|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-383 |
7.12e-87 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 268.74 E-value: 7.12e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIW 94
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 95 GFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPP-HLQGVAMGIAGAGNSGTLISTLFGPRLAEI-------YGWH 166
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKeKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 167 AVMGLALIPLSLVFLFFIFTAKDAPNQPAPQPIRS--YFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSK 244
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLkvQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 245 IHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLP-----ALPVVIALLFVGMMCLGMGNGAV 319
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLptsgtNLVLFLALFVALGLGAGAGNGSV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2410419435 320 FQLVPQVFHKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFltiSLFVLIVFLCLVV 383
Cdd:cd17341 321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAF---SLFGVLAVACTLL 381
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
13-335 |
1.51e-86 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 266.86 E-value: 1.51e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 13 KTLFGSFLYFDVSFMIWVLLGALGAF-IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIP 91
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 92 LIWGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGI-AGAGNSGTLISTLFGPRLAE--------- 161
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLaAGWGNMGGGVAQFVMPPIIGslifgggqp 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 162 ---IYGWHAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQP--IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFF 236
Cdd:TIGR00886 161 ahlAWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGKlsFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 237 VDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCL---- 312
Cdd:TIGR00886 241 KDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALfffa 320
|
330 340
....*....|....*....|...
gi 2410419435 313 GMGNGAVFQLVPQVFHKEIGIVT 335
Cdd:TIGR00886 321 GAGNGSTFALVPHIFRRATGAVS 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-391 |
1.50e-78 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 247.49 E-value: 1.50e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 9 SGHPKTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLT 88
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 89 TIPLIWGFIAgTTLSELVLIGILLGV-AGASFAVALPMASRWYPPHLQGVAMGI-AGAGNSGTLISTLFGPRLAEIYGWH 166
Cdd:COG2223 81 GIGLLLLALA-VSYWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLaAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 167 AVMGLALIPLSLVFLFFIFTAKDAP---NQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVS 243
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPagaAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 244 KIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPA-LPVVIALLFVGMMCLGMGNGAVFQL 322
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 323 VPQVF-HKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVVSQIKRKKV 391
Cdd:COG2223 320 VPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-379 |
2.51e-28 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 114.26 E-value: 2.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 32 LGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLiwgFIAGTTLSELVLIGIL 111
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA---LLMALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 112 LgVAGASFAVALPMASR----WYPPHLQGVAMGIAGAG-NSGTLISTLFGPRLAEIYGWHAVM---GLALIPLSLVFLFF 183
Cdd:cd17475 92 F-LVGAGYGSVQPGGGRaimrWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFvvaGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 184 IFTAKDAPNQP--APQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFF 261
Cdd:cd17475 171 YREPPAASAATesASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 262 RPVGGLIADKIGG---MKVLLGLFGIIGICLGGVSSL----PALPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKEIGIV 334
Cdd:cd17475 251 RIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLspgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2410419435 335 TGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFL 379
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-331 |
8.57e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.37 E-value: 8.57e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLS 103
Cdd:COG2814 21 LSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA-PSLW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 104 ELVLIGILLGVAGASF-AVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFL 181
Cdd:COG2814 100 LLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGlGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 182 FFIFTAKDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFF 261
Cdd:COG2814 180 LLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 262 RPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKEI 331
Cdd:COG2814 260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-390 |
9.78e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.57 E-value: 9.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 13 KTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPL 92
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 93 IWGFIAgTTLSELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMG 170
Cdd:COG2271 90 LLFGFA-TSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPlGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 171 LALIPLSLVFLFfiftakdapnqpapqpirsyfsvfqvkSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDF 250
Cdd:COG2271 169 ILGLPGLLLALL---------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 251 VTLCVAAGSFFRPVGGLIADKIG--GMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFH 328
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2410419435 329 KEI-GIVTGIVGAAGGIGGFFLPNILGSLKELTGsYTFGFLTISLFVLIVFLCLVVSQIKRKK 390
Cdd:COG2271 302 KKArGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
29-380 |
2.04e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 100.72 E-value: 2.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 29 WVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTLSeLVLI 108
Cdd:COG2807 34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVAL-LLAG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 109 GILLGVAGASFAVALP-MASRWYPPHLqGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMG-LALIPLSLVFLFFIF 185
Cdd:COG2807 113 TALIGAGIAVGNVLLPgLIKRWFPDRV-GLMTGLYTAAMGlGAALAAGLTVPLAAALGWRGALAvWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 186 TAKDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQyGVSKIHAGDFVTLCVAAGSFFRPVG 265
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 266 GLIADKIGGMKVLLGLFGIIGIClgGVSSLPALPVviALLFVGMMCLGMGNGAVFQLVPQVF------HKEIGIVTGIVG 339
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLA--GLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLALTLIglrartPAEAAALSGMAQ 346
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2410419435 340 AAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLC 380
Cdd:COG2807 347 SVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-383 |
3.87e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 93.79 E-value: 3.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 32 LGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTavigmlLTTIPLIWGFIAG-----TTLSELV 106
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKV------LAVSMLLWSLFTAltgfaTSLTSLY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 107 LIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAV---MGLALIPLSLVFL 181
Cdd:cd17319 96 VLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGWLLLLFGWRWAfiiEGLLGLLLAVLWW 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 182 FFiftakdapnqpapqpirsyfsvfqVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFF 261
Cdd:cd17319 176 FY------------------------LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 262 RPVGGLIADKIGGMK-----VLLGLFGIIGICLGGVSSLPAlpVVIALLFVGMMCLGMGNGAVFQLVPQVFHKE-IGIVT 335
Cdd:cd17319 232 MILGGRLSDRLLRGArrlviIIGLLLAAVGLLLAYLTTSPV--VAVILLSLAGFGIGAASPVFWSLPADLLPGEaAATAG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2410419435 336 GIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVV 383
Cdd:cd17319 310 GLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-323 |
1.95e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 1.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 18 SFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFI 97
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 98 AGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPL 176
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGlGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 177 SLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQV-----KSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFV 251
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAwkallRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2410419435 252 TLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVsSLPALPVVIALLFVGMMCLGMGNGAVFQLV 323
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL-LLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-330 |
1.60e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 1.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 38 FIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTLSELVLIGILLGVAGA 117
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL-LFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 118 SF-AVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFTAKDAPNQPA 195
Cdd:cd17325 100 AVwPAAMALIADIAPPEERGRAMGIFSSAIGlGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 196 PQPIRS------YFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIA 269
Cdd:cd17325 180 KRAVSAarlrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2410419435 270 DKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKE 330
Cdd:cd17325 260 DRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-319 |
1.80e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 89.15 E-value: 1.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTLSeLVLIGILLGVAGAS 118
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL-LLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 119 F-AVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVM-GLALIPLSLVFLFFIFTAKDAPNQPA 195
Cdd:cd17324 104 FwAIAAAYAADLVPPEKRGRAIGLVFSGLTlGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 196 P-QPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGG 274
Cdd:cd17324 184 SlGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2410419435 275 MKVLLGLFGIIGICLGgvssLPALPVVIALLFVGMMCLGMGNGAV 319
Cdd:cd17324 264 RALLIALLLLAAALLL----LTLLGPSPLLLLVGLVLWGLGFFAA 304
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-390 |
6.77e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.44 E-value: 6.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 13 KTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPL 92
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 93 IwGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRL------AEIYGW 165
Cdd:COG0738 88 L-LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSlGALLGPLLGGLLillglsLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 166 HAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKI 245
Cdd:COG0738 167 YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 246 HAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQ 325
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2410419435 326 VFHKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVVSQIKRKK 390
Cdd:COG0738 327 GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
24-329 |
6.20e-16 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 79.16 E-value: 6.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVLLGALGAFIAQ-DFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIA---- 98
Cdd:PRK15034 45 LAFCVWMLFSAVTVNLNKiGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCVWLGIAvqnp 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 99 GTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGI-AGAGNSGTLISTLFGPRL--AEIYGWHAVMGL---- 171
Cdd:PRK15034 125 NTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGInGGLGNLGVSVMQLVAPLVifVPVFAFLGVNGVpqad 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 172 ---------ALIPLSLVFLFFI---FTAKDAPNQPApqPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQ 239
Cdd:PRK15034 205 gsvmslanaAWIWVPLLAIATIaawSGMNDIASSRA--SIADQLPVLQRLHLWLLSLLYLATFGSFIGFSAGFAMLAKTQ 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 240 Y-GVSKIHAGDFVTLCvaaGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLG---------GVSSLPALPVVIALLFvgm 309
Cdd:PRK15034 283 FpDVNILRLAFFGPFI---GAIARSVGGAISDKFGGVRVTLINFIFMAIFSAllfltlpgtGSGNFIAFYAVFMGLF--- 356
|
330 340
....*....|....*....|
gi 2410419435 310 MCLGMGNGAVFQLVPQVFHK 329
Cdd:PRK15034 357 LTAGLGSGSTFQMIAVIFRQ 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-382 |
4.26e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.93 E-value: 4.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 19 FLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIpLIWGFIA 98
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL-GALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 99 GTTLSELVLIGILLGVAGASFAVALP-MASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEI--YGWHAVMGLALI 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLaLIADLFPERERGRALGLLQAFGSvGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 175 PLSLVFLFFIFTAKDAPNQPAPQP--------IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIH 246
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNeeassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 247 AGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGII-GICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQ 325
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 326 VFHKEI-GIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLV 382
Cdd:cd06174 321 LFPPEIrGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
39-324 |
2.32e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 73.80 E-value: 2.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTLSELVLIGILLGV-AGA 117
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIgAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 118 SFAVALPMASRWYPPHLqGVAMGI--AGAGNSGTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIF---------- 185
Cdd:cd17353 109 GYITPVSTAVKWFPDKR-GLATGIviAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLirdppkgwvp 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 186 TAKDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGL--SSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRP 263
Cdd:cd17353 188 PGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLmlIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRP 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2410419435 264 VGGLIADKIGGMKVLLGLFGIIGICLGGvssLPALPVVIALLFVGMMCLGMGNGAVFQLVP 324
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVAMFL---LPFIGSVAVLFVLGVALIGFCYGGGFALFP 325
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
39-331 |
7.50e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 7.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTiplIWGFIAGTTLS--ELVLIGILLGVAG 116
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG---IGGLLCGLSDSfaLLLAGRALQGIGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 117 ASF-AVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEI-YGWHAVMGLALIPLSLVFLFFIFTAKDAPNQ 193
Cdd:cd17474 102 AGLgPLALTLIGDLFEGGERAKAMGLYEAALGlGIAVGPLLGGLLAAIsWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 194 PAPQP-IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFV---TLCVAAGSFFrpVGGLIA 269
Cdd:cd17474 182 SSSATkLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFagwSVLLALGSLF--VGRLLK 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2410419435 270 DKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKEI 331
Cdd:cd17474 260 KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEE 321
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
51-322 |
9.05e-12 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 66.09 E-value: 9.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 51 GMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWY 130
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 131 PPHLQGVAMG-IAGAGNSGTLISTLFGPRLAEIYGWHAVMGLALIP--LSLVFLFFIFTaKDAPNQPAPQPIRSYFSVFQ 207
Cdd:cd17490 114 PPDEAAKAMGlINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAgvLGFILSLFIKE-ERREKKPVLTELKELLSVLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 208 VKSTWFFCLLYAITFG-GFVGLSSFLSIfFVDQYGVSKIHAG---DFVTLCVAAGSFFrpVGGLIADKIGGMKVLLGLFG 283
Cdd:cd17490 193 DKKLLFFSLLAILQQMiTFSTTFGFTPL-IAKQLGASSFQLGllsIIYLLPNALASLL--SGTLFYKKLGERNTIIIGFL 269
|
250 260 270
....*....|....*....|....*....|....*....
gi 2410419435 284 IIGICLGGVSSLPALPvviaLLFVGMMCLGMGNGAVFQL 322
Cdd:cd17490 270 LLGAYCFLIPFAPNLT----LLYLLQALNGFGTGILFPL 304
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-310 |
2.38e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 64.50 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 31 LLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTtlseLVLIGI 110
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN----YWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 111 LLGVAGASFAVALPMASRW---YPPHLQGVAMGIAGA-GNSGTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFT 186
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLasqAAGGRRGLAMSIFSVgGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 187 AKD----APNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFgGFVGLSSFLSIFFVdQYGVSKIHAGDFVTLCVAAGSFFR 262
Cdd:cd17478 170 RPLkkpeAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW-VLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2410419435 263 PVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMM 310
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-385 |
2.68e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.52 E-value: 2.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 34 ALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLSELVLIGILLG 113
Cdd:cd17473 21 ALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL-DSLYALLASRALLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 114 VA-GASFAVALPMASRWYPPHLQGVAMGIAGA-GNSGTLISTLFGPRLAEIyGWHAVMGLALIPLSLVFLFFIF-TAKDA 190
Cdd:cd17473 100 IGvAGIMTLATALIGDYFEGEERAKMLGLQSAaMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFlPEPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 191 PNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGdfvtLCVAAGSFFRPVGGL--- 267
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIG----LALAIASLAGAIGALlfg 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 268 -IADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKEI-GIVTGIVGAAGGIG 345
Cdd:cd17473 255 rLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELrGRAMGIVTSAFFLG 334
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2410419435 346 GFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVVSQ 385
Cdd:cd17473 335 QFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-323 |
4.92e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 63.75 E-value: 4.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVLLGALGAfIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLS 103
Cdd:cd17504 8 VMLVETMLSPALPT-IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA-PNLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 104 ELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLAlIPLSLVFLF 182
Cdd:cd17504 86 VLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTA-APVAVLLAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 183 FIftakdapnqpapqPIRSyFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQ----YGVSKIHAGDFVTLCVAAG 258
Cdd:cd17504 165 LV-------------PLID-LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVM 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2410419435 259 SFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGV----SSLPALPVVIALLFVGMmclGMGNGAVFQLV 323
Cdd:cd17504 231 LIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLallhSSLWALVVALLLIGIGL---GLAFASLPNIV 296
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-320 |
1.16e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.61 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTLS 103
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL-LYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 104 ELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFL 181
Cdd:cd17489 86 LLLVLRLIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTlAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 182 FFIFTAKDAPNQPAPQPI-RSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVskiHAGDFVTLCVAAGSF 260
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAgTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAIALLL 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2410419435 261 FRPVGGLIADKIGGMKVLL--GLFGIIGICLGGVSSLPALPVVIALLFvgmmclGMGNGAVF 320
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIpgLLLLALGLLLLSFAGSPWMLLLAAVLY------GLGFGLLF 298
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-382 |
1.25e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.23 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGALGAFIAQDF--ALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPL 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 93 IWGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGAGNS-----GTLISTLFGPRLAEIYGWHA 167
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgallAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 168 VMGLALIPLSLVFLFFiftakdapnqpapqpirsyfsvfqvKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHA 247
Cdd:cd17316 161 LFLIGALPALLALLLR-------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 248 GDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPV--VIALLFVGMMCLGMGNGAVFQLVPQ 325
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAE 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 326 VFHKEI-GIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLV 382
Cdd:cd17316 296 LFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
24-323 |
2.04e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.81 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVLLGALGAfIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLS 103
Cdd:cd17321 8 AALDVTIVNVALPT-IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA-PSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 104 ELVLIGILLGVAGAS-FAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLaLIPLSLVFL 181
Cdd:cd17321 86 FLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAVVGiGAALGPLLGGLLLELFGWRWIFLI-NVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 182 FFIftakdapnqpapqpirsyfsvfqvKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFF 261
Cdd:cd17321 165 LLA------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2410419435 262 RPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLfVGMMCLGMGNGAVFQLV 323
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLL-PGLVLLGLGLGLFATPL 281
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
26-383 |
2.07e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.90 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 26 FMIWVLLGALGAFIA---QDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTL 102
Cdd:cd17355 13 ILSWGIRYYFGVFIIpiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV-LLALATSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 103 SELVLIGILLGVAGAS--FAVALPMASRWYPPHLQGVAMGIAGAGNSGTliSTLFGP---RLAEIYGWH------AVMGL 171
Cdd:cd17355 92 WQLYLLWGLLGGGGAGtlAAVAFATVAAWWFERRRGLALGILTAGGGLG--SLVFLPlgaALIEAFGWRtallvlALLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 172 ALIPLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQ-VKSTWFFCLLYAITFGGF--VGLSSFLSIFFVDQyGVSKIHAG 248
Cdd:cd17355 170 LVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEaLRSASFWLLALAFFLCGFavVGLIVHLVPYLADR-GISPAAAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 249 DFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIAL--LFVGMMCLGMGNGAVFQLVPQV 326
Cdd:cd17355 249 VALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfaALFGLGWGATVPLTAALAARYF 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2410419435 327 FHKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVV 383
Cdd:cd17355 329 GARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
25-320 |
1.46e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 25 SFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKK-----TAVIGMLLTTI--PLIWGFI 97
Cdd:COG2211 23 NLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALsfVLLFTAP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 98 AGTTLSELVLIGILLGVAGASFAVALPMASRWYP-----PHLQGVAMGIAGA-GNSGTLISTLFGPRLAEIY------GW 165
Cdd:COG2211 103 DLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWRFAfAGLGGLLASVLPPPLVAAFggdaalGY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 166 HAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQP--IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVS 243
Cdd:COG2211 183 RLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVslKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2410419435 244 KIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVviALLFVGMMCLGMGNGAVF 320
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNL--WLLLVLAALAGIGLGAIL 337
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
30-331 |
3.29e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.90 E-value: 3.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 30 VLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTLSeLVLIG 109
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ-LALLR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 110 ILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAG-NSGTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFfifta 187
Cdd:cd17365 95 FLTGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 188 kdapnqpapqpirsyfsvfqVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQyGVSKIHAGDFVTLCVAAGSFFRPVGGL 267
Cdd:cd17365 170 --------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGW 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2410419435 268 IADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVI-ALLFVGMMCLGMGNGAVFQLVPQVFHKEI 331
Cdd:cd17365 229 LADRFGPKRVLALFFALGAVSLALLGVSPASLVLLyVLVFLAGACVNGAQVGLYALAARFYPTEV 293
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-185 |
3.82e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 2 KLSELKSSGHPKTLFGSFLYFDVSFMIWVLLGA-LGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKT 80
Cdd:cd17325 188 LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPfLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 81 AVIGMLLTTIPLIWgFIAGTTLSELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAG-AGNSGTLISTLFGPR 158
Cdd:cd17325 268 ILIGLLLSAVALLL-LPLATSFWLLLLLLALLGLGlGLVFPATLALLADIVPPEGRGTAMGLFNtAFSLGMVLGPLLGGF 346
|
170 180
....*....|....*....|....*..
gi 2410419435 159 LAEIYGWHAVMGLALIPLSLVFLFFIF 185
Cdd:cd17325 347 LYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
69-314 |
4.36e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.50 E-value: 4.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 69 GLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLSELVLIGILLGVAGASFA-VALPMASRWYPPHLQGVAMGIAGAGNS 147
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLA-PNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVIL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 148 -GTLISTLFGPRLAEIYGWHAVMgLALIPLSLVFLFFIftakdapnqpapqPIRSyFSVFQVKSTWFFCLLYAITFGGFV 226
Cdd:cd17503 131 lAPAIGPTLGGWLTDNLSWRWIF-YINLPIGILALLLA-------------PLLD-LRLFKDRNFTLGLLLSFLLGLGLF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 227 GLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGIC---LGGVSSLPALPVVIA 303
Cdd:cd17503 196 GAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGtllLAFLTPDTSLWLIIL 275
|
250
....*....|.
gi 2410419435 304 LLFVGMMCLGM 314
Cdd:cd17503 276 PLFIRGLGMGL 286
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-312 |
4.89e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.53 E-value: 4.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 51 GMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTTlsELVLIGILLGVAGASFAVALPMASRWY 130
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI--YGLILGRALQGSGAISSVVMALLADLT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 131 PPHLQGVAMGIAGAGNSGT-LISTLFGPRLAEIYGWHAVMGLALIpLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQVK 209
Cdd:cd17472 113 REENRTKAMALIGASIGIAfAISMVLGPLLAAHLGVSGLFLITAI-LSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 210 STWFFCLLYaitFGGFVgLSSFLSIFFV------DQYGVSKIHAGdFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFG 283
Cdd:cd17472 192 KNKRLLRLD---FSIFI-LHFVLMAFFYilplllTQLGGGKGQLW-KVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSS 266
|
250 260 270
....*....|....*....|....*....|....*
gi 2410419435 284 IIGICLGGVSSLPA---LPVVIALL---FVGMMCL 312
Cdd:cd17472 267 ILLIAVGFLLLLFAatsLWLLIIGLiifFIGFNLL 301
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-383 |
1.61e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.66 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIpLIWGFIAGTTLSELVLIGILLG-VAGA 117
Cdd:cd17312 29 IVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL-ANIFMGFSTSLWFFAVLWGLNGlFQSM 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 118 SFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFTAKDAPnqpap 196
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNfGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP----- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 197 qpirsyfsvfqvKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGG-- 274
Cdd:cd17312 183 ------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGgr 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 275 ---MKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGN---GAVFQLVPQvfHKEIGIVTGIVGAAGGIGGFF 348
Cdd:cd17312 251 rapIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINligGAAAQDIGR--KEAAGTATGFVGLFGYLGASL 328
|
330 340 350
....*....|....*....|....*....|....*
gi 2410419435 349 LPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVV 383
Cdd:cd17312 329 AGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
32-322 |
1.85e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 32 LGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwgfIAGTTLSELVLIGIL 111
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGIL---LRSLGGIALLFLGTA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 112 LGVAGASFA-VALPMASRWYPPHLQGVAMGI--AGAGNSGTLISTLFGP-RLAEIYGWHAVMGLALIPLSLVFLFFIFTA 187
Cdd:cd17339 95 LAGAGIAVGnVLLPSLIKRDFPRRVGLMTGLytTSMNLGAALASGLSVPlAQALGGGWRGALAIWALPALLALLIWLPQL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 188 KDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQyGVSKIHAGDFVTLCVAAGSFFRPVGGL 267
Cdd:cd17339 175 RRRKRAAAAAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDA-GLSAATAGWLLSLFQLVGIPASLLVPI 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 268 IADKIG---GMKVLLGLFGIIGicLGGVSSLPAlpvviALLFVGMMCLGMGNGAVFQL 322
Cdd:cd17339 254 LATRLKnqrPIVVLLAVLFIIG--VLGLLFAPT-----ALALLWAVLLGLGGGAAFSL 304
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
18-337 |
3.17e-07 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 52.24 E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 18 SFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMiVAIPILSGSFF-RIVLGLFTDRIGPKKTAVIGMLLTTIP-LIWG 95
Cdd:PLN00028 41 SWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGN-AGIASVSGSIFsRLAMGPVCDLYGPRYGSAFLLMLTAPAvFCMS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 96 FIagTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIA-GAGNSG----TLISTLFGPRLAEIYG-----W 165
Cdd:PLN00028 120 LV--SSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGggvtQLLMPLVFPLIKDAGApsftaW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 166 HAVMGLALIPLSLVFLFFIFTAKDAP-------NQPAPQPIRSYFSVFQ--VKS--TWFFCLLYAITFGGFVGLSSFLSI 234
Cdd:PLN00028 198 RIAFFVPGLLHIIMGILVLTLGQDLPdgnyrelKKSGTMPKDSFSKVLRygVTNyrTWILALTYGYSFGVELTMDNIIAE 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 235 FFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIG---GMK-------VLLGLFGIIGICLGGVSSLPALPVVIAL 304
Cdd:PLN00028 278 YFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAArrfGMRgrlwalwIVQTLGGVFCIWLGRANSLGAAIVVMIL 357
|
330 340 350
....*....|....*....|....*....|....*
gi 2410419435 305 --LFVGMMClgmgnGAVFQLVPQVFHKEIGIVTGI 337
Cdd:PLN00028 358 fsIFVQAAC-----GATFGIVPFVSRRSLGVISGL 387
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
37-293 |
1.28e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 37 AFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAgTTLSELVLIGILLGV-A 115
Cdd:COG0477 38 PSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA-PSPELLIAARALQGIgA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 116 GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFTAKDAPNQP 194
Cdd:COG0477 117 GGLMPGALALIAELFPARERGRALGLWGAAIGlGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 195 APQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGG 274
Cdd:COG0477 197 ALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLL 276
|
250
....*....|....*....
gi 2410419435 275 MKVLLGLFGIIGICLGGVS 293
Cdd:COG0477 277 ALLLLLLLLLLLLLLALLL 295
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-361 |
1.86e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 37 AFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTLSELVLIGILLGVA- 115
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNL-FFGFSTSLWVMAALWALNGIFq 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 116 GASFAVALPMASRWYPPHLQGVAMGIAGAGNS--GTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFTAKDAPNQ 193
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNvgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 194 PAPQPIRSYFS-----------------------VFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDF 250
Cdd:TIGR00881 178 CGLPPAEEMPNeepdgdaekkeeeltkkqiflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 251 VTLCVAAGSFFRPVGGLIADKI-GGMKVLLGLFGIIGI--CLGGVSSLPAL--PVVIALLFV-GMMCLGMGNGAVFQLVP 324
Cdd:TIGR00881 258 FTLYELGGLVGTLLAGWLSDKLfNGRRGPLAVFFMALIivSLLVYWLNPAAnpLMDLICLFAlGFLVYGPQMLIGVIASE 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 2410419435 325 QVFHKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTG 361
Cdd:TIGR00881 338 LAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
15-381 |
2.02e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 49.47 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIW 94
Cdd:cd17352 5 VFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 95 GFIAGTTLSELVLIGILLGVA-GASFAVALPMASRWYPpHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWH-AVMGL 171
Cdd:cd17352 85 SSFATSLWQLYLTYGVLGGLGlGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGvGTFVFPPLLRYLLDNYGWRgALLIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 172 ALIPLSLVFLFFIFTAkdapnqpapqpirsyfsvfqVKSTWFFCLLYAITFGGFVGLSSFLSI-FFVDQYGVSKIHAGDF 250
Cdd:cd17352 164 GGLCLNLCVCGLLLRL--------------------LKDPTFVLLALGVSFAMLGFFVPFVYLpSYAKSLGIDESDAAFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 251 VTLCVAAGSFFRPVGGLIADK--IGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQLVPQVFH 328
Cdd:cd17352 224 LSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 329 KE-----IGIVTGIVGAAGgiggFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCL 381
Cdd:cd17352 304 LEklsnaYGLVLLFQGLAA----LVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-314 |
2.45e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 8 SSGHPKTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLL 87
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 88 TTIPLIWGFIAgTTLSELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAG-NSGTLISTLFGPRLAEIYGW 165
Cdd:TIGR00895 92 FSVFTLLCALA-TNVTQLLILRFLAGLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 166 HAVMGLA-LIPLSLVFLFFIF--------------TAKDAPNQPAPQPIRSYFSVFQV---------------------K 209
Cdd:TIGR00895 171 RSLFYVGgIAPLLLLLLLMRFlpesidflvskrpeTVRRIVNAIAPQMQAEAQSALPEqkstqgtkrsvfkalfqgktaR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 210 STWFFCLLYAITFGGFVGLSSFLSIFFVDQyGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIgGMKVLLGLFGIIGICL 289
Cdd:TIGR00895 251 ITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRL-GPRVTALLLLLGAVFA 328
|
330 340
....*....|....*....|....*..
gi 2410419435 290 GGVSSLPALPVVIALL--FVGMMCLGM 314
Cdd:TIGR00895 329 VLVGSTLFSPTLLLLLgaIAGFFVNGG 355
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-185 |
4.53e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 14 TLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLI 93
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 94 WGFIAGTTLSELVLIG--ILLGVAGASFAVALPMASRWYPPHLQGVAMGIA-GAGNSGTLISTLFGPRLAEIYGWHAVMG 170
Cdd:cd17316 259 PLFYLLSGSPTLLLLLlfILSFFVGGVWGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
170
....*....|....*
gi 2410419435 171 LALIPLSLVFLFFIF 185
Cdd:cd17316 339 LILALLAIVALIVAL 353
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
39-168 |
7.19e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.55 E-value: 7.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVaipilsGSFF------RIVLGLFTDRIGPKKTAVIGMLL-TTIPLIWGFIAGTTLSELVLIGIL 111
Cdd:cd17380 25 MAKEFGWSKTDQGLVL------SSFFwgyaltQVLGGYLADRFGGKKVLLLAVALwSLATLLTPLLAYSSLPLLILSRIL 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2410419435 112 LGVAGAsfaVALP----MASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAV 168
Cdd:cd17380 99 LGLGEG---VHFPsmtsLFSRWVPVSERSRAVSIVTAGSYlGTLLGGLIGPLLLEYYGWPSV 157
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
15-320 |
1.09e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.30 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTI-PLI 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVfTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 94 WGFiaGTTLSELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-----GTLISTLFGPRLAEIYGWHA 167
Cdd:cd17371 81 CGF--AQNYWQLLILRALAGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwllATLLAALLFPLLPPEIAWRV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 168 VMGLALIPLSLVFLFF-------IFTAKDAPNQPAPQP--IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVD 238
Cdd:cd17371 159 LFLLGALPALLVLFIRrfvkeppQWQAARAARRHFADRpsLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 239 QYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLfvgMMCLGMGNGA 318
Cdd:cd17371 239 ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILIL---GFPLGFFASG 315
|
..
gi 2410419435 319 VF 320
Cdd:cd17371 316 PF 317
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-186 |
1.85e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 63 FFRIVLGLFTDRIGPKKTAVIGMLLTTIPLiWGFIAGTTLSELVLIGILLGVAGASFAVAL-PMASRWYPPHLQGVAMGI 141
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGL-LLLSFAGSPWMLLLAAVLYGLGFGLLFPALqALAVDLVPPHRRGAANGT 320
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2410419435 142 -AGAGNSGTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFT 186
Cdd:cd17489 321 fFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
39-320 |
2.33e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 39 IAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTLSELVLIGILLGVAGAS 118
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL-LCALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 119 FAVALPMASR-WYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAV----MGLALIPLSLVFLFFIFTAKDAPN 192
Cdd:cd17320 104 GSVVARAIVRdLYSGAELAKIFSLLMMILAiAPALAPLLGGLLLLFFGWRAIfvflALLGLLLLLLVLLFLPETLPEEKR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 193 QPAPQPI-RSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADK 271
Cdd:cd17320 184 KPLLSSLlRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRR 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2410419435 272 IGGMKVLLGLFGIIGICLGGVSSLP-ALPVVIALLFVGMMCLGMGNGAVF 320
Cdd:cd17320 264 FGPRRLLRLGLLLLLAAALVLLLAAlLGGLSLWPLVAPLFLIFFGFGLIF 313
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
52-322 |
3.87e-05 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 45.48 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 52 MIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTtlSELVLIGILLGVAGASFAVAL--PMASRW 129
Cdd:cd17410 38 LLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGT--GPTLIASALLGGLGIAIIQALvpGLIKRR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 130 YPPHLQgVAMGIAGAG-NSGTLISTLFGPRLAEIY-GWHAVMGLALIP--LSLVFLFFIFTAKDAPNQPAPQPIRsyfsV 205
Cdd:cd17410 116 FPARVP-LAMGLYSASlMAGGGLAASLSPRLAQHSaGWQLGLGIWAVPalVALVLWWRQPPREVAPSDTAGPGVR----F 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 206 FQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQyGVSKIHAGD---FVTLCVAAGSFFRPVggLIADKIGGMKVLLGLf 282
Cdd:cd17410 191 FRNRRAWLLALYFGLINAGYTSMIAWLPAYYLEL-GWSAQDSGSllgFMTIFQVLGALVMPA--LARRSADRRPLLMGA- 266
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2410419435 283 giIGICLGGVSSLPALPVVIALLFVgmMCLGMGNGAVFQL 322
Cdd:cd17410 267 --LAAQLAGFLGLILMPQSLPLLWV--ALIGLGLGACFSL 302
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-148 |
5.32e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 11 HPKTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTI 90
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 91 PLIWGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGAGNSG 148
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-307 |
8.18e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 51 GMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIpLIWGFIAGTTLSELVLIGILLGVAGASFAVALPMA-SRW 129
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAV-SVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWlNAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 130 YPPHLQGVAMGIAGAGNSGTLISTLFGPRLAEIYGWHAVMGLALIpLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQVK 209
Cdd:cd17477 113 ATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVL-LLLALVPLLLTRRAAPEIEEAESISLRRLLRIAP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 210 STWFFCLLYAITFGGFVGLSSFlsifFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICL 289
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPL----YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAA 267
|
250
....*....|....*...
gi 2410419435 290 GGVSSLPALPVVIALLFV 307
Cdd:cd17477 268 LLLPLVPGLPLALLVLLF 285
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
24-279 |
3.78e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 42.36 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 24 VSFMIWVL-LGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIP-LIWGFIAGTT 101
Cdd:PRK12382 26 LTYMTVGLpLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAgLAYLLAAILP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 102 LSELVLIGILL---GVAGASFAVALPMASRWY-----PPH------LQGVAM--GIAGAGNSGTLISTLFGprlaeiygw 165
Cdd:PRK12382 106 VSAPFKFALLVvgrLILGFGESQLLTGALTWGlglvgPKHsgkvmsWNGMAMygALAAGAPLGLLLHSHFG--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 166 HAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQPirSYFSVfqVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYgvski 245
Cdd:PRK12382 177 FAALALTTMVLPLLAWAFNGTVRKVPAHAGERP--SLWSV--VGLIWKPGLGLALQGVGFAVIGTFVSLYFASKG----- 247
|
250 260 270
....*....|....*....|....*....|....*.
gi 2410419435 246 HAGDFVTLCVAAGSFF--RPVGGLIADKIGGMKVLL 279
Cdd:PRK12382 248 WAMAGFTLTAFGGAFVlmRVLFGWMPDRFGGVKVAI 283
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-320 |
4.05e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 40 AQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTtLSELVLIGILLGVAGASF 119
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN-LWLLFLARFLDGLTGGNV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 120 AVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGwHAVMGLALIPLSLVFLFFIFtakdapnqpapqp 198
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGlGFILGPALGGFLSTPYG-YALPFLVAAALALLNLVLVL------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 199 irsyfsvFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFR-PVGGLIADKIGGMKV 277
Cdd:cd17330 171 -------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKL 243
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2410419435 278 LLGLFGIIGICLGGVSSLPALPvviaLLFVGMMCLGMGNGAVF 320
Cdd:cd17330 244 LRLGLLLAIIGLLLLPFASSVP----LLVLAAAILAFGTGIVF 282
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
13-191 |
4.76e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.22 E-value: 4.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 13 KTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPL 92
Cdd:PRK12307 18 NALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 93 -IWGFIAGTTLSELVLIGILLGVAGaSFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMG 170
Cdd:PRK12307 98 gLSGLASGVIMLTLSRFIVGMGMAG-EYACASTYAVESWPKHLKSKASAFLVSGFGiGNIIAAYFMPSFAEAYGWRAAFF 176
|
170 180
....*....|....*....|.
gi 2410419435 171 LALIPLSLVflffIFTAKDAP 191
Cdd:PRK12307 177 VGLLPVLLV----IYIRARAP 193
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
37-384 |
6.21e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.60 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 37 AFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGML---LTTIPLIWGFIAGTtlseLVLIGILLG 113
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFifaLSSLGLALSNNIET----LLVLRFVQA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 114 VAGASFAVAL-PMASRWYPPHLQGVAMGIAGagnSGTLISTLFGPRLA----EIYGWHAV----MGLALIPLSLVFLFFI 184
Cdd:TIGR00710 105 FGASAGSVISqALVRDIYPGEELSRIYSILM---PVLALAPAVAPLLGgyilVWLSWHAIfaflSLAGILLSALIFFILP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 185 FTAKDAPNQPAPQPIRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPV 264
Cdd:TIGR00710 182 ETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 265 GGLIADKIGGMKVL---LGLFGIIGICL--GGVSSLPALPVVIALlfvgMMCLGMGNGAVFQLVPQVFHKEIGIVTGIVG 339
Cdd:TIGR00710 262 NGRFIKKWGAKSLLrmgLILFAVSAVLLeiTAILGLGSWAMIIGP----MMFVGIGNSMISSIAMAYALEDFPHVAGTAS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 2410419435 340 AAGGIGGFFLPNILGSLKELtgsytFGFLTISLFVLIVFLCLVVS 384
Cdd:TIGR00710 338 ALFGTLRLVLGAIVGYLVSL-----IHGNTAWPMSLSCLVLAVVS 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
51-322 |
1.16e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 51 GMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIG----MLLTTIPLIWGFIAGTTLSELVLIGILLGVAGASFAVA---- 122
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPArqal 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 123 LPMASRwyPPHLQGVAMGIAGAGNSGTLISTLFGPRLAEIYGWHAVMGLALI--PLSLVFLFFI-FTAKDAPNQPAPQPI 199
Cdd:cd06173 117 LPELVP--KEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsfLLSALLLLFIrRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 200 RSYFSVFQV----KSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLC---VAAGSFFRPVGGLIADKI 272
Cdd:cd06173 195 RDLREGLRYlrrsPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFgvgALLGALLLGRLSKRRRRG 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2410419435 273 GGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQL 322
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-307 |
1.22e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGAlgaFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIW 94
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAI---YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 95 GFIAGTTLSELVLIgILLGVAGASFAVALP--MASRWYPPHLQGVAMGIAGAGNSGTLISTLFGPRLAEIYGWHAVMGLA 172
Cdd:cd17329 82 LGFAHSPWLFAIAL-VLTGFGGGLFEPASEamIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 173 LIPLsLVFLFFIFTAKDAPNQPAPQP----IRSYFSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAG 248
Cdd:cd17329 161 VLFL-LAALVLLFLLPETRPKRRAAEkteiLRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLG 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2410419435 249 DFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFV 307
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV 298
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
203-321 |
2.28e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 203 FSVFQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLF 282
Cdd:cd17502 161 LALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIG 240
|
90 100 110
....*....|....*....|....*....|....*....
gi 2410419435 283 GIIGICLGGVSSLPALPVVIALLFVGMMCLGMGNGAVFQ 321
Cdd:cd17502 241 TILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQ 279
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
27-301 |
2.28e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 40.08 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 27 MIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIWGFIAGTT--LSE 104
Cdd:cd17334 18 MQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQqpKFA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 105 LVLIGILLGVAGASFAVALP--MASRWYPPHLQGVAMGIAGAGNS-----GTLISTLF-GPRLAEIYGWHAVM----GLA 172
Cdd:cd17334 98 LLVLGQVLNALAQVLVLSLPplIAAVWFPPKERTTATAIASLANFlgcaiGFLLPPVVvPPPKGTKKEFGAVFygefGFA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 173 LIPLSLVFLFFIFTAKDAPNQPA------PQPIRSYF----SVFQVKSTWFFCLLYAITFGGFVGLSSFLSiFFVDQYGV 242
Cdd:cd17334 178 CLLLALVLALFPPKPKYPPSAASarqqnsEHVILELQksisELLRNEPFVLLAVAFSIMMGVFAGFSSVLA-QILLPFGV 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2410419435 243 SKIHAGDFVTLCVAAGSFFRPVGGLIADKIGgmkvLLGLFGIIGICLGGVSSLPALPVV 301
Cdd:cd17334 257 SQTSAGWLGFFGIVAGMVGGLLLGLFVDRTR----MFKLIGLIILALGTVVCTFFMLLV 311
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-280 |
2.40e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 51 GMIVAIPILSGSFFRIVLGLFTDRIGPKKT---AVIGMLLTTIPLiwGFIagTTLSELVLIGILLGVAGASFAVALPMAS 127
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMllrASLGMAIVIGLM--AFV--TNVWQLLILRLLQGVFSGYVPNATALIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 128 RWYPPHLQGVAMG-IAGAGNSGTLISTLFGPRLAEIYGWHAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVF 206
Cdd:cd17391 115 SQTPKEKSGWALGtLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 207 Q-VKSTWFFCLLYAITFGGFVGLSSFLSIF--FVDQYGVSKIHAGDFVTLCVAAGSF----FRPVGGLIADKIGGMKVLL 279
Cdd:cd17391 195 NsVPNPSLLISLFVTTFIIQLANQSIEPILtlYIRQLMGDASNLAFISGLVFSATGVssllSAPRLGKLGDRIGHHRILL 274
|
.
gi 2410419435 280 G 280
Cdd:cd17391 275 G 275
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
32-322 |
2.57e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 39.56 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 32 LGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTT-------IPLIWGFIAGTtlse 104
Cdd:cd17409 18 VAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAagialrsTGSVWALYLGT---- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 105 lVLIGIllGVAGASfaVALPMASRWYPPH-------LQGVAMGIAGAGNSGTLISTLfgprLAEIYGWHAVMGlALIPLS 177
Cdd:cd17409 94 -AIIGA--GIAIGN--VLLPSLLKRDFPArvatltgAYALTMGVGAALGSALVVPLA----QVLAFGWQLALG-AFLVFP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 178 LVFLFFIFTAKDAPNQPAPQPIrsyfSVFQVKSTWFFCLLYAITFggFVGLSSFLSIFFVD-------QYGVSKIHAGD- 249
Cdd:cd17409 164 LVAALIWLPQLRRHTSPAADTA----KPPHGGSVWRSPLAWQVTL--FLGLNSFIYYVLVGwlpsiltDAGYSAAQAGSl 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2410419435 250 --FVTLCVAA-GSFFRPVGGLIADK--IGGMKVLLGLFGIIGICLggvssLPALPVVIALLFvgmmclGMGNGAVFQL 322
Cdd:cd17409 238 hgLLQLATAVpGLLLIPVLARMKDQrlLAVLVSLLGAVGLIGLLL-----APSLAILWVILF------GFGSGAGFIL 304
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-186 |
3.48e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 12 PKTLFGSFLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGP---KKTAVIGMLLT 88
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 89 TIPLIWGFIAGTTLSELVLIGILLGVAGASFAVALPMASRWYPPHLQGVAMGIAGA-GNSGTLISTLFGPRLAEIYGWHA 167
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSgGNLGGFVAPLLIGYLVDATGSYT 338
|
170
....*....|....*....
gi 2410419435 168 VMGLALIPLSLVFLFFIFT 186
Cdd:cd17319 339 AAFLFLAAVALLAALLVLL 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
14-184 |
3.95e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 14 TLFGSFLYFDVSFMIwvllgalgaFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLI 93
Cdd:cd17370 209 VALFALGNFSFAFLI---------LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 94 wGFIAGTTLSELVLIGILLGVAGASFAVALP-MASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGWHAVMGL 171
Cdd:cd17370 280 -GFALGSSLWLLLLGFILWGLYMGAQESIERaAVADLVPAELRGTAYGLFNTVVGiGWLLASLIAGYLWDLISPSAAFLF 358
|
170
....*....|...
gi 2410419435 172 ALIPLSLVFLFFI 184
Cdd:cd17370 359 SAVLALIALLLLL 371
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
40-165 |
4.02e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 40 AQDFALTTVEKGMIVaipilsGSFF------RIVLGLFTDRIGPKKTAVIGMLLT-----TIPLI--WGFIAgttlseLV 106
Cdd:cd17318 48 APEFDWSEKTQGIIL------SSFFygyiltQIPGGYLAEKYGAKRVLGYSILITalltlLTPLAarGGYGA------LI 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2410419435 107 LIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLAEIYGW 165
Cdd:cd17318 116 VLRILQGLAqGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQfGTVIAMPLSGFLCESLGW 176
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
66-383 |
5.01e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 66 IVLGLFTDRIGPKKTAVIGMLL-----TTIPLIWGF----IAGTTLseLVLIGILLGVA-GASFAVALPMASRWYPPHLQ 135
Cdd:cd17369 62 VVFGHFGDRIGRKKTLVLTLLLmgiatFLIGLLPTYaqigILAPIL--LVLLRLLQGLAlGGEWGGAVLMAVEHAPPKRR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 136 GVAMGIAGAG-NSGTLIST--------LFGPRLAEIYGWHaVMGLALIPLSLVFLFF--------IFTAKDAPNQPAPQP 198
Cdd:cd17369 140 GFYGSFPQLGaPVGLLLATgvflllsaLLSDEAFLSWGWR-IPFLLSAVLVAVGLYIrlrleetpVFRRAKEAGQVVRAP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 199 IRSYFSVfQVKSTWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVL 278
Cdd:cd17369 219 LVEVLRR-HWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVY 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 279 lglfgIIGICLGGVSSLPA---------LPVVIALLFVGMMCLGMGNGAVFQLVPQVFHKEI--GIVTGIVGAAGGIGGF 347
Cdd:cd17369 298 -----LAGALLAALFAFPFfwlldtgstWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVryTGASLGYQLGAILGGG 372
|
330 340 350
....*....|....*....|....*....|....*.
gi 2410419435 348 FLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLVV 383
Cdd:cd17369 373 FAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
52-313 |
5.40e-03 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 38.79 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 52 MIVAIPI-LSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIAGTTLSELVLIGILLGVAGASFAVALP--MASR 128
Cdd:cd17399 49 MIVSIPVgFVAMWLLDTLGLRTAIILGAWLNFIGAVIRVISSL-PFVDPSFRFPVLMTGQTLAAFAQPFILFLPtkLAAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 129 WYPPHLQGVAMGIAGAGNS-GTLISTLFGPRLA----EIYGWHAVM-GLALIPLslVFLFFIFTAKDAPNQPAPQPIRSY 202
Cdd:cd17399 128 WFPDNQRAIANMLASMSNPlGVLLANLLSPLIVksseDIFLLLSIYtIPALIAV--VLATFGVRSSVPPTPPSASAAHES 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 203 FSVFQVKSTWFFCLLY---AITFGGFVGLSSFLSIfFVDQ----YGVSKIHAGDFVTLCVAAGSFFRPVGGLIADK---- 271
Cdd:cd17399 206 EPFFVGLKQLFKNKQYlilMLCFGGGIGLFNALST-LLEQilcpSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKtkkf 284
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2410419435 272 IGGMKVLLGLFGIIGICLGGVSSLPALPVVIALLFVGMMCLG 313
Cdd:cd17399 285 IEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFG 326
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
19-382 |
6.37e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 19 FLYFDVSFMIWVLLGALGAFIAQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIwGFIA 98
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALA-LIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 99 GTTLSELVLIGILLGVA-GASFAVALPMASRWYPpHLQGVAMGIAGA-----GNSGTLISTLFGPRLAEIYGWHAVMGLA 172
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGaGILDTGANTFVGALFE-ESSATRLNVLHGffglgALIGPLIATSLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 173 LIPLSLVFLFFIFTAKDAPNQPAPQPIRSYFSVFQVK---STWFFCLLYAITFGGFVGLSSFLSIFFVDQYGVSKIHAGD 249
Cdd:cd17333 160 YLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLrnpSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 250 FVTLCVAAGSFFRPVGGLIADKIGgMKVLLGLFGIIGICLGGVSSLPALPVVialLFVGMMCLGMGNGAVFQ----LVPQ 325
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIK-PHTLLVLSGSGALLGLLILLLAPTLVV---GLVATALLGLFMAALFPtilsLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2410419435 326 VFHKEIGIVTGIVGAAGGIGGFFLPNILGSLKELTGSYTFGFLTISLFVLIVFLCLV 382
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
142-323 |
8.03e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.35 E-value: 8.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 142 AGAGNSGTLISTLFGPRLAEIYG-------WHAVMGLALIPLSLVFLFFIFTAKDAPNQPAPQPI-----RSYFSVFQVK 209
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGggnasrgYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklpllKSLKALLKNR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 210 STWFFCLLYAITFGGFVGLSSFLsIFFVDQYGVSKIHAGDFVTLCVAAGSFFRPVGGLIADKIGGMKVLLGLFGIIGICL 289
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVL-VYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
170 180 190
....*....|....*....|....*....|....
gi 2410419435 290 GGVSSLPALPVViaLLFVGMMCLGMGNGAVFQLV 323
Cdd:cd17332 301 LLLFFLPPGNLV--LILVLAVLAGIGYGGANLLP 332
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
15-141 |
9.12e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 37.82 E-value: 9.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2410419435 15 LFGSFLYFDVSFMIWVLLGALGAfiaQDFALTTVEKGMIVAIPILSGSFFRIVLGLFTDRIGPKKTAVIGMLLTTIPLIW 94
Cdd:COG2270 244 LLAYFFYRDGVQTVIAFAGIYAA---GVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLA 320
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2410419435 95 GFIAGTTLsELVLIGILLGVA-GASFAVALPMASRWYPPHLQGVAMGI 141
Cdd:COG2270 321 AYFLTTAL-AFWILGLLIGLVmGGIQALSRSLLARLIPPGREAEFFGL 367
|
|
| |
