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Conserved domains on  [gi|2311290376|ref|WP_261974223|]
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nicotinate phosphoribosyltransferase, partial [Exiguobacterium soli]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-296 1.33e-138

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK09243:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 464  Bit Score: 399.92  E-value: 1.33e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:PRK09243  173 AARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKEL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAkGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:PRK09243  253 GD-GIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGV 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGALVPVIKVSSSKAKTTTPHIKEVYRIVDRvTNKFKGDYVTLLDEDPThlDSIDLIDVRDPSFRNRIENFN 240
Cdd:PRK09243  332 YKLVAIEGEGGMIPKIKLSNSPEKVTTPGRKQVYRIYDK-GGKAEADVITLADEEEE--EPLKMFHPVHTYKSKTVKNFD 408

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRL 296
Cdd:PRK09243  409 AEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
 
Name Accession Description Interval E-value
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 1-296 1.33e-138

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 399.92  E-value: 1.33e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:PRK09243  173 AARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKEL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAkGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:PRK09243  253 GD-GIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGV 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGALVPVIKVSSSKAKTTTPHIKEVYRIVDRvTNKFKGDYVTLLDEDPThlDSIDLIDVRDPSFRNRIENFN 240
Cdd:PRK09243  332 YKLVAIEGEGGMIPKIKLSNSPEKVTTPGRKQVYRIYDK-GGKAEADVITLADEEEE--EPLKMFHPVHTYKSKTVKNFD 408

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRL 296
Cdd:PRK09243  409 AEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 1-303 8.43e-123

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 359.08  E-value: 8.43e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLkSGLPNAIIVAKEL 80
Cdd:COG1488   168 AARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPNAIELAKEL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKgHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:COG1488   247 LAR-GGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFV 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGALVPVIKVSSSKAKTTTPHIKEVYRIVDrvTNKFKGDYVTLLDEDPTHLDsidlidvrdpsfrnrienfn 240
Cdd:COG1488   326 YKLVAVEGDGEWRPVIKLSETPGKKSKPGRKQVYRRDE--DGKATADLVALEDEPLPGEP-------------------- 383

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2311290376 241 vERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRLWKLKLDM 303
Cdd:COG1488   384 -EPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 1-296 5.13e-103

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 308.52  E-value: 5.13e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:TIGR01513 164 AARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKGHkLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:TIGR01513 244 GEQGK-VVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGV 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVdgalVPVIKVSSSKAKTTTPHIKEVYRIVDRvTNKFKGDYVTLLDEDPTHLDSIDLIDVRDPsfrnrienfn 240
Cdd:TIGR01513 323 YKLVAYEG----RPVMKLSENPEKSTLPGRKQVFRLYDA-TGKFLGDELTLADEPIEDLNQEKCTPVFAP---------- 387

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRL 296
Cdd:TIGR01513 388 VEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 1-164 1.82e-95

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 285.24  E-value: 1.82e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:cd01570   164 AARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:cd01570   244 GALGYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGV 323


                  ....
gi 2311290376 161 YKLV 164
Cdd:cd01570   324 YKLV 327
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 190-300 2.71e-32

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 115.74  E-value: 2.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 190 IKEVYRIVDRvTNKFKGDYVTLLDED-PTHLDSIDLIDVRDPSFRNRIENFNVERLLTPVFVDGELIYSVPTIEESRQFH 268
Cdd:pfam17956   1 RKQVYRLYDK-DGKAIADLITLADEPpPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2311290376 269 EQQIGRLWEEYKRLRLPEVYAITFSDRLWKLK 300
Cdd:pfam17956  80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQLK 111
 
Name Accession Description Interval E-value
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 1-296 1.33e-138

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 399.92  E-value: 1.33e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:PRK09243  173 AARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKEL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAkGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:PRK09243  253 GD-GIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGV 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGALVPVIKVSSSKAKTTTPHIKEVYRIVDRvTNKFKGDYVTLLDEDPThlDSIDLIDVRDPSFRNRIENFN 240
Cdd:PRK09243  332 YKLVAIEGEGGMIPKIKLSNSPEKVTTPGRKQVYRIYDK-GGKAEADVITLADEEEE--EPLKMFHPVHTYKSKTVKNFD 408

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRL 296
Cdd:PRK09243  409 AEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 1-303 8.43e-123

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 359.08  E-value: 8.43e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLkSGLPNAIIVAKEL 80
Cdd:COG1488   168 AARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPNAIELAKEL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKgHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:COG1488   247 LAR-GGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFV 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGALVPVIKVSSSKAKTTTPHIKEVYRIVDrvTNKFKGDYVTLLDEDPTHLDsidlidvrdpsfrnrienfn 240
Cdd:COG1488   326 YKLVAVEGDGEWRPVIKLSETPGKKSKPGRKQVYRRDE--DGKATADLVALEDEPLPGEP-------------------- 383

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2311290376 241 vERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRLWKLKLDM 303
Cdd:COG1488   384 -EPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 1-296 5.13e-103

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 308.52  E-value: 5.13e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:TIGR01513 164 AARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKGHkLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:TIGR01513 244 GEQGK-VVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGV 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVdgalVPVIKVSSSKAKTTTPHIKEVYRIVDRvTNKFKGDYVTLLDEDPTHLDSIDLIDVRDPsfrnrienfn 240
Cdd:TIGR01513 323 YKLVAYEG----RPVMKLSENPEKSTLPGRKQVFRLYDA-TGKFLGDELTLADEPIEDLNQEKCTPVFAP---------- 387

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRL 296
Cdd:TIGR01513 388 VEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 1-164 1.82e-95

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 285.24  E-value: 1.82e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKEL 80
Cdd:cd01570   164 AARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAKGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:cd01570   244 GALGYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGV 323


                  ....
gi 2311290376 161 YKLV 164
Cdd:cd01570   324 YKLV 327
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 1-304 3.83e-88

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 270.46  E-value: 3.83e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQATLLVDTYDTLKsGLPNAIIVAKEL 80
Cdd:PRK12484  167 VARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKEL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAkGHKLRGIRIDSGDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMV 160
Cdd:PRK12484  246 GN-RFDPRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSA 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 161 YKLVAREVDGalvpviKVSSSKAKTTTPHIKEVYRIVDRVTnkFKGDYVTLLDEDPTHldsidlidvrdpsfrnrienfN 240
Cdd:PRK12484  325 YKLVAYEGRG------VTKLSSGKVTYPGRKQVFRLYEHGT--ACGDVIGLHTENIPD---------------------G 375

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2311290376 241 VERLLTPVFVDGELIYSVPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRLWKLKLDMI 304
Cdd:PRK12484  376 REPLLVPVMTNGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADT 439
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 2-297 3.42e-55

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 187.56  E-value: 3.42e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   2 TRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFH------------------------------------------- 38
Cdd:PLN02885  180 SKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYmgldeivdktlrsadgssvcedfvslvqewlsklqessslrgv 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  39 -----DDELTAFRTFAAYYPDQATLLVDTYDTLKSGLPNAIIVAKELAAKGHKLRGIRIDSGDLSYLSKRARTMLDE--- 110
Cdd:PLN02885  260 fsetnQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEARKFFRTiee 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 111 ----AGFPEVDIVLSGDLDEYVIQDLRIQGAQANTFLVGTRGITAYEQPALGMVYKLVarEVDGAlvPVIKVSSSKAKTT 186
Cdd:PLN02885  340 elgvPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLV--EINGQ--PRIKLSEDVEKVT 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 187 TPHIKEVYRIVDRvtnkfKG----DYVTLLDEDPTHLDsiDLIDVRDP---SFRNRIENFNVERLLTPVF--VDGELIYS 257
Cdd:PLN02885  416 IPCKKRCYRLYGK-----EGyplvDLMTGENEPPPKVG--ERILCRHPfneSKRAYVVPQRVEELLKCYWdgSSGKPREE 488

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2311290376 258 VPTIEESRQFHEQQIGRLWEEYKRLRLPEVYAITFSDRLW 297
Cdd:PLN02885  489 LPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKLY 528
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 1-162 7.32e-47

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 160.90  E-value: 7.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFH-DDELTAFRTFAAYYP----DQATLLVDTYDTLKsGLPNAII 75
Cdd:cd01567   175 GGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFgALEEAAFEAFARWLPqfggGLGIALIDTYDTDN-GFLNALK 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  76 VAKELAAkGHKLRGIRIDSGDLSYLSKRARTMLDEAGF--PEVDIVLSGDLD-EYVIQDLRIQGAQAN-TFLVGTRGITA 151
Cdd:cd01567   254 LAKALGA-GGGLLGVRLDSGDPVELIKKVRKHLDELGIdlNKKKIIISGDLDtEEAIELLLEQGASPNdAFGVGTSLTND 332

                         170
                  ....*....|.
gi 2311290376 152 YEQPALGMVYK 162
Cdd:cd01567   333 LGRPPLGFVYK 343
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 190-300 2.71e-32

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 115.74  E-value: 2.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376 190 IKEVYRIVDRvTNKFKGDYVTLLDED-PTHLDSIDLIDVRDPSFRNRIENFNVERLLTPVFVDGELIYSVPTIEESRQFH 268
Cdd:pfam17956   1 RKQVYRLYDK-DGKAIADLITLADEPpPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2311290376 269 EQQIGRLWEEYKRLRLPEVYAITFSDRLWKLK 300
Cdd:pfam17956  80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQLK 111
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 1-162 7.30e-29

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 111.95  E-value: 7.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   1 GTRASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDdELTAFRTFAAYYPDQATLLVDTYDTLksgLPNAIIVAKEL 80
Cdd:cd00516   129 EKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAFG-ELAAVKALRRWLPELFIALIDVEVDT---LEEALEAAKAG 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  81 AAkghklRGIRIDSG-----DLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGaqANTFLVGTRGITAyeqP 155
Cdd:cd00516   205 GA-----DGIRLDSGspeelDPAVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---P 274


                  ....*..
gi 2311290376 156 ALGMVYK 162
Cdd:cd00516   275 PLDIVLK 281
NAPRTase_B cd01571
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ...
 3-146 1.12e-17

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238805 [Multi-domain]  Cd Length: 302  Bit Score: 81.55  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   3 RASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQ-FHDDELTAFRTFAAYYPDQA--TLLVDTYDTLKSGlpnAIIVAKE 79
Cdd:cd01571   131 RAAYIGGCDGVSTVLGAELLGEKPSGTMPHALIQiFGGDQVEAWKAFDETYPEDVprIALIDTFNDEKEE---ALKAAKA 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2311290376  80 LaakGHKLRGIRIDS-----GDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRIQGAQAntFLVGT 146
Cdd:cd01571   208 L---GDKLDGVRLDTpssrrGVFRYLIREVRWALDIRGYKHVKIFVSGGLDEEDIKELEDVGVDA--FGVGT 274
PRK08662 PRK08662
nicotinate phosphoribosyltransferase; Reviewed
 3-146 1.59e-14

nicotinate phosphoribosyltransferase; Reviewed


Pssm-ID: 236328 [Multi-domain]  Cd Length: 343  Bit Score: 72.99  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   3 RASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHDDELTAFRTFAAYYPDQA--TLLVDTYDTLKSglpNAIIVAKEL 80
Cdd:PRK08662  148 RAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVprIALVDTFKDERE---EALRAAEAL 224

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311290376  81 aakGHKLRGIRIDS-----GDLSYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLRiqgAQANTFLVGT 146
Cdd:PRK08662  225 ---GDRLDGVRLDTpssrrGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIRELR---DVVDGFGVGT 289
PRK07188 PRK07188
nicotinate phosphoribosyltransferase; Provisional
 4-146 1.45e-08

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235953 [Multi-domain]  Cd Length: 352  Bit Score: 55.34  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376   4 ASYLAGFDVTSLASAGRDFGIPCGGTMEHADIQFHD-DELTAFRTFAAYYP-DQATLLVDtY------DTLKsglpnaii 75
Cdd:PRK07188  151 AAYIGGISAFSTHAQNEWWGKSGFGTMPHALIQMFNgDVVEACKAYHKTFPeDELIALVD-YnndvitDSLK-------- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311290376  76 VAKELaakGHKLRGIRID-SGDL---------------------SYLSKRARTMLDEAGFPEVDIVLSGDLDEYVIQDLR 133
Cdd:PRK07188  222 VAREF---GDKLKGVRVDtSKNMidkyfirhpevlgtfdprgvnPELIKALRKALDENGGKHVKIIVSSGFDAKKIREFE 298

                         170
                  ....*....|...
gi 2311290376 134 IQGAQANTFLVGT 146
Cdd:PRK07188  299 AQNVPVDIYGVGS 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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