NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2311975249|ref|WP_262265073|]
View 

tautomerase family protein [Pantoea dispersa]

Protein Classification

tautomerase family protein( domain architecture ID 1755)

tautomerase family protein similar to Homo sapiens macrophage migration inhibitory factor and D-dopachrome decarboxylase-like protein

CATH:  3.30.429.10
Gene Ontology:  GO:0006725|GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 67-127 6.18e-07

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member cd00491:

Pssm-ID: 444774  Cd Length: 58  Bit Score: 43.92  E-value: 6.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311975249  67 PVVslQIYVIKGGLDEDaKKKLIEGATAILdRRPSGTSVAPVYVVIHEVEEANWGIFGQQA 127
Cdd:cd00491     1 PFV--QIYILEGRTDEQ-KRELIERVTEAV-SEILGAPEATIVVIIDEMPKENWGIGGESA 57
 
Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 67-127 6.18e-07

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 43.92  E-value: 6.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311975249  67 PVVslQIYVIKGGLDEDaKKKLIEGATAILdRRPSGTSVAPVYVVIHEVEEANWGIFGQQA 127
Cdd:cd00491     1 PFV--QIYILEGRTDEQ-KRELIERVTEAV-SEILGAPEATIVVIIDEMPKENWGIGGESA 57
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 67-128 3.20e-06

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 42.06  E-value: 3.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2311975249  67 PVVslQIYVIKGgLDEDAKKKLIEGATAILDRRPsGTSVAPVYVVIHEVEEANWGIFGQQAD 128
Cdd:COG1942     1 PII--NIKLFEG-RTPEQKRALAKAVTDAVVEVL-GKPPESVSVVIEEVPPENWGIGGKLLS 58
taut TIGR00013
4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in ...
 71-127 9.80e-06

4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in which each monomer is very small, at about 62 amino acids. Pro-1 of the mature protein serves as a general base. The enzyme functions in meta-cleavage pathways of aromatic hydrocarbon catabolism. Because several Arg residues located near the active site in the crystal structure of Pseudomonas putida are not conserved among all members of this family, because the literature describes a general role in the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers, and because of the presence of fairly distantly related paralogs in Campylobacter jejuni, the family is regarded as not necessarily uniform in function. [Energy metabolism, Other]


Pssm-ID: 129125  Cd Length: 63  Bit Score: 40.87  E-value: 9.80e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2311975249  71 LQIYVIKGGLDEDAKKKLIEGATAILdRRPSGTSVAPVYVVIHEVEEANWGIFGQQA 127
Cdd:TIGR00013   3 VNIYILKEGRTDEQKRQLIEGVTEAM-AETLGANLESIVVIIDEMPKNNYGIGGELV 58
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 71-124 2.84e-05

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 39.58  E-value: 2.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2311975249  71 LQIYVIKGGlDEDAKKKLIEGATAILDRRpSGTSVAPVYVVIHEVEEANWGIFG 124
Cdd:pfam01361   3 VNIKLFEGR-TDEQKKELIERVTDALVEV-LGAPRSAIVVIIEEVPPENWGVGG 54
 
Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 67-127 6.18e-07

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 43.92  E-value: 6.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311975249  67 PVVslQIYVIKGGLDEDaKKKLIEGATAILdRRPSGTSVAPVYVVIHEVEEANWGIFGQQA 127
Cdd:cd00491     1 PFV--QIYILEGRTDEQ-KRELIERVTEAV-SEILGAPEATIVVIIDEMPKENWGIGGESA 57
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 67-128 3.20e-06

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 42.06  E-value: 3.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2311975249  67 PVVslQIYVIKGgLDEDAKKKLIEGATAILDRRPsGTSVAPVYVVIHEVEEANWGIFGQQAD 128
Cdd:COG1942     1 PII--NIKLFEG-RTPEQKRALAKAVTDAVVEVL-GKPPESVSVVIEEVPPENWGIGGKLLS 58
taut TIGR00013
4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in ...
 71-127 9.80e-06

4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in which each monomer is very small, at about 62 amino acids. Pro-1 of the mature protein serves as a general base. The enzyme functions in meta-cleavage pathways of aromatic hydrocarbon catabolism. Because several Arg residues located near the active site in the crystal structure of Pseudomonas putida are not conserved among all members of this family, because the literature describes a general role in the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers, and because of the presence of fairly distantly related paralogs in Campylobacter jejuni, the family is regarded as not necessarily uniform in function. [Energy metabolism, Other]


Pssm-ID: 129125  Cd Length: 63  Bit Score: 40.87  E-value: 9.80e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2311975249  71 LQIYVIKGGLDEDAKKKLIEGATAILdRRPSGTSVAPVYVVIHEVEEANWGIFGQQA 127
Cdd:TIGR00013   3 VNIYILKEGRTDEQKRQLIEGVTEAM-AETLGANLESIVVIIDEMPKNNYGIGGELV 58
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 71-124 2.84e-05

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 39.58  E-value: 2.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2311975249  71 LQIYVIKGGlDEDAKKKLIEGATAILDRRpSGTSVAPVYVVIHEVEEANWGIFG 124
Cdd:pfam01361   3 VNIKLFEGR-TDEQKKELIERVTDALVEV-LGAPRSAIVVIIEEVPPENWGVGG 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH