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Conserved domains on  [gi|2302977120|ref|WP_260069044|]
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MFS transporter [Paenibacillus sp. p3-SID867]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-398 9.45e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17325:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 95.72  E-value: 9.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVNSEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESLGASVA-QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTEsKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAIL 173
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 174 SALTFPLLLAIKTSSRGVVQHVEN---KNSKALLFMVKDRRFIVLLLTGFVISLLFqGYVKSTLSYWIEmrdfsalslLS 250
Cdd:cd17325   160 ALLALVLALLLLPEPRPPPNKRAVsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAF-GALEPFLPLYAA---------EL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTLKLAADPFLGYWVGRFSDiRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2302977120 331 LDTDAAqYAADSSNKHYVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLRVK 398
Cdd:cd17325   309 TLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
 
Name Accession Description Interval E-value
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 14-398 9.45e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.72  E-value: 9.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVNSEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESLGASVA-QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTEsKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAIL 173
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 174 SALTFPLLLAIKTSSRGVVQHVEN---KNSKALLFMVKDRRFIVLLLTGFVISLLFqGYVKSTLSYWIEmrdfsalslLS 250
Cdd:cd17325   160 ALLALVLALLLLPEPRPPPNKRAVsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAF-GALEPFLPLYAA---------EL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTLKLAADPFLGYWVGRFSDiRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2302977120 331 LDTDAAqYAADSSNKHYVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLRVK 398
Cdd:cd17325   309 TLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-312 4.17e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.86  E-value: 4.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   8 KNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASP-AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL 167
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 168 IGFAILSALTFPLLLAIKTSSRGVVQHvenKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFsals 247
Cdd:COG2814   168 LVNAVLALLALLLLLRLLPESRPAARA---RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL---- 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2302977120 248 llssisAATLTGILLTLKLAADPFLGYWVGRFSD-IRQSRTEWLTGSIMAVGILFVIIAFHLQTVV 312
Cdd:COG2814   241 ------SASAAGLLLALFGLGGVLGALLAGRLADrFGRRRLLLIGLLLLALGLLLLALAGSLWLLL 300
MFS_1 pfam07690
Major Facilitator Superfamily;
14-364 3.57e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.14  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVN-SEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYG 92
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLlAEDLGISPT-EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  93 YFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAI 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER-GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 173 LSALTFPLLL--AIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSLLS 250
Cdd:pfam07690 160 LSLLAAVLLLlpRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTlklaadPFLGYWVGRFSDIRQSrteWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:pfam07690 240 LLGLGGLLGAIGR------LLLGRLSDRLGRRRRL---LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2302977120 331 LDTDAAQYAADSSNKHYVVSSYSMTVDIGAALGP 364
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 14-398 9.45e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.72  E-value: 9.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVNSEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYAESLGASVA-QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTEsKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAIL 173
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 174 SALTFPLLLAIKTSSRGVVQHVEN---KNSKALLFMVKDRRFIVLLLTGFVISLLFqGYVKSTLSYWIEmrdfsalslLS 250
Cdd:cd17325   160 ALLALVLALLLLPEPRPPPNKRAVsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAF-GALEPFLPLYAA---------EL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTLKLAADPFLGYWVGRFSDiRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2302977120 331 LDTDAAqYAADSSNKHYVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLRVK 398
Cdd:cd17325   309 TLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-312 4.17e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.86  E-value: 4.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   8 KNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASP-AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL 167
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 168 IGFAILSALTFPLLLAIKTSSRGVVQHvenKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFsals 247
Cdd:COG2814   168 LVNAVLALLALLLLLRLLPESRPAARA---RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL---- 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2302977120 248 llssisAATLTGILLTLKLAADPFLGYWVGRFSD-IRQSRTEWLTGSIMAVGILFVIIAFHLQTVV 312
Cdd:COG2814   241 ------SASAAGLLLALFGLGGVLGALLAGRLADrFGRRRLLLIGLLLLALGLLLLALAGSLWLLL 300
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 8-185 2.07e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.15  E-value: 2.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   8 KNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:cd17325   199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL 167
Cdd:cd17325   279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGR-GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357

                         170
                  ....*....|....*...
gi 2302977120 168 IGFAILSALTFPLLLAIK 185
Cdd:cd17325   358 LAAAALLLLAAVLFLLLR 375
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 42-396 1.15e-13

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 71.87  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  42 ALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLL 121
Cdd:cd17329    33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 122 VVeAVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSALTFPLLLAIKTSSRGVVQHVENKNSK 201
Cdd:cd17329   113 IA-DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 202 ALLFMVKDRRFIVLLLTGFVISLLFqGYVKSTLSywIEMRDFSALSLLSSISAATLTGILLTLklaadpfLGYWVGRFSD 281
Cdd:cd17329   192 GYKIVLRDRAFLLFLLASFLISLIY-FQLESTLP--VYVVEILGLGESLLGLLLALNALLIVL-------LQFPVARLVE 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 282 IRQSRTEWLTGSIMAvGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTLLDTDAAQYAADSSNKHYvVSSYSMTVDIGAA 361
Cdd:cd17329   262 RFRLRKILMIGILLF-AIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSY-MGFYALAWGLGRA 339

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2302977120 362 LGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLR 396
Cdd:cd17329   340 IGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
MFS_1 pfam07690
Major Facilitator Superfamily;
14-364 3.57e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.14  E-value: 3.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVN-SEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYG 92
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLlAEDLGISPT-EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  93 YFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAI 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER-GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 173 LSALTFPLLL--AIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSLLS 250
Cdd:pfam07690 160 LSLLAAVLLLlpRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTlklaadPFLGYWVGRFSDIRQSrteWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:pfam07690 240 LLGLGGLLGAIGR------LLLGRLSDRLGRRRRL---LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2302977120 331 LDTDAAQYAADSSNKHYVVSSYSMTVDIGAALGP 364
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-395 7.76e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.38  E-value: 7.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  13 AAFITAVSLFGDAMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYG 92
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSA-SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  93 YFNEFIALLIARCVWGVAWAFIKQAGQLLVVEaVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFdTSSVLIGFAI 172
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD-LFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-GFGWRAVFLI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 173 LSALTFPLLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMrdFSALSLLSSI 252
Cdd:cd06174   158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL--LPLFLLDLGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 253 SAATLTGILLTLKLAADPFLGYWVGRFSDIRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTLLd 332
Cdd:cd06174   236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS- 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2302977120 333 TDAAQYAADSSNKHYVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLL 395
Cdd:cd06174   315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-403 1.07e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.14  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   9 NMIIAAFITAVSlFGDAMLYAVLPVN-SEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:COG2223     6 VLLLATLAFFLA-FGVWYLWSVLAPPlAEEFGLSAA-QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL 167
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR-GLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 168 IGFAILSALTFPLLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALS 247
Cdd:COG2223   163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 248 LLSSISAATLTGILLTlklaadPFLGYWVGRFsdirqSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIV 327
Cdd:COG2223   243 AGLLAALFALLGALGR------PLGGWLSDRI-----GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 328 TTLLdtdAAQYAADSSNKHYVVSSYSMtVDIGAALGPFLGFTLLSVIGDTFLN-----VGAALLLVLCGFVLLRVKKRNR 402
Cdd:COG2223   312 GNGA---VFALVPDIFPTKNAGAVYGL-VGAAGGLGGFLGPLLFGALLDATGSytaafLVFAVLALVALVLTLLLYRRPR 387


                  .
gi 2302977120 403 K 403
Cdd:COG2223   388 R 388
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 11-397 5.56e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.83  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  11 IIAAFITAVSLFGDAMLYAVLPVNSEEFGLTaLWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFA 90
Cdd:cd17474     2 YAVFFATLLAVLGVSIVDPILPAIAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  91 YGYFNEFIALLIARCVWGVAWAFIkQAGQLLVVEAVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSeSFDTSSVLIGF 170
Cdd:cd17474    81 CGLSDSFALLLAGRALQGIGAAGL-GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 171 AILSALTFPLLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYvkstLSYwiemrdFSALSLLS 250
Cdd:cd17474   159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAF----LTY------LPFLLELL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 251 SISAATLTGILLTLKLAADPFLGYWVGRFSDIRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTL 330
Cdd:cd17474   229 YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPL 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2302977120 331 LDTDAAQyAADSSNKHYVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLRV 397
Cdd:cd17474   309 LTTLVTE-LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 15-178 9.76e-12

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 66.06  E-value: 9.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAMLYAV----LPVNSEEFGltalwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFA 90
Cdd:cd17384     3 VIVYVALLLDNMLLTVvvpiIPDYLNENV-----RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  91 YGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQPGKLTGL-FNGIAgAGVVIGMVVGSLLSESFDTSSVlig 169
Cdd:cd17384    78 FAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIaLGGLA-LGVLVGPPFGGVMYEFVGKSAP--- 153


                  ....*....
gi 2302977120 170 FAILSALTF 178
Cdd:cd17384   154 FLILAFLAL 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-403 8.12e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.97  E-value: 8.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  10 MIIAAFITAVSLFGDAMLYAVL-PVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVST 88
Cdd:COG2271    11 ILALLFLAYFLNYLDRSNLSVAaPPLQADLGLSA-AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  89 FAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLI 168
Cdd:COG2271    90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKER-GRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 169 GFAILSALTFPLllaiktssrgvvqhvenknskallfmvkdrRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSL 248
Cdd:COG2271   169 ILGLPGLLLALL------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 249 LSSISAATLTGILLTLklaadpflgyWVGRFSDIRQSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVT 328
Cdd:COG2271   219 GLLLSLPFLAGIVGSL----------LGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2302977120 329 TLLdtdAAQYAADSSNKHYVVSSYSMT---VDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVLCGFVLLRVKKRNRK 403
Cdd:COG2271   289 FGL---LWALAAELFPKKARGTASGLVntfGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 25-307 1.27e-08

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 56.41  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  25 AMLYAVLPVNSEEFGLTaLWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIAR 104
Cdd:cd17478    13 GFLPALLPLLIAKLGLS-YAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 105 CVWGVAWAFIKQAGqlLVVEAVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSALTFPLLLAI 184
Cdd:cd17478    92 ALAGIGSAAFHPEG--ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 185 KTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMrdfsalsllssISAATLTGILLTL 264
Cdd:cd17478   170 RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-----------GYSLVFAGLLLSL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2302977120 265 KLAADPFLGYWVGRFSDiRQSRTEWLTGSIMAVGILFVIIAFH 307
Cdd:cd17478   239 FLFAGAIGTLIGGPLSD-RFGRRRVIIASLLLAAPFLLLFLLT 280
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-226 2.10e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAMLYAVLPVNSEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYF 94
Cdd:cd17489     3 LANFFFFLSFYLLLPVLPLYAHDLGGSEA-VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  95 NEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILS 174
Cdd:cd17489    82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR-GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2302977120 175 ALTFPLLLAIKTssRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLF 226
Cdd:cd17489   161 LLALLLVFLVKD--PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAY 210
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-221 2.45e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.63  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   1 MIRSTAEKNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIA 80
Cdd:COG0738     1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSD-AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  81 ICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKqpGKLTGLFNGIAGAGVVIGMVVGSLLSES 160
Cdd:COG0738    80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA--ASRLNLLHAFFSLGALLGPLLGGLLILL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2302977120 161 FDTSSVLIGFAILSALTFPLLLAIKTSSRGVVQHVENKNS---KALLFMVKDRRFIVLLLTGFV 221
Cdd:COG0738   158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAgsaASLKSLLKNPRLLLGGLAIFL 221
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 10-389 2.64e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.25  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  10 MIIAAFITAVSLFgdaMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTF 89
Cdd:cd17324     4 LALAAFAIGTTEY---VIQGLLPDIARDFGVSV-AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  90 AYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIG 169
Cdd:cd17324    80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKR-GRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 170 FAILSALTFPLLLAIKTSSRGVVQhVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVkSTLSYWIEmrdfsalsLL 249
Cdd:cd17324   159 IAVLALLAALLLWRLLPSLPPKKP-GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY-TYLAPFLT--------DV 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 250 SSISAATLTGILLTLKLAAdpFLG-YWVGRFSDIRQSRTeWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVT 328
Cdd:cd17324   229 PGFSSSAIIGLLLLFGVAG--VVGsPLAGRLADRGGRRA-LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2302977120 329 TLLDTDAAQYAADSSNKhyVVSSYSMTVDIGAALGPFLGFTLLSVIGDTFLNVGAALLLVL 389
Cdd:cd17324   306 SALQTRVLRLAPEARGL--ASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-411 1.56e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.98  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  37 EFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNG------LFIAICLTIV-----STFAYGYFNEFIALLIARC 105
Cdd:COG2211    40 VLGLSA-ALVGLILLVARLWDAITDPLIGALSDRTRTRWGrrrpwiLIGAIPLALSfvllfTAPDLSPTGKLIYALVTYL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 106 VWGVAWAFIKQAGQLLVVEAVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL------IGFAILSALTFp 179
Cdd:COG2211   119 LLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrltaLIFAVLGLLAF- 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 180 LLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSLLSSISAATLTG 259
Cdd:COG2211   198 LLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 260 ILLTlklaadPFLGYWVGRFSdirqSRTEWLTGSIMAVGILFVIIAFHLQTVVWLSTLILLLLVSSIVTTLLD----TDA 335
Cdd:COG2211   278 LLGA------PLWPRLAKRFG----KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPwamlADV 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 336 AQYAADSSNKHY---VVSSYSMTVDIGAALGPFLGFTLLSVIGDT--------------FLNVGAALLLVLCGFVLLRVK 398
Cdd:COG2211   348 VDYDEWKTGRRReglYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirLLFFLLPAVLLLLAALLLLFY 427

                         410
                  ....*....|...
gi 2302977120 399 KRNRKNEILIDVD 411
Cdd:COG2211   428 PLTRERHAEIRAE 440
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 10-280 2.24e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.04  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  10 MIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTF 89
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASS-AQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  90 AYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTEsKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIG 169
Cdd:COG0477    95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 170 FAILSALTFPLLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSLL 249
Cdd:COG0477   174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2302977120 250 SSISAATLTGILLTLKLAADPFLGYWVGRFS 280
Cdd:COG0477   254 LALLLLAALLLLLLLLLLLALLLALLLLLLL 284
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 11-396 4.14e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 4.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  11 IIAAFITAVSLFGDAMLYAVLPVNSEEFGLTALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFA 90
Cdd:cd17473     2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  91 YGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSEsfdtssvlIG- 169
Cdd:cd17473    82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEER-AKMLGLQSAAMSLGGVVFLLLGGALAE--------IGw 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 170 ---FAI-LSALTFPLLLAIKTSSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMrdfsa 245
Cdd:cd17473   153 rapFLVyLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQER----- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 246 lsllsSISAATLTGILLTLKLAADPFLGYWVGRFSDIRQSRTEWLTG-SIMAVGILFVIIAFHLQTVVwLSTLILLLLVS 324
Cdd:cd17473   228 -----GGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGfALMALGFLLLALASGLWVVL-LGAILAGLGFG 301

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2302977120 325 SIVTTLLDTDAAQYAADSSNKhyVVSSYSMTVDIGAALGPFLGFTLLSVIGD---TFLNVGAALLLVLCGFVLLR 396
Cdd:cd17473   302 LLLPTLNSWAMSLVPPELRGR--AMGIVTSAFFLGQFLSPLVLGPLVNLTGGlsgAFLILGVLALVLAIVLLLLR 374
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 14-313 1.06e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  14 AFITAVSLFGDAMLYAVLPVNSEEFGLTALWqIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17504     2 ALAALAVMLVETMLSPALPTIQREFGTSAAA-VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIkQAGQLLVVEAVTESKQPGKLtGLFNGIAGAGVVIGMVVGSLLSESFDTSS---VLIGF 170
Cdd:cd17504    81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQ-GILSATFGIGAGIGLPLGGWIVQHLGWRWifwTAAPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 171 AILSALTFPlLLAIKTSSRGVVqhvenknskALLfmvkdrrFIVLLLTGFVISLLFQgyvksTLSYWIEMRdfsalSLLS 250
Cdd:cd17504   159 AVLLAALVP-LIDLRLLRRRNV---------LLA-------NITALLAGFGMFMVFQ-----LLPQLLQLP-----TPTG 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2302977120 251 SISAATLTGILLTLKLAADPFLGYWVGRFSDIRQSRTEWLTGSIMAVgILFVIIAFHLQTVVW 313
Cdd:cd17504   212 FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA-VGLLLLALLHSSLWA 273
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 15-229 1.79e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.45  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAMLYAVLPVNSEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYF 94
Cdd:cd17390     3 LVGFLDLFGVSMILPLLSTHIRSLGASPT-VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  95 NEFIALLIARCVWGVawafIKQA---GQLLVVEAVTESKQPGKLtGLFNGIAGAGVVIGMVVGSLLSESFDtssvliGFA 171
Cdd:cd17390    82 TSLALLFLSRIPLGI----FKHTqslCKAYLSDLVSEQERSRVL-GRFNAASSLGFILGPVVGGHLAETDG------GFY 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 172 ILSALTFPLLLAiktssrgvvqhvenkNSKALLFMVKDRR--FIVLLLTGFVISLLFQGY 229
Cdd:cd17390   151 YVALLCSAIFIL---------------NAGLVWFLLSKLWdlLLVRFLMGFSVLLFRSNF 195
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 8-184 1.92e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.45  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   8 KNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:cd17329   200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVL 167
Cdd:cd17329   280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKR-GSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358

                         170
                  ....*....|....*..
gi 2302977120 168 IGFAILSALTFPLLLAI 184
Cdd:cd17329   359 LILAALGLIAAALLLGL 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
29-226 8.05e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  29 AVLPVNSEEFGLTAlWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWG 108
Cdd:COG2807    39 PLLPEIRADLGLSA-TQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 109 VAWAFikqaGQLLVVEAVTE--SKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSALTFPLLLAIkt 186
Cdd:COG2807   118 AGIAV----GNVLLPGLIKRwfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL-- 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2302977120 187 SSRGVVQHVENKNSKALLFMVKDRRFIVLLLTGFVISLLF 226
Cdd:COG2807   192 LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLY 231
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 15-183 7.58e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAMLYAVLPVNSEEFGLTALWqIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYF 94
Cdd:cd17477     3 LSVALLGLGSGLLLPLLSLRLEREGVSTAL-IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  95 NEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTsSVLIGFAILS 174
Cdd:cd17477    82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR-GRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLLL 159


                  ....*....
gi 2302977120 175 ALTFPLLLA 183
Cdd:cd17477   160 LALVPLLLT 168
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 11-161 9.54e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 9.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  11 IIAAFITAVSLFGDAMLYA-VLPVNSEEFGL-TALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVST 88
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGfVAPVLAAEFSLgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2302977120  89 FAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVtESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESF 161
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFA-PSKRRGFALGLLQSGWALGALLAALVASLLIPLL 152
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 35-313 1.14e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.63  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  35 SEEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFI 114
Cdd:cd17319    30 MKDLGLSPT-QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 115 kQAGQLLVVEAVTESKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSaltfpLLLAIktssrgvvqh 194
Cdd:cd17319   109 -FPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG-----LLLAV---------- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 195 venknskALLFMVkdRRFIVLLLTGFVISLLFQGYVKSTLSYWIEMRDFSALSllssisaatlTGILLTLKLAADPFLGY 274
Cdd:cd17319   173 -------LWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQ----------VGLLAAIPFLAGAIGMI 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2302977120 275 WVGRFSDIRQSRTE-WLTGSIMAVGILFVIIAFHLQTVVW 313
Cdd:cd17319   234 LGGRLSDRLLRGARrLVIIIGLLLAAVGLLLAYLTTSPVV 273
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
36-194 1.41e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.63  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  36 EEFGLTALwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNE-FIALLIARCVWGVAWAFI 114
Cdd:COG2223   234 DQFGLSAA-TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGG 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120 115 KqAGQLLVVEAVTESKQPGKLTGLFNGIAG-AGVVIGMVVGSLLSESFDTSSVLIGFAILSALTFPLLLAIKTSSRGVVQ 193
Cdd:COG2223   313 N-GAVFALVPDIFPTKNAGAVYGLVGAAGGlGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391


                  .
gi 2302977120 194 H 194
Cdd:COG2223   392 A 392
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 62-178 2.21e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  62 PLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESkqPGKLTGLFNG 141
Cdd:cd17324   252 PLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA--RGLASSLYLA 329

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2302977120 142 IAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSALTF 178
Cdd:cd17324   330 AYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 15-128 2.75e-03

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 39.60  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAMLYAVL-PVNSEEFGLTAlwQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17383     2 VIVCIALLLDNMLYMVIvPIIPDYLNEDI--AIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAF 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTE 128
Cdd:cd17383    80 GESYAVLFFARSLQGVGSAFADTAGLAMIADRFTE 114
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 62-181 3.08e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.48  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  62 PLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNG 141
Cdd:cd17503    49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKR-GAAMGLVGL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2302977120 142 IAGAGVVIGMVVGSLLSESFDTSS---VLIGFAILSALTFPLL 181
Cdd:cd17503   128 VILLAPAIGPTLGGWLTDNLSWRWifyINLPIGILALLLAPLL 170
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 15-182 3.25e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  15 FITAVSLFGDAML-YAVLPVNSEEFGLTALWQIGVLLSINrFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGY 93
Cdd:cd17370   205 YLLAVALFALGNFsFAFLILRAQELGLSAALIPLLYALFN-LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  94 FNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQpGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAIL 173
Cdd:cd17370   284 GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR-GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362


                  ....*....
gi 2302977120 174 SALTFPLLL 182
Cdd:cd17370   363 ALIALLLLL 371
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
 65-183 3.59e-03

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 39.28  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  65 GWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQPGKLTGLFNGIaG 144
Cdd:pfam06779  51 AWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGV-G 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2302977120 145 AGVVI-GMVVGSLLSESFDTSSVLIGFAILSALTFPLLLA 183
Cdd:pfam06779 130 IGIALsGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFP 169
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 36-182 4.77e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  36 EEFGLTALWqIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVSTFAYGYFNEFIALLIARCVWGVAWAFIK 115
Cdd:cd17471   228 NELGGSESW-VGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITA 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2302977120 116 QAGQLLVVEAVTesKQPGKLTGLFNGIAGAGVVIGMVVGSLLSESFDTSSVLIGFAILSALTFPLLL 182
Cdd:cd17471   307 GLGISYFQDLMP--GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 8-182 6.86e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120   8 KNMIIAAFITAVSLFGDAMLYAVLPVNSEEFGLTALWQIGVLLSINRFVRIPIHPLIGWFYTRYPVRNGLFIAICLTIVS 87
Cdd:cd06174   203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2302977120  88 TFAYGYFNEFIALLIARCVWGVAWAFIKQAGQLLVVEAVTESKQPGKLTGLFNGIAGAGVVIG-MVVGSLLSESFDTSSV 166
Cdd:cd06174   283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGpLLAGFLLAATFGLTGA 362

                         170
                  ....*....|....*.
gi 2302977120 167 LIGFAILSALTFPLLL 182
Cdd:cd06174   363 FLVLAVLLLLAAILLL 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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