsKSSHKALFKLS 239
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAE------------------------------------------------EARLSLIVAWK 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 240 VFKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNsASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSL 319
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 320 FLVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGT 389
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-345 1.82e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 89.55  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17474     8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFaSWRMIFWITvPITLVLL 161
Cdd:cd17474    88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLL-AALIPVA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 162 LLGIFIIKQYTPTEhyefdwlrfgVLALAMITLLMGFNIVGQRGFLVkficyMVVSAasfclfgwlsksshkalfklsvf 241
Cdd:cd17474   166 FLAILFLLPEPKEK----------AKSSSATKLRDLKKALRGRGLLT-----FLVSA----------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 242 krpvFLFSFLPYVFLQYsniglnfmLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLD-RFGGKLPLYLGNSLF 320
Cdd:cd17474   208 ----FLYFFLYFAFLTY--------LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLY 275

                         330       340
                  ....*....|....*....|....*
gi 2290030465 321 LVQIVIMMVMGQQMSVLVITILYTV 345
Cdd:cd17474   276 ALSLLLLGFVPSLALLLIAIVLFGL 300
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-393 1.90e-19

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 89.56  E-value: 1.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:cd17320     7 LVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:cd17320    87 IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 161 LLLGIFIIKQYTPTEHYEFDWLRFGVLALAMITLLmgfnivgqrgflvKFICYMVVSAASFclfgwlsksshkalfklsv 240
Cdd:cd17320   167 LLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNR-------------RFLGYALALGLSF------------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 fkrpVFLFSFL---PYVFLQYsnIGLNFMLPSYVQIVNSASAFIAGLILlpgsvlnglgqpiyGWMLDRFGGKLPLYLGN 317
Cdd:cd17320   215 ----AGLFAYLaaaPFIYIEQ--LGLSPAQFGLLFALNAIALILGSLLN--------------GRLVRRFGPRRLLRLGL 274

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2290030465 318 SLFLVQIVIMMVM--GQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKdANAIYGTGNMLAGSLGTTVIA 393
Cdd:cd17320   275 LLLLAAALVLLLAalLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT-ASALLGFLQFLIGALAGALVG 351
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 16-407 3.63e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.62  E-value: 3.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  16 FPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCV 95
Cdd:cd17325    19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  96 GLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTE 175
Cdd:cd17325    99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 176 HYEFdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlSKSSHKALFKLSVFKRPVFLFSFLPYVF 255
Cdd:cd17325   179 NKRA------------------------------------------------VSAARLRSGLRLLLRDRRLLALFLAIFV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 256 LQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGnslFLVQIVIMMVMGQQMS 335
Cdd:cd17325   211 LAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG---LLLSAVALLLLPLATS 287

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2290030465 336 VLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSVHIYTLSYV 407
Cdd:cd17325   288 FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-168 1.41e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 77.97  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   2 TFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:cd17324     8 AFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:cd17324    88 ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAA 167


                  ....*..
gi 2290030465 162 LLGIFII 168
Cdd:cd17324   168 LLLWRLL 174
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-440 2.50e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.83  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:COG2271    18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:COG2271    98 FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 161 LLLGIFIIkqytptehyefdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkalfklsv 240
Cdd:COG2271   178 ALLRFWLL------------------------------------------------------------------------ 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 fkrpvflfsFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGnSLF 320
Cdd:COG2271   186 ---------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGL 255

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 321 LVQIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSvh 400
Cdd:COG2271   256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-- 333

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2290030465 401 iytlsyvqnivVGSRLAFAMLALLGVVNFFLFRRLFKSSK 440
Cdd:COG2271   334 -----------TGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 1-168 3.57e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 76.46  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:cd17323     7 LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQA--GCVGLTgpLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITL 158
Cdd:cd17323    87 IAMLIILRFLQGffGSSPLA--IGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISG 164

                         170
                  ....*....|
gi 2290030465 159 VLLLLGIFII 168
Cdd:cd17323   165 FCLILIFLFL 174
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 16-421 1.22e-13

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 72.03  E-value: 1.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  16 FPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCV 95
Cdd:TIGR00710  28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  96 GLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTE 175
Cdd:TIGR00710 108 SAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYE 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 176 HYEFDWLRFGVLALamitllmgfnIVGQRGFLVkficYMVVSAASF-CLFGWLSKSshkalfklsvfkrpvflfsflPYV 254
Cdd:TIGR00710 188 ARIQISTYFETFLL----------LLKSKMFWG----YALIYGASFgGFFAFFSGA---------------------PFV 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 255 FlqysnIGLNFMLPSyvqiVNSASAFIAGLILLPGSVLNglgqpiyGWMLDRFGGKLPLYLGNSLFLVQIVIM---MVMG 331
Cdd:TIGR00710 233 Y-----IDIMGVSPS----VFGLLFALNIIAMIFGGFLN-------GRFIKKWGAKSLLRMGLILFAVSAVLLeitAILG 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 332 QQMSVLVITILYTVyATGRSMAFGNSMAYGLKHLPKdEQKDANAIYGTGNMLAGSLGTTVIATMMTSVHIYTLSYVQNIV 411
Cdd:TIGR00710 297 LGSWAMIIGPMMFV-GIGNSMISSIAMAYALEDFPH-VAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLA 374

                         410
                  ....*....|
gi 2290030465 412 VGSRLAFAML 421
Cdd:TIGR00710 375 VVSVLAFYYL 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-440 2.86e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 71.07  E-value: 2.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   3 FMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYW 82
Cdd:COG2223    15 FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYW 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  83 TLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLL 162
Cdd:COG2223    95 LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 163 LGIFIIKQYTPTEHYEfdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlSKSSHKALfkLSVFK 242
Cdd:COG2223   175 LAWLFLRDPPAGAAAA-------------------------------------------------AKASLRDQ--LEALR 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 243 RPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLgnsLFLV 322
Cdd:COG2223   204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI---VFAL 280

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 323 QIVIMMVMGQQM-SVLVITILYTVYATGRSMAFGNSMAYGLKHLPKdeqKDANAIYGTGNMlAGSLGTTVIATMMTSVHI 401
Cdd:COG2223   281 MALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT---KNAGAVYGLVGA-AGGLGGFLGPLLFGALLD 356

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2290030465 402 YTLSYvqnivvgsRLAFAMLALLGVVNFFLFRRLFKSSK 440
Cdd:COG2223   357 ATGSY--------TAAFLVFAVLALVALVLTLLLYRRPR 387
2_A_01_02 TIGR00880
Multidrug resistance protein;
35-169 5.47e-13

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 66.13  E-value: 5.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  35 TGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHK 114
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2290030465 115 LGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIK 169
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 7-413 4.41e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.07  E-value: 4.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   7 LTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLV 86
Cdd:cd06174    10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  87 GRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSF--ASWRMIFWITVPITLVLLLLG 164
Cdd:cd06174    90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 165 IFIIKQYTPTEHYEFDWLRFGVLALAMitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkalfkLSVFKRP 244
Cdd:cd06174   170 LLVVPDPPESARAKNEEASSKSVLKLL----------------------------------------------KRVLKNP 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 245 VFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNslFLVQI 324
Cdd:cd06174   204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG--LLLMA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 325 VIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSVHIYTL 404
Cdd:cd06174   282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361


                  ....*....
gi 2290030465 405 SYVQNIVVG 413
Cdd:cd06174   362 AFLVLAVLL 370
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 32-342 1.95e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 65.73  E-value: 1.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  32 WVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVqAGCVGLTGPLMNNIILDVVP 111
Cdd:cd06179    36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL-IGIGAGTQGLGAAVASELVP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 112 AHKLGTYMGMANLIVLVAPALGPTFGGAVV--SFASWRMIFWITVpITLVLLLLGIFIIkqYTPTEHY------------ 177
Cdd:cd06179   115 NKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINA-IFNALALILLFFF--YHPPPRPqlhgsstrqklk 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 178 EFDWLRFGVLALAMITLLMGFNIVGQR---------GFLVKFICYMVVsaasFCLFGWLSKSS----HKALFKLSVFKRP 244
Cdd:cd06179   192 RLDWVGLFLLIAGLVLFLLGLSWGGNPypwssahviAPLVIGGVLLIA----FGLYEWKGTKDgllpPRLLFRGRNFALI 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 245 VFLFSFLPYVFLqysniGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGG-KLPLYLGNSLFLVQ 323
Cdd:cd06179   268 LIVAFVEGMIFY-----SLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHiKWQLVAGFVLFTAF 342

                         330
                  ....*....|....*....
gi 2290030465 324 IVIMMVMGQQMSVLVITIL 342
Cdd:cd06179   343 LALLALITPDNKALAIAFS 361
PRK14995 PRK14995
SmvA family efflux MFS transporter;
10-308 1.72e-10

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 62.82  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  10 TSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRL 89
Cdd:PRK14995   23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  90 VQA-GCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFII 168
Cdd:PRK14995  103 LLAiGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 169 KQYTPTEHYEFDWLRFGVLALAmITLLMGFNIVGQRGFLV--KFICYMVVSAASFCLFGWLSKSSHKALFKLSVFKRPVF 246
Cdd:PRK14995  183 PRQAGRRDQPLNLGHALMLIVA-ILLLVYSAKTALKGFLSlwVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRII 261

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2290030465 247 LFSFLPYVFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFG 308
Cdd:PRK14995  262 LSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
17-176 5.24e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 54.49  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  17 PTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVG 96
Cdd:COG2807    42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  97 LTGPLMNNIILDVVPaHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTEH 176
Cdd:COG2807   122 VGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA 200
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-167 1.65e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.96  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPT-VQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP 79
Cdd:cd17473     7 ASTLTVMAGAAIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  80 NYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFaSWRMIFWITVPITLV 159
Cdd:cd17473    87 SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPV 165


                  ....*...
gi 2290030465 160 LLLLGIFI 167
Cdd:cd17473   166 LILVLLFL 173
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 19-168 1.71e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.96  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  19 LMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLT 98
Cdd:cd17325   226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  99 GPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFII 168
Cdd:cd17325   306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-176 7.64e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.06  E-value: 7.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLM-DQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP 79
Cdd:COG2211   236 AYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  80 --NYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKL-------GTYMGMANLIVLVAPALGPTFGGAVVSFASWR--- 147
Cdd:COG2211   316 pgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVaga 395

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2290030465 148 --------MIFWITVPITLVLLLLGIFIIKQYTPTEH 176
Cdd:COG2211   396 aqspsaltGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 12-167 8.92e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 50.64  E-value: 8.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  12 MNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQ 91
Cdd:cd17359    20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  92 AGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIV--------LVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLL 163
Cdd:cd17359   100 GLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIvfgqllayIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG 179


                  ....
gi 2290030465 164 GIFI 167
Cdd:cd17359   180 MLFI 183
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
17-440 1.36e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  17 PTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVG 96
Cdd:COG0738    32 PALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  97 LTGPLMNNIILDVVPAHKlGTYMGMANLIVLVAPALGPTFGGAVVSF---ASWRMIFWItvpITLVLLLLGIFIIKQYTP 173
Cdd:COG0738   112 LLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLI---LAVLLLLLALLFLRSKLP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 174 TEHYEFDwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsKSSHKALFKLSVFKRPVFLFSFLPY 253
Cdd:COG0738   188 EIEEEEE------------------------------------------------EAAGSAASLKSLLKNPRLLLGGLAI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 254 VFLQYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFLVQIVIMMVMGQQ 333
Cdd:COG0738   220 FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 334 MSVLVITILYTVyatGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGnMLAGSLGTTVIATMMTSVhiytlsyvqnivvG 413
Cdd:COG0738   300 WLALIGLALVGL---GLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAF-------------G 362

                         410       420
                  ....*....|....*....|....*..
gi 2290030465 414 SRLAFAMLALLGVVNFFLFRRLFKSSK 440
Cdd:COG0738   363 LRAAFLVPLVCYLLILLLALALKRKRR 389
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-169 5.11e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.31  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   3 FMGVLTETSMNVTFPT-LMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNY 81
Cdd:COG0738   220 FLYVGAEGAIGDWLPLyLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  82 WTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKlGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLL 161
Cdd:COG0738   300 WLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLIL 378


                  ....*...
gi 2290030465 162 LLGIFIIK 169
Cdd:COG0738   379 LLALALKR 386
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 12-166 8.17e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.57  E-value: 8.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  12 MNVTFPTLMDQFNISLPTVQ--WVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRL 89
Cdd:cd17315    16 INGALLYIAKDLGFGLSTSLqgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  90 VQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIV----LVAPALGptFGGAVVSFASWRMIFWITVPITLVLLLLGI 165
Cdd:cd17315    96 LLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMItfgiLLAYLLG--LALSLSPPGWWRLMFALAAVPALLQLLLMF 173


                  .
gi 2290030465 166 F 166
Cdd:cd17315   174 F 174
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
16-176 8.44e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 47.60  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  16 FPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCV 95
Cdd:PRK11102   14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  96 GLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTE 175
Cdd:PRK11102   94 AAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPKE 173


                  .
gi 2290030465 176 H 176
Cdd:PRK11102  174 R 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 12-166 8.85e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 47.74  E-value: 8.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  12 MNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVq 91
Cdd:TIGR00895  36 MGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFL- 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290030465  92 AGcVGLTGPLMNNIILDV--VPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIF 166
Cdd:TIGR00895 115 AG-LGLGGLMPNLNALVSeyAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 50-163 2.36e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  50 FLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVA 129
Cdd:cd17330   233 RLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLA 312

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2290030465 130 PALGPTFGGAVVSFASWRMIFWITVPITLVLLLL 163
Cdd:cd17330   313 RIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 39-391 2.74e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.05  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  39 LMVALLTITSAFLK-------RRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVP 111
Cdd:cd17489    35 LVVGLFTLAALLARpfagrllDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 112 AHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFI-------IKQYTPTEHYEFDWLRF 184
Cdd:cd17489   115 PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVkdpppvaAEEAEAGTRAFRRLVEK 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 185 GVLALAMITLLMGFnivgqrgflvkfiCYMVVSaasfclfgwlsksshkalfklsvfkrpvflfSFLP--YVFLQYSNIG 262
Cdd:cd17489   195 KVLPPALILFLASI-------------AYGAIS-------------------------------TFLPlyAAERGISNAG 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 263 LNFMlpsyvqiVNSASAFIAGlillpgsvlnglgqPIYGWMLDRFGGKLPLYLGnslFLVQIVIMMVMGQQMSVLVITIL 342
Cdd:cd17489   231 LFFT-------VYAIALLLSR--------------PFSGKLSDRKGPKTVIIPG---LLLLALGLLLLSFAGSPWMLLLA 286

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2290030465 343 YTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTV 391
Cdd:cd17489   287 AVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 10-201 4.13e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 45.33  E-value: 4.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  10 TSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRL 89
Cdd:cd17476    15 GSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  90 VQAGCVGLTGPlmnNIILDVVPAHKLGTYMGMA-NLIVLVAP---ALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGI 165
Cdd:cd17476    95 LQGLGPAFLLP---NAMALLGRTYPPGPRKNIVfSLFGATAPlgfALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAI 171

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2290030465 166 FIIKqytptehyefdwLRFGVLALAMITLLMGFNIV 201
Cdd:cd17476   172 FWTS------------PSFIAVLLAVFLGWASFGIW 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
241-440 4.62e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 241 FKRPVFLFSFLPYVFLQYSNIGLNFMLPSYVQIVNsASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLF 320
Cdd:COG2814     7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 321 lvqIVIMMVMGQQMSVLVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTsvh 400
Cdd:COG2814    86 ---ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD--- 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2290030465 401 iytlsyvqniVVGSRLAFAMLALLGVVNFFLFRRLFKSSK 440
Cdd:COG2814   160 ----------LFGWRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-166 6.49e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  39 LMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTY 118
Cdd:cd17329   247 LLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSY 326

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2290030465 119 MGMANLIVLVAPALGPTFGGAVVSFASWRMIFWI--TVPITLVLLLLGIF 166
Cdd:cd17329   327 MGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIlaALGLIAAALLLGLQ 376
PRK03545 PRK03545
putative arabinose transporter; Provisional
 21-163 7.05e-05

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 44.88  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  21 DQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLvqagCVGLTGP 100
Cdd:PRK03545   37 QSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRI----GIAFAHA 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2290030465 101 LMNNI----ILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLL 163
Cdd:PRK03545  113 IFWSItaslAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLL 179
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
186-434 7.05e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.89  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 186 VLALAMITLLMGFNIVGQRGFLVKFICYMVVSAASFCLFGWL---------SKSSHKALFKlSVFKRPVFLFSFLPYVFL 256
Cdd:COG2211   162 LASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGtkerpvpeeEKVSLKESLK-ALLKNRPFLLLLLAYLLF 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 257 QYSNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFLVQIVIMMVMGQQmSV 336
Cdd:COG2211   241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG-NL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 337 LVITILYTVYATGRSMAFGNSMAYGLKHLPKDEQKD-------ANAIYGTGNMLAGSLGTTVIATMMTSVHiYTLSYVQN 409
Cdd:COG2211   320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLALFG-YVAGAAQS 398

                         250       260
                  ....*....|....*....|....*...
gi 2290030465 410 IVVGSRLAFAML---ALLGVVNFFLFRR 434
Cdd:COG2211   399 PSALTGIRLLFFllpAVLLLLAALLLLF 426
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 21-160 8.90e-05

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 44.65  E-value: 8.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  21 DQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGP 100
Cdd:cd17362    32 DWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMH 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290030465 101 LMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVS-FASWRMIFWITVPITLVL 160
Cdd:cd17362   112 AAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADvVGGWRYMYGLAAPPALLL 172
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 17-165 1.19e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.08  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  17 PTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVG 96
Cdd:cd17324   223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2290030465  97 LTGPLMNNIILDVVPAHKlGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGI 165
Cdd:cd17324   303 AAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-170 1.80e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.33  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:cd17319    11 AYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVL 160
Cdd:cd17319    91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL 170

                         170
                  ....*....|
gi 2290030465 161 LLLGIFIIKQ 170
Cdd:cd17319   171 AVLWWFYLRQ 180
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-168 2.16e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVqwvtTGYL-----LMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMC 75
Cdd:cd17473   205 LAFLAMLLFYVIPIQLPFLLQERGGGSAAL----IGLAlaiasLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  76 GLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVlvapalgptFGGAVVSFASWRMIFWITVP 155
Cdd:cd17473   281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF---------FLGQFLSPLVLGPLVNLTGG 351

                         170
                  ....*....|...
gi 2290030465 156 ITLVLLLLGIFII 168
Cdd:cd17473   352 LSGAFLILGVLAL 364
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
37-178 2.31e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 43.09  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  37 YLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLG 116
Cdd:PRK10473   47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2290030465 117 TYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTEHYE 178
Cdd:PRK10473  127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRPARAPA 188
emrD PRK11652
multidrug transporter EmrD;
17-167 2.71e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.97  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  17 PTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVG 96
Cdd:PRK11652   32 ADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTG 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290030465  97 LTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWitvpitlVLLLLGIFI 167
Cdd:PRK11652  112 VGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL-------FLLLLGAGV 175
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 34-169 3.30e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.61  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  34 TTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRlvqaGCVGL----TGPLMNNIILDV 109
Cdd:cd17328    40 QTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR----ALVGIgeasYSPIAPTIIADL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2290030465 110 VPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFA-SWRMIFWITVPITLVLLLLGIFIIK 169
Cdd:cd17328   116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVR 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 46-167 6.57e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  46 ITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLI 125
Cdd:cd06173   262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2290030465 126 VLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFI 167
Cdd:cd06173   342 NSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 12-163 8.30e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.42  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  12 MNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQ 91
Cdd:cd17365    18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2290030465  92 agCVGLTG--PLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLL 163
Cdd:cd17365    98 --GLGLGAamPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
51-178 8.32e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 41.44  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  51 LKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVqAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAP 130
Cdd:PRK09874   77 LADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRAL-LGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGA 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2290030465 131 ALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQ-YTPTEHYE 178
Cdd:PRK09874  156 LLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIREnFQPVSKKE 204
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 23-404 1.64e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  23 FNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLM 102
Cdd:cd17316    31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 103 NNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFAS----WRMIFWITVPITLVLLLLgifiikqytptehye 178
Cdd:cd17316   111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALLL--------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 179 fdwlrfgvlalamitllmgfnivgqrgflvkficymvvsaasfclfgwlsksshkalfklsvfkRPVFLFSFLPYVFLQY 258
Cdd:cd17316   176 ----------------------------------------------------------------RRRTLLLILLWFFISF 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 259 SNIGLNFMLPSYVQIVNSASAFIAGLILLPGSVLNGLGQPIYGWMLDRFGGKLPLYLGNSLFLVQIVIMMVMGQQMSVLV 338
Cdd:cd17316   192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2290030465 339 ITILYTVYATGrSMAFGNSMAYGLKHLPKDEQKDANAIYGTGNMLAGSLGTTVIATMMTSVHIYTL 404
Cdd:cd17316   272 LLLLFILSFFV-GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-176 2.84e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPT-LMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP 79
Cdd:COG2223   213 LYFGTFGSFIGFSSWLPPyLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  80 -NYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVV-SFASWRMIFWITVPIT 157
Cdd:COG2223   293 gSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSYTAAFLVFAVLA 372

                         170
                  ....*....|....*....
gi 2290030465 158 LVLLLLGIFIIKQYTPTEH 176
Cdd:COG2223   373 LVALVLTLLLYRRPRRAAA 391
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 16-198 3.05e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  16 FPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCV 95
Cdd:cd17477    19 LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  96 GLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPtFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQYTPTE 175
Cdd:cd17477    99 AGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP-LLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177

                         170       180
                  ....*....|....*....|....*
gi 2290030465 176 HYEFDWLRFGVLA--LAMITLLMGF 198
Cdd:cd17477   178 AESISLRRLLRIAplALLGAFVAGF 202
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 18-146 3.27e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.52  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  18 TLMDQFNISLptvqwVTTGYLL-MVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMC------GLAPNYWTLLVGRLV 90
Cdd:cd17390   198 YLEERFDLSP-----KTIGYLIsYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLAlsllglALAPSIWLLVLCLTP 272

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2290030465  91 QAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFASW 146
Cdd:cd17390   273 LSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVS 328
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-171 3.49e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.47  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGV--LTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQ-LFVSAALLFIAGDVMCGL 77
Cdd:COG2807   221 TLFFGLqsLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  78 APNYWTLLVGRLVQAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVS-FASWRMIFWITVPI 156
Cdd:COG2807   301 APGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAAL 380

                         170
                  ....*....|....*
gi 2290030465 157 TLVLLLLGIFIIKQY 171
Cdd:COG2807   381 AVLMLVAGLLAGRPY 395
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 54-90 3.70e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 39.68  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2290030465  54 RFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLV 90
Cdd:PRK03893   81 RYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLV 117
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 36-170 3.83e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.12  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  36 GYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCvGLTGPLMnNIILDVVPAHKL 115
Cdd:cd17472    40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVVM-ALLADLTREENR 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2290030465 116 GTYMGMANLIVLVAPALGPTFGGAVVSFASWRMIFWITVPITLVLLLLGIFIIKQ 170
Cdd:cd17472   118 TKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD 172
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 77-225 4.02e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  77 LAPNYWTLLVGRLVqAGCVGLTGPLMNNIILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSFaSWRMIFWITVPI 156
Cdd:cd17388    87 FAPTLWWLYLGRII-AGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGL 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2290030465 157 TLVLLLLGIFIIKQYTPTEHY-EFDWLR---FGVLA-LAMITLLMGFnivgqrgFLVKFICYMV--VSAASFCLFG 225
Cdd:cd17388   165 NGLNFLLGLFVLPESLPPERRrAFRWRRanpFGSLRwLTGFPGLLGL-------LAVFFLIQLIgqVPATTWVLFT 233
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
 27-178 5.29e-03

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 39.10  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  27 LPTVQ--WVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWTLLVGRLVQAGCVGLTGPLMNN 104
Cdd:TIGR00891  44 LTTVDaaSLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGIGMGGEYGSSAA 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2290030465 105 IILDVVPAHKLGTYMGMANLIVLVAPALGPTFGGAVVSF--ASWRMIFWITVpitlVLLLLGIFIIKQYTPTEHYE 178
Cdd:TIGR00891 124 YVIESWPKHLRNKASGLLISGYAVGAVVAAQVYSLVVPVwgDGWRALFFISI----LPIIFALWLRKNIPEAEDWK 195
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 1-163 6.58e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.46  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   1 MTFMGVLTETSMNVTFPTLMDQFNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPN 80
Cdd:cd17333     4 SFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  81 YWTLLVGRLVQAGCVGLTGPLMNNIILDVVPaHKLGTYMGMANLIVLVAPALGPTFGGAVV-SFASWRMIFWITVPITLV 159
Cdd:cd17333    84 IYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLL 162


                  ....
gi 2290030465 160 LLLL 163
Cdd:cd17333   163 LAIL 166
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 31-171 7.71e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 38.44  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465  31 QWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAP--NYWTLLVGRLVQAGCVGLTGPLMNNIILD 108
Cdd:pfam13347 262 SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLAD 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465 109 VVPAHKL-------GTYMGMANLIVLVAPALGPTFGGAVVSFASWRM---------IFWITVPITL---VLLLLGIFIIK 169
Cdd:pfam13347 342 VVDYGELrtgkrreGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAgdsvqspqaVTAIRLLYAVlpaVLFLVALLLLY 421


                  ..
gi 2290030465 170 QY 171
Cdd:pfam13347 422 FY 423
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 4-90 8.90e-03

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 38.15  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290030465   4 MGVLTETSMNVtfptlmdqfNISLPTVQWVTTGYLLMVALLTITSAFLKRRFTNKQLFVSAALLFIAGDVMCGLAPNYWT 83
Cdd:PRK10091   23 MGVLTELAHDV---------GISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLM 93


                  ....*..
gi 2290030465  84 LLVGRLV 90
Cdd:PRK10091   94 LAIGRLV 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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