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Conserved domains on  [gi|2427153552|ref|WP_270355600|]
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MFS transporter [Longicatena caecimuris]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 12-262 2.14e-46

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 163.94  E-value: 2.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILV 91
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYL--SLGRIPIIPLFIVALmLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINP 169
Cdd:cd06173    81 LALlaLLGSLSLWLLLVLAF-LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 170 ILIVSIICFTLSAIMEIFIHIPHQKTPREvgVIAVAKNDLKDSYTFLKREKPIFIsvIFLVCIFNLVLSAVLIVGLPILI 249
Cdd:cd06173   160 AFAINALSFLLSALLLLFIRRPPPAAPGE--SSSLLLRDLREGLRYLRRSPLLRL--LLLALALFALLGGALTVLLPLLA 235

                         250
                  ....*....|...
gi 2427153552 250 SEVLKMPDTLYGF 262
Cdd:cd06173   236 KEVLGGGAAGYGL 248
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 12-262 2.14e-46

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 163.94  E-value: 2.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILV 91
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYL--SLGRIPIIPLFIVALmLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINP 169
Cdd:cd06173    81 LALlaLLGSLSLWLLLVLAF-LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 170 ILIVSIICFTLSAIMEIFIHIPHQKTPREvgVIAVAKNDLKDSYTFLKREKPIFIsvIFLVCIFNLVLSAVLIVGLPILI 249
Cdd:cd06173   160 AFAINALSFLLSALLLLFIRRPPPAAPGE--SSSLLLRDLREGLRYLRRSPLLRL--LLLALALFALLGGALTVLLPLLA 235

                         250
                  ....*....|...
gi 2427153552 250 SEVLKMPDTLYGF 262
Cdd:cd06173   236 KEVLGGGAAGYGL 248
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-267 1.55e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 1.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   1 MQAEKKLFNHDFILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVI 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  81 LDFVTAIIILVFYLSlgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGV 160
Cdd:COG2814    81 GLLLFALGSLLCALA----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 161 VFQFYGINPILIVSIICFTLSAIMeIFIHIPHQKTPREVGVIAVAKNDLKDsytflkrekPIFISVIFLVCIFNLVLSAV 240
Cdd:COG2814   157 LADLFGWRWVFLVNAVLALLALLL-LLRLLPESRPAARARLRGSLRELLRR---------PRLLLLLLLAFLLGFGFFAL 226

                         250       260
                  ....*....|....*....|....*..
gi 2427153552 241 LIVgLPILISEVLKMPDTLYGFSISII 267
Cdd:COG2814   227 FTY-LPLYLQEVLGLSASAAGLLLALF 252
MFS_1 pfam07690
Major Facilitator Superfamily;
15-268 1.11e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  15 VVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFY 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  94 LSLGripiIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIV 173
Cdd:pfam07690  81 FASS----LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 174 SIIcFTLSAIMEIFIHIPHQKTPREVGVIAVAKNDLKDSYTFLKREKPIFISVIFLVCIFNLVLSAVLivglpILISEVL 253
Cdd:pfam07690 157 LAI-LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-----PLYQEVL 230

                         250
                  ....*....|....*
gi 2427153552 254 KMPDTLYGFSISIII 268
Cdd:pfam07690 231 GLSALLAGLLLGLGG 245
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 49-260 4.89e-13

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 71.11  E-value: 4.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   49 IVTACSFLPMVILSLVGGIIADRTNKRNIMVILD----FVTAIIILVFYLSLGRIPIIPLFIVALMllygiSGAYQPAVQ 124
Cdd:PRK08633    51 IVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKlfevGLTLLIVLAYYLGWFWLAFAVTFLLGAQ-----SAIYSPAKY 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  125 ASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQ-FYGINP------ILIVSIICFTLSAIMEIFIH----IPHQ 193
Cdd:PRK08633   126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFEsVNGNTPseilgrIAPAGLVLLAVAVLGLIFAYrlpkVPAA 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2427153552  194 KTPREVGVIAVAKNDLKDSYTFLKREKPIFISVIFLVcIFNLVlSAVLIVGLPILISEVLKMPDTLY 260
Cdd:PRK08633   206 APEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLS-YFWFI-SQLAQANFPAYAKEVLGLDNTFQ 270
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 12-262 2.14e-46

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 163.94  E-value: 2.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILV 91
Cdd:cd06173     1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYL--SLGRIPIIPLFIVALmLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINP 169
Cdd:cd06173    81 LALlaLLGSLSLWLLLVLAF-LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 170 ILIVSIICFTLSAIMEIFIHIPHQKTPREvgVIAVAKNDLKDSYTFLKREKPIFIsvIFLVCIFNLVLSAVLIVGLPILI 249
Cdd:cd06173   160 AFAINALSFLLSALLLLFIRRPPPAAPGE--SSSLLLRDLREGLRYLRRSPLLRL--LLLALALFALLGGALTVLLPLLA 235

                         250
                  ....*....|...
gi 2427153552 250 SEVLKMPDTLYGF 262
Cdd:cd06173   236 KEVLGGGAAGYGL 248
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-267 1.55e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 1.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   1 MQAEKKLFNHDFILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVI 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  81 LDFVTAIIILVFYLSlgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGV 160
Cdd:COG2814    81 GLLLFALGSLLCALA----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 161 VFQFYGINPILIVSIICFTLSAIMeIFIHIPHQKTPREVGVIAVAKNDLKDsytflkrekPIFISVIFLVCIFNLVLSAV 240
Cdd:COG2814   157 LADLFGWRWVFLVNAVLALLALLL-LLRLLPESRPAARARLRGSLRELLRR---------PRLLLLLLLAFLLGFGFFAL 226

                         250       260
                  ....*....|....*....|....*..
gi 2427153552 241 LIVgLPILISEVLKMPDTLYGFSISII 267
Cdd:COG2814   227 FTY-LPLYLQEVLGLSASAAGLLLALF 252
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-194 6.86e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 75.29  E-value: 6.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALF-GIVTACSFLPMVILSLVGGIIADRTNKRNIMVILdfVTAIIIL 90
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQaGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA--IGLLLAA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPI 170
Cdd:COG2271   260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339

                         170       180
                  ....*....|....*....|....
gi 2427153552 171 LIVSIICFTLSAIMEIFIHIPHQK 194
Cdd:COG2271   340 FLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
15-268 1.11e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  15 VVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFY 93
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  94 LSLGripiIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIV 173
Cdd:pfam07690  81 FASS----LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 174 SIIcFTLSAIMEIFIHIPHQKTPREVGVIAVAKNDLKDSYTFLKREKPIFISVIFLVCIFNLVLSAVLivglpILISEVL 253
Cdd:pfam07690 157 LAI-LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-----PLYQEVL 230

                         250
                  ....*....|....*
gi 2427153552 254 KMPDTLYGFSISIII 268
Cdd:pfam07690 231 GLSALLAGLLLGLGG 245
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 21-268 1.25e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.84  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  21 ISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYLSlgriP 100
Cdd:cd17325     7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA----T 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 101 IIPLFIVALMLlYGISGAYQ-PAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVSIICFT 179
Cdd:cd17325    83 SYWQLLLARFL-QGLASAAVwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 180 LSAIMEIFIhIPHQKTPREvgviAVAKNDLKDSYTFLKREKPIFISVIFLVCIFNLVLSAVLIVGLPILISEVLKMPDTL 259
Cdd:cd17325   162 LALVLALLL-LPEPRPPPN----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236


                  ....*....
gi 2427153552 260 YGFSISIII 268
Cdd:cd17325   237 IGLLFGAQG 245
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 49-260 4.89e-13

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 71.11  E-value: 4.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   49 IVTACSFLPMVILSLVGGIIADRTNKRNIMVILD----FVTAIIILVFYLSLGRIPIIPLFIVALMllygiSGAYQPAVQ 124
Cdd:PRK08633    51 IVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKlfevGLTLLIVLAYYLGWFWLAFAVTFLLGAQ-----SAIYSPAKY 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  125 ASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQ-FYGINP------ILIVSIICFTLSAIMEIFIH----IPHQ 193
Cdd:PRK08633   126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFEsVNGNTPseilgrIAPAGLVLLAVAVLGLIFAYrlpkVPAA 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2427153552  194 KTPREVGVIAVAKNDLKDSYTFLKREKPIFISVIFLVcIFNLVlSAVLIVGLPILISEVLKMPDTLY 260
Cdd:PRK08633   206 APEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIGLS-YFWFI-SQLAQANFPAYAKEVLGLDNTFQ 270
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 12-261 5.15e-13

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 70.55  E-value: 5.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIM-VILDFVTAIIIL 90
Cdd:pfam05977  12 FRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMlAGQLLLALVSTL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGRIpIIPLFIVALMLLYGISGAYQ-PAVQASIPLLVSSDKLTvgNAV-INQVN-TLANFIGPAISGVVFQFYGI 167
Cdd:pfam05977  92 LTLLAGLGL-LSPWLLLGLTFLGGIGTALMdPAWQASVPELVPRRDLP--AAVaLNSVGyNIARSVGPALGGVLLAAFGP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 168 NPILIVSIIC--FTLSAIMEIFIHIPHQKTPREVGVIAVakndlKDSYTFLKREKPIFiSVIFLVCIFNLVLSAVLIVgL 245
Cdd:pfam05977 169 AFTFALNALSyfAVIAALWRWKRAAPASPLPRERIFGAV-----RAGLRFTAMSRELR-SVLVRAFAFGLSASAVWAL-L 241

                         250
                  ....*....|....*.
gi 2427153552 246 PILISEVLKMPDTLYG 261
Cdd:pfam05977 242 PLVARDLLDGDAIFYG 257
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-266 2.12e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 68.02  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  13 ILVVIGQIISLFGNAILRFALPYYLLKETGSSALF-GIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIiilv 91
Cdd:cd17329     2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIvGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL---- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYLSLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQfYGINPIL 171
Cdd:cd17329    78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 172 IVSIICFTLSAIMEIFIhIPHQKTPREvgviAVAKNDLKDSYTFLKREKPIFISVIFLVCIFnlVLSAVLIVGLPILISE 251
Cdd:cd17329   157 LAAAVLFLLAALVLLFL-LPETRPKRR----AAEKTEILRGYKIVLRDRAFLLFLLASFLIS--LIYFQLESTLPVYVVE 229

                         250
                  ....*....|....*
gi 2427153552 252 VLKMPDTLYGFSISI 266
Cdd:cd17329   230 ILGLGESLLGLLLAL 244
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
9-184 2.34e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 65.31  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   9 NHDFILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAI 87
Cdd:COG2211   227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGlSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  88 IILVFYLSlgRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGN-------AVINQVNTLANFIGPAISGV 160
Cdd:COG2211   307 GLLLLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFAIKLGQALAGALAGL 384

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2427153552 161 VFQFYGINP---------------ILIVSIICFTLSAIM 184
Cdd:COG2211   385 LLALFGYVAgaaqspsaltgirllFFLLPAVLLLLAALL 423
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
12-268 2.62e-11

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 65.76  E-value: 2.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   12 FILVVIGQIISLFGNAILRFALPY---YLLKETGSSALFGIVT---ACSFLPMVILSLVGGIIADRTNKRNIMVILDFVT 85
Cdd:PRK06814    13 FAPLFWTQFFGAFNDNFLKNALVIlilYGLSGALGAYNNALVTlagAVFILPFFIFSALAGQLADKYDKAKLAKILKFAE 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   86 AIIILV----FYLSlgripIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVV 161
Cdd:PRK06814    93 IGIAALaiygFHLN-----SVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGTIIGGLA 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  162 F---QFYGINPILI-VSIICFtLSAIMeifihIPhqKTPREVGVIAVAKNDLKDSYTFLK---REKPIFISvIFLVCIFN 234
Cdd:PRK06814   168 TisgNFVILVALLMgIAVLGW-LASLF-----IP--KTGNAAPDLKIDRNIIRSTITLLKyakADKRIWLA-ILGISWFW 238

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 2427153552  235 LVlSAVLIVGLPILISEVLKMPDT-----LYGFSISIII 268
Cdd:PRK06814   239 LV-GAVVLSQLPLLAKETLGGDENvatlfLAVFSVGVAV 276
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 14-183 4.87e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 63.79  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  14 LVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVF 92
Cdd:cd06173   212 LLLLALALFALLGGALTVLLPLLAKEVLGgGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  93 YLSlgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILI 172
Cdd:cd06173   292 GLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367

                         170
                  ....*....|.
gi 2427153552 173 VSIICFTLSAI 183
Cdd:cd06173   368 LAGALLLLAAL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 7-184 6.22e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.36  E-value: 6.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   7 LFNHDFILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVT 85
Cdd:cd17325   196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  86 AIIILVFYLSlgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFY 165
Cdd:cd17325   276 AVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351

                         170
                  ....*....|....*....
gi 2427153552 166 GINPILIVSIICFTLSAIM 184
Cdd:cd17325   352 GFATPFLAAAALLLLAAVL 370
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-188 3.31e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.44  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   7 LFNHDFILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVT 85
Cdd:COG2223   202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGlSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  86 AIIILVFYLSLGRipiIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFY 165
Cdd:COG2223   282 ALGLLLLALALGS---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358

                         170       180
                  ....*....|....*....|....
gi 2427153552 166 G-INPILIVSIICFTLSAIMEIFI 188
Cdd:COG2223   359 GsYTAAFLVFAVLALVALVLTLLL 382
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-267 5.88e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.52  E-value: 5.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  15 VVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYL 94
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  95 SlgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGIN-PILIV 173
Cdd:cd06174    81 A----PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRAVFL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 174 SIICFTLSAIMEIFIHIPHQKTPREVGVIAVAKNDLKDSYTFLKREKPIFIsvIFLVCIFNLVLSAVLIVGLPILISEVL 253
Cdd:cd06174   157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWL--LLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                         250
                  ....*....|....
gi 2427153552 254 KMPDTLYGFSISII 267
Cdd:cd06174   235 GLSVAVAGLLLSLF 248
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 12-188 8.40e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.89  E-value: 8.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSAL-FGIVTACSFLPMVILSLVGGIIADRT---NKRNIMVILDFVTAI 87
Cdd:cd17319   181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKqVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAV 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  88 IILVFYLSLGRIPIIPLFIVALMLLYGISGAYqpavqASIPLLVSSDKLT-VGNAVINQVNTLANFIGPAISGVVFQ-FY 165
Cdd:cd17319   261 GLLLAYLTTSPVVAVILLSLAGFGIGAASPVF-----WSLPADLLPGEAAaTAGGLINSGGNLGGFVAPLLIGYLVDaTG 335

                         170       180
                  ....*....|....*....|...
gi 2427153552 166 GINPILIVSIICFTLSAIMEIFI 188
Cdd:cd17319   336 SYTAAFLFLAAVALLAALLVLLL 358
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 12-272 8.56e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.44  E-value: 8.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVIldfvTAIIILV 91
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI----GLLLFGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYLSLGRIPIIPLFIVALMLLyGISGAY-QPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPI 170
Cdd:COG0477    92 ASLLCGLAPSPELLIAARALQ-GIGAGGlMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 171 LIVSIICFTLSAIMEIFihIPHQKTPREVGVIAVAKNDLKDSYTFLKREKPIFISVIFLVCIFNLVLSAVLIVGLPILIS 250
Cdd:COG0477   171 FLINAPLGLLALVLRLR--LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                         250       260
                  ....*....|....*....|..
gi 2427153552 251 EVLKMPDTLYGFSISIIIRRFM 272
Cdd:COG0477   249 ALLLLLALLLLAALLLLLLLLL 270
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-231 2.68e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.37  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  15 VVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYL 94
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  95 SLGripiIPLFIVALmLLYGIS-GAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIV 173
Cdd:cd17489    81 ATS----VALLLVLR-LIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2427153552 174 SIICFTLSAIMEIFIHIPHQktprevgVIAVAKNDLKDSYTFLKREKPIFISVIFLVC 231
Cdd:cd17489   156 AAVLALLALLLVFLVKDPPP-------VAAEEAEAGTRAFRRLVEKKVLPPALILFLA 206
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 4-184 4.57e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 57.55  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   4 EKKLFNHDFILVVIgqIISLFGNAILRFALPYYLLKETGSSALFGIVT-ACSFLPMVILSLVGGIIADRTNKRNIMVILD 82
Cdd:cd17370   194 SLKKLPKAFWLYLL--AVALFALGNFSFAFLILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  83 FVTAIIILVFYLSLGripiiPLFIVALMLLYGIS-GAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVV 161
Cdd:cd17370   272 LSLALAYLGFALGSS-----LWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL 346

                         170       180
                  ....*....|....*....|...
gi 2427153552 162 FQFYGINPILIVSIICFTLSAIM 184
Cdd:cd17370   347 WDLISPSAAFLFSAVLALIALLL 369
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 12-193 6.10e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 57.18  E-value: 6.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALF-GIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIL 90
Cdd:cd17321   170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQaGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGRIPIIPLFIvaLMLLYGI-SGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFqFYGINP 169
Cdd:cd17321   250 LLALLGADSSVWLLLP--GLVLLGLgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL-TAGLSA 326

                         170       180
                  ....*....|....*....|....
gi 2427153552 170 ILIVSIICFTLSAIMEIFIHIPHQ 193
Cdd:cd17321   327 NLGDSGVAALLSAAAAAFAAGFHL 350
PRK10489 PRK10489
enterobactin transporter EntS;
9-161 2.47e-08

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 55.76  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   9 NHDFILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAI- 87
Cdd:PRK10489   16 HPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLg 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2427153552  88 -IILVFYLSLGRIPIIPLFIVALML-LYGISGAyqPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVV 161
Cdd:PRK10489   96 fIGLALNAFLPEPSLLAIYLLGLWDgFFGSLGV--TALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLL 169
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-268 3.95e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 3.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   1 MQAEKKLFNHDFILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTN-----K 74
Cdd:COG2211     1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  75 RNIMVILDFVTAII-ILVFYL-SLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKL-TVGNAVINQVNTLAN 151
Cdd:COG2211    81 RPWILIGAIPLALSfVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 152 FIGPAISGVVFQFYGINPILIVSIICFTLSAIMEIFIHIPHQKTpREVGVIAVAKNDLKDSYTFLKREKPIFIsvIFLVC 231
Cdd:COG2211   161 LLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGT-KERPVPEEEKVSLKESLKALLKNRPFLL--LLLAY 237

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2427153552 232 IFNLVLSAVLIVGLPILISEVLKMPDTLYGFSISIII 268
Cdd:COG2211   238 LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 21-189 6.87e-08

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 54.04  E-value: 6.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  21 ISLFGNAILrfaLPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFV-TAIIILVFYLslgr 98
Cdd:cd17337   222 LSQFGFPVF---MPLYFTDTGGfSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVgCAISTLLFYY---- 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  99 IPII--PLFIVAL--MLLYGIS-GAYQPaVQASIPLLVSSDKltvGNA--VINQVNTLANFIGPAISGVVFQFYGINPIL 171
Cdd:cd17337   295 VPQLfgHNYWAALiaAILFGIGlAGFVP-LSALMPSLAPEHK---GAAmsILNLGAGLSNFVGPAIVTLFLGSFGAGGVV 370

                         170
                  ....*....|....*...
gi 2427153552 172 IVSIICFTLSAIMEIFIH 189
Cdd:cd17337   371 WIFAGLYLLSAVLTLFLK 388
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-151 7.06e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.82  E-value: 7.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIL 90
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2427153552  91 VFYLSLGripiIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLAN 151
Cdd:COG2814   289 LLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
5-155 4.64e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 4.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   5 KKLFNHDFILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILdFV 84
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA-LL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2427153552  85 TAIIILVFYLSLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGP 155
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
43-266 1.22e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  43 SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYLSlgriPIIPLFIVALMLLYGISGAYQPA 122
Cdd:COG0738    41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA----PSYPLLLLALFLLGLGLGLLDVA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 123 VQASIPLLVSSDK---LTVGNAvinqVNTLANFIGPAISGVVFQFYG----INPILIVSIICFtLSAIMEIFIHIPHQKT 195
Cdd:COG0738   117 ANPYVAALGPETAasrLNLLHA----FFSLGALLGPLLGGLLILLGLslswHLPYLILAVLLL-LLALLFLRSKLPEIEE 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2427153552 196 PREvgviavAKNDLKDSYTFLKREKPIfisVIFLVCIFNLVLSAVLIVG-LPILISEVLKMPDTLYGFSISI 266
Cdd:COG0738   192 EEE------EAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIGDwLPLYLKDVLGLSEATAALGLSL 254
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 31-266 1.45e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 49.85  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  31 FALPY---YLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILdfvTAIIILVFYLSLGRIPIIPLFI 106
Cdd:cd17471    14 FVLPYlslFLTEELGaSPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILL---ALLAGALGYLLFAFLRNYWVLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 107 VALMLLYGISGAYQPAVQASIPLLV---SSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVSIICFTLSAI 183
Cdd:cd17471    91 LVGVVLLSLGAAAFPQLFALAREYAdrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVAL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 184 MEIFIHIPHQKTPREVGVIAVAKNDLKDSYTFLkrekpifisvIFLVCIFNLVLSAVLIVGLPILISEVLKMPDTLYGFS 263
Cdd:cd17471   171 LVLFLLPSVKPPAQKATPASSLVKAPVNRRLLL----------LFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLL 240


                  ...
gi 2427153552 264 ISI 266
Cdd:cd17471   241 FGL 243
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 16-183 1.77e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.48  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  16 VIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYLS 95
Cdd:cd17477   194 LLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  96 lgrIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVSI 175
Cdd:cd17477   274 ---PGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLA 350


                  ....*...
gi 2427153552 176 ICFTLSAI 183
Cdd:cd17477   351 AVALLFLL 358
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-184 3.35e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.71  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYyLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIL 90
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPP-LQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGripiiPLFIVALMLLYGI-SGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGI-N 168
Cdd:COG2271    91 LFGFATS-----FWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWrA 165

                         170
                  ....*....|....*.
gi 2427153552 169 PILIVSIICFTLSAIM 184
Cdd:COG2271   166 AFLILGLPGLLLALLR 181
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 33-183 3.35e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.70  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  33 LPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYLSlgriPIIPLFIVALML 111
Cdd:cd17324   221 LAPFLTDVPGfSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG----PSPLLLLVGLVL 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2427153552 112 LYGISGAYQPAVQASIpLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVSIICFTLSAI 183
Cdd:cd17324   297 WGLGFFAAHSALQTRV-LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-184 5.10e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETGSSALF-GIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIL 90
Cdd:cd06174   205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVaGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLgriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVF-QFYGINP 169
Cdd:cd06174   285 ALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTG 361

                         170
                  ....*....|....*
gi 2427153552 170 ILIVSIICFTLSAIM 184
Cdd:cd06174   362 AFLVLAVLLLLAAIL 376
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 12-176 5.40e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFaLPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILV 91
Cdd:cd17478   198 LLLLIIVFLRSWVLSSLTTF-LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYLSLGrIPIIPLFIVALMLLYgisgayqpavqASIPLLVS------SDKLTVGNAVINQVNTLANFIGPAISGVVFQFY 165
Cdd:cd17478   277 FLLTPG-IWSYILLVLAGFLLF-----------ASFPVTVVlaqellPGNVGLASGLMMGLSFGLGGIGAPVLGALADAF 344

                         170
                  ....*....|.
gi 2427153552 166 GINPILIVSII 176
Cdd:cd17478   345 GLESVLLILAL 355
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 14-183 6.62e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.49  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  14 LVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSL-VGGIIADRTNKRNIMVILDFVTAIiilv 91
Cdd:cd17330   178 RLLLVYFLIALAFAGLESVFSLFLKDRFGfSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAII---- 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  92 FYLSLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPIL 171
Cdd:cd17330   254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333

                         170
                  ....*....|..
gi 2427153552 172 IVSIICFTLSAI 183
Cdd:cd17330   334 LLAAGLLLIALF 345
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 33-184 7.55e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.47  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  33 LPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFylslGRIPIIPLFIVALMLL 112
Cdd:cd17478    19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL----GFAPNYWLLLLLVALA 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2427153552 113 yGI-SGAYQP--AVQASiplLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVSIICFTLSAIM 184
Cdd:cd17478    95 -GIgSAAFHPegARLAS---QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALL 165
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 6-188 2.04e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.34  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   6 KLFNHDFILVV-IGQIISLFGNAILRFALPYYLLKETGSSALFGIVTA-----CSFLPMVILSLVGGIIADRTNKRNIMV 79
Cdd:cd17504   172 RLLRRRNVLLAnITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAgllllPGALVMLIAGPLAGRLIARVGPRRVLL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  80 IldfvTAIIILVFYLSLGRIPIIPLFIVALMLLYGISGAYqpaVQASIPLLVSS----DKLTVGNAVINQVNTLANFIGP 155
Cdd:cd17504   252 I----GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGL---AFASLPNIVVEsvppDRTGIATGMNTVLRTIGSAIGP 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2427153552 156 AISGVVFQFY-------------GINPILIVSIICFTLSAIMEIFI 188
Cdd:cd17504   325 AIAGAILTTYtvsitsggvptegAYVLAFLIGAALALAALLLSLLI 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 4-189 2.43e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   4 EKKLFNHDFILVVIGQIISlfgnAILRFaLPYYLlKETGSS--ALFGIVTACSflpMVILSLVGGIIADRTNKRNIMVIl 81
Cdd:cd17489   193 EKKVLPPALILFLASIAYG----AISTF-LPLYA-AERGISnaGLFFTVYAIA---LLLSRPFSGKLSDRKGPKTVIIP- 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  82 dfvTAIIILVFYLSLGRIPIIPLFIVALmLLYGIS-GAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGV 160
Cdd:cd17489   263 ---GLLLLALGLLLLSFAGSPWMLLLAA-VLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL 338

                         170       180
                  ....*....|....*....|....*....
gi 2427153552 161 VFQFYGINPILIVSIICFTLSAIMEIFIH 189
Cdd:cd17489   339 VAELFGYRAMFLLAAVVVLLALVLYIFLL 367
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-195 2.94e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILdfvtAIIIL 90
Cdd:COG0738   212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLS----ALLAA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGRIPIIPLFIVALMLLY-GISGAYqPAVQASIPLLVSSDKLTVGNAVInQVNTLANFIGPAISGVVFQFYGINP 169
Cdd:COG0738   288 VGLLLALLAPGPWLALIGLALVGlGLSLMF-PTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRA 365

                         170       180
                  ....*....|....*....|....*.
gi 2427153552 170 ILIVSIICFTLSAIMEIFIHIPHQKT 195
Cdd:COG0738   366 AFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 5-184 3.66e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.60  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   5 KKLFNHD--FILVVIGQIISLFGNAILRFALPYYLLK-ETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVIL 81
Cdd:cd17329   193 YKIVLRDraFLLFLLASFLISLIYFQLESTLPVYVVEiLGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  82 dfvtAIIILVFYLSLGRIPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVV 161
Cdd:cd17329   273 ----ILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348

                         170       180
                  ....*....|....*....|....
gi 2427153552 162 FQFYGIN-PILIVSIICFTLSAIM 184
Cdd:cd17329   349 LDLLGPGlPWLILAALGLIAAALL 372
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
33-207 4.53e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.21  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  33 LPYYL--LKETGSSAL---FGIVTACSFLPMVILSLVGGIIADRTNkRNIMVILDFVTAIIILVFylsLGRIPIIPLFIV 107
Cdd:PRK09874   37 LPLYVeqLGVTGHSALnmwSGLVFSITFLFSAIASPFWGGLADRKG-RKIMLLRSALGMGIVMVL---MGLAQNIWQFLI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 108 aLMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPILIVS----IICF--TLS 181
Cdd:PRK09874  113 -LRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITasvlFLCFlvTLF 191

                         170       180
                  ....*....|....*....|....*.
gi 2427153552 182 AIMEIFIHIPHQKTPREVGVIAVAKN 207
Cdd:PRK09874  192 CIRENFQPVSKKEMLHMREVVTSLKN 217
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 9-188 1.58e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.33  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552   9 NHDFILVVIGQIISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAiI 88
Cdd:cd17355   209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA-L 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  89 ILVFYLSLGriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYG-I 167
Cdd:cd17355   288 GLALLLLLP--FPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsY 365

                         170       180
                  ....*....|....*....|.
gi 2427153552 168 NPILIVSIICFTLSAIMEIFI 188
Cdd:cd17355   366 TAAWALAVALGLIAALLVLPI 386
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 12-184 1.62e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  12 FILVVIGQIISLFGNAILRFALPYYLLKETG-SSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIL 90
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  91 VFYLSLGriPIIPLFIVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPI 170
Cdd:cd17316   259 PLFYLLS--GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336

                         170
                  ....*....|....
gi 2427153552 171 LIVSIICFTLSAIM 184
Cdd:cd17316   337 PALILALLAIVALI 350
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 21-179 2.17e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  21 ISLFGNAILRFALPYYL---LKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVIldfvTAIIILVFYLSLG 97
Cdd:cd17330     7 LDALGFGIVFPVLPFYVrefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL----SLAGSAVSYVLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  98 RIPIIPLFIVAlMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGI-NPILIVSII 176
Cdd:cd17330    83 LSRNLWLLFLA-RFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYaLPFLVAAAL 161


                  ...
gi 2427153552 177 CFT 179
Cdd:cd17330   162 ALL 164
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 48-187 3.79e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.17  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  48 GIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIIlvfyLSLGRIPIIPLFiVALMLLYGISGAYQPAVQASI 127
Cdd:cd17391    39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI----GLMAFVTNVWQL-LILRLLQGVFSGYVPNATALI 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2427153552 128 PLLVSSDKLTVGNAVINQVNTLANFIGPAISGVVFQFYGINPI-LIVSIICFtLSAIMEIF 187
Cdd:cd17391   114 ASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVfFITGGLLF-LAFLLTLF 173
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 21-266 4.90e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 4.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552  21 ISLFGNAILRFALPYYLLKETGSSALFGIVTACSFLPMVILSLVGGIIADRTNKRNIMVILDFVTAIIILVFYLSlgriP 100
Cdd:cd17474    10 LAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS----D 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 101 IIPLFiVALMLLYGISGAYQPAVQASIPLLVSSDKLTVGNAVINQ-VNTLANFIGPAISGVVFQFYGINPILIVSIICFT 179
Cdd:cd17474    86 SFALL-LAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEaALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2427153552 180 LSAIMEIFIHIPHQKTPRevgviavaKNDLKDSYTFLKREKPIFISVIFLVCIFNLVLSAVLiVGLPILISEVLKMPDTL 259
Cdd:cd17474   165 AFLAILFLLPEPKEKAKS--------SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFL-TYLPFLLELLYGISPII 235


                  ....*..
gi 2427153552 260 YGFSISI 266
Cdd:cd17474   236 IGLLFAG 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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