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Conserved domains on  [gi|2414735783|ref|WP_268926796|]
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DNA cytosine methyltransferase [Mycoplasmopsis gallopavonis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dcm super family cl43082
DNA-cytosine methylase [Replication, recombination and repair];
1-41 7.71e-09

DNA-cytosine methylase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0270:

Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 49.81  E-value: 7.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2414735783   1 MKTFLSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDYK 41
Cdd:COG0270   131 ILKELEELGYRVDYKVLNAADYGVPQNRERVFIVGFRKDLD 171
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-41 7.71e-09

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 49.81  E-value: 7.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2414735783   1 MKTFLSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDYK 41
Cdd:COG0270   131 ILKELEELGYRVDYKVLNAADYGVPQNRERVFIVGFRKDLD 171
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
5-72 3.78e-07

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 45.38  E-value: 3.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY-KTPFNNDEEYLLYLNKIGQKyVLNDIEERKKK 72
Cdd:pfam00145 129 LEELGYHVSWKVLNASDYGVPQNRERVFIVGIRKDLnLNVLVPVPEFDFPKPKDLTG-TIRDLLEEPSL 196
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 5-40 5.05e-07

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 44.92  E-value: 5.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY 40
Cdd:cd00315   131 LEELGYNVYWKLLNASDYGVPQNRERVFIIGIRKDL 166
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 5-45 2.81e-03

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 34.22  E-value: 2.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY-KTPFN 45
Cdd:TIGR00675 128 LEELGYKVYYKVLNAKDFGVPQNRERIYIVGFRDFDdKLNFE 169
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-41 7.71e-09

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 49.81  E-value: 7.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2414735783   1 MKTFLSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDYK 41
Cdd:COG0270   131 ILKELEELGYRVDYKVLNAADYGVPQNRERVFIVGFRKDLD 171
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
5-72 3.78e-07

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 45.38  E-value: 3.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY-KTPFNNDEEYLLYLNKIGQKyVLNDIEERKKK 72
Cdd:pfam00145 129 LEELGYHVSWKVLNASDYGVPQNRERVFIVGIRKDLnLNVLVPVPEFDFPKPKDLTG-TIRDLLEEPSL 196
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 5-40 5.05e-07

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 44.92  E-value: 5.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY 40
Cdd:cd00315   131 LEELGYNVYWKLLNASDYGVPQNRERVFIIGIRKDL 166
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 5-45 2.81e-03

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 34.22  E-value: 2.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2414735783   5 LSNLGYKTFTGILNASNHGSLQNRERVFAISVLKDY-KTPFN 45
Cdd:TIGR00675 128 LEELGYKVYYKVLNAKDFGVPQNRERIYIVGFRDFDdKLNFE 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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