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Conserved domains on  [gi|2311287820|ref|WP_261971718|]
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FAD-dependent oxidoreductase [Prosthecodimorpha staleyi]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1562436)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyr_redox_2 super family cl39093
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 11-381 5.72e-144

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


The actual alignment was detected with superfamily member TIGR03169:

Pssm-ID: 476868  Cd Length: 364  Bit Score: 412.75  E-value: 5.72e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGMLPGLVAGLYRRDEIHIDLVRLAAATGTRLIHAAADGIDR 90
Cdd:TIGR03169   2 LVLIGGGHSHALVLRMWGMKPLPGVRLTLINPGPTTPYSGMLPGHVAGHYTRDELHIDLVRLARFAGARLILDRAIGLDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  91 AARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIGGFLDRLETLRaEAARAGGRRRIVVVGGGAAGIELI 170
Cdd:TIGR03169  82 AAKQVICAGRPPIAYDVLSIDIGSTPALPDVPGFAEHAIPAKPLGQFAQRWQRFL-ERAKPQQPPRIAVIGGGAAGVELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 171 LALYSRLRADAAAAgrdpdgfAFALVT-GARLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIAAD 249
Cdd:TIGR03169 161 LAMAHRLRQLGRNA-------EVTLIDrGNVLLPGHNARVRRRLERALQERGVTLHLGATVAEVTADAVRLEDGQTLPAD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 250 AVLVSTKARAPAWLAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMVASPREKAGVFAVRQGPILAENLIALAHGT 329
Cdd:TIGR03169 234 FTFWATGARPPGWLAESGLALDEDGFIRVGPTLQSLSHPDIFAAGDCAHLVHAPRPKAGVFAVRQAPVLAENLRAALTGG 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2311287820 330 PLRAYRPQHRFLVLIATGDGRAVGGRGPWpAFEGRWVWAWKDRIDRRFLRTF 381
Cdd:TIGR03169 314 PLRPYRPQSDYLKLISTGDKSAVASRGGL-AFSGAWLWRWKDRIDRKFMDKF 364
 
Name Accession Description Interval E-value
Nterm_to_SelD TIGR03169
pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family ...
 11-381 5.72e-144

pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family include N-terminal sequence regions of (probable) bifunctional proteins whose C-terminal sequences are SelD, or selenide,water dikinase, the selenium donor protein necessary for selenium incorporation into protein (as selenocysteine), tRNA (as 2-selenouridine), or both. However, some members of this family occur in species that do not show selenium incorporation, and the function of this protein family is unknown.


Pssm-ID: 274465  Cd Length: 364  Bit Score: 412.75  E-value: 5.72e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGMLPGLVAGLYRRDEIHIDLVRLAAATGTRLIHAAADGIDR 90
Cdd:TIGR03169   2 LVLIGGGHSHALVLRMWGMKPLPGVRLTLINPGPTTPYSGMLPGHVAGHYTRDELHIDLVRLARFAGARLILDRAIGLDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  91 AARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIGGFLDRLETLRaEAARAGGRRRIVVVGGGAAGIELI 170
Cdd:TIGR03169  82 AAKQVICAGRPPIAYDVLSIDIGSTPALPDVPGFAEHAIPAKPLGQFAQRWQRFL-ERAKPQQPPRIAVIGGGAAGVELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 171 LALYSRLRADAAAAgrdpdgfAFALVT-GARLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIAAD 249
Cdd:TIGR03169 161 LAMAHRLRQLGRNA-------EVTLIDrGNVLLPGHNARVRRRLERALQERGVTLHLGATVAEVTADAVRLEDGQTLPAD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 250 AVLVSTKARAPAWLAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMVASPREKAGVFAVRQGPILAENLIALAHGT 329
Cdd:TIGR03169 234 FTFWATGARPPGWLAESGLALDEDGFIRVGPTLQSLSHPDIFAAGDCAHLVHAPRPKAGVFAVRQAPVLAENLRAALTGG 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2311287820 330 PLRAYRPQHRFLVLIATGDGRAVGGRGPWpAFEGRWVWAWKDRIDRRFLRTF 381
Cdd:TIGR03169 314 PLRPYRPQSDYLKLISTGDKSAVASRGGL-AFSGAWLWRWKDRIDRKFMDKF 364
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
11-381 5.10e-93

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 283.95  E-value: 5.10e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGMLPGLVAGLYRRDEIHIDLVRLAAATGTRLIHAAADGIDR 90
Cdd:COG1252     4 IVIVGGGFAGLEAARRLRKKLGGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  91 AARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIGGFLDRLETLRAEAARAGGRR--RIVVVGGGAAGIE 168
Cdd:COG1252    84 EARTVTLADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAERRRllTIVVVGGGPTGVE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 169 LILALYSRLRADAAAAGRDPDGFAFALVTGA-RLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIA 247
Cdd:COG1252   164 LAGELAELLRKLLRYPGIDPDKVRITLVEAGpRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDGEEIP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 248 ADAVLVSTKARAPAWLAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMV---ASPREKAGVFAVRQGPILAENLIA 324
Cdd:COG1252   244 ADTVIWAAGVKAPPLLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPdpdGKPVPKTAQAAVQQAKVLAKNIAA 323

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2311287820 325 LAHGTPLRAYRPQHrFLVLIATGDGRAVGGRGPWpAFEGRWVWAWKDRIDRRFLRTF 381
Cdd:COG1252   324 LLRGKPLKPFRYRD-KGCLASLGRGAAVADVGGL-KLSGFLAWLLKRAIHLYFLPGF 378
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 11-296 3.55e-12

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 66.57  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAaahRSGIPVTLIARDLDTPYSGMLP--------------GLVAGLYRRDEIHIDLVRlaaaT 76
Cdd:pfam07992   3 VVVIGGGPAGLAAALTLA---QLGGKVTLIEDEGTCPYGGCVLskallgaaeapeiaSLWADLYKRKEEVVKKLN----N 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  77 GTRLIHAA-ADGIDRAARRVHLQ-----GHPPVAYDLLSIDVGITPDLSEMAGADRHAvavkpigGFLDRLETLRAEAAR 150
Cdd:pfam07992  76 GIEVLLGTeVVSIDPGAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNV-------GFLVRTLDSAEALRL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 151 AGGRRRIVVVGGGAAGIELILALYSRLRADAAaagrdpdgfafaLVTGARLVPTLSAGIRRRVARALATRGIAVHGDARV 230
Cdd:pfam07992 149 KLLPKRVVVVGGGYIGVELAAALAKLGKEVTL------------IEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSV 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311287820 231 VAIEPD----RVVTAAGASIAADAVLVSTKARA-PAWLAATGLALAPDGSIAVGPTLQSlTDPAILAAGDC 296
Cdd:pfam07992 217 KEIIGDgdgvEVILKDGTEIDADLVVVAIGRRPnTELLEAAGLELDERGGIVVDEYLRT-SVPGIYAAGDC 286
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
10-297 2.87e-05

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 45.68  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  10 GIVLVGGGHAHVQV--MTRMAAAHrsgIPVTLIARDLDTPYSGmlPGL--VAGLYRRDEihiDLVRLAA---ATGTRLI- 81
Cdd:PRK04965    4 GIVIIGSGFAARQLvkNIRKQDAH---IPITLITADSGDEYNK--PDLshVFSQGQRAD---DLTRQSAgefAEQFNLRl 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  82 --HAAADGIDRAARRVHLQGHPpVAYDLLSIDVGITPDLSEMAGadrHAVAVKpiggfLDRLETLRAEAARAGGRRRIVV 159
Cdd:PRK04965   76 fpHTWVTDIDAEAQVVKSQGNQ-WQYDKLVLATGASAFVPPIPG---RELMLT-----LNSQQEYRAAETQLRDAQRVLV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 160 VGGGAAGIELILALYSrlradaaaagrdpDGFAFALVTGA-RLVPTL-SAGIRRRVARALATRGIAVHGDARVVAIEPD- 236
Cdd:PRK04965  147 VGGGLIGTELAMDLCR-------------AGKAVTLVDNAaSLLASLmPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTd 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2311287820 237 ---RVVTAAGASIAADAVLVSTKARAPAWLA-ATGLALAPdgSIAVGPTLQSlTDPAILAAGDCA 297
Cdd:PRK04965  214 sgiRATLDSGRSIEVDAVIAAAGLRPNTALArRAGLAVNR--GIVVDSYLQT-SAPDIYALGDCA 275
 
Name Accession Description Interval E-value
Nterm_to_SelD TIGR03169
pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family ...
 11-381 5.72e-144

pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family include N-terminal sequence regions of (probable) bifunctional proteins whose C-terminal sequences are SelD, or selenide,water dikinase, the selenium donor protein necessary for selenium incorporation into protein (as selenocysteine), tRNA (as 2-selenouridine), or both. However, some members of this family occur in species that do not show selenium incorporation, and the function of this protein family is unknown.


Pssm-ID: 274465  Cd Length: 364  Bit Score: 412.75  E-value: 5.72e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGMLPGLVAGLYRRDEIHIDLVRLAAATGTRLIHAAADGIDR 90
Cdd:TIGR03169   2 LVLIGGGHSHALVLRMWGMKPLPGVRLTLINPGPTTPYSGMLPGHVAGHYTRDELHIDLVRLARFAGARLILDRAIGLDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  91 AARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIGGFLDRLETLRaEAARAGGRRRIVVVGGGAAGIELI 170
Cdd:TIGR03169  82 AAKQVICAGRPPIAYDVLSIDIGSTPALPDVPGFAEHAIPAKPLGQFAQRWQRFL-ERAKPQQPPRIAVIGGGAAGVELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 171 LALYSRLRADAAAAgrdpdgfAFALVT-GARLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIAAD 249
Cdd:TIGR03169 161 LAMAHRLRQLGRNA-------EVTLIDrGNVLLPGHNARVRRRLERALQERGVTLHLGATVAEVTADAVRLEDGQTLPAD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 250 AVLVSTKARAPAWLAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMVASPREKAGVFAVRQGPILAENLIALAHGT 329
Cdd:TIGR03169 234 FTFWATGARPPGWLAESGLALDEDGFIRVGPTLQSLSHPDIFAAGDCAHLVHAPRPKAGVFAVRQAPVLAENLRAALTGG 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2311287820 330 PLRAYRPQHRFLVLIATGDGRAVGGRGPWpAFEGRWVWAWKDRIDRRFLRTF 381
Cdd:TIGR03169 314 PLRPYRPQSDYLKLISTGDKSAVASRGGL-AFSGAWLWRWKDRIDRKFMDKF 364
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
11-381 5.10e-93

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 283.95  E-value: 5.10e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGMLPGLVAGLYRRDEIHIDLVRLAAATGTRLIHAAADGIDR 90
Cdd:COG1252     4 IVIVGGGFAGLEAARRLRKKLGGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  91 AARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIGGFLDRLETLRAEAARAGGRR--RIVVVGGGAAGIE 168
Cdd:COG1252    84 EARTVTLADGRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAERRRllTIVVVGGGPTGVE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 169 LILALYSRLRADAAAAGRDPDGFAFALVTGA-RLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIA 247
Cdd:COG1252   164 LAGELAELLRKLLRYPGIDPDKVRITLVEAGpRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDGEEIP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 248 ADAVLVSTKARAPAWLAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMV---ASPREKAGVFAVRQGPILAENLIA 324
Cdd:COG1252   244 ADTVIWAAGVKAPPLLADLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVPdpdGKPVPKTAQAAVQQAKVLAKNIAA 323

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2311287820 325 LAHGTPLRAYRPQHrFLVLIATGDGRAVGGRGPWpAFEGRWVWAWKDRIDRRFLRTF 381
Cdd:COG1252   324 LLRGKPLKPFRYRD-KGCLASLGRGAAVADVGGL-KLSGFLAWLLKRAIHLYFLPGF 378
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 37-354 3.97e-21

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 92.95  E-value: 3.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  37 VTLIARDLDTPYS--GMLPGLVAGLYRRDEIHIDLVRLAAATGTRLI-HAAADGIDRAARRVHLQGHPPVAYDLLSIDVG 113
Cdd:COG0446     8 ITVIEKGPHHSYQpcGLPYYVGGGIKDPEDLLVRTPESFERKGIDVRtGTEVTAIDPEAKTVTLRDGETLSYDKLVLATG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 114 ITPDLSEMAGADRHAVavkpigGFLDRLETLRA--EAARAGGRRRIVVVGGGAAGIELILALysrlradaaaagrDPDGF 191
Cdd:COG0446    88 ARPRPPPIPGLDLPGV------FTLRTLDDADAlrEALKEFKGKRAVVIGGGPIGLELAEAL-------------RKRGL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 192 AFALV-TGARLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPD---RVVTAAGASIAADAVLVSTKARAPAWLA-AT 266
Cdd:COG0446   149 KVTLVeRAPRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDGDdkvAVTLTDGEEIPADLVVVAPGVRPNTELAkDA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 267 GLALAPDGSIAVGPTLQSlTDPAILAAGDCAAMVASPREKA-----GVFAVRQGPILAENLIalahGTPLRaYRPQHRF- 340
Cdd:COG0446   229 GLALGERGWIKVDETLQT-SDPDVYAAGDCAEVPHPVTGKTvyiplASAANKQGRVAAENIL----GGPAP-FPGLGTFi 302

                         330
                  ....*....|....*....
gi 2311287820 341 -----LVLIATGDGRAVGG 354
Cdd:COG0446   303 skvfdLCIASTGTGRLLGA 321
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
11-322 1.61e-17

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 83.27  E-value: 1.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGiPVTLIARDLDTPYSG-MLPGLVAGLYRRDEIHIDLVRLAAATGTRLI-HAAADGI 88
Cdd:COG1251     4 IVIIGAGMAGVRAAEELRKLDPDG-EITVIGAEPHPPYNRpPLSKVLAGETDEEDLLLRPADFYEENGIDLRlGTRVTAI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  89 DRAARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVkpiggfLDRLETLRAEAARAGGRRRIVVVGGGAAGIE 168
Cdd:COG1251    83 DRAARTVTLADGETLPYDKLVLATGSRPRVPPIPGADLPGVFT------LRTLDDADALRAALAPGKRVVVIGGGLIGLE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 169 LILALysrlradaaaagrDPDGFAFALV-TGARLVPT-LSAGIRRRVARALATRGIAVHGDARVVAIEPD----RVVTAA 242
Cdd:COG1251   157 AAAAL-------------RKRGLEVTVVeRAPRLLPRqLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDdrvtGVRLAD 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 243 GASIAADAVLVSTKARAP-AWLAATGLALapDGSIAVGPTLQSlTDPAILAAGDCAAMVASPREKAGVF----AVRQGPI 317
Cdd:COG1251   224 GEELPADLVVVAIGVRPNtELARAAGLAV--DRGIVVDDYLRT-SDPDIYAAGDCAEHPGPVYGRRVLElvapAYEQARV 300


                  ....*
gi 2311287820 318 LAENL 322
Cdd:COG1251   301 AAANL 305
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 11-296 3.55e-12

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 66.57  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAaahRSGIPVTLIARDLDTPYSGMLP--------------GLVAGLYRRDEIHIDLVRlaaaT 76
Cdd:pfam07992   3 VVVIGGGPAGLAAALTLA---QLGGKVTLIEDEGTCPYGGCVLskallgaaeapeiaSLWADLYKRKEEVVKKLN----N 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  77 GTRLIHAA-ADGIDRAARRVHLQ-----GHPPVAYDLLSIDVGITPDLSEMAGADRHAvavkpigGFLDRLETLRAEAAR 150
Cdd:pfam07992  76 GIEVLLGTeVVSIDPGAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNV-------GFLVRTLDSAEALRL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 151 AGGRRRIVVVGGGAAGIELILALYSRLRADAAaagrdpdgfafaLVTGARLVPTLSAGIRRRVARALATRGIAVHGDARV 230
Cdd:pfam07992 149 KLLPKRVVVVGGGYIGVELAAALAKLGKEVTL------------IEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSV 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311287820 231 VAIEPD----RVVTAAGASIAADAVLVSTKARA-PAWLAATGLALAPDGSIAVGPTLQSlTDPAILAAGDC 296
Cdd:pfam07992 217 KEIIGDgdgvEVILKDGTEIDADLVVVAIGRRPnTELLEAAGLELDERGGIVVDEYLRT-SVPGIYAAGDC 286
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 155-322 6.49e-09

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 57.40  E-value: 6.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 155 RRIVVVGGGAAGIELilalysrlradaaaagrdpdGFAFA--------LVTGARLVPTLSAGIRRRVARALATRGIAVHG 226
Cdd:COG1249   169 KSLVVIGGGYIGLEF--------------------AQIFArlgsevtlVERGDRLLPGEDPEISEALEKALEKEGIDILT 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 227 DARVVAIEPD----RVVTAAGASIAADA---VLVSTkARAPA----WLAATGLALAPDGSIAVGPTLQSlTDPAILAAGD 295
Cdd:COG1249   229 GAKVTSVEKTgdgvTVTLEDGGGEEAVEadkVLVAT-GRRPNtdglGLEAAGVELDERGGIKVDEYLRT-SVPGIYAIGD 306

                         170       180
                  ....*....|....*....|....*....
gi 2311287820 296 CA--AMVASprekagvFAVRQGPILAENL 322
Cdd:COG1249   307 VTggPQLAH-------VASAEGRVAAENI 328
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
10-297 2.87e-05

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 45.68  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  10 GIVLVGGGHAHVQV--MTRMAAAHrsgIPVTLIARDLDTPYSGmlPGL--VAGLYRRDEihiDLVRLAA---ATGTRLI- 81
Cdd:PRK04965    4 GIVIIGSGFAARQLvkNIRKQDAH---IPITLITADSGDEYNK--PDLshVFSQGQRAD---DLTRQSAgefAEQFNLRl 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  82 --HAAADGIDRAARRVHLQGHPpVAYDLLSIDVGITPDLSEMAGadrHAVAVKpiggfLDRLETLRAEAARAGGRRRIVV 159
Cdd:PRK04965   76 fpHTWVTDIDAEAQVVKSQGNQ-WQYDKLVLATGASAFVPPIPG---RELMLT-----LNSQQEYRAAETQLRDAQRVLV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 160 VGGGAAGIELILALYSrlradaaaagrdpDGFAFALVTGA-RLVPTL-SAGIRRRVARALATRGIAVHGDARVVAIEPD- 236
Cdd:PRK04965  147 VGGGLIGTELAMDLCR-------------AGKAVTLVDNAaSLLASLmPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTd 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2311287820 237 ---RVVTAAGASIAADAVLVSTKARAPAWLA-ATGLALAPdgSIAVGPTLQSlTDPAILAAGDCA 297
Cdd:PRK04965  214 sgiRATLDSGRSIEVDAVIAAAGLRPNTALArRAGLAVNR--GIVVDSYLQT-SAPDIYALGDCA 275
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 80-298 3.93e-05

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 45.88  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  80 LIHAAADGIDRAARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVavkpiggFLDR-LETLRAEAARAGGRRRIV 158
Cdd:PRK14989   77 LVGERAITINRQEKVIHSSAGRTVFYDKLIMATGSYPWIPPIKGSETQDC-------FVYRtIEDLNAIEACARRSKRGA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 159 VVGGGAAGIELILALYSRLRADAAaagrdpdgFAFALVTGA-RLVPTLSAGIRRRVARAlatrGIAVHGDARVVAIEPD- 236
Cdd:PRK14989  150 VVGGGLLGLEAAGALKNLGVETHV--------IEFAPMLMAeQLDQMGGEQLRRKIESM----GVRVHTSKNTLEIVQEg 217

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2311287820 237 -----RVVTAAGASIAADAVLVSTKARAPAWLA-ATGLALAPDGSIAVGPTLQSlTDPAILAAGDCAA 298
Cdd:PRK14989  218 vearkTMRFADGSELEVDFIVFSTGIRPQDKLAtQCGLAVAPRGGIVINDSCQT-SDPDIYAIGECAS 284
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 155-324 7.00e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 44.78  E-value: 7.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 155 RRIVVVGGGAAGIELilalysrlradaaaagrdpdGFAFAL----VT----GARLVPTLSAGIRRRVARALATRgIAVHG 226
Cdd:PRK06292  170 KSLAVIGGGVIGLEL--------------------GQALSRlgvkVTvferGDRILPLEDPEVSKQAQKILSKE-FKIKL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 227 DARVVAIEPDRVVTAAGASIAADA-------VLVSTkARAP----AWLAATGLALAPDGSIAVGPTLQSlTDPAILAAGD 295
Cdd:PRK06292  229 GAKVTSVEKSGDEKVEELEKGGKTetieadyVLVAT-GRRPntdgLGLENTGIELDERGRPVVDEHTQT-SVPGIYAAGD 306

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2311287820 296 CAA--MVASPrekagvfAVRQGPILAENLIA 324
Cdd:PRK06292  307 VNGkpPLLHE-------AADEGRIAAENAAG 330
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 11-311 1.02e-04

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 44.43  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  11 IVLVGGGHAHVQVMTRMAAAHRSGIPVTLIARDLDTPYSGM-LPGLVAGLYRRDEIHI------DLVRLAAATGTRLIHa 83
Cdd:TIGR02374   1 LVLVGNGMAGHRCIEEVLKLNRHMFEITIFGEEPHPNYNRIlLSSVLQGEADLDDITLnskdwyEKHGITLYTGETVIQ- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  84 aadgIDRAARRVHLQGHPPVAYDLLSIDVGITPDLSEMAGADRHAVAVKPIggfLDRLETLRAEAARAggrRRIVVVGGG 163
Cdd:TIGR02374  80 ----IDTDQKQVITDAGRTLSYDKLILATGSYPFILPIPGADKKGVYVFRT---IEDLDAIMAMAQRF---KKAAVIGGG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 164 AAGIELILALysrlradaaaagrDPDGFAFALVT-GARLVP-TLSAGIRRRVARALATRGIAVHGDARVVAI----EPDR 237
Cdd:TIGR02374 150 LLGLEAAVGL-------------QNLGMDVSVIHhAPGLMAkQLDQTAGRLLQRELEQKGLTFLLEKDTVEIvgatKADR 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 238 VVTAAGASIAADAVLVSTKARAPAWLA-ATGLALApdGSIAVGPTLQSlTDPAILAAGDCAA-------MVASPREKAGV 309
Cdd:TIGR02374 217 IRFKDGSSLEADLIVMAAGIRPNDELAvSAGIKVN--RGIIVNDSMQT-SDPDIYAVGECAEhngrvygLVAPLYEQAKV 293


                  ..
gi 2311287820 310 FA 311
Cdd:TIGR02374 294 LA 295
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 46-367 2.41e-03

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 39.75  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820  46 TPysgMLPGLVAGLYRRDEIhIDLVRLAAAT-GTRLIHAAADGIDRAARRV----------HLQGHPPVAYDLLSIDVGI 114
Cdd:PTZ00318   48 TP---LLPQTTTGTLEFRSI-CEPVRPALAKlPNRYLRAVVYDVDFEEKRVkcgvvsksnnANVNTFSVPYDKLVVAHGA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 115 TPDLSEMAGADRHAVAVKPIG-------GFLDRLETLRAEAARAGGRRRI---VVVGGGAAGIELILALYSRLRADAAAA 184
Cdd:PTZ00318  124 RPNTFNIPGVEERAFFLKEVNhargirkRIVQCIERASLPTTSVEERKRLlhfVVVGGGPTGVEFAAELADFFRDDVRNL 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 185 GRDPDGFAFALV--TGARLVPTLSAGIRRRVARALATRGIAVHGDARVVAIEPDRVVTAAGASIAADAVLVSTKARAPAW 262
Cdd:PTZ00318  204 NPELVEECKVTVleAGSEVLGSFDQALRKYGQRRLRRLGVDIRTKTAVKEVLDKEVVLKDGEVIPTGLVVWSTGVGPGPL 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311287820 263 LAATGLALAPDGSIAVGPTLQSLTDPAILAAGDCAAMVASPREKAGVFAVRQGPILAENLIALAHGTPLRayRP-QHRFL 341
Cdd:PTZ00318  284 TKQLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANEERPLPTLAQVASQQGVYLAKEFNNELKGKPMS--KPfVYRSL 361

                         330       340
                  ....*....|....*....|....*....
gi 2311287820 342 VLIA-TGDGRAVGGRGPWP--AFEGRWVW 367
Cdd:PTZ00318  362 GSLAyLGNYSAIVQLGAFDlsGFKALLFW 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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