|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
5-1154 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 2085.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 5 RFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDV-----LGD 79
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKkddvsGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 80 ELAQLTVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQ 159
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 160 QYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQY 239
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 240 MRNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERLEFLFPDPEvraqrR 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDgETEEDYLRKEAKEGLEERLAFLFPDEE-----R 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 319 PEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK05673 316 PEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 399 MPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAE 478
Cdd:PRK05673 396 MPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYEEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 479 PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:PRK05673 476 PELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDFLG 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 559 LRTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALF 638
Cdd:PRK05673 556 LRTLTIIDDALKLIKKRRGI----DVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVALY 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 639 RPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPV 718
Cdd:PRK05673 632 RPGPMESGMIPNFIDRKHGREEIEYP-----HPELEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 719 EMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVV 798
Cdd:PRK05673 707 EMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDKVA 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 799 GLVDECWRMGLKILPPDINSGQYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNsgEQGYFKDLFDLCARSDIKKLNR 878
Cdd:PRK05673 787 VYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEARE--EGGPFKDLFDFCARVDLKKVNK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 879 RILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQSYANVAPWQEQVVLDGERET 958
Cdd:PRK05673 864 RVLESLIKAGAFDSLGPNRAALLASLEDAVDAADQHKKAEASGQFDLFGGLGEEPEDVEVSVPDVEEWDKKEKLAGERET 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 959 LGLYLTGHPITQYLKEIERYAgGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALE 1038
Cdd:PRK05673 944 LGLYLSGHPLDGYEDELRRLR-DTRLADLEPTEGGSVVTVAGLVVSVRRRVTKRGNKMAIVTLEDLSGRIEVMLFSEALE 1022
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1039 KYQHLLEKDRILIASGQVSFDDfsGGLKMTARELMDISEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRsGTIPVH 1118
Cdd:PRK05673 1023 KYRDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERLKQVLEPHR-GTSPVH 1099
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 2293748522 1119 LYYQRIDARAKLRFGATWRVTPTDRLLIDLRTLVGN 1154
Cdd:PRK05673 1100 LYLQDPDAEAELRLGDRWRVTPSDALLGDLKALLGV 1135
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1073 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1649.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1 MAePRFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVLGDE 80
Cdd:COG0587 1 MS-PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 81 LAQLTVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQQ 160
Cdd:COG0587 80 GYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 161 YFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM 240
Cdd:COG0587 160 IFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 241 RNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERLEFLfpdpevraqRRP 319
Cdd:COG0587 240 KSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEgETEEEYLRKLAEEGLERRYPEG---------IPE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 320 EYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSM 399
Cdd:COG0587 311 EYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 400 PDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEP 479
Cdd:COG0587 391 PDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEEP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 480 QLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLGL 559
Cdd:COG0587 471 ELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 560 RTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFR 639
Cdd:COG0587 551 RTLTVIRDALDLIKENRGI----DIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYR 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 640 PGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVE 719
Cdd:COG0587 627 PGPMQGGMVPPYIRRKHGREPVEYP-----HPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKEE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 720 MAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVG 799
Cdd:COG0587 702 MAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQ 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 800 LVDECWRMGLKILPPDINSGQYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNsgEQGYFKDLFDLCARSDIKKLNRR 879
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAARE--ENGPFTSLFDFCRRVDLRKLNKR 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 880 ILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGvLAEAPEQVEQSYANVAPWQEQVVLDGERETL 959
Cdd:COG0587 860 VLEALIKAGAFDSLGPNRRQLLWALEAALDAAQQAQKDKASGQLSLFG-GAGDEEVAEPALPELPEWSEKEKLAAEKEAL 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 960 GLYLTGHPITQYLKEIERYaGGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALEK 1039
Cdd:COG0587 939 GLYLSGHPLDLYREELRRL-GVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGKRMAFVTLEDETGSIEVVVFPEVYER 1017
|
1050 1060 1070
....*....|....*....|....*....|....
gi 2293748522 1040 YQHLLEKDRILIASGQVSFDDfsGGLKMTARELM 1073
Cdd:COG0587 1018 YRRLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-1033 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1560.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSD--------VL 77
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGsrfdkkriSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 78 GDELAQLTVLAANNDGYQNLTLLISRAYQRGYGAaGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAF 157
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYLEGFYY-KPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 158 YQQYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQ 237
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 238 QYMRNEDEMCELFADIPEALINSVEIAKRCN-VTIRLGEYFLP--QFPTGDMTTEDFLVAKSKEGLEERLEFLFPdpevR 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPsyQIPPDFTSQEDYLRHLADEGLRERLAAGPP----G 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 315 AQRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNP 394
Cdd:TIGR00594 316 YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 395 ERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKA 474
Cdd:TIGR00594 396 ERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 475 FAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKF 554
Cdd:TIGR00594 476 LEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 555 DFLGLRTLTIIDWALEMINKRRAktdlPPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIAL 634
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRG----IDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAV 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 635 VALFRPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGK 714
Cdd:TIGR00594 632 NALYRPGPMESGMIPDFIDRKHGREPIEYP-----HPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 715 KNPVEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNT 794
Cdd:TIGR00594 707 KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDI 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 795 DKVVGLVDECWRMGLKILPPDINSGQYHFHVNDDGeIVYGIGAIKGVGEGPIEAIIEARNSGeqGYFKDLFDLCARSDIK 874
Cdd:TIGR00594 787 EKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDKG-IRYGLGAIKGVGESVVKSIIEERNKN--GPFKSLFDFINRVDFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 875 KLNRRILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQSYANVAPWQEQVVLDG 954
Cdd:TIGR00594 864 KLNKKVLEALIKAGAFDSLGPNRKTLLASLDDALDAVSRKKKAEALGQNSLFGALSEGTKPEYVFFPPDEEWPDKKLLAL 943
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2293748522 955 ERETLGLYLTGHPITQYLKEIERYAGGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLF 1033
Cdd:TIGR00594 944 EKETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGLNSVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
5-281 |
1.73e-157 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 469.65 E-value: 1.73e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 5 RFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVLGDELAQL 84
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 TVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQQYFPD 164
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 165 NYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRNED 244
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 2293748522 245 EMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQF 281
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-558 |
4.59e-138 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 418.06 E-value: 4.59e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 290 DFLVAKSKEGLEERleflFPDPevraqRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSL 369
Cdd:pfam07733 1 EYLRKLVEEGLKER----YGEG-----LPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 370 VAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVL 449
Cdd:pfam07733 72 VAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 450 GHPYGFVDRISKLVPPDPGMtLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLY 529
Cdd:pfam07733 152 GLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 2293748522 530 CDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:pfam07733 231 KADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
8-74 |
7.26e-16 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 73.07 E-value: 7.26e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2293748522 8 HLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQS 74
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
5-1154 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 2085.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 5 RFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDV-----LGD 79
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKkddvsGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 80 ELAQLTVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQ 159
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 160 QYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQY 239
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 240 MRNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERLEFLFPDPEvraqrR 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDgETEEDYLRKEAKEGLEERLAFLFPDEE-----R 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 319 PEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK05673 316 PEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 399 MPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAE 478
Cdd:PRK05673 396 MPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYEEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 479 PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:PRK05673 476 PELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDFLG 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 559 LRTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALF 638
Cdd:PRK05673 556 LRTLTIIDDALKLIKKRRGI----DVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVALY 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 639 RPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPV 718
Cdd:PRK05673 632 RPGPMESGMIPNFIDRKHGREEIEYP-----HPELEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 719 EMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVV 798
Cdd:PRK05673 707 EMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDKVA 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 799 GLVDECWRMGLKILPPDINSGQYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNsgEQGYFKDLFDLCARSDIKKLNR 878
Cdd:PRK05673 787 VYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEARE--EGGPFKDLFDFCARVDLKKVNK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 879 RILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQSYANVAPWQEQVVLDGERET 958
Cdd:PRK05673 864 RVLESLIKAGAFDSLGPNRAALLASLEDAVDAADQHKKAEASGQFDLFGGLGEEPEDVEVSVPDVEEWDKKEKLAGERET 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 959 LGLYLTGHPITQYLKEIERYAgGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALE 1038
Cdd:PRK05673 944 LGLYLSGHPLDGYEDELRRLR-DTRLADLEPTEGGSVVTVAGLVVSVRRRVTKRGNKMAIVTLEDLSGRIEVMLFSEALE 1022
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1039 KYQHLLEKDRILIASGQVSFDDfsGGLKMTARELMDISEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRsGTIPVH 1118
Cdd:PRK05673 1023 KYRDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERLKQVLEPHR-GTSPVH 1099
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 2293748522 1119 LYYQRIDARAKLRFGATWRVTPTDRLLIDLRTLVGN 1154
Cdd:PRK05673 1100 LYLQDPDAEAELRLGDRWRVTPSDALLGDLKALLGV 1135
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1073 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1649.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1 MAePRFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVLGDE 80
Cdd:COG0587 1 MS-PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 81 LAQLTVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQQ 160
Cdd:COG0587 80 GYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 161 YFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM 240
Cdd:COG0587 160 IFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 241 RNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERLEFLfpdpevraqRRP 319
Cdd:COG0587 240 KSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEgETEEEYLRKLAEEGLERRYPEG---------IPE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 320 EYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSM 399
Cdd:COG0587 311 EYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 400 PDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEP 479
Cdd:COG0587 391 PDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEEP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 480 QLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLGL 559
Cdd:COG0587 471 ELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 560 RTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFR 639
Cdd:COG0587 551 RTLTVIRDALDLIKENRGI----DIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYR 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 640 PGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVE 719
Cdd:COG0587 627 PGPMQGGMVPPYIRRKHGREPVEYP-----HPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKEE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 720 MAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVG 799
Cdd:COG0587 702 MAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQ 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 800 LVDECWRMGLKILPPDINSGQYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNsgEQGYFKDLFDLCARSDIKKLNRR 879
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAARE--ENGPFTSLFDFCRRVDLRKLNKR 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 880 ILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGvLAEAPEQVEQSYANVAPWQEQVVLDGERETL 959
Cdd:COG0587 860 VLEALIKAGAFDSLGPNRRQLLWALEAALDAAQQAQKDKASGQLSLFG-GAGDEEVAEPALPELPEWSEKEKLAAEKEAL 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 960 GLYLTGHPITQYLKEIERYaGGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALEK 1039
Cdd:COG0587 939 GLYLSGHPLDLYREELRRL-GVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGKRMAFVTLEDETGSIEVVVFPEVYER 1017
|
1050 1060 1070
....*....|....*....|....*....|....
gi 2293748522 1040 YQHLLEKDRILIASGQVSFDDfsGGLKMTARELM 1073
Cdd:COG0587 1018 YRRLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-1033 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1560.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSD--------VL 77
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGsrfdkkriSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 78 GDELAQLTVLAANNDGYQNLTLLISRAYQRGYGAaGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAF 157
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYLEGFYY-KPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 158 YQQYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQ 237
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 238 QYMRNEDEMCELFADIPEALINSVEIAKRCN-VTIRLGEYFLP--QFPTGDMTTEDFLVAKSKEGLEERLEFLFPdpevR 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPsyQIPPDFTSQEDYLRHLADEGLRERLAAGPP----G 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 315 AQRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNP 394
Cdd:TIGR00594 316 YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 395 ERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKA 474
Cdd:TIGR00594 396 ERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 475 FAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKF 554
Cdd:TIGR00594 476 LEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 555 DFLGLRTLTIIDWALEMINKRRAktdlPPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIAL 634
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRG----IDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAV 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 635 VALFRPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGK 714
Cdd:TIGR00594 632 NALYRPGPMESGMIPDFIDRKHGREPIEYP-----HPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 715 KNPVEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNT 794
Cdd:TIGR00594 707 KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDI 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 795 DKVVGLVDECWRMGLKILPPDINSGQYHFHVNDDGeIVYGIGAIKGVGEGPIEAIIEARNSGeqGYFKDLFDLCARSDIK 874
Cdd:TIGR00594 787 EKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDKG-IRYGLGAIKGVGESVVKSIIEERNKN--GPFKSLFDFINRVDFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 875 KLNRRILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQSYANVAPWQEQVVLDG 954
Cdd:TIGR00594 864 KLNKKVLEALIKAGAFDSLGPNRKTLLASLDDALDAVSRKKKAEALGQNSLFGALSEGTKPEYVFFPPDEEWPDKKLLAL 943
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2293748522 955 ERETLGLYLTGHPITQYLKEIERYAGGQRLKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLF 1033
Cdd:TIGR00594 944 EKETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGLNSVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
3-1157 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 1202.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 3 EPRFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNV-------QSD 75
Cdd:PRK06826 2 KMSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVaprsrfdKEP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 76 VLGDELAQLTVLAANNDGYQNLTLLISRAYQRGYgAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCL 155
Cdd:PRK06826 82 DIDNETYHLVLLAKNETGYKNLMKIVSKAFTEGF-YYKPRVDHELLKEHSEGLIALSACLAGEVPRYILKGNYEKAKEAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 156 AFYQQYF-PDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNY 234
Cdd:PRK06826 161 LFYKDIFgKENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDDENRMRFP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 235 SPQQYMRNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERleflFPDPEv 313
Cdd:PRK06826 241 SDEFYLKSPEEMYELFSYVPEALENTVKIAERCNVEFEFGKSKLPKFPLPEgYDPYEYLRELCYEGLKKR----YPNPS- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 314 raqrrPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLN 393
Cdd:PRK06826 316 -----EELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAGSLVAYTLGITKIDPIKYNLLFERFLN 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 394 PERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEK 473
Cdd:PRK06826 391 PERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYAEVDRIAKMIPTELGITIDK 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 474 AFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYcDAEGNhPVTQFDKNDVEYAGLVK 553
Cdd:PRK06826 471 ALELNPELKEAYENDERVRELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQ-KNDGS-IVTQFTMTTLEELGLLK 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 554 FDFLGLRTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIA 633
Cdd:PRK06826 549 MDFLGLRTLTVIRDAVDLIKKNRGI----EIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELKPDSLEDIIA 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 634 LVALFRPGPLQSgmVDNFIDRKHGREEISYpdiqwQHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMG 713
Cdd:PRK06826 625 GISLYRPGPMDS--IPRYIKNKNNPEKIEY-----LHPKLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVRRAMS 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 714 KKNPVEMAKQRGGF--------EDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAA 785
Cdd:PRK06826 698 KKKHDVMEEERKNFiygivdegGPGCIRNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYPVEFMAA 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 786 VMTADMDNTDKVVGLVDECWRMGLKILPPDINSGQYHFHVNDDgEIVYGIGAIKGVGEGPIEAIIEARNSGeqGYFKDLF 865
Cdd:PRK06826 778 LLNSVMGNSDKVAFYIEECRRLGIEVLPPDINESYSKFTVEGD-KIRFGLAAVKNVGENAIDSIVEEREKK--GKFKSLV 854
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 866 DLCARSDIKKLNRRILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQ-SYANVA 944
Cdd:PRK06826 855 DFCERVDTSQINKRAVESLIKAGAFDSLGVYRSQLLAVYEKILDSISKQRKKNIEGQISLFDLIGEEEESSLEiKYPDIK 934
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 945 PWQEQVVLDGERETLGLYLTGHPITQYLKEIERYAG---GQRLKDMHPTDRGKMT-----TAVGLVVAARIMVTKRGNRI 1016
Cdd:PRK06826 935 EFDKKELLAMEKEMLGLYISGHPLEEYEETLKKQTSatiSDIISDEEEDGESKLKdgdkvIIGGIITEVKRKTTRNNEMM 1014
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1017 GICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQVSFDDfSGGLKMTARELMDISEAREKyarGLAISLTDRQID 1096
Cdd:PRK06826 1015 AFLTLEDLYGTVEVIVFPKVYEKYRSLLNEDNIVLIKGRVSLRE-DEEPKLICEEIEPLVINSEK---KLYLRVEDKKDI 1090
|
1130 1140 1150 1160 1170 1180
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2293748522 1097 DQLLNRLRQSLEPHrSGTIPVHLYYQriDARAKLRFGATWRVTPTDRLLIDLRTLVGNEQV 1157
Cdd:PRK06826 1091 KLKLKELKEILKQY-PGNTPVYLYTE--KERKKFKLDRELWVNLSPELINELKELLGEENV 1148
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
6-1150 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 915.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVLGDELAQ-- 83
Cdd:PRK07374 3 FVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMYVINGSIDDPQPKke 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 84 ----LTVLAANNDGYQNLTLLISRAYQRGYGAAG----PIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCL 155
Cdd:PRK07374 83 kryhLVVLAKNATGYKNLVKLTTISHLNGMRGRGifsrPCIDKELLKQYSEGLIVSTACLGGEIPQAILRGRPDVARDVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 156 AFYQQYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRnYS 235
Cdd:PRK07374 163 AWYKEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLR-YT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 236 PQQYMRNEDEMCELFAD------IPEALINSVEIAKRCNVTIRLGEYFLPQFPTGD-MTTEDFLVAKSKEGLEERLEFLF 308
Cdd:PRK07374 242 GTEYIKSEEEMLRLFRDhldpevIQEAIANTVEVAEKVEEYDILGTYRMPRFPIPEgHTAVSYLTEVTEQGLLKRLKLNS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 309 PDpevraQRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLF 388
Cdd:PRK07374 322 LD-----EIDENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGITNIDPVKNGLLF 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 389 ERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPG 468
Cdd:PRK07374 397 ERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYGEADRLAKLIPVVRG 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 469 --MTLEKAFAAE---PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGnHPVTQFDK 543
Cdd:PRK07374 477 kpAKLKAMIGKEspsPEFREKYEKDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNNDG-QVITQYFM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 544 NDVEYAGLVKFDFLGLRTLTIIDWALEMINKRRAKTdlppIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRL 623
Cdd:PRK07374 556 EDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTGER----IDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQVVRDL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 624 KPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLG 703
Cdd:PRK07374 632 KPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFA-----HPLLEPILTETYGIMVYQEQIMKIAQDLAGYSLG 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 704 GADMLRRAMGKKNPVEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFM 783
Cdd:PRK07374 707 QADLLRRAMGKKKVSEMQKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLKAHYPVAYM 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 784 AAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGQYHFHVNDDgEIVYGIGAIKGVGEGPIEAIIEARNSgeQGYFKD 863
Cdd:PRK07374 787 AALLTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDFTPKGN-RILFGLSAVKNLGDGAIRNIIAARDS--DGPFKS 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 864 LFDLCARSDIKKLNRRILEKLIMSGAFDRLGP--HRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEAPEQVEQSY- 940
Cdd:PRK07374 864 LADLCDRLPSNVLNRRSLESLIHCGALDAFSPnaNRAQLIADLDLVLDWASSRARDRASGQGNLFDLLAGSEEEASNDLs 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 941 -----ANVAPWQEQVVLDGERETLGLYLTGHPITQyLKEIERYAGGQRLKDMHPT-DRGKMtTAVGLVVAARIMVTKRGN 1014
Cdd:PRK07374 944 sapkaAPVPDYPPTEKLKLEKELLGFYLSDHPLKQ-LTEPAKLLAPISLSSLEEQpDKAKV-SAIAMIPEMKQVTTRKGD 1021
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1015 RIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQVSFDDFSGGLKMT-ARELMDIsearekyaRGLAISLTDR 1093
Cdd:PRK07374 1022 RMAILQLEDLTGSCEAVVFPKSYERLSDHLMTDTRLLVWAKVDRRDDRVQLIIDdCREIDDL--------RLLLVELDPD 1093
|
1130 1140 1150 1160 1170 1180
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2293748522 1094 QIDD-QLLNRLRQSLEPHRSGT------IPVHLYYQRIDARAKLRFGATWRVTPTDRLLIDLRT 1150
Cdd:PRK07374 1094 QASDiRVQHKLRECLQKHRPERdelgvkIPVVAAVRNGNSVRYVRLGHQFCVKDAQAAVKALQQ 1157
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
6-1160 |
0e+00 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 857.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDvlGDELAQ-L 84
Cdd:PRK06920 3 FVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASIFSE--EEEKSYpL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 TVLAANNDGYQNLtLLISRAYQRGYGAAgpiIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQQYFpD 164
Cdd:PRK06920 81 VLLAENEIGYQNL-LKISSSIMTKSKEG---IPKKWLAHYAKGLIAISPGKDGEIEQLLLEDKESQAEEVARAYQNMF-G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 165 NYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRNED 244
Cdd:PRK06920 156 NFYMSLQHHAIQDELLLQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLKTDQYYLKSSD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 245 EMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGDMTT-EDFLVAKSKEGLEERleFLFPDPEvraqrrpeYDE 323
Cdd:PRK06920 236 EMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETaDMYLRRVCEEGLQKR--YGTPKEV--------HIN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 324 RLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFD 403
Cdd:PRK06920 306 RLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTGPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDID 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 404 VDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEPQLPE 483
Cdd:PRK06920 386 IDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGITLKDAYEESQSLRE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 484 IYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLycdAEGNHPV--TQFDKNDVEYAGLVKFDFLGLRT 561
Cdd:PRK06920 466 FIQGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAI---QEGHNDVyvTQYPADALEELGLLKMDFLGLRN 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 562 LTIIDWALEMINKRRAKTdlppIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPG 641
Cdd:PRK06920 543 LTLLENIIKFIEQKTGKE----IDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYRPG 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 642 PLQSgmVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEMA 721
Cdd:PRK06920 619 PMEQ--IPTFIESKHGKRKIEYL-----HPDLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVSKKNRDILD 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 722 KQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLV 801
Cdd:PRK06920 692 QERKHFVQGCLQNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKIVQYI 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 802 DECWRMGLKILPPDINSGQYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARnsgEQGYFKDLFDLCARSDIKKLNRRIL 881
Cdd:PRK06920 772 RETKRKGFHVLPPSLQRSGYNFQI-EGNAIRYSLLSIRNIGMATVTALYEER---EKKMFEDLFEFCLRMPSKFVTERNL 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 882 EKLIMSGAFDRLGPHRAALMNSLGDALKAADqhakaeaigqvdmfgVLAEAPEQVEQS-YANVA--PWQEQvvLDGERET 958
Cdd:PRK06920 848 EAFVWSGCFDDFGVSRTNLWKSLKGALEYAN---------------LARDLGDAVPKSkYVQGEelSFIEQ--LNKEKEV 910
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 959 LGLYLTGHPITQYLKEIERyAGGQRLKDMHPTDRGKMtTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALE 1038
Cdd:PRK06920 911 LGFYLSSYPTAQYVKLAKE-LEIPSLAQAMRHKKKVQ-RAIVYITSVKVIRTKKGQKMAFITFCDQNDEMEAVVFPETYI 988
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1039 KYQHLLEKDRILIASGQVSFDDFSGGLKMTARELMDISEA-REKYARGLAISLTDrQIDDQLLNRLRQSLEPHrSGTIPV 1117
Cdd:PRK06920 989 HFSDKLQEGAIVLVDGTIELRNHKLQWIVNGLYPLEEMDAyEEKKDASVYVKLPS-QYEKKLLNQVTKILFDY-SGFAKV 1066
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|...
gi 2293748522 1118 HLYYQRidARAKLRFGATWRVTPTDRLLIDLRTLVGNEQVELE 1160
Cdd:PRK06920 1067 LIYYEK--EHKMVQLSRSLSIHPSEECLGALREIVGEENVVVK 1107
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
6-754 |
0e+00 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 604.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVqsdVLGDELAQL- 84
Cdd:PRK09532 3 FVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYV---INGDIEKQKr 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 ------TVLAANNDGYQNLTLLISRAYQRGYGAAG----PIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQC 154
Cdd:PRK09532 80 rrkyhqVVLAKNTQGYKNLVKLTTISHLQGVQGKGifarPCINKELLEQYHEGLIVTSACLGGEIPQAILSGRPDAARKV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 155 LAFYQQYFPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRnY 234
Cdd:PRK09532 160 AKWYKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLR-Y 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 235 SPQQYMRNEDEMCELFAD------IPEALINSVEIAKRCNVTIRLGEYFLPQFPTGDMTTED-FLVAKSKEGLEERLEFl 307
Cdd:PRK09532 239 SGTEYLKSAEEMRLLFRDhlpddvIAEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDtYVEEVAWQGLLERLNC- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 308 fpdpEVRAQRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLL 387
Cdd:PRK09532 318 ----KSRSEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 388 FERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVP--- 464
Cdd:PRK09532 394 FERFLNPERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIPvsr 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 465 --PDPGMTLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNhPVTQFD 542
Cdd:PRK09532 474 gkPTKLKVMISDETPEPEFKEKYDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNNDGA-VITQYF 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 543 KNDVEYAGLVKFDFLGLRTLTIIDWALEMINKRRAKTdlppIDIAAIPLDDK-------------------KSFDMLQRS 603
Cdd:PRK09532 553 MEDLESLGLLKMDFLGLRNLTTIQKTADLIKENRGVE----IDLDQLPLDERkalkilakgeakklpkdvqKTHKLLERG 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 604 ETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREEISYpdiqwQHESLKPVLEPTYGI 683
Cdd:PRK09532 629 DLEGIFQLESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDY-----EHQLLEPILNETYGV 703
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2293748522 684 ILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGY 754
Cdd:PRK09532 704 LVYQEQIMKMAQDLAGYSLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
4-1056 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 586.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 4 PRFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVlGDELAQ 83
Cdd:PRK05672 3 PPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGPDP-DPGGPH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 84 LTVLAANNDGYQNLTLLISRAYQRGyGAAGPIIDRDWLVEHREGLIL-LSGGRMGDVGKFLLRGNHAQVEQCLA-FYQQY 161
Cdd:PRK05672 82 LLVLARDREGYGRLSRLITRARLRA-GKGEYRLDLDDLAEPAGGHWAiLTGCRKGFVILALPYGGDAAALAALAaLLDAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 162 FPDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMR 241
Cdd:PRK05672 161 FADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGERHLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 242 NEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQFPTGDMTTED-FLVAKSKEGLEERleflFPD---PEVRAQr 317
Cdd:PRK05672 241 SGAEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPAsWLRQLTEAGAARR----YGPgipPKARAQ- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 318 rpeyderLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVpVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERV 397
Cdd:PRK05672 316 -------IEHELALIAELGYEGYFLTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 398 SMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLV------PPDPGMTL 471
Cdd:PRK05672 388 EPPDIDVDFEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVsrwsgsADDLQRLR 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 472 EKAFAAEPQLPEiyeadeevkALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGL 551
Cdd:PRK05672 468 QAGLDPESPIPR---------RVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGL 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 552 VKFDFLGLRTLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDM 631
Cdd:PRK05672 539 VKVDVLALGMLSALHRAFDLIAEHRGR----RLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDL 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 632 IALVALFRPGPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRA 711
Cdd:PRK05672 615 VVEVAIVRPGPIQGGMVHPYLRRRNGQEPVTYP-----HPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRA 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 712 MG-KKNPVEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTAD 790
Cdd:PRK05672 690 MAaWRRKGRLERLRERLYDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQ 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 791 -MdntdkvvG------LVDECWRMGLKILPPDINSGQYH----FHVNDDGEIVYGIGAIKGVGEGPIEAIIEARnsgEQG 859
Cdd:PRK05672 770 pM-------GfyspqqLVQDARRHGVEVLPVDVNASGWDatlePLPDGGPAVRLGLRLVRGLGEEAAERIVAAR---ARG 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 860 YFKDLFDLCARSDikkLNRRILEKLIMSGAFDRLGPHR-AALMNSLGDALKAADQHAKAEAIGQVDMFGvlaeAPEQVEQ 938
Cdd:PRK05672 840 PFTSVEDLARRAG---LDRRQLEALADAGALRSLGGDRrQALWAAGAAATERLDLLPGAPASEAAPALP----GMSEGEL 912
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 939 SYANVApwqeqvvldgereTLGLYLTGHPiTQYLKEieryaggqRLKdmhptdrgkmttAVGLVVAARIMVTKRGNRIGI 1018
Cdd:PRK05672 913 VAADYW-------------TTGLSLDSHP-LALLRP--------RLD------------ARGVVSAAELLDVEDGRRVRV 958
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*.
gi 2293748522 1019 C------------------TLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQV 1056
Cdd:PRK05672 959 AgvvthrqrpgtasgvtflTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRV 1014
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
5-1049 |
0e+00 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 584.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 5 RFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSdvlgdelAQL 84
Cdd:PRK07135 2 KLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEVEN-------FRF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 TVLAANNDGYQNLTLLISrayQRGYGAAGPIIDRDwlvehREGLILLSGGRMGdvgkfLLRGNHAQVEQclafyqqyfpD 164
Cdd:PRK07135 75 ILLAKNYSGYKLLNELSS---KKSKNKEIELNDLD-----SDNIIIIDHPKNG-----FYAKNKEQLEL----------K 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 165 NYYlelIRTGRPDEENYLHAAValanerdlpvvatndVRFLVEDDFDAHEIRVAIHDGFTLDdpkrprnyspqqYMRNED 244
Cdd:PRK07135 132 NYY---INSNDPKIENAVYVQE---------------RKLLFAEDNEYLKILNKIGNNKEEN------------SNFKFF 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 245 EMCELFADIPEALINSV-EIAKRCNVTIRLGEYFLPQFPTG-DMTTEDFLVAKSKEGLEERLEFLFPDPEVRaqrrpeyd 322
Cdd:PRK07135 182 DFEKWFEDIDEKILKRTnYLVENINIEFPKKEFNLPDFDNNlGLESDLFLKKILKESVINKKAELKYYPNVK-------- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 323 ERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDF 402
Cdd:PRK07135 254 ERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRITMPDI 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 403 DVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPpdPGMTLEKAFAAEPQL- 481
Cdd:PRK07135 334 DIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIP--NNQSLEEAYDKNKSFf 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 482 PEIYEADEEV-KALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNHPVtQFDKNDVEYAGLVKFDFLGLR 560
Cdd:PRK07135 412 RELISKGDPIyKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTFESKDNYNQV-QYSMEFLEDFGLLKIDLLGLK 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 561 TLTIIDWALEMINKRRAKTDLppIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRP 640
Cdd:PRK07135 491 NLTIIKNIEEKINKELLFDHL--INFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKVGIDSFEDIVAIISLYRP 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 641 GPLQsgMVDNFIDRKhgREEISYPDIqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEM 720
Cdd:PRK07135 569 GPIQ--YIPIYAKNK--KNPKNIEKI---HPEYDEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAISKKDETKL 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 721 AKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGL 800
Cdd:PRK07135 642 DKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALISNSNGSQENIKKY 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 801 VDECWRMGLKILPPDINSGQYHfHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNsgEQGYFKDLFDLCARSDIKKLNRRI 880
Cdd:PRK07135 722 VKEAKNNGIKVYSPDINFSTEN-AVFDNGKIFLPLIMIKGLGSVAIKKIIDERN--KNGKYKNFFDFILRLKFIGISKSI 798
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 881 LEKLIMSGAFDRLGpHRAALMNSLGDALKAADQHAKAEAIGQVDMFGVLAEA-PEQVEQSYANVapwqeQVVLDGERETL 959
Cdd:PRK07135 799 IEKLIKANTLRSFG-NQDTLLNNLELAKNYAETILSKVAKNLYDDYKNFGLDlEFILEEIERDL-----EEESKNEIEYL 872
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 960 GLYLTGHPITQYLKEieryagGQRLKDMHPtdrgKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALEK 1039
Cdd:PRK07135 873 GMSFNAFDTNKLEKN------QIRLKDLRI----NTEYRLAIEVKNVKRLRKANKEYKKVILSDDSVEITIFVNDNDYLL 942
|
1050
....*....|
gi 2293748522 1040 YQHLLEKDRI 1049
Cdd:PRK07135 943 FETLKKGDIY 952
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
6-1122 |
2.96e-178 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 551.18 E-value: 2.96e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVqsdVLGDELAQLT 85
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNI---FVEEQEVTLR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 86 VLAANNDGYQNLtLLISRAYQRGygaagpiiDRDW--LVEHREG--LILLSGGRMGDVGkfllrgnhaqveqclafyqqy 161
Cdd:PRK07279 79 LIAKNTQGYKNL-LKISTAKMSG--------KKQFsdLSQYLEGiaVIVPYFDWSETLE--------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 162 FPDNYYLELirtgRPDeenylhaavALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDD-PKRPRNyspqQYM 240
Cdd:PRK07279 129 LPFDYYIGV----DQE---------TPGSDFKRPILPLRTVRYFESADRETLQMLHAIRDNLSLREvPLVSSD----QEL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 241 RNEDEMCELFAD-IPEALINSVEIAKrcNVTIRLGEYF-LPQFpTGDMTTEDFLVAKSKEGLEERleflfpdpevrAQRR 318
Cdd:PRK07279 192 ISCQSLETLFQErFPQALDNLEKLVS--GISYDFDTDLkLPRF-NRDRPAVEELRELAELGLKEK-----------GLWS 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 319 PEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK07279 258 SPYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMGMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKERYS 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 399 MPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHP-YGFVDRISKLVPPDpgmTLEKAFAA 477
Cdd:PRK07279 338 MPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVPeYELSNLTKKISFRD---SLASVYEK 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 478 EPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLycDAEGNHPVTQFDKNDVEYAGLVKFDFL 557
Cdd:PRK07279 415 NISFRQIINSKLEYQKAFEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPL--KYGDDMMITQYDAHAVEANGLLKMDFL 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 558 GLRTLTIIDWALEMINKRRAKTdlppIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVAL 637
Cdd:PRK07279 493 GLRNLTFVQKMQEKVAKDYGIH----IDIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFEDIVATTSL 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 638 FRPGPlqSGMVDNFIDRKHGREEISYPDiqwqhESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNP 717
Cdd:PRK07279 569 NRPGA--SDYTDNFVKRRHGQEKVDLID-----PVIAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSKKNA 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 718 VEMAKQRGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMtaDMDNTDKV 797
Cdd:PRK07279 642 SEMQKMEEDFLQGALELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIML--NYSSSDYI 719
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 798 VGLVDecwrMGLKILPPDINSGQYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNsgeqgyFKDLFDLCARSDIKKLN 877
Cdd:PRK07279 720 TDALE----FGFEVAKLSINTIPYHDKI-ENKKIYLGLKNIKGLPRDLAYWIIENRP------FSSIEDFLTRLPENYQK 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 878 RRILEKLIMSGAFDRLGPHRAALMNSLGDALKAADqhakaeaigqvDMFGVLAEApeqvEQSYANVAPWQEQVVLDGERE 957
Cdd:PRK07279 789 KEFLEPLIKIGLFDSFEKNRQKIINNLDNLFVFVN-----------ELGSLFADS----SYSWVEAEDYSETEKYSLEQE 853
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 958 TLGLYLTGHPitqyLKEIERYAGgqrlKDMHP-TDRGKMTTAVGLVV--AARIMVTK-RGNRIGICTLDDRSGRLEVMLF 1033
Cdd:PRK07279 854 LLGVGVSKHP----LQAIAEKSS----RPFTPiSQLVKNSEATILVQiqSIRVIRTKtKGQQMAFLSVTDTKKKLDVTLF 925
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1034 TDALEKYQHLLEKDRILIASGQVSFDDfsGGLKMTArelmdiSEAREKYARGLAISLTDRQIDDQLLNRLRQSlephrSG 1113
Cdd:PRK07279 926 PETYRQYKDELKEGKFYYLKGKIQERD--GRLQMVL------QQIQEASSERFWILLENHEHDQEISEILGAF-----PG 992
|
....*....
gi 2293748522 1114 TIPVHLYYQ 1122
Cdd:PRK07279 993 SIPVIIHYQ 1001
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
6-989 |
1.31e-172 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 534.42 E-value: 1.31e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVlgdelAQLT 85
Cdd:PRK05898 2 FINLNTHSHYSLLSSTLSIDDIIKFALDNNQPYVCLTDLNNLYGCIEFYDKAKAHNLIPIIGLEIEYQSTN-----ATLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 86 VLAANNDGYQNLTLLISrayqrgygaagpiidrdWLVEHREglillsggrmgdvgkfllrgnhaqveqclaF-YQQYFPD 164
Cdd:PRK05898 77 LYAKNYNGYLNLIKISS-----------------FIMTNKE------------------------------FeIQDYLDD 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 165 NYYLELIRTGRPDEENYLHAAvalaNERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMrNED 244
Cdd:PRK05898 110 LFIVCKKGTFVFKSPNFYQTH----NQNAPNAIAFNSVFYANKNDKIVFNAMLAIKNDLKIDELKNCQDFDNNHFL-NDN 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 245 EMCELFADIpeALINSVEIAKRCNVTIRLGEYFLPQFPTGDMTTED-FLVAKSKEGLEERLEflfpdpEVRAQRRPEYDE 323
Cdd:PRK05898 185 EAQSLFSPI--QLDNLNKVLNELKVEIHDLPINIIKYDKQNSIISSeILKQLCISGLNKRLN------ANDGQVKKIYVK 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 324 RLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFD 403
Cdd:PRK05898 257 RLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIGPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDID 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 404 VDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEPQLPE 483
Cdd:PRK05898 337 TDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRILGIDLKVIDKICKNIKPDYEEDLDLAIKKNTILKE 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 484 IYEADeevKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEgNHPVTQFDKNDVEYAGLVKFDFLGLRTLT 563
Cdd:PRK05898 417 MYVLH---KELFDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQLGIN-DRPLSQYSMEYLERFGLIKMDLLGLKNLT 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 564 IIDWALEMINKRRAKTdlppIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGPL 643
Cdd:PRK05898 493 IIDNVLKLIKENQNKK----IDLFNINLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQ 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 644 QSgmVDNFIDRKHGREEISYPDiqwqhESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEMAKQ 723
Cdd:PRK05898 569 QN--IKTFVERRFKREEFSYWN-----EATKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAISKKDEKILIQL 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 724 RGGFEDGAKSRGIDGELSIKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVDE 803
Cdd:PRK05898 642 KKDFIEGALKNNYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLNE 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 804 CWRMGLKILPPDINSGQYHFHV-NDDGEIVYGIGAIKGVGEGPIEAIIEARNSGEQGYFKDLFDLCARSDIKKLNrriLE 882
Cdd:PRK05898 722 AKEFNISIKKPDINYSSNSFVLdTQKQIIRFGFNTIKGFGDELLKKIKSALQNKTFSDFISYIDALKKNNVSLSN---IE 798
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 883 KLIMSGAFDRLGPHRAALMNSLGDALKAADQHakaeaigqvdmfGVLAEaPEQVEQSYANVAPWQEQvVLDGERETLGLY 962
Cdd:PRK05898 799 ILINVGTFDSFKLSRLFLLNNLPEIFEKTSLN------------GHFFE-LNLVGLEYAKDMSVKER-FLKKEIQYLGID 864
|
970 980
....*....|....*....|....*..
gi 2293748522 963 LTGHPITQYLKEIERYAGGQRLKDMHP 989
Cdd:PRK05898 865 LNSLNYANYKNEIDYNELKYTIKDIKE 891
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
5-281 |
1.73e-157 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 469.65 E-value: 1.73e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 5 RFIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDVLGDELAQL 84
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 TVLAANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFYQQYFPD 164
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 165 NYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRNED 244
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 2293748522 245 EMCELFADIPEALINSVEIAKRCNVTIRLGEYFLPQF 281
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-558 |
4.59e-138 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 418.06 E-value: 4.59e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 290 DFLVAKSKEGLEERleflFPDPevraqRRPEYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPGRGSGAGSL 369
Cdd:pfam07733 1 EYLRKLVEEGLKER----YGEG-----LPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 370 VAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYGREAVSQIITFGTMAAKAVIRDVGRVL 449
Cdd:pfam07733 72 VAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 450 GHPYGFVDRISKLVPPDPGMtLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLY 529
Cdd:pfam07733 152 GLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 2293748522 530 CDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:pfam07733 231 KADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
561-735 |
5.98e-85 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 272.48 E-value: 5.98e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 561 TLTIIDWALEMINKRRAKtdlpPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRP 640
Cdd:pfam17657 1 TLTIIRDALDLIKENRGI----GIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 641 GPLQSGMVDNFIDRKHGREEISYPdiqwqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEM 720
Cdd:pfam17657 77 GPMQGGNVDDYIKRKHGKEKIEYP-----HPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGKKKPEEM 151
|
170
....*....|....*
gi 2293748522 721 AKQRGGFEDGAKSRG 735
Cdd:pfam17657 152 EKLREKFIEGAKENG 166
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
6-279 |
4.78e-78 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 258.14 E-value: 4.78e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 6 FIHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNV--------QSDVL 77
Cdd:cd12113 2 FVHLHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVapgsrfdkKDKKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 78 GDELAQLTVLAANNDGYQNLTLLISRAYQRG-YGAagPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLA 156
Cdd:cd12113 82 DKRYYHLVLLAKNEEGYRNLMKLVSLAYLEGfYYK--PRIDKELLAKYSEGLIALSACLAGEIPQLLLNGDEEEAREAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 157 FYQQYF-PDNYYLELIRTGRPDEENYLHAAVALANERDLPVVATNDVRFLVEDDFDAHEIRVAIHDGFTLDDPKRPRNYS 235
Cdd:cd12113 160 EYRDIFgKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLDDPNRMRFDT 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2293748522 236 PQQYMRNEDEMCELFADIPEALINSVEIAKRCNVTIRLGEYFLP 279
Cdd:cd12113 240 DEFYLKSPEEMRELFPDVPEALENTLEIAERCNVELDFGKLHLP 283
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
756-1149 |
1.20e-74 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 254.99 E-value: 1.20e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 756 FNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGQYHFHVNDDGeIVYGI 835
Cdd:PRK07373 38 FNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSGNQDKVQKYRENCQKMGIEVEPPDINRSGKDFTPVGEK-ILFGL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 836 GAIKGVGEGPIEAIIEARNSGeqGYFKDLFDLCARSDIKKLNRRILEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHA 915
Cdd:PRK07373 117 SAVRNLGEGAIESILKAREEG--GEFKSLADFCDRVDLRVVNRRALETLIYCGAFDKIEPNRQQLINDLELVIDWAQKRA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 916 KAEAIGQVDMFGVL---AEAPEQVEQSY--ANVAP----WQEQVVLDGERETLGLYLTGHPitqyLKEIERYA---GGQR 983
Cdd:PRK07373 195 KEKASGQGNLFDLLggnTSNSSAANNAFeqAPSAPpvadFSLQEKLKLEKELLGFYVSEHP----LKSIRRPArllSPIN 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 984 LKDMHPTDRGKMTTAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQVSFDDFSG 1063
Cdd:PRK07373 271 LSELEEQKEKTKVSAVVMLNEVKKIVTKKGDPMAFLQLEDLSGQSEAVVFPKSYERISELLQVDARLIIWGKVDRRDDQV 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 1064 GLkmtareLMDISEAREKyARGLAISLTDRQIDD-QLLNRLRQSLEPH----RSGTIPVHLYYQRIDARAKLRFGATWRV 1138
Cdd:PRK07373 351 QL------IVEDAEPIEE-VRMVMVELSPQQAGNiVSQHRLKEILQEQagdkNKAKVPVIAIIQSGGNRQLVRLGQQYWV 423
|
410
....*....|.
gi 2293748522 1139 TPTDRLLIDLR 1149
Cdd:PRK07373 424 QDEHSAVQALQ 434
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
8-173 |
3.86e-41 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 149.23 E-value: 3.86e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 8 HLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDV------LGDEL 81
Cdd:pfam02811 1 HLHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVAPGSreetekLLAKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 82 AQLTVLAANNDGYQNLTLLISRAYQRGYgaaGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLR-GNHAQVEQCLAFYQQ 160
Cdd:pfam02811 81 FDLVLLAVHEVGYKNLIKLSSRAYLEGF---KPRIDKELLEEYFEGLIALSGCVLGHLDLILLApGDYEEAEELAEEYLE 157
|
170
....*....|....
gi 2293748522 161 YFP-DNYYLELIRT 173
Cdd:pfam02811 158 IFGeDGFYLEINTH 171
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
8-271 |
4.03e-32 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 123.47 E-value: 4.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 8 HLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQSDvlgDELAQLTVL 87
Cdd:cd07431 2 HLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVEGD---GEPYPLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 88 AANNDGYQNLTLLISRAYQRGYGAAGPIIDRDWLVEHREG-LILLSGGRMgdvgkfllrgnhaqveqclafyqqyfpdny 166
Cdd:cd07431 79 AKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEELAEAASGlLVVLLGPLL------------------------------ 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 167 ylelirtgrpdeenylhaaVALANERDLPVVATNDVRFLVEDDFDAHEIRVAihdgftlddpkrprnyspqqymrnedem 246
Cdd:cd07431 129 -------------------LLLAAEQGLPLVATNDVHYLNPEDAFAADVLTA---------------------------- 161
|
250 260
....*....|....*....|....*
gi 2293748522 247 celfadiPEALINSVEIAKRCNVTI 271
Cdd:cd07431 162 -------FLAVANTVRIAKECAVEL 179
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
85-893 |
2.08e-31 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 134.20 E-value: 2.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 85 TVLAANNDGYQNLTLLISRAYQRgYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGNHAQVEQCLAFY-----Q 159
Cdd:PRK00448 614 TILVKNQVGLKNLFKLVSLSNTK-YFYRVPRIPRSLLDKYREGLLIGSACEEGEVFDAVLQKGDEELEEIAKFYdyieiQ 692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 160 QyfPDNY----YLELIRtgrpDEENyLHAA----VALANERDLPVVATNDVRFLVEDDFDAHEIRVAihdGFTLDDPKRp 231
Cdd:PRK00448 693 P--PANYqhliERELVK----DEEE-LKEIiknlIELGKKLNKPVVATGDVHYLDPEDKIYRKILVA---SQGGGNPLN- 761
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 232 RNYSPQQYMRNEDEMCELFADIPEALI------NSVEIAKRC-NVTIRLGEYFLPQFPTGDMTTEDFLVAKSKEGLEERL 304
Cdd:PRK00448 762 RHPLPELHFRTTDEMLDEFAFLGEELAkeivveNTNKIADLIeEIEPIKDKLYTPKIEGAEEEIRELTYKKAHEIYGEPL 841
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 305 eflfpdPEVraqrrpeYDERLDTELKVINQMGFPGYFLIVMEFIQWSKDNNVPVGPgRGSGAGSLVAYALKITDLDPLE- 383
Cdd:PRK00448 842 ------PEI-------VEKRIEKELNSIIGNGFAVIYLISQKLVKKSLEDGYLVGS-RGSVGSSFVATMIGITEVNPLPp 907
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 384 ---------------------FDLL-------------------FERFLNPERVSMPDFDVDFCMEKRDLVIEHVAEMYG 423
Cdd:PRK00448 908 hyvcpnckysefftdgsvgsgFDLPdkdcpkcgtklkkdghdipFETFLGFKGDKVPDIDLNFSGEYQPVAHNYTKVLFG 987
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 424 REAVSQIITFGTMAAKAVirdvgrvlghpYGFVdrisKLVPPDPGMTLEKAFaaepqlpeiyeadeevkalID-MARKLE 502
Cdd:PRK00448 988 EDHVFRAGTIGTVAEKTA-----------YGYV----KKYEEDTGKFYRNAE-------------------IDrLAQGCT 1033
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 503 GVTRNAGKHAGGVVIAPT--KITDFAPLycdaegNHP---------VTQFDKNDVeYAGLVKFDFLGLRTLTIIdwalem 571
Cdd:PRK00448 1034 GVKRTTGQHPGGIIVVPKymDIYDFTPI------QYPaddvnsewkTTHFDFHSI-HDNLLKLDILGHDDPTMI------ 1100
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 572 inkrRAKTDLPPIDIAAIPLDDKKsfdmlqrseTTAVF-----------QLES---------------RGMkdlIKRLKP 625
Cdd:PRK00448 1101 ----RMLQDLTGIDPKTIPMDDPK---------VMKLFsstealgvtpeQIGCetgtlgipefgtkfvRQM---LEETKP 1164
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 626 DCFEDMIALvalfrpgplqSGMvdnfidrKHGR-------EEIsypdIQWQHESLKPV---------------LEPTY-- 681
Cdd:PRK00448 1165 KTFAELVQI----------SGL-------SHGTdvwlgnaQEL----IKEGIATLSDVigcrddimvylihkgLEPKLaf 1223
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 682 ----------GIILYQEQVMQIAQVLAGYtlggadmlrramgkknpvemakqrggfedgaksrgIDGELSIKifdlvekf 751
Cdd:PRK00448 1224 kimesvrkgkGLTEEEEELMKENNVPDWY-----------------------------------IESCKKIK-------- 1260
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 752 agYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAA------------VMTA-----------------DMDNTDK----VV 798
Cdd:PRK00448 1261 --YMFPKAHAAAYVLMAWRIAYFKVHYPLAYYAAyfsvraddfdleTMSKgkeaikakmkeikskgnDASNKEKdlltVL 1338
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 799 GLVDECWRMGLKILPPDINSGQYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNSGEqgyFKDLFDLCARSdikKLNR 878
Cdd:PRK00448 1339 EIALEMLERGFKFQKVDLYKSDATEFIIEGDSLIPPFNALPGLGENVAKSIVEAREEGE---FLSKEDLRKRT---KVSK 1412
|
970
....*....|....*
gi 2293748522 879 RILEKLIMSGAFDRL 893
Cdd:PRK00448 1413 TLIEKLDELGVLDDL 1427
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
808-900 |
1.03e-30 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 116.03 E-value: 1.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 808 GLKILPPDINSGQYHFHVNDdGEIVYGIGAIKGVGEGPIEAIIEARNSGEqgyFKDLFDLCARSDiKKLNRRILEKLIMS 887
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVEG-GGIRLGLGAIKGLGEAAAERIVEERENGP---FKSLEDFARRVD-LKLNKRVLEALIKA 75
|
90
....*....|...
gi 2293748522 888 GAFDRLGPHRAAL 900
Cdd:pfam14579 76 GAFDSLGGNRRQL 88
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
7-264 |
8.98e-26 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 107.94 E-value: 8.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 7 IHLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQsdvlgdELAQLTV 86
Cdd:cd07435 2 VELHAHTKMSAMDGVTSVKELVKRAAEWGHKAIAITDHGVVQAFPEAYEAAKKNGIKVIYGVEAYLV------DPYHITI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 87 LAANNDGYQNLTLLISRAYQRgYGAAGPIIDRDWLVEHREGLILLSGGRMGDVGKFLLRGN-HAQVEQCLAFYqQYF--- 162
Cdd:cd07435 76 LVKNQTGLKNLYKLVSLSHTK-YFYRVPRIPKSELEKYREGLLIGSACENGELFEAALNKKsDEELEEIASFY-DYIeiq 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 163 PDNYYLELIRTGRPDEENYLHAA----VALANERDLPVVATNDVRFLVEDDfdaHEIRVAIHDGFTLDDPKrpRNYSPQQ 238
Cdd:cd07435 154 PLDNYQFLIEKGLIKSEEELKEInkriIKLGKKLNKPVVATGDVHYLDPED---KIYREILLAGQGGGDGR--ADEQPDL 228
|
250 260 270
....*....|....*....|....*....|..
gi 2293748522 239 YMRNEDEMCELFADIPEALI------NSVEIA 264
Cdd:cd07435 229 YFRTTDEMLDEFSYLGEEKAyevvvtNTNKIA 260
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
997-1082 |
2.01e-25 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 100.66 E-value: 2.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 997 TAVGLVVAARIMVTKRGNRIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQVSFDDfsGGLKMTARELMDIS 1076
Cdd:cd04485 1 TVAGLVTSVRRRRTKKGKRMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERRD--GGLRLIAERIEDLE 78
|
....*.
gi 2293748522 1077 EAREKY 1082
Cdd:cd04485 79 DARERL 84
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
41-268 |
6.47e-24 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 102.53 E-value: 6.47e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 41 ITDFTNLCGLVKFYGSAHGAGIKPIIGADFnvqsdVLGDELaQLTVLAANNDGYQNLTLLISRAYQRG----YgaagpII 116
Cdd:cd07434 36 ITDECSLAGVVRAHAAAKELGLKLIVGSEL-----VLADGT-RLVLLARDRAGYGRLCRLITLGRRRAekgeY-----RL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2293748522 117 DRDWLVEHREGLILLsggRMGDVGKFLLRGNHAQVEQCLAFyqqyFPDNYYLELIRTGRPDEENYLHAAVALANERDLPV 196
Cdd:cd07434 105 TLADLLAHAEGLLLI---LLPPDRLPAAAALLAQLRWLARA----FPGRLWLALELHLGGDDARRLARLAALAAALGLPL 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2293748522 197 VATNDVRFLVEDDFDAHEIRVAIHDGFTLDD--PKRPRNysPQQYMRNEDEMCELFADIPEALINSVEIAKRCN 268
Cdd:cd07434 178 VATGDVLMHSPSRRPLQDVLTAIRLGTTVAEagRRLAAN--AERHLRSPAELARLFLYPPEALAETLEIAARCT 249
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
8-74 |
7.26e-16 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 73.07 E-value: 7.26e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2293748522 8 HLRVHSDYSMIDGLAKIGPLVKRAAALAMPALAITDFTNLCGLVKFYGSAHGAGIKPIIGADFNVQS 74
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIVD 67
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
1002-1075 |
3.34e-10 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 57.24 E-value: 3.34e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2293748522 1002 VVAARIM-VTKRGNRIGICTLDDRSGRLEVMLFTDALEKYQHLLEKDRILIASGQVSFDDFsGGLKMTARELMDI 1075
Cdd:pfam01336 2 TVAGRVTsIRRSGGKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRKG-GELELVVEEIELL 75
|
|
| PHP |
cd07309 |
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2 ... |
7-72 |
8.15e-10 |
|
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP in polymerases has trinuclear zinc/magnesium dependent proofreading activity. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213985 [Multi-domain] Cd Length: 88 Bit Score: 56.67 E-value: 8.15e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2293748522 7 IHLRVHSDYSMIDgLAKIGPLVKRAAALAMPALAITDFTNLCGLVKF--------YGSAHGAGIKPIIGADFNV 72
Cdd:cd07309 1 VDLHTHTVFSDGD-HAKLTELVDKAKELGPDALAITDHGNLRGLAEFntagk*nhIKAAEAAGIKIIIGSEVNL 73
|
|
| |
