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Conserved domains on  [gi|2305885497|ref|WP_260692221|]
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lytic transglycosylase domain-containing protein [Gemmobacter fulva]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 10083321)

lytic transglycosylase domain-containing protein similar to exolysins that catalyze the cleavage of the host peptidoglycans during virus entry

EC:  4.2.2.n1
Gene Ontology:  GO:0016798
PubMed:  8203016|8692991|7712284

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 99-200 1.53e-38

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


:

Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 128.87  E-value: 1.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  99 AFFQAMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV----DPADPIENLDGGARYLLEQMAAF-GSLELALAAYNAG 173
Cdd:cd00254     2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRrgvdDLFDPEENIRAGARYLRELLDRFgGDLELALAAYNAG 81

                          90       100
                  ....*....|....*....|....*....
gi 2305885497 174 PDAVRKY--DGVPPYAETQSHIVKVMAAY 200
Cdd:cd00254    82 PGAVDRWggGEVPPYKETRNYVQRVLAYY 110
 
Name Accession Description Interval E-value
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 99-200 1.53e-38

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 128.87  E-value: 1.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  99 AFFQAMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV----DPADPIENLDGGARYLLEQMAAF-GSLELALAAYNAG 173
Cdd:cd00254     2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRrgvdDLFDPEENIRAGARYLRELLDRFgGDLELALAAYNAG 81

                          90       100
                  ....*....|....*....|....*....
gi 2305885497 174 PDAVRKY--DGVPPYAETQSHIVKVMAAY 200
Cdd:cd00254    82 PGAVDRWggGEVPPYKETRNYVQRVLAYY 110
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 51-202 1.68e-34

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 122.41  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  51 AEAAADVSHSTKGVAAPRDVLPSIRLIATRYQDHPALARleisptewtaffqAMIKVESNYIHGAVSHAGALGLAQLMPG 130
Cdd:COG0741    84 ALAAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVL-------------ALIRQESAFNPNAVSPAGARGLMQLMPA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 131 TATYLGV---------DPADPIENLDGGARYLLEQMAAF-GSLELALAAYNAGPDAVRKY--------DGVPPYAETQSH 192
Cdd:COG0741   151 TARRLGLklglgpspdDLFDPETNIRAGAAYLRELLDRFdGDLVLALAAYNAGPGRVRRWlrrngdrdGEIIPYAETRNY 230

                         170
                  ....*....|
gi 2305885497 193 IVKVMAAYDR 202
Cdd:COG0741   231 VKKVLANYAI 240
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 86-180 2.97e-18

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 76.58  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  86 ALARLEISPTEwtafFQAMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV-------DPADPIENLDGGARYLLEQMA 158
Cdd:pfam01464   4 AAQKYGVDPSL----LLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLrvnpgvdDLFDPEKNIKAGTKYLKELYK 79

                          90       100
                  ....*....|....*....|...
gi 2305885497 159 AFG-SLELALAAYNAGPDAVRKY 180
Cdd:pfam01464  80 QYGgDLWLALAAYNAGPGRVRKW 102
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 103-201 6.05e-09

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 55.07  E-value: 6.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 103 AMIKVESNYIHGAVSHAGALGLAQLMPGTATYLG--------VDPA---DPIENLDGGARYLLEQMAAFGSLE-LALAAY 170
Cdd:PRK11619  499 AIARQESAWNPKARSPVGASGLMQIMPGTATHTVkmfsipgySSSSqllDPETNINIGTSYLEYVYQQFGNNRiLASAAY 578

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2305885497 171 NAGPDAVRKY--------DGVP-----PYAETQSHiVKVMAAYD 201
Cdd:PRK11619  579 NAGPGRVRTWlgnsagriDAVAfvesiPFSETRGY-VKNVLAYD 621
 
Name Accession Description Interval E-value
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 99-200 1.53e-38

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 128.87  E-value: 1.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  99 AFFQAMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV----DPADPIENLDGGARYLLEQMAAF-GSLELALAAYNAG 173
Cdd:cd00254     2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRrgvdDLFDPEENIRAGARYLRELLDRFgGDLELALAAYNAG 81

                          90       100
                  ....*....|....*....|....*....
gi 2305885497 174 PDAVRKY--DGVPPYAETQSHIVKVMAAY 200
Cdd:cd00254    82 PGAVDRWggGEVPPYKETRNYVQRVLAYY 110
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 51-202 1.68e-34

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 122.41  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  51 AEAAADVSHSTKGVAAPRDVLPSIRLIATRYQDHPALARleisptewtaffqAMIKVESNYIHGAVSHAGALGLAQLMPG 130
Cdd:COG0741    84 ALAAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVL-------------ALIRQESAFNPNAVSPAGARGLMQLMPA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 131 TATYLGV---------DPADPIENLDGGARYLLEQMAAF-GSLELALAAYNAGPDAVRKY--------DGVPPYAETQSH 192
Cdd:COG0741   151 TARRLGLklglgpspdDLFDPETNIRAGAAYLRELLDRFdGDLVLALAAYNAGPGRVRRWlrrngdrdGEIIPYAETRNY 230

                         170
                  ....*....|
gi 2305885497 193 IVKVMAAYDR 202
Cdd:COG0741   231 VKKVLANYAI 240
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 103-202 1.93e-27

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 101.43  E-value: 1.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 103 AMIKVESNYIHGAVSHAGALGLAQLMPGTATY----LGV------DPADPIENLDGGA---RYLLEQMaaFGSLELALAA 169
Cdd:cd16896    24 AVIKVESNFNPNAVSSKGAIGLMQIMPETAEWiaekLGLedfsedDLYDPETNIRLGTwylSYLLKEF--DGNLVLALAA 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2305885497 170 YNAGPDAVRK--------YDGVP----PYAETQSHIVKVMAAYDR 202
Cdd:cd16896   102 YNAGPGNVDKwlkdggwsGDGKTldqiPFPETRHYVKKVLKNYKI 146
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 67-200 1.23e-24

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 94.47  E-value: 1.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  67 PRDVLPSIRLIATRYQDHPALArleisptewtaffQAMIKVESNYIHGAVSHAGALGLAQLMPGTATY----LGVDPA-- 140
Cdd:cd13401     3 PLPYRDLVERAAKKNGLDPALV-------------YAIIRQESAFDPDAVSPAGALGLMQLMPATAKDvakkLGLPYYsp 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2305885497 141 ----DPIENLDGGARYLLEQMAAF-GSLELALAAYNAGPDAVRK----YDGVP--------PYAETQSHIVKVMAAY 200
Cdd:cd13401    70 rdlfDPEYNIRLGSAYLAELLDRFdGNPVLALAAYNAGPGRVRRwlkrRGDLDpdlwietiPFSETRNYVKRVLENY 146
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 103-179 9.38e-20

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 85.88  E-value: 9.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 103 AMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV-DPADPIENLDGGARYLL-------EQMAAFGSLELALAAYNAGP 174
Cdd:COG4623   284 ALAYQESHWNPRARSPTGARGLMQLMPATAKELGVdDRLDPEQSIRAGAKYLRwlydrfpEAIDEPDRWWFALAAYNAGP 363


                  ....*
gi 2305885497 175 DAVRK 179
Cdd:COG4623   364 GHVQD 368
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 107-201 1.77e-19

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 80.25  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 107 VESNYIHGAVSHAGALGLAQLMPGTATYLG--VDPA-----DPIENLDGGARYLLEQMAAFGSLELALAAYNAGPDAVRK 179
Cdd:cd16894    16 VESGFNPDAVSSAGAAGLWQFMPATAREYGlrVDSWvderrDPEKSTRAAARYLKDLYKRFGDWLLALAAYNAGEGRVRR 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2305885497 180 ------YDGVPPY------AETQSHIVKVMAAYD 201
Cdd:cd16894    96 aikragTDKWEDYyrlylpAETRRYVPKFLAAKI 129
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 86-180 2.97e-18

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 76.58  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  86 ALARLEISPTEwtafFQAMIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV-------DPADPIENLDGGARYLLEQMA 158
Cdd:pfam01464   4 AAQKYGVDPSL----LLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLrvnpgvdDLFDPEKNIKAGTKYLKELYK 79

                          90       100
                  ....*....|....*....|...
gi 2305885497 159 AFG-SLELALAAYNAGPDAVRKY 180
Cdd:pfam01464  80 QYGgDLWLALAAYNAGPGRVRKW 102
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 108-179 1.87e-15

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 70.64  E-value: 1.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 108 ESNYIHGAVSHAGALGLAQLMPGTATYLGV-DPADPIENLDGGARYL--LEQMAAFGSLE-----LALAAYNAGPDAVRK 179
Cdd:cd13403    22 ESRFNPNARSPAGARGLMQLMPSTARELGVnDRLDPEQNIHAGAKYLryLRDRFPPDIDEpdrlkFALAAYNAGPGHVRD 101
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 99-176 2.42e-11

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 58.09  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  99 AFFQAMIKVESNYIHGAV-SHAGALGLAQLMPGTATYLGVD--------PADPIENLDGGARYLLEQMAAFGSLE----- 164
Cdd:cd13399     6 GILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWKAYGVDgngdgkadPFNPEDAIASAANYLCRHGWDLNAFLgednf 85

                          90
                  ....*....|..
gi 2305885497 165 LALAAYNAGPDA 176
Cdd:cd13399    86 LALAAYNAGPGA 97
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 72-200 1.04e-10

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 57.95  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497  72 PSIRLIATRYQDHPALarleisptewtafFQAMIKVESNYIHGAVSHAGALGLAQLMPGTAtylGVD-----------PA 140
Cdd:cd16893     1 PIVEKYAKKYGVDPAL-------------ILAIIETESSFNPYAVSHSPAYGLMQIVPSTA---GRDvyrllggkgglPS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 141 -----DPIENLDGGARYL-------LEQMAAFGSLELAL-AAYNAGPDAVRKY-----------------DGV------- 183
Cdd:cd16893    65 ksylfDPENNIDIGTAYLhilqnryLKGIKNPKSREYCAiAAYNGGAGNVLRTfssdrkkaiskinrlspDEVyqhltkk 144

                         170
                  ....*....|....*..
gi 2305885497 184 PPYAETQSHIVKVMAAY 200
Cdd:cd16893   145 LPAAETRNYLKKVLKAK 161
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 103-201 6.05e-09

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 55.07  E-value: 6.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 103 AMIKVESNYIHGAVSHAGALGLAQLMPGTATYLG--------VDPA---DPIENLDGGARYLLEQMAAFGSLE-LALAAY 170
Cdd:PRK11619  499 AIARQESAWNPKARSPVGASGLMQIMPGTATHTVkmfsipgySSSSqllDPETNINIGTSYLEYVYQQFGNNRiLASAAY 578

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2305885497 171 NAGPDAVRKY--------DGVP-----PYAETQSHiVKVMAAYD 201
Cdd:PRK11619  579 NAGPGRVRTWlgnsagriDAVAfvesiPFSETRGY-VKNVLAYD 621
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 102-202 5.69e-06

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 43.67  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 102 QAMIKVESNYIHGAVSHAG----ALGLAQL----MPGTATYlGVDPA----DPIENLDGGARYLLEQMAAFGSLELALAA 169
Cdd:cd13400     9 RAIAKVESGFNPNAINRNKngsyDIGLMQInsiwLPELARY-GITREellnDPCTNIYVGAWILARNIKRYGNTWKAVGA 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2305885497 170 YNAGPDAVRKydgvpPYAEtqshivKVMAAYDR 202
Cdd:cd13400    88 YNSGTPKKND-----KYAR------KVYRIYRR 109
PHA00658 PHA00658
putative lysin
 117-201 1.74e-05

putative lysin


Pssm-ID: 106967 [Multi-domain]  Cd Length: 720  Bit Score: 44.81  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 117 SHAGALGLAQLMPGTA---TYLGVDP-------ADPIENLDGGARYLLEQMAAFG-SLELALAAYNAGPDAVRKY----- 180
Cdd:PHA00658  326 SPKGAVGIAQVMPDTApeaAKLAGLPwdenryrNDAAYNRALGMAYFQKQLRDFGgDLPKAYAAYNAGPGALQSAlkdak 405

                          90       100
                  ....*....|....*....|....*.
gi 2305885497 181 DG-----VPpyAETQSHIVKVMAAYD 201
Cdd:PHA00658  406 DGnwlalLP--KETQDYVVKNMQAYN 429
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
103-177 1.02e-04

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 42.35  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2305885497 103 AMIKVESNYIHGAVSHAGALGLAQLMPGTAtylGVD----------PA-----DPIENLDGGARYL-------LEQMAAF 160
Cdd:PRK11671  212 AIMQTESSFNPYAVSRSDALGLMQVVQHTA---GKDvfrmkgksgqPSrsylfDPANNIDTGTAYLailqnvyLGGITNP 288

                          90
                  ....*....|....*...
gi 2305885497 161 GSLELA-LAAYNAGPDAV 177
Cdd:PRK11671  289 TSRRYAvITAYNGGAGSV 306
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
115-173 3.58e-04

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 40.63  E-value: 3.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2305885497 115 AVSHAGALGLAQLMPGTATYLGV-DPADPIENLDGGARYLLEQMAAF-GSLE------LALAAYNAG 173
Cdd:PRK10859  320 ATSPTGVRGLMMLTRNTAQSMGVtDRLDPEQSIRGGARYLQDLMERLpESIPeperiwFALAAYNIG 386
PHA00368 PHA00368
internal virion protein D
 104-173 5.28e-04

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 40.53  E-value: 5.28e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2305885497  104 MIKVESNYIHGAVSHAGALGLAQLMPGTATYLGV-----DPADPIENLDGGARYLLEQMAAFGSLELALA-AYNAG 173
Cdd:PHA00368    32 VGWDESRFNPTAKSPTGPKGLMQFTKATAKALGLivdddDRLDPELAIDAGARYLADLVGKYDGDELKAAlAYNQG 107
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 103-152 1.05e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 36.23  E-value: 1.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2305885497 103 AMIKVESNYIHGA--VSHAGALGLAQLMPGTATYLGV----DPADPIENLDGGARY 152
Cdd:cd00442     4 AIIGQESGGNKPAnaGSGSGAAGLFQFMPGTWKAYGKnsssDLNDPEASIEAAAKY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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