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Conserved domains on  [gi|2443546377|ref|WP_273181031|]
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putative quinol monooxygenase [Methylophaga aminisulfidivorans]

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 8.38e-12

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 56.11  E-value: 8.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443546377  2 IHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSVEAHmMTFRESAGFEAWRSLAGP 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAAL-EAHLASPHFKAFLAALAP 79

                         90
                 ....*....|.
gi 2443546377 82 FFAAPPKVYHL 92
Cdd:COG1359   80 LLAEPPEVRVY 90
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 8.38e-12

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 56.11  E-value: 8.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443546377  2 IHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSVEAHmMTFRESAGFEAWRSLAGP 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAAL-EAHLASPHFKAFLAALAP 79

                         90
                 ....*....|.
gi 2443546377 82 FFAAPPKVYHL 92
Cdd:COG1359   80 LLAEPPEVRVY 90
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-76 3.63e-09

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 48.81  E-value: 3.63e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2443546377  2 IHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSvEAHMMTFRESAGFEAWR 76
Cdd:pfam03992  1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWED-EAAFEAHLQSPHFKAAH 74
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 8.38e-12

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 56.11  E-value: 8.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443546377  2 IHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSVEAHmMTFRESAGFEAWRSLAGP 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAAL-EAHLASPHFKAFLAALAP 79

                         90
                 ....*....|.
gi 2443546377 82 FFAAPPKVYHL 92
Cdd:COG1359   80 LLAEPPEVRVY 90
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-97 2.13e-11

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 55.00  E-value: 2.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443546377  1 MIHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSVEAHmMTFRESAGFEAWRSLAG 80
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAF-RAWFRSSEHRAAHAKGR 79

                         90
                 ....*....|....*....
gi 2443546377 81 PFFAAPPKV--YHLALAVA 97
Cdd:COG2329   80 EILAGPPRVehYEVVAEVE 98
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-76 3.63e-09

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 48.81  E-value: 3.63e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2443546377  2 IHEVAELTVTPQDMRAFEQAVKEAAPHFQAADGCHGMRLEKVIEQPGQYRLIVAWDSvEAHMMTFRESAGFEAWR 76
Cdd:pfam03992  1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWED-EAAFEAHLQSPHFKAAH 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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